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BYU-Idaho Launches BYUI Live! as New Name for Campus Entertainment
From chart-topping bands and Broadway stars to comedians and inspirational performers, live entertainment has become a valued part of the BYU-Idaho experience. Brigham Young University-Idaho is pleased to announce the rebranding of its long-running Center Stage series as BYUI Live!—a new name that reflects the university's vision to create memorable live entertainment experiences that bring BYU-Idaho students and the surrounding community together.
Hormel Foods Announces Agreement to Sell Ceratti Business in Brazil
/PRNewswire/ -- Hormel Foods Corporation (NYSE: HRL), a Fortune 500 global branded food company, today announced it has entered into a definitive agreement to...
French election politics bring surrogacy back into Europe’s spotlight
The former prime minister's call to legalize surrogacy has drawn opposition from across France's political spectrum, including within his own party, with possible consequences across Europe.
Dayton Business Journal: Former Ohio State, Arizona State administrator named Wright State athletic director
Following the university’s first-ever national search for a Division I athletics director, Wright State University has selected a new leader for its athletic program. Wright State has named Brad Chandler as the next director of athletics. “I am incredibly grateful … Continue reading →
NBA vet Malik Beasley, former player Ed Davis indicted on illegal sports gambling charges
Beasley is a former first-round draft pick and nine-year NBA veteran. Davis played for eight teams, ending in 2021-22.
Former NFL star Chris Johnson makes heartbreaking health announcement
The NFL is filled with gridiron legends who sacrifice their bodies every Sunday in pursuit of a Super Bowl championship. But even the game’s greatest stars aren’t invincible. On Monday, former Tennessee Titans running back Chris Johnson revealed that he…
Titans Legend Chris Johnson Reveals Heartbreaking ALS Diagnosis
Former Tennessee Titans star and NFL great Chris Johnson shared his diagnosis publicly for the first time, hoping his story will inspire awareness, research, and hope for others battling ALS.
Former Titans running back Chris Johnson announces ALS diagnosis
Former Tennessee Titans running back Chris Johnson announced he has been diagnosed with amyotrophic lateral sclerosis, or ALS.
Former Titans star Chris Johnson reveals ALS diagnosis: 'I chose to fight'
Chris Johnson is one of nine players to rush for over 2,000 yards in a single season.
Q4 Earnings Highs And Lows: EchoStar (NASDAQ:ECHO) Vs The Rest Of The Media & Entertainment Stocks
As the Q4 earnings season wraps, let’s dig into this quarter’s best and worst performers in the media & entertainment industry, including EchoStar (NASDAQ:EC...
Trafalgar Entertainment acquires Nicholas Hytner’s Bridge theatre
London Theatre Company founded in 2017 by Hytner and former National Theatre colleague Nick Starr has been sold to company that owns 20-plus venues in UK and abroad
FAIR Health Price-Informed Tools Support Healthcare Decisions Among Diverse Older Adults
/PRNewswire/ -- Price-informed shared decision-making tools developed by FAIR Health, a national, independent nonprofit, can facilitate meaningful healthcare...
Lauryn Hill honored, Janet Jackson stuns and Druski makes history at BET Awards
Hill performed “Ex-Factor” Sunday
Her next act: Former House speaker announces 'Nancy Pelosi Institute'
Pelosi’s involvement in the NPI is not just in namesake: in the new year, she will co-teach a course on Congress with Professor Eric Schickler
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges
Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges
Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy.
Nancy Pelosi to establish new democracy institute at UC-Berkeley
The former House speaker is preparing to leave Congress after a nearly four-decade decorated career.
Building Business: New hotel taking shape on Portland's Monument Square
Zachau Construction is transforming the former Fidelity Trust building into a 101-room luxury hotel, for Jim Brady’s Fathom Cos.
