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Meccha Chameleon Fans Bring The Hide-And-Seek Game To Real Life
The painted prop hunt game has escaped the digital space and entered the real one
Amazon Is Awash With AI-Written Guideslop For Unfinished Games
Buy your novel-like, image-free, hallucinated guide to Alien: Isolation 2 today!
Leaked A20 Pro Image Hints at iPhone 18 Pro Performance Gains
An alleged image of the iPhone 18 Pro motherboard has leaked online, showing the A20 Pro chip will use a new packaging technology that should offer notable performance gains over the previous model. The leaked image, which has been shared by the accounts "WHYLAB" and "Ice Universe" on Weibo, appears to show the A20 Pro chip integrated into TSMC's new packaging architecture, known as Wafer-Level Multi-Chip Module (WMCM) technology.
How South Dakota schools are shifting to 'science of reading'
South Dakota is retraining teachers in the 'science of reading' to help students master foundational skills. Here’s how.
Danny White earns big bonus for Tennessee bowl, NCAA tournament toward $3.3M pay
Tennessee athletics director Danny White earned $577,500 in annual bonuses to push his total compensation past $3 million as one of the highest paid ADs in the country.
Rural Fosston moves forward in its quest to relinquish control of local hospital from Essentia Health
A northwestern Minnesota community is seeking to regain local control of its hospital, arguing Essentia Health has failed to meet local health care needs. A recent court ruling allows Fosston to take its case to arbitration.
Quality coffee, Ojibwe bonds build a business on the Fond du Lac Reservation in NE Minnesota
At a roadside kiosk on the reservation, Jackson Ripley and his family blend great coffee and Ojibwe culture together with a bit of magic. In the process, they’ve built new community ties, and they’re hoping to do more.
Notable Rutgers grads and former students
Some notable Rutgers alumni include James Gandolfini, Chris Christie, Eric LaGrand and more.
2027 NFL Draft Summer Scouting Report: DJ Lagway, QB, Baylor
Could a change of scenery help rebuild the draft hype of DJ Lagway? Check out his 2027 NFL Draft summer scouting report!
2027 NFL Draft Summer Report: Drew Mesetmaker, QB, Oklahoma State
Is Drew Mesetmaker the wild card in the 2027 NFL Draft? Read his summer scouting report to learn more.
Baker Mayfield Drops Clear Message on Kyler Murray
As Kyler Murray seeks a fresh start in Minnesota, former teammate Baker Mayfield defends the polarizing quarterback, predicting a dominant resurgence fueled by a much-needed change of scenery.
These Were the Biggest Losers of Vikings Offseason
The Minnesota Vikings had some vivid “winners” this offseason, including center Blake Brandel, who is on tap to start at […]
Rory McIlroy
The Travelers Championship is the final signature event of the 2026 PGA Tour season, with a total purse of $20 million.
Laredo Public Health issues summer food, pool safety reminders
Laredo Public Health is reminding residents of food and pool safety steps as warmer weather increases the risk of foodborne illness.
Justin Jefferson lands inside top 10 of CBS Sports Top 100 list
Justin Jefferson represented the Vikings near the top of Pete Prisco’s CBS Sports Top 100 players list, landing at No. 8 overall.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
I Put Apple CarPlay In My Wife's 2006 Toyota 4Runner And I'm Never Looking Back
Despite its 300,000 miles we're not getting rid of the 4Runner anytime soon, so it was worth making a small investment to bring its infotainment into the 2020s.
Suns trade Grayson Allen, Royce O'Neale for Miles Bridges
The Suns have agreed to trade two key rotation players and a 2033 first-round pick for Hornets forward Miles Bridges and future draft capital.
AI As Conscious As That Toy Bird Is Thirsty
OpenAI and the like are using our fantasies about technology to bilk investors, if we want to protect the public we need to establish the difference consciousness and something mimicking it
Sanford Health to highlight best practices for AI adoption at national leadership conference
Sanford Health’s Dr. David Newman will speak at two HIMSS AI conferences in Boston this week, discussing AI adoption, governance and clinical workflows.
Rabid bat confirmed in Shawano County, health officials urge caution
Wausau Pilot & Review SHAWANO — Health officials are urging residents to use caution around bats and other wild animals after a bat in Shawano County
Xbox Pre-Order Sales For GTA 6 Break Records Despite PS5 Blitz
Microsoft says Xbox pre-order sales have broken records
Sarasota Business Awards honor innovation, entrepreneurship and the American spirit
The Greater Sarasota Chamber of Commerce recognized businesses in the community across 10 categories.
