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An AI model has found a new ‘CRISPR-like’ biological system. Here’s what it means for science
After coding, mathematics and chatbots, AI companies are setting their sights on the messy world of biology.
Citrus Health Network director accused of stealing more than $1 million
Thomas Jardon is being held on a $700,000 bond after being accused of stealing $1.2 million in public dollars from the Miami-Dade County Homeless Trust.
New Jersey Politics (Episode 529)
This week on New Jersey Politics, a new law signed by Gov. Mikie Sherrill creates an employee-ownership transition program through the NJEDA, with education,
40-acre sports and entertainment complex planned for Leander
Game Changers Field of Dreams Inc. is making progress on a big sports complex north of Austin in Leander.
Trump SBA to Extend Comment Period After Ranking Member Markey Leads Effort to Rescind SBA Policy that Reclassifies Billion-Dollar Businesses as “Small Businesses”
Trump admin policy would reclassify 114,000 larger businesses as “small” to access small business resources and win federal contracts meant for small businesses Letter (PDF) (Washington, September 23) – This week, the Small Business Administration (SBA) announced its plans to extend the deadline to submit comments on its controversial proposed rule regarding small business size standards until November 20. The Trump SBA’s announcement came shortly after Ranking Member Edward J. Markey (D-Mass.), alongside 12 of his Senate colleagues, sent a letter to Administrator Kelly Loeffler demanding that the Trump SBA rescind a harmful policy that would dramatically redefine what a small business is. The Administration’s proposed policy would change the small business size standard to designate 114,000 larger companies some with annual revenue above $1 billion—as small businesses, giving these businesses access to small business resources and federal contracts typically set aside for actual small businesses. In the letter, Ranking Member Markey and the lawmakers emphasized that small businesses will be shut out of the federal contracting space as government agencies award contracts to larger businesses, causing small businesses to lose revenue, lay off workers, or close their businesses entirely. “For more than 70 years, SBA’s mission has been clear: promote and protect the interests and viability of small businesses. By proceeding with this proposed methodology and rule, SBA moves further away from its mission of facilitating healthy small business participation in the U.S. economy. We urge SBA to rescind these proposals, meet in earnest with small businesses across the country, and discuss the proposal and methodology with congressional committees of jurisdiction. SBA must be committed to developing measured increases to the size standards that do not reward large, billion-dollar companies but instead helps our small businesses survive, grow, and thrive.” The lawmakers highlighted the following points in their letter: Under the Trump SBA’s new size standards, the highest receipts-based standard would exceed $1 billion in annual revenue—more than 20 times the current $47 million maximum—and the highest employee-based standard would reach 3,600 employees—more than twice the current 1,500 employee maximum. Specific increases include an increase in size of nearly 492% for banks, 1,500% for law firms, and more than 2,051% for private equity firms. Of the 114,000 businesses that would be newly classified as small, more than 37,000 of these businesses have collectively won more than 100,000 federal contracts worth approximately $71 billion in Fiscal Year 2025 alone without a small business designation. If SBA included the awards won by these 37,000 businesses in its Fiscal Year 2025 analysis, small business contracts would have accounted for 38% of all federal contracts, instead of the 27% that SBA announced this summer. The letter was co-signed by Senators Mazie Hirono (D-Hawaii), Angela Alsobrooks (D-Md.), Richard Blumenthal (D-Conn.), Christopher Coons (D-Dela.), Elissa Slotkin (D-Mich.), Chris Van Hollen (D-Md.), Jacky Rosen (D-Nev.), Elizabeth Warren (D-Mass.), Tim Kaine (D-Va.), Brian Schatz (D-Hawaii), Mark Warner (D-Va.), and Ruben Gallego (D-Ariz.). Ranking Member Markey is fighting to protect small businesses in Massachusetts and across the country from the Trump SBA’s harmful policies that put big businesses and billionaires over American small businesses, workers, and families. In August, Ranking Member Markey slammed the Trump SBA’s proposal to overhaul its small business size standards to benefit big businesses over small businesses. In July, Ranking Member Markey and House Small Business Committee Ranking Member Nydia M. Velázquez (D-NY-7) introduced a Congressional Review Act (CRA) resolution to rescind the Trump administration’s policy that bans green card holders from accessing essential Small Business Administration (SBA) loans to start and grow their businesses. Also in July, Ranking Member Markey and Senator Hirono submitted a comment letter to the Small Business Administration (SBA) opposing a proposed rule change by Trump’s SBA to the 8(a) Business Development Program that would harm underserved small business owners and entrepreneurs. In June, Ranking Member Markey released a new report highlighting Trump’s drastic reduction in federal contracting dollars awarded to American small businesses. ###
Iowa judge dismisses Trump’s lawsuit against Des Moines Register and pollster
A judge in Iowa has dismissed President Donald Trump’s lawsuit against The Des Moines Register and its former pollster. Trump sued in December 2024, accusing pollster J. Ann Selzer and
Justin Verlander Reveals How Long He Will Pitch on Saturday
A.J. Pierzynski says Justin Verlander plans to push for 100 pitches and pitch “until my arm falls off” in his final MLB start.
