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Trump center stage at RNC in midterms gamble
President to give speeches on both days of unprecedented gathering
Apple’s (AAPL) “Surprise and Shine” Event Tests Its Foldable iPhone Against Huawei and Xiaomi
Wall Street sees Apple Inc. (NASDAQ:AAPL) entering a significant hardware cycle ahead of its “Surprise and Shine” event streaming live on Wednesday, September 9, 2026. Bank of America, in particular, expects a broad slate of new Apple devices led by new iPhones and a Foldable iPhone. On September 8, BofA Securities analyst Wamsi Mohan reiterated a […]
Commissioners consider multi-million-dollar contract for inmate health care
MEMPHIS, Tenn. — Shelby County commissioners are considering a massive multi-million-dollar contract for inmate health care. The contract would bring in a new medical provider for the county&…
Work starts on 16-acre indoor go-karting, arcade venue in Polaris
Supercharged Entertainment is marking its Midwest debut with a new go-karting concept in Polaris, slated to open in summer 2027.
Will Trump’s Midterm Convention Help or Hurt Republicans? 5 Things to Watch.
At an unusual gathering in Dallas, some of the party’s top candidates will be forced to decide just how tightly to tether themselves to an unpopular president.
Luminis cybersecurity incident highlights 'concerning' rise in attacks on healthcare
Cyberattacks on the healthcare industry, like the one that hit an Anne Arundel County hospital last week, are becoming increasingly common and state-level policymakers should prepare for even more, an expert said Tuesday.
Schumer and Jeffries opposed a Brooklyn power play. It happened anyway.
The Brooklyn party chair rewrote the rules ahead of a leadership vote despite objections from the nation’s two most powerful Democrats, and some in the party are wondering if they could do more to stop her.
Why does early treatment matter for psychotic episodes?
Early treatment for psychosis can improve recovery and challenge the idea that mental illness means a lifetime of suffering.
Volusia County business owner recovering after stabbing
Jessica and Count Foreman, co-owners of Saute Kingz in Daytona Beach, have temporarily closed their business following a violent incident involving their 23-year-old son, Jesshuan.
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ SK hynix Vice President Jaewuk Ju, head of the Smart Manufacturing Technology/AX Advance department, delivering the first keynote presentation
Packers’ 3 biggest concerns entering 2026 season
The offensive line is chief among the potential issues for the Packers as they enter 2026, with the health status of Zach Bako-Bewele still uncertain.
LeBron James is partnering with prediction platform Polymarket
PHILADELPHIA — Where LeBron James would choose to play the final years of his storied career was a fixture on prediction markets this summer. Now, James could benefit from the
Myles Garrett injury: Are 49ers catching another break vs. Rams?
The San Francisco 49ers aren't the only team dealing with injury question marks on their defensive line entering Week 1 vs. the Los Angeles Rams.
Netanyahu will make a quick trip to speak at the UN after Mamdani urged his arrest, diplomat says
Israel’s Prime Minister Benjamin Netanyahu is making a whirlwind 24-hour trip to speak at the U.N.’s annual gathering of world leaders this month after New York’s mayor urged his arrest over the war in Gaza, That's according to Israel’s U.N. Ambassador Danny Danon on Tuesday | WWJ Newsradio 950
Netanyahu will make a quick trip to speak at the UN after Mamdani urged his arrest, diplomat says
Israel’s Prime Minister Benjamin Netanyahu is making a whirlwind 24-hour trip to speak at the U.N.’s annual gathering of world leaders this month after New York’s mayor urged his arrest over the war in Gaza, That's according to Israel’s U.N. Ambassador Danny Danon on Tuesday | K-DAWN
Seahawks Announce Nick Emmanwori’s Final Injury Status for Patriots Rematch
Nick Emmanwori has spent much of the offseason recovering from offseason ankle surgery. Will he be able to suit up for the Seattle Seahawks in Week 1? The post Seahawks Announce Nick Emmanwori’s Final Injury Status for Patriots Rematch appeared first on HEAVY.
