SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " Ink " 7,603 found 🔀 AI-powered Shuffle
Frequent AI chatbot use linked to belief in anti-vaccine myths, poll finds
Poll finds use of AI tools for health advice is correlated with belief in vaccine falsehoods, such as shots causing autism
The Supreme Court’s trans sports ruling is a cautionary tale for all left-leaning lawyers
If you’re a liberal, and you’re thinking of bringing a case to the Supreme Court, don’t
Recent Research on How Experiencing Racial Discrimination Impacts Health
This brief provides an overview of the relationship between racial discrimination and health and highlights research examining mechanisms underlying health outcomes linked to experiences of racial discrimination, including biological changes, chronic stress, mental health, substance use, pregnancy-related outcomes, and sleep.
Peptides are everywhere in health and beauty, but does the science actually back up the claims?
Peptides are everywhere — promising to fix wrinkles, weight gain, and even torn ligaments. But are they safe? The FDA is moving to expand access. Here's what a medical expert wants you to know. 👇
Rethinking “Soft” Leadership Skills in Public Health
Learn how public health leaders can leverage interpersonal skills to better navigate cross-sector partnerships in this blog post.
Report: Apple Watch Redesign Coming Next Year With New Band System
A "major overhaul" of the Apple Watch's design is due to arrive next year with a new system for connecting bands, according to a known Weibo leaker. In a set of recent posts, the leaker known as "Instant Digital" linked the new claim to older rumors about an "Apple Watch X" model, which was said to introduce a fresh design and break compatibility with the existing watch band system.
'I Don't Know What They're Thinking': Ex-PlayStation Boss Weighs in on Sony's PC Port Backtracking
Porting is all about "mindshare"
Marlee Matlin Signs With Gilbertson Entertainment (EXCLUSIVE)
Academy Award winner Marlee Matlin ('CODA') has inked with Gilbertson Entertainment for management.
What are the Numbers for Ideal Heart Health?
Heart disease remains the leading cause of death in the United States so Dr. Roshini Raj, associate professor at NYU Langone Health, joins TODAY with a look at the five categories, and the ideal numbers for each, linked to optimal heart health.
Not politics as usual. Democratic primaries linked to age, ideals and outside money
In Aurora, voters are deciding Democratic candidates for three county races in two counties, Democratic candidates in two hotly contested state House districts and a Republican nominee in a south-Aurora state Senate district.
Landlord-tenant spat at center of Highland Park's retail losses
Uncharacteristic store closures in popular Highland Park linked to landlord-tenant dispute that's headed to court.
Think Insurance Denials Only Hurt Patients? Why Business Owners Are Paying the Ultimate Price
A simple 9-week delay for a critical medication resulted in a $50,000 surgical nightmare. Here is how healthcare bureaucratic delays quietly destroy your company's bottom line.
What Botox, rat poison and venoms can teach students about science
New University of Nevada, Reno course builds scientific thinking skills for future science-related fields
Henry Winkler says 'there's a string between' him and his 'Happy Days' costar Ron Howard
Winkler and Howard costarred on the '70s sitcom, and they've remained close in the decades since.
AMC Entertainment (AMC) Stock Sinks As Market Gains: What You Should Know
In the most recent trading session, AMC Entertainment (AMC) closed at $2.03, indicating a -6.02% shift from the previous trading day.
Addison Barger Will Be Out Longer
The start of another series, and all I’m thinking is ‘don’t be swept’. That stuff about Addison Barger being back soon? Not so much. He has a ‘stress reaction in his back’. I guess that means stress fracture, but he’ll be shut down for two more weeks. So let’s hope that he might be back […]
Netflix and Superheroes Are Having a Rough Stretch on Streaming....
