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Denzel Boston a non-factor against Titans
Denzel Boston turns in his second dud in a row in Week 7
Tibetan river hosting world’s biggest dam is facing increasing flood risk: study
Researchers create a hydrological history using tree rings and data to project future run-off and flood risk in the Yarlung Tsangpo River.
World-First Cancer Vaccine Cuts Melanoma Recurrence or Death Risk by 42% in Landmark Trial
"This has not been achieved before in the history of cancer drug development."
Illustration shows "Cyberattack" text and PHP code
The word "Cyberattack" and PHP code are displayed on a screen in this illustration taken on October 22, 2026.
Can the Public Sector Offset Road-Construction Losses?
Hennepin Avenue was a cautionary tale.
Why Young Sheldon’s Emily Osment Asked for Intimacy Coordinator to Film With Co-star Montana Jordan
‘Plans to die in office': Bay Area congressman's ex-aides protest challenger's ads
Seven former staffers of Rep. Mike Thompson demand that challenger Eric Jones' campaign remove a commercial targeting the North Bay legislator.
Il Volo celebrates nearly 20 years of musical harmony
Longer than many marriages and most rock bands, the Italian singing trio Il Volo have been together for almost 20 years. They’ve gone from teenagers to 30-somethings while selling more
Trump critic Lula wins reelection in Brazil, securing fourth presidential term
Brazil’s President Luiz Inácio Lula da Silva, a vocal critic of President Donald Trump, has been reelected in a result that provides relief to critics of widening U.S. influence in
Vandalia Health recognized for digital health achievement
Vandalia Health earned Level 9 recognition in both acute and ambulatory care in the 2026 Digital Health Most Wired Survey.
Corpus Christi Museum of Science and History turns Halloween into a hands-on learning experience for kids
The Corpus Christi Museum of Science and History made Halloween educational with hands-on activities, experts and a Mad Science Show.
IN GOOD HEALTH: Preparing for respiratory illness season
By Leanna Coy, FNP-BC As temperatures begin to cool and the holiday season gets underway with Halloween this month, it’s time to prepare for fall and winter respiratory illnesses. As we…
Lions QB Jared Goff Ties NFL History Against Rival Packers
The Detroit Lions are back in action on Sunday afternoon at Ford Field against the divisional rival Green Bay Packers in a clash that will carry heavy implications for the NFC North standings. And thanks to yet another strong start from quarterback Jared Goff, he’s not only put his club in a position to pick […] The post Lions QB Jared Goff Ties NFL History Against Rival Packers appeared first on HEAVY.
APTOPIX Brazil Election
Supporters of President Luiz Inacio Lula da Silva celebrate after he won the presidential runoff in Rio de Janeiro, Sunday, Oct. 25, 2026. (AP Photo/Lucas Landau)
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing
Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo
The World Health Organization reports that a nurse has been killed and a health worker severely injured in an attack while responding to an Ebola alert in Congo. This attack,
Attackers kill nurse, severely injure health worker responding to Ebola case in eastern Congo
BUTEMBO, Congo (AP) — A nurse was killed and a health worker severely injured after being attacked while responding to an Ebola alert in Congo, according to the World Health
Gauging Global Access to Dermatology Care: Q&A With Esther E. Freeman, MD
Dermatologist and epidemiologist Esther E. Freeman discusses the Global Access to Skin Health Observatory Study and how its findings will hopefully help improve dermatology care worldwide.
Young Scientists Congress: New technologies take centerstage at science exhibition in Wenzhou
The World Young Scientists Congress has opened in Wenzhou, east China's Zhejiang Province. More than 800 scientists and entrepreneurs from over 60 countries and regions are attending the event which includes an exhibition of the latest technologies. We spoke with some of the visitors to the event.
2026 KlarText Prize for Science Communication: Klaus Tschira Foundation Honors Seven Researchers
What exactly did you do in your doctoral dissertation? The Klaus Tschira Foundation honors the most compelling answers to this question with the KlarText Prize for Science Communication. On Octobe ...
"Tomb Raider: Legacy of Atlantis" 30th Anniversary Trailer
A new trailer is out for “Tomb Raider: Legacy of Atlantis,” the reimagining of the original 1996 first “Tomb Raider” game. Created in Unreal Engine 5, it offers fresh visuals, skill trees, and an expanded Atlantis story that will tie in the various eras of Lara Croft together. As Lara, harness your wits and athleticism […]
Why OU's win over Mississippi State sparks cautious optimism
OU took down Mississippi State on the road with a dominant offensive performance on Saturday.
Trump invokes anti-Muslim rhetoric to attack El-Sayed at Port Huron rally
President Donald Trump has been telling crowds of supporters at rallies across the nation that they should vote in November as if he is on the ballot — a theme he invoked again in Michigan this weekend.
Thousands protest in Prague against public media funding reforms
Demonstrators allege Prime Minister Andrej Babis and his coalition's proposed reforms pose a threat to press freedom.
