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Scientists Discover the Earliest Evidence of Drug Use in Really Old Teeth
A hunter-gatherer who lived in Indonesia as early as 25,000 years ago may have regularly sucked on betel nuts to release their psychoactive properties.
Skip iPhone Duo and Slap $300 Off Galaxy Z Fold 8
It might be iPhone Duo day, but Samsung still has two excellent new foldables it doesn’t want you to forget about. Both the Galaxy Z Fold 8 Ultra and Galaxy Z Fold 8 are discounted heavily with no trade-in required. Instead of being an iPhone Duo beta tester, you can go with the best foldables...
Flutter Entertainment (FLUT) Faces A Valuation Test As Prediction Markets Draw NFL Attention
Flutter Entertainment (NYSE:FLUT) is stepping into the new NFL season with a fresh source of attention, as prediction markets attract industry focus and are discussed as potential rivals to traditional sports betting volumes. That renewed interest in prediction markets is arriving at a fragile moment for Flutter Entertainment’s share price. The stock trades at US$100.70 after a 7 day share price return of 3.81% and a 30 day share price return of 6.29%. However, it sits well below earlier...
Business alumni board builds momentum for future engagement
The inaugural Business Titans Alumni Board Summer Retreat brought alumni together for a collaborative and productive day on July 24 focused on shaping the new advisory board, strengthening connections and helping define the future of alumni engagement at the Cal State Fullerton College of Business and Economics. During the retreat, board members discussed priorities and identified […]
Veterans' mental health challenges
For many veterans, coming home does not mean leaving the impact of military service behind. As we approach the 25th anniversary of 9/11, it is important to recognize the mental health struggles many veterans face—often without treatment. Rawle Andrews jr., executive director of the American Psychiatric Association Foundation, discusses this with Good Day Austin.
C. diff coordinates threat response to survive in gut
Researchers at Vanderbilt Health have discovered a unique system C. diff uses to simultaneously sense and respond to two different threats.
ICYMI—Hagerty Joins Varney & Co. on Fox Business to Discuss Tariffs on Israel, Affordability
WASHINGTON—Today, United States Senator Bill Hagerty, (R-TN), a member of the Senate Foreign Relations, Appropriations, and Banking Committees, joined Varney & Co. on Fox Business to discuss the foreign trade restrictions on Israel and affordability ahead of the midterm election. *Click the photo above or here to watch* Partial Transcript Hagerty on foreign trade restrictions on Israel: I’m disappointed, […]
Paleontologists discover first adult 'T. rex' footpath
The Cretaceous dinosaur moseyed with a 13-foot-stride.
Mike Tomlin not closing door on NFL coaching return
Mike Tomlin isn’t closing the door on returning to the NFL, which means Mike Tomlin will be the center of coaching rumors until he either returns to the NFL or closes the door. Tomlin joined Cris and Jac Collinsworth on Pro Football Focus to preview the NFL season and discuss his transition to media as…
'I have grown up quite differently'
At 22-years-old, Mohamed-Ali Cho has had quite the journey to the Premier League. The young forward has already played senior football in Ligue 1, La Liga and now the top flight of English football is in his sights. After joining the Humberside-based club this summer for an undisclosed fee from Nice, the France under-21s international made his first start under boss Sergej Jakirovic in the 1-0 loss to Sunderland.
Academy Sports + Outdoors raises annual profit forecast on cost discipline, e-commerce growth
Academy Sports + Outdoors (NASDAQ:ASO) on Wednesday raised its full-year adjusted profit forecast after posting second-quarter earnings that beat analyst estimates, sending shares up 9%. The sporting goods retailer reported adjusted earnings per share of $2.31 for the quarter, topping...
Museum of Discovery and Science, Broward libraries bring hands-on learning to communities
The Museum of Discovery and Science and Broward County Library are bringing hands-on learning and character development to communities across Broward County through Character Corners, an initiative inspired by MODS’ Build a Better World: The Future Begins with You exhibit.
Trump gave $45,000 holiday gifts to Natalie Harp and two other White House aides
President Donald Trump gave sizable holiday gifts to four White House aides, according to new financial disclosures released by the administration.
