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U.S. Department of Health and Human Services (HHS) Recommends Science-Based Thresholds to Target Dangerous Enhanced Kratom Products
Kratom products credit: CDPH DEA takes action based on updated recommendation from HHS October 11, 2026 - WASHINGTON - On Friday, the U.S. Department of Health and Human Services relesed the following: The U.S. Department of Health and Human Services (HHS) provided a new recommendation to the Drug Enforcement Administration (DEA) that establishes science-based thresholds for 7-hydroxymitragynine (7-OH) and mitragynine pseudoindoxyl (MGPI), potent opioid compounds associated with products marketed as kratom. The Department of Justice today announced that DEA issued new Notices of Intent reflecting HHS’ updated scientific analysis and recommendations, including a new Notice of Intent for 7-OH and MGPI incorporating HHS’ recommended concentration and ratio thresholds. Following a review of available scientific data and comments, HHS Assistant Secretary for Health Admiral Brian Christine, M.D., recommended that DEA use concentration or ratio-based thresholds to determine which products containing 7-OH and MGPI are subject to Schedule I control for purposes of temporary scheduling of these substances under the Controlled Substances Act. The recommendation is designed to target concentrated or chemically altered products while distinguishing them from natural botanical kratom products, which may contain trace amounts of 7-OH and MGPI. “We are drawing a clear line between natural kratom and dangerous, enhanced opioid products,” said HHS Secretary Robert F. Kennedy, Jr. “We listened to the public, followed the science, and developed a clear recommended threshold for temporary scheduling that targets concentrated 7-OH and MGPI without sweeping natural botanical kratom into Schedule I. The Trump Administration will continue taking decisive action against dangerous products that fuel addiction while making sure our policies are grounded in rigorous science.” Under the recommendation, 7-OH and MGPI would be controlled in Schedule I for purposes of temporary scheduling when either substance alone, or their combined amount when both are present: Exceeds 1 milligram per gram in solid powders, encapsulated material, or other solid forms, or exceeds 1 milligram per milliliter in liquid preparations; or When the mass of mitragynine present divided by the mass of 7-OH, or MGPI, or the combined amount of 7-OH and MGPI if both present, is less than 100. The ratio-based approach reflects the alkaloid composition of natural kratom products and provides a way to identify products intentionally enhanced or concentrated with 7-OH or MGPI. Available scientific data indicate that 7-OH occurs naturally in botanical kratom at relatively low or trace levels, while some evidence reviewed by FDA suggests MGPI may also occur at trace levels in some natural or kratom-derived products. FDA's scientific review found that 7-OH is substantially more potent than morphine in preclinical studies, with available data indicating approximately two to nine times greater potency depending on the study. FDA also identified evidence supporting a meaningful risk of opioid-like physical dependence and withdrawal from MGPI. “Our recommendation gives DEA a scientifically supportable framework to distinguish natural botanical kratom from products that have been concentrated or manipulated to deliver dangerous levels of potent opioid compounds,” said Assistant Secretary for Health Admiral Brian Christine, M.D. “This approach allows us to focus on the products that pose the greatest threat to public health.” In July 2025, following an FDA scientific and medical evaluation, HHS recommended that 7-OH above a specified threshold be placed in Schedule I of the Controlled Substances Act. In July 2026, DEA announced its intent to temporarily schedule 7-OH above a specified threshold, and HHS simultaneously sought public comment on the proposed threshold. DEA subsequently temporarily placed MGPI and two synthetic 7-OH derivatives, MGM-15 and MGM-16, in Schedule I. Since then, questions have emerged about how scheduling could affect natural botanical kratom products potentially containing trace amounts of MGPI. The new HHS recommendation responds to those concerns by providing DEA with a more precise threshold based on both the concentration of 7-OH and MGPI and their relationship to mitragynine, the predominant alkaloid in kratom. HHS and FDA will continue working with DEA to protect Americans from dangerous concentrated and synthetic opioid products while ensuring federal policy is grounded in the best available science. Source: HHS
Wealth Science Advisors LLC Sells 2,311 Shares of Broadcom Inc. $AVGO
Wealth Science Advisors LLC cut its position in Broadcom Inc. (NASDAQ:AVGO - Free Report) by 15.5% in the 3rd quarter, according to its most recent disclosure with the SEC. The fund owned 12,560 shares of the semiconductor manufacturer's stock after selling 2,311 shares during the period. Broadcom m
Beloved ’90s comedian and TV actor dies at 57
Reggie McFadden, the comedian known for “Def Comedy Jam” and “In Living Color,” died at age 57 after living in Tanzania for 18 years.
