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UT Health San Antonio launches clinical trial to study rapamycin and healthy aging - UT Health San Antonio

Contact: Eileen Teves, 210-450-7239, tevese@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, March 25, 2026 – UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is launching a multi-phase clinical study to better understand how the drug rapamycin may promote healthy aging. Funded by the National […]

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Mar 25 • 1:05 PM EDT • Health • news.uthscsa.edu
I’m still fighting for honest health care transparency

Opinions from across America, powered by the Washington Post

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Mar 25 • 12:02 PM EDT • Health • washingtonpost.com
New studies of old dogs help scientists understand where they came from

Using the oldest dog genes studied so far, scientists are finding more evidence that our furry friends have been our companions for thousands of years. Scientists think dogs descended from an ancient...

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Mar 25 • 12:00 PM EDT • Science • yahoo.com
Supreme Court tosses $1B copyright verdict in record companies' battle over illegal internet downloads

The Supreme Court unanimously ruled Wednesday that internet providers are not liable for copyright infringement by their users, delivering an opinion in Cox v. Sony and tossing a $1 billion verdict.

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Mar 25 • 10:28 AM EDT • Business • foxbusiness.com
Service & Solidarity Spotlight: Kaiser Health Care Professionals Ratify New Contracts, Winning Vital Patient Safety Protections

Health care professionals, members of United Nurses Associations of California/Union of Health Care Professionals (UNAC/UHCP, AFSCME), voted to ratify new contracts with Kaiser Permanente, winning critical protections that will directly improve patient care.

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Mar 25 • 10:02 AM EDT • Health • aflcio.org
Opinion | When faith becomes a weapon in Alabama politics

Wes Allen’s attack on John Wahl reveals a dangerous tactic—using faith as a political weapon rather than a guiding principle.

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Mar 25 • 9:34 AM EDT • Politics • alreporter.com
I didn’t pay attention to politics. Then my house fell down

This Overland Park independent voter is reminded of his father’s advice, and applies it to our democracy. | Opinion

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Mar 25 • 9:01 AM EDT • Politics • kansascity.com
When is work on the RenCen going to start?

In this video, Crain’s Detroit Business senior reporter Kirk Pinho outlines the steps needed for the project to become a reality.

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Mar 25 • 5:45 AM EDT • Business • crainsdetroit.com
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SW FL Business Hall of Fame honors four new leaders. Read about them

Junior Achievement of Southwest Florida inducted four new laureates into its Business Hall of Fame on March 24.

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Mar 25 • 5:01 AM EDT • Business • news-press.com
SW FL Business Hall of Fame honors four new leaders. Read about them

Junior Achievement of Southwest Florida inducted four new laureates into its Business Hall of Fame on March 24.

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Mar 25 • 5:01 AM EDT • Business • naplesnews.com
The labor leader behind California’s billionaire tax showdown

For decades, Dave Regan has used California’s direct democracy system in a relentless campaign to shore up union power — and his own. But his newest mission is on an entirely different scale.

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Mar 25 • 5:00 AM EDT • Politics • politico.com
UMass Chan junior faculty receive child health research grants from Hood Foundation

Silvia Galván Peña, PhD, and Jin Zhang, PhD, are two of five recipients of a 2026 Hood Foundation Award.

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Mar 25 • 12:13 AM EDT • Health • umassmed.edu
Why your brain may be sabotaging your balance as you age

Balance problems in aging and Parkinson’s may come from the body working too hard, not too little. Scientists found that the brain and muscles become overactive during even minor disturbances, yet this actually weakens balance recovery. At the same time, muscles can stiffen against each other, making movement less stable. This unexpected pattern could help predict who is more likely to fall.

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Mar 24 • 8:00 PM EDT • Science • sciencedaily.com
Victor Wembanyama, surging Spurs face depleted Grizzlies

The San Antonio Spurs are building momentum as the season winds down, a push that is putting pressure on Western Conference leader Oklahoma City.

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Mar 24 • 7:20 PM EDT • Sports • cbssports.com
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Opinion | Is the Madness of Sports Betting Here to Stay?

