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Why Kyle Shanahan believes Mike Evans, Christian Kirk picked 49ers over others

Veteran wide receivers Mike Evans and Christian Kirk could have made more money elsewhere, but there was a common reason why they picked the 49ers.

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Mar 23 • 10:34 AM EDT • Sports • nbcsportsbayarea.com
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return

A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.

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Mar 23 • 10:04 AM EDT • Science • scitechdaily.com
Apple Reportedly Preparing 'Biggest Set of iPhone Revamps' Ever

Apple is working on "the biggest set of iPhone revamps in the product's history," according to the latest word from Bloomberg's Mark Gurman. Specifically, he is referring to the long-rumored foldable iPhone, as well as an ambitious 20th-anniversary iPhone with a truly "edge-to-edge" design.

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Mar 23 • 9:28 AM EDT • Technology • macrumors.com
What’s the new 'Background Security' on the iPhone? What we know.

Apple's new Background Security Improvements operate between software updates, providing "lightweight security releases."

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Mar 23 • 9:11 AM EDT • Technology • usatoday.com
Oppo teases global Find X9 Ultra launch as new OnePlus shutdown rumors swirl

Oppo is busy teasing its global launch of the Find X9 Ultra but, meanwhile, a new rumor suggests that OnePlus...

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Mar 23 • 9:10 AM EDT • Technology • 9to5google.com
Exclusive: Prenuvo expands full-body MRI protocol. What's new?

Prenuvo is launching a new bloodwork component to complement its full-body MRIs. Here's what to know.

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Mar 23 • 9:00 AM EDT • Health • usatoday.com
Add this one line to your AI prompts for faster, better answers

This handy prompt add-on can save you from tedious back-and-forths with your AI.

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Mar 23 • 9:00 AM EDT • Technology • pcworld.com
WSU launches bilingual video series to help beekeepers improve colony health

Researchers with WSU's Honey Bee and Pollinators Program have produced a new video series giving novice keepers a strong introduction to best practices and the science of apiculture, in both Spanish and English.

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Mar 23 • 9:00 AM EDT • Health • news.wsu.edu
Trump to Maria Bartiromo: Iran wants to make a deal badly, could be within 5 days or sooner

Maria Bartiromo reports that President Donald Trump says Iran ‘wants to make a deal badly’ as he orders a five-day pause on planned strikes against key infrastructure, signaling ongoing high-level talks and triggering a sharp market rebound.

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Mar 23 • 8:58 AM EDT • Business • foxbusiness.com
Blue Jays extend manager John Schneider, GM Ross Atkins following World Series appearance

The Blue Jays are locking up two architects of the team's World Series run.

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Mar 23 • 8:35 AM EDT • Sports • sports.yahoo.com
Danone to buy protein shake maker Huel as health nutrition craze drives demand shift

Merging the companies is an opportunity in fast-growing nutrition space, said Danone CEO Antoine de Saint-Affrique.

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Mar 23 • 8:14 AM EDT • Health • cnbc.com
A surprising foam discovery could change everyday products

Foams have long baffled scientists because liquid drains from them far sooner than theory predicts. New research shows the reason: the bubbles don’t stay put—they rearrange, opening pathways for liquid to escape. The key factor is the pressure needed to shift bubbles, not just push liquid through them. This insight reshapes how we understand foams and could improve everyday products.

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Mar 23 • 8:00 AM EDT • Science • sciencedaily.com
Small Business Promotion Week: Hey Honey Marketplace

Jennifer Reeves, nurse turned boutique owner, came up with the idea for Hey Honey Marketplace, a boutique on Abram Street that aims to not just be a store but a community gathering place for women.

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Mar 23 • 8:00 AM EDT • Business • arlingtontx.gov
Building a Culture of Health: BJACH Opens Armed Forces Wellness Center at Fort Polk

FORT POLK, La. — Bayne-Jones Army Community Hospital marked a significant step forward in supporting warfighter readiness and community well-being with the grand opening of its new Armed Forces Wellness Center on March 23. The center, located on the first floor inside BJACH, provides Soldiers, Families, civilian employees and beneficiaries with access to personalized health assessments, education and coaching designed to improve overall health and performance.