Sweating the details: Sauna's potential health benefits draw scientists' interest
A group of international researchers is pushing to rigorously study the potential health benefits of sauna and other heat therapies. They hope to bring scientific legitimacy to the age-old practices.
Sweating the details: Sauna's potential health benefits draw scientists' interest
A group of international researchers is pushing to rigorously study the potential health benefits of sauna and other heat therapies. They hope to bring scientific legitimacy to the age-old practices.
Substitute teacher fired over OnlyFans account says business is booming
A Missouri woman says her free speech was violated. Her adult content site has attracted more subscribers after news spread of her dismissal.
Which games are Fox, CBS broadcasting? NFL Week 5 coverage maps
Which NFL games will be broadcast in your region in Week 5? Here are the coverage maps for Sunday's action.
I was almost tricked into sending my résumé to a scammer, red flags
AI-driven job scams are targeting vulnerable job seekers, a former data analyst says. Awareness is the best course of action.
Globo, Endemol Shine Brasil Pact for Global Entertainment Alliance
Brazil’s Globo and Endemol Shine Brasil forge strategic pact to develop and produce non-scripted IP franchises from Brazil or the world.
How John Fetterman spends his time comes under more scrutiny as he weighs future in the Senate
The Pennsylvania Democrat has been labeled an absentee senator for years. As he floats the possibility of running again, what has he actually done?
Memorial Health urges early flu shots before season begins
Memorial Health is encouraging central Illinois residents to get flu shots now as influenza activity begins earlier in some regions.
Cagliari vs Juventus match preview and prediction
Juventus returns to action when they visit Cagliari in Serie A this evening, and it promises to be a tough game for them against one of the trickiest teams in the league. So far, the Bianconeri have d...
Is Jihaad Campbell playing today? Latest update on Eagles linebacker
Jihaad Campbell returned to full practice Friday and has no game designation for the Eagles' Week 5 matchup with the Jaguars
Ndicka and Pellegrini to return to Roma’s line-up
Roma returns to action after the long international break. On Sunday, at 12:30, the Roman team will face Fabregas’ Como at the Sinigaglia stadium. Gasperini will not only be without Cristante, but a...
Particle Engineering and Formulation Science Drive the Next Wave of Drug Delivery
A forthcoming special issue of the Journal of Pharmaceutical Investigation will gather research on how particle engineering and formulation science are transforming drug solubility, dosage form design, and pharmaceutical manufacturing.
Welcome: Sutter Health Park brings Major League ball to Yolo County
On May 15, 2000, a new attraction opened its gates in the east part of Yolo County.
Local businesses bracing for possible storm impacts as Post-Tropical Storm Rachel makes landfall
Businesses in communities like coastal La Jolla spent the day getting ready for possible flooding from Tropical Storm Rachel. NBC 7’s Jeanette Quezada spoke with business owners about the step they’re taking.
Memorial Health System team members take part in AI Summit
Memorial Health System is sharing team members joined professionals from across the Coast for the inaugural Gulf Coast AI Summit. The summit focused on practical learning, collaboration, and the evolving role of artificial intelligence in the workplace and community. Memorial shared they served as a sponsor, team members also contributing as speakers and facilitators. Categories: Local News Tags: AI Summit,...
Reds Bullpen Outlook: Which Relievers Will Return in 2027?
After a dismal season in the divisional basement, Cincinnati faces pivotal contract decisions for veteran arms like Emilio Pagan and Brock Burke to rebuild a struggling bullpen.
Upcoming activities announced at Jervis Library in Rome
Jervis Public Library in Rome has announced its upcoming activities for the week of Oct. 12, including a Halloween glass Cricut crafting event on Wednesday, Oct. 14.