Students discuss the expansion of online gambling across the U.S.

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Mar 24 • 6:07 PM EDT • Sports • wsj.com
Democrats’ long-shot bid to flip Alaska’s Senate seat

Democrats are hoping for an upset in Alaska’s Senate race. U.S. Rep. Mary Peltola, a Democrat, is trying to unseat Republican incumbent Sen. Dan Sullivan. We discuss the major issues at play, plus why Republicans are backing an effort to repeal Alaska’s ranked-choice voting system.This episode: voting correspondent Miles Parks, senior political editor and correspondent Domenico Montanaro, and Alaska Public Media Washington correspondent Liz Ruskin.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye.Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.

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Mar 24 • 4:49 PM EDT • Politics • npr.org
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UT Health San Antonio Multispecialty and Research Hospital treats first clinical trial participant in novel cancer study - UT Health San Antonio

Milestone paves the way for advancements in cancer care, innovation and patient care in San Antonio and South Texas. UT Health San Antonio Multispecialty and Research Hospital has enrolled and treated its first clinical trial participant in a novel cancer study, marking a pivotal moment for science and patient-centered cancer care in San Antonio and […]

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Mar 24 • 1:40 PM EDT • Health • news.uthscsa.edu
Georgia: Opposition politician Elene Khoshtaria given politically motivated prison sentence for graffiti

In Elene Khoshtaria’s case, the severity of the punishment appears related not to material damage, but to her political opinions and the symbolic damage she has inflicted on the ruling party

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Mar 24 • 1:16 PM EDT • Politics • amnesty.org
Why Philadelphia’s workplace protections for menstruation and menopause are necessary

Opinions from across America, powered by the Washington Post

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Mar 24 • 12:34 PM EDT • Health • washingtonpost.com
City of San Antonio asks for feedback on renaming César E. Chávez Boulevard

You can take the survey on the city’s website.

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Mar 24 • 12:06 PM EDT • Politics • spectrumlocalnews.com
Opinion | Climate Science Is Creeping Into Courtrooms

Judges are fed biased information from progressive activists and a flawed scientific reference manual.

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Mar 24 • 10:55 AM EDT • Science • wsj.com
Kaus Earns College Sports Communicators Academic All-District Honors

ITHACA, N.Y. – Cornell women's basketball junior Rachel Kaus has been named to the College Sports Communicators (CSC) Academic All-District team, the organization announced on Tuesday.

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Mar 24 • 9:10 AM EDT • Sports • cornellbigred.com
Personnel note: Natalie Brown departs RSA, heads back to Senate as Danny Burgess Senior Aide

'During her time with us, she added significant value to our clients and brought a level of direction and strategy to our Session approach and appropriations process.'

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Mar 24 • 9:02 AM EDT • Politics • floridapolitics.com
Helping seniors thrive through connection

ETSU is one of three universities nationwide selected to develop senior nutrition programs.

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Mar 24 • 8:00 AM EDT • Health • news.etsu.edu
San Antonio 2026 Teen Mental Health Survey now open

Teenagers can share their experience with mental health in an ongoing survey meant to inform city policy.

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Mar 24 • 7:29 AM EDT • Health • axios.com
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Opinion | Nothing against California-based Sutter Health, but Allina’s local governance matters

Allina is built on a "model of care that puts patients and families at the center of everything. That is not something that transfers automatically with a transaction. It has to be protected deliberately, by people who understand what it is and why it matters," the writer says.

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Mar 24 • 5:59 AM EDT • Health • startribune.com
Opinion | Why Are So Many Democrats So Far Out of Touch?

Candidates in safe districts are under no pressure to moderate in order to win.

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Mar 24 • 5:02 AM EDT • Politics • nytimes.com
Modernizing Pinnacol is about its members, not politics

By Akasha Absher While we share the passion for protecting Colorado’s workers expressed in a recent op-ed from the perspective of trial attorneys and union representatives, the piece paints a picture of Pinnacol Assurance that is more rooted in 1915 than our 21st-century reality (“Colorado’s workers can’t afford a privatized Pinnacol | OPINION,” March 17). […]

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Mar 24 • 2:45 AM EDT • Politics • coloradopolitics.com
We disagreed on politics. We agreed on wine. That was enough.