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) I have a quick prediction before we start today’s article: You might see this data in future news articles. Not my specific charts or analysis, but the core trend I’ve been monitoring—Netflix is having a lackluster Q2—will become inescapable. Often, folks want to know “What does the data say?” Well, that’s what it says. I haven’t seen this analysis hit the trades really yet, but I have a feeling some other outlets are going to start making this case soon. Remember, you read it here first. You probably have read about the problems facing superhero films at the box office this weekend. Well, this week, I explore whether superheroes are dying on TV as well! And the data says: definitely maybe! We have a lot to cover in today’s Streaming Ratings Report, which covers the two weeks of 18-May and 25-May. Today, I’m just looking at TV, like Netflix’s disappointing Q2, superhero shows underwhelming, a few TV shows dropping off the charts, The Pitt finally ending its epic run on the viewership charts (and whether “view counts” change its status as one of the biggest shows of all time), all the flops, bombs and misses, and a whole lot more. Tomorrow, I’ve got a great rundown of the film side of things. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, Showlabs, TV Time trend data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of May 18th to May 31st, 2026. You can find a link to my terminology here.) Subscribe Television - Netflix’s Q2 Slump Continues Having analyzed streaming ratings for going on half a decade, I have learned to trust my gut, but I’m always relieved when I can find actual data to back it up. For example, after a string of very popular shows like Stranger Things, Bridgerton, The Lincoln Lawyer and The Night Agent came out, week after week, in January and February, my gut wondered if Netflix had enough new and returning TV shows to sustain them throughout the year. Since then, Netflix’s post-March slate of shows has not impressed me. This week seemed to feature a potential new hit, but then, like a classic Duffer Bros. TV show, there was a twist. I speak of The Boroughs, Netflix’s latest (and last) Duffer Bros. produced show. The pitch is “Stranger Things with older actors”. And it topped the Nielsen charts: With just two weeks of viewership, The Boroughs would have been a top 25 debut show last year: But here’s the twist: Netflix has already cancelled The Boroughs! What happened? Likely a few things. First, the show didn’t do as well globally as it did in the US. As What’s on Netflix showed, it lagged behind several other shows that got cancelled. Second, its completion rate was likely low; after an initial burst of interest, it quickly dropped off on the Samba TV and Luminate charts. Third, the Duffer Bros. left Netflix for Paramount, and that may have factored into Netflix’s decision here. (Though I tend to believe that if a show is doing well, Netflix would have kept greenlighting seasons.) Still, just because I can explain why Netflix may have cancelled this show doesn’t mean I’m justifying it. In particular, as I’ve noted before, Netflix is losing a lot of their bigger shows as they reach their natural ends, and they need to replace those shows. This show had the hallmarks of a big new genre show, and it’s their biggest hit of the last few months (in the US at least), but now it’s done. Netflix’s other show this week—The Four Seasons, the second season of the “hit” show from last year—definitely disappointed. Its sophomore season had about half the viewership of the first, only 12.7 million hours. It also only had a two week run on Samba TV, and its numbers were all down on Luminate too. In other words, even with two successes, the Q2 slump for Netflix looks real: I could add to the list of disappointments: Both Lord of the Files and Man on Fire had short runs on the Nielsen charts. Running Point’s sophomore season also opened to about half its viewership, similar to The Four Seasons. A Good Girl’s Guide to Murder’s second season—see below—didn’t even make any of the three viewership charts I track, unlike the first season. Netflix is absolutely having a dismal second three months of 2026. If this Nielsen data is any indication, and I think it is, I think this will show up in Netflix’s engagement report, and maybe even their financial outcomes. And the rest of June doesn’t look much better. We have two hit shows coming back—Sweet Magnolias, one of their quietest big shows, and Avatar: The Last Airbender, a big hit for them in 2024—but the other big swings are limited series crime thrillers i.e. no future season potential. Like I said above, sometimes when I uncover a juicy nugget like this, other outlets end up writing very similar articles mimicking the data without credit. We’ll see if that happens this time! Share Television - The State of Superhero Shows on Streaming When I first heard the pitch for Spider-Noir—a Sony TV show on Prime Video that binge-released eight episodes first on MGM+ then on Prime Video two days later—I had my doubts. It’s a live-action Spider-Man show set in the 1930s, starring Nicholas Cage, based on a cameo of a character in Spider-Man: Into the Spider-Verse. No, seriously, that’s the pitch. That could either go terrifically well or horribly wrong. Great because, Spider-Man. He’s the biggest superhero we have. I’ve seen tracking numbers that put the new _Spider-Man: Brand New Da_y as the blockbuster of the year and initial pre-sales back that up. And yet this Spider-Noir pitch feels very esoteric. (Also, the eight-episode binge release feels very “Amazon copying Netflix” again.) So what’s the data say? And what does this say about the future of superhero shows?