Sad to see clubs can’t run multiple sides
HAVING just read the first round results of local league action it pains me to see that some teams are unable to fulfil their fixtures for whatever reasons. Is this the sign of modern times? People do not want to play or clubs cannot afford to run multiple sides. Back in my days before Leagues, […] The post Sad to see clubs can’t run multiple sides appeared first on The Rugby Paper .
Marrero Hi: To show real political courage, Rep. De La Cruz must sign the Dream and Promise Act
A guest column from Dani Marrero Hi, deputy director of La Unión del Pueblo Entero and LUPE Votes.
Querétaro saw off Atlante and maintained their excellent form
Club Querétaro have gone from being a surprise package to a dominant force in the tournament. Against Atlante, the Gallos Blancos once again demonstrated their tactical solidity, beating the Potros d...
Erie police say mental health may be factor in shooting that killed 9
Erie police are investigating mental health issues as they look for a motive in the mass killing in which a 45-year-old suspected gunman killed nine people, eight of whom were related, before killing himself at a residence on Perry Street on Oct. 9.
Erie police say mental health may be factor in shooting that killed 9
Erie Police Chief Rick Lorah said investigators believe gunman killed six people inside house before killing two women outside and then killing self.
Myles Garrett still unable to practice
Los Angeles Rams DE Myles Garrett still not close to returning
Grading Brandin Podziemski's new five-year contract extension
Instead of waiting, the Golden State Warriors were quick to ink Brandin Podziemski to a five-year contract extension.
Jang Dong-ju Launches Woonsun Entertainment for Actor Management
Jang Dong-ju Launches Woonsun Entertainment for Actor Management Former actor establishes agency focusing on talent discovery, career development, and long-term industry growth
AI is among 17 potentially ‘catastrophic threats’ that researchers say require targeted action
More than a dozen “interconnected catastrophic threats” pose significant risk to global health and wellbeing through the remainder of the 21st century, researchers say – including the potential for extinction. But targeted action from world leaders can help avoid worst-case scenarios.
Bruins’ JJ Peterka Hits Career Milestone In Blowout Win
The Boston Bruins were in action on Saturday afternoon against the rival Philadelphia Flyers, and it was a dominating performance by the host Bruins, who not only defeated the Flyers on the scoresheet but also had a decided advantage in shots.The Bruins earned a 5-1 win, improving their record to 4-2 overall and 3-1 at […] The post Bruins’ JJ Peterka Hits Career Milestone In Blowout Win appeared first on HEAVY.
Maple Leafs Get Telling Sergei Bobrovsky Reaction From William Nylander
As part of their monumental summer of change, the Toronto Maple Leafs brought in multiple new faces, including the likes of Nick Paul and Darren Raddysh from the divisional rival Tampa Bay Lightning, along with goaltender Sergei Bobrovsky, who had played the last seven years with the rival Florida Panthers. Of course, Bobrovsky had helped […] The post Maple Leafs Get Telling Sergei Bobrovsky Reaction From William Nylander appeared first on HEAVY.
Nuclear war and malicious use of AI threaten end of humanity by 2100, says Lancet assessment
Newly established commission identifies 17 catastrophic threats to human health but says ‘realistic route to act’ on each exists
UConn Football Alum to Be Active For First NFL Game
Joe Fagnano is going to get his first shot to be active for an NFL game.
Cigna Group (CI) Could Be 56% Undervalued Following Its Health Sense Rollout
Health Sense rollout and what it could mean for Cigna Group stock Cigna Group (CI) has put its Health Sense platform at the center of a push to link health data, benefits and clinical support into a single experience for oncology and cardiometabolic patients. The model ties together information on medical history, behavioral health, pharmacy coverage, prior interactions and expected costs, then uses that context to tailor outreach and care coordination through existing Cigna Healthcare...
Amanda Seyfried says Meryl Streep is ‘super chill’ to work with — unless you do this one thing
Amanda Seyfried opened up about working with her ‘Mamma Mia!’ costar Meryl Streep, including the one thing that can ‘ruin the vibe’ with the legendary actress.