At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.

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Mar 23 • 10:54 PM EDT • Politics • dmwineline.substack.com
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Miami starts cutting property tax rebate checks for seniors

'This program is about delivering real relief where it matters most.'

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Mar 23 • 6:43 PM EDT • Politics • floridapolitics.com
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Dual-threat Dixon makes an impact beyond his own sport

Few athletes embody their sport and community like senior track and field athlete Ashriel Dixon.

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Mar 23 • 5:49 PM EDT • Sports • dailynebraskan.com
Opinion | We Can’t Let Crypto and A.I. Buy the Policies They Want

We can’t let crypto and A.I. buy the policies they want.

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Mar 23 • 3:45 PM EDT • Politics • nytimes.com
Senior Playgrounds Are the Latest Healthy Aging Trend With Real Benefits

They're full of low-impact equipment for seniors to get their bodies moving and keep their minds active.

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Mar 23 • 1:49 PM EDT • Health • today.com
Business Insider welcomes Ryan Kailath

Ryan Kailath joins Business Insider as a Senior Editor on the Economy team.

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Mar 23 • 12:22 PM EDT • Business • businessinsider.com
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Nominate a Capital Region health care executive who’s making a difference

Who’s running the organizations shaping health care in the Capital Region — and doing it well? That’s the question at the heart of the Outstanding Health Care Executive category in Business Report‘s inaugural Excellence in Health Care Awards. This recognition is for the senior leaders who are making the hard calls, building strong teams and […]

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Mar 23 • 10:27 AM EDT • Health • businessreport.com
A Look At PENN Entertainment (PENN) Valuation As Expansion Projects And New Financing Move Ahead

Expansion plans and fresh financing reshape the PENN Entertainment story PENN Entertainment (PENN) has put expansion and balance sheet moves front and center, with new casino and hotel projects in Aurora and Columbus alongside a fresh US$600 million senior notes offering. See our latest analysis for PENN Entertainment. Despite the new projects and financing, PENN’s 1 year total shareholder return of 21.21% and 5 year total shareholder return of 86.08% sit well behind peers. A recent 4.99% 1...

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Mar 23 • 6:07 AM EDT • Entertainment • simplywall.st
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Spurs vs. Heat odds, prediction, time: 2026 NBA picks for Monday, March 23 from proven model

SportsLine's proven model has revealed its San Antonio Spurs vs. Miami Heat predictions and NBA picks today

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Mar 23 • 6:01 AM EDT • Sports • cbssports.com
Opinion | Doctors should be paid to keep patients healthy

Value-based care works best when physicians lead, specialists share accountability, and long-term outcomes matter.

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Mar 23 • 3:00 AM EDT • Health • bostonglobe.com
Scholar Athlete of the Week: Andra Stokes, Stevens High School

KSAT 12 Sports and CHRISTUS Children’s shine a spotlight on a local senior student athlete

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Mar 22 • 11:49 PM EDT • Sports • ksat.com
Simona Martin: Colorado’s data center boom needs public health guardrails

As AI infrastructure expands across the state, lawmakers face a choice about who bears the costs and risks.

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Mar 22 • 11:00 PM EDT • Health • boulderreportinglab.org
A DNA test ruled him out. He was convicted of murder anyway.

Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.

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Mar 22 • 9:57 PM EDT • Science • bostonglobe.com
Scientists Identified a Speech Trait That Foreshadows Cognitive Decline

A hidden signal.

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Mar 22 • 7:21 PM EDT • Science • sciencealert.com
Politics, protests and popular culture: The University of Minnesota community responds to ICE impact through memes and music

Outside Coffman Union on March 3, The University of Minnesota’s Students for a Democratic Society protested Immigration and Customs Enforcement’s presence in Minnesota and on campus, despite reports that Operation...

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Mar 22 • 6:52 PM EDT • Politics • mndaily.com
Opinion | Jesse Jackson, the Prophet Who Became a Politician

He challenged black Americans in the 1960s and ’70s, then retreated into victimhood and grievance.

