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Scranton woman charged with stealing funds from federal health care programs
A Scranton woman stole checks, some of which came from federal health insurance programs, and used them on herself, federal authorities say
Mayor Mamdani, NYC Health + Hospitals break ground on $255M River Commons, bringing 328 affordable affordable homes to the South Bronx
The city has broken ground on River Commons, a mixed-use development in Morrisania that will bring 328 affordable and supportive apartments, an expanded
July 2 Vallejo/Vacaville Arts-Entertainment Source: Activities
July 2: Benicia Farmers Market, 4 p.m., Downtown Benicia at First Street. July 2: Bunco Night, Vacaville Museum Guild, 5 p.m., 213 Buck Ave. To purchase tickets online, access Vacavillemuseum.org/events/. July 2: GVRD Bite Nite: 5…
Supreme Court strikes down Watergate-era limits on campaign funds for political parties
The Supreme Court ruled again that campaign funding is free speech protected by the 1st Amendment.
Contract extension marks 'fresh start' for Taylor
Midfielder Fraser Taylor is relishing a "fresh start" under new St Mirren boss Craig McLeish after signing a two-year contract extension. The 23-year-old academy graduate, whose deal now runs to summer 2028, made his first-team debut in 2022 and featured 13 times for the Buddies last season before joining Partick Thistle on loan in January. "I'm really pleased, since the new manager has come in, he spoke to me on the off-season, and his ideas really suit the way I like to play," said Taylor.
Supreme Court rejects Trump's plan to limit birthright citizenship
The justices said Trump may not revise the Constitution and change citizenship laws in an executive order.
Live Updates: Supreme Court Rules on Banning Transgender Athletes From Women’s Sports
The court’s decision involving laws from West Virginia and Idaho has implications for 25 other states with similar restrictions. Times reporters are reading it and providing analysis.
Win Fin, Flow Fork, Speed Sniffer: Specialized launches 'fastest road bike ever made' in the S-Works Tarmac SL9
American brand draws on Formula 1 lap times software to quantify performance beyond just aero and weight
What Seattle World Cup matches mean for Chinatown International District
Local organizers ensured they made no promises to business owners, despite some estimates Seattle would see 700,000 visitors.
Round table: Manufacturing Revoultion
••• SPONSORED SECTION ••• Manufacturing historically has conjured a certain perception, one of low skills, low pay and low advancement. But times are changing, and they’re changing fast. Spurred by North Carolina’s often lauded economic environment, manufacturers from a variety of sectors are advancing, investing and expanding across the state. But those moves come with […]
Nutrition apps can help build healthy habits. For some users, their gaming features carry risks
The next time you get a trophy on a smartphone app, it might not be from a game.
Contributor: Mental health care isn't ready for psychedelic side effects
Accelerated FDA approval will invite recklessness. But don't block these important medications. Take steps to prepare.
Sequins! Dancing queens! ABBA! Backstage for 'Mamma Mia!’
Twenty-five years after its Broadway debut, the veteran BTS creatives of “Mamma Mia!” helps turn the Ahmanson Theatre into an ABBA-fueled, multigenerational dance party.
Two are elected to the USC wing of the L.A. Times Sports Hall of Fame
Two people have been elected into the USC wing of our Los Angeles Times Sports Report Hall of Fame .
AI cuts hospital system's MRI wait times by more than 50%
The health network, which operates 37 hospitals in California, drastically reduced scheduling delays after integrating an FDA-cleared algorithm designed to speed up imaging acquisition times.
DEA Comes Out Swinging in Cannabis Rescheduling Hearing
The government argued in support of currently accepted medical use; anti-rescheduling parties attempted to poke holes in the Schedule III recommendation.
How the Supreme Court became a power that is reshaping America
Sometimes, these days, it feels like the Supreme Court is running the country.
NYT Crossword Answers for June 30, 2026
John Liber makes his New York Times Crossword debut.
What to stream: ‘Enola Holmes 3,’ Madonna’s new album and ‘Zorro’
"Enola Holmes 3" and a new album from Madonna are some of the new television, films, music and games headed to a device near you.
Netflix and Superheroes Are Having a Rough Stretch on Streaming....