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Mar 23 • 8:00 AM EDT • Health • dvidshub.net
How the term ‘neurodivergent’ moved from activists to pop culture

Nick Minaj is one of the most recent Trump supporters to identify herself as “neurodivergent,” embracing a narrow definition of a once-niche term commonly associated with autism and ADHD.

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Mar 23 • 8:00 AM EDT • Politics • 19thnews.org
The debate over Trump’s mental health: ‘Malignant narcissist ’ or ‘superhuman president’?

While some warn of the danger of having someone suffering from ‘cognitive decline’ in the White House, his inner circle attributes his outbursts to his iconoclastic personality

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Mar 23 • 7:46 AM EDT • Health • english.elpais.com
The problem with Trump promoting "gold standard science"

This simplistic branding is confusing, misleading, and potentially harmful to scientific literacy.

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Mar 23 • 7:30 AM EDT • Science • motherjones.com
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Trump orders War Dept to postpone strikes on Iranian energy sites, citing 'productive' talks to end war

President Donald Trump, in an all-caps post early Monday morning, declared progress toward "resolution" of the war on Iran.

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Mar 23 • 7:13 AM EDT • Politics • foxnews.com
Samsung's Galaxy S26 will get Apple AirDrop support starting today

The feature was first launched on Pixel 10 phones last year.

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Mar 23 • 7:04 AM EDT • Technology • engadget.com
Peace of mind was Mikaela Shiffrin's biggest victory in 2026 Winter Olympics

Olympic legends Mikaela Shiffrin and Simone Biles are fierce advocates for athletes prioritizing their mental health.

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Mar 23 • 7:03 AM EDT • Health • usatoday.com
‘President Trump is right’: The White House’s go-to line about Trump’s false claims

President Donald Trump’s White House spokespeople have a favorite two-step reply when reporters ask them to comment on one of Trump’s false claims.

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Mar 23 • 7:00 AM EDT • Politics • cnn.com
Browns coach Todd Monken’s strong suit is blunt honesty without the politics

Monken's authenticity and commitment are strengths, said the Southern Miss AD who hired him for his only other head-coaching job in 2013.

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Mar 23 • 7:00 AM EDT • Politics • nytimes.com
Report: iPhone Air is about twice as popular compared to the Plus model it replaced

According to cellular network data from Ookla, the iPhone Air is about twice as popular compared to the iPhone 16...

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Mar 23 • 6:53 AM EDT • Technology • 9to5mac.com
Sound Advice: A quality soundbar to take your home entertainment system to the next level

Q. You mentioned that the TCL QM9K television sounded so good that an external soundbar was not necessary. I find that most televisions sound awful,...

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Mar 23 • 6:30 AM EDT • Entertainment • post-gazette.com
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Banijay Entertainment Dials Up Global Scripted with Premium Series Mania Slate

Media and entertainment powerhouse, Banijay Entertainment, today unveils its premium scripted offering for Series Mania, showcasing a broad range of high-end drama from across its global portfolio. As the number one European studio in scripted, with more than 100 titles launching each year, the company continues to demonstrate its scale, creative strength, global reach and […]

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Mar 23 • 6:26 AM EDT • Entertainment • banijay.com
Mailer in Germantown school election has one big problem

An outside political group urges Germantown School District voters to re-elect a candidate who isn't on the ballot.

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Mar 23 • 6:05 AM EDT • Politics • jsonline.com
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There’s little information about a large measles outbreak in Florida, so we went to see it

One of the largest measles outbreaks the US has seen in decades erupted at Ave Maria University in Florida, but very little information was being shared with the public. So CNN went to the small Florida town to learn what’s driving the case count.

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Mar 23 • 6:00 AM EDT • Health • cnn.com
New York approves cannabis for anxiety. Science says it may not help

A Lancet Psychiatry study found no evidence cannabinoids treat anxiety, PTSD. In NY, any practitioner can certify a patient for medical cannabis for any condition they deem appropriate.