Congressional Report on Potential TBIs, Mental Health Risks in Naval Aviation
The following is “Unseen Impacts: An Investigation into the Navy’s Response to Potential Traumatic Brain Injury and Mental Health Risks in Naval Aviation” published on Sept. 8, 2026, by the House Committee on Oversight and Government Reform Subcommittee on Military and Foreign Affairs. From the Report Executive Summary Following reporting by The New York Times about an epidemic of potential brain injuries in naval aviators contributing to suicide, the House Committee on Oversight and Government Reform launched an investigation to assess the Navy’s knowledge of and actions taken regarding this issue. The findings reveal a disconnect between growing concern and
The ‘amnesia tax’: How frictionless payments fuel mindless spending
The rise of frictionless payment technology may be making it easier for consumers to lose track of their spending, contributing to what the author calls “budget amnesia,” The Washington Post reports. One single mother with $80,000 in student debt reviewed a year of bank statements and discovered that her finances weren’t being undermined by major […]
BUSINESS SPOTLIGHT: Visit SEWing-FUN
The following is an interview with Nancy E. Easterbrooks, owner of SEWing-FUN at 24 Bessom St. #1, conducted by Discover Marblehead. SEWing-FUN is a creative local gem bringing the joy of sewing to Marblehead. Led by a passionate sewing coach, it’s all about learning, creating and having fun — whether you’re stitching your first project
Webinar: The Massive Scale of GLP-1s: Evolving Health, Healthcare and Markets
Watch this discussion on how GLP-1 drugs for obesity are changing the shape of U.S. healthcare. From direct-to-consumer portals to pharmacy deals, how these drugs reach patients is changing—and leading to debates over pricing and coverage. Learn how your company can be both patient-forward while also maximizing revenue in this unique environment.
BGI Genomics Launches "Digital Life Twin" Framework to Power Proactive Health
Commemorating BGI Group's 27th anniversary, BGI Genomics today introduced its Digital Life Twin framework alongside an advanced multi-omics diagnostic portfolio at the 2026 Global New Product Launch Event. Grounded in over two decades of population-scale genetic discoveries, the launch marks a decisive transition from traditional, reactive diagnostics to continuous, predictive health management across the entire human lifecycle.
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
Cosmos Update
Become director of a space station, join a galactic alliance, construct a space base and discover deep-space marvels in No Man's Sky Cosmos. Navigate space with a new star system map, strip colossal hulks for parts before hull integrity fails, recover and haul physical salvage to remote space outposts, celebrate 10 years of No Man’s Sky in the Our Journey Continues expedition, and much, much more
10 stars who were discovered in unexpected ways
Not every star is discovered in an audition room. EW rounds up 10 famous actors, like Janet Leigh and Charlize Theron, who got their big break when they least expected it.
Indiana counties' response to data centers reflects broader political risk
Indiana illustrates both the shifting political risk for data centers and the direction of the infrastructure finance discussion on this issue.
Brands are asking creators not to disclose paid partnerships: study
Influencer marketing's open secret: Brands are asking creators not to disclose their paid partnerships.
Trump Doled Out $45,000 Cash Gifts to Natalie Harp and Other Aides Last Year
The money, listed as “cash gift for the holidays,” was detailed in financial disclosure forms released by the administration.
Trump Doled Out $45,000 Cash Gifts to Natalie Harp and Other Aides Last Year
The money, listed as “cash gift for the holidays,” was detailed in financial disclosure forms released by the administration.
Scientists in Switzerland made a sponge from cheesemaking waste that captures gold from discarded electronics — after dissolving metal parts from 20 old computer motherboards, they recovered enough to melt into a 22-carat gold nugget
A Swiss lab transformed dairy waste into a gold-recovery tool, extracting precious metal from e-waste that most recyclers leave behind.
