SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " Pipeline " 257 found 🔀 AI-powered Shuffle
Karpathy shares 'LLM Knowledge Base' architecture that bypasses RAG with an evolving markdown library maintained by AI
Karpathy proposes something simpler and more loosely, messily elegant than the typical enterprise solution of a vector database and RAG pipeline.
Spire announces sale of gas marketing business to Boardwalk Pipelines for $215 million
/PRNewswire/ -- Spire Inc. (NYSE: SR) today announced it has entered into an agreement to sell its gas marketing business, Spire Marketing Inc. (Spire...
Energy executive Alan Armstrong picked to fill Mullin's Senate seat through end of year
The choice by Republican Gov. Kevin Stitt, who had pledged to pick a “conservative voice” to fill Mullin's seat, elevates to the Senate the chairman and former CEO of Williams Companies, a major pipeline operator based in Tulsa.
Cockroaches with smart backpacks? Scientists turn insects into cyborgs to detect hidden pipeline leaks
Science News: Although the concept seems like something from science fiction, science is rapidly adopting it. Researchers have started creating ‘cyborg cockroaches,.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Microsoft Is Finally Ready to Make Windows 11 Less Terrible After Bloating It With AI Crap
Less Copilot, better search, and more taskbar customization are apparently in the pipeline.
Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment
Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share
Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
Alto Neuroscience Reports Full Year 2025 Financial Results and Recent Business Highlights
MOUNTAIN VIEW, Calif., March 16, 2026--Alto Neuroscience, Inc. ("Alto") (NYSE: ANRO), a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today reported financial results for the full year ended December 31, 2025, and highlighted recent progress across its pipeline of clinical-stage product candidates.
Thrivent bucks the AI layoff trend and plans to add 600 financial advisors this year: This is ‘how we grow our business’
The Fortune 500 company is ramping up a training pipeline to staff the next generation of advisors.
Health Care Roundup: Market Talk
Gain insight on eczema treatments, Roche Holding’s recent pipeline updates and more in the latest Market Talks covering the health care sector.
Wirral carbon capture pipeline plan 'threatens businesses'
Small business owners voice their fears about the impact of building a 200km (124 mile) pipeline.
Lasses Spotlight: “The PGA Pipeline”
“Amid the quietness of an international break, you can see the future of Sunderland Women taking shape.”
Apple still has over a dozen products in the pipeline for 2026, here's what's coming
Apple just wrapped up a very exciting week of announcements – starting off with iPhone 17e, and ending with MacBook...
AI discovers the hidden signal of liquid-like ion flow in solid-state batteries
Solid-state batteries could be safer and more energy-dense than today’s lithium-ion technology, but finding materials that allow ions to move quickly through solid electrolytes has been difficult. Researchers developed a machine learning pipeline that predicts Raman spectra and identifies a distinctive low-frequency signal linked to liquid-like ion motion inside crystals. This signal appears when rapid ion movement temporarily disrupts a crystal’s symmetry. The approach could dramatically speed up the discovery of superionic materials for advanced batteries.
Loaded Pirates Soar Up MLB Pipeline’s 2026 Farm System Rankings
The Pittsburgh Pirates are arguably the most improved team in baseball this year, both at the Major League and Minor League levels. At the MLB level, the Pirates have the second-best FanGraphs playoff odds in the NL Central after finishing last in their division last year. They appear poised for a big leap, especially at […]
MLB Pipeline drops Arizona Diamondbacks prospect list
While there have been other prospect rankings, from the likes of Fangraphs and 1500 Prospects, the list put out by MLB Pipeline is always seen as one of the most highly-regarded. Well, they just dropped the Diamondbacks list for the start of 2026. 30 prospects are ranked there, and here’s what they have, along with […]
Experts warn new graduate student loan limits could hurt health care pipeline
The U.S. Department of Education is weighing public feedback on a narrowed definition of who is considered a \
Must‑see sports landmarks to visit across the United States
From the Banzai Pipeline to Cooperstown and beyond, USA TODAY Sports editors reveal the 50 best sports landmarks to visit in United States.
The WHO Chief Thinks Trump Is Missing a Political Opportunity
WHO’s Dr. Tedros combats vaccine skeptics, a $3,000 minipig powers Europe’s drug pipeline, and we appear to be entering our trillionaire era.
Green hydrogen has a hidden problem and scientists may have fixed it
Green hydrogen could be a game-changer for the clean energy transition—but right now, it’s too expensive and still relies on harmful “forever chemicals.” A new EU-backed project called SUPREME aims to fix that by reinventing how hydrogen is made. Led by the University of Southern Denmark with partners across Europe, researchers are developing a PFAS-free electrolysis system that slashes the use of rare metals like iridium and dramatically cuts costs.