Vallejo’s Empress Theatre amps up entertainment offerings, dining
“The idea is simple: there should be something happening often enough that people throughout Vallejo, Solano County, and the greater Bay Area can make the Empress part of their regular week,” says the Empress Threatre.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Fashion, food and fun combine to make this event a success
arc THRIFT STORES Denver News: “Let’s Celebrate” was the theme for arc Thrift Stores’ annual fundraiser, and it’s not a stretch to say that’s exactly what everyone did at this Sept. 3 gathering held at Denver Botanic Gardens. The crowd that filled the gigantic tent overlooking the UMB Amphitheater launched the celebration with a social hour where good conversations, along […]
Flyers Confirm Major New Arena News
After nearly three decades of playing at the historic Spectrum in South Philadelphia, the Philadelphia Flyers and 76ers moved into Xfinity Mobile Arena (originally called CoreStates Center) in 1996.The upcoming campaign will the be 30th season that both teams call the venue home, but that won’t be the case much longer. Renderings have been released […] The post Flyers Confirm Major New Arena News appeared first on HEAVY.
Louisville opens first mental health crisis center
Louisville’s first mental health crisis center is now open, offering walk-in help and a new option beyond jail or the emergency room.
Shutterstock Appoints Three Accomplished Business Leaders to Board of Directors
/PRNewswire/ -- Shutterstock, Inc. (NYSE: SSTK), a family of brands delivering scalable creative and GenAI solutions to help customers fuel great work, today...
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
The Galaxy Z Fold 8 is outselling Samsung's record-breaking Fold 7 by a wide margin
Samsung finally explained the engineering behind the gap.
MAC appealing Michigan-Western Michigan result after 'further study'
Michigan football's game against Western Michigan is in the record books as a Wolverines win.
Owner seeks second extension for 683-unit Brookland project amid tough market conditions
Jack Sarf seeks another extension on his Franklin & Reed mixed-use development in D.C. as Hanover R.S. LP pulls out due to market conditions.
MAC reverses course, appeals Michigan win over Western Michigan
The MAC is appealing the Michigan vs. Western Michigan game result, claiming the Big Ten used incorrect replay protocol.
“Furious” creator breaks down season 1 finale and teases what’s next for Alice
“I’m definitely not using the show as a platform to advocate murdering people,” Meriwether tells EW.
‘Furious’ creator breaks down season 1 finale and teases what’s next for Alice
‘Furious’ creator Liz Meriwether breaks down the shocking finale and what’s next for the crime drama: ‘I’m definitely not using the show as a platform to advocate murdering people.’
NFL media hires two veterans as new analysts
NFL Media is bolstering its ranks ahead of the 2026 season with a pair of familiar names. The league’s media arm is undergoing a transition this season with NFL Network now under the umbrella of ESPN. That arrangement is part of the equity deal that now sees the league as a minority owner in the…
Will Toronto Blue Jays Slugger Anthony Santander Return This Season?
The outfielder/DH has missed the entire season after recovering from labrum surgery in the offseason.
AMP Sports Launches The Dark Side Podcast with Seattle Seahawks Super Bowl Champions Derick Hall and Byron Murphy II
SEATTLE – September 8, 2026 –Sinclair’s AMP Sports today announced the launch of The Dark Side, a new podcast featuring Seattle Seahawks Super Bowl champions Derick Hall and Byron Murphy II, alongside KOMO News Sports Director Niko Tamurian. Each week, The Dark Side will go beyond traditional game analysis, with Hall and Murphy offering a...
Dan Campbell Gives Kerby Joseph Update Ahead of Week 1
Kerby Joseph has returned to the Detroit Lions facility as he continues recovering from the knee injury that ended his 2025 season.
Scientists Discover the 7 Stages a Meteoroid Goes Through Before Hitting Earth
An analysis of 75 meteorite falls identified seven distinct processes that occur as space rocks melt, break apart, and slow down before reaching the ground. A space rock entering Earth’s atmosphere does far more than simply “burn up.” By examining 75 meteorite falls recorded in videos and photographs, researchers identified seven distinct stages that shape
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1
Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.