Add Lynn Bartels to Colorado’s roll call of legends
A few weeks after the Rocky Mountain News shut its doors forever in 2009, more than 600 Republicans gathered for the state party’s annual Centennial Dinner. Lamenting the historic significance of the loss of one of Colorado’s great daily newspapers, the state chairman noted the presence that evening of former Rocky political reporter Lynn Bartels […]
Former ‘Meet the Press’ Executive Producer Betsy Fischer Martin to Lead Harvard IOP | News
Former ‘Meet the Press’ Executive Producer Betsy Fischer Martin to Lead Harvard IOP | News | The Harvard Crimson
After 40 years in Congress, Nancy Pelosi to help create institute to train leaders of the future
The former House speaker plans to help create an institute at UC Berkeley that will concentrate on civic engagement and research
Framingham Baking Co. workers 'couldn't let it go.' What they did next
Two former Framingham Baking Company kitchen workers have started their own baking business.
Notable Rutgers grads and former students
Some notable Rutgers alumni include James Gandolfini, Chris Christie, Eric LaGrand and more.
Ex-boss Foyle returns to Port Vale as chief scout
Former Port Vale player and manager Martin Foyle returns to the League Two club as its chief scout.
Jose Mourinho eyes Chelsea mainstay as his ‘priority’ signing
Former Real Madrid manager Xabi Alonso has taken over the reins as Chelsea’s new coach and is already planning the squad and his dynamics for the upcoming season.The revolutionary thinker that he is...
Former Mets coach Eric Chavez slams David Stearns in rant
Former New York Mets hitting coach and bench coach Eric Chavez offered a brutal takedown of David Stearns, the team’s president of baseball operations, in an episode of “The EC3 Pod” on June 28. Stearns has come under heavy criticism…
Conservative presidential power expert set to assist investigation into Trump foes
John Yoo — a well-known and, in some legal and political circles, infamous conservative lawyer — will assist a Justice Department investigation that has theorized a yearslong conspiracy against President Donald Trump and is looking at several former high-ranking federal officials.
Van crashes into former Benson business
A minivan drove through the side of a vacant building in Benson early Sunday morning, according to police.
'Nobody likes you': Argument between former teammates Josh Naylor and Austin Hedges gets personal in Mariners-Guardians
Trump news at a glance: Biden says Trump has ‘diminished’ US standing in the world as he attacks his successor
Former president calls Trump ‘a loser’ and criticizes his attempted makeover of Washington. Key US politics stories from Sunday 28 June at a glance
Former WJZ reporter, weekend sports anchor Stan Saunders dies at 72
Former WJZ reporter and weekend sports anchor Stan Saunders died on Friday, June 26, his family said. He was 72 years old.
Baker Mayfield Drops Clear Message on Kyler Murray
As Kyler Murray seeks a fresh start in Minnesota, former teammate Baker Mayfield defends the polarizing quarterback, predicting a dominant resurgence fueled by a much-needed change of scenery.
Jamie Foxx, Daughter Anelise's Duet During Kehlani's 2026 BET Awards Performance Will Warm Your Heart
Jamie Foxx and daughter Anelise Bishop, 17, played piano and guitar while Kehlani performed "Folded" at the 2026 BET Awards June 28 at Los Angeles' Peacock Theater.
Andy Burnham’s meteoric rise tells us much about how politics and power are changing
The former may of Greater Manchester’s rise raises questions about the changing dynamics of political parties and leadership in an accelerated political climate.
Stetson Bennett dealing with ‘business side’ of NFL in QB competition with Rams
Former Georgia quarterback Jake Fromm provides perspective on the challenge Stetson Bennett faces competing with Ty Simpson on the Los Angeles Rams.
Former Gov. Larry Hogan talks state of politics in Maryland
Tom Fitzgerald sits down with former Maryland Governor Larry Hogan to discuss the state of politics in Maryland and The Hogan Institute at Washington College.
Bills decline to honor O.J. Simpson in making the move to new stadium
Simpson died two years ago, and his reputation became forever stained by charges that he killed his former wife and her male friend in 1994.
Former local star B.J. Daniels advocates for mental health awareness
Former Lincoln and NFL standout B.J. Daniels turns personal struggles into a message of hope for athletes everywhere.