Tutta Bella scales back restaurants as it shifts focus to wholesale business
Tutta Bella closes multiple Seattle-area locations to focus on wholesale pizza production through its Kroger distribution deal.
Betsy Devos, education advocate, business leader, philanthropist
DeVos is a longtime education advocate and one-time U.S. Secretary of Education under President Donald J. Trump.
Police investigating theft from State College business, look to identify person of interest
STATE COLLEGE, Pa. (WTAJ) — Police are asking the public for help in connection with a theft investigation in State College. According to Ferguson Township Police, the incident occurred Wedne…
New Jersey Department of Health Celebrates Newborn Screening Awareness Month, Public Health Laboratory Appreciation Month and Continues to Lead Robust Newborn Screening Efforts Statewide
New Jersey Department of Health Celebrates Newborn Screening Awareness Month, Public Health Laboratory Appreciation Month and Continues to Lead Robust Newborn Screening Efforts Statewide
China Capital stories reveal how ICBC advanced China’s political goals across four continents
ICIJ’s media partners uncovered strategic deals and moves the Chinese bank made around the world to further the political priorities of the party-state.
NJ Business Council for Childcare Launches to Strengthen NJ’s Workforce and Economy
ATLANTIC CITY — Today, the New Jersey Business Council for Childcare officially launched, bringing together some of the state’s most influential business organizations and employers to address childcare as a critical workforce and economic issue. Advised by Moms First, the statewide, business-led coalition includes the New Jersey Business & Industry Association (NJBIA), New Jersey Chamber of[...]
Who won the NEBA forum? Derzypolski, Perez compete for business vote
Tallahassee commission candidates Tom Derzypolski and P.J. Perez shared their plans for city growth at a recent forum.
Leadership, politics and life with Eido Walny
Steve Scaffidi sits down with estate-planning attorney and Bayside Village President Eido Walny for a wide-ranging conversation about building a career,
Florida developer splashes into Raleigh with 264-unit project near Downtown South
Hillpointe, a Florida developer, plans a 264-unit apartment community near Raleigh's Downtown South development on Rush Street.
JPMorgan Weighs Opening Card Business to Private Credit
J.P. Morgan Chase is reportedly exploring whether other funding sources could approve some of the cards it rejects. That's according to a report late
King Pigeon, under new ownership, reopens following seven-month closure
King Pigeon reopened Friday under new owner Jesus Andres after a seven-month closure, offering coffee from La Cabra and pastries in Walnut Hills.
Trump call for supporters to cheat undermines fraud claims
Richard M. Nixon famously declared, 'I am not a crook.' Donald J. Trump, his approval rating slumping toward Nixonian levels, is urging his backers to act like crooks in November's election.
Decree Promulgating Ethical and Religious Directives for Catholic Health Services
FOR IMMEDIATE RELEASE September 23, 2026 The Most Reverend Frank J. CaggianoBy the Grace of God and Authority of the Apostolic See Bishop of Bridgeport DECREE PROMULGATING ETHICAL AND RELIGIOUS...
Mayor Katie Wilson's budget aims to close $175 million gap with no new taxes
Seattle Mayor Katie Wilson's $9.1 billion budget aims to eliminate a $175 million deficit without new taxes by cutting spending and redirecting JumpStart revenues.
Longtime Davie mayor gets challenge from political newcomer
The incumbent mayor of Davie has held the seat for more than 15 years but her opponent in November’s election is a newcomer who says she has fresh eyes.
Bring your sick soybeans to Farm Science Review!
By Horacio Lopez-Nicora, Ohio State University Soybean Pathologist and Nematologist, Adapted from C.O.R.N. 2026-31 Seeing disease symptoms in your soybean fields? Bring us your sick soybeans at Farm Science Review! During Farm Science Review, September 22–24, the OSU Soybean Pathology and Nema
Third-generation CEO Andy Heily shifts Krusteaz’s focus as consumer tastes change
Andy Heily, third-generation CEO of Krusteaz Co., discusses leading the Tukwila food manufacturer and balancing family business with personal passions.
Microsoft lays off 300 employees in WA
Microsoft cuts 268 Xbox roles as new CEO Asha Sharma tries to revamp the gaming division.
Velocity Arts targets 2029 opening for Gardner entertainment campus
Gardner City Council approves Velocity Arts' $1.55 billion entertainment campus with concert pavilion, hotel and esports arena planned for 2029 opening.
Jeffrey Adams, an established restaurateur's first business, is closing after 14 years
Jeffrey Adams on Fourth, an upscale New American restaurant in downtown Winston-Salem, closes after 14 years due to financial challenges.
Sen. Lesser Statement on Trump Administration Healthcare Cuts
Sen. Lesser Statement on Trump Administration Healthcare Cuts Today, State Senator Matt Lesser, Senate Chair of the Human Services Committee, issued a statement in response to Vice President J.D. Vance announcing that 760,000 Americans will be losing health insurance. The Vice President claims that 760,000 people were fraudulently enrolled in Affordable Care Act coverage, and 419,000 more people would face…
A.J. Hinch Reveals What He Told Tigers After Elimination
A.J. Hinch told the Tigers they fell seven days short after Sunday's elimination. #Tigers
Par Health recalls IV sedative in US, flagging presence of cellulose, stopper material
Par Health has issued a
Governor Evers points to K-12 funding as unfinished business as tenure winds down
WISCONSIN DELLS, Wis. -- With only months remaining in his tenure, Governor Tony Evers says increasing support for Wisconsin's public schools is one area
The Maker’s Toolbox: Bambu Lab R1 CO2 Laser Cutter Review
I’ve spent the past couple of weeks testing the new Bambu Lab R1 and have a lot of thoughts to share with you.