Maven Securities LTD Makes New $2.28 Million Investment in Live Nation Entertainment, Inc. $LYV
Maven Securities LTD acquired a new stake in Live Nation Entertainment, Inc. (NYSE:LYV - Free Report) during the second quarter, according to its most recent disclosure with the SEC. The institutional investor acquired 12,470 shares of the company's stock, valued at approximately $2,283,000. Other
Anthropic AI chief warns of a 'discernment tax' at work
Anthropic's AI fluency chief says knowing when not to use AI is a key skill that can help workers avoid a "discernment tax."
Epic v. Health Gorilla: “Working as Designed”
We’ve been on a bit of a legal bender since just before Labor Day, so let’s keep a good thing going! As predicted, Epic does not want its case against Health Gorilla consolidated with the data breach cases, so it filed a motion to vacate the conditional transfer. And because they had to explain to the Panel why this case is different, they put a good chunk of previously unseen Epic v. Health Gorilla discovery record on the public docket! Roll the tape! The Case Against Consolidation Before we get to the fun stuff, let’s do the housekeeping. Epic's motion boils down to three arguments (sorted in ascending order of how well they land): A judge has already decided this. Judge Olguin declined to relate the fraud action to another ELU case (Patterson v. UVA Health), holding that the two do not call for determination of substantially similar questions of law or fact. Epic asks the Panel to treat that (a Rule 42 ruling) as law of the case. The overlap is thin. The three common questions Health Gorilla and the Panel identified are neither numerous nor complex (the qualities the Panel looks for before centralizing). Moreover, they are outnumbered by the questions unique to each side: The breach cases turn on security architecture, notification timing, and patient-level access. The fraud action turns on false treatment attestations and breaches of the framework agreements. Consolidation costs more than it saves. 17 of 21 parties in the fraud action do not appear in a breach case. The cases are also at very different stages: Olguin has a scheduling order running through a January 2028 trial while the breach actions are much more nascent. I like the last two more than the first because they attack the basic economics of an MDL: there just may not be enough shared discovery here to justify dragging all the defendants and a relatively mature fraud case all the way to Florida. On the other hand (while I know exceedingly little about MDL and Rule 42), I have a hard time seeing why a district judge's decision about his own docket would control what the Panel does with the separate § 1407 question. I might be reading between the lines too much, but I sorta think Epic's own brief half-concedes this, framing the two provisions as "two sides of the same coin" but then adding "respectfully submit" (which is often lawyer speak for “we know this is a reach”). The Ladder Gets More Rungs Anyway, the arguments are not why you're here (aside from the lawyers, maybe). Back in June, we discussed how Epic was using the smaller defendants to build an evidentiary ladder toward Health Gorilla and Unit 387. Turns out discovery has been adding a few rungs of its own.
Yankees news: Discussing Judge’s greatness
Votto praises Judge upon return; the Yankees made another great bullpen, Jazz hurt?; the viable candidates for expansion
Here is what to do if healthcare costs are eating into your raises
An insurance executive explains how soaring healthcare costs eat into raises, and how workers should discuss alternative options with their company.
La Porte County Business Expo Brings Local Business Together September 17
Michigan City, IN – Businesses and community members from throughout La Porte County are invited to connect, discover local products and services, and build new contacts at the La Porte County Business Expo on Thursday, September 17, from 4:30 to 6:30 p.m. at Purdue Northwest – Westville campus. The collaborative event is hosted by the Michigan City Chamber, Westville Area Chamber, and La Porte Economic Advancement Partnership (LEAP) and will showcase businesses from across La Porte County and beyond. Attendees will have the opportunity to meet the people behind local businesses, learn about the products and services available and make
Trump gave Natalie Harp and two other aides $45,000 each in cash gifts for holidays
President Donald Trump gave Natalie Harp and two other White House aides $45,000 each in cash gifts, according to financial disclosure statements.
