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Accrington Victoria Hospital site to become health and care hub
Accrington Victoria Hospital closed in 2024 after the building was found to be beyond repair.
Crowded Democratic Race for California Governor Could Open Door for Republicans
By Joseph Ax and Costas Pitas March 24 (Reuters) - By many measures, California is the center of the Democratic Party's political universe. The most populous U.S. state, it is home to both the party's last presidential nominee, Kamala Harris, and possibly its future one, Governor Gavin Newsom. But ...
'Dhurandhar' Powers India's Record $2.18 Billion 2025
'Dhurandhar' headlines a record $2.18 billion film year as India's M&E sector grows 9% to $29.63 billion in 2025, per the annual FICCI-EY report.
'I Don't Use AI Much': Apple Co-Founder Expresses Skepticism AI Can Replace Humans
"I'm disappointed a lot," Steve Wozniak said of AI.
Colorado’s Tamale Act may decide whether home cooks can build a business
An eclectic coalition, including the MAHA call for “food freedom,” gave the law a second chance as backers push for immigrant assistance and entrepreneurship.
CDC dilemma: Nominee may need both MAHA and science chops
As a deadline arrives this week to nominate a Centers for Disease Control and Prevention director, some Republicans are skeptical the administration will find someone who can check all the boxes necessary for confirmation. The candidate will need the “Make America Healthy Again” mindset of Secretary Robert F. Kennedy Jr.’s Health and Human Services Department, […]
No fuel shortage in Britain, says minister, as Reeves prepares to set out economic response to Iran war
Energy minister Michael Shanks reassures drivers ahead of chancellor’s statement to MPs
Special Battleground Report on Food and Health Part II: Messages
This Navigator Research report covers messaging guidance to effectively communicate on food and health-related issues to Americans in the battleground.
Nintendo reportedly adjusting Switch 2 production after weak holiday sales
Sources say lower production volume is expected to continue in April
New Xbox CEO Could Make Game Pass Less Expensive, Report Says
Asha Sharma is reportedly trying to make Xbox "more enticing to a broader range of customers."
Perplexity CEO said AI could spur a small entrepreneurship boom
Aravind Srinivas said AI will lead to job cuts — and create small business opportunities.
The Supreme Court’s conservatives could significantly alter the 2026 election
The Supreme Court on Monday appeared ready to limit mail-in ballots, a move that would reinforce the justices’ pattern of shrinking voter protections and that has, at bottom, favored Republican interests and the Trump administration.
Modernizing Pinnacol is about its members, not politics
By Akasha Absher While we share the passion for protecting Colorado’s workers expressed in a recent op-ed from the perspective of trial attorneys and union representatives, the piece paints a picture of Pinnacol Assurance that is more rooted in 1915 than our 21st-century reality (“Colorado’s workers can’t afford a privatized Pinnacol | OPINION,” March 17). […]
Is the Center Still Alive in Big-City Politics?
Left-leaning mayoral winners are getting a lot of attention, but in a few cities business-friendly moderates are showing strength.
Mobile sports betting may soon be legal across Wisconsin
Online sports betting could soon be legal in Wisconsin through a new bill passed by the state legislature, which awaits signature by Gov. Tony Evers. The bill passed with bipartisan support in the state Senate Wednesday, with 12 Democrats and nine Republicans voting in favor, according to the Milwaukee Journal Sentinel. The bill revises the...
Android Auto is breaking for Pixel and Samsung users, and no one knows why
Users are reporting connection issues associated with a recent update and an Android 16 security feature.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Arizona State hires longtime Saint Mary's head coach Randy Bennett to replace Bobby Hurley
Top Senate Republicans coalesce behind plan to end DHS shutdown
Top Senate Republicans on Capitol Hill believe their party is unified behind a plan to reopen the Department of Homeland Security. Now, they need to sell the plan to Democrats.
Entertainment district ordinance repeal not on city council agenda
Entertainment district ordinance repeal not on city council agenda
Entertainment district ordinance repeal not on council agendas despite Ward 7 councilmember claims
Norman City Council will not see an ordinance repeal related to the Rock Creek Entertainment District during Tuesday’s city council meeting, despite a statement from a council member that it
Milledgeville teen runs car detailing business in school, wins $1,000 in chamber contest
At 19 years old, Kyan Silas has started a successful business and received second place in the youth entrepreneur program, landing him a $1,000 prize.Kyan Sila
Markwayne Mullin confirmed to lead Department of Homeland Security
The Oklahoma Republican faced a glide path to confirmation with the help of two Democratic senators.
