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Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Miles Bridges trade details: Hornets send athletic forward to Suns, land Grayson Allen
Phoenix and Charlotte kept the NBA offseason rolling on Sunday, reportedly agreeing to a deal involving some key role players.
Suns trade Grayson Allen, Royce O'Neale for Miles Bridges
The Suns have agreed to trade two key rotation players and a 2033 first-round pick for Hornets forward Miles Bridges and future draft capital.
Blackhawks Announce 19-Player Roster For On-Ice Development Camp
With the 2026 NHL Draft now in the rearview mirror, the Chicago Blackhawks officially announced their 19-player roster for the […] The post Blackhawks Announce 19-Player Roster For On-Ice Development Camp appeared first on Chicago Hockey Now.
NEW Pirates Entertainment CONFIRMED for Mickey's Not-So-Scary Hallowee...
There's a new offering coming to Mickey's Not-So-Scary Halloween Party this year!
On anniversary of disastrous debate, Biden rallies Democrats at a casino
President Joe Biden spent the second anniversary of his disastrous debate performance at a Maryland casino, giving the keynote speech at an annual fundraiser for Maryland Democrats.
New Captain Jack Sparrow Entertainment Coming to 2026 Mickey's Not So Scary Halloween Party
Halfway to the Holidays is over, which can only mean one thing: Halloween is almost here at Walt Disney World!!! Don't roll your eyes or laugh. This isn't a joke. At least, not a funny
Only one workout helped older adults lose fat without losing muscle
A six-month study of more than 120 adults in their 70s found that high-intensity interval training (HIIT) may offer a key advantage over other forms of exercise: it helped reduce body fat while preserving valuable muscle mass. While moderate and low-intensity workouts also led to some fat loss, only HIIT maintained lean muscle, which becomes increasingly important with age.
Only one workout helped older adults lose fat without losing muscle
A six-month study of more than 120 adults in their 70s found that high-intensity interval training (HIIT) may offer a key advantage over other forms of exercise: it helped reduce body fat while preserving valuable muscle mass. While moderate and low-intensity workouts also led to some fat loss, only HIIT maintained lean muscle, which becomes increasingly important with age.
International Business Machines (IBM) Is A Top Stock In Billionaire Richard Chilton’s Filings
International Business Machines Corporation (NYSE:IBM) is one of the 10 Best Stocks to Buy According to Billionaire Richard Chilton. Technology giant International Business Machines Corporation (NYSE:IBM) made a key announcement recently when it announced its 0.7-nanometer chip manufacturing technology. This technology is the most advanced chip manufacturing technology in the world. International Business Machines Corporation […]
GM hires talent from rivals to solve self-driving car problem
GM has made several key executive hires since 2025 and brought back Cruise alums to ramp up its self-driving tech development in personal cars.
Yzerman Explains Why Red Wings Left Traverse City
The post Yzerman Explains Why Red Wings Left Traverse City appeared first on Detroit Hockey Now. The Detroit Red Wings brought to a halt a nearly three-decade tradition this week. The club made the announcement that […] The post Yzerman Explains Why Red Wings Left Traverse City appeared first on Detroit Hockey Now.
Bernstein Says Life Science Sector is Improving, Resumes Thermo Fisher Scientific (TMO) Coverage
Thermo Fisher Scientific Inc. (NYSE:TMO) is included among Billionaire Steven Cohen’s Top 11 Dividend Stock Picks. On June 26, Bernstein resumed coverage of Thermo Fisher Scientific Inc. (NYSE:TMO) with a Market Perform rating. It also set a $520 price target after the analyst returned from maternity leave. In a research note, the firm said “Many […]
Srikanth reaches US Open final; India vs England in hockey Pro League; final day of Inter-State Athletics: Indian Sports LIVE, June 28
Here are all the updates from Indian sports on June 28, 2026.
