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Legislators receive science education center proposal
Legislators on the Interim Joint Committee on Education recently expressed interest about boosting Kentucky’s science education while hearing a proposal for the creation of the Kentucky Center for Science Education.
Multiple amiibo Listings Have Apparently Been Spotted On GameStop's Internal Database
New Zelda amiibo were announced yesterday
Dana White Comments on Michael Page’s UFC Future
UFC president Dana White confirmed that the promotion has no interest in re-signing Michael Page after the conclusion of his contract.Page just finished his six-fight UFC contract with a 5-1 record, but his fights were not exciting to watch, and the UFC had no interest in re-signing him.Dana White Confirms Michael Page Is No Longer […] The post Dana White Comments on Michael Page’s UFC Future appeared first on HEAVY.
With AI memes, Trump promotes mythical version of himself as challenges stack up ahead of midterms
President Donald Trump is using memes to portray himself as powerful amid struggles with inflation and international issues.
Columbia women’s basketball reveals 2026-27 non-conference schedule
NEW YORK (PIX11) — The Lions’ den will be full of tough competition this winter. Columbia women’s basketball has revealed its 2026-27 non-conference schedule. In an exclusive reveal with PIX11 Sports, Columbia’s opponents leading into Ivy League play are now written in stone for the new season. Head coach Megan Griffith joined PIX11’s Perry Sook […]
Hawaiian Telcom Unveils Future-Ready Business Fiber Platform Engineered for 10 Gig Connectivity
Hawaiian Telcom announced enhancements to its business fiber internet portfolio, including expanded symmetrical upload and download speeds across Fioptics Business Internet plans and the introduction of Fioptics Advanced WiFi for business customers. Together, these enhancements provide Hawaiʻi businesses with faster, more scalable connectivity backed by a fiber network engineered to support connectivity solutions up to 10 Gig.
Winterville man accused of assaulting women with keyboard, officers at ECU Health Medical Center
A Winterville man has been arrested after warrants say he assaulted several women and officers at ECU Health Medical Center.
25 years after 9/11, activists continue fighting for healthcare
Lila Nordstrom, the author of "Some Kids Left Behind: A Survivor's Fight For Health Care In The Wake Of 9/11," sits down with NY1's Cheryl Wills.
Player Ratings: Real Madrid 2–1 Inter Milan
Thibaut Courtois: 8.5. Seven saves — and that doesn’t include those wiped out by Inter offsides. Both Mourinho and Valverde said afterwards that Courtois deserved to be Man of the Match. They’re right. Denzel Dumfries: 6. Struggled at both ends. To be fair, he received little defensive support beyond Konaté and was consistently isolated against […]
Revival of Hope returns to Winterville with national speakers, mental health workshops
The free, two-day community event will run Friday, Sept. 18, and Saturday, Sept. 19, under a large tent on East Fire Tower Road in Winterville.
Scientists in Chicago remotely controlled a wireless brain implant in South Korea over the internet
"The biggest challenge is demonstrating long-term safety and reliability in the human brain."
Apple wanted the iPhone Ultra to cost $1,999, new report says
But the RAM apocalypse intervened. Apple is holding its big annual iPhone launch event on September 9, and it's widely expected to unveil the iPhone Ultra...
Marin dermatologist dances on edge of show business
Dr. David Laub, a practitioner in Mill Valley, satisfies dual interests in dance and philanthropy.
The set-pieces: Real Madrid 2-1 Inter
Madrid won the first contact from two of their seven deliveries and generated four shots, three of them in the second phase
Midwest Aerial Athletics wins big in Aruba
SIOUX FALLS, S.D. (KELO) —KELOLAND News first took you to Midwest Aerial Athletics back in July. The gym was gearing up to compete on the international stage. “We just competed in Texas, and that was the qualifier for Aruba. So we’re going to Aruba this year and hopefully Australia and then Italy in the next […]
Carlos Augusto: "Never easy playing here, we show character"
Inter leave the Bernabéu defeated in their opening match of the 2026/27 Champions League: despite putting in a great performance and creating a huge number of chances, the Nerazzurri were defeated 2-...
Faculty Focus: Chris Erickson, College of Business
Chris Erickson has spent 40 years at NMSU as an economics professor, researcher and mentor. Erickson, a professor in the Department of Economics, Applied Statistics and International Business in...