Connections: Sports Edition today: Hints and answers for Sept. 9, 2026, puzzle No. 716
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Trump gave $45,000 holiday gifts to Natalie Harp and two other White House aides
President Donald Trump has given substantial holiday gifts to four White House aides, according to financial disclosures released by the administration | 830 WCCO
Kaweah Health Special: Advancing Cardiac Care in the Valley
CBS47’s Kathryn Herr presented a Kaweah Health special titled “Advancing Cardiac Care in the Valley,” which featured local health experts discussing groundbreaking cardiac procedu…
Allegheny County Council proposes bill that could regulate AI use in political campaign materials
Members of Allegheny County Council on Tuesday introduced a bill that would require political candidates to disclose their use of artificial intelligence in campaign materials, an effort aimed at preventing voters from being misled by AI-generative content. If passed, the ordinance would establish disclosure requirements for AI-generated campaign content used
America 250 expenses on Inside West Virginia Politics
CHARLESTON, W.Va. (WOWK) – On this week’s episode of Inside West Virginia Politics, our guests join Rick Johnson to discuss America 250 costs, a social media lawsuit and political donations. In Seg…
Trump gave $45,000 cash gifts to Natalie Harp, two other close aides
Financial disclosures show the sums were equivalent to nearly one-third of each of their salaries. Experts say the gifts are without precedent and may violate the law.
One Area Trail Blazers Must Win On-Court This Season
High-flying highlights won't save Portland if transition defense lags. The Blazers must match their offensive electricity with disciplined back-pedaling to transform from a highlight reel into contenders.
Chinese scientists find a hidden atomic structure that unlocks methane
Scientists found that a tiny atomic structure that forms on nickel oxide during methane conversion is more effective than the metallic nickel long believed to drive the reaction. The discovery allowed a low-nickel catalyst to rival one containing 10 times more metal, potentially opening the door to cheaper and more efficient industrial catalysts.
St. Louis Cardinals vs San Francisco Giants Game Discussion Tuesday
The St. Louis Cardinals return to Oracle Park Tuesday night for game 2 against the San Francisco Giants. Quinn Mathews gets the start for the Cardinals while Landen Roupp gets the ball for the Giants. First pitch is scheduled for 8:45pm central time and the game broadcast will be available via Cardinals.tv.
Ubisoft joins Xbox's disc-to-digital program, with more publishers to follow
Some outlets were highlighting Ubisoft's lack of involvement in Xbox's disc-to-digital program. Perhaps we should remind ourselves that it's still in Alpha testing.
18 Sports Commentary – the first day of the school year
ELMIRA, N.Y. (WETM) – It’s time for another special 18 Sport Commentary. On this edition, we discuss the very first day of school in the New York region of The Southern Tier. The first day of school symbolizes much more than just being the first day to go back to the classroom. It’s symbolic of […]
D-backs @ Royals discussion
Today’s Lineups DIAMONDBACKS ROYALS Lars Nootbaar – DH Carter Jensen – C Ketel Marte – 2B Bobby Witt – SS Gabriel Moreno – C Vinnie Pasquantino – 1B Geraldo Perdomo – SS Salvador Perez – DH Corbin Carroll – RF Michael Massey – 2B Nolan Arenado – 3B Nick Loftin – 3B Tommy Troy – […]
Alaska review finds potential financial disclosure issues involving 91 candidates
A preliminary Alaska Department of Law review found potential financial disclosure discrepancies involving 91 candidates, but did not determine whether any laws were violated.
Dahlstrom reverses course, will certify Taylor and Tagle for November ballot
Lt. Gov. Nancy Dahlstrom reversed her August 31 decision and will certify Treg Taylor and Jose Tagle after a preliminary review raised questions about financial disclosure recommendations.
Putin and Trump discuss Ukraine in 'extremely frank' call
Washington has been pushing for fresh face-to-face talks between Moscow and Kyiv to reach a peace deal
One Small Step: Sheriff and nonprofit leader discuss parenting amid political backdrop
Matt Carr and Stefani Wells recall their earliest political experiences and how that has shaped them today, as parents.
Democratic socialist candidates stirred the primary election pot. But can they win in November?
An MSU Denver political expert discusses what’s behind their emergence, what they stand for and whether they can achieve lasting impact.