Linux 7.3 To Introduce DRM "Color Format" Property With AMD GPU Driver Support
While the Linux 7.2 kernel merge window is only ending later today to cap off the feature work on this next version of the Linux kernel, already for the Linux 7.3 kernel cycle later in the year there is one notable feature on the way: the DRM color format property is being introduced and being first supported by the AMDGPU kernel graphics driver.
Important Penn State prospect makes notable physical transformation
Penn State star Max Granville’s career has been stunted by injuries so far, but his body transformation is sure to excite fans.
Famitsu review scores - June 28, 2026 - Star Fox for Nintendo Switch 2 and more
The latest Famitsu review scores for the week of June 28, 2026 are as follows: Star Fox – 8/9/9/8 The Last Salvage Squad – 8/7/8/7 Mousebusters – 7/8/8/6 Note that for each review, four editors gave out scores. The final total in the Famitsu review is there for out of a total of 40 points. For previous Famitsu scores, check...
Pokémon GO Events This Week: June 29
Pokémon GO’s June 29 – July 5 week sees us enter the second month of the season of Forever Forward! We end June and kick off July with 10th Anniversary celebrations and Sobble Community Day! Plus the weekly rotating Raid Hours, Spotlight Hour, Dynamax Battles and Mega Raids. ⭐Highlights Raid Boss Change (July 1): Articuno, Zapdos, Moltres and […]
Hunter Goodman smashes three home runs vs. Twins
Colorado Rockies designated hitter Hunter Goodman hit three long home runs against the Minnesota Twins on Saturday. Goodman crushed two no-doubters — solo shots in the first and third innings — in his first two at-bats against Twins starter Mike Paredes. Then, after grounding out in the fifth, Goodman came up with two runners on base and the Rockies leading 3-2 in the seventh.
Black Hills Renaissance Fair draws crowds for weekend of medieval entertainment
The kickoff of the Renaissance Festival started on Saturday
Timberwolves Re-Sign Jaylen Clark to Three-Year Contract
Minnesota brings back its defensive specialist on a team-friendly deal during a summer full of roster turnover.
As free agency nears, the Wild have business to attend to beyond Dylan Larkin
Larkin is the player the Wild want, but they will also need to re-sign or replace players like Mats Zuccarello and Vladimir Tarasenko.
3 million Americans have dropped Obamacare health coverage over past year, after Republicans let federal subsidies expire
KFF expects the total number of people in the government healthcare program to continue to decline throughout the year, potentially to a low of about 17.5 million from 19.2 million now.
Is Tencent Music Entertainment Group (TME) A Bargain Following Its Sharp Pullback?
Tencent Music Entertainment Group (TME) has drawn fresh attention after recent trading left the stock down about 9% over the past month and about 11% over the past 3 months, which has sharpened the focus on its current valuation. See our latest analysis for Tencent Music Entertainment Group. At a recent share price of $8.39, Tencent Music Entertainment Group has posted a year to date share price decline of about 53% and a 1 year total shareholder return decline of about 55%. However, the 3...
Flyers hope to hit on another fifth-rounder from Minnesota high school level
The Flyers have had some success with fifth-rounders from the Minnesota high school level. They’ll hope Kent Sauer adds to it.
Strike out the Stigma initiative partners with teams for veteran mental health
A North Dakota insurance company is stepping up to the plate to promote mental health.
Burcum: Sanford Health got what it wanted. Now comes the moment of truth.
From columnist Jill Burcum: The South Dakota health system has spent a decade trying to crack the Twin Cities health care market. With the North Memorial deal, it now has a chance to prove itself.
A Clover Health Director Sold Over 67,000 Company Shares. Here's a Closer Look at the Transaction.
This healthcare technology firm, focused on Medicare Advantage plans, reported a notable insider sale amid muted stock performance.
NHL Rumors: 3 Red Wings Who Could Be Traded Next
The Detroit Red Wings made a notable trade on Friday, as they traded top goalie prospect Sebastian Cossa to the Utah Mammoth in exchange for the 23rd overall pick of the NHL Entry Draft. The Red Wings then used that pick to select forward J.P. Hurlbert.Seeing Cossa get traded by the Red Wings is not […] The post NHL Rumors: 3 Red Wings Who Could Be Traded Next appeared first on HEAVY.
Apple A20 Pro motherboard leak hints at notable memory and packaging upgrades
A leaked package layout of Apple's A20 Pro hints at several notable upgrades for the iPhone 18 Pro series. The next-gen SoC is said to feature a wider 96-bit memory interface, a redesigned packaging approach for improved thermals, and a larger Neural Processing Unit (NPU).
