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Detroit Tigers book talk, signing to take place on Oct. 14
EAST TAWAS – Detroit Tigers fans will soon have the opportunity to get a book signed by a former Tiger, as a book talk and signing is scheduled to take
Microsoft’s MacBook Pro Rival Is Looking Even More Ridiculous
We thought Microsoft was preparing a wild laptop. Turns out it's preparing two.
Googlebook "Better Together" phone features don't work with Samsung at launch
Googlebooks require Android 17, but Samsung's Android 17 phones won't work yet.
Autodesk names Diana Colella to lead architecture, engineering and construction business
/PRNewswire/ -- Autodesk, Inc. (NASDAQ: ADSK) today announced that Diana Colella has been named executive vice president of its architecture, engineering and...
Apple has a new MacBook Pro coming soon, here's what we know
Apple has a new MacBook Pro coming soon, and it will be one of the biggest updates ever. Here's everything we know right now.
‘A Mother’s Brain’ explores the neuroscience of motherhood
Neuroscientist Susana Carmona’s book guides readers through a new mom’s changing brain.
Googlebook’s Android-integrated features won’t work with Samsung phones at launch
Googlebook is here with Android integration as its main pitch, but Samsung users are left out at launch as Galaxy devices aren't supported yet
Virginia Housing CEO Tammy Neale Recognized As Virginia Business Women in Leadership Honoree
/PRNewswire/ -- Virginia Business has selected Virginia Housing CEO Tammy Neale as a 2026 Women in Leadership awardee. The Women in Leadership Awards recognize...
Apple's Entire Mac Lineup Gets Massive Discounts for Prime Day
Prime Big Deal Days is in full swing, and we've already begun tracking the best Apple discounts during Amazon's big fall event. This year, there are notable markdowns across Apple's Mac lineup, including the MacBook Air, MacBook Pro, and brand new Mac mini and Mac Studio. MacBook Air Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Disney star Christy Carlson Romano talks new book, stage moms, more
Christy Carlson Romano knows how to play a role, but finding herself has proven to be her greatest performance.
I can’t use Apple’s new Screen Time on my daughter’s iPhone because my son won’t update his MacBook
Kids: 1 Screen Time: 0
AMN Healthcare Research Links Hospital Digital Investment to Better Patient Experience
/PRNewswire/ -- New proprietary research from AMN Healthcare, the leader and innovator in total talent solutions for healthcare organizations, examines the...
Into the Slaughterverse: How ‘Something Is Killing the Children’ cut into film, TV, and books
Into the Slaughterverse! ‘Something Is Killing the Children’ creator James Tynion IV talks expanding his comics into a horror universe with a film, animated TV show, and prequel novel.
Tyra Banks re-releasing viral ‘Modelland’ book 15 years after it failed (exclusive)
Tyra Banks exclusively reveals to EW that she’s re-releasing her ‘Modelland’ book after its viral resurgence online amid her mom’s secret health battle: ‘A deep, almost depression for me.’
Compass Datacenters Funds New Community Wellness Space at Hoffman Estates Health and Human Services
$50,000 investment will create the department's first purpose-built room for group therapy, workshops and community programming Compass Datacenters is funding...
MyVisito Expands Digital Business Cards From Contact Sharing to Bookings, Sales and Connections
One shareable digital card brings professional presence, bookings, sales, events and ongoing connections together, with no app required for the recipient.DOVER, DE / ACCESS Newswire / October 6, 2026 / today announced an expansion of its digital business card platform beyond contact sharing, bringing professional presence, bookings, sales, events and ongoing connections into the same shareable card.
Oprah Winfrey taps a 'riveting' debut novel for her book club
Oprah Winfrey has chosen Amanda Rizkalla's debut novel, “Hungered,” as her new book club pick. The novel, released in May, follows a 12-year-old girl navigating poverty and family struggles. Winfrey
Oprah Winfrey taps a 'riveting' debut novel for her book club
Oprah Winfrey has chosen Amanda Rizkalla's debut novel, “Hungered,” as her new book club pick | 830 WCCO
The New Four Horsemen: Science Created Our Modern Apocalypse — and Science Can Help Prevent It
The Four Horsemen of the Apocalypse — Conquest, War, Famine, and Death — were originally symbolic figures in the Book of Revelation, meant to warn early
Going International: How Global South Journalists Can Elevate Local Science Stories
For journalists in the Global South, access to local science presents an opportunity to bring this knowledge to a wider audience via international outlets. Regional studies and perspectives can inform broader conversations about science, highlight multinational patterns, and elevate research conducted outside of traditional scientific centers. This story offers strategies to find stories, connect with international editors, and meet the needs of audiences that may know little about the place where a story is unfolding.
OVG To Operate, Book Riverview Health Arena in Noblesville, Ind.
The City of Noblesville, Indiana, has announced that Oak View Group will operate and book the 3,400-seat Riverview Health Arena at Innovation Mile. The arena
DarioHealth Announces Independent Aon Analysis that Supports Estimated 2.5%-7.2% In-Year Reduction in Total Healthcare Costs
A component study of the independent review by Aon found $5,077 in annual savings and 23.5% fewer inpatient discharges per Dario user with type 2 diabetes...