William O'Dowd IV Discloses Investment at Dolphin Entertainment with 19.0% Stake
William O'Dowd IV, the CEO of Dolphin Entertainment, Inc., reported beneficial ownership of 19.0% of the company's common stock. He filed a Schedule 13D on Sep. 08, 2026, after an earlier note exchange and a pre-set buying plan in 2025. The position includes common shares and the right to convert c…
NASCAR CEO on future business growth: All about partnerships
Steve O’Donnell, NASCAR CEO, and Matt Hong, USA Sports president, join 'Closing Bell' to discuss the business of NASCAR, how to keep business momentum and much more.
Joe Biden shares health update after prostate cancer diagnosis while issuing warning to others
Joe Biden revealed his radiation treatment from last fall "worked as intended" as he urged men to discuss prostate cancer screening with their doctors.
Independent Kansas health systems launch shared services organization
Five Kansas health systems have launched a regional collaboration, called Astra Health, to pool resources and coordinate services while retaining their independence. | Astra Health's five founding members, who serve more than half a million patients annually, hope to improve quality and trim costs at scale while maintaining their independence.
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations
The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.
Pamplin+ transforms undergraduate business curriculum into four-year experiential internship
Launching in fall 2026, Pamplin+ transforms the Pamplin College of Business undergraduate experience through hands-on learning, required internships, mandatory agentic AI coursework, and cross-disciplinary corporate projects.
Supporting small business across North Dakota
ND SBDC State Director Tiffany Ford joins ‘North Dakota Today’ to discuss the organization’s statewide impact
Sports law professor explains the Clippers and Kawhi Leonard’s NBA punishments
Ken Jacobsen, director of Temple Law’s sports law program, discusses the recent Kawhi Leonard scandal and the heavy punishments being administered by the NBA.
Sports law professor explains the Clippers and Kawhi Leonard’s NBA punishments
Ken Jacobsen, director of Temple Law’s sports law program, discusses the recent Kawhi Leonard scandal and the heavy punishments being administered by the NBA.
Father-Son Duo Launch A Talent Discovery And Entertainment Ecosystem For Independent Performers
Father-son duo launch a talent discovery and entertainment ecosystem for independent artists because likes alone don't pay the bills.
An AI Formalized and Verified Fermat’s Last Theorem in 11 Days, a Task Expected to Take Years
Claude did not rediscover the proof. It made the existing one machine-checkable.
SEC sets meeting to discuss booting LSU from conference
The Tigers didn't ultimately add any NFL players to their roster ahead of Week 1, but that hasn't stopped the SEC presidents' crusade against them.
Drug developed for lung disease may slow biological aging in surprising ‘bonus’
Rentosertib, an AI-discovered drug for idiopathic pulmonary fibrosis, made patients appear three to four years biologically younger in a clinical trial.
Louisiana’s marine research collaboration becomes a political battleground
A select group of Louisiana higher ed leaders are discussing what to do with the state's marine research consortium
Scientists Discover Bacteria That Can Make Testosterone Near the Prostate, With Potential Implications for Cancer
A newly discovered bacterial pathway turns a common steroid precursor into testosterone.
Creators Mean Business: Why This Growing Buyer Community Matters and What Exhibitors Need to Know
In this Exhibitor Town Hall, members of the NAB Show Creator Council share firsthand insights into how creators discover and evaluate technology.
Environmentalist photographer kicks off A.D. White Professors-at-Large series
James Balog will discuss his work documenting the world-wide rapid retreat of glaciers on Sept. 17 as part of the visiting professors program.
AI for better food safety: How tech helps uncover emerging outbreaks
Food-safety expert Willette M. Crawford discusses AI's role in preventing outbreaks and calling for recalls. She said regulatory challenges remain.
Warner Bros. Discovery Home Entertainment Announces The End of Oak Street
The End of Oak Street, the wildest ride to hit theaters this summer, from writer/director/producer David Robert Mithcell (It Follows), debuts
'Turning blind eye' to AfD win further angers voters, analyst warns
Chancellor Merz's government must recognise the far-right AfD's victory in Saxony-Anhalt and voter discontent that led to the win, or further cement its downfall, an expert on East German politics warned.
