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Trump’s D.C. hotel is gone. Mar-a-Lago is now a GOP campaign cash magnet.
Republican campaigns, party committees and PACs have spent nearly $3 million at Trump businesses since his return to office, a Post analysis finds.
Is Eli Stowers playing Monday? Latest Eagles injury update
Eli Stowers is listed as questionable against Dallas after a full practice week as the rookie tight end works back from a quadriceps injury
Office of Mental Health to relax prior approval process for changing services
The changes will streamline the state’s review and approval process for more than a thousand mental health programs.
Inside the Trump Administration's Dismantling of a Health Care Research Office
The Agency for Healthcare Research and Quality has few remaining grant officers and has redirected millions in taxpayer dollars without telling Congress.
Live Nation Entertainment (LYV) Stock Trades Near Fair Value Following Its 121% Run
Live Nation Entertainment has rewarded long term holders, and the stock now trades around US$173.44, which puts its cash generation in sharp focus. With that kind of share price level, the question is whether the current market value can be backed up by the cash flows the business is expected to produce. Over the past 3 years the stock has returned 120.7%, so a lot of future cash flow strength is already being reflected in the price. The company leans heavily on converting concert promotion...
Eric Bauza, who voiced Bugs Bunny and Daffy Duck, dead at 46
Eric Bauza, the actor who voiced “Looney Tunes” characters Bugs Bunny and Daffy Duck, has died “suddenly” at 46. The Canadian-born star died at a home in Los Angeles County on Sunday –...
Is Saquon Barkley playing Monday? Latest Eagles injury update
Saquon Barkley is listed as questionable against Dallas after returning to full practice Saturday. Here’s the latest on his hamstring injury
Mental health event aims to support those who serve and protect
“Resilience: From Service to Strength” is an Oct. 27 Rockledge event focused on mental health for veterans, military and first responders.
This Offseason Will Hold Serious Considerations for These Three Yankees
It’s been weeks now since the 2026 New York Yankees season officially ended. This hasn’t stopped analysts from digging deep into what the future holds for the club. This offseason will involve some deep considerations about the structure of this club. Now more than ever, the Yankees and their ownership and front office want to spend …
Micro1 invests $1B to license data for AI model development
Micro1 is pledging $1 billion to gobble up more companies' internal data for licensing to AI model developers, part of a new wave for the tech.
Apple Music unveils logo that was physically “made by sound”
Apple has revealed the first rebrand for its Apple Music service, which was made in collaboration with musician Fred Again by passing sound waves through a pool of oil.
Many Medicare Patients Could Lose Access to Remote Monitoring Devices
A proposed federal rule could dramatically reduce access to remote patient monitoring programs for people on Medicare. The services aim to keep patients out of the hospital by giving them devices to monitor their health at home, but critics say there isn’t enough oversight.
Thwaites is a runaway climate disaster. New studies show how.
Melt from the "Doomsday Glacier" could drown coastlines around the world. And the outlook is getting even worse.
Pa., N.J. and Del. to kick off 2027 ACA health insurance open enrollment on Nov. 1 as health costs rise: What you should know
ACA customers may face higher premium prices for coverage next year, but insurance experts say most people still qualify for financial assistance.
Patrick Mahomes Puts Chiefs on Notice After Career-Worst Performance
Kansas City Chiefs quarterback Patrick Mahomes shared a brutally honest take after his team lost to the Seattle Seahawks. The post Patrick Mahomes Puts Chiefs on Notice After Career-Worst Performance appeared first on HEAVY.
Ecumenical Patriarch: Church and Medical Science are "partners" in serving life
Ecumenical Patriarch Bartholomew emphasized the importance of cooperation between the Church and medical science during his address at the Church of St. Theodore Tiron in Rome on Sunday, October 25, 2026, paying tribute to healthcare professionals for their service during the COVID-19 pandemic. The Ecumenical Patriarch presided over the Divine…
IRGC Spokesman Mocks CENTCOM Chief over Hormuz Flight
TEHRAN (Tasnim) – IRGC Spokesperson Brigadier General Hossein Mohebbi urged CENTCOM Commander Brad Cooper to face reality after his flight over the Strait of Hormuz, using the latest oil price to challenge Washington’s claims that the strategic waterway remains open.
Banc of Cal Expands to Private Banking
Los Angeles is a hotbed of established and budding personal wealth, and Brentwood-based Banc of California has thrown its hat into the ring to service
‘Been a Problem for a Very, Very Long Time’ — Revisiting the Time Fox’s Pam Oliver Revealed the Health Battle That Impacts Her Sideline Reporting
NFL sideline reporter Pam Oliver has been a fixture in the business for more than 30 years, covering the league for Fox. At 65, she’s also one of the most experienced voices on the sidelines, most recently covering the San Francisco 49ers’ Week 7 matchup against the Atlanta Falcons.
