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'It was just a solution!' – Ronald Araujo opens up on famous header tackle and Liverpool growth
Liverpool defender Ronald Araujo believes the team can still raise their performance levels despite winning five consecutive matches in all competitions. The Uruguayan also reflected on his famous header tackle against Brighton ahead of Sunday's clash with Premier League champions Arsenal.
Brandy Lefsyk to blend science and holistic wellness in November
TOWNSEND — Imagine settling into a quiet room, letting the stresses of the day fall away as soothing sounds and gentle vibrations create space for stillness and reflection.
High street ‘slot farms’ could evade budget tax rise through bingo hall loophole
Hundreds of adult gaming centres in England have bingo licences that still qualify them for discounted business rates
Smart Tools, Real Voices: Why Authenticity Still Wins in Healthcare Marketing - Florida Hospital News and Healthcare Report
By Dorron Marketing Artificial intelligence has arrived in healthcare marketing, and it is not going away. From drafting social posts in seconds to segmenting patient audiences, personalizing email campaigns, and […]
Business Owners Have a Window. Most Aren't Ready to Use It. by Tully Ryan
I spend my working life on both sides of a business sale. As an M&A advisor based in Wilmington, I help lower middle market owners across North Carolina, South Carolina and Virginia sell what they've built. As the founder and CEO of IQExit, I work with the bankers, wealth advisors, CPAs and attorneys who sit beside those owners for years before a sale ever comes up. From both seats, I keep seeing the same thing. The market is ready for our owners. Too many of our owners aren't ready for the market. Start with our own backyard. Wilmington's metro area added more than 12,000 residents between July 2024 and July 2025, a 2.6% jump that ranked seventh in the country. It also posted the highest job growth rate of any metro in North Carolina. I see the same pattern in the growth markets I work in across the Southeast. New residents mean new customers and new workers. They also mean new buyers: people who moved here from corporate jobs and want to own something, private equity groups looking for add-ons in HVAC, electrical, landscaping and other trade services, and younger entrepreneurs who would rather buy a running business than start one from scratch. The ownership numbers are hard to ignore. About half of North Carolina's small businesses have an owner who is 55 or older, and roughly 85% of those owners have no succession plan, according to the North Carolina Employee Ownership Center. Nationally, more than half of Baby Boomer business owners have no documented transition plan. That isn't a crisis yet. It's a timing problem. A lot of businesses will change hands over the next decade, and the prepared ones will get the better buyers and the better terms. Buyers have money and they're using it. But an active market doesn't mean a fast one. The IBBA's latest Market Pulse survey found that Main Street deals took six to 10 months from engagement to close in the second quarter, and lower middle market deals took 11 to 12 months. That clock starts after the owner decides to sell. In my experience, the real preparation has to start years before. Two clocks, two playbooks When I sit down with an owner or their advisor, my first question isn't “What's it worth?” It's “When?” The answer puts the owner in one of two groups. If the owner wants out within 24 months, we're in execution mode. There's no time to rebuild the business. The work is cleaning up what a buyer will test: three years of financials that tie to the tax returns, an add-back schedule you can prove, customer and vendor contracts in writing, a lease that can be assigned, and a price the market will actually pay. The goal is certainty to close. If the exit is two to five years away, the owner has something worth more than time. They have choices. That window is where most value gets built, and most owners waste it by waiting. What kills deals In the lower middle market, deals rarely die over the headline price. They die in diligence, or they get retraded late in the process. I see the same causes again and again. The owner is the business. If every key customer relationship runs through the owner's cell phone, a buyer sees risk and a lender sees more of it. The books don't hold up. Buyers spot weak accounting fast. Statements that get revised mid-process, a revolving door in the bookkeeper's chair, revenue tracked on a side spreadsheet, and margins that slip while sales climb with no clear reason all make a buyer nervous. So does an owner who pushes back when asked for documents. And plenty of private owners run personal expenses through the company. Add-backs are normal. Add-backs you can't document turn into a lower offer. The real estate isn't sorted out. Many owners hold their building in a separate LLC. That's fine, but the lease terms or the property sale should be settled before a buyer shows up, not halfway through diligence. Revenue sits in too few hands. Picture a contractor with 40% of its work coming from one builder, or a service company running on handshake deals. Buyers will still look, but the terms shift toward more seller financing, an earnout, or less cash at closing. Owners and advisors: if your exit is three to five years out • Get a baseline now. Find out where the business really stands today: what a buyer would pay, who that buyer is likely to be, and which gaps would hurt you in diligence. You can't fix what you haven't measured, and the answer is often different from what the owner expects. • Make yourself less necessary. Spend the next few years building a manager or small team that can run daily operations and own customer relationships. Put handshake deals into written contracts. A business that runs without its owner is worth more and is far easier to finance. • Clean the books for three straight years. Buyers and lenders look back at least three years. Separate personal expenses, keep the financials tied to the tax returns, track every add-back as you go, and settle the real estate plan early. A word to CPAs CPAs often see a sale coming before anyone else, and you're usually the most trusted voice an owner has. Year-end meetings are the right time to start this conversation. Here's what I'd ask every CPA to do this season with business owner clients over 55: • Ask the timing question. “Do you see yourself owning this business in five years? If not, who takes it over?” Write down the answer and bring it up again at next year's meeting. • Run a proof of cash and review revenue recognition. Make sure the cash in the bank ties to the revenue on the books. Pay close attention to contractors with work in progress and to companies selling memberships or service plans. These issues are easy to fix with years of lead time and painful to fix a month before closing. • Pair the tax return with an exit readiness review. Invite clients to complete IQExit's Exit Readiness Intelligence (ERI) process as part of year-end planning. It gives you and the client a shared picture of readiness gaps and an indicative value range, and the results come back to you as the advisor. That turns a tax meeting into a planning relationship, and it puts you in position to bring in tax and M&A help early, when choices like purchase price allocation can still save the client real money. Changing the conversation For bankers, wealth advisors and attorneys, the hard part is raising the subject without seeming to nudge a client toward the door. I understand that. Nobody wants to tell a 60-year-old owner it's time to sell. So don't. Ask a different question: “If a buyer called tomorrow, what would they find?” That's a planning question, not a pitch, and it's useful whether the exit is two years out or 15. It's the question we built IQExit to help advisors answer. Whether you're in Wilmington, Raleigh, Charleston, Richmond or anywhere else, owners have a real opening right now. The buyers are out there and so is the capital. The owners who come out ahead will be the ones who start getting ready before they're ready to sell.