FT and Standard Chartered Book of the Year Award 2026
Contenders include titles on weight-loss drugs, AI weaponry and forecasting
FT and Standard Chartered Book of the Year Award 2026
Contenders include titles on weight-loss drugs, AI weaponry and forecasting
Mama Mia Magic Celebrates 20+ Years of Bringing Magic and Entertainment to South Florida
Miami magician Mama Mia Magic celebrates more than 20 years of bringing magic shows, characters and party entertainment to South Florida.
As Taiwan expands Arizona chip plant, China warns against developing political ties
The world's biggest chipmaker now manufactures at scale in Phoenix, as well as Taiwan. China is warning political leaders in Arizona to not get too friendly.
Over 50 former deputy attorneys general endorse AG Raul Labrador’s opponent
The officials, including former Idaho Attorney General Lawrence Wasden, said Labrador had politicized the office.
What are ‘sleeping beauties’ in the world of knowledge?
In a new book, artist David Byrne explores how important ideas are forgotten—and then remembered—over time.
Jeffrey Archer, UK novelist and former politician jailed for lying in libel case, dies at 86
Jeffrey Archer, a British bestselling author who sold more than 300 million book copies in his career and a former politician who was jailed for lying in a high-profile libel case, died Monday.
I review AirPods, MacBooks and more. Here are the 9 best Amazon Prime Day Apple deals
Our tech reviewer has tested tons of Apple gear and is separating the wheat from the chaff when it comes to Amazon’s October Prime Day deals.
Best Prime Big Deal Days Tech & Apple Deals 2026
Shop the best tech and Apple deals during Amazon’s Prime Big Deal Days. Save big on AirPods, Apple Watch, MacBooks, headphones and more top gadgets.
Northwest Biotherapeutics Announces Keynote Presentation on Harnessing Immunity: A Personalized, Multi-Target Approach to Cancer At the UK National Health Service Annual Oncology Conference
/PRNewswire/ -- Northwest Biotherapeutics (OTCQB:NWBO) (the "Company" or "NWBio"), a biotechnology company developing DCVax® personalized immune therapies for...
Second October 'event' possible with new Macs as the focus
Apple already has an unannounced product reveal expected on October 13 and rumors suggest a second round of releases could occur by the end of the month.
Sen. Booker: Trump was ‘scared straight’ on voting by mail
The Best October Prime Day Apple Deals on AirPods, MacBooks, and More
Many Apple’s products are pricier than ever, but we’ve found some decent Prime Day deals on AirTags, AirPods, Apple Watches, and more.
Week 6 honor roll for Central Texas high school football
Week 6 of the Central Texas high school football season is in the books. Here is the honor roll for the Austin area.
macOS 27.2 reveals new clues about Apple’s touchscreen MacBook Pro
Apple is widely expected to release a new touchscreen MacBook Pro as soon as this month. This will mark the...
Legends Radio spotlights JB Berkow’s lifelong art passion
JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.
macOS 27.2 Adds Touch Gestures Ahead of MacBook Ultra
macOS Golden Gate 27.2 adds code referencing new touch-specific gestures in apps like Safari, Notes, Photos, and Quick Look, a possible sign Apple is preparing to release the rumored OLED touchscreen MacBook, possibly called the "MacBook Ultra". Code in the latest beta adds new gesture recognition tools to several Apple apps.
Author and disgraced politician Jeffrey Archer dies aged 86
His last book, Adam and Eve, is set to release this month.
The Googlebook era is here: some first impressions of the hardware and a whole new OS
Today is the day. After months of tracking code commits, dissecting leaks, and getting that unforgettable first taste at Google’s media showcase in New York City, Googlebooks are officially landing...
Doctors, insurers sue Newsom over health insurance premium increases
Doctors and health insurers have filed suit alleging Gov. Gavin Newsom and the California Legislature violated the law when they approved a healthcare tax that could substantially increase insurance premiums.
Sen. Tillis says his vote for Hegseth was 'biggest regret of my career' in new book
Republican Sen. Thom Tillis says in a new book that his deciding vote to confirm Defense Secretary Pete Hegseth in January 2025 is the “biggest regret of my career” and that he also “should’ve stopped” Robert F. Kennedy Jr. from becoming Health and Human Services secretary in the early days of President Donald Trump’s second term.
Fantasy Football Waiver Wire: 9 Must-Adds for Week 5
Week 4 on the 2026 NFL schedule is nearly in the books, and fantasy football managers can start pivoting toward Week 5. It also marks the start of a particular bane of fantasy managers' existence for the year: bye weeks. Just two teams, the Carolina Panthers and Kansas City Chiefs, are idle in Week 5, …
Nicklaus Children's Health System Honored with Inaugural Champion for Children's Care Award from Joint Commission
/PRNewswire/ -- Nicklaus Children's Health System is pleased to announce that it has been recognized with the inaugural Champion for Children's Care Award from...