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Mar 23 • 6:00 AM EDT • Science • timesunion.com
'ET's' archive has William Shatner on a whale and a young Taylor Swift

'Entertainment Tonight' is digitizing and preserving its archive of 45 years of interview set visits and red carpet walks, which include gems like George Clooney's first interview.

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Mar 23 • 6:00 AM EDT • Entertainment • latimes.com
'A towering figure in French politics': reactions to Lionel Jospin's death pour in

Lionel Jospin, Socialist prime minister of France from 1997 to 2002, has died.

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Mar 23 • 5:44 AM EDT • Politics • reuters.com
German men's biathlon coaches stay, women's coaches leave after flop

Tobias Reiter und Jens Filbrich have kept their jobs as coaches of Germany's men's biathlon team despite their equivalents in the women's team leaving their roles. The season which finished on Sunday was hugely disappointing for the former biathlon powerhouses, with just one Olympic bronze medal and no World Cup wins.

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Mar 23 • 5:29 AM EDT • Sports • sports.yahoo.com
Science Explains Why You Wake Up at 3 am, and How to Go Back to Sleep

About one in five people have middle-of-the-night insomnia.

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Mar 23 • 5:07 AM EDT • Science • inc.com
An end to the battle between touchscreens and long fingernails is on the horizon

Anybody who has tried to use a smartphone or tablet with long nails knows that there's a learning curve. Rather than effortlessly tapping with a fingertip, you must awkwardly lay the pads of your fingers ...

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Mar 23 • 5:00 AM EDT • Technology • phys.org
Sheffield business owners 'don't feel safe' next to illegal waste site

An Attercliffe dumping ground is identified as one of the worst in the country by the government.

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Mar 23 • 4:13 AM EDT • Business • bbc.com
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Coeur d'Alene's science guy

Ahead of his retirement in May from the teaching staff at Arizona State University, behavioral neuroscientist Brian Smith has put his focus into making science more accessible to more people. “There's a lot of misunderstanding what science is,” Smith said.

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Mar 23 • 4:08 AM EDT • Science • cdapress.com
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‘Anyone but Labour’ or ‘anyone but Reform’? Clash of animosities likely to define May local elections

While Labour braces for a rout that could see off Starmer, a rising drive to keep out Farage is complicating expectations

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Mar 23 • 3:00 AM EDT • Politics • theguardian.com
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Best selling author Marie Benedict to talk at the United Theatre

WESTERLY — Marie Benedict, the Pittsburgh-based author known for using real — mostly forgotten — women as inspiration for her bestselling works of historical fiction, was on the phone Tuesday

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Mar 23 • 3:00 AM EDT • Entertainment • thewesterlysun.com
Experience shone through for Manchester City at Wembley against Arsenal

Manchester City claimed the first piece of silverware for the 2025/26 season with their 2-0 win over Arsenal at Wembley in yesterday’s Carabao Cup final. A second half brace from Nico O’Reilly was...

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Mar 23 • 2:35 AM EDT • Sports • sports.yahoo.com
Yankees set to leave Florida in good health one year after spring from hell with one question looming

And just like that, Camp Snooze is over — at least the Florida portion.

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Mar 22 • 11:50 PM EDT • Health • nypost.com
Michigan State basketball time, TV channel set for Sweet 16

Michigan State basketball knows when it will be playing, even before it knows its opponent in the Sweet 16 in Washington on Friday night.

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Mar 22 • 11:05 PM EDT • Sports • sports.yahoo.com
These Michigan U.S. Senate candidates took money from ICE contractors

Anti-ICE messaging is expected to be featured prominently in Michigan's hotly contested U.S. Senate Democratic primary.

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Mar 22 • 11:01 PM EDT • Politics • detroitnews.com
Two new features are officially announced today for the Google Messages app

Google makes it easy to notify members of an RCS group chat while your wife isn't the only reason you're taking out the trash.