Scientists say NAD+ could slow aging and fight Alzheimer’s and Parkinson’s
A global team of leading scientists is zeroing in on a tiny but powerful molecule that could reshape how we age. Known as NAD⁺, it plays a crucial role in keeping our cells energized, repairing DNA, and maintaining overall health—but its levels steadily decline over time, potentially fueling diseases like Alzheimer’s and Parkinson’s. Researchers are now exploring ways to boost NAD⁺ using compounds like NR and NMN, with early studies hinting at improvements in memory, metabolism, and physical function.
Insulin pills may soon replace daily injections
For over a century, scientists have chased the dream of insulin pills, but the digestive system kept destroying the drug before it could work—forcing millions of patients to rely on daily injections. Now, researchers at Kumamoto University have developed a clever workaround using a tiny peptide that helps insulin slip through the intestinal wall.
Aramark Sports + Entertainment’s Culinary Creativity Takes the Field at Eight MLB Stadiums as Umpires Shout “Play Ball!”
As Major League Baseball prepares to welcome fans back for another season of unforgettable moments, Aramark Sports + Entertainment (Aramark; NYSE: ARMK) is stepping up to the plate with a new lineup of culinary innovations, collectible souvenirs, and fan‑driven experiences debuting across eight MLB stadiums nationwide.
Playoff-bound Wild, Lightning out to improve positioning
The Minnesota Wild and Tampa Bay Lightning, two powerhouses preparing for the playoffs in their respective conferences, will complete their two-game season series in Tuesday night's matchup in the Sunshine State.
Businesses prepare for Treefort Music Fest to take over downtown Boise
Trump places replica Christopher Columbus statue near the White House
A statue of Christopher Columbus has been placed on the grounds of the Eisenhower Executive Office Building adjacent to the White House, the latest effort by President Donald Trump's administration to recognize the controversial explorer.
SC sees historical ranking in a 2025 national health ranking
South Carolina came in at 36th in the United Health Foundation's America Health Rankings 2025 annual report, the state’s best ranking since the report started b
Trump puts Republicans in a bind on the DHS shutdown: From the Politics Desk
Plus, the Supreme Court hears a case with big midterm implications.
‘Don’t Make Any Deal’: Trump Tells Republicans to Hold Firm on Shutdown Talks
The president is using the standoff over funding the Department of Homeland Security as leverage to pass a strict voter ID bill. Critics say the bill would place an undue burden on eligible voters.
It’s a Chaotic Moment in America. That’s Not What Republicans Need.
A national mood of unease and anxiety ahead of major elections is rarely good for the party in power.
Democratic and Republican Party officials face internal backlash after primaries
Party officials have received calls to resign amid endorsements and campaign spending in national and state primary elections.
The View: Politicians Disappear From ABC Show After Trump FCC Threat
The ABC panel show hasn't had any political guests on since the FCC announced it was investigating it. That changed today as the network fights the feds ahead of the midterms.
Travis Kelce reportedly re-ups with Chiefs on a 3-year, $54.7 million deal, but there's a catch
Babson and Microsoft Team Up to Help Small Businesses with AI · Babson Thought & Action
Students from The Generator, Babson’s interdisciplinary AI lab, worked with small business owners to give feedback on a Microsoft AI tool.
Fall River's Day of Portugal announces dates, entertainment lineup for 2026
A festival that brings food, faith, and entertainment to the city will be returning once again. Day of Portugal Fall River, which takes place every year at the Gates of the City down near the waterfront on Ponta Delgada Blvd., is back in 2026. One of the more popular events in Fall River which
Trump administration adds State Health Officer Dr. Daniel Edney to short list of nominees for CDC director
State Health Officer Dr. Dan Edney is among the contenders to head the nation’s Centers for Disease Control and Prevention, the Washington Post reported
Mexico's Karim Lopez reportedly declares for the 2026 NBA Draft
Lopez could become the first player of Mexican descent selected in the first round.
Bachelorette suitor from canceled season drove car in Madison Cawthorn crash
A 'Bachelorette' suitor from Taylor Frankie Paul's now-scrapped season was the driver in the 2014 car crash that paralyzed former Republican congressman Madison Cawthorn.