How Elana Meyers Taylor has kept the USA women's bobsled pipeline booming
Elana Meyers Taylor has triumphed both on the Olympic stage and behind the scenes as Team USA's top women's bobsled recruiter.
Live Nation Entertainment Full Year And Fourth Quarter 2025 Results
In 2025, the bond between artists and their global fan bases reached new heights, fueling another year of double-digit growth. As artists continue to unlock untapped markets and headline the world’s most iconic stadiums, we’ve built momentum that carries us into a record-breaking 2026. We’re not just building venues; we’re crafting world-class stages designed to elevate the artist’s vision and their connection to fans. By strategically expanding our global footprint and investing in premium, upgraded infrastructure, we provide the canvas for career-defining performances. This investment doesn’t just drive ticket sales—it revitalizes local economies and cements our venues as cultural anchors. With a deep pipeline of large-scale shows and ticket demand continuing its ascent, we are positioned for another year of double-digit operating income and AOI growth in 2026. Our commitment to being the ultimate partner for artists ensures we are set to compound this double-digit growth for years to come. – Michael Rapino, President and CEO
ECU Health announces new Academic Loan Scholarship Program to strengthen eastern North Carolina’s health care workforce
Investment helps build homegrown pipeline of skilled health care professionals
CRISPR Therapeutics Provides Business Update and Reports Fourth Quarter and Full Year 2025 Financial Results
ZUG, Switzerland and BOSTON, Feb. 12, 2026 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP) today reported financial results for the fourth quarter and full year ended December 31, 2025. “As we close out the fourth quarter, CRISPR Therapeutics continues to make steady progress across a broad and increasingly mature pipeline,” said Samarth Kulkarni, Ph.D., Chairman and Chief Executive Officer of CRISPR Therapeutics. “We made meaningful advances across multiple clinical and preclinical progr
PODCAST: How a proposed natural gas pipeline in CT cuts across typical partisan politics
WSHU's Ebong Udoma and CT Mirror's John Moritz discussed his article about a natural gas pipeline project that seems to buck partisan trends.
Wright blames New York politics for slowing gas project
The Energy secretary said the Constitution pipeline needs to get built, and he predicted that New York’s Democratic governor won’t stop it.
How JoySauce is building an Asian American comedy pipeline from the ground up
JoySauce launches its first ad-supported streaming channel on Amazon Prime dedicated to Asian American voices, premiering comedy series "Jokes with JoySauce" in January.
Creating a Data Pipeline to Monitor Local Crime Trends
A walkthough of creating an ETL pipeline to extract local crime data and visualize it in Metabase.
Todd Monken Continues Ravens Pipeline With Ian Kolste Hire
Former Ravens offensive analyst Ian Kolste is joining Todd Monken’s Browns staff, continuing Cleveland’s Ravens-influenced approach.
ECU Health North Hospital celebrates first graduating class of new CNA I program
Program invests in local talent, grows workforce pipeline for rural health care
Rebuilding Colorado’s talent pipeline system
By Randy Johnson The rule of thumb in designing and building anything is form follows function — you always build for a clear and specific purpose. This principle holds true for structures, vehicles, applications, seemingly anything, other than many educational systems and government functions. During the next few months, Colorado has a powerful opportunity to […]
Industry Leaders Predict Life Science Trends for 2026
2026 will be the year that artificial intelligence accelerates multiple aspects of the drug discovery and development pipeline, industry leaders predict.
Dodgers have 7 prospects in The Athletic top 100
It’s prospect-ranking season, with both Baseball America and MLB Pipeline unveiling top-100 lists last week. On Monday, Keith Law at The Athletic revealed his annual preseason ranking of the top 100 prospects in baseball. Seven Dodgers made this list, their most prolific showing yet among these groups. Just like at BA and MLB, four outfielders […]
Oil holds onto gains as Iran keeps investors on edge
Oil prices extended gains on Monday after climbing more than 2% in the previous session, as tensions between the U.S. and Iran kept investors on edge even after Kazakhstan's main export pipeline resumed full operations.
Five Brewers named to MLB Pipeline’s Top 100 Prospects
Made, Peña, Pratt, Williams, and Sproat all named top prospects by MLB Pipeline
California sues the Trump administration over plans to restart oil pipelines
The U.S. Transportation Department agency that approved the plan pushed back on the lawsuit
Mets news; Mets sign international free agent Wandy Asigen
The Mets grabbed the #2 IFA according to MLB Pipeline.
Ford gives some mechanics free Carhartt gear to attract talent
Ford, seeking to fill 5,000 open positions at its dealerships, is teaming with Carhartt in an effort to boost the auto technician pipeline.