Could the Vikings eventually be forced to trade Justin Jefferson?
Is there a scenario where the Minnesota Vikings are forced to trade Justin Jefferson?
Testing gives science-based data for Fairmont lakes
FAIRMONT— A partnership between the city of Fairmont and Minnesota State University-Mankato will result in comprehensive scientific data on the Fairmont Chain of Lakes. The $25,000 contract started on April 1 and will go through Dec. 31 of this year. Fairmont’s Water Resources Coordinator, Hannah Neusch, acknowledged that while the water treatment plant in Fairmont […]
State Street Eating House owner wins women-owned business award at Sarasota ceremony
Owner says she was unprepared for the recognition at the Frank G. Berlin, Sr. Sarasota Business Awards.
‘A total fairytale’: Former Watergate prosecutor reacts to Vance’s comments on the scandal
Politics Unusual: Co-chairs of NYC-DSA, Rep. Malliotakis
In this episode of Politics Unusual, FOX 5 NY's political reporter Morgan McKay sits down with the co-chairs of New York City's Democratic Socialists of America to discuss their success on primary night. Also, a conversation with Rep. Nicole Malliotakis about the rise of democratic socialism and the direction the Democratic Party could take in the coming years.
House Republican reacts to changing politics under Trump
Republican Rep. Dusty Johnson spoke to NBC News' Garrett Haake about his recent loss in the primary to become the governor of South Dakota, and how he feels about the current political environment under President Trump.
Registration open for 2026 Behavioral Health & Children and Family Services Conference | Health and Human Services North Dakota
Registration is now open for the sixth annual Behavioral Health & Children and Family Services Conference, scheduled for Sept. 14-17 at the Bismarck Event Center and online through a livestream option.The main conference will take place Sept. 15-17, with optional pre- and post-conference sessions offered Sept. 14 and Sept. 17.More than 1,400 in-person attendees and hundreds of virtual participants are expected to take part in keynote presentations, breakout sessions and networking opportunities focused on behavioral health, child welfare, suicide prevention and youth development.
Essentia again ranks among Minnesota's best for quality care
Minnesota Community Measurement (MNCM) — a statewide resource providing timely, comparable information on healthcare quality, costs and equity — once again ranks Essentia Health as a quality leader in its annual Health Care Quality Report.
PlayStation Is Deleting Terminator 2 And 550 Other Movies
Movies like Rambo: First Blood, Bridget Jones' Diary and The Deer Hunter are all being unceremoniously removed
PlayStation hardware sales fall to their lowest May total since 2000
Price rises hit Sony's console sales, but 007 First Light and Switch 2 help US game spending to grow 3%
Epic's Tim Sweeney Keeps Inventing Solutions To Problems That Are Already Solved
Quick, someone tell him what Discord is
2027 iPhone 18 and iPhone 18e to Get 9GB RAM and A20 Chip
The lower-end iPhone 18 models set to launch in spring 2027 will feature 9GB DRAM, up from 8GB, according to Apple analyst Ming-Chi Kuo. Kuo says the A20 chip Apple plans to use for the devices will have 1.5GB x 6 dies for a total of 9GB RAM, instead of 2GB x 4 dies as the current lower-end iPhone 17 models use. By lower-end iPhones, Kuo is likely referencing the iPhone 18 and the iPhone 18e, both of which are rumored to be coming around March or April of 2027.
Falco In Star Fox Is Every Toxic DPS You've Ever Played With
‘I could use some of that teamwork!’
Last Chance To Fix Destiny 2 Delayed After Bungie Lays Off Devs
Bungie is running out of chances to set things right in its sci-fi MMO before it's left behind for good
Dragon's Dogma 2: Dark Arisen: What We Learned In Capcom's Showcase
Kento Kinoshita, Dragon's Dogma: Dark Arisen's original director, is returning for Dragon's Dogma 2: Dark Arisen
Where QBs landed in Prisco's Top 100 NFL players of 2026, plus two notable snubs
Not only did Myles Garrett dethrone Patrick Mahomes as the No. 1 overall player, but the Chiefs star fell behind three other QBs in Prisco's 2026 list
How Brad Pitt appears in “Jackass: Best and Last”: 'It was wild,' says Steve-O
The "Inglourious Basterds" actor shows up in the latest "Jackass" movie via archival footage from 2001.
Is AMC Entertainment Holdings (AMC) Undervalued Or Is Its Recent Rally Already Priced In?