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) I have a quick prediction before we start today’s article: You might see this data in future news articles. Not my specific charts or analysis, but the core trend I’ve been monitoring—Netflix is having a lackluster Q2—will become inescapable. Often, folks want to know “What does the data say?” Well, that’s what it says. I haven’t seen this analysis hit the trades really yet, but I have a feeling some other outlets are going to start making this case soon. Remember, you read it here first. You probably have read about the problems facing superhero films at the box office this weekend. Well, this week, I explore whether superheroes are dying on TV as well! And the data says: definitely maybe! We have a lot to cover in today’s Streaming Ratings Report, which covers the two weeks of 18-May and 25-May. Today, I’m just looking at TV, like Netflix’s disappointing Q2, superhero shows underwhelming, a few TV shows dropping off the charts, The Pitt finally ending its epic run on the viewership charts (and whether “view counts” change its status as one of the biggest shows of all time), all the flops, bombs and misses, and a whole lot more. Tomorrow, I’ve got a great rundown of the film side of things. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, Showlabs, TV Time trend data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of May 18th to May 31st, 2026. You can find a link to my terminology here.) Subscribe Television - Netflix’s Q2 Slump Continues Having analyzed streaming ratings for going on half a decade, I have learned to trust my gut, but I’m always relieved when I can find actual data to back it up. For example, after a string of very popular shows like Stranger Things, Bridgerton, The Lincoln Lawyer and The Night Agent came out, week after week, in January and February, my gut wondered if Netflix had enough new and returning TV shows to sustain them throughout the year. Since then, Netflix’s post-March slate of shows has not impressed me. This week seemed to feature a potential new hit, but then, like a classic Duffer Bros. TV show, there was a twist. I speak of The Boroughs, Netflix’s latest (and last) Duffer Bros. produced show. The pitch is “Stranger Things with older actors”. And it topped the Nielsen charts: With just two weeks of viewership, The Boroughs would have been a top 25 debut show last year: But here’s the twist: Netflix has already cancelled The Boroughs! What happened? Likely a few things. First, the show didn’t do as well globally as it did in the US. As What’s on Netflix showed, it lagged behind several other shows that got cancelled. Second, its completion rate was likely low; after an initial burst of interest, it quickly dropped off on the Samba TV and Luminate charts. Third, the Duffer Bros. left Netflix for Paramount, and that may have factored into Netflix’s decision here. (Though I tend to believe that if a show is doing well, Netflix would have kept greenlighting seasons.) Still, just because I can explain why Netflix may have cancelled this show doesn’t mean I’m justifying it. In particular, as I’ve noted before, Netflix is losing a lot of their bigger shows as they reach their natural ends, and they need to replace those shows. This show had the hallmarks of a big new genre show, and it’s their biggest hit of the last few months (in the US at least), but now it’s done. Netflix’s other show this week—The Four Seasons, the second season of the “hit” show from last year—definitely disappointed. Its sophomore season had about half the viewership of the first, only 12.7 million hours. It also only had a two week run on Samba TV, and its numbers were all down on Luminate too. In other words, even with two successes, the Q2 slump for Netflix looks real: I could add to the list of disappointments: Both Lord of the Files and Man on Fire had short runs on the Nielsen charts. Running Point’s sophomore season also opened to about half its viewership, similar to The Four Seasons. A Good Girl’s Guide to Murder’s second season—see below—didn’t even make any of the three viewership charts I track, unlike the first season. Netflix is absolutely having a dismal second three months of 2026. If this Nielsen data is any indication, and I think it is, I think this will show up in Netflix’s engagement report, and maybe even their financial outcomes. And the rest of June doesn’t look much better. We have two hit shows coming back—Sweet Magnolias, one of their quietest big shows, and Avatar: The Last Airbender, a big hit for them in 2024—but the other big swings are limited series crime thrillers i.e. no future season potential. Like I said above, sometimes when I uncover a juicy nugget like this, other outlets end up writing very similar articles mimicking the data without credit. We’ll see if that happens this time! Share Television - The State of Superhero Shows on Streaming When I first heard the pitch for Spider-Noir—a Sony TV show on Prime Video that binge-released eight episodes first on MGM+ then on Prime Video two days later—I had my doubts. It’s a live-action Spider-Man show set in the 1930s, starring Nicholas Cage, based on a cameo of a character in Spider-Man: Into the Spider-Verse. No, seriously, that’s the pitch. That could either go terrifically well or horribly wrong. Great because, Spider-Man. He’s the biggest superhero we have. I’ve seen tracking numbers that put the new _Spider-Man: Brand New Da_y as the blockbuster of the year and initial pre-sales back that up. And yet this Spider-Noir pitch feels very esoteric. (Also, the eight-episode binge release feels very “Amazon copying Netflix” again.) So what’s the data say? And what does this say about the future of superhero shows?