The Best Time to Fix Your Business Is When Things Are Going Well by Nathan Tayloe
There's a pattern I've noticed working with growing businesses over the years. Conversations about what needs to change rarely happen when things are going well. They tend to happen when growth slows, a competitor starts winning business, or something that used to work stops producing the same results. By then, the decisions are often harder, more expensive, and more urgent than they needed to be. It's understandable. When revenue is growing, customers are coming in, and employees are busy, there's little incentive to question what's working. Leaders have plenty to manage without creating new challenges for themselves. Running my own business has taught me that it's easy to get caught up in what's happening today and put off improvements you know will matter tomorrow. Those periods of success may actually be the best opportunity a business has to make meaningful improvements. When Success Makes Change Less Urgent Most businesses have things they know could be better. The challenge is finding a compelling reason to address them when everything appears to be working. Maybe the company has outgrown its original positioning. Perhaps internal processes haven't kept pace with growth, or the customer experience has become inconsistent as the organization has expanded. These issues don't necessarily prevent a business from growing. Strong demand can make them easier to overlook, especially when teams are focused on keeping up with the work already coming in. Over time, small inefficiencies become accepted ways of operating. Outdated processes remain in place because they've always worked well enough, and opportunities to improve get pushed aside in favor of more immediate demands. The business continues moving forward, but some of the things supporting that growth aren't getting stronger along with it. The Advantage of Acting Early When a business is performing well, leadership has something valuable: options. There's more flexibility to invest, experiment, develop people, and make thoughtful decisions without the pressure of an immediate problem that needs solving. Compare that with trying to make the same changes when revenue is declining, or the market has shifted. Investments become harder to justify, timelines get compressed, and decisions that could have been made strategically become urgent responses to circumstances. I've seen businesses postpone improvements for years because there was never a particularly good time to address them. Eventually, circumstances decide for them, often when they have fewer resources and less flexibility to respond. Growth Changes What a Business Needs This is especially relevant in a growing market like Wilmington, where new businesses, new residents, and continued investment are creating opportunities across the region. As organizations grow, the expectations placed on them change. Customers expect greater consistency, employees need clearer processes and opportunities, and leadership has to make decisions that support a larger, more complex business. What worked when a company was smaller may still work today, but that doesn't necessarily mean it will support where the organization wants to go next. Sometimes the most valuable improvements are the ones that prepare a business for demands it hasn't experienced yet. That might mean: Strengthening internal processes before they become bottlenecks Developing leaders before the organization depends on them Improving the customer experience before inconsistencies affect retention Revisiting positioning before the market outgrows the company's story None of these changes requires a crisis. They require recognizing that a growing business needs to keep evolving, even when current performance gives leadership little reason to worry. Use the Good Years Wisely Successful businesses don't need to constantly reinvent themselves. There's value in knowing what works and having the discipline to build on it. There's also value in occasionally asking whether the business is as strong as its current performance suggests. Are there problems we've learned to work around instead of solving? Are we still operating the way we did several years ago, even though the business has changed? What would we improve today if we weren't waiting for something to go wrong? Success creates the freedom to ask those questions and act on the answers. The businesses that make the most of that opportunity are often better prepared for whatever comes next. The strongest businesses don't need a crisis to recognize an opportunity to improve. They use the good years to prepare for the years ahead. — Learn more about how we help organizations strengthen their positioning, align their strategy, and prepare for what's next at tayloegray.com, or reach out directly at nathan@tayloegray.com.
Halloween celebrants decked out for fun, rain or shine
On Saturday, Oct,. 31, Los Angeles County, it was actually still a mystery if candy seekers would get soaked that evening.
$10,000 in Vanguard's Health Care ETF in 2004 Grew to $93,915, and It Still Charges 0.09%
A single health care ETF launched two decades ago at rock-bottom cost has quietly compounded into a sum that surprises most investors, but whether its three closest rivals can match it depends entirely on what kind of risk you are willing to carry.
Did you remember the 2026 Arizona Diamondbacks?
Three weeks ago, we asked if you were able to name all the players who took the field for the 2026 Diamondbacks. If you missed that, here’s your chance: you still have a chance to take the test before your eyes stray down to the rest of the article. The rest of us will wait […]
Reacts Survey Results: The Jaguars (Still) Need Pass Rush Depth
Jacksonville has 10 more days to bring in defensive reinforcements before the 2026 NFL trade deadline.
Bitcoin's white paper turns 18, and small businesses are still paying for the bailouts it answered
Eighteen years after Satoshi published the Bitcoin white paper, business owners are still covering the cost of a system built on bailouts, and they can protect part of their surplus by keeping it in bitcoin, argues Onramp CEO Michael Tanguma.
After living through century of American politics, Florida’s oldest voters aren’t done yet
In interviews across Florida, centenarians said they are as divided politically as the rest of America. They see today’s political races as increasingly bleak and divisive. Still, they have not given up on voting.
Beyond QR Payments: The Politics of Economic Mobility in the Global South
A market vendor in Indonesia can spend an entire day receiving QR payments and still struggle to obtain a bank loan.
Ward and Smith: Tariff Refunds
••• SPONSORED SECTION ••• TARIFF REFUNDS: What Your Business Could Still Recover by Kelly Reid In February 2026, the Supreme Court ruled that the International Emergency Economic Powers Act (IEEPA) did not authorize the President to impose tariffs. That decision opened the door to refunds of IEEPA duties, including the broad “reciprocal” tariffs introduced in […]
Politics, punditry, and parenthood: Living life and through country music
To this day, I still prefer cold Coke to white wine. And as far as music is concerned, I have fallen deeply in love with the country song, which some would say is even less refined than pop.
Is American Electric Power Still The Business You Bought?
For questions about this article or underlying research, email help@trefis.com. Most people who own American Electric Power (AEP) bought a steady electric utility for its dividend, which came to 2.9% of the company's market value over the last twelve months.
Dolores Huerta Taught a Generation How to Organize
Rest in power, Dolores Huerta. She faced down growers, organized the fields, won farmworkers protections most states still deny them, and gave the whole Left a rallying cry we’ll be shouting for gener...
Misericordia opens LEAP Center, uniting exercise science labs with athlete training
FOX56 WOLF TV carries news, sports, weather and coverage of local events in the Wilkes-Barre, Pennsylvania area, including Mountain Top, Plymouth, Nanticoke, Kingston, Back Mountain, Scranton, Moosic, Pittston, Avoca, Edwardsville, Hilldale, Wyoming, Laflin, Yatesville, Pittston, Dupont, Sugar Notch, Korn Krest, Warrior Run and Larksville.
4 Unsung Heroes for Illinois Football This Season
Illinois football is still in the hunt for a prime bowl game, and these players are a big reason why.
Drake Equation: The "Second Most-Famous Equation In Science" Turns 65 This Week. Is It Still Relevant Today?
Meant as a back-of-the-envelope calculation, it has gone on to become perhaps the second most famous equation in physics.