Reviews clear Telescope Health of fraud allegations; officials encourage Jacksonville residents to use HealthLink JAX
Multiple reviews have found no evidence of fraud, criminal wrongdoing or misuse of taxpayer dollars by Telescope Health, ending months of scrutiny over the Jacksonville company that operates the city’s HealthLink JAX program for uninsured residents.
Peptides are the latest US health craze. But what exactly are they?
While peptides are taking the health and wellness category by storm for various use cases, what exactly are they? Leerink Partners senior research analyst Michael Cherny helps break down what a peptides are, how people are choosing them for personal health and recovery reasons, and who the biggest winners in consumer pharmaceuticals could be if their popularity continues to grow.
The Most Important Business Lesson From Cannes Had Nothing to Do With Advertising
The world's biggest advertising festival just made the case that creative thinking belongs in the boardroom, not just the campaign brief.
Who Wore It Best: 1
You’d think there’d be more demand from top players for the number 1 on the back of the jersey, especially since it was worn by some notable players. However, it has largely been the designation of contact first, defensively solid infielders over the years and the Jays are no exception. When the Yankees and Indians […]
Jessica Blair Herman Signs With Luber Roklin Entertainment (EXCLUSIVE)
Actress Jessica Blair Herman has inked with Luber Roklin Entertainment for management, Deadline can report exclusively.
Trump voters say costs are crushing their wallets — but look past president for blame
Trump rally attendees say rising gas prices are linked to the Iran conflict, not Trump's policies, and express confidence costs will decline soon.
Growing scientific evidence links e-cigarette chemicals to heart health risks
DALLAS, June 29, 2026 — Is vaping bad for my health? As people who use e-cigarettes and their loved ones pose questions like this, growing scientific evidence shows that the answer is yes. Research studies show that several chemicals found in...
Meet the worst L.A. free-agent signing ever
There have been a lot of bad free-agent signing in L.A. sports history, but this one rises, or sinks among all the others.
Think You Should Wait Before Drinking Your First Cup of Coffee? Science Says There's No Need (or Benefit)
Research shows when you drink your first cup of coffee has no impact on afternoon energy levels. Or hydration. Or anything, aside from how you like to start your day.
People are taking allergy and heartburn pills for PMS. Could it work?
Can the mix really help with premenstrual woes? Theoretically, the link between histamine and hormones could explain why the trendy DIY treatment seems to help some women.
Investor Clive Meanwell on designing biotechs for population health, and AI's role as a catalyst
Clive Meanwell, chairman of investment firm Population Health Partners, was an AI skeptic until recently. Now, he thinks it's a catalyst.
Andretti linked to young rising IndyCar driver for 2027 season
Andretti Global has been linked to a young rising IndyCar driver for the 2027 NTT IndyCar Series season.
Jose Mourinho eyes Chelsea mainstay as his ‘priority’ signing
Former Real Madrid manager Xabi Alonso has taken over the reins as Chelsea’s new coach and is already planning the squad and his dynamics for the upcoming season.The revolutionary thinker that he is...
Restructuring safety
The real question isn’t whether safety survives a restructuring; it’s where the cracks appear first – and whether anyone is looking.
Elon Musk shares Armie Hammer comeback film banned in Germany for violent anti-immigrant imagery
Elon Musk shared a link to stream Uwe Boll's 'Citizen Vigilante' in its entirety. The Armie Hammer comeback vehicle was effectively banned from distribution in Germany due to violent anti-immigrant imagery.
I grew up in China, but I'm raising my daughter in LA. A trip back to visit family made me rethink my parenting style.
About 170,000 people in England expected to die from obesity-linked heart conditions by 2035
British Heart Foundation finds about 45 people a day expected to die over next decade if current trends continue
John West: Science and the American Founding
“Today, many people think that belief in a Creator is a subjective preference based on their personal faith. But that was not the view of America’s Founders.”
Boston Celtics Daily Links 6/28/26
All the Celtics news you need in one convenient place.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
I spent weeks thinking my Pixel's camera lens was smeared before discovering the real culprit
I can finally take good pictures again!
Why did this journal retract two 1940s papers by Max Planck?
Clicking on the links now reveals blank pages and empty PDFs. "Intellectually, it’s not acceptable.”...
A brief history of same-named political candidates, election hijinks and Dan Sullivans in Alaska
The kerfuffle surrounding the Alaska Senate race isn’t the first time two Dan Sullivan candidates have wound up on the same ballot.
