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Cleveland Guardians’ Rookie Kahlil Watson Flashing Major League Tools
Cleveland Guardians rookie outfielder Kahlil Watson has shown power, speed, a good hit tool, and solid defense after his graduation to the major league club
Survey shows Japan's business sentiment improving for a 5th straight quarter
TOKYO (AP) — Business sentiment among major Japanese manufacturers has improved for a fifth straight quarter, the Bank of Japan said in its quarterly “tankan” survey released Wednesday.
Survey shows Japan's business sentiment improving for a 5th straight quarter
The Bank of Japan has reported its quarterly survey of business sentiment among major Japanese manufacturers rose to 22 in June from 17 in the previous quarter
Survey Shows Japan's Business Sentiment Improving for a 5th Straight Quarter
TOKYO (AP) — Business sentiment among major Japanese manufacturers has improved for a fifth straight quarter, the Bank of Japan said in its quarterly “tankan” survey released Wednesday. The survey's so-called diffusion index rose to 22 from 17 in the previous quarter, the BOJ said. The index for ...
How Elite Sports Coaches Make High-Pressure Decisions
Drawing on interviews with 11 elite coaches across major U.S., European, Australian, and New Zealand professional sports leagues, the authors show that high-pressure decisions aren’t a single “formula” but a set of practices that unfold before, during, and after pivotal moments—and translate directly to business leadership. Top coaches combine disciplined preparation with emotional control and social awareness during crunch time and accountability and continual system improvement after the fact.
Central College to offer data science major
Central College will begin offering a new degree program this fall aimed at preparing students for data-focused professions across a number of industries. The Pella private college announced in a
Trump shifts strategy after major defeat on birthright citizenship
Donald Trump's crypto income tops $1B, financial disclosure reveals
Donald Trump's 2025 financial disclosure revealed major crypto earnings, with World Liberty Financial and memecoins leading the way.
NH Institute of Politics Releases Major June 2026 Survey of NH Voters
The New Hampshire Institute of Politics at Saint Anselm College released its 90-page June 24-25, 2026 Survey of New Hampshire Registered Voters on Tuesday, detailing the survey results of how candidates are faring in the major races along with the mood of New Hampshire voters.
Program looks to help with cost of childcare in New York
Major counties are seeing multimillion-dollar boosts.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Local A/C company sees major uptick in business with excessive heat
Those at HD Air are working full throttle
Supreme Court agrees to review ban on AR-style semi-automatic rifles in major Second Amendment case
The Supreme Court announced Tuesday that it will decide whether cities and states may ban people from owning AR-15 rifles and similar semiautomatic weapons, taking up a major Second Amendment dispute that it had previously declined to address.
I Tried Sony's $260 Wearable AC. Here's Why I Turned Around Before Leaving the Block
Sony's Reon Pocket Pro Plus delivered on its promise of keeping me cool—but one major flaw made wearing it in public surprisingly difficult.
NC budget includes UNC, NC State athletics for sports betting tax distribution
The state’s two major universities were left out of the previous model, which provided tax revenue to college athletic programs.
Report: Apple Watch Redesign Coming Next Year With New Band System
A "major overhaul" of the Apple Watch's design is due to arrive next year with a new system for connecting bands, according to a known Weibo leaker. In a set of recent posts, the leaker known as "Instant Digital" linked the new claim to older rumors about an "Apple Watch X" model, which was said to introduce a fresh design and break compatibility with the existing watch band system.
Apple Watch to get ‘major overhaul’ next year, says leaker
Apple Watch Ultra 4 is rumored to have major design changes, and per a new leak, the ‘Series’ line could get its own big upgrades next year.
Supreme Court upholds bans on transgender athletes participating in women and girls' sports
Justice Brett Kavanaugh, who has long coached his daughters' and other girls basketball teams at school, wrote the court's majority opinion.
Supreme Court upholds state bans at center of transgender sports debate
WASHINGTON – The Supreme Court upheld state bans on transgender athletes, a ruling with major implications for Arizona and 26 other states with laws restricting participation in school sports.