Florida education chief defends science plan
Education Commissioner Henry Mack pushed back Tuesday against criticism that Florida is de-emphasizing evolution in its new plan for teaching science, insisting the state is still covering a subject he agreed was a bedrock of biological science.“Evolutionary biology and the theory of evolution is in the standards,” Mack said. But several parents and teachers who attended an evening forum on the state’s proposed science standards criticized the proposal by the Florida Department of Education, which Mack runs, specifically the handling of evolutionary science.Joshua Garrett, a teacher in Orange County Public Schools, said the state’s proposed standards “danced around” evolution.State standards are benchmarks for what students should learn in their classes kindergarten through 12th grade, guiding what lessons are taught, what subjects are in state-approved textbooks and what concepts are tested on state exams.Florida’s current science standards call evolution a “big idea” and “the fundamental concept underlying all of biology.”The proposed ones barely mention evolution — a scientific theory explaining change in living species over time from natural selection that has been a cornerstone of biology for more than a century. The term “evolution,” in fact, is never defined in the new high school life sciences standards, though the concepts are sprinkled across several units.The education department has made revisions to its proposal, officials said, but it was not immediately clear at the Tuesday forum, held at Lake Buena Vista High School in southwest Orange County, what those changes were.Mack interjected during Garrett’s comments asking him where specifically he wanted the state to mention evolution more prominently. Then he said, “Consider it done.”Mack also asked Garrett to join the state’s faculty committee on the standards.The state released the new standards in September, and several experts quickly criticized them, saying they lacked depth and skirted around both evolution and climate change, important topics for Florida students to learn.The state has since hosted a “listening tour,” including a virtual forum and two other in-person meetings in Walton and Hillsborough counties. Tuesday’s meeting drew a small crowd of about 30 people, six of whom spoke.Mack described the state’s public forums as a chance for “myth busting” and to make clear Florida’s position.He wants to students to learn “above ideology,” he said, and added that evolution isn’t settled science. TNCMS.AdManager.render({region: 'fixed-big-ad-middle-asset', slot: 1, fold: "span"}); “I want to cultivate skeptics in the healthy sense of that term. As a result of these standards, students should not be walking away convinced of anything other than the rigor of the scientific method,” Mack said.The new standards would replace the current set, adopted after a monthslong, statewide fight over the inclusion of evolution as a required subject of study. Those who opposed the 2008 standards argued creationism, or the biblical story that God created all living things, should be taught alongside evolution.Thomas Simon, a Winter Park parent, compared Florida adopting the new standards to Nazi Germany ignoring the findings of Jewish scientists — which in part lost them World War II.“If this board could explicitly name communism in the history standards last year — because words matter — you must explicitly name the foundations of modern medicine, agriculture, and energy,” Simon said.Florida last year adopted new standards that require students learn about the “dangers and evil of communism.”Teri O’Connor, an elementary science teacher in Orange County, urged Mack to curtail the total number of standards, as they list more than 1,000 benchmarks teachers are to cover during their classes.“It’s only 180 days of school. That right there is an issue, especially if you want to dive in. If we need to teach the rigor of it and to critically think about each one, that’s difficult,” she said.Kathleen Murray, who spoke on behalf of the conservative political group Citizens Defending Freedom, said she was in “strong support” of the proposed standards. Science should teach children how to think, not what to think, she said.“When teaching the origins of life and the universe, the curriculum owes it to the Florida students to be honest about the limits of what scientific models can actually prove,” Murray said.State education officials said they’d received about 1,800 comments on the benchmarks, and they have updated them based on that criticism.With Tuesday the state’s final scheduled public forum, Mack said his biggest takeaway was that the standards needed to be more explicit about teaching students how to evaluate scientific studies and evidence and how to understand the scientific method.“We might have to do a better job of helping students question more as a result of these standards,” he said.In his original statement when the standards were announced in September, Mack wrote in a social media post that “science begins in wonder, not in ideology,” and “the classical tradition taught that nature is intelligible because it is ordered — that the book of creation can be read by reason.”Some read that to mean he was trying to interject religion into public school education. 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Scientists think our recent ancestors may have run hotter -- but why?
150 years ago, average human body temperatures appear to have been higher than now. Scientists are still exploring exactly why.
Udinese vs. Roma probable line-ups and where to watch
Donyell Malen leads the line for Roma as Gian Piero Gasperini’s side visit Udinese, with Paulo Dybala still out. Nicolò Zaniolo faces his former club for the Bianconeri.It kicks off at 18:00 CET [1...
Local voters and political analysts predict busy last day of early voting
PORTSMOUTH, Va. (WAVY) — Are you still searching for Halloween plans? Well, how about handling your civic duty? If you haven’t cast your ballot for the upcoming election, you still have a cha…
Denver Broncos Announce Jaylen Waddle Injury Update Before Chiefs Game
Jaylen Waddle returned to practice this week, but the Broncos still have an important offensive question to settle before facing the Chiefs. The post Denver Broncos Announce Jaylen Waddle Injury Update Before Chiefs Game appeared first on HEAVY.
Arkade is a PC Peripheral That Transforms Every Modern Shooter Into a Light Gun Game
Arkade is a PC Peripheral That Transforms Every Modern Shooter Into a Light Gun Game
Jets Get Blunt Garrett Wilson Update Amid 49ers Trade Speculation
Although the Nov. 10 trade deadline is still days away, the San Francisco 49ers have started making their moves to bolster the team for the second half of the 2026 season. The Niners have already made one move by trading for DeForest Buckner to beef up their defensive line.San Francisco sent a 2027 fourth-round draft […] The post Jets Get Blunt Garrett Wilson Update Amid 49ers Trade Speculation appeared first on HEAVY.
First Nintendo Switch 2 emulator for PC is out, and it already boots Mario Kart World
Switch 2 emulator Eden-NX2 went public on October 29, booting Mario Kart World and Donkey Kong Bananza on Windows PCs, though performance is still rough.
Join Overtime to talk south Georgia ball with WALB Sports
With an action-packed week in SGA high school football, there is still so much to talk about in Locker Room Report Overtime.
Bill Belichick and Jordon Hudson reportedly broke up in secret last year, but still 'committed to their business partnerships'
One of the most scrutinized romances in sports is reportedly over.
Bill Belichick and Jordon Hudson reportedly broke up in secret last year, but still 'committed to their business partnerships'
One of the most scrutinized romances in sports is reportedly over.
Unsolved: Amarillo police seek tips in 2003 Halloween killing of local business owner
More than two decades after an Amarillo business owner was shot and killed inside his home on Halloween night, investigators say they still do not have a clear motive or a suspect in the case.
Celtics Make 2 Contract Moves Before Looming Deadline
The Boston Celtics are still pointing toward the future, and made two decisions on young players Friday just before a key deadline. The post Celtics Make 2 Contract Moves Before Looming Deadline appeared first on HEAVY.
EAST TEXAS POLITICS: Special midterm preview with party chairs, data analyst and youth leaders
This week’s edition of East Texas Politics on East Texas Now is a special midterm elections preview. Smith County Republican Party Chair David Stein and Smith County Democratic Party Chair Kristen Hardin-Sigler are among the guests on this week’s show.
Bill Belichick and Jordon Hudson reportedly broke up in late 2025, but still 'committed to their business partnerships'
One of the most-scrutinized romances in sports is reportedly over.
Bill Belichick and Jordon Hudson reportedly broke up in late 2025, but still 'committed to their business partnerships'
One of the most-scrutinized romances in sports is reportedly over.
Yankees should revisit Shea Langeliers trade with a strict limit
The Yankees have already learned that asking about Shea Langeliers and actually getting him are different things. They should still […]
Despite concerns, the Trump administration still sends pregnant migrant minors to south Texas
Several children have had to leave the state to receive medical care, including abortions, that is unavailable in Texas.
I Completed Big Walk's Final, Best-Hidden Secret Puzzle
I still don't know what you call them
Paramount+ Acquires Rights to 'Blippi' and 'CoComelon' Series
Paramount+ has acquired rights to Moonbug Entertainment shows including series from the 'Blippi' and 'CoComelon' universes.
Sanford Health does “Backwards Halloween”
Halloween can look a little different for kids spending the holiday in the hospital, but staff at Sanford Health in Bismarck are making sure their little patients still get to celebrate.