Political science department holds bipartisan midterms panel
The Department of Political Science last Wednesday hosted "Perspectives on the 2026 Midterm Election” as part of the Peter J. Hoagland Integrity in Public Services Lecture Series at the Sheldon Museum.
Homebuilding permits plunge in Charlotte metro as builders face infrastructure issues, rising land prices
Building permits in Charlotte dropped 17.7% through July as zoning and infrastructure challenges constrain homebuilder supply.
URochester developing Doctor of Physical Therapy program amid broader health sciences expansion
The University of Rochester is developing a doctor of physical therapy program to expand its health sciences education and research offerings.
New poll reveals which political party has a 5-point advantage ahead of November elections
Democrats hold a 5-point advantage over Republicans with just over a month to go before the midterm elections
Quincy private jet company sees 10% sales growth as sporting events drive bookings
Sentient Jet's CEO credits pandemic-driven demand and major sporting events for the Quincy company's 10% annual growth in private aviation.
PeaceHealth to lay off 150 Washington workers in technology overhaul
PeaceHealth lays off 150 workers statewide as the nonprofit health system moves IT services in November under new CEO Sarah Ness.
Detroit Tigers Announce Sudden Max Clark Move Before Nationals Series
The Detroit Tigers were officially eliminated from the postseason over the weekend after making it in each of the last two seasons.It was simply an underwhelming 2026 campaign for them, and on Monday night, they’ll begin a series against the Washington Nationals as they wind down the regular season.Ahead of the matchup, Tigers manager A.J. […] The post Detroit Tigers Announce Sudden Max Clark Move Before Nationals Series appeared first on HEAVY.
New facility at K-State brings grain, food and animal science together
K-State's Western Star center brings grain, food and animal science programs together for research and hands-on education.
NYC Health + Hospitals’ Dental Residency Program Wins Highest Recognition in Dental Education
New York, NY – NYC Health + Hospitals today announced its system-wide dental residency programs received the 2027 William J. Gies Award for Eminence in
Ernst and Young selects new Boston managing partner
Brendan McCorry, a 34-year EY veteran, takes over as Boston managing partner, replacing Jane Steinmetz, who was promoted to lead the firm's Northeast region.
Trump administration gave firm with ties to ballroom donor the green light to do business with a sanctioned Russian bank
Private equity investor Konstantin Sokolov was also appointed to run a government enterprise fund.
Bham firms trade Hoover apartments for $7M
A Birmingham-based firm flipped a Hoover apartment property after nine months of new management and renovations.
Bergen New Bridge, Ramapo College partner to bolster state’s health care workforce
Bergen New Bridge Medical Center and Ramapo College are expanding their partnership to bring more students into real-world clinical settings.
Made in Arizona: Cactus Corn bets on partnerships, tourism for sustained growth
Phoenix-based popcorn brand Cactus Corn expands beyond Chase Field with retail partnerships and corporate gifting to diversify revenue streams.
AT&T's $1.35 billion Plano headquarters moves closer to construction with final site plan vote
AT&T's $1.35 billion Plano headquarters nears final approval, while Dallas considers renaming a street for the Texas Stock Exchange's new home.
Screen-led reformer Pilates studio to open in Ybor City mixed-use development
Virtulates Studios opens its first location in Ybor City with a screen-led Pilates concept designed to keep membership costs lower and offer flexible class times.
J.K. Dobbins logs 10 carries
Denver Broncos RB J.K. Dobbins ties for team lead in carries against Jacksonville
T.J. Hockenson totals three receptions
Minnesota Vikings tight end T.J. Hockenson ended up with three receptions for 29 yards in Week 2
Preller Was Big Difference-Maker In Diamondbacks vs. Padres
The San Diego Padres had big needs at the trade deadline, and GM A.J. Preller came up big to meet them.
Cap Times Idea Fest: Two stories of a seafaring heroine
Forward Theater’s Jennifer Uphoff Gray moderated a “love fest” between Tilar J. Mazzeo and Erica Berman, who both wrote about an extraordinary journey.
A.J. Terrell leaves Week 2 game early
Falcons CB A.J. Terrell leaves game after suffering groin injury
Justin Verlander Set to Make Final MLB Start
Justin Verlander is targeting Saturday against the Pirates for the final MLB start of his legendary career, according to A.J. Hinch.