AbbVie (ABBV) Wins Health Canada Approval for Boey
AbbVie Inc. (NYSE:ABBV) is one of the 12 Most Profitable S&P 500 Stocks to Invest In. On June 23, 2026, Allergan Aesthetics, an AbbVie Inc. (NYSE:ABBV) company, announced that Health Canada approved Boey for the temporary improvement of moderate to severe lines between the eyebrows in adults. Boey is the first and only approved botulinum […]
Morgan Stanley Raises PT on International Business Machines (IBM) Stock
International Business Machines Corporation (NYSE:IBM) is one of the Best Cloud Computing Stocks to Buy According to Hedge Funds. On June 23, Morgan Stanley lifted its price objective on the company’s stock to $267 from $225, and maintained an “Equal Weight” rating on the shares. As per the analyst, Dell and HPE earnings demonstrate that the enterprise server demand […]
Hurricanes Acquire Rights To Top Offensive Blueliner John Carlson
Carolina secures exclusive negotiating rights with the veteran power-play specialist as they look to bolster their defensive core before the free agency market opens.
Hurricanes follow Stanley Cup title by looking at how to improve roster
Carolina doesn't have a lot of free-agency decisions after winning the team's first Stanley Cup title in 20 years.
Bad news: Netflix now wants every single profile in your house to have its own email login
Netflix quietly updates how shared accounts work
Egor Shilov Drafted 43rd Overall By Colorado Avalanche
Penn State hockey commit Egor Shilov was drafted 43rd overall by the Colorado Avalanche in the 2026 NHL Entry Draft: Shilov quickly flew up the NHL Draft radar after an outstanding 2025-26 season with the Victoriaville Tigers of the QMJHL. He had 82 points (32 goals, 50 assists) in the regular season, good for 7th […]
Cowboys Weekend Headlines: History's brink, Quinnen, Parker dilemmas
The Cowboys are looking to avoid an inglorious feat in 2026, while there are close eyes on two key components in the fight.
The NHL's Obsession With No-Trade Clauses: Why Hockey Is The Outlier In North American Sports
No-trade and no-move clauses have become so commonplace in the NHL that many fans assume they are simply part of the business of sports. They aren’t.
Key Colts Playmaker Set to Boost Value in Free Agency?
Indianapolis Colts wide receiver Josh Downs' value could increase greatly between now and next offseason.
Fallout from USMNT loss to Turkey and previewing the Mbappe-Haaland clash
On today’s show, we look back at the United States’ final group stage match against Turkey and evaluate their readiness for the Round of 32. Manchester City insider Sam Lee joins us to preview the tournament’s first true superstar heavyweight clash as Kylian Mbappe and France square off against Erling Haaland and Norway in a battle for Group I supremacy. Plus, The Athletic’s Jay Harris is back in the studio to break down the latest bracketology, advancement percentages, and qualification permutations for Groups G, H, and I using The Athletic’s World Cup Tracker.
Riding Into 2028: On the Midterms Trail, Andy Beshear Eyes a Bigger Prize
The two-term Democratic governor of deep-red Kentucky, in demand as a surrogate in key 2026 races, talks horses, faith and family politics as he considers a run for the White House.
Stenberg Excited To Join Sharks, Believes He’s NHL-Ready
Ivar Stenberg says he is ready to be in the NHL next season. After being drafted No. 2 overall by the San Jose Sharks, he becomes yet another another big-name, highly-skilled player in their under-23 group. “They have something really good going on, so super happy to join a special group,” Stenberg said. The 5-foot-11 […] The post Stenberg Excited To Join Sharks, Believes He’s NHL-Ready appeared first on San Jose Hockey Now.
Trump news at a glance: president tests out a new ‘red scare’ ahead of midterms
Republican strategists believe rise of Mamdani could present opportunity to tag Democrats with most extreme views of the left – key US politics stories from Friday 26 June
Sabres select defenseman Daxon Rudolph in first round of NHL draft
Rudolph played in 68 games with the Prince Albert Raiders of the Western Hockey League last season, scoring 78 points.
CAKE, Smokey Robinson headline annual Memorial Park concert in Omaha on Friday
Crowds began filling the park earlier in the day, with some attendees arriving at dawn to secure their preferred spots.
Carolina Reportedly Shopping Rookie Defenseman Alexander Nikishin
Stung by high contract demands and defensive inconsistencies, the Stanley Cup champions may trade their offensive blueliner to land a multi-time Vezina winner for the crease.