Elon Musk’s Grok Imagine Releases First Odyssey Episode With Wonder Studios
8 sources compared: Other (4), Western Mainstream (3), Latin American (1). Elon Musk’s Grok Imagine released the first episode of its AI-generated series “The Odyssey,” posting a seven-minute vid...
Vucic Concedes Electoral Defeat, Setting Stage For New Era Of Serbian Politics, Relations With West
Aleksandar Vucic, Serbia's former president and dominant political figure for more than a decade, conceded defeat to the student-led protest movement in the country's parliamentary elections, potentially ushering in a new era of politics more closely aligned with Europe and away from the Kremlin.
Kyle Larson’s Championship Moment Comes at Talladega
Conquering his drafting-track demons, Larson surged from mid-pack chaos to secure a historic Hendrick 1-2 finish, building a massive points cushion that places the title within reach
“Odegaard was outstanding” but Merson was less complimentary about Gyökeres
Paul Merson has delivered contrasting verdicts on two Arsenal players following Saturday’s comfortable 2-0 victory over Everton, singling out Martin Ødegaard for praise while questioning Viktor Gy�...
Iowa family finds strength beyond the gym after cancer diagnosis
URBANDALE, Iowa (KCCI) -- Azariah Townsend can barely reach the pull-up bar in his family’s home gym in Urbandale, but he already knows strength is not measured by height.
Open Thread: Colorado Avalanche @ Nashville Predators (6:00 P.M. MDT)
Tonight is another Colorado Avalanche game day as they pay a visit to Nashville to face the Predators!
Sports equinox 2026: Date, schedule, meaning and history behind the rare event
The 33rd sports equinox will occur in 2026.
Early voting underway in Michigan
Early voting began Saturday, Oct. 24 in Michigan. County officials say the first day of early voting went well and more than half of mail-in ballots have already been returned.
Dunwoody to discuss adding two entertainment districts
The Dunwoody City Council will discuss adding two new entertainment districts – Georgetown and Jett Ferry – at its meeting on Monday, Oct. 26.
Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega
Kyle Larson took a thrilling win in a wild last-lap rally that led to a photo-finish with William Byron, his Hendrick Motorsports teammate. Larson, who was eighth heading down the backstretch of the final lap, had everything go his way ahead of him, as he sliced and diced his way back to the front. Ricky […] The post Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega appeared first on TobyChristie.com.
With flu season off to an unusually early start, here's what doctors are seeing
It's not even Halloween yet, but doctors say flu season off to an unusually early start.
Eye on Northwest Politics: Oct 25, 2026 (Christine Drazan)
Reporting Portland and Vancouver area breaking news and weather stories to make Oregon and Southwest Washington a better place to live
Eye on Northwest Politics: Oct 25, 2026 (Tina Kotek)
Reporting Portland and Vancouver area breaking news and weather stories to make Oregon and Southwest Washington a better place to live
TMSM Weekly Recap: Star Wars Super Bowl, Cap Lifts Thor's Hammer, Halloweentown 5 and More
Missed anything? Here are the biggest Disney stories from October 18 to 24, from Star Wars Funday Football and Avengers: Doomsday to Halloweentown 5 and Gideon's new trading cards.
ATM stolen from business in Brighton Park, Chicago police say
Chicago police are looking for the people who stole an ATM from a convenience store Sunday morning on the city's Southwest Side.
Absent Vinícius Jr. ‘laughs’ at Barcelona after Real Madrid victory
Real Madrid star Vinícius Jr. has on Sunday evening taken to social media, to issue his response to his side’s victory over arch rivals Barcelona.José Mourinho’s troops made the trip to the Spo...
Raptors to miss Kawhi Leonard on Sunday night
The Raptors will be without a key piece of their lineup on Sunday night.
Democrat Coumba Kebe wants to keep the politics out of the treasurer’s office
Political newcomer Coumba Kebe is the Democratic nominee for Indiana state treasurer. Kebe wants to keep the politics out of the office and build back trust with people.
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race
The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.
Lawmakers propose $11M fix to restore school sports and activities funding
by Katie Klingsporn, WyoFile Wyoming’s new school funding model added more than $250 million in state education funding, including for widely supported
Bengals Shut out in Disastrous First Half vs Ravens
The Cincinnati Bengals are off to a first half they’d like to forget. Cincy trails the Baltimore Ravens 13-0 in Baltimore.The story has been the Cincinnati Bengals’ defense which has been struggling against this Ravens offense.The Ravens got off to a hot start as Zay Flowers took a 48-yard pass to the house from backup […] The post Bengals Shut out in Disastrous First Half vs Ravens appeared first on HEAVY.
Novant Health hosting Hilton Head hiring event Oct. 28
Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.