Why politicians should pay more attention to the polls (reprise)
Welcome to the 231st edition of The Week in Polls (TWIP), a polling newsletter that always welcomes new readers. So please don’t keep TWIP a secret; share it with your friends and colleagues: Share The Week in Polls With all the stories swirling around Reform, JL Partners and political polling, I am finally tearing myself away from talking about the regulation of polling this week - and instead re-running a previous piece reminding us why the solution to problems with polls isn’t simply to ban or ignore them. Rather, we need them to play a vital role in making our politics - and politicians - better. This is followed by summaries of the latest national voting intention polls, seat projections from MRPs and the most recent party leader ratings. Subscribers who pay for the full edition can also read ten insights from the latest polls and analyses, including: A trio of organisations and a pair of professors have been casting their eyes over the Liberal Democrats ahead of the party’s autumn conference; What impact did the summer heatwave have on views on climate change? and Which wins out between chocolate and cheese? If you are not yet a paid subscriber, you can read all ten by starting a free trial now: Get FREE 7-day trial For more polling news as it comes in ahead of next week’s edition, you can also follow The Week in Polls on Bluesky. Picking up on my doubt last week about whether or not 35% of British train travellers have tried to order a takeaway for delivery to a railway station or carriage, thank you to reader Iain, who has been in touch to say he has done just that… in India. Another quick pair of updates, this time on the controversies around Reform and polling. Politico has a further scoop - “Farage aide caught in donor sting attended Egypt retreat with JL Partners” - and Ian Dunt has written about the problems with polling too: “Seeing the response of many polling experts in the last few weeks suggests that they are nervous about what is happening and keen to mitigate against it. Seeing the response of journalists, which has been basically non-existent, suggests the precise opposite.” My usual reminder as well: please do hit reply if you’ve spotted a poll, focus group or new piece of poll-based research that you think should be in contention for coverage in a future edition. Thank you! And with that, on with the show. How politicians get public opinion wrong I have written before about the benefits that come from widespread availability of high-quality political polling. We need more polls and more good coverage of polls. However, what I’ve not dug into before is the research into how accurately politicians estimate public opinion on issues. Thankfully we have academic research to tell us. First, the bad news: We present results from a study of 866 politicians in four countries.1 Politicians were asked to estimate the percentage of public support for various policy proposals. Comparing more than 10,000 estimations with actual levels of public support, we conclude that politicians are quite inaccurate estimators of people’s preferences. They make large errors and even regularly misperceive what a majority of the voters wants. Politicians are hardly better at estimating public preferences than ordinary citizens. Walgrave, S., Jansen, A., Sevenans, J., Soontjens, K., Pilet, J.B., Brack, N., Varone, F., Helfer, L., Vliegenthart, R., van der Meer, T., Breunig, C., Bailer, S., Sheffer, L. & Loewen, P.J. (2023a), “Inaccurate Politicians: Elected Representatives’ Estimations of Public Opinion in Four Countries”, The Journal of Politics, 85(1): 209-222. The bad news is not quite as bad as that makes it sound because, when asked whether the majority of public opinion was for or against various policies, politicians picked the wrong option ‘only’ 29% of the time. However, this included getting it wrong even when public opinion is far from evenly split on an issue: They do not only get it wrong when the public is divided and hard to read (e.g., when there is a 51%:49% distribution). Seventy percent of the misplacements occur for policies with a relatively clear distribution of at least 60% (dis)agreeing citizens. Moreover, the public scored only slightly worse than politicians, picking the wrong option 2.7 out of 8 times on average, compared with 2.3 times for politicians. Turning to the other measure of accuracy (not which side is in the lead but what the percentage support is for each side), politicians on average were 18 percentage points out in their guesses. Again, this was only slightly better than the public, whose error came in at 21 percentage points.2 Further research, using the same mix of countries, gives a little more comfort about how (in)accurate perceptions are: We show that politicians have a better understanding of public opinion when they think the issue matters to voters. Further, when an issue is personally important to politicians they more accurately estimate their party supporters’ opinions. The results confirm that politicians hold more accurate perceptions of voters’ preferences when they think it is important to do so but not necessarily when the issues actually are important to voters. Butler, C., Walgrave, S., Soontjens, K. & Loewen, P.J. (2024), “Politicians are better at estimating public opinion when they think it is more salient”, Party Politics: 1–13. Even so, it’s not a good picture. The remedy for this? Politicians should spend more time reading the polls. So forward this newsletter to someone you know… Share For a more general argument against banning polls, see my 2024 piece. Is “Let Bartlet Be Bartlet” good advice or not? The latest episode of my Political Fictions podcast heads across the Atlantic for a dip into one of the political TV classics: Mark and Cory talk about a giant of American political drama for the first time this week, as they tackle The West Wing. They talk about Let Bartlet Be Bartlet, the nineteenth episode of series one. In it, Mark wonders if The West Wing is actually the epitome of the “Boris Johnson school of politics”, Cory outmanoeuvres Mark into confirming we will record a Christmas Special about Love, Actually and they debate whether the central message of this episode has been misunderstood. Cory’s email newsletter is Paperback Rioter and Mark has a family of email