New Ed Sheeran tour openers revealed after Macklemore controversy
NEW YORK — Ed Sheeran has found a couple of new opening acts for the United States leg of his Loop Tour amid controversy sparked by his ex-opener, Macklemore, who
MillikinWORKS, Decatur Regional Chamber of Commerce to host AI for Business workshops
Sessions will give participants hands-on experience using AI responsibly and practical skills.
O+ Festival in Kingston provides attractions along with healthcare
Uptown Kingston came to life Saturday afternoon with a vibrant blend of art, music and healthcare at the 16th annual O+ Festival.
Vikings Elevate/Activate Multiple Players vs Saints, Including OBJ
The Minnesota Vikings are indeed elevating Odell Beckham Jr. from the practice squad for Sunday's game in New Orleans. See the full list of Week 5 elevations here.
Particle Engineering Takes Center Stage as Drug Formulation Science Enters Its Translational Era
The Journal of Pharmaceutical Investigation has announced a January 2027 special issue on translational advances in pharmaceutical dosage form development, covering particle engineering, solid-state control, QbD, and emerging manufacturing technologies, with submissions due June
Dolphins activate former first-round pick off IR, release QB
The Miami Dolphins are getting back one of their top young defenders this week, after he missed the first four games on injured reserve.
DJ Moore officially questionable for Week 5
Bills WR DJ Moore questionable after a limited practice on Saturday
Mykel Williams is officially back
The Niners have officially activated Mykel Williams to make his season debut.
Lions use final practice squad elevation on veteran safety
The Detroit Lions have used their final practice squad elevation on veteran safety Jalen Mills.
Early-onset Alzheimer's disease shows different warning signs from established risk factors
A study by the University of Oulu and the University of Eastern Finland found that people who developed Alzheimer's disease before the age of 65 accumulated a wide range of health problems, particularly ...
State encourages residents to stay updated on flu, COVID vaccines as virus activity increases
Hawaiʻi Department of Health encourages residents to take common-sense precautions against influenza, COVID-19 and other respiratory viruses as respiratory virus activity increases throughout the state.
Millwall boss Alex Neil reacts to win at Preston
Millwall boss Alex Neil speaks to BBC Radio London after their 1-0 win against Preston.
Erie County Department of Health reports potential diphtheria exposure in West Seneca schools
BUFFALO, N.Y. (WIVB) — The Erie County Department of Health has confirmed a travel-related case of bacterial illness diphtheria, with schools in the West Seneca Central School District being identified as potential exposure sites. According to the district, notifications have been sent to families at Clinton Primary, Northwood Elementary, Winchester-Potters Elementary & East Middle School. […]
REO Town businesses forced to adapt amid economic slowdown
Small businesses in Lansing’s REO Town are adapting to economic challenges by shifting toward experiential services and receiving grants to attract customers, even as some local establishment…
Justin Timberlake, Jessica Biel's son Silas makes acting debut in 'Matchbox'
Justin Timberlake and Jessica Biel's son is ready for his time in the spotlight Silas Randall Timberlake, the 11-year-old son of the "Mirrors" singer, 45, and the "Illusionist" actress, 44,
HTA invites local businesses and community organizations to learn how to reach Hawaiʻi’s visitors
Hawaiʻi farmers, makers, small-business owners, cultural practitioners and nonprofits interested in reaching visitors are invited to register for the Hawaiʻi Tourism Authority’s 2026 Foundational Technical Assistance workshops.
Science-backed tips for improving mental health during World Mental Health Day
Saturday is World Mental Health Day, and psychologist and author Eli Susman joins Good Day Seattle to speak about the positive effects of "Micropractice."
Science-backed tips for improving mental health during World Mental Health Day
Saturday is World Mental Health Day, and psychologist and author Eli Susman joins Good Day Seattle to speak about the positive effects of "Micropractice."
Morrison reacts to defeat by Birmingham City
West Bromwich Albion head coach James Morrison spoke to BBC WM after Saturday's 1-0 defeat by Birmingham City.
Antimatter is leaking out of our Galaxy into intergalactic space, say astronomers | BBC Sky at Night Magazine
Is antimatter leaking out of our Galaxy? Gamma-ray hotspots suggest the Milky Way is making more antimatter than we thought.