Here’s Samsung’s Advice for Apple and Its Upcoming Folding iPhone
The competition is “absolutely welcome” by the pioneering Korean giant, but Samsung warns that the device’s “weight” is crucial.
Michigan Football Film Room: Fixing the Run Game
Michigan Football escaped Western Michigan, but serious offensive concerns remain. We break down the Wolverines’ run-game struggles and what must improve in this week’s film study:
Award-Winning Photographers Give Newhouse Students Up-Close Look at Covering Sports
Sony Artisans of Imagery Jean Fruth and Patrick Murphy-Racey provide advice, lead workshops at Syracuse football, Syracuse Mets games.
What Formula One Engineering Can Teach Us About AI Infrastructure
Michael Fuller, Executive Chairman of Conflux Technology, examines why thermal performance alone is no longer enough in modern data centers, and how balancing heat transfer with hydraulic efficiency can unlock significant operational gains. The AI era is forcing data center operators to rethink some long-held assumptions about infrastructure design. As processor power densities continue to […]
Updated NFL Conference Championship odds entering 2026-27 season
Here's an updated AFC and NFC Championship odds entering the 2026 NFL season.
College Football Has Adopted the Western Michigan Broncos
The country has picked a side after Michigan's one-second Hail Mary, and it isn't the Wolverines. #WMU
Milan Keep Considering Appointing an Elite Director
Despite a couple of attempts, Milan didn’t bring in a new head of football in the summer and simply promoted from within after ousting CEO Giorgio Furlani and director Igli Tare. While Gerry Cardina...
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
SC's Emerging Biotech Industry Receives National Recognition
Genetic Engineering & Biotechnology News (GEN) recently named the Palmetto State among its “Regional and State Clusters to Watch” in its first-ever Next 10 U.S. Biopharma Clusters report, highlighting emerging life sciences ecosystems beyond...
Mark Consuelos injured during “Live With Kelly and Mark ”break as Kelly Ripa recovered from gum surgery
Consuelos revealed a sports-related injury sustained while “Live” was on a between-season break, during which Ripa was recovering from a painful oral procedure.
First Renderings Of New Philadelphia Arena Inspired By The Spectrum
Planned 2030 opening includes an outdoor plaza and opportunities for an expanded restaurant experience at the South Philadelphia location
TV Tinsel: Remembering the truly iconic Dolly Parton
If there’s one word overused in the English language, it’s “icon.” It seems that everything and everybody is an icon, diluting the reference by its casual use. But there is
Bailey Stockton reflects on special touchdown from Aaron Philo
Bailey Stockton discussed reuniting with Aaron Philo, scoring in his Florida debut and the Gators' offensive potential entering Week 2.
UT Researchers in Electrical Engineering and Computer Science Receive NSF CAREER Awards
Two researchers at the University of Tennessee, Knoxville, have received 2026 National Science Foundation CAREER awards.
Provident Behavioral Health Data Breach Exposes SSNs, Medical Info
Got notice about the Provident Behavioral Health data breach? Learn why lawyers are considering a class action suit and what you could be owed.
Why a cannabis business is betting on dogs to reach FDA approval
Endovia is pursuing FDA veterinary approval for its cannabinoid drug targeting canine cancer and chronic pain in the companion-animal market.
What Makes Guardant Health (GH) a Compelling Bet?
Artisan Partners, an investment management company, released its second-quarter 2026 investor letter for the “Artisan Mid Cap Fund”. The letter can be downloaded here. Global equities rebounded sharply in Q2 2026, recovering from March lows as resilient economic data, strong corporate earnings, and continued AI investment improved investor sentiment despite inflation concerns, delayed rate cuts, and […]
Nearly half of depression risk factors overlap with physical illnesses, especially gut disease
QIMR Berghofer researchers have identified a strong genetic link between gut-related health conditions and depression in a study offering new insights into why physical illnesses often accompany the mental ...
SkyWater Launches Quantum Semiconductor Manufacturing Business
SkyWater launched a dedicated quantum semiconductor business offering superconducting, photonics, and integration capabilities for customers.