This Gainesville restaurant failed its health inspection with a 68. Here’s why
A Gainesville nuevo latino restaurant received a failing grade on its health inspection.
Moira Macdonald recommends movies to watch in July
There are plenty of options to escape the heat at local indie moviehouses, including an impressive assortment of free movies.
AI is rewriting the political competitive landscape
Artificial intelligence is rapidly becoming a central infrastructure layer in political campaigns, reshaping how elections are financed, contested and influenced, The New York Times reports. Campaigns and affiliated political groups are increasingly investing in AI-driven tools for voter targeting, message optimization and large-scale content generation, turning modern elections into capital-intensive, technology-enabled competition. This shift is […]
New estimate: Earth has 14 to 20 million insect species
For 40 years, we thought Earth was home to six million insect species. Turns out, it could be three times that.
Preaching the Gospel—not politics—at America’s 250th anniversary
As we approach the 250th anniversary of the founding of the United States, preachers face a sacred responsibility—to proclaim the Gospel and heed the signs of the times, without getting lost in political ideologies.
Thomas, Gorsuch target landmark ruling Trump says protects the 'fake news'
Clarence Thomas and Neil Gorsuch call for overruling New York Times v. Sullivan in their dissent over the CNN-Dershowitz defamation decision.
Arkansas basketball coach John Calipari to be inducted into Memphis Sports Hall of Fame
Calipari reached the NCAA Tournament six times with Memphis, including a national runner-up finish in 2008, and won the 2002 NIT title.
Supreme Court: Trump may fire heads of independent agencies, but not the Federal Reserve
The court's conservatives said the president had the authority to remove all officials who wield executive authority, even if the agency officials had fixed terms set by law.
Supreme Court won't revive Alan Dershowitz's $300 million suit against CNN
Dershowitz had urged the court to reconsider New York Times Co. v. Sullivan. The landmark First Amendment case that made it harder for public figures to win libel lawsuits because it requires proof that an outlet knowingly published something false, or showed a reckless disregard for the truth.
To reduce wait times, UVM Health is demanding its docs see more patients
A recent report commissioned by a state-appointed overseer largely blames long wait times on low productivity among the network’s doctors, and argues wait times also contribute to unnecessarily high prices.
Heat forces yodelers at annual Swiss festival to sing in fountains
Yodelers at a festival in Basel, Switzerland, turned city fountains into rehearsal spaces during Europe’s June heat wave.
Usernames Are Coming to WhatsApp Soon. Here's How to Reserve Yours
Even if you only use WhatsApp sometimes, you might want to snag your username now to stop giving out your phone number.
Apple Acquires Award-Winning App 'Play'
In February, Apple notified the European Commission that it would be acquiring certain assets from and have the right to hire certain employees from Rabbit 3 Times, the company behind the award-winning app design tool Play. The notification was published on the European Commission's website this week, following a four-month waiting period. Play was a Mac and iPhone app that allowed designers to prototype iPhone app interfaces using Apple's SwiftUI frameworks, and then send them to Xcode.
Comcast is spinning off NBCUniversal media and entertainment assets
Comcast is spinning off its NBCUniversal entertainment and media assets into a separate publicly traded company.
How Lenders Evaluate Small Business Loans
Jeanette Mack from Navy Federal Credit Union is here to help you understand what lenders are looking at when considering your small business loan application.
A $1000 PlayStation 6 No Longer Sounds Crazy, As Sony Doesn’t Intend To Sell Hardware At Significant Losses
The PlayStation 6 is set to launch at one of the most challenging times for consumer tech, if not the most challenging. With the rising prices of components, RAM and SSDs above all, manufacturers are having an extremely hard time keeping costs down, and with a bill of materials that is now close to $1000, there's a very high chance the system will cost way more than most anticipated. Adding fuel to the fires of speculation is Sony itself, as the company heavily suggested in a recent investor Q&A session that it won't heavily subsidize the system. "We regard hardware as the base […]
Meet the worst L.A. free-agent signing ever
There have been a lot of bad free-agent signing in L.A. sports history, but this one rises, or sinks among all the others.