The upcoming D&D interpretation of World of Warcraft sounds great, but don't expect it to work like the MMO does
World of Warcraft is being given the Dungeons & Dragons treatment in a massive new book. But D&D: WoW works quite differently to the MMO.
Googlebooks with Intel chipsets might have trouble with ‘complex’ Android apps
According to a statement from Google, Intel-based Googlebooks will apparently still struggle with some Android apps. When Android apps made...
Holiday magic returns with sugar sparkle at holiday event
Holiday magic is getting a storybook twist when Quantum House brings back Sugar Plum Dreams.
10 cool and cozy books for fall - Entertainment
Temperatures are cool, the couch is cozy, and the season’s greatest reads are calling your name. Here are 10 books to curl up with this fall.
Misericordia University to Host Healthcare Symposium with Presenting Sponsor Geisinger
Misericordia University’s College of Health Sciences and Education, with Geisinger as Presenting Sponsor, will host the 2026 Healthcare Symposium, “Connected Care: Aligning Education, Innovation & Community Health,” on Friday, Oct. 23, from 8 a.m. to 5 p.m. in Lemmond Theater on the University’s Dallas campus.
Entertainment, work, study: 6 reasons the Dell XPS 13 is an everyday laptop worth looking at
The XPS 13 is a smart choice of notebook to cover all your daily needs
Can Health Trackers Help You Manage Menopause Symptoms?
Apple, Oura and Whoop have all recently added features for midlife women. Here’s what the tools can — and can’t — measure.
PRO SHOP RAISES $24 MILLION SERIES B TO ACCELERATE NEXT PHASE OF GROWTH ACROSS MEDIA, ENTERTAINMENT AND COMMERCE
/PRNewswire/ -- Pro Shop, the innovative media platform connecting golf with mainstream culture, today announced the closing of a $24 million Series B...
Windows 11 26H2 brings a hidden performance boost — and may slash RAM usage
Windows 11 26H2 quietly brings several performance improvements, including a Low Latency Profile that makes common tasks feel faster. Some users are also reporting lower RAM usage after the update, although Microsoft has not confirmed that 26H2 itself is responsible.
Inspired By My Love Of STEM, I Collaborated With 22 Teens To Write A Kids Picture Book About Science
Teen STEM student Eliana Miao wrote a picture book about the microbiome and empathy titled "The Brave Fuzzy: A Microbiome Story"
Fantastical’s long-awaited Android debut begins today on Googlebook
After 15 years, Fantastical's acclaimed calendar app is coming to Android, but it's not quite ready for every device just yet.
How do professional astronomers book time on JWST or Hubble?
Proposals are submitted annually by scientists who wish to use these facilities, and are reviewed by the Telescope Allocation Committee.
American College of Lifestyle Medicine welcomes national resolution advancing nature as a foundation for health and well-being
/PRNewswire/ -- The American College of Lifestyle Medicine (ACLM) today welcomed a resolution adopted by the Association of Fish and Wildlife Agencies (AFWA)...
Bluevine and Coverdash Partner to Bring Embedded Business Insurance to Small Businesses
/PRNewswire/ -- Bluevine, the largest small business banking platform in the US* and Coverdash, a leading embedded business insurance provider powering...
Apple Releases MagSafe 3 Charging Cable Firmware Update
For the first time since February 2023, Apple has released a firmware update for the MagSafe 3 charging cable for the MacBook Pro and MacBook Air. Specifically, Apple last week released firmware version 3.2.0 for the USB-C to MagSafe 3 Cable. The previous firmware version for the cable was 3.1.12. It is unclear what is included in the latest firmware, as Apple does not publish release notes for this.
Google Admits Some 'Complex' Android Apps Run Poorly On Intel Googlebooks
Android app compatibility on Googlebooks may not be as smooth as previously stated.
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | WBBM Newsradio 780 AM & 105.9 FM
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk 1370
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | KNSS Radio
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk Radio 1210 WPHT
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | 1010 WINS
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago.
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall | WBBM Newsradio 780 AM & 105.9 FM
Pope Francis' diaries to be published next month, revealing reflections on Vatican years
Pope Francis' journal entries from his time in the Vatican and years before will be published this fall | Talk 1370
MobileFuse Receives SBTi Validation for Its Science-Based Emissions Target
/PRNewswire/ -- MobileFuse, a leading advertising and technology platform, today announced that SBTi Services validated its science-based greenhouse gas...
Talkiatry Earns Joint Commission Accreditation for Behavioral Health Care
/PRNewswire/ -- Talkiatry, the nation's largest psychiatric provider group and the preferred in-network psychiatry partner for more than 70 U.S. health...
Tech billionaires are spending millions to reshape California’s Legislature
Tech billionaires funding PACs have enjoyed recent growth in personal and corporate wealth and are spending it to handpick the Legislature.
Jaguars vs. Eagles odds: Opening lines for Week 5 matchup
Sportsbooks project the Jaguars to beat the Eagles next week!
Google admits not every Android app runs great on Intel Googlebooks
‘A small handful’ of apps apparently need some ‘developer tuning.’
Top Links 1245 Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for your support of Chartbook. Your generosity keeps this show on the road. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care:
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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