Bond girl Eva Green is 'recovering' after suffering an injury on 'Wednesday' set
Former Bond girl Eva Green is recovering after suffering an injury on the set of 'Wednesday' season 3, which will see her portray Aunt Ophelia Frump.
England will miss Stokes' winning persona
Former England captain Michael Vaughan reflects on Ben Stokes' shock retirement and how the team can move on from one of their "greatest" players.
EXCLUSIVE: Three Candidates Vying For Global Fund Leadership In Contentious Race
As the Global Fund heads into a secretive but highly contentious election of its new Executive Director, the names of three likely US candidates have surfaced - former Global Fund Executive Director Mark Dybul, former Trump appointee William Steiger and a former NYC public health official, Ashwin Vasan.
Inside California Politics: Former LA city councilmember weighs in on mayoral race
(Inside California Politics) — With Los Angeles Mayor Karen Bass now set for a tough reelection campaign against former ally turned rival Nithya Raman, a former member of the L.A. City Council spok…
Former McCarthy aide details Trump’s expletive-laden attacks on lawmakers and the wild fight to put McCarthy in office
Google employee who made nearly $1 million explains why he left
A former Google employee says AI equity, job security concerns, and years of side projects convinced him to leave and build his own company.
Inside country legend Alan Jackson\'s triumphant finale concert
Country music legend Alan Jackson has ended his touring career. On Saturday night, he performed his final show at Nashville's Nissan Stadium. The event, titled “Last Call: One More for
Two years after their last debate, Biden jabs at Trump: ‘What a loser’
As he rallied Maryland Democrats at a state party fundraiser Saturday night, former President Joe Biden decried the actions of the man who succeeded him in the White House, painting him as vain and corrupt.
Walker Buehler Admits He ‘Especially’ Wants to Beat Dodgers
The Dodgers lost the series opener to the Padres, a game with a ton of storylines, including Walker Buehler facing his former team.
The Orlando Magic Waive Defensive Versatile Forward Jonathan Isaac
The Orlando Magic severs ties with the former lottery pick to avoid a looming salary guarantee, ending an injury-plagued nine-year tenure while seeking financial flexibility for a critical offseason.
Trump says he is nominating former Oklahoma state trooper Lance Schroyer as ICE director
Schroyer's nomination comes after former ICE director Todd Lyons resigned at the end of May. David Venturella, a former executive at a private prison operator, has been serving as the acting head of the agency.
Trump says he’ll nominate former Oklahoma state trooper as ICE director
President Donald Trump announced Saturday that he will nominate Lance Schroyer, a former Oklahoma state trooper and Marine, to be the next director of Immigration and Customs Enforcement.
Oxford bring in former Hearts defender Kent
League One side Oxford United sign former Hearts defender Frankie Kent on a free transfer.
Former NFL star Warrick Dunn hosts wellness day with health screenings, financial education
Saturday’s event was centered around improving physical health, financial stability, and mental well-being.
'She likes that he's outside of the entertainment world': Reese Witherspoon happy that new boyfriend is not an actor
Reese Witherspoon loves that her boyfriend is not in the entertainment industry. The Legally Blonde actress – who was previously married to her Cruel Intentions co-star Ryan Phillippe and former CAA t...
Andy Burnham distanced himself from UK Prime Minister Starmer, but may be stuck with his policies
Burnham, the former mayor of Greater Manchester who was sworn into Parliament hours after Starmer announced his resignation on Monday, will be constrained by the platform the center-left Labour Party was elected on that decisively ended 14 years of Conservative rule in 2024.
Former Eagles WR A.J. Brown Predicted to Threaten NFL Record
NFL.com's Bucky Brooks predicts former Eagles WR A.J. Brown could break the 2,000-yard receiving mark with the Patriots in 2026. The post Former Eagles WR A.J. Brown Predicted to Threaten NFL Record appeared first on HEAVY.
Former Washington health care executive pleads guilty to $24 million wire fraud scheme
A former health care executive in North Central Washington has pleaded guilty to wire fraud after prosecutors say he siphoned tens of millions of dollars.