Ohio State Buckeyes projected to land elite offensive lineman
Ohio State sits on the cusp of another top-5 recruiting class, and the Buckeyes could be receiving even more good news this weekend. Four-star Jackson (Miss.) offensive lineman Caden Moss is set to commit Friday night, and the Buckeyes are surging late as the favorite to land him. Over the past 24 hours, Rivals national […]
New for MNSSHP 2026: Captain Jack Sparrow Leads Pirate Entertainment in Adventureland
Captain Jack Sparrow joins MNSSHP 2026 in Adventureland with a new pirate entertainment act. The Rusty Cutlass band has not appeared on any confirmed 2026 lineup yet.
Registration open for 2026 Behavioral Health & Children and Family Services Conference | Health and Human Services North Dakota
Registration is now open for the sixth annual Behavioral Health & Children and Family Services Conference, scheduled for Sept. 14-17 at the Bismarck Event Center and online through a livestream option.The main conference will take place Sept. 15-17, with optional pre- and post-conference sessions offered Sept. 14 and Sept. 17.More than 1,400 in-person attendees and hundreds of virtual participants are expected to take part in keynote presentations, breakout sessions and networking opportunities focused on behavioral health, child welfare, suicide prevention and youth development.
Cumberland Schools Consider Adding Two New Sports
The district could introduce women’s flag football and men’s volleyball during the 2027-28 school year.
Small Business Central to American Prosperity Celebration
House Small Business Committee celebrates small businesses as key to American prosperity ahead of nation's 250th anniversary. Learn why Main Street matters.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Accel Entertainment (ACEL) Expands Louisiana Gaming Footprint Through Truck Stop Casino Acquisition
Accel Entertainment, Inc. (NYSE:ACEL) ranks among the best sin stocks to buy for recession protection. On June 3, Accel Entertainment, Inc. (NYSE:ACEL) strengthened its Louisiana business with the acquisition of Rice Palace Truck Stop Casino in Crowley, adding a high-volume gaming venue that expands the company’s route-based gaming network in another of its strongest growth […]
I own a Turkish restaurant in SF. The World Cup changed my business.
Turkey playing in San Francisco as part of the FIFA World Cup 2026 has brought new customers to one restaurant, Turquaz's owner told Business Insider.
Federal AI security center measure advanced by House Science
A measure that would put into law a key federal office focused on artificial intelligence advanced Thursday out of the House Science, Space and Technology Committee, as part of a slate of AI-focused and data center bills. The committee advanced the bills on a bipartisan basis, but put off potential changes regarding funding levels for […]
Commitment season looming as Ohio State staff awaits
The month of June has been a grind for Ohio State’s coaching staff. Position camps, recruiting visits, and still prioritizing their current roster, the Buckeyes have had zero time off… and that will soon change. Ryan Day and company set to be on vacation in the coming days for a well deserved break, that doesn’t […]
YouTube Shorts Nixes 'Dislikes' And Lets You Double The Playback Speed
YouTube has made several key changes to Shorts by removing dislikes and offering a clear screen mode.
As Colorado votes, rural voter politics could influence key races
Rural doesn’t necessarily mean conservative, and the opinions of these 10 voters run the gamut.
Astros Share Hunter Brown Decision Ahead of Tigers Series
A key roster situation develops as the season continues.
Mental health as both outcome and determinant in climate adaptation
Nature Climate Change - Mental health should not be viewed solely as a passive outcome of climate adaptation. Rather, it serves as a key determinant of cognitive capacity and shapes the...
Blue state leaders erupt after Supreme Court’s decision ending TPS protections for Haitians, Syrians
Supreme Court rules 6-3 in favor of Trump administration in two key immigration cases on Temporary Protected Status and asylum, drawing opposition from blue state Democrats.
2026 World Cup Is Putting FIFA’s Rules on Political Neutrality to the Test
The World Cup is in full swing across North America, and the U.S. men’s team faces Turkey in its final group round appearance on Thursday. But behind the cheering fans and nail biting matches, FIFA's commitment to political neutrality is put to the test. Marisa sits down with Tariq Panja, global sports correspondent at The New York Times. They dig into the politics behind the games, from restrictions on Iran’s team and President Trump’s unusually close relationship with FIFA president Giann
Sports with Sam: FIFA Fan Fest kicks off at Olympic Park: U.S. vs.Turkey
Monkey Business: Wild rhesus macaque spotted at Mount Dora hotel
A wild rhesus macaque was spotted at the historic Lakeside Inn in Mount Dora, Florida, spending about 45 minutes roaming the property and attracting attention from guests and staff. The hotel and local businesses responded with humorous, monkey-themed social media content, engaging the community. Wildlife officials cautioned the public not to approach or feed wild monkeys due to potential health risks and encouraged reporting sightings to authorities. The monkey has not returned to the hotel but has been seen elsewhere in downtown Mount Dora.