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Mar 22 • 10:46 PM EDT • Technology • phonearena.com
Samsung reverses big S Pen change for Galaxy S27 Ultra after bold experiment fails

Samsung has backed away from one of its more ambitious S Pen experiments for next year’s Galaxy S27 Ultra, choosing to stick with its long-standing digitizer-based input system after testing a radically thinner alternative. According to ETNews, Samsung had been exploring a new pen technology that could eliminate the digitizer layer inside the display. The […]

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Mar 22 • 10:44 PM EDT • Technology • sammyfans.com
One dead after shooting at Last Call Sports Bar in Jackson

One person is dead after a shooting at Last Call Sports Bar early Sunday morning.

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Mar 22 • 10:17 PM EDT • Sports • wlbt.com
Column: Accessing mental health support shouldn’t require a walk across campus

"While well-intentioned universities have developed mental health support systems, they are poorly designed to meet students’ needs."

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Mar 22 • 9:40 PM EDT • Health • dailytarheel.com
Alvaro Folgueiras hits game-winner to lift Iowa past No. 1 Florida, into first Sweet 16 since 1999

Florida's hopes at back-to-back national titles are gone.

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Mar 22 • 9:40 PM EDT • Sports • sports.yahoo.com
Arizona Diamondbacks Spring Training Gameday Thread, #30 @ Padres

Roster moves The Arizona Diamondbacks made the following roster moves and have 33 players in camp. Optioned to Triple-A Reno: Reassigned to Minor League camp: The first of these is a bit of a surprise. Only yesterday, I was noting how Abner seemed to have the inside track for left-handers job, after the recent meltdowns […]

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Mar 22 • 9:00 PM EDT • Sports • sports.yahoo.com
Jerry Hanlon, longtime Michigan football coach, dies at 96

"Michigan Athletics has lost one of the finest ambassadors and mentors our football program has ever known," U-M AD Warde Manuel said in a statement.

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Mar 22 • 8:34 PM EDT • Sports • sports.yahoo.com
Alcaraz eyes clay court season after early Miami exit

World number one Carlos Alcaraz remained confident his game is improving despite a third-round exit at the Miami Open, and after a few days to reset he'll be turning his attention to the clay court season.My mind right now is to take some days off, to reset my mind, reset the batteries, be ready and in good shape for the clay season."

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Mar 22 • 7:44 PM EDT • Sports • sports.yahoo.com
Hackaday Links: March 22, 2026

On Friday, Reuters reported that Amazon is going to try to get into the smartphone game…again. The Fire Phone was perhaps Amazon’s biggest commercial misstep, and was only on the market…

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Mar 22 • 7:00 PM EDT • Technology • hackaday.com
Why Have Patriots Not Done More To Address Pass Rush?

The New England Patriots had just 35 sacks last season, ranking near the bottom of the league in the regular season.

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Mar 22 • 5:47 PM EDT • Sports • sports.yahoo.com
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Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
The Boston Celtics are terrifying to their opponents again

Instead of mailing it in for a season, the Celtics have rebuilt themselves into a contender again against all odds.

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Mar 22 • 2:00 PM EDT • Sports • sports.yahoo.com
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Buffalo Museum of Science celebrates 50% completion of upcoming Science Stadium Exhibit

The Buffalo Museum of Science marked a major milestone in its $3 million Science Stadium exhibit, announcing on March 20 the project is now 50% complete ahead of its planned

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Mar 22 • 1:33 PM EDT • Science • beenews.com
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Mississippi State Health Officer Dr. Daniel Edney, a Vaccine Proponent, Is Under Consideration to Lead the CDC

Dr. Daniel P. Edney, Mississippi’s state health officer and head of the Mississippi State Department of Health, is now under serious consideration to lead the CDC.

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Mar 22 • 1:10 PM EDT • Health • mississippifreepress.org
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Apple’s busy March continues with three notable arrivals this week

Apple has had a jam-packed March so far after launching seven new products and surprisingly announcing an eighth. Looking ahead,...

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Mar 22 • 11:47 AM EDT • Technology • 9to5mac.com
Messi expected to play, NYCFC vs. Inter Miami live updates

Lionel Messi and Inter Miami shift their focus to MLS play with a matchup against New York City FC at Yankee Stadium on Sunday, March 22.

