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Opinion | How Roy Cohn Shaped Trump
A new book reveals how the lawyer’s legacy lives on decades after his death.
How A.I. Tokens Work
As large language models become more advanced, they use ever more resources. Who will foot the bill?
Will Trump’s Midterm Convention Help or Hurt Republicans? 5 Things to Watch.
At an unusual gathering in Dallas, some of the party’s top candidates will be forced to decide just how tightly to tether themselves to an unpopular president.
Film and TV Portrayals of A.I. Go Beyond Science Fiction
Plots involving some kind of artificial intelligence are even part of soap operas. Here’s how they’ve evolved over the decades.
Nonprofits Are Helping Musicians Pay for Insurance in Austin, Texas, and Beyond
A nonprofit and a local public health agency are subsidizing marketplace health insurance for Austin music artists, even as shifting marketplace conditions make the program a more expensive proposition. It’s becoming a model for other cities and sectors.
A rare thing in American politics may happen in Rhode Island on Wednesday
Gov. Dan McKee barely beat Helena Foulkes in 2022. For Wednesday’s rematch, the former CVS executive has outraised him and appears well positioned to win.
Wellington Management Group LLP Acquires Shares of 406,352 PENN Entertainment, Inc. $PENN
Wellington Management Group LLP bought a new position in shares of PENN Entertainment, Inc. (NASDAQ:PENN - Free Report) in the 2nd quarter, according to its most recent 13F filing with the Securities & Exchange Commission. The institutional investor bought 406,352 shares of the company's stock
Leeds United handed positive omen vs Chelsea with announcement
Daniel Farke celebrating at Leeds United towards a Chelsea badge
96,800 Shares in Caesars Entertainment, Inc. $CZR Acquired by Governors Lane LP
Governors Lane LP acquired a new position in Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) during the second quarter, according to the company in its most recent filing with the Securities & Exchange Commission. The institutional investor acquired 96,800 shares of the company's stock,
Why does early treatment matter for psychotic episodes?
Early treatment for psychosis can improve recovery and challenge the idea that mental illness means a lifetime of suffering.
What ‘right’ and ‘left’ mean in Israel today
In Israel, the left-right divide is shaped less by economics than by positions on Palestinian statehood and occupation.
Belgium battle could be a blessing
It is a new chapter for Aston Villa and, against Club Brugge, they turned the page. A first win of the season, albeit more nervy than anticipated, lit the spark for Unai Emery's side. The visitors were in a commanding and deserved position at half-time, John McGinn's opener making him the club's all-time record European goalscorer with 12.
Lindsay Clancy and postpartum psychosis
The trial around Lindsay Clancy may be over for now, but it still leaves us with questions. On today’s episode, we talk to psychiatrists and patients to answer them: What is postpartum psychosis, exactly? Why don’t we know more about it? And what can you do if you are worried about a postpartum loved one?Interested in more stories on mental health? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Stacy’s Streamers: Four Players to Start in Week 1
Stacy Perez highlights one player at each position who is worth streaming in Week 1.
From moving people to managing them
Transportation policy used to have a fairly uncomplicated purpose: move people safely, efficiently and reliably. Build roads where people drive. Maintain bridges before they fail. Add capacity where growth overwhelms the system. Provide transit where it makes sense. Infrastructure was supposed to accommodate human behavior. Colorado increasingly prefers the opposite arrangement. Today, transportation policy is […]
Curiosity Blog, Sols 4995-5001: 5,000 (Martian) Days on Mars
Written by William Farrand, Senior Research Scientist, Space Science Institute
Amazon Cargo Jet Pilots Appeared to Try Aborting Landing, N.T.S.B. Investigation Indicates
The sequence of events detailed by National Transportation Safety Board investigators showed that the pilots lost crucial seconds before the plane ran off the runway in Miami.
Houston’s Newfound Point Guard Depth
The Houston Rockets have fixed their depth issue at the point guard position. Here is why
Burning Questions: Indiana Football Preparing For Week 2 Against Howard
Indiana smacked North Texas around in week one and it's supposed to be even worse this week as the Hoosiers host Howard.