Strengthening Collaboration between Workforce, Health, and Human Services to Meet New Federal Requirements
Human Services Policy Advisors Institute | June 24th, 2026 H.R. 1, or “The One Big Beautiful Bill”, introduced significant changes to work requirements across major health and human services programs. including expanding the populations subject to SNAP time limits, reducing state/territory SNAP waiver flexibility, and creating new work requirements in Medicaid. These changes accelerate the […]
Argonne Open House 2026: Science comes to life for visitors
Argonne’s June 27 Open House welcomed more than 8,000 visitors for hands-on science, tours of major research facilities and opportunities to meet researchers across four themes: AI, energy, scientific tools and the universe.
Leading Colorado toward modern mental health solutions
By Sean Camacho America is facing a silent crisis. Millions of Americans are living with invisible illnesses like generalized anxiety disorder (GAD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD), which decrease quality of life and, amid limited treatment options, create a vicious cycle of endless medications and, for many people, hopeless therapies. This […]
CNN Host and Chief Legal Analyst Laura Coates, breaks down the major rulings by the Supreme Court on presidential power.
Scientists say creatine may help fight depression
Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply. A new review examined five randomized clinical trials involving 238 participants and found mixed results. Two studies, both involving women with major depressive disorder, reported that adding creatine to standard treatment improved symptoms, while three others found no meaningful benefit.
Not many ‘Iron Men’ are left in Major League Baseball
Pete Alonso played his 500th consecutive game this week, although if he wanted that to seem impressive to local fans, he probably picked the wrong city to play in. Alonso, of course, joined the Baltimore Orioles this past offseason. Their franchise record for consecutive games is also the big league record of 2,632 by true […]
Meta Summer Sale Offers Massive Savings On Hundreds Of Quest Games
Meta Horizon Store's "Peak Summer Sale" is on, offering major savings on hundreds of Quest, games, apps, and DLC. Here are some of the best deals.
Private Equity-Backed IT Business TPx Files for Bankruptcy to Sell Assets
The managed information-technology services company has a restructuring agreement with its sponsor and the majority of creditors.
The Supreme Court handed Trump an election case defeat. Is a bigger win for him coming?
The Supreme Court’s ruling letting more than a dozen states keep their post-election grace periods for mail ballots is a defeat for President Donald Trump and Republicans ahead of the midterms, but the GOP can still capture significant victories in major election-related cases coming farther down the pipeline.
[8-K] ALLIANCE ENTERTAINMENT HOLDING CORP Reports Material Event
Alliance Entertainment Holding Corporation reports that majority stockholders delivered a written consent on June 24, 2026 approving a major charter change.
Will Andy Burnham’s economic vision make us all better off?
Andy Burnham has made his first major speech since returning to Westminster. He set out his vision for a No10 in the North, for more council house building and repeated his claim that Westminster was “broken”.
From mail voting to firings, SCOTUS verdict on Trump agenda is mixed
The Supreme Court dealt the Trump agenda major blows on economic regulation and mail-in voting, but also expanded Trump's power over federal agencies.
Pixel Watch 5 Just Got Major Confirmations
Google's new Pixel Watch 5 lands at FCC, confirms connectivity, satellite SOS, several sizes, and clues us in on release date.
Supreme Court issues opinions
Major rulings are anticipated this week in cases involving presidential power, birthright citizenship and transgender rights.
The Fleet Science Center just got a major upgrade
There are more interactive exhibits, a free entry gallery and a new cafe.
Central College to offer data science major this fall
Central College will offer a new data science major starting this fall, bringing together STEM, social sciences and humanities teaching.
UK software sales chart for the week ending June 27, 2026 - Star Fox tops the charts, outperforms Star Fox Zero and Star Fox 64 3D
The latest UK software sales chart for the week ending June 27, 2026 is now available. Star Fox was the major release of the week, and it seems to have done pretty well. For one thing, it took the top spot. We’re also hearing that the Nintendo Switch 2 game sold almost double what Star Fox Zero did during its...
Central Florida Congressional races attract out-of-district candidates
After long-time U.S. Representative Daniel Webster announced his retirement in April, potential successors quickly filed to run for the open Central Florida seat. But of the eight major-party candidates who
Why Rock Ya-Sin Is Poised to Replace Terrion Arnold
No matter what happens in court, the Lions have a major problem to solve—and Rock Ya-Sin may be the biggest beneficiary.
🚨 BREAKING: Robert Lewandowski agrees multi-year deal with Chicago Fire
Major League Soccer looks set to add another iconic veteran presence to its ranks this summer, with Polish legend Robert Lewandowski reportedly primed for a move to Chicago Fire.Per The Athletic, the ...