Steve Flowers: Political reassurances and revelations in 2026
Faces and places and races change in politics, but one thing that stays the same is the candidate who has the most money for campaign advertising and vote gathering, nine times out of ten wins.
📺 Follow Roma’s Champions League journey live on NOW!
After seven years away, Roma are back in the Champions League. Gian Piero Gasperini’s Giallorossi are ready to test themselves against some of Europe’s best teams, including Real Madrid, PSG and M...
Tesla Sales In China Continue Negative Streak; Exports Reach Key Level
Tesla China is offering new cash incentives through Sept. 30.
Dodgers notes – Shohei Ohtani, Mookie Betts, Andy Pages
Shohei Ohtani returned to the Dodgers lineup on Monday night against the Cincinnati Reds after missing four games dealing with lingering issues. He looked much more like himself that he has in a while. He very likely will not return as a pitcher this season, however. The Dodgers are hoping that being able to just […]
Did California forget about its zero-emission school bus project?
“Considering the state’s requirement for all school buses to be zero-emission by 2035, more sustained statewide support is needed.”
Bausch Health and YUN Announce Expansion to Mexico and Across Additional EMEA Markets
/PRNewswire/ -- Bausch Health Companies Inc. (NYSE: BHC)(TSX: BHC), a global, diversified pharmaceutical company, and YUN, a Belgian innovator in pioneering...
Arena for 76ers, Flyers marks 'new era for Philadelphia sports'
The 76ers and Flyers have unveiled renderings of their new fully privately funded arena in South Philadelphia, which is targeted to open before the WNBA season in 2030.
Arena for 76ers, Flyers to open in 2030, marks 'new era'
The 76ers and Flyers have unveiled renderings of their new fully privately funded arena in South Philadelphia, which is targeted to open before the WNBA season in 2030.
La Compagnie Starts Business-Class Flights Between N.Y. and Düsseldorf
La Compagnie is launching a direct business-class service between New York and Düsseldorf in 2027, offering five weekly flights on an Airbus A321neo.
Business Beat : KCC offering CNA training in Battle Creek and Coldwater in November
BATTLECREEK, MI (WTVB) - Kellogg Community College is accepting applications now for 12-day CNA training cours...
Louisville tech firm V-Soft already seeing payoffs from its latest acquisition
V-Soft's acquisition of St. Paul-based Logisolve adds data and AI capabilities, helping the Louisville firm expand its technology consulting offerings.
Projecting Eagles’ defensive depth chart entering Week 1
Projecting Philadelphia's defensive depth chart for Week 1.
'The aim is to keep evolving'
Fan writer Paul Sullivan says Charlton Athletic fans should keep their feet on the ground after fast start brought to shuddering halt.
Hawaii County panel approves $90M Keaau Health Center
A Hawaii County panel has cleared the way for Hilo Benioff Medical Center to build an outpatient medical clinic in Keaau.
GOP’s Trump-led midterm convention comes to Dallas this week
The two-day gathering, informally dubbed “Trumpapalooza,” will put Texas at the center of the political world as it hits the homestretch of its most competitive election cycle in years.
‘You are not a bad mother’: transforming women’s mental health care during pregnancy and after childbirth in Armenia
The arrival of a baby is often seen as one of life’s most joyful moments. Yet behind the expectation of happy motherhood, some women experience anxiety, depression, fear or emotional distress – feelings that can remain hidden behind the pressure to be “a good mother”. In Armenia, a woman’s mental health during the perinatal period is still too often overshadowed by the focus on physical health. This gap was spotted by the Kanani Social-Prsychological Centre NGO, which used EU support to make mental wellbeing part of maternity care across Armenia. During the final months of her second pregnancy Lilit (28) was full of fears. Her
Why VCs are questioning AI companies' big revenue claims
Investor skepticism is growing around the revenue claims powering the AI boom.
Music legend considering leaving the U.S. because of Donald Trump: ‘I’m not aboard’
The eight-time Grammy Award winner made the revelation during a recent interview.
Complete Week 4 Gainesville area FHSAA high school football schedule
Wondering when your favorite team plays this Friday? Here is the Week 4 Gainesville area FHSAA and SSAA Gainesville area high school football schedule.