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Mar 22 • 11:45 AM EDT • Sports • usatoday.com
You're Incredibly Smart If You Can Answer Even ONE Question On This Science Quiz

It's time to channel your inner Bill Nye.

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Mar 22 • 11:31 AM EDT • Science • buzzfeed.com
Apple iPhone Fold Might Have A Sun Glare Problem

Given the already high reflectance of iPhone displays, Apple's use of a CoE filter on the iPhone Fold can lead to a sun glare problem.

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Mar 22 • 11:05 AM EDT • Technology • wccftech.com
‘Project Hail Mary’ Author Andy Weir Bases His Blockbusters in Science

The bestselling writer and self-described “dork” explains how he crafts upbeat space-set thrillers from dire scenarios only expertise can solve.

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Mar 22 • 10:00 AM EDT • Science • rollingstone.com
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Drew Barrymore says talk show audience member once criticized her dating profile

Drew Barrymore is remembering the time an audience member on her talk show gave his honest thoughts about her dating profile: 'I would probably run away.'

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Mar 22 • 9:30 AM EDT • Entertainment • ew.com
Urgent Apple warning: Update your iPhone, iPad now

Roughly 25% of all iPhones are operating a version of iOS 18.

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Mar 22 • 9:20 AM EDT • Technology • al.com
Bucs facing a tough decision with Baker Mayfield in 2026

The Bucs have to get the contract situation with Baker Mayfield solved sooner rather than later.

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Mar 22 • 9:04 AM EDT • Sports • sports.yahoo.com
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'Everybody Loses' author discusses the meteoric rise of sports gambling

Two years ago, Americans bet $120 billion on sports, a 27% increase from the previous year. That figure grew to $150 billion in 2024. Journalist Danny Funt investigates what's considered one of the most consequential — and least scrutinized — shifts in modern American sports in his new book, "Everybody Loses: The Tumultuous Rise of American Sports Gambling."

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Mar 22 • 9:00 AM EDT • Sports • wfae.org
Third-generation cafeteria owner won't force his 4 sons to take over

Michael Greene, who runs Matthews Cafeteria, shares the highs and lows of managing a family business, and why his kids may not take over one day.

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Mar 22 • 8:55 AM EDT • Business • businessinsider.com
🙂 Positive (50%)
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X

Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…

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Mar 22 • 8:44 AM EDT • Technology • mynintendonews.com
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo

One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening

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Mar 22 • 8:30 AM EDT • Entertainment • pasadenanow.com
‘The Comeback’ took on Hollywood long before ‘The Studio.’ Now, Valerie Cherish will have her curtain call

“The Comeback” was by no means the first series to hold a funhouse mirror up to the entertainment industry, but the comedy starring co-creator Lisa Kudrow, which returns for its final season on Sunday, has certainly always done it in its own navel-gazing yet endearing way.

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Mar 22 • 8:00 AM EDT • Entertainment • cnn.com
Intel compares Core Ultra 200S Plus to Ryzen 9600X and 9700X, gaming uplift stays small

Intel Core Ultra 200S Plus is aimed at creators, not gaming Intel has updated its pre-briefing deck ahead of Core Ultra 200S Plus reviews, and one of the

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Mar 22 • 8:00 AM EDT • Technology • videocardz.com
This floating time crystal breaks Newton’s third law of motion

Scientists have created a new kind of time crystal using sound waves to levitate tiny beads in mid-air. These particles interact in a one-sided, unbalanced way, breaking the usual rules of motion and creating a steady, repeating rhythm. The system is surprisingly simple yet reveals complex physics with big implications. It could help advance quantum computing and deepen our understanding of biological timing systems.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
UF students celebrate ‘women supporting women’ through new mental health group

According to the Healthy Minds Network’s data interface, a little more than one in three female college students suffered from anxiety in 2025, compared to a little under one in four male students.

