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The Supreme Court seems alarmingly willing to trash thousands of ballots
At least four justices appear to be on board with a frivolous lawsuit attacking voting by mail.
Uplifting and Not Ceding Ground on Health Equity Practice Is Critical to Strengthening Public Health and the Health of the Nation
Public health science gains in the last quarter century in the United States have been formidable due to a focus on structural and social determinants of health, thereby enhancing understanding of the role of inequitable policies in shaping health inequities and inequitable access to ameliorative resources.
SCOTUS conservatives signal readiness to curb late-arriving mail ballots
Conservative Supreme Court justices appeared skeptical during oral arguments of allowing states to continue counting late-arriving mail-in ballots. A decision is expected in June.
Expanded NICU offers families privacy, innovation
The NICU at Temple Health's new Women and Families Hospital offers twice the space and many more services than its predecessor.
Intel Core Ultra 7 270K Plus Review - Intel's Fastest Gaming CPU
The Intel Core Ultra 7 270K Plus is a game-changer, featuring more cores and larger cache than the 265K, while cutting the launch price to just $300. In gaming, it outperformed all non-X3D Ryzen CPUs, and application performance is impressive as well, matching the much pricier Ryzen 9 9950X.
Intel Core Ultra 5 250K Plus Review - Disrupting AMD's Entry-Level
Intel is breathing new life into its Arrow Lake lineup with the Core Ultra 5 250K Plus. Priced at an attractive $200, this little powerhouse outperforms most AMD CPUs in applications and delivers competitive gaming performance, too. It's a strong contender for budget-friendly builds, and overclocking potential is good, too.
Thousands in taxpayer funds spent on horse, hair and makeup expenses for Kristi Noem’s Mount Rushmore ad
Tens of thousands of taxpayer dollars were spent on expenses for hair and makeup artists and a horse for the advertisement showcasing outgoing Department of Homeland Security Secretary Kristi Noem in front of Mount Rushmore, according to invoices seen by CNN.
Voice of America Journalists Sue, Saying Trump Officials Interfered in Coverage
The journalists said in the complaint that the administration was trying to force them to be a “mouthpiece” and that one official demanded “loyalty” if reporters wanted to “keep their jobs.”
iPhone Air Said to Be Roughly Twice as Popular as iPhone 16 Plus
While it certainly has its critics, the iPhone Air appears to have validated Apple's decision to retire the iPhone Plus, if new results from an independent analysis are anything to go by. Crowdsourced Speedtest data published by Ookla suggests the iPhone Air captured 6.8 percent of iPhone 17 generation samples in the U.S. during the fourth quarter of 2025, up from the 2.9 percent share the iPhone 16 Plus managed in the same launch window a year earlier.
Southcoast Community’s Choice Awards business spotlight: Perfect Smiles Dentistry
Nominations for the SouthCoast Community's Choice Awards are rolling in! Don't miss your chance to recognize your favorite local businesses.
Caesars Entertainment (CZR) Valuation Check After Recent Share Price Recovery
Caesars Entertainment stock overview Caesars Entertainment (CZR) has been drawing attention after recent share price moves, including a gain over the past month. This has prompted investors to reassess how its current valuation lines up with recent financial results. See our latest analysis for Caesars Entertainment. Recent trading has been choppy, with a 26.05% 1 month share price return contrasting with a 4.87% decline in 1 year total shareholder return. This signals momentum building in...
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return
A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.
Exit polls suggest Italy's Meloni has narrowly lost justice referendum vote
Exit polls on Monday suggested Italian Prime Minister Giorgia Meloni had narrowly lost a referendum on her flagship reform of the judicial system, dealing a potential blow to the ruling coalition ahead of next year's general election.
When Vermont’s treatment landscape shifts, community providers step up
As Vermont’s substance use treatment landscape shifts, community providers are stepping up to maintain access to care. In Washington County, strong partnerships ensure rapid connection to treatment, recovery services, and coordinated support.
WSU launches bilingual video series to help beekeepers improve colony health
Researchers with WSU's Honey Bee and Pollinators Program have produced a new video series giving novice keepers a strong introduction to best practices and the science of apiculture, in both Spanish and English.