2,300 Roma fans expected for first Champions League match
The atmosphere in Istanbul will be heated. It won’t be an easy trip for Roma, but Gian Piero Gasperini’s team seems ready to face Fenerbahce among their fans, coming off a 2-1 defeat to Besiktas. ...
Lallemand establishes Solyve as dedicated food and beverage enzyme business
Lallemand has launched Solyve as a dedicated food and beverage enzyme business. The move follows Lallemand’s acquisition-led expansion.
Will Lampard change the way Coventry play this season?
Coventry City's style of play has been the subject of several questions sent in via our Sky Blues Ask Me Anything form, with some of you wondering whether Frank Lampard will adjust it this season as a result of facing higher-level opposition. Coventry's shape under Lampard is never fixed and that tactical flexibility is going to be a major theme of their Premier League return. The Premier League is unforgiving, stacked with world‑class players, and there will be times where a more conservative approach is simply the smartest route.
25 years ago, a NASA astronaut captured this haunting photo of the 9/11 attacks
During the Sept. 11 attacks, NASA astronaut Frank Culbertson — the only American not on Earth at the time — snapped a "sobering" shot of smoke pouring across New York City as the second tower fell.
Liverpool will activate magnificent £47m clause for sensational star
Liverpool are going to be buying another defender in the near future. Everything is gearing up for the departure of Virgil van Dijk. He is entering the final year of his contract at Anfield. Liverpool...
GenSight Biologics Provides September 2026 Business Updates
PARIS, September 08, 2026--Regulatory News: GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today provided business updates covering the summer of 2026 and confirmed the publication date for the Company’s financial statement covering the first half of 2026.
Remembering ‘Superstar’ Bill Dundee and his unlikely Owensboro furniture business
For a time, Owensboro wrestling fans could buy furniture from “Superstar” Bill Dundee — and have him help deliver it.
French A.I. Start-Up Mistral Raises $3.5 Billion as Part of Strategy Shift
Mistral is trying to keep pace with American and Chinese rivals while offering customers a European alternative for artificial intelligence.
Candidates offering healthcare slogans, not solutions: Dr. Ashish Jha
“There’s a set of things we can do to lower health care spending, but the slogans are not going to get there,” Jha said.
Paramount Weighs Assets Selloff to Save Deal
Paramount Skydance Corp. is reportedly considering selling off cable and real estate assets as it looks to settle a multistate antitrust lawsuit
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Corewell and healthcare firm to build Sterling Heights rehab hospital
The 84-bed hospital will be dedicated to patients recovering from stroke, spinal cord and brain injuries, amputations and some orthopedic conditions.
49ers announce decision on Nick Bosa amid health concerns
When he’s healthy, San Francisco 49ers star pass rusher Nick Bosa is one of the best pass rushers in the entire league. And despite questions about his health, it sounds like he’ll be ready to go for the team’s season opener. Bosa tore his ACL last season and has been recovering ever since. While he…
Ukraine war briefing: New political turmoil in Kyiv as prosecutor general resigns
Anti-corruption agencies raid offices and arrest a deputy of Ruslan Kravchenko in case linked to alleged laundering of phone scam proceeds. What we know on day 1,658
Michigan QB Depth Chart: Who is Bryce Underwood’s Backup?
Michigan Wolverines quarterback Bryce Underwood pulled off a miracle Saturday night against Western Michigan. Fans know the story by now. Underwood threw a Hail Mary pass out of bounds that seemed to give WMU the upset win, only for the officials to put one second back on the clock. The next pass was on target […] The post Michigan QB Depth Chart: Who is Bryce Underwood’s Backup? appeared first on HEAVY.
Mental health services being offered at two schools
Riverside Counseling LLC will begin providing on‑site mental health services at both Eisenhower and Youngsville Schools starting in the 2026 school year. The initiative aims to make emotional and behavioral health support more accessible for students by offering therapy directly within the school buildings. “We are here to support the Youngsville and Eisenhower Schools by […]
Two Orlando Magic Games Fans Should Circle
Not every Orlando Magic fan can make every game, so here are two worth considering next season.