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Mar 22 • 8:00 AM EDT • Health • alligator.org
In Maine’s marquee Senate primary, Janet Mills reaches out to women by raising Graham Platner’s online past

Janet Mills and her allies are counting on a gender gap to narrow Platner’s wide lead ahead of the June 9 primary to decide who will face incumbent Republican Sen. Susan Collins. They are betting that the unfiltered style that has brought Platner widespread attention as someone who could help Democrats reach young men will backfire with women.

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Mar 22 • 7:00 AM EDT • Politics • cnn.com
Inflatable homes on the Moon? Scientists reveal how humans could live there sooner than expected - Futura-Sciences

How could humans live on the Moon? Although the Artemis program has taken a more cautious approach following recent delays, the goal remains the same: send astronauts back to the lunar surface. Doing so will require systems that allow crews to stay there for several days, or even several weeks....

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Mar 22 • 7:00 AM EDT • Science • futura-sciences.com
We Took Our Three-Year-Old On A Long Haul Flight, And It Was Amazing!

We took our three year old on his first long haul flight in nearly two years. It went so much better than I could have anticipated!

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Mar 22 • 6:50 AM EDT • Technology • onemileatatime.com
4 Things You Never Knew Your PS5 Could Do

The PlayStation 5 lets users create custom button mapping, play from a PC and Mac, use motion control to aim, and amplify sounds with headphones.

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Mar 22 • 6:47 AM EDT • Technology • bgr.com
Give Your Phone a Huge (and Free) Upgrade by Switching to Another Keyboard

Change up the default keyboard in Android and iOS and feel the benefit.

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Mar 22 • 6:30 AM EDT • Technology • wired.com
White House navigates vaccine politics, midterm risks in CDC director search

The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.

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Mar 22 • 6:00 AM EDT • Health • washingtonpost.com
Burcum: UCare collapsed. The Legislature needs to ask why.

"How did UCare, one of Minnesota’s largest health insurers, go from posting record earnings for 2022 to collapsing in 2025?" columnist Jill Burcum writes.

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Mar 22 • 6:00 AM EDT • Health • startribune.com
Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026

Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]

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Mar 22 • 6:00 AM EDT • Sports • sports.yahoo.com
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White House navigates vaccine politics, midterm risks in CDC director search

The Trump administration faces complicated political dynamics as it seeks someone to helm the key public health agency suffering a prolonged leadership vacuum.

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Mar 22 • 6:00 AM EDT • Politics • washingtonpost.com
Umberto Bossi, the League's populist founder and a pivotal figure in Italian politics, dies at 84

ROME — Umberto Bossi, the founder of Italy’s populist Northern League and one of the most influential — and polarizing — figures...

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Mar 22 • 5:57 AM EDT • Politics • post-gazette.com
How investors use the BRRRR strategy to scale real estate portfolios

"My strategy is basically to use every property to fund the next one," said one real estate investor.

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Mar 22 • 5:30 AM EDT • Business • businessinsider.com
Where to watch Oklahoma vs. Michigan State in March Madness Second Round: Time, TV Channel

The No. 4 Oklahoma Sooners face the 5 Michigan State Spartans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 22 • 5:06 AM EDT • Sports • usatoday.com
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AI may be helping more people start their own businesses, but without many employees

The 21-year-old cofounders of one startup said they are bringing in $1 million per month with 13 employees thanks to AI.

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Mar 22 • 5:03 AM EDT • Business • fortune.com
Eating More Ultra-Processed Foods Could Damage Your Bones. Here's Why

Eating higher amounts of ultra-processed foods is associated with lower bone mineral density and a higher risk of hip fractures, even in younger adults under 65.

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Mar 22 • 3:33 AM EDT • Health • healthline.com
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed

A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.

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Mar 22 • 3:16 AM EDT • Sports • spokesman.com
Europe’s trade with Iran: Which countries do the most business with Tehran?

EU–Iran trade fell to its lowest level in two decades in 2025 due to sanctions. Trade continues on a limited scale, with Germany accounting for the largest share.View on euronews

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Mar 22 • 2:00 AM EDT • Business • finance.yahoo.com
One Of Resident Evil's Fundamental Joys Is Watching Beautiful Men Get Hurt

The people love Leon Kennedy for more than his action-game pedigree.