Best investments over the past 100 years? Almost all are tech companies
Most of the top performers are tech companies, headed by Apple, Nvidia and Microsoft.
Former Saints WR Joe Horn inducted into the Louisiana Sports Hall of Fame
Horn spent 7 seasons with the New Orleans Saints
Which coach helped Dianna Russini get out of a ticket?
The recent New York Times article regarding former New York Times reporter Dianna Russini answered some lingering questions.
Week in Politics: Trump and bipartisan housing bill, John Bolton; Democratic socialists
President Trump canceled a signing for major housing legislation, former National Security Advisor John Bolton pled guilty to mishandling classified documents, and Democratic Socialists made gains.
Former Giannis Role Players Now On Milwaukee Bucks Trading Block
The Milwaukee Bucks are turning the page to a new chapter in their franchise following the trade of Giannis Antetokounmpo to the Milwaukee Bucks. Along with opening a new era, the Bucks are also looking to move on from some of their role players during the team’s Giannis phase. Among them are Kyle Kuzma and […] The post Former Giannis Role Players Now On Milwaukee Bucks Trading Block appeared first on HEAVY.
Why 6 Google employees left one of tech's most coveted employers
Six former Google employees explain why they left one of tech's most coveted employers.
Why 6 Google employees left one of tech's most coveted employers
Six former Google employees explain why they left one of tech's most coveted employers.
Walker Buehler delivers statement win for the Padres over Dodgers
The Sporting Tribune's Fernando Ramirez writes about Walker Buehler throwing a solid game against his former team.
Steelers add former Cowboys part-time starter to defensive staff
The Steelers added former Cowboys safety turned coach Darian Thompson to their staff reuniting him with head coach Mike McCarthy
Good Sports: Former Bulldog track and field athlete aims to be flag football Olympian
Last June, Kaja Bins didn't know what flag football was. Kaja now has the potential to become an Olympian in a sport she learned a year ago.
‘A total fairytale’: Former Watergate prosecutor reacts to Vance’s comments on the scandal
Burkina Faso cuts diplomatic ties with former colonial ruler France
The military government, in power since 2022 coup, accused France of having 'neo-colonial ambitions'.
A World Cup watch party reconnected me with someone from my past
Jill Tucker taught English in Cape Verde 35 years ago, and was surprised when one of her former students recognized her at a World Cup watch party.
Health system CEO fired without cause in wake of class-action lawsuit over unnecessary surgeries
Reese Jackson, the former president and CEO of Chesapeake Regional Healthcare was unceremoniously dismissed from his role on June 1. Jackson has been named as a defendant in a pending class-action lawsuit filed by 900 women.
Pete Buttigieg was briefly separated from his children after police say he was target of false report
Former Transportation Secretary Pete Buttigieg was the target of an anonymous report that police determined was false and that he says forced him to spend a night away from his four-year-old twins.
Old Lord and Taylor building transforms into food and entertainment destination in Midtown
The former Lord and Taylor building has reopened and now offers restaurants, bars and curated eateries.
Roy Cooper brings 'Make Stuff Cost Less' tour to Asheville, targets health costs, tariffs
Former North Carolina Governor and U.S. Senate candidate Roy Cooper brought his "Make Stuff Cost Less" tour to Asheville on Friday.
See inside Kemba Walker's new youth sports hub
The former Charlotte Hornets star says the academy is about creating opportunities for the next generation of athletes.
HOMETOWN ENTERTAINMENT Standup comedian Susan Horne offers preview of upcoming show in Lynchburg
Comedian Susan Horne among the featured performers at upcoming evening of clean comedy in Lynchburg.
Civility advocates look for ways to restore 'Iowa Nice' to campaigns, public discourse
A group of former and current officeholders are looking to encourage civility by encouraging civic participation and civil interactions.
Ex-national security adviser John Bolton pleads guilty to illegally retaining classified information
Former Trump administration national security adviser John Bolton pleaded guilty on Friday to illegally retaining classified information, sealing a deal with federal prosecutors that could allow him to avoid a prison term.