AMC Entertainment Holdings (AMC) is under renewed scrutiny as investors weigh its recent share price swings and ongoing losses against reported revenue of $5,031.8 million and a market value of about $1.5 billion. See our latest analysis for AMC Entertainment Holdings. At a share price of $1.89, AMC Entertainment Holdings has seen sharp swings, with a 7 day share price return down 33.22% but a 90 day share price return up 99.33%. The 1 year total shareholder return is down 37.42%, indicating...
North Dakota State Fair 2026: Food, Entertainment, Pride of Dakota Festival, Contests, and More
MINOT, ND (KXNET) — There are now three weeks until this year’s North Dakota State Fair kicks off, and the Fair is including America’s 250th birthday. The fair is an official partner of…
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Introducing: Breguet Celebrates the 225th Anniversary of the Tourbillon with Four New Releases, And the Return of a Collector Favorite (Live Pics)
A revived and revised version of the Roth-designed caliber 558.1 movement (significantly improved) headlines four watches to celebrate the patent date of one of Abraham-Louis Breguet's most notable achievements.
Real Madrid’s summer spending spree creates unexpected Champions League problem
Real Madrid have been one of the busiest clubs in the transfer market, but their impressive recruitment spree may have created a technical issue.Notably, Jose Mourinho has already welcomed four new si...
Children's Minnesota doctor warns of Benadryl challenge dangers
Lionel Richie postpones concert at United Center in Chicago following health scare at Minnesota show
Lionel Richie has postponed his concert this week at the United Center in Chicago following his health scare at during his first performance in a tour with Earth, Wind and Fire.
Valve Deletes 4K 60FPS Claim From Steam Page After Reviews
Some have struggled to hit consistently high framerates on the new hardware
40+ Steam Summer Sale Games That Are Just $10 Or Less
You can get Dead Island 2, Devil May Cry 5, The Witcher 3, and Ghostwire Tokyo for just $20 right now on Steam
Palmetto Sports Daily: Hornets star Lamelo Ball traded to Minnesota, Lamont Paris talks NIL negotiations
On the latest episode of Palmetto Sports Daily, the crew discusses the blockbuster trade sending LaMelo Ball to the Minnesota Timberwolves, and SC men’s basketball coach Lamont Paris discusses NIL contracts.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
NASA Selects Rocket Lab to Launch Sun, Earth Science Missions
NASA has selected Rocket Lab to provide the launch service for both the agency’s PolSIR (Polarized Submillimeter Ice-cloud Radiometer) and Total and Spectral Solar Irradiance Sensor-2 (TSIS-2) missions.
Kurt Zellers out in shakeup at Minnesota Business Partnership
The lobbying group replaced with co-interim CEOs, a former state director for Amy Klobuchar and a Republican aide.
Falls Church Business News & Notes 6-25-2026 - Falls Church News-Press Online
Falls Church Business News & Notes Falls Church Business News & Notes Local Business Updates A full interactive roundup of chamber recognitions, business expansions, events, regional awards, and one correction. Expand All 8 total notes Includes full correction Links preserved Chamber Businesses Named Top Workplaces New Editions Consulting ranked #2 among small businesses. ⌄ New
Consumer Discretionary Stocks Drawing Institutional Rotation Into Live Entertainment Leaders
With the Federal Reserve hinting at a pause in rate hikes, stubborn inflation still in the background, and several large companies surprising on earnings, consumer discretionary stocks are back in focus for investors weighing risk and opportunity. This article looks at how that mix of easier policy signals, solid corporate reports, and ongoing geopolitical and supply chain issues could affect larger U.S. consumer-focused companies. It will walk through 3 stocks from a curated screener that...
South Dakota mayoral candidates separated by just two votes in shockingly close race, recount expected
The Sioux Falls mayoral runoff contest shockingly resulted in just a two-vote margin separating the candidates out of more than 36,000 ballots cast.
Kurt Zellers departs as Minnesota Business Partnership CEO in latest business lobby shuffle
A sudden departure of Kurt Zellers at the Minnesota Business Partnership is just one of the changes ahead for business advocacy groups in the state.
Star Fox Players Are Up To Debauchery With Its VTuber Avatars
Who could have foreseen this?
'Avengers: Endgame' rerelease confirms new title, footage, and end tag
'Avengers: Endgame' rerelease gets a new title and confirms fresh footage and a special end tag.
Survey finds Roy Cooper continues to hold double digit lead in N.C. Senate race
A new survey finds former North Carolina governor Roy Cooper leading former Republican National Committee Chair Michael Whatley by double digits in the pivotal Senate race in November.