Form 4 AMC Entertainment Holdings Inc: Carla C. Chavarria (SVP CHIEF HR OFFICER) For: 24 September
Form 4 AMC Entertainment Holdings Inc: Carla C. Chavarria (SVP CHIEF HR OFFICER) For: 24 September
Getting health insurance from your job will be extra pricey for 2027
Workers might start feeling faint when they sign up for work-based health coverage for 2027. Premiums are expected to skyrocket for the fourth year in a ...
Pumpkin spice skin care
When it comes to achieving healthy, vibrant skin, what you eat is just as important as the skincare products you apply.
Sleep in total darkness to maintain heart health, researchers say
WASHINGTON — Many a pop song has nudged us to turn the lights down low, but for cardiovascular health, the better choice is to keep them off entirely it seems,
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
E-Z Health helps seniors find relief with dedicated healthcare phone guides
Closing the technology gap, a Medicare-covered program is helping seniors find local resources and save money on essential services. FOX 10's Annalisa Pardo reports.
Eric Bauza, the voice of Bugs Bunny and many other Looney Tunes characters, dies suddenly, family says
Voice actor Eric Bauza, who succeeded Mel Blanc in voicing lovable Looney Tunes characters like Bugs Bunny, Daffy Duck and Porky Pig, had died, his family announced Sunday night. The family issued …
What to Stream: ‘Minions & Monsters,’ Matthew Perry, Daddy Yankee and ‘The Gilded Age’
A docuseries about Matthew Perry and the latest “Minions” movie are some of the new television, films, music and games headed to a device near you. Also among the streaming offerings worth your time this week, as selected by The Associated Press’ entertainment journalists: Daddy Yankee's new album, the fourth season of “The Gilded Age”
Everything Evanston: Fall flavors ramp up spirit, business in Evanston coffee shops
Autumn in Evanston brings seasonal menus and seasonal rushes as coffee shops fill with fall customers. SAMI HELLER: With the weather beginning to fall below 60 degrees, it’s time to ‘fall’ into the season of spooky movies, light sweaters and pumpkin spice. The Daily went into Evanston to see what the season of color-changing foliage...
West Greene Insurance & Tax Service joins GCP
Click here to view this article from greenevillesun.com.
Community members speak out during tense mental health advisory board meeting
Community members impacted by the withdrawal of Kings View services shared concerns during a mental health advisory board meeting last week, saying the closure of a local mental health center had left gaps in care. Board members also navigated a number of other tense moments during the meeting.
Political expert explains what Vice President JD Vance’s upcoming visit means for Kansas
Vice President JD Vance is hosting a rally in Topeka Monday.
How to talk politics with family: Minnesota debate coach shares tips
A University of Minnesota debate coach is sharing advice on navigating political disagreements ahead of Election Day. He explains winning the argument isn't necessarily the goal of a political debate.
How to talk politics with family: Minnesota debate coach shares tips
A University of Minnesota debate coach is sharing advice on navigating political disagreements ahead of Election Day. He explains winning the argument isn't necessarily the goal of a political debate.
76ers veteran briefly raises alarm with injury scare vs. Pistons
The injury hits kept coming around the NBA on Sunday evening , but the Philadelphia 76ers seemingly avoided catastrophe with veteran guard Kentavious Caldwell-Pope. The veteran guard exited the game briefly , as per Adam Aaronson of The Philly Voice, with an apparent injury. While was initially tended to by team staff and accompanied back to the […] The post 76ers veteran briefly raises alarm with injury scare vs. Pistons appeared first on ClutchPoints.
Adventist Health provides hundreds of people with free health and food services
Adventist Health held its second annual free health clinic at the Templeton Hills Seventh-day Adventist Church.
Shares fall in Asia after a decline on Wall Street, and oil prices fall more than 1%
Shares are mostly lower in Asia after a retreat on Wall Street, while oil prices have fallen more than 1%.
Nu Holdings (NU) Faces Political And Leadership Questions, Does It Look Fairly Valued?
Election shock and leadership change put Nu Holdings in focus Nu Holdings (NYSE:NU) is under fresh scrutiny after a Brazilian election result sparked a double digit overnight drop in the stock, just as the fintech disclosed a pending chief technology officer departure. Over the past month, Nu Holdings has seen an 11.55% share price return and a 4.12% gain over seven days, even though the year to date share price return is down 10.93% and the one year total shareholder return has declined...