Kylie Jenner's former chef alleges 'intense' workload led to miscarriage
Kylie Jenner has been hit with a third workplace lawsuit as her former chef claims the job's "intense" demands led to a pregnancy loss.
Inside the courtroom where Trump’s former adviser-turned-critic John Bolton just pleaded guilty
Trump Administration Shut Down Climate Website, Former NOAA Employees Have Just Brought It Back
In June 2025, Climate.gov was shut down by an executive order that implied it did not meet the current administration's standards. Climate scientists have just brought the data back.
Climbing gym planned in former Summerlin-area movie theater
The gym, which will fill the old Regal Theater on 9400 W. Sahara Ave. in Summerlin, is set to open later this year or early next.
How PENN’s US$360 Million Aurora Resort Shift At PENN Entertainment (PENN) Has Changed Its Investment Story
PENN Entertainment has opened the US$360 million Hollywood Casino and Hotel Aurora, replacing its former Fox River riverboat with a 388,500-square-foot, 24/7 land-based resort featuring over 1,000 slots, 50 table games, a sportsbook, 226-room hotel, spa, event center, and extensive dining options. The Aurora project, which created around 700 permanent roles and mirrors PENN’s broader shift into higher-amenity land-based properties, highlights how the company is reinvesting heavily to refresh...
ConcernedApe Explains Why He's Shown So Little Of Haunted Chocolatier: 'I Would Rather Serve A Fully Baked Bread'
Eric Barone posted his first blog update in six months yesterday to reassure fans he's still hard at work.
Scientists stunned by signs of ancient life in a place no one expected
Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.
Starlink veterans launch startup to broaden megaconstellation ownership
Former SpaceX engineers who helped build and scale Starlink have launched a startup aiming to deliver megaconstellations for governments and companies seeking more control over space-based infrastructure.
Former Illinois forward Ben Humrichous signs contract with Nets
Heading to Brooklyn.
Kenny Klein, former longtime Louisville Athletics administrator, dies
Kenny Klein, a former Louisville Athletics administrator of 39 years who worked more than 1,300 straight men's basketball games, has died at age 65.
Trump nominates Chris Klomp as HHS second-in-command
President Donald Trump on Thursday named Medicare director and former health care executive Chris Klomp to be deputy secretary of the US Department of Health and Human Services.
Ex-NFL player Doug Martin's family sue Oakland police, allege restraint asphyxia in fatal mental health crisis
Parents of former NFL running back Doug Martin file wrongful death lawsuit alleging he died from restraint asphyxia caused by Oakland police.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Former Steeler says drafting Pat Freiermuth was a mistake
The criticism was voiced on an episode of Cam Heyward’s
Kurt Zellers out in shakeup at Minnesota Business Partnership
The lobbying group replaced with co-interim CEOs, a former state director for Amy Klobuchar and a Republican aide.
That's 'Entertainment!': Q and A with Jon King of Gang of Four
Gang of Four stormed out of Leeds, England in 1976, rewiring punk rock with a Molotov cocktail of jagged guitar, danceable rhythms, and intellectual political critique. The group remains one
Dating Coach Urges All Men to Avoid 'Worst' Hobby for Single Guys
A professional dating coach isn't holding back on the "F" tier hobby for single men in the United States. Blaine Anderson, a former travel industry worker who built a successful dating coach business,...
Kurt Zellers Steps Down as CEO of the MN Business Partnership
The former legislator’s tenure in this key role lasted less than three years.
Platner, Collins’ campaign spar over federal contracts
Platner released a multi-point plan he calls “a corruption crackdown,” which covers issues such as big money in politics, lobbying activities by former members of Congress, and making it more difficult for presidents to cash in on their position while in office.
Lionel Richie takes ill, cuts opening concert of tour short
The Rock & Roll Hall of Famer, who is 77, told his 10,000 fans he was feeling dizzy but performed for nearly an hour before leaving the stage.
Databricks’ former AI chief thinks he can cut AI’s power bill by 1,000x
Un0 is an image-generation system tool that shows for the first time how the company's technology can replicate conventional AI systems.