Insider Sale: CEO of Business Group of $BABA Sells 13,579 Shares
Fan (FJ) Jiang, the CEO of Business Group of $BABA, sold 13,579 shares of the company on 06-25-2026 for an estimated $164,305. We received data on the trade from a recent SEC filing. This was a sale of approximately 2.4% of their shares of this class of stock. Following this trade, they now own 556,617 shares of this class of $BABA stock.$BABA Insider Trading Activity$BABA insiders have traded $BABA stock on the open market 7 times in the past 6
Behind the scenes with Jon Ossoff, the 2026 — and maybe 2028
Outside the frame of the viral clips – shot by two cameras carefully positioned on either side of the stage – were over a thousand people, hot under the tin roof of a converted ironworks on Saturday afternoon. They applauded a few times and got one “USA! USA!” chant briefly going, but mostly they sat quietly listening as Georgia Sen. Jon Ossoff spoke.
Movies, books, art and music to explore as America turns 250
As America celebrates 250 years, we size up how it’s been portrayed in, and has shaped, what we watch, listen to and read.
Moving ‘Casey and Diana’ plumbs the messy layers of hope
Nick Green’s dramatization of Princess Diana’s visit to an AIDS hospice is darkly funny and life-affirming, onstage at American Players Theatre through Sept. 24.
2026 BET Awards: The 5 biggest moments of celebration and remembrance
Family and sisterhood were on display at the 2026 BET Awards at the Peacock Theater with wins for Cardi B, SZA and Doechii, and tributes to D'Angelo and Lauryn Hill.
At 99, this Pasadena ballet teacher has no plans to stop dancing
Helga Monson de Kansky was once predicted to become ballet's next star. Instead, she chose a life with her family and a career as a dance instructor.
Wisconsin moms on Medicaid now get 12 months of coverage
Wisconsin’s new law extends mothers’ Medicaid coverage for a full year after birth. Medical experts say it will save lives.
Nancy Pelosi's post-Congress plan: Launching UC Berkeley politics institute
Rep. Nancy Pelosi will launch a multimillion-dollar politics institute at UC Berkeley when she leaves office, co-teaching a course on Congress and hosting visiting fellows from across the political spectrum.
South Korean tech giants to build a $518 billion chipmaking hub to serve soaring AI demand
South Korean tech giants Samsung Electronics and SK Hynix plan to invest a combined $518 billion in a new computer chip manufacturing hub, capitalizing on surging artificial intelligence-driven demand.
Raveheart by Graeme Armstrong review – ravers rebel in a Scottish political satire
A veteran techno DJ embarks on a campaign of civil disobedience in this passionate and at times hilarious tale of underground resistance
Platner Has Slight Edge Over Collins in Tight Maine Senate Race, Poll Finds
The Maine race, which both parties see as key to winning control of the Senate, is extremely close as the sprint to fall begins, a Times/Portland Press Herald/Siena poll found.
John Oliver scores his dream job: A soap opera gig on 'General Hospital'
The host of HBO's "Last Week Tonight" will realize one of his big wishes in July with a guest spot on the ABC soap opera "General Hospital."
Photo highlights of the BET Awards
LOS ANGELES (AP) — The BET Awards, which honor achievements in Black entertainment, sports and culture, aired Sunday with comedian Druski becoming the youngest host at age 31. The live show aired from the Peacock Theater in Los Angeles. ___...
Editorial: Keep up congressional pushback against Trump’s anti-science agenda
For about a decade, hundreds of deep-sea buoys off America’s coasts have been monitoring the conditions of the Pacific and Atlantic oceans. The streams of publicly available data they produce inform weather reports, generate valuable information about the planet’s changing climate and help the maritime industry and even the military maneuver the high seas.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Claims GTA 6 is selling 8 times as many copies on PS5 as Xbox "doesn't represent pre-order data", insists Microsoft
Microsoft has refuted claims that its rival system, the PlayStation 5, is outselling the Xbox edition of Grand Theft Auto 6 by a rate of 8-to-1.
Entertainment Firms Face AI Copyright Uncertainty
Editorial analysis: For AI and ML practitioners, unclear copyright rules raise the legal risk and compliance cost of using generative models in production content pipelines. According to The Economic Times, Indian entertainment firms are investing heavily in AI for content creation, but current copyright law, which is tied to human creativity, may not clearly protect AI-assisted or AI-generated works. The Economic Times reports lawyers warn that, without specific legislation or case law, such works face risks of duplication and misuse, complicating licensing, attribution, and monetization for studios and creators. The article highlights that creators and rights holders in India currently have limited legal recourse under existing statutes, per The Economic Times.