A Healthy Balance Between Rigor and Mental Health
Many students of Irvington High School typically start their own nonprofits, strive to have 4.0 GPAs and more extracurriculars than can be counted on the fingers. This is typically seen as the “key” to accomplishing an acceptance to a prestigious university, creating a rigorous and competitive environment where students tend to prioritize academic excellence over...
Stray gunfire hits business after early-morning shooting in the Tower District
A business in the Tower District was hit by stray gunfire on Sunday.Fresno Police officers responded to a reported shooting in the area of Fulton and Dennett a
‘You Can See Everything’ becomes highest-grossing documentary at U.S. box office in 15 years
Nathan Fielder has broken the box office in just 2 weeks, as ‘You Can See Everything’ becomes the highest-grossing documentary in the U.S. in 15 years, while ‘Clayface’ opens with a solid start and ‘Wildwood’ bombs.
‘Plans to die in office': Bay Area congressman's ex-aides protest challenger's ads
Seven former staffers of Rep. Mike Thompson demand that challenger Eric Jones' campaign remove a commercial targeting the North Bay legislator.
TWICE's Nayeon to make solo comeback with 'NA-sty' on Nov. 20
Na-yeon of K-pop girl group TWICE will release her new solo project, “NA-sty,” on Nov. 20, marking her first solo comeback in about two years and f...
9th Circuit questions DOJ demand to set aside 20,000 California mail ballots
A panel of federal appellate judges on Sunday questioned the timing, constitutionality and authority of the Justice Department's demand
Fresno police investigate shooting at Airbnb rental in Tower District
The Fresno Police Department is investigating a shooting that occurred early Sunday morning in a Tower District neighborhood.
Johnson County Focus on Youth Fund promotes access to children’s mental health resources
This is an installment of a series exploring youth mental health. The Daily Iowan has received a grant and is partnering with the Solutions Journalism Network to explore the topic. The Johnson County Focus on Youth Fund has been promoting access to children’s mental health resources by providing funding for families who can’t afford services....
Scientists discover Arctic sea ice loss could be far worse than predicted
Arctic winter sea ice could disappear much faster than scientists previously expected, according to new research using climate clues from 6,000 years ago. By comparing ancient ocean sediments with modern climate models, researchers found that future winter ice coverage may be roughly one million square kilometers smaller than earlier predictions suggested.
Tiny magnetic vortices could help computers work more like your brain
Scientists have filmed tiny magnetic vortices called skyrmions melting out of an organized lattice for the first time, revealing new ways to manipulate these unusual structures. The breakthrough could help make brain-like computers a reality, potentially enabling dramatically smaller and more energy-efficient technology.
UCLA Library's Data Science Center closed amid consolidation effort
UCLA Library dissolved its data consultation center and stopped offering data analysis services in August. The university consolidated the Data Science Center into UCLA Library’s research services unit as part of a broader effort to restructure the department, a UCLA Library spokesperson said in an emailed statement.
Columbiana County Health District approve first reading of food service fees
LISBON — The proposed food service fees for next year through the Columbiana County Health District appear to be staying the same or decreasing from this year’s fees, with two more readings required for passage. The county health district board held first reading on the proposed fees on Wednesday, along with first reading on environmental […]
Phantom Blade Zero review: dark wuxia martial arts masters with an apprentice's execution
S-Game's Unreal Engine 5 'kungfupunk' debut can't help but get tangled in frustrating design choices.
9th Circuit panel questions basis for feds' request to block 20,000 California ballots
Two judges questioned the Justice Department's lawyer about how the Trump administration's position squared with the law.
Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega
Kyle Larson took a thrilling win in a wild last-lap rally that led to a photo-finish with William Byron, his Hendrick Motorsports teammate. Larson, who was eighth heading down the backstretch of the final lap, had everything go his way ahead of him, as he sliced and diced his way back to the front. Ricky […] The post Race Results: 2026 NASCAR Cup Series YellaWood 500 at Talladega appeared first on TobyChristie.com.
Xbox console users will receive 50 games from October 26 to 31.
From October 26th to 31st, the Xbox ecosystem and Xbox PC service will receive a major expansion of their catalog, including the release of 50 new games for...
Judges skeptical of Trump administration effort for force California to set aside mail ballots
A three-judge US Circuit Court of Appeals panel expressed significant skepticism Sunday over the Justice Department’s desire to inject itself into California’s midterm vote-counting process by forcing election officials to set aside the votes of suspected noncitizens who have been issued mail ballots.