Trump’s Ability to Channel Voter Concerns Is Tested as Republicans Gather in Dallas
As Republicans face down tough midterm elections, President Trump has appeared out of step with the party on Iran, the economy and other issues.
Bruins’s Casey Mittelstadt Gets Honest About 1st Year In Boston
It won’t be long now before the Boston Bruins gather for Training Camp in preparation for the 2026-27 NHL Season, and they’ll be out to prove that they’re better than losing in the opening round of the Stanley Cup Playoffs as they did earlier this spring.One of the key forwards for the Bruins is Casey […] The post Bruins’s Casey Mittelstadt Gets Honest About 1st Year In Boston appeared first on HEAVY.
Trump-Backed Auto Executive Wins House Primary in New Hampshire
Anthony DiLorenzo, an automotive executive who ran with the president’s endorsement, will be the Republican nominee in the First Congressional District.
John E. Sununu Wins Republican Senate Primary in New Hampshire
The general election race to replace Jeanne Shaheen, a Democrat, could help determine control of the U.S. Senate.
Chris Pappas Defeats Progressive Challenger in New Hampshire Senate Primary
Mr. Pappas, a moderate Democrat who has served four terms in the House, will face former Senator John E. Sununu, the Republican nominee, in November.
Mike Tomlin Reveals ‘Best’ Steelers Team he Coached
Mike Tomlin is making the media rounds as he begins his new career in broadcast. This comes after 19 seasons as head coach of the Pittsburgh Steelers. Tomlin won a Super Bowl early in his tenure and was known for never having a losing season in Pittsburgh. However, fans began to clamor for change in […] The post Mike Tomlin Reveals ‘Best’ Steelers Team he Coached appeared first on HEAVY.
Letting Myles Turner Walk Was Best Decision Pacers Ever Made
Losing Myles Turner looked tough at first, but in the end, it was one of the best moves by the Indiana Pacers.
Carmignac Gestion Buys Shares of 100,508 Caesars Entertainment, Inc. $CZR
Carmignac Gestion bought a new position in shares of Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) during the 2nd quarter, according to the company in its most recent 13F filing with the Securities & Exchange Commission. The institutional investor bought 100,508 shares of the company'
Project Fibonacci to celebrate 10 years with charity gala
The Project Fibonacci Foundation will celebrate a decade of curiosity, innovation, opportunity, and community impact with Tap Into STEAM: The Golden 10 on Sunday, September 13, at the Irish Cultural Center in Utica, according to organizers.
Let’s Grade That Win Over Coastal Carolina by Position Group
Hope everybody enjoyed the holiday the right way. Grill going, family around, maybe a cold drink in your hand, and a win in the books to talk about while you do it. That’s the good life. Before we get too deep into the cookout, let’s talk about what we saw Saturday, because there’s a lot […]
Central Health to vote on proposed property tax increase for Travis County
Your property taxes could go up again next year. Central Health, which is the hospital district for Travis County, is proposing an increase to provide mental health services to those in crisis.
Dueling Court Rulings Leave Missouri’s Congressional Races in Chaos
After losing in two courts and winning in another, Missouri officials said they planned to forge ahead with using a congressional map that was redrawn to benefit Republicans.
Opposing court orders upend Missouri midterms just weeks before Election Day
(CNN) — Back-to-back court orders on Tuesday injected chaos into Missouri’s plans for this year’s midterms, with state officials and a group opposed to a GOP-friendly congressional map racing into
Video: Opinion | The ‘Hyperpoliticization’ of American Politics
Anton Jäger argues on “The Ezra Klein Show” that we’re in a distinct era of “hyperpolitics” — where politics feels volatile, ubiquitous and intense, but is not securely attached to institutions and structures.