newsletters. Subscribe to our newsletter for some additional bonus content and to get alerted whenever a new episode comes out. Our theme tune is “Monkeys Spinning Monkeys” by Kevin MacLeod/incompetech.com and licensed under the Creative Commons: By Attribution 4.0 License. You can also listen to our episode on Apple Podcasts, Spotify, the web or YouTube. Elsewhere from me… [ A Lord's Eye View How to fix the problem of money in our politics Welcome to my latest update on work in the House of Lords. This time I am taking a look at how our political system is regulated, and the protections we need to keep democracy safe from becoming simply a contest to see who has the biggest bank account… Read more 5 days ago · 3 likes · 2 comments · Mark Pack ](https://lordseyeview.substack.com/p/how-to-fix-the-problem-of-money-in?utm_source=substack&utm_campaign=post_embed&utm_medium=web&embedding_publication_id=1269283) If you spot a factual error… Borrowing an idea from Stuart Ritchie and others, if you spot a factual error in an edition of this newsletter, I will give you a free 12-month subscription to the paid-for version (or an extra 12 months on your existing one). Factual errors qualify, but grammatical errors or disagreements over interpretation do not, and my decision is final. Messages about both of those are always welcome, though. Voting intention and leadership ratings Here are the latest voting intention polls from different pollsters. It is all pretty static at the moment, with a small and consistent Labour lead in nearly all the polls. The table is also online here, along with explanations about what is included. It is updated regularly throughout the week as new polls are released. Next are the seat projections from MRPs, also sorted by fieldwork dates, listing those which are based on dedicated fieldwork (rather than models based on averages of other polls). Because such MRPs are published infrequently, some of the entries below are quite old. Finally, here is a summary of leadership ratings, with a graph from PollCheck: Detailed numbers from the latest polls are online here, and both that and the graph are updated regularly throughout the week as new data comes out. For historical figures on both voting intention and leader approval stretching back to the 1930s, including Parliamentary by-election polls, see PollBase. Catch up on the previous two editions [ ](https://theweekinpolls.substack.com/p/a-crisis-point-for-political-polling) [ A crisis point for political polling Sep 13 ](https://theweekinpolls.substack.com/p/a-crisis-point-for-political-polling) [ Read full story ](https://theweekinpolls.substack.com/p/a-crisis-point-for-political-polling) [ ](https://theweekinpolls.substack.com/p/extra-questions-about-the-polls-in) [ Extra questions about the polls in Reform’s funding scandal Sep 6 ](https://theweekinpolls.substack.com/p/extra-questions-about-the-polls-in) [ Read full story ](https://theweekinpolls.substack.com/p/extra-questions-about-the-polls-in) My privacy policy and other legal information are available here. Links to purchase books or other items are usually affiliate links which pay a commission for each sale. Quotes from social media messages are occasionally lightly edited for punctuation and clarity. If you are subscribed to other email lists of mine, please note that unsubscribing from this one will not automatically remove you from the others. If you wish to be removed from all my lists, simply reply to this email to let me know. A quintet of Lib Dem polling analyses, and 9 other polling insights you shouldn’t miss The following ten findings from the most recent polls and analyses are only for subscribers who pay for the full edition, but you can sign up for a free trial to read them straight away. Ahead of the start of Liberal Democrat conference, we have a trio of organisations and a pair of professors with pieces out about Ed Davey’s party:
Patroits vs Steelers: Why is AJ Brown not playing today?
A.J. Brown will miss the New England Patriots’ Week 2 matchup after suffering a high-ankle sprain in his debut.
Marketing Daily: AI Visibility Sources Vary Widely By Health Category: Report
To gain more visibility in AI search results, health & wellness CPG brands need to focus on different content strategies depending on product category,
A big deal for Generac, a new public market, and more Milwaukee business news
Milwaukee Business journal editor-in-chief Tim Gibbons talks with WTMJ's Adam Roberts about a big deal for Generac, a new public market in Brookfield, and
Is ‘Monster’ star Ella Beatty related to actor Warren Beatty?
Ella Beatty plays the titular character in Netflix's 'Monster: The Lizzie Borden Story'
‘Sweet Magnolias' Creator Breaks Silence on Show's Shocking Cancellation
Sweet Magnolias creator Sheryl J. Anderson just broke her silence after the show's shocking cancellation.
‘Sweet Magnolias' Creator Breaks Silence on Show's Shocking Cancellation
Sweet Magnolias creator Sheryl J. Anderson just broke her silence after the show's shocking cancellation.
‘Sweet Magnolias' Creator Breaks Silence on Show's Shocking Cancellation
Sweet Magnolias creator Sheryl J. Anderson just broke her silence after the show's shocking cancellation.
Seafood Festival, Pensacola Beach Brawl among this week's big events
Seafood Festival, Pensacola Beach Brawl, Lionfish Invitational, and the Fall Big Book Sale are among this week's biggest events.
Steelers vs Patriots prediction: T.J. Watt, defense will flummox Drake Maye again
The Steelers forced five turnovers in beating the reigning AFC champions at Gillette Stadium almost exactly a year ago.
‘Sweet Magnolias’ Creator Reacts to Netflix Cancellation: ‘I Hope Serenity Will Always Have a Place in Your Heart’
Following the news that “Sweet Magnolias” has been canceled at Netflix, creator and showrunner Sheryl J. Anderson is looking back on the romantic drama’s 5 Season run. “Living in Serenity for five sea...
Marketing Daily: AI Visibilty Sources Vary Widely By Health Category: Report
To gain more visibility in AI search results, health & wellness CPG brands need to focus on different content strategies depending on product category,
Popular Florida cafe chain coming to Mass. for first time
Pura Vida Miami opens its first Massachusetts location in Harvard Square on Oct. 22, expanding the Florida-based wellness café brand into New England.