Second Measles Case of 2026 Confirmed by Wyoming Department of Health
The Wyoming Department of Health (WDH) has confirmed a case of measles in an unvaccinated adult from Teton County. Measles is a highly contagious infection that can cause severe illness. The public may have been exposed to measles at the following locations and times: Cafe Court Pizzeria and Ranch House Restaurant, Colter Bay Village, Grand […]
Seattle's data center moratorium: symbolic politics, real costs
With its data center moratorium, Seattle just put the whole city on the wrong side of the new digital divide — and its poorest residents will feel it most.
'The fate of Earth depends on a delicate balance': Our planet may survive the death of the sun after all, new models hint
When the sun dies, it will become hundreds of times its current size and engulf the innermost planets. Earth may escape this infernal fate, according to state-of-the-art stellar evolution models.
Amazon seller reveals rare glimpse of shadow bribery market
An international black market has been a persistent scourge of Amazon's online store.
Humor laurels for comedian Bill Maher as the Kennedy Center navigates Trump-era upheaval
Comedian Bill Maher is set to receive the Mark Twain Prize for American Humor at the Kennedy Center.
Swipeless online dating? How AI is reshaping the search for love
Traditional dating apps including Tinder, Grindr and Bumble and California startups are experimenting with how AI could reshape how people find love online.
Astronomers find biggest super-puff planets yet, lighter than cotton candy
Comparable to shaving foam, astronomers find the wispiest planets yet. They're in the southern "flying fish" constellation.
Costs of Iran war will linger despite conflict's end, experts say
The effects of the war and other factors driving inflation are likely to stick around for months, experts say, presenting an ongoing challenge to American households.
Today's NYT Connections: Sports Edition Hints, Answers for June 28 #643
Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.
BET Awards: Druski to make history as youngest host as show honors Lauryn Hill and Teyana Taylor
Druski will make history as the youngest host of the BET Awards on Sunday.
The Blogs: Mamdani and the Politics of ‘Monsters’
From the blog of Joe Bergovoy at The Times of Israel
Calls for Radical Reinvention of the Tour de France amid Concerns for Rider Health
New Tour race times and new dates are being argued for over fears of heat-related risks.
Millions drop Affordable Care Act coverage after subsidies expired
New federal figures show that about 3 million fewer people had Affordable Care Act health insurance plans in February compared with the same time last year.
Usha Vance pokes fun at ‘political significance’ of maternity dress
Second lady Usha Vance poked fun at a New York Times article examining the public image of pregnant women in President Trump’s orbit, joking that she did not realize her maternity dress carried so …
Madonna makes rare reveal of 1 major pop diva she was 'jealous' of
Madonna recently revealed why she was 'jealous' of Kylie Minogue, even though she wore a T-shirt bearing the 'Can't Get You Out of My Head' singer's name to the MTV Music Awards in 2000.
Best investments over the past 100 years? Almost all are tech companies
Most of the top performers are tech companies, headed by Apple, Nvidia and Microsoft.
Can Gov. Ferguson heat up WA's cooling economy?
Amid rising concerns over a cooling economy – and criticism of the state's negative business climate – Ferguson is looking for help from Amazon, Boeing and other big employers.
Recent rulings show that SCOTUS has ditched reason for politics
'The flurry of 6-3 decisions shows how SCOTUS has become a political body, not the judicial one the founders of our Constitution sorely aspired to,' writes an L.A. Times reader.
Which coach helped Dianna Russini get out of a ticket?
The recent New York Times article regarding former New York Times reporter Dianna Russini answered some lingering questions.
How to Watch the World Cup Today: Schedule, Times, TV, Streaming for Argentina, England, Portugal, More
Argentina, England, Portugal and more close out group stage play today at the 2026 FIFA World Cup. All 6 matches air on FOX and FS1.
Are ghosts real? What top scientists secretly found will shock you - Futura-Sciences
The Enigma of Cryptozoology Cryptozoology is the study of animals whose existence hasn’t been scientifically proven. Think about it: creatures like the Yeti, the Loch Ness Monster, or the giant squid. Sometimes these beings seem straight out of outlandish legends—a touch of myth, a dash of curiosity, and a sprinkle...
Scratching that bug bite might feel good at first but science explains why it’s a bad idea
You scratched that bug bite and now it's a big itchier bump.