Sanford Health Patient Advances Suit Over Meta Data Disclosures
Sanford Health Corp. failed to convince a federal judge to toss a proposed class action alleging the Minnesota-based health system collected and disclosed patients’ personal information in violation of state and federal laws.
Democrats Demand Trump Administration Halt Collection of Patients' ER Records
Senate and House Democrats say the Trump administration’s plan to collect patients’ medical data violates privacy and will discourage people from seeking medical care.
Scientists Discover the 7 Stages a Meteoroid Goes Through Before Hitting Earth
An analysis of 75 meteorite falls identified seven distinct processes that occur as space rocks melt, break apart, and slow down before reaching the ground. A space rock entering Earth’s atmosphere does far more than simply “burn up.” By examining 75 meteorite falls recorded in videos and photographs, researchers identified seven distinct stages that shape
Meta Removes Iran-Linked Network That Faked American Personas to Sway US Political Debate
The Combat Antisemitism Movement (CAM) welcomes Meta’s recent removal of an Iranian regime-linked network that disguised its origins while seeking to influence American political discourse. Meta disclosed the takedown on Aug. 27 in its H2 2026 Adversarial Threat Report. The network consisted of four Facebook accounts and 31 Instagram accounts linked to actors based in […]
Scientists find a huge 10-sided pattern in the clouds over Saturn's south pole
Scientists have discovered an enormous 10-sided wave pattern in the icy ammonia clouds over Saturn's south pole
MedStar Washington Hospital Center nurses host community forum on maternal health care cuts, the future of health care in DC
Union registered nurses at MedStar Washington Hospital Center in Washington, D.C. will hold a community forum on Wednesday, Sept. 9, 2026, to discuss the closure of postpartum unit 5F at Washington Hospital Center, the devastating impact of Medicaid cuts in DC, and building a health care system that works for us all.
‘Science at the Fifty-Third Degree’ humanizes research advancements through conversation
Episodes highlight the collaborative nature of science, and expand accessibility of discoveries happening at the university.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
UC Berkeley Law event targets Trump science policies as ‘censorship’
The University of California, Berkeley School of Law organized an Aug. 25 discussion focused on resisting censorship and protecting academic freedom in scientific research.
U.S. Senator Reed discuses efforts to reverse Trump administration's cuts to health care
U.S. Senator Jack Reed is set to discuss the effort to reverse the Trump administration’s cuts to the nation’s health care system.He will discuss these on Tuesd
Bailey Stockton reflects on special touchdown from Aaron Philo
Bailey Stockton discussed reuniting with Aaron Philo, scoring in his Florida debut and the Gators' offensive potential entering Week 2.
Griffin’s 'Healthy U; To Discuss Hispanic Health
Scheduled for Sept. 16.
It’s harmful for professors to preach their political beliefs
Senior staff writer Abby Breidenbach discusses the need for political discourse in the classroom and why that is harmed when a professor preaches their own beliefs.
It’s harmful for professors to preach their political beliefs
Senior staff writer Abby Breidenbach discusses the need for political discourse in the classroom and why that is harmed when a professor preaches their own beliefs.
‘Plastic pollution hotspots’ spawn a public health crisis across Latin America
Since China banned the import of plastic waste in 2018, plastic pollution has been having a growing impact on the people and ecosystems of Latin America. As the region imports an increasing amount of the world’s used and discarded plastic, new research shows that waste infrastructure in many countries is already buckling under the strain […]
Deconstructing LSD for Therapeutic Discoveries
UC Davis researchers have stripped down LSD to the base features responsible for its hallucinogenic and therapeutic effects.
Xbox Fans Report Companies ‘Not Participating’ In Disc-To-Digital
Fans report Sega, Ubisoft, Square Enix, and Bandai Namco games are ‘not participating’ in the newly introduced service
The Lewer Agency Inc. BizSpotlight
Discover the latest press releases from The Lewer Agency Inc. with the Kansas City Business Journal's BizSpotlight
Penélope Cruz, Javier Bardem on Speaking Out on Politics at Venice
Penélope Cruz and Javier Bardem discussed their willingness to speak out about politics at a Venice Film Festival press conference for 'Bunker.'
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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