El Niño Is Back—and It Could Cost Businesses Trillions. What Smart Leaders Are to Prepare
Dartmouth research makes the duration of the damage clear: economic losses from major El Niño events persist for five years after the event itself.
Apple working on M7 Ultra Mac Studio for 2028 with potential major upgrade: report
Later this year, Apple will be debuting an updated version of the Mac Studio with M5 Max and M5 Ultra...
Major PS5 Feature Down for the Last 2 Weeks, Sony Silent
A widely used PS5 feature has been down for the last two weeks on both the console and the PS App, and there's no sign of a fix.
Americans now live longer in Democratic-held House districts. Here’s why
Even as health care issues rise in the 2026 campaign debate, new data show that far more House Republicans than Democrats represent districts where the most residents face major medical challenges — and lack health insurance.
Anaheim Ducks help Wisconsin Badgers extend major NHL draft milestone
This weekend's NHL Draft marks 29 straight where the Wisconsin Badgers have had a player selected.
Could Ennis Rakestraw Save the Lions’ Secondary?
Terrion Arnold’s arrest has left a major hole in Detroit’s secondary. Could this finally be Ennis Rakestraw’s chance to prove he belongs?
USF marine labs race to rebuild after fire
The college is taking a major step in its recovery by fast-tracking the process of purchasing lab equipment.
TherapyGo Announces Milestone as AI-Powered Mental Health Platform Expands Access to Licensed Psychologists
BOCA RATON, Fla., June 27, 2026 (GLOBE NEWSWIRE) -- United Innovation Solutions LLC today announced a major growth milestone for TherapyGo, its ...
Madonna makes rare reveal of 1 major pop diva she was 'jealous' of
"I was like, 'I'll never be as beautiful as Kylie!'" she said.
Madonna makes rare reveal of 1 major pop diva she was 'jealous' of
"I was like, 'I'll never be as beautiful as Kylie!'" she said.
Madonna makes rare reveal of 1 major pop diva she was 'jealous' of
Madonna recently revealed why she was 'jealous' of Kylie Minogue, even though she wore a T-shirt bearing the 'Can't Get You Out of My Head' singer's name to the MTV Music Awards in 2000.
Disgraced Actor's MAGA-Coded Movie Trailer Just Dropped — And The Plot Is WILD
"Run Hide Fight: Infidels" comes almost three years after Majors’ conviction for assaulting his then-girlfriend.
Week in Politics: Trump and bipartisan housing bill, John Bolton; Democratic socialists
President Trump canceled a signing for major housing legislation, former National Security Advisor John Bolton pled guilty to mishandling classified documents, and Democratic Socialists made gains.
Disagreements between Supreme Court justices bubble into public view as major rulings loom
The Supreme Court is handing down major opinions at a rapid clip, but even with some of the biggest decisions yet to come there are signs of tension between the justices.
‘Under the Radar’ Cowboys Free Agent Predicted for Major Payday
Bleacher Report predicts Dallas Cowboys CB Cobie Durant could land a major payday in 2027 with a standout season. The post ‘Under the Radar’ Cowboys Free Agent Predicted for Major Payday appeared first on HEAVY.
Why JD Vance is downplaying Richard Nixon’s corruption
It’s not every day that you see the would-be frontrunner for a major party’s presidential nomination extolling the virtues of Richard Nixon and downplaying his corruption.
Two Yankees Pitching Prospects ‘Turning Heads’ in Minors This Year
The old saying is you can never have enough pitching, which the New York Yankees have apparently taken to heart. The Yankees have a stockpile of potential starting-pitching arms in the minor leagues, including Elmer Rodriguez, and two “head turning” prospects, Ben Hess and Chase Hampton. The Yankees lead the majors in team ERA (3.30) […] The post Two Yankees Pitching Prospects ‘Turning Heads’ in Minors This Year appeared first on HEAVY.
Cutting costs to move forward: SoFi State of Small business 2026 survey
SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.
Cutting costs to move forward: SoFi State of Small business 2026 survey
SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.
Gambling disorder diagnoses spike after states legalized sports betting
Researchers analyzed millions of electronic health records and found a major difference between states that greenlit sports gambling and those that didn’t.