Fact-checking Trump's stories about his own 9/11 response
President Donald Trump recounted his response to the Sept. 11, 2001, attacks in an interview and event leading up to the 25th anniversary this week, repeating statements that lack evidence about aiding in the recovery.
Senate Set to Vote to Begin Debate on Protect College Sports Act
Background The Protect College Sports Act of 2026 (PCSA), introduced in the Senate on June 2, 2026, by Senators Ted Cruz (R-TX) and Maria Cantwell (D-WA) and joined by Senators Eric Schmitt (R-MO) and Chris Coons (D-DE), represents a comprehensive federal legislative effort to reshape the governance and economics of intercollegiate athletics, including redistributing the significant media revenues generated by college sports. Reported favorably 19-9 from the Senate Commerce Committee and placed on Senate Calendar No. 449 on June 24, 2026, the PCSA was substantially revised on August 7, 2026 (Senate Amendment 6768). The PCSA arrives against a backdrop of cascading judicial decisions that have systematically dismantled the National Collegiate Athletic Association’s (NCAA) authority to regulate the economics of college sports.
Richarlison Accepts Vasco Offer but Tottenham Loan Limit Blocks Move
Richarlison has reportedly agreed to join Campeonato Brasileiro Série A side Vasco da Gama, but the move can’t proceed because Tottenham Hotspur have already reached their limit for international loans.
Hackers breach F5 BIG-IP APM devices to deploy Linux rootkit
A Linux rootkit targeting devices in F5 BIG-IP APM environments can intercept PHP file loading and inject a fileless web shell directly into memory, avoiding the need to write malicious code to disk.
Arsenal youngster in international tug-of-war
Ceadach O’Neill’s international future remains unresolved, with Northern Ireland and the Republic of Ireland both still possible options for the Arsenal youngster.Photo by Cameron Smith/Getty Imag...
Sony Music Japan President Atsuhiro Iwakami: Interview
Sony Music Japan President Atsuhiro Iwakami shares his thoughts on what it will take for Japanese content to score hits abroad.
US House bill requires criminal background checks on Hollywood sets
A House bill would require criminal background checks for Hollywood set workers who supervise or regularly interact with minors.
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations
The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.
Pamplin+ transforms undergraduate business curriculum into four-year experiential internship
Launching in fall 2026, Pamplin+ transforms the Pamplin College of Business undergraduate experience through hands-on learning, required internships, mandatory agentic AI coursework, and cross-disciplinary corporate projects.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Artist creates pop art paintings for charity
Quiet conversation intermixed with smooth jazz piano at Asbury United Methodist Church on Friday evening, the old sanctuary providing shelter from the pounding rain for the art enthusiasts gathered within.
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
Business Aviation Insight. Reassessing Large-Cabin Value After the Falcon 900LX’s Final Delivery Year
Challenger 650 – Photo Credit: Bombardier The Falcon 900LX and Challenger 650 sit at opposite ends of a large-cabin segment that, on 2026 data, now spans nearly $19 million in …
Brentford's rise 'not finished yet'
From starting his coaching journey with MK Dons in 2015, it took the Ireland international 10 years to become a top-flight manager. "I went on a journey to try to be a head coach, but that wasn't straightforward," Andrews told The Football Interview. Playing his junior football in the Dublin District Schoolboy League, second tier Wolves identified Andrews as a target.
Andy Serkis’ ‘Nevatars’ Brings a New Kind of Storytelling to Venice Immersive
Andy Serkis' Nevatars brings interactive XR storytelling, alongside ambitious projects featuring Margot Robbie, Omar Sy and Mark Ruffalo.
Allegri counts on European 'motivation and adrenaline' for Napoli
Coach Massimiliano Allegri is hoping the arrival of Champions League football can help put Napoli on the right track after back-to-back defeats in Serie A. Victory on the opening day against Genoa has been undermined by successive defeats at the hands of Como and Inter Milan, leaving new boss Allegri looking for a reset when his side welcome Arsenal to Stadio Diego Armando Maradona on Wednesday evening.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — The mother of Caleb Vazquez alleges in her lawsuit that Park Mental Health Treatment of San Diego failed to intervene despite signs that her 18-year-old son posed an imminent threat to himself and others.