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Mar 22 • 4:52 PM EDT • Politics • wsj.com
Nasal swab may catch Alzheimer's disease earlier — here's how it works
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Mar 22 • 3:48 PM EDT • Health • nypost.com
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Federal union says 'untrained' ICE agents shouldn't replace TSA

President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.

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Mar 22 • 3:12 PM EDT • Business • businessinsider.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Immigration crackdown impact on local Latino-owned businesses

Latino business owners told WRAL News that fear and uncertainty following a nationwide crackdown in immigration enforcement are keeping some families out of public spaces, leaving small businesses struggling to survive. This story was written by Oriana Torre, a senior graduating journalism student at the University of Florida, participating in the CBC-UNC News Media Multiplatform Fellowship.

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Mar 22 • 1:39 PM EDT • Business • wral.com
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Cuba Says Its Military Is Prepared as Trump’s Threats Multiply

A senior Cuban official said the country is preparing for a possible military assault as President Donald Trump increases economic pressure on the government in Havana and suggests it could be the next US target after Venezuela and Iran.

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Mar 22 • 9:00 AM EDT • Politics • bloomberg.com
Colorado lawmakers can pass “Alyssa’s Act” to help coaches and parents monitor mental health (Opinion)

In 2019, we lost Alyssa after she struggled with her mental health following a series of concussions. We later learned that concussions can be linked to serious mental health challenges and an increase in suicide, especially in young people.

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Mar 22 • 7:01 AM EDT • Health • denverpost.com
Opinion | Are Ed Markey and other politicians hooked on power?

Can neuroscience explain why politicians like Bill Galvin won’t quit?

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Mar 22 • 4:00 AM EDT • Politics • bostonglobe.com
OU women's gymnastics senior Faith Torrez scores perfect 10, while Sooners lose in SEC championship

No. 1 OU women’s gymnastics (18-1-1) finished second in the Southeastern Conference Championship against No. 3 Florida (15-2-0), No. 2 LSU (12-5-1) and No. 4 Alabama (9-8-0) Saturday, with the

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Mar 21 • 11:42 PM EDT • Sports • oudaily.com
Four-star forward Joe Philon commits to UCLA

Joe Philon, a four-star power forward in the 2026 class, has committed to UCLA, he told On3. The 6-foot-8 senior out of Montverde Academy (FL) chose the Bruins after considering Ohio State, South Florida, UNLV, and Xavier. Philon, a native of Tampa, Florida, is the No. 56 overall player in the 2026 class, according to […]

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Mar 21 • 6:54 PM EDT • Sports • sports.yahoo.com
UFC London live blog: Movsar Evloev vs. Lerone Murphy

Follow along for live updates on Movsar Evloev vs. Lerone Murphy at UFC London

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Mar 21 • 6:33 PM EDT • Sports • sports.yahoo.com
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47th annual Utica University science fair shows area students are smarter than ever

Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.

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Mar 21 • 5:00 PM EDT • Science • romesentinel.com
Young scientists shine at Regional Science Olympiad

Budding young scientists from throughout the region participated in the 41st Annual Stanislaus County Regional Science Olympiad on March 14 at Modesto Junior College.

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Mar 21 • 2:20 PM EDT • Science • turlockjournal.com
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Musicians’ union hosts free health clinic in Treme

Local chapter of American Federation of Musicians offers free screenings to working entertainers

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Mar 21 • 1:26 PM EDT • Health • fox8live.com
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Farmers and rural community members can access free mental health resources

KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.

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Mar 21 • 12:14 PM EDT • Health • cbs2iowa.com
Hannah Hidalgo's historic season hits March Madness. What to know about Notre Dame star

Notre Dame star Hannah Hidalgo set several program, ACC and NCAA records this season. Here's what to know about the junior guard in March Madness.

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Mar 21 • 12:03 PM EDT • Sports • usatoday.com
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Tee-time thaw

Remnants of winter linger as golfers tee off during opening day at Candia Woods Golf Links in Candia on Friday which also was the first day of spring.