Patriots underrated WR viewed as Week 2 fantasy football sleeper
Patriots wide receiver Mack Hollins could be in line for a large workload in Week 2 with A.J. Brown sidelined.
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping its competition with various other consumer wearable sensors. These “readiness scores” as a composite of multiple metrics, with heart rate variability (HRV) being front and center for most. The majority of Americans are now using wearable sensors, which equates to well over 100 million adults. HRV and Readiness scores are increasingly being marketed as a measurement of autonomic nervous system health, a digital marker for future disease, a clock for biological age, and a holistic metric to promote healthspan and even longevity. (Apple also introduced a new longevity tab and “Health Age”.) None of this has been proven. In this edition of Ground Truths I am going to review what we know about heart rate variability and readiness scores. Heart Rate Variability HRV is the variation in normal heart cycle timing. The variability of the heart rate, the barely perceptible millisecond changes in time between consecutive heart beats (see R-R intervals in the Figure below, left panel), is due to interplay between the sympathetic and parasympathetic (vagal nerve) inputs. Distinct from heart rate, individuals with the same heart rate can have very different HRVs. It is a rough reflection of the autonomic nervous system (ANS) activity, inadequate to say whether a person’s ANS function is abnormal. For more than three decades, heart rate variability (HRV) has been measured and several studies have found an association of low HRV and clinical outcomes, particularly a link with higher all-cause and cardiovascular mortality. There have also been less well established links of low HRV to risk of early cognitive impairment, dementia, mental illness, Type 2 diabetes and substance abuse. An important reminder is that HRV is a surrogate marker without any established cause-and-effect relationship. If you increase your HRV, that doesn’t mean it will improve health outcomes. In fact, there is no hard evidence for that. All that work linking to health outcomes was done with electrocardiogram (ECG) derived HRV. Now, in the era of consumer wearables, this is getting assessed differently, by optical pulse (yes, the lights you see) plethysmography (PPG) or what is called pulse rate variability (PRV). They are not the same, as shown below (right panel) and only concordant when the delay between the ECG and pulse is kept constant, which basically means at rest. I should mention there’s also what I will call MPV, a mattress mechanical movement sensor, a derived heart rate variability, that companies like Eight Sleep use, even further away from directly measuring HRV. HRV has not one uniform measurement but many different types of quantification, such as RMSSD, the magnitude of difference between successive R-R intervals of normal sinus beats (N-N) or SDNN, the standard deviation of NN intervals, both in milliseconds. SDNN is one of the so-called frequency domain HRVs (others are LF, HF, LF/HF). Different wearable sensors use different metics; Apple has relied on SDNN and nearly all of the others use RMSSD, which is generally considered the more accurate metric. There’s also the different length of time measured, such as for a matter of minutes, all day, or an overnight’s sleep. Short measurements are especially problematic since they don’t capture enough of respiratory modulation and other factors that influence HRV. Share Ground Truths How well does HRV correlate with PRV? There are very limited studies, especially independently done. One that is commonly cited was conducted by Air Force researchers in only 13 healthy adults assessing Oura ring 3 and 4, Whoop 4.0, and Garmin Fenix 6 and showed a correlation coefficient of 0.88 to 0.97 and a mean absolute percentage error from 6 to 10%. The correlation is not a perfect 1.0, but there’s at least a fairly high level of correlation. HRV is supposed to increase during the night due to takeover of the parasympathetic nervous system, and higher during deep sleep. A recent example of my 1 week, all day “HRV,” and one during sleep is shown below. As you can see, the N of 1 data are inconsistent for the same days from different sensors (Oura, AppleWatch, Fitbit Air, and Eight Sleep) by patterns, absolute numbers, and comparison with prior days and weeks. The largest study in over 8 million Fitbit users (the old version, not Google Fitbit Air, introduced in May 2026) gives you a sense of the effect of age, sex, and the 2 different main HRV (here PRV) metrics, with RMSSD on the left and SDRR (=SDNN) on the right below. That study, from data collected in 2018, is a major outlier, since all the more recent ones are tiny with respect to sample size. Many of the companies have not had independent evaluation of their HRV, such as Eight Sleep, but have published a low standard error on their website. There are some other published studies on the correlation between HRV and PRV, but they are all small and only in healthy adults. A scoping review emphasized the lack of study in underrepresented individuals, including the aged, people of color (which affects the PPG signal), and individuals who are underweight or obese. Add the typical adult age 60 plus with one or more chronic diseases. For example, one study in over 900 adults found poor correlation of HRV and PRV, non-uniformly underestimated across many chronic diseases (cardiovascular, endocrine, neurological, respiratory, and others), concluding PRV is “an invalid surrogate for HRV.” A recent systematic review of 43 studies comparing HRV and PRV found reasonable pooled absolute standardized error (HRV as gold standard) but only 10 of the studies provided quantitative synthesis in ideal conditions. Their main conclusion was similarly cautious: “PPG-derived HRV [PRV] should not be regarded as universally interchangeable with ECG-derived HRV across all devices, populations, and recording contexts.” Factors Affecting HRV and PRV That gets me to the long list of factors that affect HRV (and PRV) besides the device, the type of measurement (RMSSD, SDNN or others), the person’s signal, the sensor site, the duration of data capture, if weighting by sleep stage is used, how artifact is processed and corrected. And this list is not complete!: Oura puts out data from their