Marquette Law School adds Aaron Hernandez to National Sports Law Institute leadership
Aaron Hernandez, currently at Arizona State University’s Sandra Day O’Connor College of Law, will be joining the faculty at Marquette University Law School as associate professor of practice and director of the National Sports Law Institute. Marquette is led in the area of sports law by Matt Mitten, professor of law, and Paul Anderson, associate…
Microsoft Exchange Online service change causes email access issues
Microsoft is working to address an ongoing service issue that has intermittently prevented some users from accessing their cloud-based Exchange Online mailboxes via Outlook mobile and Mac desktop clients since Thursday.
Data Is at the Heart of What Public Health Does
Data is key to protecting the health and safety of a community, from identifying and tracking disease outbreaks to ensuring that water is safe to drink. Data is also vital to understanding where resources are most needed. This value is especially apparent to the officials charged with protecting public health, such as Dr. Janet Berreman, Kauai’s (Kauaʻi’s)* district health officer.
Trump whistleblower Alex Vindman: ‘Sitting on the sidelines was not an option’
Democratic Senate hopeful says experience of being key witness in Trump’s first impeachment makes him right choice for Florida
What’s the science behind ice thickness and when it’s safe to drive on a lake?
A Canadian ice researcher came up with a formula in 1971 for ice roads. It’s still the foundation for safety guidelines.
Report: iPhone Air is about twice as popular compared to the Plus model it replaced
According to cellular network data from Ookla, the iPhone Air is about twice as popular compared to the iPhone 16...
Sound Advice: A quality soundbar to take your home entertainment system to the next level
Q. You mentioned that the TCL QM9K television sounded so good that an external soundbar was not necessary. I find that most televisions sound awful,...
A Look At PENN Entertainment (PENN) Valuation As Expansion Projects And New Financing Move Ahead
Expansion plans and fresh financing reshape the PENN Entertainment story PENN Entertainment (PENN) has put expansion and balance sheet moves front and center, with new casino and hotel projects in Aurora and Columbus alongside a fresh US$600 million senior notes offering. See our latest analysis for PENN Entertainment. Despite the new projects and financing, PENN’s 1 year total shareholder return of 21.21% and 5 year total shareholder return of 86.08% sit well behind peers. A recent 4.99% 1...
The New Party Politics of Abortion
Some Republicans remain consistently pro-life. But under Trump’s lead, the GOP has become an anti-Roe yet pro-choice coalition.
Samsung adds native AirDrop support to Galaxy S26 devices
Share files with Apple-using friends
Fertilizer prices bring more pain for American farmers amid war in Iran
The war in Iran is pushing up prices for already-strained farmers, with higher costs for fertilizer and energy on top of last year’s tariffs. And the increasing pressure on American agriculture could lead to even bigger price tags at the grocery store.
Scientists See Converging Evidence of Antarctic Ice Retreat
A sediment core spanning millions of years and new modeling studies point to significant ice retreat under temperatures similar to today.
Personnel note: Shutts & Bowen adds veteran trial lawyer Bernie Pastor to Miami office
Shutts & Bowen is expanding its Business Litigation Practice Group with the addition of Bernard “Bernie” Pastor as a Partner in its Miami office.
Subaru’s New Sports Vehicle Planning Office Teases Lifted BRZ
The turbocharged rally car has all-wheel drive and a raised suspension.
Four Jewish ambulances set on fire in London in what health secretary calls 'sickening' attack
The attack on the Jewish Community Ambulance service in north London is being treated as an "antisemitic hate crime", the Metropolitan Police says.
St. Louis Blues Weekly Prospect Report (March 22)
Jiricek has big scoring week; McIsaac announces future plans; Ralph, Michigan State head to NCAA Tournament with Mayich, Clarkson University eliminated; Peterson scored pair, including a SH beauty for Springfield
Costco Expands Member Offerings With Fertility Care And In Store Events
Costco Wholesale has partnered with Sesame and IVI RMA North America to offer U.S. members access to advanced fertility care with exclusive pricing and coordinated services. The retailer is also rolling out a national outdoor cooking roadshow in warehouses, featuring multiple brands and on site experiences for members. These moves extend Costco’s reach further into healthcare services and experiential retail beyond its traditional bulk merchandise model. For investors tracking...
How Obama’s Strategist Discouraged Biden From Running in 2016
In a new set of oral histories, David Plouffe, President Barack Obama’s political adviser, described how he urged Vice President Joseph R. Biden Jr. not to challenge Hillary Clinton for the nomination.