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Mar 21 • 10:35 AM EDT • Sports • unionleader.com
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California settles with El Monte schools over misconduct complaints

The El Monte Union High School District must appoint a compliance coordinator and roll out an electronic sexual misconduct complaint system.

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Mar 21 • 9:59 AM EDT • Business • businessinsider.com
Billionaires, trial lawyers and unions gear up for 2026 California ballot brawls

It costs millions to qualify for the ballot and most measures fail, but that’s not stopping lots of special interest groups from trying

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Mar 21 • 8:00 AM EDT • Politics • sacbee.com
Letters to Sports: WBC brings joy back to All-Star-level play

Readers of the Los Angeles Times Sports section give their thoughts and opinions on the World Baseball Classic, Shohei Ohtani and the Lakers.

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Mar 21 • 7:00 AM EDT • Sports • latimes.com
Kaiser Health Care unions ratify new contracts

LOS ANGELES, Cali. (KESQ) — After months of negations, including multiple strikes, UNAC/UHCP health care professionals have voted to ratify new contracts with Kaiser Permanente. During this negotiation period, union members walked off the job in January in what became the longest open-ended strike by nurses and health care professionals in U.S. history, lasting nearly

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Mar 21 • 12:10 AM EDT • Health • kesq.com
Spurs look to extend winning streak while hosting hapless Pacers

The San Antonio Spurs carry a four-game winning streak as they continue their hunt for the top spot in the Western Conference while hosting the hapless Indiana Pacers on Saturday.

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Mar 20 • 11:46 PM EDT • Sports • cbssports.com
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Exclusive | Growing Frustration With Chuck Schumer Spurs Talk of Replacing Him

Some Democrats on Capitol Hill are discussing how to get New York’s senior senator to step aside as minority leader amid concerns about his negotiating style and midterms strategy.

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Mar 20 • 9:00 PM EDT • Politics • wsj.com
Opinion | Why the Trump FCC Cares About Your Sports Viewing

Its irrepressible chairman never runs out of ways to advance the president’s political interests.

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Mar 20 • 4:57 PM EDT • Sports • wsj.com
Whitman School Announces Alumnus, Business Leader as 2026 Convocation Speaker

Steven W. Barnes ’82, H’19, a senior advisor at Bain Capital and former Board of Trustees chair, will address graduates at the May 9 ceremony.

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Mar 20 • 4:30 PM EDT • Business • news.syr.edu
Giants Ace Logan Webb on Negative Team USA Narrative: 'It's B---S---'

San Francisco Giants ace Logan Webb made his opinion on the negative narrative surrounding Team USA clear: "It's b---s---."

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Mar 20 • 3:15 PM EDT • Sports • foxsports.com
35 photos that show what life looked like in 1973

A senior portrait so perfectly 1973 it could have been Michael Kelso's yearbook photo — the side-swept hair, the wide lapels, the expression of a guy who knows exactly how good-looking he is. The menu behind him says coffee is 15 cents.

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Mar 20 • 1:04 PM EDT • Technology • aol.com
US House Democrat blasts Commerce's 'highly concerning' $1.6 billion USA Rare Earth deal

A senior House Democrat accused U.S. Commerce Secretary Howard Lutnick on Thursday of structuring Washington's $1.58 billion investment into USA Rare Earth ​in a way that gives the government "highly concerning" leverage over the company while boosting Lutnick's family-run investment firm.

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Mar 20 • 12:30 PM EDT • Business • reuters.com
Opinion | There’s No Judicial Climate Science Scandal

My co-writer and I didn’t commit academic misconduct in our chapter for a federal evidence manual.

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Mar 20 • 11:42 AM EDT • Science • wsj.com
Watch live: Whole Hog Politics with Chris Stirewalt and Bill Sammon

The Hill’s senior vice president of editorial content, Bill Sammon, joins NewsNation’s Chris Stirewalt to discuss the latest political hot topics and national news in Whole Hog Politics. The show w…

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Mar 20 • 8:17 AM EDT • Politics • thehill.com
Trump aides tried to block appointment of Peter Mandelson as UK ambassador to US, reports say

Senior figures said to have been skeptical over Keir Starmer’s appointment of ‘arrogant’ veteran politician, later sacked over connections to Jeffrey Epstein

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Mar 20 • 7:14 AM EDT • Politics • theguardian.com
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Linda Flanagan: Sports Aren’t for All Girls

There’s nothing wrong with preferring dance or music over track and field.