England players use new sports drink to help beat extreme heat at World Cup
The Football Association placed a large order for a sports drink produced by a company owned by the double Olympic triathlon champion Alistair Brownlee which helps to control body temperature
Govee's smart nugget ice maker makes every iced drink feel like a luxury
For some people, the ice in a beverage is almost as important as the drink itself. That's the audience Govee had in mind when designing its latest ice
30-Day Challenge: All-Time Favorite Bears Defensive Back
Each day in June, we’ll roll out a fresh topic to get Bears fans thinking in our 30 Day Challenge, and today we want to know your all-time favorite defensive back.
Jodi's Journal: The purple city prevails
No matter who emerges in this election, the purple city has prevailed. And I think that's a win.
Brain activity under anesthesia challenges what we know about consciousness
The unconscious brain appears to be far more capable than scientists once believed. Researchers found that patients under general anesthesia could still process language at a sophisticated level, distinguishing nouns, verbs, and adjectives while listening to stories. Even more remarkably, neural activity showed signs of predicting upcoming words before they were heard. The results challenge traditional ideas about consciousness and hint at new possibilities for brain-computer interfaces.
Common pesticide linked to more than double the risk of Parkinson’s disease
Scientists at UCLA have linked long-term exposure to the pesticide chlorpyrifos with a sharply increased risk of Parkinson’s disease. People exposed to the chemical near their homes were more than twice as likely to develop the condition. Laboratory studies showed that chlorpyrifos damages dopamine neurons and interferes with the brain’s ability to remove toxic protein buildup.
Ex-Google engineer says Larry Page, Sergey Brin and Sundar Pichai share the same trait—it’s the lesson he swears by as a $7.2 billion AI CEO
$7.2 billion AI founder Arvind Jain ‘observed’ Sundar Pichai at Google for years before he became CEO—he learned you need to ‘think crazy’ to be successful
Ex-Google engineer says Larry Page, Sergey Brin and Sundar Pichai share the same trait—it’s the lesson he swears by as a $7.2 billion AI CEO
$7.2 billion AI founder Arvind Jain ‘observed’ Sundar Pichai at Google for years before he became CEO—and learned you need to ‘think crazy’ to be successful
After trying a Google TV projector, I may never buy another TV ever again
After spending a few weeks with a Google TV projector, I think I may be done buying actual TVs for good. Here's what changed.
Shingles is linked to inflammation in the brain. Research shows how to cut dementia risk.
Shingles, a condition triggered by the reactivation of the varicella-zoster virus in the body, can cause a “war zone” of inflammation in the brain.
Pols & Politics: Why not make looser drinking laws for World Cup permanent, observers ask
Massachusetts relaxed its rules on public drinking to accommodate World Cup fans. One libertarian magazine is wondering why it isn’t permanent. Plus: Lawsuit to compel audit being considered.
‘AIDS is not over:’ Behind a local group’s awareness campaign for HIV funding
Walk through East Liberty, Bloomfield or other Pittsburgh neighborhoods and you might see flyers with black-and-pink block print and an urgent message:...
Report: Rockets have been linked to Lakers' Marcus Smart
The Rockets reportedly have interest in signing Marcus Smart away from the Lakers if he declines his player option for next season.
‘Noxious odors’ lawsuit involving organic residuals lagoon dropped by Fort Smith business owners
VAN BUREN -- A civil lawsuit focused on a widespread foul odor linked to an Arkansas River bottom organic residuals storage lagoon has been dismissed at the request of the plaintiffs.
A Giant Scorpion the Size of a Coffee Table Is Forcing Scientists To Rethink Evolution
Praearcturus gigas was a meter-long Devonian scorpion whose size may reflect a world with few large competitors rather than high oxygen alone.
Shelby County Health Dept. offers free HIV testing
In honor of National HIV Testing Day, the Shelby County Health Department hosted free testing on Saturday, and they urged anyone thinking about getting tested to do it now.
The Simplest Focus Booster Is Sitting in Your Drawer Right Now
Science shows that writing by hand strengthens the brain by improving memory, focus, and deep thinking compared to typing.
Venezuela Quakes Push Fragile Health System to the Brink
Earthquake victims are overwhelming healthcare centers in Venezuela’s coastal state of La Guaira and beyond, pushing an already fragile health system past its limits.