Dean for Basic Science Colin Duckett tapped to serve as Boston University Provost
Duckett, executive vice dean for basic and preclinical science, will begin his tenure as chief academic officer at Boston University starting in July.
Color of Hockey: Williams helping to grow sport on, off ice in Jacksonville
Works for Sabres ECHL affiliate as goalie coach, director of community development
These Michigan U.S. Senate candidates took money from ICE contractors
Anti-ICE messaging is expected to be featured prominently in Michigan's hotly contested U.S. Senate Democratic primary.
Simona Martin: Colorado’s data center boom needs public health guardrails
As AI infrastructure expands across the state, lawmakers face a choice about who bears the costs and risks.
Scientists Trap Light in a Layer 1,000x Thinner Than a Hair
Scientists have found a way to trap light in an extremely thin layer, potentially reshaping how future photonic devices are built.
Commentary: Keep Kentucky judges judging and leave politics to politicians
A provision in House Bill 534 would invite judicial candidates to disclose their political party affiliation and their current and past voter registration, including “communicating political values or viewpoints consistent with his or her party affiliation.”
Iranian Missile Strikes Are Costing Big Oil Billions in Lost Revenue
Damaged energy infrastructure is likely to take years to come back online, but a surge in oil-and-gas prices is helping to offset some of the lost production for now.
5 Laptops With Better Specs Than The MacBook Neo For The Same Price
The MacBook Neo starts at $600, but these five laptops deliver better RAM, storage, and larger screens for the same price or less.
Statue of Christopher Columbus installed on White House grounds
A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.
Joe Kent says he wants Donald Trump to hear MAGA opposition to Iran war
It’s a concerted effort, Kent said, to rally members of the president’s Make America Great Again movement and ensure he hears dissenting voices.
Chelan Co. Sheriff’s Office secures nearly $55k in funding for behavioral health unit
The Chelan County Sheriff’s Office has secured nearly $55,000 in outside grant funding to support and expand its behavioral health crisis response program, allowing the agency to add training, equipment and other resources without using county funds.
IMCOM-E international business advisor helps service members, families with tax relief programs
IMCOM-E international business advisor helps service members, families with tax relief programs
The war in Iran's impact on gas prices in Texas
NBC 5’s Phil Prazan tells us about the continued Texas impacts of the war in Iran as shockwaves are sent through the oil industry.
Locally-based behavioral health group to open first Louisville office
The location will provide individual, couples and family therapy.
'Project Hail Mary' blasts off to record-breaking $80 million, becomes 2026's best premiere
'Project Hail Mary' burned through the outer layer of box office projections this weekend, reaching an astounding $80 million in its domestic premiere and $141 million worldwide.
Samsung Brings AirDrop Support to Quick Share with Galaxy S26 Series
Samsung is introducing AirDrop support to the Galaxy S26 series, making it easier for users to share content between devices using Quick Share. The feature will begin rolling out from March 231, starting in Korea and expanding to more regions including Europe, Hong Kong, Japan, Latin America, North America, Southeast Asia, and Taiwan. AirDrop support […]
Samsung rolling out AirDrop over Quick Share on Galaxy S26, more devices coming
Samsung has officially confirmed plans to start rolling out AirDrop support over Quick Share starting with the Galaxy S26 series...
How the G.O.P. and Democrats Are Talking About the Surge in Gas Prices
Republicans have largely been on defense against Democratic criticism. Here are five arguments advanced by figures in both parties.
Politics, protests and popular culture: The University of Minnesota community responds to ICE impact through memes and music
Outside Coffman Union on March 3, The University of Minnesota’s Students for a Democratic Society protested Immigration and Customs Enforcement’s presence in Minnesota and on campus, despite reports that Operation...
Oil prices rise after Trump issues ultimatum and Iran threatens to close the Strait of Hormuz indefinitely
Oil prices rose Sunday after President Donald Trump threatened to “obliterate” Iran’s power plants if the Strait of Hormuz is not reopened by Monday evening.
Business closed after new Ohio law banning intoxicating hemp products went into effect
Senate Bill 56 grants law enforcement the authority to remove intoxicating THC products from unlicensed retail locations,
‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM, and the year
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales — the second biggest ever for a non-franchise film.
Former acting ICE director under Obama shares concern about ICE airport deployment
Woman seeks help at Aurora business after suffering serious injuries in shooting
A woman collapsed inside an Aurora business while seeking help after she was shot Saturday night. Police are trying to determine what led up to it.