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Mar 22 • 1:00 AM EDT • Technology • gamespot.com
Recap: Sporting KC suffers 4-1 loss to Colorado

Sporting Kansas City suffered a 4-1 loss to the Colorado Rapids on Saturday at Sporting Park. Shapi Suleymanov scored the lone goal for SKC in the defeat as the visitors prevailed behind a brace from Paxten Aaronson to go along with a goal from fellow Designated Player Rafael Navarro and

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Mar 22 • 12:49 AM EDT • Sports • sportingkc.com
New to AI? This 'Master Key' prompt is the only one you need to start

This simple prompt teaches you how to use AI the right way — even if you’re starting from scratch

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Mar 22 • 12:15 AM EDT • Technology • tomsguide.com
OU women's gymnastics senior Faith Torrez scores perfect 10, while Sooners lose in SEC championship

No. 1 OU women’s gymnastics (18-1-1) finished second in the Southeastern Conference Championship against No. 3 Florida (15-2-0), No. 2 LSU (12-5-1) and No. 4 Alabama (9-8-0) Saturday, with the

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Mar 21 • 11:42 PM EDT • Sports • oudaily.com
Families gather at Science Spectrum for Severe Weather Awareness Day

Families and community members gathered at the Science Spectrum on Saturday to learn how to stay one step ahead of weather emergencies.

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Mar 21 • 11:34 PM EDT • Science • kcbd.com
Nebraska survives near-miracle heave at buzzer to advance past Vanderbilt in thriller, keep dream season alive

Nebraska and Vanderbilt put on a show in one of the best games of the NCAA tournament.

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Mar 21 • 11:18 PM EDT • Sports • sports.yahoo.com
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Another Illinois basketball player enters legendary status in NCAA tournament

The Illinois basketball team has had some incredible performances this season, and one player just put up an amazing Round of 32 showing against VCU.

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Mar 21 • 11:08 PM EDT • Sports • sports.yahoo.com
Tottenham Hotspur have chance to turn relegation narrative around against Nottingham Forest

Both sides are barely hovering above the relegation zone, Spurs boasting one point over 18th-place West Ham while Nottingham are only above the drop zone on goal differential

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Mar 21 • 10:34 PM EDT • Sports • cbssports.com
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Chuck Norris's Second Highest-Rated Movie Is One He Spent About 30 Seconds In

The second highest-rated movie associated with Chuck Norris is one he didn't even have a starring role in.

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Mar 21 • 10:16 PM EDT • Entertainment • mensjournal.com
Kings fall 4-1 to Sabres amidst playoff push

The Los Angeles Kings fall short to the Buffalo Sabres in a 4-1 loss Saturday at Crypto.com Arena. Artemi Panarin would score the Kings' lonesome goal, but it was no match for Buffalo's four goals by four different skaters. The Kings stand in the third place Wild Card spot at 28-25-16 and 72 points.

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Mar 21 • 8:25 PM EDT • Sports • sports.yahoo.com
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Healthy Kids Day collaboration with PTO Science Night, April 17

FROM FACEBOOK__Get ready for an action-packed evening! This year, the Bluffton YMCA Healthy Kids Day is joining forces with the Bluffton Schools PTO Science Night for one massive community event!

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Mar 21 • 8:00 PM EDT • Science • blufftonicon.com
Webb Telescope spots “impossible” atmosphere on ancient super Earth

Astronomers have uncovered surprising evidence of a thick atmosphere surrounding TOI-561 b, a scorching, fast-orbiting rocky planet once thought too extreme to hold onto any gas. Using NASA’s James Webb Space Telescope, researchers found the planet is far cooler than expected for a bare rock, hinting at a heat-distributing atmosphere above a churning magma ocean. This strange world—where a year lasts just over 10 hours and one side is locked in eternal daylight—may even be rich in volatile materials, behaving like a “wet lava ball.”

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
Movsar Evloev vs. Lerone Murphy full fight video highlights

Movsar Evloev wins close call against Lerone Murphy at UFC London

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Mar 21 • 7:28 PM EDT • Sports • sports.yahoo.com
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