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NH candidates for governor, U.S. Senate, Congress clash over...
At a Manchester forum, New Hampshire candidates clashed over housing, energy, healthcare and other costs as affordability emerged as voters’ central concern. ...
Tampa technical institute expands bilingual health care career training
Aguilas International Technical Institute has opened a larger Tampa facility, expanding bilingual career training as health care demand grows locally.
Ex-Spur Jeremy Sochan becomes a Legend
The Dallas Legends used the top pick in Saturday's G League draft on Sochan, who will look to salvage an NBA career that has not gone as expected for the former lottery selection.
Barcelona host Real Madrid in anticipated Clásico clash
2026-10-25T20:12:58ZThere have been a few crunching tackles on both sides in the last few minutes and now the benches have taken exception as there is a little coming together in the center of the par...
Cardinals-Broncos Week 7 discussion thread
Talk about the Cardinals games with your friends at Revenge of the Birds.
Des Moines bishop says White House 'exploited' visit for politics
Bishop William Joensen was one of several invited to the White House for a private meeting they say is being used for "partisan political purposes."
Why is the U.S. accusing Canada of election interference?
the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again
Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Christian McCaffrey able to return to Week 7 game
49ers RB Christian McCaffrey returns to Week 7 game after missing time with thigh issue
After arts festival, San Francisco's Mid-Market businesses look for signs of a turnaround
“Business as usual” – PSG coach refuses to give his players an excuse after triple blow
PSG are missing some important players, but that’s not an excuse says manager Luis Enrique, who still expects the best.If you enjoy PSG Talk coverage and want to see more of it, add us as a preferre...
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids
Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race
Blanche told CNN's “State of the Union” that President Donald Trump, who said Friday that he was "the one that said do it,” is not trying to overturn state election results “in any way, shape or form” on the cusp of the Nov. 3 election.
‘There's a risk we do have a disconnect’: Business on Australian Labor
Chamber of Commerce CEO Andrew McKellar appears to suddenly be everywhere, all at once.
Cracking a smile regularly may be good not just for your mood but for your health
Reminding yourself to smile often can not only make more friendships but it can also make you feel better.
Olympiacos May Attempt to Sign Genoa Midfield Maestro This Winter
Olympiacos are poised to reignite their pursuit of Morten Frendrup, testing Genoa's resolve after a rejected summer bid for the consistent Danish engine room specialist.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...
Steelers stock report after Week 7 win over Saints
Stock up, stock down, after the Steelers Week 7 win in Paris over the New Orleans Saints.
Projections for Cleveland Guardians’ Arbitration Eligible Players
The Cleveland Guardians have several key players arbitration-eligible this offseason.
Sunday Open Thread
There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]
What Will It Take for Rockies to Make World Series?
It's been since 2007 for the Colorado Rockies to be a part of the World Series. Is there any hope for a return to the Fall Classic?
Lady Gaga dancer reveals why he thinks she’ll succeed at motherhood
Lady Gaga’s backup dancer, who slid off stage mid-performance during last year’s Mayhem Ball world tour, is opening up about why he believes the singer will succeed at motherhood.
Carrick ‘not expecting’ Man United crisis talks despite Bournemouth defeat
Michael Carrick said he is ‘not expecting’ imminent talks about his future despite Manchester United’s latest defeat.Carrick’s position as head coach looks under threat after Manchester United...
Steelers beat Saints to win first NFL game in Paris
The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.
'Sound of Music' star Julie Andrews spotted in rare Hamptons outing weeks after turning 91
Julie Andrews, 91, was photographed in the Hamptons wearing a purple raincoat and pink sunglasses in a rare public outing in the coastal city.
This Switch 2 sequel accessory was a few millimeters away from being good
The right stick gets in the way.
Jaylen Warren surpasses 100-yard mark in Week 7
Steelers RB Jaylen Warren rushes for at least 100 yards for third time this season
Broncos Place Linebacker, Running Back On Injured Reserve
The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.
Orlando Science Center hosts Halloween party
Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.
Warriors honor Bay Area sports reporter Michael Wagaman
After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
Kings' Veterans Praise Rookie Acuff After 33-Point Showing
The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?
Memorial Health celebrates staff with trunk-or-treat
Memorial Health went all out for its annual trunk-or-treat event, celebrating team members and their families.
Bloomington business continues to blossom
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Texas opens as heavy favorite against Mississippi State
The Longhorns are three-score favorite as they welcome the Bulldogs to Austin.
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
Americans have a grief problem we still call a mental health problem
OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns
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How Braves should handle $42 million Jurickson Profar situation
This could be one solution for the Braves.
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
Who can buy California's voter rolls and why?
Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.
South Texas Health System (@stxhealthsystem)
1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.
Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake
The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.
Michigan Gov. Gretchen Whitmer says America is ready to elect a Woman
The Michigan governor did not deny that she was exploring a potential run for president in 2028.
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity
A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.
Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.
World's Fastest Lawnmower Company Is Officially Going Out Of Business
Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’
The Heat’s Giannis Antetokounmpo era is off to a rough start.
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026
With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …
Opinion - How Trump learned to stop worrying and love space science
He recognizes a cool thing when he sees it.