Examining Anthony Davis’ Legacy In New Orleans
Lost in Washington, Anthony Davis still has not signed an extension with the Washington Wizards and is trying to reinvigorate his career in Washington after a down year in Dallas. However, in his early years, he lived through various stages as a player in New Orleans. As Harvey Dent said in the Nolan Batman trilogy, …
Local business confidence concerns have eased compared with 2025, index shows
Southern Nevada business leaders are still feeling uncertain about the economy’s future, but fears have eased when it comes to hiring, sales and profits, according to a new report.
The Guardian view on 50 years of The Selfish Gene: flawed, outdated, yet still a model of truly popular science writing
Editorial: Richard Dawkins’ first work has thrilled fans and frustrated critics for five decades. The science has moved on, but any writer looking to supplant its place must learn its lessons
The Bolsonaro clan is still strong in Brazilian politics despite Flávio's defeat and flight to U.S.
Flávio Bolsonaro has left Brazil for the United States after losing the presidential runoff
Why human scientists, not AI, still control the fate of biosecurity
AI models have written the genome of a working virus for the first time, though the ones that came alive attack only harmless lab bacteria
Can Stanford's Freshmen Handle the Jump to ACC Basketball?
Julius Price and Aziz Olajuwon have already shown flashes of their potential. The other three freshmen are still working to establish their roles
‘Business is booming, and jobs are still being cut’: Ursula warns workers as Amazon’s record margin follows more layoffs
Amazon cut about 250 more jobs this week, then reported its highest operating margin ever.
Home health aide arrested for allegedly killing elderly Queens woman, police sources say
Federal financial assistance now available to businesses impacted by BWCAW closures and wildfires
Several months after closures in the Boundary Waters Canoe Area Wilderness and surrounding wildfire impacts disrupted businesses across northeastern Minnesota, some are still dealing with the summer’s financial fallout. This week, Cook County officials announced that small businesses and nonprofit organizations that experienced financial impacts can now access federal financial assistance through the U.S. Small...
Science Begins With Wonder and Sometimes With a Salamander.
The Bar Harbor Story is generously sponsored by the Don & Beth Straus Center at Birch Bay Village. BAR HARBOR—The children had come to see the axolotls, those odd little salamanders with pink frills around their heads and the remarkable ability to grow back what they lose. But also there were stickers. There were crafts. There was the kind of excitement that makes a roomful of kindergarteners forget, for a little while, that sitting still is ever a requirement. And then there were the animals themselves, alive in their clear cases at the MDI Biological Laboratory, where 12 children from Pemetic Elementary School got to meet the creatures they had been learning about in class. “Do you love them?” their teacher, Carol Null, asked. The answer came back in a chorus. “I do!” “I do!” “I do too,” Null said, smiling. “I love them even more now.” That was the thing about a day at the lab. Science was no longer a picture in a book, or a word on a classroom wall. It had a face, a tail, and a set of extraordinary powers. And for a child, sometimes that is where wonder begins. Sometimes learning about science is about stickers. Sometimes it’s about bright pink feathers and getting super excited about that glow in the dark. Sometimes learning about science is joy—pure and simple joy. That’s how it was October 28 at the MDI Bio Lab as Miss Hannah (known in the lab as Dr. Hannah Lust, director of STEM, undergraduate and graduate Training), other scientists, graduate students, and MDI Bio Lab staff, hosted 12 students from Carol Null’s Pemetic Elementary School’s kindergarten class. The 2.5-hour program created by Dr. Lust focused on axolotls, a species of mole salamanders, a superhero in the animal world: a superhero with some scientific-study worthy superpowers. One of those superpowers come from the axolotls’ ability to regenerate body parts, including entire limbs. But also, they’re cute. This fall, before coming to the internationally renowned lab nestled in Salsbury Cove, Null has been integrating axolotls into her class. They’ve been part of the kids’ vocabulary and their storytelling. They’ve been part of science. They’ve been part of the children’s learning about facts vs opinions. The Pemetic Elementary kindergarten students learn about invasive species and the impact on the ecology and one student related it to their dad, who lobsters, and his worries about green craps, an invasive species in Maine. “Are they bigger or smaller than you thought they’d be?” the children are asked after the scientists show them multiple see-through cases of axolotls, lined up on a table that they’re told not to jiggle. “Bigger!” “I think they’re bigger.” “Smaller!” The bio lab opening its doors to the collaborations and to students and families is a norm, but this is the first program of this kind. It’s meant to encourage kindergarten students about axolotls. But when the students come to the bio lab something else happens too—something beyond Null’s child-focused teaching—the students see science—and the regenerating creatures in real life. They do crafts. They speak with them. They meet people who know all about them: scientists and educators who talk to the kids like they’re equals. That’s a superhero power, too. Null speaks about meeting the kids where they’re at in her classroom, letting their interest and hearts lead her in their learning. That requires recognition of interests, of individuality, of empathy. Some would argue that’s a super power, too, but it’s also in those 12 students as they listen to the storybook, encounter those live axolotls, and hear about how axolotls might help advance society’s understanding of human health. As Eddie Seckeler (comparative animal models, CORE facility manager), carefully puts the axolotls on a cart and rolls them away, some of the children stop what they’re doing to watch. “Bye axolotls.” “Bye!” “Bye!” The axolotls are not just images in a book, Hello, I’m an axolotl by Hayley and John Rocco; they are real and cool. MDI Biological Laboratory scientists Dr. Prayag Murawala and Dr. James Godwin who both feature in the Roccos’ book. The kindergarteners get to meet them in real life, off the page, in the world, doing science. They learn from them, laugh with them. “The visit is about more than meeting an unusual animal. By introducing children to scientists working in their own community, the experience helps make science tangible and accessible. Students can see that science is not just something they read about in books or learn about at school. It is something real people do every day by asking questions, making observations and working to understand how the world works,” explains MDI Biological Laboratory Director of Communications Rebecca Woods. While the students make axolotl-related crafts around tables, graduate students and staff help out. Ryan holds up his construction paper setting and axolotl to show Omar Maged, a graduate student. “Do you like it?” Ryan asks, eyes wide, turning from his axolotl to look up at Omar. Omar studies the construction paper for a moment, smiles and says definitively, each word important. “It is beautiful.” Null says that she’s so thankful for all the “amazing” community partners that her school and her students get to interact with as they learn and grow and live, but emphasized how the MDI Bio Lab goes out of its way to create something meaningful, something that allows her young students to build their own agency, to know that they can be impactful in their community, to show them how how things they learn about in text is connected to themselves and their community. Woods explains, “Axolotls have an extraordinary ability to regenerate, or regrow, certain body parts, including limbs. Scientists study these animals to understand how regeneration works and what their biology might teach us about tissue repair and healing in humans.” The children enter the space for “a memorable introduction to a big scientific question,” Woods said. “How can some animals regrow body parts? The encounter encourages children to look closely, wonder about what they see and begin to understand how scientists use observations and experiments to investigate questions.” “For the students, the visit is an opportunity to explore a fascinating animal and meet scientists in their own community,” Woods explains. “For MDI Biological Laboratory, it is a chance to share the excitement of research, nurture curiosity, and help young learners discover that science begins with asking questions.“ At the beginning of the school year, Pemetic kindergarteners didn’t know what the axolotl was—at least not exactly—now they know all about the axolotl’s life cycle. “It’s different than a butterfly,” one student told Mrs. Null. It is. The change and knowledge might seem small**,** but it offers a glimpse of what happens when a subject moves beyond the pages of a book and into a child’s world. The children have been learning about butterflies at the Charlotte Rhoades Park and Butterfly Garden. At both the garden and the MDI Bio Lab, the children see the animals, meet the scientists who study them and at the lab encounter a question that researchers are still working to answer: how can some creatures regenerate body parts, and what might that teach us about healing in humans? They leave with gift bags, paper-plate salamanders, new things to wonder about and a connection between the science they learn in school and the work happening in their own community. The axolotls may be remarkable for their ability to grow back what they have lost. For these young students, the day offers something different: a chance to discover how much there is to ask, observe, and imagine. When Null’s students had time to use chalk and draw whatever they want, in the beginning of the year, they drew rainbows. Now? They’re using that chalk and choosing to draw axolotls instead. About MDI Bio Laboratory For more than 125 years, MDI Bio Lab has been a center for training and research in comparative biology. In the last two decades its biomedical research has focused on aging, regeneration, and environmental toxins. The Laboratory houses 11 research groups staffed by an international team of world-class scientists and graduate students. It also leads a statewide network of colleges, universities and research institutions that collaborate to provide training, research experiences and financial support to help young Mainers play a bigger role in today’s biomedical revolution. Located on Maine’s rugged coast, the Laboratory’s 100+ acre campus houses research facilities, cottages and dorms that house visiting scientists and students. It is also home to MDI Bioscience, a subsidiary working to design innovative techniques to speed the drug discovery process. The Bar Harbor Story is generously sponsored by Rick Osann Art. LINKS TO LEARN MORE NIH INBRE MDI BIOLOGICAL LABORATORY Pemetic Elementary School Hello, I’m an Axolotl Photos: Carrie Jones/Bar Harbor Story HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment
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Solid demand continued, but consumers still seemed stretched this past cycle. With 2027 on the horizon, there was high uncertainty among businesses about growth, geopolitics, and interest rates.