U-turn After Manchester United Linked With Elite Celtic Player
It looks like the reports regarding Manchester United's interest in the Celtic player were off the mark.
CONFIRMED lineups: Real Madrid vs Inter Milan, 2026 Champions League
Real Madrid have published their starting lineup for the upcoming match against Inter Milan in the Champions League. STARTING LINEUPS: Real Madrid starting XI: Courtois; Dumfries, Konaté, Huijsen, Cucurella; Valverde, Trent; Brahim, Bellingham, Vinicius; Mbappé. Inter Milan starting XI (TBC): Martínez; Bisseck, Stones, Bastoni; Luis Henrique, Barella, Calhanoglu, Jones, Carlos Ausgusto; Lautaro, Thuram. HOW TO […]
Astronaut Health, Lunar and Earth Photography Fill Crew’s Research Schedule
Exploring astronaut health and photographing the Moon and Earth topped the research schedule for the Expedition 75 crew aboard the International Space Station on Tuesday. The orbital residents also kept up life support maintenance following the departure of cargo spacecraft the day before.
Stand Up for Science Demands Congress Stop Transfer of National Institutes of Health Research Funds to
New petition urges Congress to stop an interagency agreement that would allow health research money to fund War Department’s unspecified priorities.
Stand Up for Science Demands Congress Stop Transfer of National Institutes of Health Research Funds to
New petition urges Congress to stop an interagency agreement that would allow health research money to fund War Department’s unspecified priorities.
OM System PEN Camera Pre-Order Available at Amazon US
The upcoming OM System PEN camera is now available for preorder at Amazon US here. OM SYSTEM PEN preorders Product Description OM SYSTEM PEN is a compact interchangeable-lens camera for travel and everyday photography, designed for people who want high image quality and creative flexibility without carrying a bulky kit. At just 393g, its easy-to-carry…
Hundreds rally to protest the planned closure of the Academy of Natural Sciences museum
The crowd was decidedly intergenerational.
Neither political donations nor special interest groups should dictate policy
Letters: Readers respond to George Monbiot’s article on Andy Burnham and political donations
From California to the Moon: Daniel Rivers and Sally Ashton Explore the Intersections of Art and Science NewsCenter | SJSU
Two new books from San José State faculty take on that question through explorations of environmental justice, space, California history and the possibilities of more just futures.
Aaron Rodgers praises Karl Ravech for ‘phenomenal’ ESPN tenure
Aaron Rodgers loves to hate on ESPN, and the Worldwide Leader may have given him a little more ammunition by parting ways with Karl Ravech. Rodgers was recently interviewed by Adam Schein on his SiriusXM Mad Dog Sports Radio show. At the end of the segment, Schein boldly gave Rodgers the open forum to share…
New Cancer Care Technology at Intermountain Health St. Mary’s Improves Precision and Comfort for Western Colorado Patients
Intermountain Health St. Mary’s Regional Hospital has invested more than $2 million for new equipment and technology to improve quality of care and comfort of their patients receiving cancer care in the Grand Junction area.St. Mary’s Cancer Centers of Colorado purchased a new a new computed tomography (CT) scanner that offers several enhance...
Business internship presentations connect classroom learning to career readiness
Nineteen Penn State Lehigh Valley business students concluded their required summer internships by presenting what they learned to faculty and staff evaluators. The presentations culminated a semester-long process designed to help students connect their academic preparation, workplace experiences and career-readiness skills.
Liverpool’s hunt for a new sporting director: Julian Ward and the standout internal options
FSG president Mike Gordon is leading the search for Richard Hughes' replacement, with both internal and external candidates being considered
Politics Threaten Medical Innovation at NIH
Santa Monica rheumatologist warns that political interference in NIH funding threatens scientific breakthroughs and patient care. Taxpayer dollars should support rigorous peer review, not politics.
Former MSU Interim AD Jon Palumbo Heading to Kentucky
The Spartans’ leadership exodus continues as another top executive reunites with J Batt in Lexington, leaving East Lansing to navigate a shifting front office after months of transition.