Southern Union names Pike dean of health sciences
CONTRIBUTED BY SUSCC OPELIKA — Southern Union State Community College has named Dr. Richard Pike as dean of health sciences. Pike assumed the position Sept. 1 following the retirement of Dean Rhonda Davis. A graduate of Southern Union, Pike earned an associate in science degree and his emergency medical technician certification from the college. He […]
Politics News Site NOTUS Rebrands as The Washington Sun
A trademark dispute scuttled its plans to relaunch as The Washington Star, so the site chose a different name.
William O'Dowd IV Discloses Investment at Dolphin Entertainment with 19.0% Stake
William O'Dowd IV, the CEO of Dolphin Entertainment, Inc., reported beneficial ownership of 19.0% of the company's common stock. He filed a Schedule 13D on Sep. 08, 2026, after an earlier note exchange and a pre-set buying plan in 2025. The position includes common shares and the right to convert c…
Porto vs Manchester City Match: Champions League Live Updates
Porto hosts Manchester City at the Estádio do Dragão on Tuesday, September 8, in the opening round of the 2026-27 UEFA Champions League phase. Both teams enter the European opener in strong domestic form and will be looking to start their Champions League campaigns with a positive result. Kickoff is scheduled for 8 p.m. BST, […] The post Porto vs Manchester City Match: Champions League Live Updates appeared first on HEAVY.
NASCAR CEO on future business growth: All about partnerships
Steve O’Donnell, NASCAR CEO, and Matt Hong, USA Sports president, join 'Closing Bell' to discuss the business of NASCAR, how to keep business momentum and much more.
Joe Biden shares health update after prostate cancer diagnosis while issuing warning to others
Joe Biden revealed his radiation treatment from last fall "worked as intended" as he urged men to discuss prostate cancer screening with their doctors.
UCF Graded Top-10 Performer in CFB Following Week One
After a 73-6 blowout fueled by Duke Watson’s explosive debut, the Knights carry elite Pro Football Focus grades into a high-stakes road test against Pittsburgh’s high-powered offense.
Staff Takeaways: Everton 2-2 Manchester United
Staff Takeaways from Manchester United’s 2-2 outing away to Everton on Sunday Colin: Everything but the finish Manchester United could not finish the job on Sunday. When attacking, they couldn’t finish moves and get the ball to a player in dangerous positions. When defending a lead, they couldn’t assert control to calm the game down […]
AT&T Business Expands Work with Amazon Leo for Resilient Connectivity
AT&T Business has furthered its agreement with Amazon’s Amazon Leo constellation to offer “converged connectivity solutions” integrating satellite
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Funding cuts are forcing dozens of health clinics in Sudan to close, aid groups warn
CAIRO (AP) — An additional three dozen health facilities serving more than 400,000 people in Sudan are closing this year due to global aid cuts, worsening a dire humanitarian situation in a country torn by more than three years of war, aid groups said Tuesday.
Business Aviation Insight. Reassessing Large-Cabin Value After the Falcon 900LX’s Final Delivery Year
Challenger 650 – Photo Credit: Bombardier The Falcon 900LX and Challenger 650 sit at opposite ends of a large-cabin segment that, on 2026 data, now spans nearly $19 million in …
Trump Administration Asks Supreme Court to Allow Voter-Screening Tool
Voting rights organizations had challenged a Trump administration overhaul of a government database, arguing it could be used to disenfranchise eligible voters.
Drug developed for lung disease may slow biological aging in surprising ‘bonus’
Rentosertib, an AI-discovered drug for idiopathic pulmonary fibrosis, made patients appear three to four years biologically younger in a clinical trial.
Doctors Without Borders warns that funding cuts are forcing health clinics to close
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts. This worsens an already dire humanitarian situation in a country torn by more than three years of war.
Funding cuts are forcing dozens of health clinics in Sudan to close, aid groups warn
Aid groups say three dozen health facilities in Sudan are closing this year due to global aid cuts
Endometriosis can go undiagnosed for years. Here's what to know
Endometriosis afflicts 1 in 10 women worldwide, but diagnosing the painful disease is a challenge. New tests being used in other countries could help.
Rabid skunk confirmed in Pickens County, health officials say
DPH announced Tuesday that a skunk found in the Upstate has tested positive for rabies.