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Zelda 40th Anniversary Switch 2 restock update: the Nintendo Store remains your best bet
🎮 The Zelda 40th anniversary Switch 2 was released on October 29 and flashed in and out of stock at the Nintendo Store 🚨 Our Zelda Switch 2 restock tracker @mattswider on X will send out an alert as soon as stock appears 👀 Walmart was our top pick to have a restock, but a supply chain delay has pushed the date back ⌚ In-store midnight launches are being held at GameStop, Best Buy, and Nintendo New York/San Francisco Walmart: Zelda Switch 2 console Best Buy: Zelda Switch 2 console GameStop: Zelda Switch 2 console Nintendo: Zelda Switch 2 console 🚨 We’re tracking Zelda Switch 2 stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 The Legend of Zelda 40th Anniversary Switch 2 launched yesterday, and it was the Nintendo Store that held the most restocks. The console flashed in and out of stock repeatedly throughout the day as limited units were sold and quickly snapped up. 🚨 Want the Zelda 40th Anniversary Switch 2? Drop your email for restock alerts before it sells out. ⤵️ Subscribe Many were met with error messages, “sold out” signs, or “couldn’t add the required amount” to their baskets. However, with a little persistence and luck, others were more successful. As it stands, it’s the best place to try to get the Zelda Switch 2, even if the experience can be a little frustrating. We’re expecting a similar situation today as our tracker continues to receive restock alerts. However, we’re reluctant to share them all as many have been false flags, but we immediately notified The Shortcut followers once the first restock went live. [ The Shortcut@theshortcut Zelda Switch 2 is back in stock at the Nintendo Store: nintendo.com Nintendo Switch™ 2 – The Legend of Zelda™ – 40th Anniversary Edition - Nintendo Official Site 4:18 PM · Oct 29, 2026 · 2.09K Views 2 Replies · 2 Likes ](https://x.com/theshortcut/status/2115840807773299128?a=b6yhtCFmoswv5lWWvEs&s=20) Amazon was the only other retailer to hold an online restock, though it sold out almost instantly. No more restocks took place, and sadly, the major Walmart restock of the Zelda Switch 2, which we were confident would take place, did not happen because of a supply chain issue. [ Matt Swider (The Shortcut)@mattswider ](https://x.com/mattswider/status/2115824408938111299?a=quc3qYd6I_Qe5wag2lU&s=20) 🚨 Zelda Switch 2 console at Amazon right now amazon.com/dp/B0HJ6F8L6V?… amazon.com Nintendo Switch™ 2 –The Legend of Zelda™ – 40th Anniversary Edition 3:13 PM · Oct 29, 2026 · 76.7K Views 32 Replies · 4 Reposts · 57 Likes The console will now be available to order online at Walmart on November 6, with Target also offering the same date. Some lucky shoppers could also get the Zelda Switch 2 in-store, with The Shortcut readers sharing their personal accounts of getting the console at Walmart and helping each other out. If you’re willing to travel to your local store, Best Buy and Nintendo are holding in-store events on November 5 (though you’ll need a Warp Pipe Pass for Nintendo’s event). GameStop is also letting customers pre-order in-store.. We’ll still be tracking every retailer with our exclusive Zelda 40th anniversary Switch 2 restock tracker, which provides up-to-the-second information when the Zelda Switch 2 is in stock. If the console appears – which it might – our followers will still be the first to know. Up next: PS5 Pro restock: it’s available again, but you’re paying more than you should Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
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The politics of war
Israel went to the polls last Tuesday and it is the turn of the United States next Tuesday. The differences in the two elections are self-evident. Compared with the US, which has favourable geography and does everything at scale, Israel is tiny and part of an unstable region. For its elections, it has adopted an almost pure form of proportional representation based on lists. This encourages multiple parties and can make it almost impossible to form a government, as we can now see. The US system is complex in its own way but discourages third parties. Yet for all the differences in size, geography, and political systems, the fates of the two countries are closely connected. Israel has come to depend on the US to sustain its military strength, and over the past few tumultuous years that dependence has created resentment in the United States. The Biden administration was punished for appearing to give Netanyahu a blank check after the Hamas attacks of 7 October 2023, and not holding Israel back as it employed ruthless tactics in Gaza. Because of the treatment of Palestinians, American views of Israel have grown progressively more negative over the past few years. Only a third now support the Israeli government. While on the left, this is largely because of how Israeli forces have operated in Gaza and, more recently, how the settler movement has behaved in the West Bank, for the American right the issue has been about how Benjamin Netanyahu persuaded Donald Trump to forget his wariness about more Middle Eastern wars and agree to a joint attack on Iran, which has gone badly wrong. The Palestine question was not a big issue for the two large Jewish blocs in last Tuesday’s election. Both supported a tough response to Hamas after October 2023 and neither accepts a two-state solution. It was, however, the threat posed by the ethno-nationalist policies of Itamar Ben-Gvir and Bezalel Smotrich, the two extreme members of Netanyahu’s coalition, and their tolerance, even encouragement, of settler violence, that brought out the Arab voters. (In principle this should strengthen their position though to turn into real power would require the ‘Change Bloc’ overcoming their opposition to involving Arab parties. The alternatives are a National Unity government, defection from the Change Bloc to Netanyahu, or deadlock and another round of elections in the new year.) There was also broad support for the war against Iran among the Jewish parties. The difficulty here is that the objectives behind the war have yet to be met, and that continuing with military operations depends on the United States. In this way the two elections have come together at a crucial moment. If Netanyahu hoped that a victory over Iran would help him retain his majority, cementing his legacy as an Israeli war leader, it did not work out that way. Trump also expected a great victory about which he could boast. He promised at most the end of a hateful and aggressive regime, with a record of hostility to both the United States and Israel, or at least the elimination of Iran’s military capabilities and the end of its nuclear programme. Eight months on, there is not much to boast about; vital objectives remain elusive: the Iranian regime is even more hardline than before; the international economy is barely coping with the closure of the Strait of Hormuz; and Saudi Arabia is struggling with an unwanted conflict with the Yemeni Houthis. For all these reasons, the Iran War has been a dark cloud hanging over both elections. Yet the issue has been approached in different ways. Netanyahu sought to push the issue before the election while Trump has been more cautious. Trump’s essential claim is that there is nothing to worry about and he’s still working out what final steps need to be taken to provide a definitive conclusion to the conflict. Netanyahu’s final pitch was that there was lots to worry about. He focused on Israel’s dire security situation, with the Iran War unfinished and the prospect of imminent economic isolation because of international sanctions. For him it is imperative to defeat Iran decisively, and without delay. Why this different response to the same war? Part of the answer lies in how public opinion in the two countries responded to the war. In this post, I show how this came about. We await the outcome of the US midterms but know the result, at least in terms of the share of the vote if not yet the shape of the new government, of the Israeli election. With the elections out of the way Netanyahu is pressing for another round in the war. Trump is less sure. I conclude with thoughts on the importance of how he decides.