Educational Service Center awarded Teach Computer Science 2.0 Grant
The Educational Service Center of the Western Reserve has been awarded $584,614 through the Ohio Teach Computer Science 2.0 State Grant, a competitive initiative funded by the Ohio Department of Higher Education. As part of an $8 million…
Apple Store Prices for SanDisk SSDs Are Suddenly Astronomical
A 200% price hike is extraordinary.
Federal union says 'untrained' ICE agents shouldn't replace TSA
President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.
Kentucky Gov. Beshear takes jabs at JD Vance in his home state of Ohio
Kentucky Gov. Andy Beshear, speaking in JD Vance’s home state of Ohio on Saturday, tore into the vice president, questioning his Appalachian roots and telling voters they “deserve better.”
Nevada Wins Temporary Ban on Sports Betting on Kalshi
The prediction-market platform must obtain state gambling licenses and prohibit users under 21 to offer such contracts, a state court said.
City of Paducah Finance Department to host informational workshop on Business License Renewals
In case you missed it, the City of Paducah Finance Department will host an informational workshop on Business License Renewals for local business owners at the McCracken County Library tomorrow,
Khloé Kardashian Recalls How Her Divorce from Lamar Odom Made Her ‘Obsessed’ with Leading a Healthy Lifestyle
Khloé Kardashian opened up about her relationship with diet and exercise on the March 18 episode of her podcast, ‘Khloé in Wonder Land.’ She said she became ‘obsessed’ with exercise after examining how her food choices were affecting her quality of life.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Politics Now: March 22, 2026
This week on Politics Now with host John Langeler: Nevada is trying to lessen its reliance on fuel from California. We talk with the vice-chair of the committee tasked with determining how to do th…
United Airlines Just Issued a Playbook for Any Business Staggered by Skyrocketing Costs
In a letter to employees, CEO Scott Kirby delivered a master class on boosting morale as he deals with the impact of surging jet fuel prices.
Mississippi State Health Officer Dr. Daniel Edney, a Vaccine Proponent, Is Under Consideration to Lead the CDC
Dr. Daniel P. Edney, Mississippi’s state health officer and head of the Mississippi State Department of Health, is now under serious consideration to lead the CDC.
US, Iran threaten more energy strikes as gas prices surge. What to know
As the U.S.-Israeli war with Iran enters its fourth week, the economic consequences continue to rattle markets.
Oil prices face new pressure as US and Iran trade threats
Trump said the US would attack Iran's power plants if it didn't reopen the Strait of Hormuz in 48 hours. Iran responded on Sunday with is own threats.
Trump mocks 'discombobulated' Schumer over Democrats' near gaffe on funding ICE
President Donald Trump mocked Chuck Schumer after the Senate minority leader accidentally said "We must fund ICE" on the Senate floor amid the DHS funding shutdown fight.
Home health aides epitomize a key problem in the current job market
About 4 million people were employed as home health and personal care aides in 2024. They earn just $16.78 an hour, despite the need for their services being intense.
Assemblywoman Alexandra Macedo says César Chávez allegations are "just the tip of the iceberg"
California lawmakers this upcoming week are set to move quickly to rename César Chávez Day to Farmworkers Day ahead of the holiday that takes place every year on March 31.
The '80s Car Feature That Would Fit Perfectly In The AI Hellscape Of Today
The '80s car feature that would fit perfectly in the AI hellscape of today is Chrysler's Electronic Voice Alert that gave drivers warnings by speaking to them.
Box Office: ‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales. It's the biggest opening for the studio and the...
Box Office: ‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales.
This CEO took legal advice from ChatGPT to avoid paying $250 million bonus. It backfired
The court stressed that company executives are expected to exercise independent judgment, not outsource good-faith decisions to an AI.
Homan says ‘more conversations need to be had’ to end standoff over ICE, DHS funding
Apple Has Released More Than 10 Products and Accessories This Month
It has been a busy March for Apple, which has unveiled more than 10 products and accessories this month. However, aside from the all-new MacBook Neo and Studio Display XDR, the devices received faster chips or new colors and little else.
Lancaster County public sales: March 22, 2026
Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and
Trump touted bigger tax refunds this year, but Americans will likely spend them on gas
Spiking gas prices in the U.S. are on track to eat up tax refunds this year, leaving most Americans with little extra to spend.