Scratching that bug bite might feel good at first but science explains why it's a bad idea
You’ve likely heard it since childhood: Don’t scratch that bug bite or rash, you’ll make it worse. A lot of things can cause itchiness, sometimes serious diseases. Whatever the cause, doctors have l...
Cameron Carr discusses joining the Lakers
NBA mock drafts projected Cameron Carr getting selected between 15 and 20 in the first round. Ending up with the Lakers was more than he could have asked for.
Letters to Sports: Is Austin Reaves worth the $185-million deal?
L.A. Times readers weigh in on the re-signing of Lakers guard Austin Reaves, as well as the Dodgers' hits and misses.
Lions announce 2026 training camp fan schedule, times
Here's when fans can catch the Detroit Lions during 2026 training camp.
California health insurance tax hike: Will your premiums increase?
A balance act: To help fund the safety net, lawmakers have voted through a health tax extension that could increase premium costs for Californians with private insurance.
Stars like Mohamed Salah make World Cup magical for Seattle sports fans
Seattle will remember Mohamed Salah after this World Cup comes to an end. This proximity to excellence is part of what makes the tournament so great.
States seek to lower drug prices by targeting the companies that manage them for health plans
Legislators across the U.S. are trying to lower prescription costs by reining in big companies that handle drug coverage for health insurers.
Federal health officials recall chicken, other items in Washington
The Washington State Department of Health recalled chicken, pasta salad and raisins for potentially containing unlisted ingredients.
UC San Diego hosts free Comic-Con events, intersecting health and science through fiction
UC San Diego is holding a badge-free series of comic and science-inspired events in tandem through The Science of Story, from July 21-26.
Seattle’s Pioneer Square lands a new retailer
A bespoke diamond jewelry company opened a store in Pioneer Square. The CEO is optimistic about its future in downtown Seattle.
Intel’s chip business shows signs of life after years of struggle
Not long ago, Intel was seen as Silicon Valley’s fallen icon. Now it is showing signs of a turnaround amid the AI boom.
Cody Johnson’s country music is only getting bigger. On ‘Banks of the Trinity,’ he’ll take you home
Texas born and bred country star Cody Johnson is seeing a surge in new fans after two decades in the industry.
Seattle ups its payout for vandalized small businesses. Is it enough?
For many businesses, the reimbursement "could be the difference between someone making their rent or not, just because this is such a tough time,” said Analog Coffee's owner.
Nevada takes step toward becoming corporate litigation hub with business court pilot program
The Clark County District Court this week announced it has restructured its departments to include a dedicated business court. The restructuring is expected to bring down case adjudication times, and it could help an ongoing effort to transform Nevada into a premier destination for corporate litigation. Judges Maria Gall and Joe Hardy–Departments 9 and 15, […]
In governor's race, voters face stark choice on immigrant healthcare
California’s next governor will face tough decisions on a highly controversial piece of healthcare policy: what to do about health coverage for the more than 1.4 million low-income residents without legal status.
The heatwave hacks that will actually help to keep you cool
Should you wear wet socks to bed or point a fan out the window? Can the ‘Japanese door fan’ technique cool a baking hot car? Here’s what the science says
What could be next for Gakpo?
Following the departure of Mohamed Salah, at least one more attacking signing is expected at Anfield this summer. Liverpool have already signed Victor Munoz from Osasuna for £34.5m and the pursuit of Yan Diomande is heating up. Talented teenager Rio Ngumoha is also set to play a more prominent role, while Florian Wirtz played off the left for Liverpool at times last season and is featuring there for Germany in the World Cup.
Controversial billionaire tax will appear on November ballot
Proponents of a controversial billionaire tax pledge to making sure it appears on the November ballot to backfill federal healthcare funds.
2026 World Cup Is Putting FIFA’s Rules on Political Neutrality to the Test
The World Cup is in full swing across North America, and the U.S. men’s team faces Turkey in its final group round appearance on Thursday. But behind the cheering fans and nail biting matches, FIFA's commitment to political neutrality is put to the test. Marisa sits down with Tariq Panja, global sports correspondent at The New York Times. They dig into the politics behind the games, from restrictions on Iran’s team and President Trump’s unusually close relationship with FIFA president Giann
Justices Clash on Whether Race Played a Role in Trump’s Bid to Deport Haitians
The split mirrored one that has long divided Americans: how seriously to take the president’s loose, provocative and sometimes ugly remarks.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.