community of users (who input data) on what affects their overnight HRV. The factors currently provided are: no alcohol (increase 8%), melatonin (increase 2%, float tank (increase 2%), wine (decrease 4%), and party (decrease 14%) in overnight HRV. Must be some big parties! Subscribe What is a PRV measurement good for? It has been falsely characterized as an index of “autonomic balance” and a specific indicator of stress. A 2018 review of the studies available for HRV and its relationship to stress, not using any of the current wearables, found that stress can lower HRV. But so can many other factors. The non-specificity of the signal, indexed to the table above, is striking. Evidence from a UK Biobank study of over 46,000 participants with actual HRV looked at genetically predicted HRV, a genetic risk score, that failed to show the expected HRV-mortality link, indicating that _HRV is likely not causa_l, but rather a reflection of person’s physiologic state. A review of consumer wearable HRV data from 5 longitudinal studies showed that nighttime PRV was not associated with perceived stress, and surprisingly higher HRV, in the largest cohort (N=717 participants), was correlated with higher stress. An Oura ring cohort of 525 first-year college students found a link between overnight PRV and perceived stress, but that was also seen with resting heart rate, sleep, and respiratory rate. Several very small studies have examined the relationship of HRV and athletic injuries or guiding training with mixed, and predominantly negative results. HRV biofeedback training with paced breathing had no significant effect on reducing stress or raising HRV, as demonstrated with sham controlled trials. When HRV for multiple days showed a decline in conjunction with body temperature, the Oura ring published data for prediction of Covid. The WHOOP company sponsored an observational study, published in 2026, of 30,000 users for 72 weeks, without a control group, that reported reduced alcohol intake (5.8 % points) by self-report. That doesn’t tell us much, and particularly about the merits of HRV for behavioral change. If you use the same device and conditions as longitudinal trends for multiple (at least 2-3) weeks that may be the one way to get something useful from the measurements. Data for overnight sleep with minimal motion and using RMSSD is the best proxy for real HRV. The reason to look at trends rather than any given night is that it more likely represents something, even though you won’t know with certainty what the “it” is. Keep in mind there are no data, no peer-reviewed evidence, to show that HRV fluctuation in-person has any correlation with health outcomes. Share Readiness Scores These are proprietary scores that integrate different metrics for each of the wearables: no algorithms have been disclosed. They are unvalidated against health outcomes. In a review of 14 composite health scores of readiness and recovery, HRV contributed 86% to the scores, followed by reading heart rate (79%), physical activity and sleep duration (both at 71%). That review noted the substantial variability in measurement protools and lack of standardization. Sleep staging is notoriously inconsistent and inaccurate by these sensors, which adds further to the HRV uncertainties for what the scores, which use sleep stage data, mean. Only resting heart rate has been shown consistently across devices to be extremely accurate. I’ve made a Table to summarize what we know about which metrics are included, the scores, any peer-reviewed studies that compared the readiness score with health outcomes, and the corresponding (if any, NA-not available) citation. You will note that some companies do not use the term “readiness," such as WHOOP for recovery, and Garmin, which has 2 different scores, one of which is Body Battery. Eight Sleep uses the term “Fitness Score.” They all include HRV; Apple includes a new metric they call “Recovery HRV” which among other components uses 7-days of sleep, but it is unclear what this means or how it is differentiated from other scores (there are clearly no data for outcomes). We have no knowledge of how the different components are weighted or whether any of these scores are better than resting heart rate, HRV alone, physical activity, or any other single metric. Since none of these are standardized, they are not interchangeable, so if you get a 90 for Oura that has no relationship to a 90 on a Google Fitbit Air. Notably, the company can update its algorithm for readiness score at any point without notification to device users. Without any useful evidence of actionability for these scores or established relationship with health outcomes, it is hard to make a case for their value. At the Apple recent announcement they showed their Readiness score (0-10) on the watch (Figure below) but there are no published data on this score, not even on their website. It’s available only on their new Watch Series 12 or Ultra 4 [of course, ;-)]. That exemplifies the problems with these scores, lack of data and evidence for being meaningful to promote health. Perhaps the best study (which isn’t saying much) is the WHOOP Recovery for golfer performance, because it did correlate with an objective outcome, even though there was no control group and the authors were all from the company. Among the 389 pro golfers, an absolute 10-per cent point increase in Recovery score was associated with about 0.5 fewer strokes per round. But that’s hardly a health outcome! WHOOP is also conducting a study in over 2,700 runners to see if their recovery score will be linked to less injuries and improved performance, but that is not yet published and has no control group or randomization. Putting This in Context For two decades I’ve been enthusiastic about the potential for digital health and particularly wearable biosensors. Over the years, we’ve seen some great progress for their ability to promote physical activity and accurately detect atrial fibrillation (the first FDA cleared deep learning AI for consumers). That work was the subject of rigorous research. But there are holes in the data and evidence for other metrics. One notable one is the “VO2 max” story that I wrote about earlier this year. At that time many subscribers asked me to cover heart rate variability, which I finally got to here. When I dived into the research and publication for HRV and readiness scores, I expected to find at least