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Jenna Ortega ‘almost fell on’ her face after shooting ‘Iron Man 3’ film debut (exclusive)
Jenna Ortega recalls ‘limping’ home and nearly falling on her face after shooting her film debut in ‘Iron Man 3.’
Kenny Gainwell productive in Week 7
Buccaneers RB Kenny Gainwell played well with bigger workload in Week 7
Garrett Wilson has quiet outing in Week 7
Jets WR Garrett Wilson caught two of his three targets in Week 7 for 26 yards
Luka Doncic explodes for 52 as Lakers beat Jazz
Luka Doncic explodes for 52 as Lakers beat Jazz
Wizards rule out AJ Dybantsa for fourth-straight match
The NBA world will have to wait another night to see AJ Dybantsa's NBA debut.
Marlins Could Adjust Their Attitude Toward Free Agency
The Fish can finance some free agent deals in 2026 with a few interesting names
Knicks' Mike Brown outlines initial plans for former Lakers guard
The Knicks' head coach has made it clear what the team will do with Dalton Knecht.
The Dominant Buccaneers' Offensive Line Everyone Expected Finally Showed Up
The Bucs dominated the Carolina Panthers on Sunday, and the offensive line played its best game of the season.
Kyle Larson’s Championship Moment Comes at Talladega
Conquering his drafting-track demons, Larson surged from mid-pack chaos to secure a historic Hendrick 1-2 finish, building a massive points cushion that places the title within reach
Iowa family finds strength beyond the gym after cancer diagnosis
URBANDALE, Iowa (KCCI) -- Azariah Townsend can barely reach the pull-up bar in his family’s home gym in Urbandale, but he already knows strength is not measured by height.
Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury
The Minnesota Vikings saw running back Aaron Jones Sr. go down with a leg injury late in their Week 7 game against the Indianapolis Colts. The post Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury appeared first on HEAVY.
Xbox console users will receive 50 games from October 26 to 31.
From October 26th to 31st, the Xbox ecosystem and Xbox PC service will receive a major expansion of their catalog, including the release of 50 new games for...
Isaiah Likely disappoints in Week 7 vs. Texans
New York Giants tight end Isaiah Likely limited to two receptions for 12 yards on four targets in Week 7
"I Didn't Seek Help": Terry Bradshaw Reveals Mental Health Struggle; Credits Wife for Pulling Him Through the Darkest Moments
For decades, 4x Super Bowl Champion Terry Bradshaw was hailed for his chirpy, fun-loving personality, but only a few knew the battle he hid under his jokes. Bradshaw struggled to understand that battle for a long period, dealing with darkness that kept returning even when his life was supposedly going well.
Sunday Sports: Section 3 football matchups announced and more
Here’s a recap of your North Country sports this Sunday.
Serbia’s Vucic concedes defeat in seismic political shift
The long-serving strongman leader of Serbia, Aleksandar Vucic, has conceded defeat in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government
A new state on the way? More Illinois counties could vote to leave Chicago behind
More than 30 counties have already approved the non-binding measure to leave Illinois
Walnut Ridge business starts coat drive for community
The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.
Texas Tech Takes 9-Spot Coaches Poll Hit After Cincinnati Meltdown
Texas Tech falls nine spots to No. 14 in the US LBM Coaches Poll after losing at Cincinnati, putting Joey McGuire and the Red Raiders under pressure to rebound.
Orlando is leaning towards starting Jase Richardson in …
Orlando is leaning towards starting Jase Richardson in …
Packers defensive tackle Devonte Wyatt questionable to return after injury
Green Bay Packers defensive tackle Devonte Wyatt questionable to return after injury vs. Detroit Lions.
Nico Collins disappoints in Week 7 vs. Giants
Houston Texans wide receiver Nico Collins posted two receptions for six yards on five targets in Week 7
Peoria business leader accused of DUI in deadly UTV crash
A business executive well known in the local sport community has been arrested on drunk driving accusations for a crash that killed a woman late Saturday night in rural Peoria County.
Bethenny Frankel reacts to Bravo ‘b----‘ Andy Cohen’s shady comments about her TikTok
Bethenny Frankel didn’t hesitate to clap back at ‘bitter’ Bravo boss Andy Cohen for his shady comment about her TikTok page.