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Zelda 40th Anniversary Switch 2 restock: Walmart and Target confirm exact release dates
🎮 The Zelda 40th anniversary Switch 2 is out today, October 29, but Walmart and Target are planning online restocks for November 6 🚨 Our Zelda Switch 2 restock tracker @mattswider on X will send out an alert as soon as stock appears 👀 Walmart was our top pick to have a restock, but a supply chain delay has pushed the date back ⌚ GameStop, Best Buy, and Nintendo are holding in-store midnight launches where units will be available Walmart: Zelda Switch 2 console Best Buy: Zelda Switch 2 console GameStop: Zelda Switch 2 console Target: Zelda Switch 2 console Nintendo: Zelda Switch 2 console 🚨 We’re tracking Zelda Switch 2 stock updates. If you’d like to know when more stock arrives, follow Matt Swider on X and turn on notifications. You can also become a free or paid subscriber to The Shortcut to help support our work. 🚨 A new update has dashed our hopes of a major Walmart restock of the Zelda Switch 2 console, which we were confident would happen today. However, a new Reddit post (thanks, Wario64) has revealed that Walmart is waiting until at least November 6 to sell the special edition console online. 🚨 Want the Zelda 40th Anniversary Switch 2? Drop your email for restock alerts before it sells out. ⤵️ Subscribe A employee note says: “Due to a supply chain delay, some stores may not receive the Nintendo Switch 2 Zelda 40th Anniversary Edition in time for its planned Oct. 29 release. To allow time to fulfill preorders and reshop inventory as needed, the point-of-sale (POS) block will remain in place through at least Friday, Nov. 6. As inventory arrives, orders will be fulfilled based on preorder priority and available inventory.” The Redditor who posted the news shared that some people were able to get the console from Walmart after 8:00am local time, so there is still hope. Target recently updated its Zelda Switch 2 listing to reveal that it will also start taking orders of on November 6, with in stores orders beginning November 5. Clearly, the supply chain delay is impacting other stores, otherwise we likely would have seen a restock take place today, as we initially predicted. We now know that Walmart and Target will be taking online orders, and that Best Buy and Nintendo are holding in-store events on November 5. GameStop is also letting customers pre-order in-store via their website. Despite the news, we’ll still be tracking every retailer with our restock tracker, which provides up-to-the-second information whether something is in stock. If the Zelda Switch 2 does appear – which it might – our followers will still be one of the first to know. Up next: PS5 Pro restock: it’s available again, but you’re paying more than you should Subscribe Adam Vjestica is The Shortcut’s Senior Editor. Formerly TechRadar’s Gaming Hardware Editor, Adam has also worked at Nintendo of Europe as a Content Marketing Editor, where he helped launch the Nintendo Switch. He also runs a retro gaming YouTube channel called Game on, boy! Follow him on X @ItsMrProducts.
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The Israel debate reshaping Jewish American politics
“There are plenty of people who believe, as I do, that Israel has a right to protect itself,” says David to Lauren, both pictured below, over the dinner table. Subscribe “How does starving children protect Israel?” she replies. “I don’t think Israel is intentionally starving children.” “It’s a little bit absurd to be sitting here talking about all of these very specific things,” Lauren says, “as opposed to looking at the totality of him as a candidate, and the 90% of things that you agree with him on.” This is a snapshot from a conversation between a Jewish father and daughter in Michigan ahead of the crucial Senate race. Lauren supports the Democratic candidate, Abdul El-Sayed. Her father is undecided. That is mainly because of El-Sayed’s stance on Israel, one that mirrors a growing wing of the party that has become critical of the US-Israel relationship following the war in Gaza. You’re reading FourSight, a newsletter from Channel 4 News’ expert journalists explaining the complexities of the biggest global stories Could that alienate Jewish American voters who have a strong connection to Israel - and the majority of whom have voted Democratic? A shifting stance on Israel “An ally that takes your money to push you into wars you shouldn’t be fighting is not an ally,” El-Sayed recently told ABC News, referring to the Iran war and how some Americans believe that Israel pushed President Trump into the conflict. Foreign policy has become an economic issue that’s hitting Americans’ pockets, with the soaring cost of petrol and diesel. El-Sayed, pictured below, has opposed military aid for Israel and accused the nation of genocide in Gaza. That led to the pro-Israel lobby group, AIPAC, funding his opponent, Hayley Stevens, to the tune of $30m during the Democratic primary here. “I frequently criticise AIPAC because I think the way that they are pouring dollars into defeating Abdul and others around the country… is really corrosive to American democracy,” Brad Lander says at a canvassing event in Detroit. Lander, a Jewish Democratic congressional candidate in New York, is an ally of Mayor Zohran Mamdani and has come to campaign for El-Sayed. “Democrats and Americans don’t want to keep paying for Netanyahu’s wars,” he says. “They want a reset in the US relationship with Israel.” The 2026 election has clearly been a bruising one for AIPAC; the Wall Street Journal reported that, in an unpublished letter, the group described the cycle as one of the “most challenging environments in recent memory”. Share And significantly, after the midterms, the group will stop direct contributions to candidates through one of its political action committees. Voters’ concerns We followed a group of Jewish canvassers around one suburb in Detroit. They think that among the 130,000 Jewish voters in Michigan, between 20 and 30,000 are undecided. In a swing state where El-Sayed beat his primary rival by just 13,000, that could prove pivotal. We meet one voter, Jen Friedman, pictured below, who has a “Democrats for Rogers” sign, referring to the Republican candidate. The issue of Israel is very important to her because “having a safe haven is crucial”, she tells me. “What I see is one candidate, Mike Rogers, who is associating himself with people who are very proudly American,” says Jen. “Abdul, on the other hand, is associating with people who say they are anti-American.” Friedman raises two issues. Firstly, Hasan Piker, a left-wing streamer who has campaigned alongside El-Sayed and has been criticised for his comments on the US and Israel. [ ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) [ Why Hasan Piker thinks the US needs a socialist Trump ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) Anushka Asthana · Aug 19 [ Read full story ](https://channel4news.substack.com/p/who-is-hasan-piker-the-socialist) The other concern regards an attack on a Michigan synagogue back in March. The FBI said the man was inspired by Hezbollah and had lost relatives in an Israeli airstrike on Lebanon. El-Sayed condemned the antisemitic attack, but also said “hurt people hurt people”. That upset many here, with El-Sayed apologising numerous times for his choice of language. Jews for Abdul As we follow the canvassers, there are still plenty of lawn signs supporting El-Sayed. Elissa Driker, pictured below, runs out of her house wearing a “Jews for Abdul” t-shirt. “I feel like the values that Abdul has align with how I live my Judaism,” she tells me. She says “Abdul is not Hasan Piker, so I don’t conflate them”. I ask why Piker keeps coming up. “It gets weaponised. I don’t know if you watched the debate the other night, but talk about… weaponising fear and weaponising anxiety and all that Islamophobic dog-whistling that was coming towards Abdul.” I also talk to Elissa about how Americans more broadly appear to be questioning the US-Israel relationship and whether American Jews were ready to do that too. “A lot of American Jews are. My experience is absolutely the tide is turning.” For the first time, Gallup found this year that Americans now sympathise more with the Palestinians than the Israelis. In another poll of Jewish American voters, 65% said they were pro-Israel but also critical of Israeli government policies, 52% support cutting or eliminating aid