Gambling disorder diagnoses spike after states legalized sports betting
Researchers analyzed millions of electronic health records and found a major difference between states that greenlit sports gambling and those that didn’t.
Alito’s testy reaction to Sotomayor underscores tensions at Supreme Court
When major rulings are announced, most Supreme Court justices practice a kind of studied impassivity. Then, there’s Samuel Alito.
Grand Theft Auto 6 demand may be so high it will "likely outstrip supply" this holiday season, a video game retailer warns
Speaking to The Game Business, a major senior games buyer has warned that stocks might not survive the spending frenzy this fall.
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
Mobile-first serialized storytelling is rapidly becoming one of entertainment's fastest-growing businesses.
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
While much of Hollywood was consumed by the streaming wars, Issa Rae was studying a different mode of entertainment thousands of miles away: microdramas. No stranger to creating a successful online s...
233-acre Franklin farm could become major youth sports complex
A Nashville Predators-operated ice rink and athletic facility could transform historic Franklin property.
This autism therapy is covered by many insurers. Why does the military’s plan restrict it?
Logan Cabiao started applied behavior analysis therapy for autism when he was 2. Several years later, TRICARE, the military’s healthcare program, imposed major coverage restrictions.
Supreme Court hands Trump major victories on his immigration agenda
In two ideologically spit rulings that could affect millions, justices say the administration can deport some migrants and turn others away at the border.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Takeaways: Supreme Court hands Trump massive wins on immigration agenda
The Supreme Court’s conservative majority delivered President Donald Trump a pair of significant affirmations of his immigration policy Thursday, paving the way for the administration to effectively remove more than 1 million people from the US and keep many others from entering in the first place.
Supreme Court sides with weedkiller Roundup, making some MAHA activists angry
Here's what to know about health concerns surrounding glyphosate and the weedkiller Roundup following a major Supreme Court ruling.
Americans Are Not Buying White House’s Trump Health Claims
New polling shows what a majority of Americans really think of the explanations about 80-year-old Trump.
Major blow for MacBook Ultra: Apple said to cancel M6 Pro and M6 Max
The Apple MacBook Ultra will either be released with the older Apple M5 Max, or its launch will be significantly delayed. This is because Apple is said to have halted development of the Apple M6 Pro and M6 Max in order to focus on the M7 series instead, which is expected to offer significantly stronger AI performance.
Supreme Court hands Trump two major immigration victories
Supreme Court rules migrants turned away at the border cannot apply for asylum and blocks TPS recipients from judicial relief in two major decisions.
Major part of student-loan repayment overhaul is blocked in court
A federal court ruled that the Education Department's proposed borrowing caps for advanced healthcare programs cannot take effect on July 1.
Federal court blocks Trump’s executive order limiting mail ballots
The ruling comes a month after another judge allowed Trump’s order to stand. The latest ruling sidelines major provisions of the order despite the earlier ruling.
Playing soccer can score major goals for heart and brain health
Seattle, June 25, 2026 — As the global soccer championship run by the Fédération Internationale de Football Association (FIFA) plays out on stages across the world this summer, catching a fever for football (as soccer is known outside the U.S.) may...
KUSTOM ENTERTAINMENT, INC. ANNOUNCES BINDING AGREEMENT FOR THE DIVESTITURE OF ITS VIDEO SOLUTIONS SEGMENT TO FULLY COMPLETE LIVE ENTERTAINMENT PIVOT
Transaction Structured to Provide Up to $5.5 Million plus 2,000,000 Warrants to acquire shares of common stock of Cycurion, Inc.; Follows Previously Announced Major Live Music Expansion Partnership with Gilley’s Park City OVERLAND PARK, KS, June 25, 2026 (GLOBE NEWSWIRE) -- Kustom Entertainment, Inc. (Nasdaq: KUST) (the “Company”), a live entertainment and music festival company, today announced it has entered into a binding agreement for the divestiture of its legacy video solutions division to
TikTok and YouTube are reinventing how young fans watch sports
Sports TV ratings and live rights fees are soaring, but professional leagues and broadcasters are facing a new battleground for young fans. Social platforms like TikTok and YouTube are claiming an increasing share of viewing hours among Generations Z and Alpha. Sports clips, highlights and creator content can introduce younger fans to professional sport, but how do the major players cash in?