Octavia Spencer's Orit Entertainment Names New Heads Of Film & TV
Octavia Spencer's Orit Entertainment has made two key executive hires, naming Kathryn Tyus-Adair as Head of Film and Adam Wagner as Head of Television
Octavia Spencer’s Orit Entertainment Names Kathryn Tyus-Adair Head Of Film & Adam Wagner Head Of Television
EXCLUSIVE: Octavia Spencer’s Orit Entertainment has made two key executive hires, naming Kathryn Tyus-Adair as Head of Film and Adam Wagner as Head of Television. “Kathryn and Adam are exceptional exe...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
12 arrested in South Florida in nationwide investigation into $6.5B health care fraud
Investigators say Medicaid and Medicare thieves in South Florida bilked taxpayers for $27 million for everything from fake therapy to medical equipment patients never received. Officials seized the stolen taxpayer money from Key West to Fort Pierce.
Kurt Zellers Steps Down as CEO of the MN Business Partnership
The former legislator’s tenure in this key role lasted less than three years.
Life Aboard the Langseth: A Q&A With Chief Science Officer Cody Bahlau
On Columbia’s global research vessel, the R/V Marcus G. Langseth, Bahlau serves as the key link between scientists, crewmembers and operations on shore.
Google Finance gets a dedicated app for Android
Users will be able to access their watchlists, real-time market data, live financial news, and Google's AI-powered "Key Moments" feature, which explains why stocks moved.
RFK Jr. urged Iowa candidate to make deal to help GOP win House seat, per audio recording
The health secretary urged Iowa Libertarian candidates to drop out of key races to help Republicans keep control of Congress, according to interviews and a recording obtained by The Post. The effort highlights mounting GOP anxiety over the battle for the House.
Aurora program breaks down barriers to one of the most expensive youth sports
Supreme Court protects pesticides from some health claims in key Roundup case
The Supreme Court on Thursday restricted Americans’ ability to sue pesticide makers over alleged health harms stemming from their products. In a 7-2 ruling, the court held that some claims that pes…
Here’s What It Means to Be a Democratic Socialist
Universal health care, taxing the wealthy and opposition to military aid to Israel are among the movement’s key tenets.
Health systems must shift AI use from automation to transformation
While healthcare investments in AI are two to three times that of other industries, most providers focus AI's power on tackling administrative tasks. But AI's true value is in transforming care, explain experts at the HIMSS AI in Healthcare Forum.
ADUSA tapped a former Amazon exec to helm its business. What does this mean?
The grocery company’s nominee for the top role may raise some eyebrows given Amazon’s brick-and-mortar track record, but Claire Peters' appointment could be the key to further omnichannel growth.
Elizabeth Warren says ‘frenzy’ of mergers under Trump could be reversed
Senator warns of ‘tsunami of anger’ against big companies and suggests future administrations may undo key deals
Palo Alto Networks CEO: Workers are in 'Darwinian moment' with AI
"The challenge right now is 90% of the enterprise employees are not AI savvy," said Palo Alto Networks' CEO, who added that self-teaching is key.
‘Long-term Thinking Is Key To Ensuring Cultural Relevance’: Q’s With Gadget Entertainment Group’s Stefan Wyss
Gadget is one of Switzerland’s longest-standing promoters, having celebrated its 30th anniversary in 2024. In 2020, after already collaborating successfully
Griffin Jax Leads Rays Past Royals 5-3 as Tampa Bay Snaps Two-Game Skid
The Rays snapped their two-game skid with a 5-3 win over the Royals as Griffin Jax continued to shine in the rotation. Tampa Bay also got key contributions from Jonathan Aranda, Yandy Díaz, and Jonny DeLuca, while Bryan Baker locked down his 20th save of the season.
A season of festivals, special events and America 250 celebrations
The Florida Keys is turning up the heat with summer events this season running from Key Largo to Key West. Think local traditions, world-class culinary festivals, and landmark America 250
Closed-door outburst turns into victory for Trump’s Iran negotiations
Senate Republicans flipped to reject Democrats' Iran war powers resolution, handing Trump a key win as U.S.-Iran peace deal talks continue on.