Russian Anti-Plague Laboratory Death Raises Questions On Biosafety And Global Health
A number of questions linger after the Russian anti-plague laboratory death. A doctor explains the most important questions that remain that impact public health.
Shai Gilgeous-Alexander Might Have Taken Another Leap
Shai Gilgeous-Alexander doesn't need to add any physical skills. Instead, he and his teammates need to create easier opportunities for high-percentage buckets. Shai playing off ball might accomplish exactly that.
CAR-T vs Stem Cell Transplantation: Where Are Practice and Science Heading in 2026?
CAR-T vs Stem Cell Transplantation: Where Are Practice and Science Heading in 2026? / ALL, allo-HCT, AML, auto-HCT, cancer, CAR-T vs Stem Cell
Pet Spending Is Dropping, and Veterinarians May Need to Rethink Their Business
New AVMA data reveal 89 million dogs, 77 million cats and declining pet spending. Here's what the 2026 trends mean for veterinary practices.
Warriors, Brandin Podziemski reportedly agree to 5-year extension
Podziemski is now under contract with Golden State through at least 2030-31.
Stomach-turning sexually transmitted infection is on the rise — and standard medicines are failing
Shigella bacteria are becoming harder to treat as drug-resistant strains rise, and doctors warn Americans should be concerned but not panicked.
Scientists Discover a Hidden Hydrogen Pathway That Could Transform CO2 Into Valuable Fuel
Scientists have uncovered an unexpected pathway for hydrogen transfer during catalytic CO2 conversion. A computer model designed to predict how carbon dioxide becomes useful chemicals produced a surprising error: It identified formic acid as the main product instead of methanol. When scientists expanded the model to account for thousands of previously overlooked reactions, its predictions
Jaguar reveals a $130,000 all-electric vehicle. Why?
At a darkly lit event in a Manhattan warehouse this week, actress Florence Pugh, Knicks player Karl-Anthony Towns as well as throngs of influencers all gawked at Jaguar Type 01, the British automaker’s first new model in nearly a decade.
World Mental Health Day: 4 Mental Health Tips For Busy Workdays
This World Mental Health Day, discover four practical ways to improve your mental health at work, manage daily stress and make wellbeing a priority.
Arsenal have issues to address despite Guimaraes' rescue act
Heroics and battling performances have already become a theme of Arsenal's season with Bruno Guimaraes coming to the rescue again.
Would ‘money out of politics’ proposal live up to its name?
If approved, Proposal 2 would prohibit direct or indirect contributions to Michigan politicians by DTE Energy, Consumers Energy and companies with more than $250,000 in state government contracts.
Preschool boys favor bigger groups while adults' choices hint at political attitudes
Two cartoon characters appear on a screen. One belongs to a group of three, and the other to a group of two. Which character would you rather play with?
Inter U23 suffer a 2-1 defeat away to Savoia
Inter U23 returned to action after the international break but were beaten 2-1 by Savoia in Torre Annunziata on Matchday 9 of the Serie C season. Vecchi’s side came out on the wrong side of a closel...
Matchday | Timbers back in action Saturday on the road against Sporting Kansas City
The Timbers and Sporting kick off at 5:30pm PT
The Daily Mauling: 10/10/26
Links! The time for tonight’s game has changed to 7pm to beat the storms headed to the southwest This SI article says weather may still be a factor in the game Kansas basketball players give their thoughts on the return of Tre White and Melvin Council, Jr Hall of Famer Mike Ditka died Friday at […]
Care Starts Here: Self-care Strategies for World Mental Health Day
Small, intentional acts of care can support our mental wellbeing, strengthen our resilience and help us be more present.
Apple's All-New Home Hub Will Be Revealed October 13: What to Expect
Apple reportedly plans to unveil an all-new smart home hub as part of the "Welcome home" product launch it announced for Tuesday, October 13. Our image above is just a rough concept based on rumored design details, so be prepared for the device's actual appearance to be different. The device will likely be unveiled in a press release shared on the Apple Newsroom website at around 9 a.m.