Cowboys Weekend Headlines: History's brink, Quinnen, Parker dilemmas
The Cowboys are looking to avoid an inglorious feat in 2026, while there are close eyes on two key components in the fight.
Are ghosts real? What top scientists secretly found will shock you - Futura-Sciences
The Enigma of Cryptozoology Cryptozoology is the study of animals whose existence hasn’t been scientifically proven. Think about it: creatures like the Yeti, the Loch Ness Monster, or the giant squid. Sometimes these beings seem straight out of outlandish legends—a touch of myth, a dash of curiosity, and a sprinkle...
4 Foods and Drinks With More Calcium Than Yogurt
Yogurt is a calcium-rich food. However, other foods and drinks, such as tofu and kefir, contain even higher amounts of calcium.
Raptor discovery in Argentina points to prehistoric links with China
Unearthed on opposite sides of the world, fossils of Kank australis and velociraptors sport matching claws, revealing evolutionary ties.
Why the CEO of AllianceBernstein says you should worry about an AI bubble
"Is it likely we have a meaningful correction? I think it is," AllianceBernstein's CEO told Business Insider in an interview.
The Best Diet For Brain Health Is Probably Not What You Think
There was one clear, standout winner.
"People think science is about the truth. It's not" – Why everything we know about the Universe could be mere guesswork | BBC Sky at Night Magazine
Are space science, cosmology and astronomy just guesswork? Considering the purpose of science and how we study the Universe.
How this A-lister ended up in 'Supergirl'
Yes, that 'Supergirl' cameo is who you think it is. Director Craig Gillespie and star Milly Alcock talk about how it came together.
Axios Live: "Health care costs are scaring people," Rep. Dingell says
Americans are not just thinking about the high prices of health care — they're afraid of them
Downtown Largo could become an open-container entertainment district
Downtown Largo could allow open-container drinking, outdoor entertainment and live music under a proposed entertainment district.
Scientists Baffled by Discovery of Rare “Pink Floyd” Spider Hidden in Home Walls - Futura-Sciences
The Birth of a “Pink Floyd” Spider Tiny, discreet, and quietly settled on urban walls, a new species of spider was recently discovered in Colombia—and christened as a tribute to the iconic rock band Pink Floyd. As part of a study published in the journal Zoosystematics and Evolution, South American...
Elisee Junior St. Preux Signs With Evoke Entertainment (EXCLUSIVE)
Filmmaker Elisee Junior St. Preux has inked with Evoke Entertainment for management, Deadline can report exclusively.
Why where you live matters for heart health — even in childhood - Baylor College of Medicine Blog Network
Evidence links environmental exposures to early cardiovascular risk, disproportionately impacting marginalized communities like AI/AN youth.
Scientists stunned by signs of ancient life in a place no one expected
Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.
Starlink veterans launch startup to broaden megaconstellation ownership
Former SpaceX engineers who helped build and scale Starlink have launched a startup aiming to deliver megaconstellations for governments and companies seeking more control over space-based infrastructure.
What Happens to Your Liver When You Drink Green Tea Every Day
What does green tea do for your liver? Learn how it may affect fat buildup, inflammation, and liver enzymes, plus risks and benefits.
New York Jets News: Geno Smith Needs Another Career Comeback
Your daily links to the New York Jets
Bayer wins in US court, but at what cost to public health?
A landmark US Supreme Court ruling protects Bayer from thousands of lawsuits linked to its Roundup weedkiller. Plaintiffs alleged the German agrochemical giant failed to warn users about potential cancer risks.
Heat Wave Prompts Paris to Suspend Sports Events and Public Drinking
The Paris police chief, Patrice Faure, said that alcohol restrictions were intended to ease pressure on health services.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Introducing: Breguet Celebrates the 225th Anniversary of the Tourbillon with Four New Releases, And the Return of a Collector Favorite (Live Pics)
A revived and revised version of the Roth-designed caliber 558.1 movement (significantly improved) headlines four watches to celebrate the patent date of one of Abraham-Louis Breguet's most notable achievements.
UK food and drink exports fall as US tariffs and Brexit trade friction bites
Rolling coverage of the latest economic and financial news
EVA HENRY: Corruption resurfaces in Adams, Arapahoe County politics linked to One Main Street
Corporate dark money groups are funneling millions into eleven different races statewide.