to Israel. Father and daughter Back at the dinner table, I bring up those polls with David Fink. Why does he think Americans sympathise less with Israelis? [ ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) [ How support for Israel in US is declining ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) Kiran Moodley · May 4 [ Read full story ](https://channel4news.substack.com/p/how-support-for-israel-in-us-is-declining) “Because the news media and the extremes of both parties are so willing to tell what I think is a false narrative.” Lauren chimes in: “Do you really think the actions of Israel have nothing to do with the shift in the sympathies?” “I think that’s very relevant,” he replies. “I just don’t think that people really have a full understanding.” Lauren again: “It sounds like you’re saying that the shift is due to how the atrocities are being described, as opposed to what the actual atrocities are.” “There have been some things that shouldn’t have happened,” David says. “I think the polling is being driven by politicians who are taking advantage of this issue.” Lauren then asks, “I’m curious what your response would be if my children were killed in an Israeli airstrike and someone said there have been some things that shouldn’t have happened?” A long pause from her father. “Any reference to my grandchildren has a very deep emotional impact on me. Well done,” he says. “I have an empathy for any civilian in war and I don’t mean to belittle those losses. The loss of any one life is a horrible thing. But it doesn’t make it a war crime and it doesn’t make it genocide.” Lauren and David cannot agree but tell me how proud they are of one another for sticking to their convictions and for agreeing to let me sit in on their conversation. I cannot thank them enough for their time, and hope their honesty informs and educates many people during such a fraught election. Abdul El-Sayed: The candidate testing the US - Israel relationship Thanks for reading our latest FourSight newsletter. Subscribe to receive free weekly newsletters from Channel 4 News. Subscribe Share Channel 4 News Leave a comment
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A golden age of science is coming
It’s almost hard to remember, but just a few years ago, a lot of very smart people thought that science was in terminal decline. Respected researchers were writing papers with titles like “Are Ideas Getting Harder to Find?”, “Papers and patents are becoming less disruptive over time”, and “Slowed canonical progress in large fields of science”. In 1996, science writer John Horgan even published a book called The End Of Science: Facing The Limits Of Knowledge In The Twilight Of The Scientific Age. The fundamental idea was that the Universe only has so many insights to discover, and that we’ve picked the low-hanging fruit. It was the idea that Joseph-Louis Lagrange expressed when he said that “we cannot find more than once a system of the world to establish.” As the big ideas and the simple ideas get mined out, we’re forced to throw ever more brains at the mysteries of nature just to keep scientific progress going at a fraction of its old pace: It looked like science was hitting a wall. Then along came AI. It’s far too early to tell how much AI will eventually speed up the growth of total factor productivity. But already we can see signs of a speedup in science. Anthropic Founder Jack Clark assembled some of the hopeful data points in a recent lecture: [ Dror Poleg@drorpoleg "If you pick different parts of science, you see the same pattern show up: Progress is accelerating, and it has started to accelerate in the last two years." Jack Clark @jackclarkSF I’m speaking at the IMF in an hour about the singularity and why I believe it has begun and the choices we'll need to make. Watch live here: https://t.co/Hj9HzcXx5h 6:08 PM · Oct 18, 2026 · 21.2K Views 2 Replies · 10 Reposts · 123 Likes ](https://x.com/drorpoleg/status/2111882070376980529) Anthropic is accelerating its investment into drug discovery, and is already announcing some impressive preliminary results: [ BioTender@Junioryu136689 BREAKING: Anthropic unveils early results from six Claude-powered drug development collaborations. • 70% shorter CAR-T signaling domain • ~35,000 antibody designs • >10× tighter antibody binding • 89% less batch-record review time Still largely preclinical. Anthropic @AnthropicAI Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of 9:43 PM · Oct 27, 2026 · 11.2K Views 3 Replies · 24 Reposts · 205 Likes ](https://x.com/Junioryu136689/status/2115197821150495150) Claude also appears to be enabling rapid progress toward a treatment for food allergies. OpenAI, meanwhile, announced a possible breakthrough treatment for neurodegenerative disease. Meanwhile, Google Cloud Chief Scientist Pushmeet Kohli has a list of recent scientific advances that have been enabled by its new Gemini model, including breakthroughs in nuclear fusion reactor design, rare disease research, and quantum computing: [ Pushmeet Kohli@pushmeet Gemini 4 Argon is a step change in model performance. In recent weeks, it has had a transformative impact on the Science projects in our team at @GoogleDeepMind and our external collaborators, and helped make a number of remarkable advances across scientific disciplines. 🧵👇 4:47 PM · Oct 13, 2026 · 36.5K Views 8 Replies · 41 Reposts · 497 Likes ](https://x.com/pushmeet/status/2110049807385702623) But as cool as these stories sound, they’re just very minor, preliminary efforts. There are a number of reasons to think that AI is going to propel us into a golden age of scientific discovery. That age might not last forever — AI might still run into diminishing returns eventually. But the next few decades are probably going to be an absolutely amazing time for human science. The number of “effective researchers” is no longer limited The most important input into science is scientists themselves. Until this year, that meant human brains — talented, highly trained human brains. The number of trained human brains could be increased by sending more people to grad school, but only to a point — the smartest people tend to be sent into the hardest research fields first, and if you 10x the number of researchers, the average quality will go down. This constraint was already starting to bite, as Ekerdt and Wu argued in 2024: We argue that a substantial portion of the downward historical trend in U.S. research productivity is a composition effect resulting from self-selection in researcher ability and the dramatic expansion of the research sector…[W]e find that this composition effect has lowered average researcher ability by between 37% and 53%[.] And of course, low fertility was making the problem worse, because fewer children meant fewer people who were able to become future scientists. AI just blows up this constraint completely. If an AI agent can function as an autonomous researcher, there’s no constraint on the number of researchers in the world — you can just build more of them, by building more computer chips and data centers that enable the running of more AI agents. Whether or not massive hordes of agents can collaborate to solve individual problems much faster, increasing the number of agents allows them to tackle many different research questions in parallel. What’s more, these AI “researchers” can be trained incredibly quickly compared to human beings. A human scientist takes decades to train, and more years to reach the frontier of their research field by diligent reading and conversation. This is the “burden of knowledge”, and it’s commonly believed to be one reason ideas have been getting harder to find — by the time human scientists can get up to speed, they’re often so old that their ideas are no longer novel. AI just annihilates this constraint — it can assimilate the entire literature and reach the frontier of research extremely quickly, and it can also tell human scientists where the frontier lies without forcing them to discover that for themselves. It can also pivot to new research directions more easily than humans can. And there’s also a self-reinforcing economic cycle here. Because scientific advances enable higher GDP, they enable more resources to be invested into the creation of yet more electronic “scientists”. Now that doesn’t mean the amount of scientific research goes to infinity — there may still be some essential bottleneck task that human researchers are still needed to perform. There are some indications