Endometriosis may increase type 2 diabetes risk
Researchers found that some women with endometriosis may have increased risk of developing type 2 diabetes.
After Causing Delays for 9/11 Health Claims, Social Security Pledges to Do Its Job
Lawyers say the Social Security Administration has for months not provided basic data to complete compensation claims for those sick and dying after exposure to debris from the Sept. 11 attacks.
Scientists Are Still Trying To Understand How the Moon Formed
The Earth and the Moon have nearly identical isotopic compositions, and the Giant Impact Hypothesis strives to explain this. New research into the ancient impact shows how the temperature of both worlds, and how it affects the strength of the materials involved in the collision, shaped the outcome, including the isotopic compositions.
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Pritzker, Eyeing 2028, to Help Midterm Democrats With a $20 Million Group
JB Pritzker, the billionaire governor of Illinois, is continuing to expand his national footprint, this time by using a new group to target Republicans in battleground races.
Youth with CF on approved treatment still face mental health issues
Youth with cystic fibrosis continue to experience mental and behavioral health concerns despite treatment with Trikafta, according to a study.
Devers Records Giants First 35/35 Season Since 2002
Rafael Devers joins Jeff Kent in the San Francisco Giants franchise record books, leveraging an explosive September power surge to make up for the team's horrific season.
OpenAI Says It Has Cracked One of Math’s ‘Millennium Problems’
The company’s announcement is the most dramatic sign yet that artificial intelligence is fundamentally transforming the field of higher mathematics.
Years of Dismissed Pain, One Life-Changing Diagnosis
Bronx, NY – For 15 years, Jennifer Grant endured pelvic pain, severe nausea, and fainting episodes that no doctor could fully explain or treat. Dismissed
Paxton Aide Turned Whistle-Blower Appears in Ad Endorsing His Rival, Talarico
David Maxwell was among the staffers in the Texas attorney general’s office who accused Ken Paxton of abusing the power of his office, allegations that led to his impeachment. Mr. Paxton was acquitted.
‘Democrats Are Behind’: PAC Wants Party to Catch Up on A.I.
The group is starting with more than $10 million and says it intends to support midterm House candidates in swing states.
Jalen Duren contract talks take a positive turn
Jalen Duren and the Detroit Pistons remain without a deal, but new reporting suggests the contract gap may be narrowing.
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Sunderland 'deserved more' at Brentford
Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.
New Hampshire voters pick midterm nominees as Sen. Shaheen's exit sparks scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the 424-seat state Legislature on Tuesday, and incumbents aren’t the only familiar names on the ballot.
Star Stable Entertainment reduces workforce by 20% to secure long-term future of its multiplayer horse adventure RPG
Interim CEO says by "reducing operating costs and refocusing resources," Star Stable will be in the "best possible position to adapt and grow"
He lost $180K in retirement savings, now drives Uber and Lyft at 58
Bill Lewis, a former Wall Street broker, now drives for Uber and Lyft after losing his retirement savings in a failed franchise venture.
California’s political hopefuls remain silent on state’s job losses, unemployment
Dan Walters Commentary: The aspirants for those positions are making all sorts of promises to win voters’ approval. But few, if any, have mentioned a slow-motion menace affecting a fundamental
Jaclyn Smith says ‘Charlie’s Angels’ costar Tanya Roberts asked for threesome
‘Charlie’s Angels’ star Jaclyn Smith said costar Tanya Roberts once propositioned her for a threesome, adding that there was an ‘honesty about her sexuality.’
Sinclair's Criminally Obsessed to Present "Maternal Mental Health: How the Lindsay Clancy Trial Could Change Treatment" National Town Hall to Air on September 9
BALTIMORE – September 8, 2026 – Sinclair today announced a national town hall examining maternal mental health and the questions surrounding diagnosis, treatment and intervention that have been brought into focus by the Lindsay Clancy trial. Maternal Mental Health: How the Lindsay Clancy Trial Could Change Treatment will stream September 9 across Sinclair’s television station...
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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