Mets trading David Peterson signals major deadline reset
David Peterson was the first domino for Mets.
Closed-door outburst turns into victory for Trump’s Iran negotiations
Senate Republicans flipped to reject Democrats' Iran war powers resolution, handing Trump a key win as U.S.-Iran peace deal talks continue on.
Sports betting boosts viewership for top-watched World Cup matches, new data shows
World Cup fever is growing, and new viewership data shows some matchups are drawing far more attention than others — with sports betting playing a major role in
UNM Project ECHO Works Closely with World Health Organization on Disease Outbreaks
When a major disease outbreak occurs, the World Health Organization (WHO) calls on Project ECHO at The University of New Mexico Health Sciences Center to help support the transmission of accurate, timely health information to clinical health workers and...
Student From Des Plaines Wins National Science Foundation Award
Elmhurst University biochemistry major Hannah Cardenas, of Des Plaines, recently received a National Science Foundation Research Experiences for Undergraduates (NSF REU) award to participate in a 10-week summer research internship at the University of Texas at Dallas.
Netanyahu’s growing unpopularity, angering Trump, boosts Mamdani’s pro-Palestine candidates for Congress
Netanyahu faces criticism over Gaza and Iran, pro-Palestinian candidates score major victories in New York politics.
Potential vote could change alcohol rules in Bardstown Road entertainment district
A political effort is underway that could put the liquor status of the Bardstown Road entertainment district on the ballot this fall, a move that could bring major changes to businesses in the area.
Meta's Zuckerberg enters the prediction market arena
Mark Zuckerberg is launching his next major project: a betting platform modeled after Polymarket. The prospects for success are good, alarming experts.
A new paper argues Microsoft exaggerated its quantum claims a year ago
A peer-reviewed critique of Majorana 1 claims Microsoft did not conclusively demonstrate a working topological qubit. Microsoft disagrees.
Winners and losers emerge after socialist earthquake rocks NYC primaries
Mayor Zohran Mamdani's socialist slate swept NYC Democratic primaries, defeating incumbents like Reps. Espaillat and Goldman in a major shift.
Sony Pictures Invests in Cosm Dome Venues in Major Deal
Cosm venues feature a unique dome shape, delivering a fresh experience for live events and theatrical screenings.
Sony Pictures Invests in Cosm Dome Venues in Major Deal
Cosm venues feature a unique dome shape, delivering a fresh experience for live events and theatrical screenings.
Trump says he won't sign major housing bill until Congress passes SAVE Act
The president's announcement came at an awkward time for House Republican leadership, coming just as they were speaking at a press conference about the importance of the bill in addressing affordability.
GTA 6 Ultimate Edition Pre-Order Details Confirm Major New Gameplay Features, Giving Players A First Look At Safehouses And Custom Vehicles
The latest GTA 6 Ultimate Edition news reveals plenty of fresh gameplay details, including fishing, fencing, fixing up classic cars and much more.
Microsoft's claims over its quantum chip questioned in Nature article
The tech giant has consistently stood by its Majorana chip research despite scepticism from some experts in the field.
Trump cancels plan to sign major housing bill as he fights with Congress over the SAVE Act
Just hours before heading to Capitol Hill, Trump called the big, bipartisan housing bill Republicans hope to run on in the fall “of minor importance.”
Scientists catch classical space-time crystals moving like Majorana quasiparticles
A research team from Hiroshima University, the University of Colorado, and other collaborators have demonstrated that space-time crystals—exotic structures that, under external drive, loop endlessly through ...
A NASA satellite caught a giant tsunami doing something no one expected
A Pacific-wide tsunami triggered by a magnitude 8.8 Kamchatka earthquake gave scientists their first detailed satellite view of a major tsunami in motion. The observations revealed unexpected wave behavior and helped uncover a larger earthquake rupture than earlier models predicted.
Health professor to research AI’s impact on hiring people with disabilities
Erblin Shehu, who specializes in healthcare management, will join a major project funded by the U.S. Department of Health and Human Services.
Abortion rights fight underscores key themes in Maine’s U.S. Senate race
Four years ago today, the U.S. Supreme Court overturned Roe vs. Wade. In the majority of that decision was Justice Brett Kavanaugh, who Republican U.S. Sen. Susan Collins of Maine had voted to confirm after he had told her the landmark decision was “settled law.”