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Investment driving growth at NWS Crane
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Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Denzel Ward to take part in pregame warmups
Denzel Ward's status for Week 7 remains in question
Health board still paying for research despite criticism over patient benefit
Betsi Cadwaladr health board was due to pay Bangor University £110,686 for two researchers.
r/opensource just banned AI, non-English speakers and more
The opensource subreddit’s new rules against AI have sparked a revolt.
Adam Schiff responds to DOJ’s Alaska threat: ‘it’s Alaska’s business’ to run elections
In an exclusive interview with Meet the Press, Sen. Adam Schiff (D-Calif.) says “it's not the federal government's business to run Alaskan elections,” after the Justice Department sued to block certification of Alaska’s election results if Sen. Dan Sullivan loses, due to another candidate with the same name appearing on the ballot.
NFL Week 7 Game Discussion and Open Thread
Talk about all the Week 7 NFL games with us here!
NH's Business: Healthcare affordability for NH residents
Fred Kocher sits down with Maria Proulx with Anthem Blue Cross, Blue Shield to talk about healthcare affordability for NH residents.
Open Thread, Sunday, October 25: How we doing today, folks?
Your daily source for off topic chatter with the MMA Mania faithful.
Arkansas basketball displays true toughness against Gonzaga
The big story of the win over Gonzaga: These Hogs play defense
How to build a police state
To understand where Trump is trying to take the US, we should look to the authoritarian playbook of his favorite ally: El Salvador’s Nayib Bukele
Tractor-trailer crash closes part of US-70W Business
Two lanes are closed on US-70W Business after a crash involving a tractor-trailer.
Pat Surtain II unlikely to play
Pat Surtain has good chance to suit up in Week 8 due to ankle injury
2026 Vanderbilt Football Mailbag #9: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. It’s becoming more and more obvious we’re highly unlikely to win another game this season. Our defensive calls make no sense, we’ve got an uber-talented but uber-raw QB learning on the jerb, and Barton Simmons’ decision to staff our O-Line exclusively with matadors has […]
Steelers Get Good News on Rico Dowdle
Pittsburgh Steelers running back Rico Dowdle (knee) is active for Sunday’s game against the New Orleans Saints in Paris after […]
🚨 Barça's squad to face Real Madrid
Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...
Political analysis favors Mendoza over Ciscomani
The Cook Political Report has switched its assessment of the congressional race for the House seat from a “toss-up” ranking to “Leans Democratic.”
Arsenal squad & fixtures for the 2026 Messi Cup
The 2026 Messi Cup kicks off on Sunday, with Arsenal’s squad and fixture list for the tournament now confirmed.Photo by Elsa/Getty ImagesThe Arsenal u16s will take part in the Messi Cup this year, w...
Interest rates unlikely to reach 4.75% by next summer, say City economists
Experts say Bank of England unlikely to increase rates by full percentage point – and could lower them by end of 2027
12 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Google’s AI search changes upended online publishing
Some publishers are preparing for a future without Google.
What happened to the cast of ‘I Dream of Jeannie’? See the stars more than 55 years later
‘I Dream of Jeannie’ paired Barbara Eden’s genie with Larry Hagman’s astronaut for five seasons of magic. See what became of the cast more than 55 years after the final episode.
Scientists Trapped an Antimatter Particle for Months to Study Its Secrets
These elusive and reactive particles have been challenging to hold on to and even more challenging to study, but a new method paves the way for tests on the differences between matter and antimatter.
This Week in Purple: Around The World (Series)
Colorado Rockies news and links for Sunday, October 25th, 2026
Patriots rooting guide for NFL Week 7
Rooting information, kickoff times, TV schedule and more for NFL Week 7.
Gyökeres May Not Be Scoring, But He’s Helping Arsenal Win
Viktor Gyökeres is still waiting for his first Premier League goal of the season, and for a striker of his reputation, that’s always going to attract attention.But are we becoming too focused on wh...
Browns Week 7 fantasy start-sit: Boston, Judkins, Fannin, Concepcion
Tennessee has allowed the 10th-most half-PPR points to receivers, while Dylan Sampson’s return from injured reserve threatens Quinshon Judkins’ receiving work.
South Texas Health System (@stxhealthsystem)
2 likes, 1 comments - stxhealthsystem on October 25, 2026: "One Last Chance to Think Pink: Breast cancer remains the most common cancer among women after skin cancer, making routine screenings and early detection more important than ever. Mammograms can help identify breast cancer before symptoms appear, when treatment options may be most effective. Last week, South Texas Health System McAllen celebrated breast health and preventive care with a special Mammo Monday event featuring the vibrant sounds of mariachi music at the hospital’s main entrance. The celebration reflected STHS' ongoing commitment to encouraging women to prioritize their health through regular screenings. Now, there’s one final Mammo Monday remaining! Join us at STHS ER Mission on October 26 from 8 a.m. to 5 p.m. for the last breast cancer event of 2026. During the event, attendees can: 🎀 Learn about breast cancer screening options 🎀 Schedule a mammogram appointment 🎀 Receive a complimentary goodie bag while supplies last To help make preventive care more accessible, South Texas Health System is also offering reduced self-pay rates* throughout October: • 2D Mammogram: $100 • 3D Mammogram: $155 • Bone Density Screening: $160 A screening today could make all the difference tomorrow. Make your health a priority and encourage the women you love to do the same. For breast health resources and information on the Think Pink campaign, visit the link in our bio. *If not already a covered benefit of your insurance.".