Legend Biotech Highlights Recent Business Updates at 44th Annual J.P. Morgan Healthcare Conference
Exceeded 10,000 patients treated to date with CARVYKTI® (ciltacabtagene autoleucel; cilta-cel)Increased CARVYKTI® manufacturing capacity with the physical expansion of the Raritan facility, now the largest cell therapy manufacturing facility in the U.S.Profitability expected in 2026, driven by continued CARVYKTI® revenue growth and operating margin expansion Treated first patient with in vivo pipeline candidate in investigator-initiated trial Preclinical data from primates provided early validat
Moderna Provides Business and Pipeline Updates at 44th Annual J.P. Morgan Healthcare Conference
Expects 2025 revenue of approximately $1.9 billion (unaudited), $100 million above midpoint communicated on 3Q25
Moderna Provides Business and Pipeline Updates at 44th Annual J.P. Morgan Healthcare Conference
Expects 2025 revenue of approximately $1.9 billion (unaudited), $100 million above midpoint communicated on 3Q25 Earnings Call Improves 2025 expected GAAP operating expenses by $200 million since 3Q25 Earnings Call Increases 2025 projected year-end ...
Healthy Returns: What to expect from pharma at the JPM conference
At the JPMorgan Healthcare Conference, drugmakers are expected to roll out key business and drug pipeline updates and splashy M&A deals.
How Recent Developments Are Shaping The Sphere Entertainment (SPHR) Investment Story
The latest valuation work on Sphere Entertainment has lifted the fair value estimate from US$75.30 to US$88.30, supported by a slightly lower discount rate at 9.87% and a small increase in the revenue growth assumption to 6.03%. These tweaks build on Street research that has become more constructive, with bullish voices pointing to Las Vegas Sphere performance, a fuller content pipeline and recent earnings data. Cautious analysts, however, still question how durable current attendance trends...
Trump says water pipeline veto was because of cost, but critics say it's retribution
President Trump has vetoed a bill to help finish a water pipeline in Colorado, saying it's about "fiscal sanity." Critics say the president's veto is a form of political retaliation.
Top HIV Science Stories of 2025
Twice-yearly PrEP makes its debut, novel HIV treatments are in the pipeline and metabolic health gets more attention.
Ohio to get $200M in federal money to aid rural health care, but feds haven’t yet said how
Ohio will get $200 million in federal funding as part of a 5-year, $50 billion program to bolster rural health care. State plans include expanding child vision services and creating the Rural Healthcare Workforce Pipeline, but guidelines for spending flexibility remain unclear.
Business leaders look to 2026 with optimism, while project pipeline has yet to come into focus
What kind of a year does the business community anticipate for 2026? We checked in with many local leaders for a look at what the year could hold.
The Metadata Mission: How the ARC Project's Legacy Enriches Earth Science Data
The Analysis and Review of the Common Metadata Repository (ARC) project is transitioning to ESDIS management and will continue to ensure that NASA’s Earth observation metadata records are correct, complete, and consistent.
Future of federal support for Va. minority-, women-owned businesses in transportation in question
Business owners in Virginia, Illinois and Arkansas say the program has offered systemic corrections, created jobs, and built a workforce pipeline, but fear all of it is at risk with the pending federal changes.
Linux 6.19 Features: LUO, PCIe Link Encryption, ASUS Armoury, DRM Color Pipeline API & More
With Linux 6.19-rc1 released, the merge window for Linux 6.19 has now concluded.
Committee rejects Debbie Wasserman Schultz language protecting Everglades from pipeline fast-track
Legislation streamlining pipeline approvals will head to the House floor without any exemptions for Florida waterways.
Goldman Sachs exec says banker talent 'competition remains intense' as Wall Street battles for dealmakers amid M&A cycle
Goldman CFO Denis Coleman says a hot M&A pipeline is fueling fierce competition for talent as Wall Street heads into 2026.
Health Care Workforce: A System Under Pressure, Poised for Reinvention
AHA's 2026 Workforce Scan highlights six pressures that will define workforce strategy in the coming years: financial stress that limits flexibility; demographic shifts that increase demand; rapid technological transformation; changing worker expectations; the urgent need for new pipelines; and geographic disparities that threaten access.
Addressing eminent domain for carbon pipelines among top priorities next Iowa legislative session
Iowa lawmakers are expected to revisit the issue of eminent domain for carbon capture pipelines in the upcoming legislative session, with environmental groups and the ethanol industry presenting opposing views.
China's top universities plan to roll out 'embodied intelligence' majors to fuel Beijing's robotics push
Seven Chinese universities plan to launch an "embodied intelligence" major as Beijing races to build a pipeline of robotics and AI talent.
The pipeline that nurtures the next generation of young scientists is at risk
When young scientists collaborate with more senior colleagues, the results lead to stronger science.