Dynamax Regice Max Monday: Event Guide
Max Monday features a different Pokémon in power spots for the whole day. Regice Max Monday takes place on March 23rd, 2026. This Max Monday is the fourth March Pokémon, and it is the debut of the legendary Ice Pokémon Dynamax Regice! Dynamax Regice is a Tier 5 Max Battle in Pokémon GO. It will cost […]
Get ready to vote in the next Detroit Community Choice Awards
The awards program seeks to shine a light on outstanding businesses in Wayne, Oakland and Macomb counties.
The war on Iran is in its fourth week. Here’s what to know
Three full weeks of the war the US and Israel launched against Iran have shocked the world oil market, pierced a sense of safety in parts of the Middle East, and claimed the lives of US service members and civilians in multiple countries.
‘We can create hype’: H&M’s UK boss on its commitment to the high street
As the chain marks 50th anniversary in Britain, Karen O’Rourke explains what makes it stand out against cut-price rivals
Businesses worried as fuel prices rise
An increase in fuel prices amidst the US-Israel war with Iran is affecting businesses in the UK.
Paxton Aaronson scores twice to propel Rapids to 4-1 victory over Sporting KC
Paxton Aaronson scored a goal in each half, Wayne Frederick's first career goal was the go-ahead score and the Colorado Rapids rolled to a 4-1 victory over Sporting Kansas City on Saturday night. Aaronson gave Colorado (3-2-0) the lead in the 12th minute, but Shapi Suleymanov scored for the first time this season — in the 44th — to pull Sporting KC (1-3-1) even. The tie lasted until the second minute of stoppage time when Frederick scored unassisted for a 2-1 lead at halftime.
Person robbed at gunpoint outside Dracut business
Dracut police say two suspects in black robbed a man at gunpoint, then fled in a silver Ford Explorer, which was later found. No arrests announced.
Deals: Galaxy S26 series gets its first price drop, the Pixel 10 series drops even further
Meanwhile, the 2025 MacBook Airs are getting cheaper too - not quite as cheap as the Neo, but they are an important alternative for those who need more RAM.
Amanda Peet Shares Breast Cancer Diagnosis
Amanda Peet detailed her recent breast cancer diagnosis in a new essay, sharing that her health battle coincided with both of her parents' final months in hospice care.
Health Literacy as a Modifiable Clinical Risk Factor: Operationalizing an Underrecognized Determinant of Outcomes
Health literacy has been considered a social determinant of health and has never been extensively incorporated in the general practice of clinical care. Systematic reviews and cohort studies sho...
Dana Walden unveils leaders of expanded Disney Entertainment
Dana Walden, the incoming President and Chief Creative Officer of The Walt Disney Company, has unveiled the new leadership structure for Disney Entertainment, bringing together the company’s streaming, film, and television businesses along with its games and digital entertainment division.
Austin soul food staple Hoover’s Cooking to close after nearly 30 years
While the Manor Road soul food spot is ending its sit down dining service, it will still book private events through the summer.
Sanford Sports launches in Black Hills region
Sanford Sports is expanding into the Black Hills, bringing its research-backed training programs and services to athletes across the region.
WHO verifies deadly hospital attack in war-torn Sudan
The World Health Organization (WHO) verified on Saturday a hospital attack in war-torn Sudan that killed 64 people.
Politics Unplugged (Full Episode) March 22, 2026
This week on Politics Unplugged, Progressive activist Kai Newkirk explains why he is running to unseat Democratic incumbent Greg Stanton in the congressional race in CD4. Then, consultants Marcus Dell’Artino and Matt Grodsky discuss the fallout from the Cesar Chavez allegations and the political importance of high gas prices.
Hochul running mate visits Long Island businesses struggling amid ICE raids
"Business is very, very bad," said the owner of Dulcemania II Saturday. "People are scared, afraid to come out."
PSN Service Returning on PS5, PS4 as Brief Outage Took Service Offline
Taken offline for roughly two hours
Sony PlayStation Network down: PS5 users report widespread server issues; 'please fix it'
Sony PlayStation Network appeared to be down for thousands on Saturday as many flocked to social media to voice their complaints. | World News
Trump threatens to deploy ICE agents to airports Monday if funding deal isn’t reached
President Donald Trump said Saturday he will deploy Immigration and Customs Enforcement agents to US airports on Monday if an agreement isn’t reached to fund the Department of Homeland Security amid a partial government shutdown.