Chris Brooks won't play in Week 5
Chris Brooks to be held out of action due to ankle injury
Drake Jokingly Reacts to Bruno Mars Enlisting Karol G for New Video
The 6 god recently joined Karol G as a surprise guest at her Houston tour stop.
🚨 Augsburg-Bayern XIs: Saibari starts; Gnabry on the bench!
Augsburg and Bayern kick off Saturday's Bundesliga action, alongside other matches. The Bavarians want to capitalize on Borussia Dortmund's slip-up after they drew with Werder Bremen on Friday despite...
‘Primetime’ reveals the story behind ‘To Catch a Predator’
Lance Oppenheim’s A24 film goes behind the scenes of the sting house. FSU and TSC students react to Robert Pattinson’s Chris Hansen.
LeBron James is everything Philadelphia wants. And everything it can’t stand
The city has embraced its new superstar with open arms, even as he choppers in from Manhattan and makes no secret of the fact that Philadelphia was never his first choice
12 reactions · 3 comments | A politician allegedly killed for...
A politician allegedly killed for promoting health measures in the fight against Ebola. Health workers attacked, medical facilities put on fire. What's behind people's anger in response to aid in the...
Rudy Matondo set for Paris FC contract extension
Rudy Matondo (18) is expected to sign a contract extension with Paris FC shortly, according to information from L’Équipe.The midfielder, currently under contract with Les Parisiens until 2028, is l...
There Has Never Been a Better Time To Get Into Star Wars
Two great games have helped me see the light
KJ Apa talks finding Jimmy Stewart’s voice, recreating classic ‘It’s a Wonderful Life’ scene
KJ Apa talked to Entertainment Weekly about the new biopic ‘Jimmy,’ in which he plays Oscar-winning actor James Stewart, known for his distinctive voice and the all-time Christmas classic ‘It’s a Wonderful Life.’
Blood proteins may offer new clues to gut health in coeliac disease
Coeliac disease is an autoimmune condition in which the immune system reacts adversely to gluten. Eating gluten causes inflammation in the gut, which can damage the intestine and impair its ability to absorb nutrients.
According to Science, People Who Use Emojis in Texts Have Higher Emotional Intelligence
You probably do it without thinking. A thumbs-up after confirming dinner plans, a laughing face to soften a sarcastic remark, a heart slipped into a goodnight message. Emojis have become so woven into the way we text that most of us never stop to wonder what those tiny icons actually say about us. But researchers...
6 Hobbies That Can Become Startup Ideas, From Photography to Travel
Your next business may be hiding in what you already do for fun. These hobbies can produce practical startup ideas with growing markets.
Chelsea announce Cole Palmer has signed new contract
Attacking midfielder is rewarded for a positive start to the season
🚨 Official: Chelsea extend key player's contract until 2034!
Another contract extension at Chelsea!At midday on Saturday, Cole Palmer extended his Chelsea contract by another season. The English forward is now tied to the London club until the summer of 2034. A...
F1 Singapore GP: Verstappen, Other Drivers React To Sprint Qualifying
Max Verstappen and his fellow Formula 1 drivers give their immediate reactions to Sprint Qualifying in Singapore.
Sergio Pérez Blames Bottoming Out for Singapore GP Qualifying Crash
The Mexican driver lost control of his Cadillac on turn 4 after a heavy compression into the asphalt. The impact damaged his front wing and caused the red flag. He finished twentieth but is confident he can improve his race pace.
The economic impact of the Chicago Marathon
Runners aren’t the only ones going the distance on Sunday. For local businesses, the marathon crowds offer a chance to put their best foot forward.
Tolu Arokodare To Start: Ajax Predicted XI Against NEC Nijmegen
After a lengthy international break, Ajax return to action on Saturday night against NEC Nijmegen.
Darline Graham opposes Chinese manufacturing. Her husband’s employers rely on it.
The senator and sister of the late Lindsey Graham has said the U.S. must “stop depending on Communist China for things America can make ourselves.”
Andoni Iraola hints at Liverpool striker gamble for Man City
Andoni Iraola has hinted that he may look to Bradley Barcola to act as an auxiliary striker in the absence of Alexander Isak.The Sweden international was missing from the club’s training sessions in...