some that were of high quality and demonstrated their utility by linkage to health outcomes. To my surprise, I found none. The wearable sensor measurements for HRV (PRV) are, for the most part, accurate, but that validation work has only been done in small studies of healthy adults and does not take into account the long list of factors, from the device, software side, and the user side, that affect HRV measurements. Moreover, this metric chiefly relies on optical sensing and, as we have learned for heart rate PPG sensing, may be less accurate in people of color. Keep in mind that all of the health outcome association evidence comes from ECG-derived HRV; none are from wearable sensor data. I will repeat the key point: there's no peer-reviewed evidence to show that in-person HRV fluctuation—or efforts to raise your HRV— has any correlation with health outcomes. For those of you who look at your HRV on awakening, or even 2+ week trends of it being low, I hope this context helps to relieve any anxiety. Yes, low HRV (not PRV) has been shown to increase risk of some diseases as summarized above. But efforts to raise your HRV—a surrogate metric— has not been established for improving any health outcomes. HRV does not have any evidence of causality (the genetic evidence actually goes against this possibility). In this summary, I have not included data for other wearable sensors such as Polar, Samsung, Withings, Suunto, Amazfit, Coros, Ultrahuman, or additional mattress sensors. These are beyond my first-hand experience, and as far as I know from my in-depth review none have any peer-reviewed published data that differ from the 6 sensors I’ve reviewed here. From the points I’ve gone over above, we’re not ready for readiness scores. Besides being proprietary, they are predominantly based on metrics that have their own issues. It’s compounding the problem, like building a house without a solid foundation that has never undergone a rigorous inspection, and then selling it. Like I mentioned for PRV, you can look at trends over weeks rather than any single day, to get a handle, but even that may not be helpful. There’s simply no evidence that these scores meaningfully relate to health outcomes. I’d emphasize they might, but that requires doing prospective or randomized studies to prove it. None exist. There’s great promise for HRV/PRV utility_. For example**,**_ Prof Maiken Nedergaard, who discovered the brain glymphatics that are essential in eliminating metabolic waste products from the brain during sleep, has posited that HRV could be a non-invasive marker for neuromodulator oscillations, brain-body regulatory circuits, and brain clearance. That would be extremely useful, but like everything else on HRV and readiness scores it requires solid research and validation. The lay media isn’t helping much to get the story straight. Earlier this year The Economist published a piece entitled “The most useful indicator of your overall health” which ordained HRV as an “accumulated stress score.” That’s akin to the false assertion about VO2max: “V02 max is the singular most powerful marker for longevity.” As I’ve summarized here, that is not established. The fact is that so many things can lower HRV, including physical exercise (especially an intense workout), reduced sleep quality, stress, the list above, no less the device, signal, and software. Whatever fluctuations observed have not been correlated with any health outcome. Sadly, “datamaxxers” are widely using HRV and readiness scores that have never been validated to mean anything. We already know that for some people using the sensors for sleep metrics, it can induce “orthosomnia,” an obsession to get high sleep quality, with associated high levels of anxiety. In an experiment done by a company to promote sleep quality for its employees, “For those employees who did use the trackers, many reported feeling perfectly rested until their tracker told them they had had a terrible night. Others were told that they had slept like a baby when they had actually been lying awake worrying about the quality of their sleep. “ The same problem can result from preoccupation with HRV or readiness scores, with anxiety that would lead to further reduction in both. It you are using a wearable like >100 million American adults, it’s OK to look at these data, but contextualized with the major caveats reviewed here. If you are one to require evidence that HRV or readiness scores are linked to health outcomes, you may not even want to look. The companies make it hard to turn them off! Let me end with the companies that make and sell wearables. Apple’s doubling down on HRV (24-fold more reporting and heart rate very 5 seconds) and introduction of a Readiness score tells us that consumers have bought into these metrics and they are joining the club. However, all of this is occurring with a backdrop of tens millions of users, claims about the data that are not backed up by adequate evidence, marketing way out in front of whatever limited data exists, and not being transparent about their readiness score algorithms. The companies can well afford to do the research that is needed to connect these metrics with health outcomes show, once and for all, that increasing HRV or using readiness scores promotes our health. If they believed and invested in the products they are selling, we’d not be in this position of not knowing. That’s essentially where we are with HRV and readiness scores. Perhaps someday this will change and we’ll have good reason to embrace them. NB: I wrote this post. No AI. I have no conflicts of interest with any of its content. Loading... Ground Truths has 215,000 subscribers from every US state and 214 countries. There are over 300,000 followers of Ground Truths so more than 90,000 folks who can easily convert to be free subscribers. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. If you’re not a subscriber, please join! If you found this interesting PLEASE share it! Share Ground Truths The proceeds from all voluntary paid subscriptions go to support our summer internship program. It enabled us to accept and support a record number of 62 summer interns that joined us in 2026! These are high school, college and medical students selected from thousands of applicants. We couldn’t do this expanded program without the funds coming in through Ground Truths. Thank you!
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