12 Fun USB-C Gadgets For Your Home Office Desk
Some fun USB-C desk gadgets include the Dockcase Explorer Smart USB-C Hub, Raspberry Pi 500, Creative Pebble SE, Kodak Charmera, and the Divoom Ditoo Pro.
ATM stolen from business in Brighton Park, Chicago police say
Chicago police are looking for the people who stole an ATM from a convenience store Sunday morning on the city's Southwest Side.
Democrat Coumba Kebe wants to keep the politics out of the treasurer’s office
Political newcomer Coumba Kebe is the Democratic nominee for Indiana state treasurer. Kebe wants to keep the politics out of the office and build back trust with people.
Bob on Business: For Fort Worth’s office market, the summer was hot
Also, aviation acquisition and Grapevine company plans big expansion.
Walnut Ridge business starts coat drive for community
The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.
After testing all major mobile browsers, this one finally earned my default spot
Looking beyond Chrome paid off with the best browser experience
Cooper Health launches new mobile addiction and recovery program
The program will focus on high-need areas in the city and respond elsewhere when called, helping to connect people to addiction support services. | KYW Newsradio
Health West Chubbuck expands hours, adds X-ray services and two new providers
CHUBBUCK — Health West has announced that it has expanded the services offered at Health West Chubbuck and that it has added two new providers to its staff as well
How Republican anti-Muslim politics gets built into US cities
Republican anti-Muslim rhetoric can turn religious prejudice into zoning barriers, making equal treatment for all citizens a test of democracy
Brad Pitt's Underrated Sci-Fi Astronaut Movie Deserved Better At The Box Office
You likely missed this critically acclaimed Brad Pitt sci-fi thriller when it was in theaters, but it's a film that warrants a watch.
6 Essential Gadgets For Learning To Play Guitar
We've picked out some of the best gadgets to support the process of learning to play the guitar, including for timing, ear training, and song practice.
Yankees Social Media Spotlight: The MA kids head to MSG
Cam Schlittler and Ben Rice head to Madison Square Garden to watch the Knicks raise a banner.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
TCU to offer lifestyle medicine certification for doctor of occupational therapy students
Lifestyle medicine focuses on helping patients change their lifestyles in order to prevent, treat and reverse chronic disease.
Asher Grunis steps down from leading Submarine Affair commission due to health concerns
Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.
Santa Ynez Tribal Health Clinic to Salute Veterans with Free Dental Services at Annual 'Veterans Smile Day' Event
Credit: Courtesy SANTA YNEZ, CA – October 21, 2026 – The Santa Ynez Tribal Health Clinic (SYTHC) will salute veterans with free dental services at its
Elizabeth Holmes film puts up a fight against 'Clayface' at box office
A movie set in the world of Batman and a three-hour documentary about Elizabeth Holmes went head-to-head at the box office this weekend, and it turned out to be a closer contest than expected.
Elizabeth Holmes film puts up a fight against 'Clayface' at box office
A movie set in the world of Batman and a three-hour documentary about Elizabeth Holmes went head-to-head at the box office this weekend, and it turned out to be a closer contest than expected.
Trump’s Election Attacks Enter New Pre-emptive Phase
A lawsuit by the Justice Department challenging a potential narrow loss by the GOP Senate incumbent in Alaska reflects a new tactic by the president to try to shape the election results.
Trump on high gas prices: 'We're making a freaking fortune"
Americans, meanwhile, are paying record prices at the pump, according to AAA.
Blanche defends DOJ lawsuit blocking Alaska Senate results if Republican loses
Attorney General Todd Blanche defended the Justice Department's suit over Alaska's Senate race in an interview on CNN.
Unpatched Tailscale SSH Flaws Could Let a Hacked Device Reach Root on Other Servers
Unpatched Tailscale SSH flaws could let attackers gain root on permitted servers from a compromised device when port forwarding is enabled.
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
China Star Entertainment (SEHK:326) Stock Looks Richly Priced As Its 8.6x Run Continues
China Star Entertainment has logged very strong multi year share gains, so the key issue now is whether the current price can be supported by the value of assets on its balance sheet. For anyone looking at the stock today, the immediate question is how that share price lines up against its book value. Over the past 3 years the stock has returned about 8.6x. This puts a lot of weight on whether the underlying equity in the business justifies this kind of move when you compare it with the...
Senate rivals seek support from Alaska Native voters
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election
Business People: Evereve names industry vet Sarah Clary to advise on creative
RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…
Police: Lancaster County health care worker assaulted
Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department
BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
3 comments | Progressive Democrats are closely watching four Senate...
Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.
RJW Logistics to open second Northwest Arkansas office
Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily
Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
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