Years of Dismissed Pain, One Life-Changing Diagnosis
Bronx, NY – For 15 years, Jennifer Grant endured pelvic pain, severe nausea, and fainting episodes that no doctor could fully explain or treat. Dismissed
Proposed Changes to Head Start Undermine Its Role in Promoting Child Nutrition and Healthy Eating - Food Research & Action Center
Published September 8, 2026 For more than 60 years, Head Start has supported young children during their most important phase of growth and development. For families with limited resources, Head Start is a trusted source of care, education, nutritious meals, and health services. Despite Head Start’s long history of bipartisan support, and demonstrated success, the U.S. Department of Health and Human Services (HHS) has a proposed new […]
Scientists call for joint efforts to preserve nomadic heritage
At the International Scientific and Practical Conference “Cultural Heritage of the World’s Nomadic Peoples: Preservation, Study, and Development”, scholars and experts from 23 countries urged unified action to safeguard the cultural diversity of nomadic peoples and ensure traditions remain alive for future generations, Qazinform News Agency cites Kabar.
Current events: Scientists keep close eye on Atlantic Ocean changes
The year is 2060. London shudders through months of Nordic winter freezes. Across northern Europe, oak and beech forests wither under severe frost and drought, while cereal yields collapse from temperatures ...
From 'Love Hypothesis' to 'Fourth Wing,' 60 BookTok favorites coming to screens
Hollywood is finally catching up to BookTok. The well-read corner of the internet brought decade-old titles back to bestseller lists and new life to bookish communities.
Galaxy Z Fold 8 display corners can bend inward on purpose, Samsung says [Gallery]
The internet is mad. Shocking statement, I know, but this time it’s about a perceived quality control issue on the...
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Hong Kong students drop in global rankings for maths, science and literacy
City’s students drop out of global 10 in Pisa’s science section – the first time since Hong Kong joined international assessment.
The Legend of Zelda: Ocarina of Time remake gameplay finally revealed during 40th anniversary Nintendo Direct, and it looks… interesting
Gameplay has been released for The Legend of Zelda: Ocarina of Time remake during today's 40th anniversary series Nintendo Direct.
Intercard is chosen by Family Entertainment Group for its strategic partnership with Topgolf
ST. LOUIS — Intercard is proud to announce that Family Entertainment Group, one of the nation’s premier developers and operators of entertainment experiences, will use Intercard’s cashless te…
Star Stable Entertainment reduces workforce by 20% to secure long-term future of its multiplayer horse adventure RPG
Interim CEO says by "reducing operating costs and refocusing resources," Star Stable will be in the "best possible position to adapt and grow"
Legal complaint against FIFA to cover impact on women’s schedule
A legal complaint against FIFA has been extended to cover its “abusive conduct” towards the women’s game in Europe. The complaint by the European Leagues umbrella group, which includes the Premier League and Scottish Professional Football League (SPFL) as members, was first lodged with the European Commission in October 2024.
‘VisionQuest’ star Paul Bettany says new series is another ‘massive swing’ (exclusive)
‘VisionQuest’ star Paul Bettany interrogates the ‘intergenerational digital trauma’ of the upcoming Marvel series and talks reuniting with James Spader, who’s back as Ultron.
Union leaders rally around Kathy Castor after she helps save 700 jobs at Tampa International Airport
'Ensuring the safety and security of the flying public is too important to contract out to the lowest bidder.'
Sinclair's Criminally Obsessed to Present "Maternal Mental Health: How the Lindsay Clancy Trial Could Change Treatment" National Town Hall to Air on September 9
BALTIMORE – September 8, 2026 – Sinclair today announced a national town hall examining maternal mental health and the questions surrounding diagnosis, treatment and intervention that have been brought into focus by the Lindsay Clancy trial. Maternal Mental Health: How the Lindsay Clancy Trial Could Change Treatment will stream September 9 across Sinclair’s television station...
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes | KNSS Radio
Ashley St. Clair and Alex Gibney on AI and the dangers of Elon Musk
A new documentary about Elon Musk uses an AI avatar to simulate an interview with him, using real quotes.
Television Host and Entertainment Journalist Josh McBride signs with WME and secures exclusive Acast partnership as The McBride Rewind podcast accelerates national growth
The McBride Rewind, the celebrity interview podcast hosted by television personality Josh McBride, has signed with WME for representation in all areas and entered into an exclusive partnership with Acast, expanding the show's reach as it continues to gain momentum in the entertainment podcast space.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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