Longtime Entertainment Industry Lawyer Joins Royalties Retriever SoundExchange
Michele Page, formerly of Peloton Interactive, arrives at a pivotal time for the nonprofit reeling from a court ruling that may impair its ability to sue on behalf of artists.
'Unflappable' Justin Wrobleski Becoming 'The Shark' In Dodgers' Rotation
Justin Wrobleski created his own model to chart his development. Here's how it's taken him from fringe starter to potential All-Star.
Supreme Court allows Trump administration to end legal protections for Haitians and Syrians
The 6-3 decision overturns lower court orders and allows the Department of Homeland Security to swiftly end temporary protected status, a program that protects a total of 1.3 million people from 17 countries.
LaMelo Ball trade grades: The Hornets' logic makes sense, but what is Minnesota's thought process?
LaMelo Ball traded to Minnesota Timberwolves: Hornets ship out All-Star point guard in stunning deal
Charlotte will receive Naz Reid and a swath of future picks in the trade
Trump to meet House speaker in attempt to break legislative gridlock
Trump suddenly scrapped the signing of a pivotal bipartisan housing bill yesterday, demanding the Senate pass his voter ID bill
Lionel Richie falls sick, abruptly ends All Night Long tour opener
Lionel Richie abruptly cut his Minnesota concert tour opener short after "feeling dizzy" on stage.
Ensuring health for Special Olympics athletes
University of Minnesota healthcare students across many disciplines are helping to provide health screenings for athletes competing in the 2026 Special Olympics USA Games.
Grading every move from the Steelers’ 2026 offseason
Did the Steelers hit the mark in one of their most pivotal offseasons in recent memory?
Who's No. 1 in Morris/Sussex high school sports?
The Daily Record and New Jersey Herald totaled up each high school's 2025-26 success to determine the Top 10 athletic programs.
Griffin Jax Leads Rays Past Royals 5-3 as Tampa Bay Snaps Two-Game Skid
The Rays snapped their two-game skid with a 5-3 win over the Royals as Griffin Jax continued to shine in the rotation. Tampa Bay also got key contributions from Jonathan Aranda, Yandy Díaz, and Jonny DeLuca, while Bryan Baker locked down his 20th save of the season.
Dodgers Overcome Dalton Rushing’s Mental Struggles to Sweep Twins
The Los Angeles Dodgers swept the Minnesota Twins on Wednesday despite some struggles by catcher Dalton Rushing.
Travis Kelce's Journey: From Rookie to NFL Superstar and His Life with Taylor Swift
Travis Kelce is entering his 14th season in the NFL, all of which have been with the Kansas City Chiefs. After being selected No. 63 overall in the third round of the 2013 NFL Draft by Kansas City, Kelce played only a single special teams snap as a rookie, in a Week 2 game against the Dallas Cowboys. The seven-time All-Pro has set all-time marks for the Chiefs, such as surpassing Hall of Fame tight end Tony Gonzalez's 10,940 career receiving yards (13,002) and passing three-time first-team All-Pro Priest Holmes' 83 total career touchdowns (85).
Health insurers propose high rate hikes for 2027 Minnesota plans
To find out why and how much it'll burden customers, policy analyst Matt McGough with KFF Health News joined Morning Edition Wednesday.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
What does CBS Sports think is the best case scenario for the Vikings?
The Vikings season could go one of two ways, what does CBS Sports think is the good way?
South Dakota business bankruptcies down, but closures and farm reorgs up
While post-pandemic Chapter 11 business bankruptcy filings in South Dakota are down, the number of business closures and Chapter 12 filings, common with farmers, have risen.
Overwatch Fans Revolt Over New Skins That Cost Too Damn Much
The new ‘Ultra’ skins include visual and audio effects, but is that enough?
Uh, Rockstar, Please Fix This Massive GTA 6 Lore Mistake
Here's 350 words or so about two revolvers featured in a single marketing image
50 Cent Diddy documentary alleges blame for Biggie, Tupac deaths
50 Cent's new documentary chronicling the rise and fall of Sean "Diddy" Combs hit Netflix Tuesday, complete with bombshell revelations, never-before-seen footage and insider interviews.
455 people including doctors charged in historic $6.5B health care schemes
Over 450 people, including 90 medical professionals, are facing charges in global health care fraud schemes totaling $6.5 billion.
New GTA 6 Gameplay Footage Shows Incredible Vice City Beach Details
[responsivevoice_button] Rockstar Games have just released a new look at GTA 6. Alongside the GTA 6 pre-order info such as price, 60+ screenshots and more, Rockstar Games have provided fans with a…