233-acre Franklin farm could become major youth sports complex
A Nashville Predators-operated ice rink and athletic facility could transform historic Franklin property.
Growing sinkhole in Houston's Third Ward raising safety concerns for business owner, neighbor
A growing sinkhole behind a property on Scott Street in Houston’s Third Ward is raising concerns for a longtime business owner and her neighbor.
Moore links Maryland primary to Mamdani-backed wins; analysts disagree
Gov. Wes Moore says Maryland’s primary election showed voters rejected the status quo, but political analysts say the results reflect a more complicated picture.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
This week in science: Exoplanetary salt clouds, ancient families and laughter's origin
Hosts from NPR's science podcast Short Wave talk about an exoplanet with pink, salty clouds, the surprising social structure of ancient human relatives and the origins of laughter.
Participating in heavy-contact youth sports, dropping out of sports linked to acts of violence
Contrary to popular belief, simply playing organized youth sports does not reduce the likelihood of committing violence in one’s lifetime, and in some cases, may increase it, according to a new study.The study, published online recently in the Sociology of Sport Journal, found that while most survey respondents — including those who played y...
Check politics at the door? Not at many workplaces, researcher says
When people think of workplace segregation, they usually think of race or gender. Yet Americans are also sorted at work by something employers rarely measure: how they vote.
Falls Church Business News & Notes 6-25-2026 - Falls Church News-Press Online
Falls Church Business News & Notes Falls Church Business News & Notes Local Business Updates A full interactive roundup of chamber recognitions, business expansions, events, regional awards, and one correction. Expand All 8 total notes Includes full correction Links preserved Chamber Businesses Named Top Workplaces New Editions Consulting ranked #2 among small businesses. ⌄ New
UT Health San Antonio identifies the first potential probiotic treatment for lupus
Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, June 25, 2026 – Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, found a link between a bacterium in the gut microbiome, or ecosystem, and lupus, which could lead to more effective […]
MoCo real estate firm acquires Frederick business park
Minkoff Development Corp., a real estate firm headquartered in Germantown, has acquired Wedgewood North Business Park in Frederick.
Life Aboard the Langseth: A Q&A With Chief Science Officer Cody Bahlau
On Columbia’s global research vessel, the R/V Marcus G. Langseth, Bahlau serves as the key link between scientists, crewmembers and operations on shore.
Americans Are Not Buying White House’s Trump Health Claims
New polling shows what a majority of Americans really think of the explanations about 80-year-old Trump.
JD Sports Upgrades Listing to Broaden U.S. Investor Access
Shares of JD Sports in the U.S. now trade on the OTCQX exchange from the Pink Limited Market, broadening its access to deeper capital pools.
Databricks’ former AI chief thinks he can cut AI’s power bill by 1,000x
Un0 is an image-generation system tool that shows for the first time how the company's technology can replicate conventional AI systems.
19th Hole party zone brings entertainment, drinks, and live music to Wichita Open
The 19th Hole at Crestview Country Club has become one of the tournament’s signature attractions, offering live entertainment, local vendors, cocktails, games and a lively atmosphere throughout the four-day event.
How 12 ventures will improve health and food systems in Boston
Yes/Boston has announced its 12-member cohort through the UpLink Innovation Challenge to drive local innovation and transform food and health in Boston.
Entertainment this week: Paul Thorn, Hike for Hope and more
Friday, June 26 Annual Ian Casey Classic – Tahoe Donner Golf Course. Our most popular event of the year, a full field of 130+ golfers will team up in foursomes and hit the links to...
The Overlooked Reason ‘Destiny 2’ Is So Fantastically Fun Right Now
Destiny 2 is in an amazing state right now, which is unfortunately right at the end of the game. I think one thing deserves a good amount of credit.
Myles Garrett's Rise Could Fuel T.J. Watt's Next Steelers Surge
For years, T.J. Watt and Myles Garrett have been linked in one of the NFL's defining player rivalries. Now, with Garrett pulling ahead in recent seasons and Patrick Graham arriving in Pittsburgh, Watt has fresh reasons to respond. For much of their careers, Watt's production far outpaced Garrett's. That changed in 2023 when the Cleveland Browns hired Jim Schwartz as defensive coordinator and Garrett elevated his game to another level.