Ohio State star Jeremiah Smith gets first ever notoriety by EA Sports
Ohio State superstar wide receiver Jeremiah Smith has received a first-ever ranking at launch for 'College Football 27' and the folks at EA Sports.
Jaguars roster: Where does DeeJay Dallas fit in backfield?
DeeJay Dallas enters training camp looking to carve out a role in the Jaguars' crowded backfield, with special teams likely playing a key part.
Trump news at a glance: US president holds a rare bipartisan bill hostage
Trump says he’ll sign housing bill aimed at lowering costs only after Senate passes restrictive voting measure – key US politics stories from Wednesday 24 June at a glance
The NHL Is Considering Bringing More Teams to Texas
The NHL has expanded to new areas in recent years, as the North American hockey league has brought teams to Las Vegas, Utah and Seattle. More expansion could be coming. But while hockey is known for its footprint in northern U.S. states and Canada, the league is considering bringing more of it to ...
Lancerlot Sports Center holds ice hockey camp for kids, tweens
Kids from around the Roanoke Valley laced up the skates and glided around the ice at Lancerlot Sports Center in Vinton for the VYHA Dogs Camp Wednesday.
New website names and shames companies that still don't offer passkeys to users
According to a new site, 24% of the most popular websites in the world don't offer support for passkeys, which are considered the most secure way to log into apps and services.
Bosnia and Herzegovina vs. Qatar Live Updates, Score: Who Will Grab 3rd Place In Group B?
Follow Bosnia and Herzegovina vs. Qatar live at the 2026 FIFA World Cup. Real-time score updates, key plays, and match analysis as it happens.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
As Blockbusters Loom, Monkey Business at the Supreme Court
An unlikely trio of justices issued a slashing critique of plea bargains that included several references to orangutans.
Samsung accidentally confirms Galaxy Z Flip 8 chip choice
The Galaxy Z Flip 8 landed in the FCC database a few days ago, but a close look reveals that the filing contains key chip details too.
Federal officials plan to offload some warehouses purchased for immigrant detention
U.S. Immigration and Customs Enforcement is retreating from a plan to use warehouses to hold up to 10,000 people on a single site, dropping a key piece of former Homeland Security Secretary Kristi Noem’s $38-billion plan to rapidly expand detention capacity this year.
Political earthquake: 5 key takeaways from New York’s Democratic primaries
A trio of progressive insurgents backed by New York City Mayor Zohran Mamdani claimed victories in House primaries. Here’s what to know.
Daily Bean: Trades! Trades! Trades! More Rumors, Bruins Draft Board
Where do we begin? The Boston Bruins did not grab any headlines yesterday. They signed P-Bruins goaltender Simon Zajicek to […] The post Daily Bean: Trades! Trades! Trades! More Rumors, Bruins Draft Board appeared first on Boston Hockey Now.
Abortion rights fight underscores key themes in Maine’s U.S. Senate race
Four years ago today, the U.S. Supreme Court overturned Roe vs. Wade. In the majority of that decision was Justice Brett Kavanaugh, who Republican U.S. Sen. Susan Collins of Maine had voted to confirm after he had told her the landmark decision was “settled law.”
Donald Trump has endorsed these candidates in Michigan midterms
President Donald Trump has endorsed Republicans in Michigan's 2026 midterm election, including in key races for U.S. Senate and governor.
Latino voters could be key to midterms. What's driving them? "The economy, and the economy, and the economy."
Where Ohio State ranks among best teams in EA Sports College Football 27: Buckeye Breakfast
Ohio State will be ranked among the top teams in EA Sports College Football 27.
Yankees news: Yanks sign top Taiwanese arm
Yanks land Chien-Fan Lai; a swap at backup catcher and key injury updates; Cole’s rough outing; Boone chides Chisholm
South Coast Business & Technology Awards help fund opportunities
SANTA BARBARA, Calif. (KEYT) The networking reception and the South Coast Business & Technology Awards at the Hilton Santa Barbara Beachfront Resort
Could mountains be key to unlocking hydrogen’s potential?
Researchers assessed likelihood gas was produced during creation of Alps, Pyrenees and Baetic mountains