Port of Grandview works to attract new businesses with active marketing and land development
The BriefThe Port of Grandview is actively marketing the community to attract new business development, with efforts including attendance at trade shows and conventions like Food Northwest in Portland.The Port reports strong demand for business property, with several prospective clients currently seeking space to build in Grandview.The Port recently acquired 45 acres for its new Woodworth Road Business Park, with planning underway to support the community's continued growth.GRANDVIEW — The Port of Grandview is capitalizing on strong interest in the community by actively marketing Grandview to businesses seeking locations for expansion and growth. The Port's efforts are paying off, with increased development activity and growing demand for available business property.Grandview's appeal stems from multiple factors. The community's available land and central location between the Tri-Cities and Yakima make it an attractive option for businesses looking to establish or expand operations. The Port has recognized these advantages and is taking a proactive approach to market the community directly to potential clients.Port Executive Director Randy Tucker says the Port has been actively attending trade shows and conventions to promote Grandview as a business destination. These events, including Food Northwest in Portland, provide opportunities to connect with companies actively seeking new locations."Say, hey, locate your business here and bring your customers here. And it's worked out pretty good for us," Tucker said.The Port's marketing strategy is generating results. The Port reports strong demand for business property, with several prospective clients currently looking for space to build in Grandview. This interest reflects the effectiveness of the Port's outreach efforts and the community's appeal to businesses in various industries.To support this growth, the Port recently acquired 45 acres for its new Woodworth Road Business Park. Planning is underway to determine how the property can best support Grandview's continued development and attract additional businesses to the area.The combination of available land, strategic location, and active marketing positions Grandview as an increasingly attractive option for businesses seeking to relocate or expand. As the Port continues its efforts to promote the community, Grandview appears poised for continued economic growth and development. News Three Queens Fire approaching 10,000 acres, now 11% contained Robert Desaulniers, Josh Culbreth News Two injured after rear-end crash leads to rollover near Grandview Robert Desaulniers News Grandview High School temporarily enters secure and teach for possible altercation between students Robert Desaulniers News Port of Grandview pursues economic growth with new business park development William Albert, Apple Valley News Now News Driver dies in fiery crash in Columbia Park Friday Erin Wencl COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Maura Higgins and Mark Ballas tease ‘Traitors’ costar Rob Rausch could join them on ‘DWTS’ (exclusive)
Maura Higgins and Mark Ballas revealed to EW that their ‘Traitors’ costar Rob Rausch will be cheering them on night 1 of ‘DWTS’ — and could even cameo in one of their dances later on.
City of Durango will move almost 30 employees to Axis Health building ahead of City Hall construction
Community Development and Engineering building faces demolition
First Responders At 9-11 Still Suffering From Health Problems
The toxic dust and debris from the collapse of the World Trade Center on Sept. 11, 2001 is still affecting many who lived and worked there.
Amazon Restocked the Rare Pokémon TCG Prismatic Evolutions Super-Premium Collection Directly, Offering a Chance to Chase the $1,500 Umbreon ex
Amazon has restocked the rare Pokémon TCG Prismatic Evolutions Super-Premium Collection featuring 15 booster packs and promo cards.
Lee Health uses federal grant money to expand rural offerings in SWFL counties
A $1.95 million infusion from the $50 billion Rural Health Transformation Program initiated last year will expand the Labelle site to include a walk-in urgent care clinic and a medical lab.
‘We’re healthy’: Mike McCarthy says Steelers have clean bill of health headed into opener
Unlike predecessor Mike Tomlin, judging by his first weekly news conference as Pittsburgh Steelers coach Mike McCarthy does not believe in 10-15 minute-long opening statements buttering up the upcoming opponent or offering a list of injury updates. So when McCarthy stepped to the podium at the UPMC Rooney Sports Complex
Samsung’s Privacy Display and TriFold merge in the Huawei Mate XT2
Huawei has unveiled its new Mate XT2 foldable, offering a tri-fold design that also implements Samsung’s Privacy Display feature from...