Aleksandar Vucic: Serbia's veteran ruler felled by student-led movement
The dominant force in Serbian politics for over 14 years, Aleksandar Vucic, who conceded defeat in a snap parliamentary poll on Sunday, rose from the wreckage of strongman Slobodan Milosevic's cabinet...
C.J. Stroud tosses two TDs in Week 7
Houston Texans quarterback C.J. Stroud completed 17 of 28 passes for 153 yards, two touchdowns and no interceptions in Week 7
Jalen Coker not a big factor in Week 7
Panthers WR Jalen Coker caught only one of four targets in Week 7 and posted only nine yards
🎥 Kylian Mbappé's lucky goal against FC Barcelona
Kylian Mbappé opened the scoring against FC Barcelona this Saturday, October 25.A truly unexpected goal.With both teams looking sluggish from the start, it took until the 42nd minute for the deadlock...
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam
Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.
Justin Jefferson limited to 44 yards in Week 7
Minnesota Vikings wide receiver Justin Jefferson had four receptions for a team-high 44 yards on seven targets in Week 7
Mobile County Health Department updates sentinel chicken test
It concerned testing for St. Louis encephalitis
Cleveland Browns rookie WR hits historic mark against Titans
KC Concepcion’s 129 receiving yards places him in the Top 10 for a single game by a rookie in franchise history.
Kyler Murray throws for 150 yards, TD in Week 7
Minnesota Vikings quarterback Kyler Murray completed 14 of 24 passes for 150 yards, one touchdown and no interceptions in Week 7
Liverpool working towards deal for star; could reach €90m
Liverpool are reportedly in the mix for a very in-demand France star. They’re working towards a deal and it’s one that could cost €90m.Liverpool are weighing up their transfer targets for the up...
When will Myles Garrett return to the Rams?
Here's the latest on Myles Garrett as he continues recovering from early-season knee surgery.
Cavs vs. Timberwolves: How to watch, odds, and injury report
The Cavs will welcome the surging Timberwolves to town.
NH candidates for governor, U.S. Senate, Congress clash over...
At a Manchester forum, New Hampshire candidates clashed over housing, energy, healthcare and other costs as affordability emerged as voters’ central concern. ...
Michigan basketball gets reality check in exhibition loss vs Houston
Michigan writer Tony Garcia offers three observations from the Wolverines' 83-66 loss to Houston in its final exhibition.
Two Georgia Bulldogs ranked among college football's top-25 players
Two Georgia Bulldogs earned top-15 spots on ESPN's midseason top 25 college football player rankings.
Cardinals-Broncos Week 7 discussion thread
Talk about the Cardinals games with your friends at Revenge of the Birds.
When will Jeremiyah Love return to the Cardinals?
Here's the latest on Jeremiyah Love's status for the rebuilding Cardinals.
Why is the U.S. accusing Canada of election interference?
the U.S. Embassy accused Canadian officials of meeting with Democratic lawmakers, urging the use of retaliatory levies to hit Republican states, and running anti-tariff political advertising.
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again
Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.
Sky Sports share rumours of unhappy Leeds United star live on air vs Sunderland
Daniel Farke looking unimpressed as Leeds United take on Sunderland at Stadium of Light on 25 October
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Halloween evolved as a Frankenstein of cultural celebrations
The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.
Cardinals Week 7 inactives
Cardinals announce seven inactives ahead of Week 7 game
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Nigeria widens hunt for possible Ebola cases
Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...
Ramaswamy built his political career in NH. It's faltering in Ohio.
Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?
Detectives seek information about business conducted with Piedmont Memorial Park Cemetery
Detectives are seeking information from anyone who has conducted business involving the cemetery since January 2019.
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina
Penalties, brain blips and a hangover conspire to doom Volunteers.
Projections for Cleveland Guardians’ Arbitration Eligible Players
The Cleveland Guardians have several key players arbitration-eligible this offseason.
Lakers at Jazz: What to watch in first road game
Walker Kessler needed only two games to show how much he could change the Los Angeles Lakers' frontcourt.