Jalen Coker not a big factor in Week 7
Panthers WR Jalen Coker caught only one of four targets in Week 7 and posted only nine yards
Health West Chubbuck expands hours, adds X-ray services and two new providers
CHUBBUCK — Health West has announced that it has expanded the services offered at Health West Chubbuck and that it has added two new providers to its staff as well
How Republican anti-Muslim politics gets built into US cities
Republican anti-Muslim rhetoric can turn religious prejudice into zoning barriers, making equal treatment for all citizens a test of democracy
British Columbia's new premier lucks into the job in unexpected political turn
An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.
BC's new premier lucked into the job in an unexpected political turn
An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.
Vučić concedes defeat in Serbian elections, says student movement won
The election was seen as a referendum on Vučić’s political dominance and the political system that has been in place in Serbia for more than a decade.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Here's how Bengals' second half vs Ravens made NFL history
The Cincinnati Bengals became just the 10th team in NFL history to get shut out in the first half and then score 35 points or more in the second half.
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam
Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.
Historic Texas theater sold to New York wellness business
Not everyone is happy about this development.
Why Democrats see a path to victory in Mississippi midterm election
Cleveland Browns rookie WR hits historic mark against Titans
KC Concepcion’s 129 receiving yards places him in the Top 10 for a single game by a rookie in franchise history.
Frisco Muslims vote in Texas midterms marked by anti-Islam rhetoric
Texas politicians have campaigned on banning Shariah this cycle. Muslim voters are encouraging their fellow believers to get involved in politics.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Utah business, government leaders deepen connections in Ireland
Utah Gov. Spencer Cox met with Irish Prime Minister Micheál Martin on Wednesday amid a trade mission organized by World Trade Center Utah.
Science 4 Everyone: How does sod and tall fescue work?
Science teacher and Storm Team4 Meteorologist Ryan Miller explains how to use sod in your yard to prepare for cooler weather.
Why is the U.S. accusing Canada of election interference?
the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.
Editorial: Company mergers are causing more harm to the entertainment industry than good
Two weeks ago, Paramount officially completed its $110 billion purchase of the historic Warner Bros.
‘Masterplan’: Too lightweight to make an impact
Pretty faces can’t overcome ho-hum plotting
TCU to offer lifestyle medicine certification for doctor of occupational therapy students
Lifestyle medicine focuses on helping patients change their lifestyles in order to prevent, treat and reverse chronic disease.
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Halloween evolved as a Frankenstein of cultural celebrations
The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.
The Future of IBD Treatment: 4 Promising Therapies to Know About
New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.
Nintendo reveals why you don't actually fight Bowser in Super Mario Bros. 1
Nintendo’s Shigeru Miyamoto has shared some insight into why players don’t actually fight Bowser in the original Super Mario Bros. Miyamoto was present at a press conference at the end of the week to celebrate him becoming the first developer to win Japan’s Order of Culture award. During the event, he was asked to share behind-the-scenes stories about the making...
Binaytara Implementation Science Research Awards 2027 - Oncology News, Insights, Stories by OncoDaily
The Binaytara Implementation Science Research Awards 2027 provide up to $25,000 per project to support early-career investigators improving how evidence-based
Blanche defends DOJ lawsuit blocking Alaska Senate results if Republican loses
Attorney General Todd Blanche defended the Justice Department's suit over Alaska's Senate race in an interview on CNN.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame
Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.
BCM hosting special Nov. 13 show for America 250
BRISTOL — In partnership with The Crooked Road: Virginia’s Heritage Music Trail, Mountain Empire Children’s Choral Academy, and Theatre Bristol, the Birthplace of Country Music Museum is bringing together an
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record
'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.
Union County Best of the Best Business of the Year Magnolia Renovations Joshua Andrews, owner
What was your reaction when you learned your business had been named Business of the Year?
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Clatsop County health inspections for September
Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]
Argentina Folk Sounds, Controversy: Milo J, Cazzu, Broke Carey
Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside and sharing their history with the world.
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride
Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois
Saturday's loss marked the third straight game in which Oregon scored under 20 points.
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race
WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Attorney General Todd Blanche is defending the Trump administration’s lawsuit to block certification of Alaska's Senate results if incumbent Republican Dan Sullivan loses the race.
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex
West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.
Epic CEO Tim Sweeney lambasts “abhorrent” Steam AI Disclosure Policy claiming labels double as “political statement”
Epic Games CEO Tim Sweeney called Steam’s AI disclosure policy abhorrent, arguing that it exposes developers to backlash from anti-AI detractors. Valve has implemented and updated the policy since 2024, which states that AI-generated content, including artwork, text, music, and assets, excluding assistant tools, requires formal disclosure.
11 Cool Mini-Gadgets You May Not Realize Exist
You probably weren’t looking for a remote-control paper plane or a $600 calculator. Fair enough. They exist anyway, and they’re weirdly hard to ignore.
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department
BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun
A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily
Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.
Obama and Trump wage one last battle for even more urgent stakes
Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.
Cost of employer-sponsored health insurance rises again, survey finds
WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.