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Mar 20 • 6:15 AM EDT • Sports • wsj.com
The Problem With Promoting ‘Gold Standard Science’

Opinion | Branding scientific research with a simplified label risks misleading the public and harming scientific literacy.

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Mar 20 • 5:00 AM EDT • Science • undark.org
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Dothan senior breaks 75-year barrier with international science fair qualification

Alexis Saffold earned her spot in the Regeneron International Science and Engineering Fair by turning an everyday problem into a potential breakthrough.

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Mar 19 • 8:38 PM EDT • Science • wtvy.com
New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

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Mar 19 • 5:28 PM EDT • Technology • gamefile.news
Study Reveals a Turning Point When Your Body's Aging Accelerates

Brace yourself.

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Mar 19 • 5:26 PM EDT • Science • sciencealert.com
Packers coach Matt LaFleur finalizes his staff moves for 2026

Green Bay's new quarterbacks coach is Luke Getsy, a former Las Vegas Raiders and Chicago Bears offensive coordinator who spent last season as a Packers senior assistant. Getsy previously was Green Bay's quarterbacks coach from 2019-21. The Packers also hired Scott Fuchs as a defensive analyst, T.C. McCartney as offensive quality control coach and Will Smart as a defensive quality control coach.

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Mar 19 • 3:49 PM EDT • Sports • sports.yahoo.com
Senior-laden Purdue pivots to ‘March mode’ vs. newbie Queens

For the third time in four years, Purdue enters the NCAA Tournament with a top two seed and a lot of experience.

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Mar 19 • 3:02 PM EDT • Sports • cbssports.com
Humans and animals have the same preference in mating calls, citizen science experiment finds

The bright colors of butterfly wings, the sweet aromas of flowers, and the euphonious melodies of songbirds all evolved as signals that help individuals propagate, yet humans also find these very same ...

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Mar 19 • 2:00 PM EDT • Science • phys.org
'Dark oxygen' discovery on the seafloor is 'fundamentally at odds with thermodynamics' and should be retracted, experts say

In a recent opinion article, marine scientists and electrochemists listed a number of reasons why it's unlikely that metallic nodules on the deep seafloor could produce oxygen in total darkness.

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Mar 19 • 12:24 PM EDT • Science • livescience.com
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International Arctic delegation gets crash course on Fairbanks politics

More than 20 dignitaries are visiting the Fairbanks North Star Borough this week as part of an European Union-sponsored initiative to foster collaboration among Arctic nations.

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Mar 19 • 10:00 AM EDT • Politics • newsminer.com
Allina Health acquisition by California's Sutter raises union concerns over contracts, pensions
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Mar 19 • 8:42 AM EDT • Health • cbsnews.com
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Opinion: The dirty politics behind Judge Torgerson’s censure

Doug McMurdo: If Utah lawmakers were really worried about “the children,” where was their outrage when Stuart Adams ushered in a change to Utah’s statutory sexual assault law to protect a relative? It’s hypocrisy, plain and simple.

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Mar 19 • 8:00 AM EDT • Politics • sltrib.com
Afternoon Update: Why is the NIH abandoning science? (opinion)

Plus, a conversation with the Harvard historian Annette Gordon-Reed.

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Mar 19 • 8:00 AM EDT • Science • chronicle.com
Labor unions' influence in LA mayor's race is harder to predict this year

As Mayor Karen Bass vies to keep her seat, she has a liberal opponent and a more complicated relationship with some labor leaders.

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Mar 19 • 8:00 AM EDT • Politics • calmatters.org
Khan says Labour should rejoin EU customs union and single market this parliament

London mayor also says his party should make clear manifesto commitment on full membership in next parliament

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Mar 19 • 4:57 AM EDT • Politics • theguardian.com
Forum on harnessing Artificial Intelligence for health equity

Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org

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