‘Clayface’ Ties ‘Obsession’ For A Rotten Tomatoes Audience Score Record
'Clayface' has a Rotten Tomatoes audience score that matches Obsession's a wild achievement for the comic book film.
What Will It Take for Rockies to Make World Series?
It's been since 2007 for the Colorado Rockies to be a part of the World Series. Is there any hope for a return to the Fall Classic?
Lady Gaga dancer reveals why he thinks she’ll succeed at motherhood
Lady Gaga’s backup dancer, who slid off stage mid-performance during last year’s Mayhem Ball world tour, is opening up about why he believes the singer will succeed at motherhood.
Senate rivals seek support from Alaska Native voters
The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election
What are you reading this week?
Our reading list never stops growing, but this week we're digging into buzzy literary thriller Fruit Fly and a sweet paranormal romance.
Broncos Place Linebacker, Running Back On Injured Reserve
The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.
Saints Lose Defensive Battle in Paris Against Steelers
A very winnable game that a better team would have won.
Warriors honor Bay Area sports reporter Michael Wagaman
After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…
Browns injury update: Is Denzel Ward playing against the Titans?
The Browns will enjoy the presence of their top cornerback in Week 7.
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie
Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.
Week 7 inactives for Ravens
Baltimore declares five players inactive versus Cincinnati
Is having urine the color of Mountain Dew normal?
A Trump administration doctor says neon yellow urine is normal because of diets consisting entirely of meat and fermented foods. Here’s what experts say
Baltimore Ravens vs. Cleveland Bengals Week 6 game discussion
Join the discussion about the Ravens’ Week 7 matchup with the Bengals!
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes
Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.
Nonprofit organizes ‘silkies’ hike to support military members’ mental health
Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.
California Politics 360 full episode | Clash over voter rolls heads to court
On Tuesday, one week before the election, a federal judge will determine the next steps.
Cam Skattebo Update: Will Giants Star RB Play Against Texans?
New York Giants share news on RB Cam Skattebo after benching in Week 6. The post Cam Skattebo Update: Will Giants Star RB Play Against Texans? appeared first on HEAVY.
Robinson, Baker have tough talk about the offense
Robinson, Baker have tough talk about the offense
Micron Just Revealed a New Business Strategy. That Change Makes It a Screaming Buy.
Micron is changing more toward contracts, rather than letting the open market dictate pricing.
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.
Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.
10 Thoughts From Watching Others Sweat It Out
Back during the very lean years of the Ray Goff era in Athens, a certain revered columnist for the Macon Telegraph joked in a weekly prediction column that Georgia would lose to “Open” during its upcoming bye week. Thankfully, those years have passed by, and the outlook for Georgia during open weeks for what is […]
NFL Trade Deadline Could Dramatically Change The AFC South Landscape
With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.
Arch Manning has another viral moment with ESPN's Holly Rowe
The Texas quarterback was happy to see Rowe on the sidelines.
Preview
The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...
Silicon Valley software engineer pay ranked against other US cities
Bay Area software engineers retain a 53% pay premium after adjusting for local prices, Levels.fyi found. Taxes aren't included.
31 'Brooklyn Nine-Nine' Memes That Would Win a Halloween Heist and Become the Ultimate Detective/Genius
These memes are noice!
Maliek Collins agrees to terms on contract extension
Maliek Collins to remain in Cleveland for two additional years
Investment driving growth at NWS Crane
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Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Explore Health, Oregon’s new health insurance marketplace, is ready for business
This fall, Oregonians who buy health insurance directly instead of getting it through their employer will need to use a new website, the Explore Health marketplace.
Crystal Palace v Chelsea
Follow live text commentary, score updates and match stats from Crystal Palace vs Chelsea in the Women's Super League
Clemson HC Dabo Swinney Waving White Flag on Season
Following a humbling loss to Virginia Tech, Dabo Swinney is recalibrating expectations as the Tigers abandon playoff dreams and fight to salvage a disappointing, sub-par season.
NFL Week 7 expert picks, score predictions: Packers at Lions
Green Bay Packers vs. Detroit Lions NFL Week 7 expert picks from the Pride of Detroit staff.