that AI’s progress on open-ended conceptual research tasks is slower than in other dimensions, and it may be that humans are still needed to provide some of this long-term conceptual thinking. I’d bet against this being true for much longer, but it might be true for a long time. Even in this most “pessimistic” case, though, the amount of effective capital that scientists can use to leverage their work just went up by a lot. AI eliminates the theory bottleneck Science proceeds by an iterative process of theory and experiment. The theory part of that cycle is typically short, but non-trivial — it took a couple of years after the blackbody radiation spectrum was observed for Max Planck to come up with the quantum hypothesis to explain it, and decades longer before quantum theory as we now know it was created. It took about a year for Watson and Crick to figure out the shape of DNA after the requisite data was gathered. AI will basically eliminate the theory bottleneck entirely — or at least shorten the turnaround time between experiment and theory by an order of magnitude. AI is an absolute beast at math. Recently, an OpenAI model solved some of the most important open problems in computer science, math, and theoretical physics, and no one even batted an eyebrow because that sort of triumph is becoming increasingly commonplace. One of those solutions was a proof that the Standard Model of Particle Physics could be mathematically well-defined — a problem that human theorists had so far been unable to tackle. Not all research relies equally on theory, but understanding novel experimental results almost always involves some important component of either mathematical or spatial reasoning. That part of the task has now been made much, much faster. And on top of that, science is now open to a greater number of humans who aren’t naturally good at theorizing. AI can read the whole literature Much of the work of human scientists involves reading and understanding endless amounts of papers and going to endless conferences and seminars. The purpose of that work is to understand the existing scientific literature. Understanding the literature allows scientists to do the following things: Come up with new ideas for hypotheses to test Avoid doing research that someone else has already done Synthesize approaches from different areas or fields AI can reduce this effort to almost zero. Consider this excerpt from OpenAI’s blog post about their new research into neurodegenerative disease: The team divided the analysis among thousands of AI agents powered by GPT‑Rosalind, an approach we call distributed biological reasoning. The agents examined a whole-brain CRISPR atlas…a dataset showing how gene disruptions affect different types of cells across the mouse brain. Each agent investigated a gene disruption, analyzed cellular responses, searched scientific literature, and proposed explanations for the results. Their reports were combined into a reasoning atlas linking genes, cellular effects, relevant publications, and possible biological mechanisms. The research team estimated that comparable human analysis and literature review, conducted one perturbation at a time, would take months to a year. The agents reproduced findings from human analyses while uncovering additional leads. Their assessments of novelty and scientific value also aligned with judgments from blinded human experts. These findings help prioritize further experiments needed to test the proposed biological mechanisms. Some of these insights point to new leads for understanding brain disease. [emphasis mine] This is one case in which parallel work by a large number of agents really does make a huge difference: [ Haider.@haider1 this is actually insane openai deployed thousands of GPT-Rosalind agents to analyze millions of mouse brain cells in 32 minutes, work that could take human researchers months to a year also the agents uncovered new leads for brain diseases like Alzheimer's and Parkinson's OpenAI @OpenAI GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in 2:41 PM · Oct 21, 2026 · 51.5K Views 26 Replies · 95 Reposts · 1.26K Likes ](https://x.com/haider1/status/2112917197903540516) Not only does instantaneous literature review vastly speed up the research process, but it allows AI to make novel conceptual leaps from combining approaches from wildly different fields of research. AI regularly does this in math research, combining results, approaches, and theorems from far-flung places that no human mathematician would have thought to combine. It can do it in science, too. Much of scientific innovation, historically, has been “recombinant” innovation — scientists applying insights from one field to another. With AI, essentially all research is now cross-disciplinary — AI can read not just the literature on a particular subject, but the literature on a million other subjects that might have produced useful techniques or insights for the problem at hand. Superscience So far, all of the factors I’ve listed are ways that AI can speed up science as it’s already done. I’ve basically described how AI can send gigantic hordes of superhumanly fast, superhumanly well-read, superhumanly mathematically gifted researchers to re-accelerate scientific discovery. But it’s also possible that AI will enable types of discovery — and ways of understanding the natural world — that no network of humans, no matter how large or how brilliant it was or how long it had to work, would ever be able to discover. In a post back in July, I wrote about how that might work: What if there are lots of…aspects of the Universe that [are] too complex to understand in terms of simple laws, but not so complex that they just dissolve into unknowable chaos? It’s possible that we can reliably control these complex phenomena with AI, even if we never reduce them to the kind of principles that we can teach a grad student in a textbook… Another way of saying this is that there may be laws of the universe that humans can’t understand but AI can. I call these “cloud laws” — causal regularities that can be exploited by technology, but which are too diffuse and complex for an individual human being to either intuit or communicate… Perhaps social sciences like economics, sociology, and political science obey similarly complex regularities, and AI can help us find them. Perhaps there are physical processes — plasma, or topological materials, or aerial turbulence, etc. — that obey cloud laws instead of chaos?… [H]uman collaboration is bottlenecked — it’s limited by our ability to intuit patterns at an individual level, and to communicate these patterns from one individual to another. AI, being a computer, just doesn’t have this sort of limitation; it can work with vast, diffuse patterns without having to break them into pieces or simplify them in order to compress them into the tiny pipelines of person-to-person explanation… If much of the Universe turns out to be ruled by cloud laws, we could be on the precipice of a scientific renaissance. In order to discover cloud laws, AI will need huge amounts of data about the natural world. AI figured out human speech by assimilating essentially all of the text humans have ever written. If it’s going to figure out hidden patterns in biology, neuroscience, materials science, etc., it’s going to need similarly massive amounts of data from physical instruments. That data will be far, far more than humans — individually or collectively — would be able to parse, label, characterize, or model. But AI was built to do this. If scientists simply build huge arrays of sensors to measure complex phenomena like the brain, the cell, the economy, etc., they may be able to feed this flood of data to AI directly and bypass human cognitive intermediation entirely. AI would then learn about the world directly, and it might learn things that humans never could. This “superscience”, if you want to call it that, would actually go beyond the kind of science humans have done heretofore. Many of the technologies it yielded would be beyond human comprehension — indistinguishable from magic. But to the AIs, they would make perfect scientific sense. In any case, it seems clear that the scientific slowdown that threatened human progress will now be delayed — at least for a while. Unless humans have somehow found most of the actual exploitable regularities in our Universe, we’re about to enter a new golden age of science. Subscribe Share
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