From radio to newsreels to Netflix, Yankees chart course through entertainment history
For more than a century, the Yankees have been more than a baseball team. The sport’s most storied franchise is a pop culture touchstone, a versatile backdrop that serves as both a symbol of excellence and a punchline across television, movies and more. So as the Yankees prepare to break
Cargo Headed to Station, Week Begins with Science Prep and Maintenance
A cargo spacecraft is in orbit catching up to the International Space Station for a docking tomorrow to deliver food and supplies to the Expedition 74 crew. Aboard the orbital lab, the seven residents kicked off the week with science operations prep, routine maintenance, and getting systems ready for a future spacewalk.
Stephanie Laing Signs With Linden Entertainment For Management (EXCLUSIVE)
Director Stephanie Laing has inked with Linden Entertainment for Management. She remains repped by CAA and Myman Greenspan.
Voice of America Journalists Sue, Saying Trump Officials Interfered in Coverage
The journalists said in the complaint that the administration was trying to force them to be a “mouthpiece” and that one official demanded “loyalty” if reporters wanted to “keep their jobs.”
How entertainment production hubs are creating new housing hotspots
NewHomeSource reports entertainment production hubs are driving housing demand by boosting local economies, attracting home buyers with modern amenities and community design.
I Turned My Childhood Hobby Into a $2K-a-Month Business. Then I Quit My Corporate Job and Hit $100K+ Month.
Danielle Meyer, founder of Spicy Dan, always had an "entrepreneurial mindset."
Nominate a Capital Region health care executive who’s making a difference
Who’s running the organizations shaping health care in the Capital Region — and doing it well? That’s the question at the heart of the Outstanding Health Care Executive category in Business Report‘s inaugural Excellence in Health Care Awards. This recognition is for the senior leaders who are making the hard calls, building strong teams and […]
Revolutionary Submarine Mysteriously Disappears Without a Trace – Scientists Are Now Preparing for a Bold Return
A pioneering robotic submarine that explored beneath Antarctica’s glaciers has been lost, but its discoveries are reshaping our understanding of ice melt as a more advanced successor is prepared to continue the mission.
Watch sperm whale headbutt another for no apparent reason
Researchers have captured extraordinary footage of sperm whales randomly headbutting each other, confirming anecdotal reports from mariners and whalers in the 18th and 19th centuries.
Apple Reportedly Preparing 'Biggest Set of iPhone Revamps' Ever
Apple is working on "the biggest set of iPhone revamps in the product's history," according to the latest word from Bloomberg's Mark Gurman. Specifically, he is referring to the long-rumored foldable iPhone, as well as an ambitious 20th-anniversary iPhone with a truly "edge-to-edge" design.
Republicans fear this Democrat in Georgia Senate race: ‘This guy’s no slouch’
The Cook Political Report rates the general election as a toss-up.
Trump to Maria Bartiromo: Iran wants to make a deal badly, could be within 5 days or sooner
Maria Bartiromo reports that President Donald Trump says Iran ‘wants to make a deal badly’ as he orders a five-day pause on planned strikes against key infrastructure, signaling ongoing high-level talks and triggering a sharp market rebound.
Live Science Today: Earth hits record energy imbalance, Hawaii floods and NASA prepares for Artemis II launch
Monday, March 23, 2026: Your daily roundup of the biggest science stories making headlines.
Free sports physicals return for public school students in Flagler and Volusia counties
Thousands of middle and high school students in public schools across Volusia and Flagler counties can receive free sports physicals this spring as AdventHealth helps young athletes prepare safely for the upcoming season.
‘President Trump is right’: The White House’s go-to line about Trump’s false claims
President Donald Trump’s White House spokespeople have a favorite two-step reply when reporters ask them to comment on one of Trump’s false claims.
Report: iPhone Air is about twice as popular compared to the Plus model it replaced
According to cellular network data from Ookla, the iPhone Air is about twice as popular compared to the iPhone 16...
Closing the women’s health gap: 5 key focus areas and why they need more research
Only 6% of private investment targets women's health, a World Economic Forum report says. 5 examples show how strategic investments could change this.
The New Party Politics of Abortion
Some Republicans remain consistently pro-life. But under Trump’s lead, the GOP has become an anti-Roe yet pro-choice coalition.
Doubts from key Republicans on surgeon general test MAHA’s political power
Casey Means faces pushback from some Republicans over her refusal to forcefully recommend vaccines.
Women’s health innovation is a huge opportunity Philadelphia is in danger of missing
A booming medical market is creating jobs, research and startup funding, and the region has the talent and institutions to become a national leader, a local entrepreneur writes.
Inside the Turmoil at RFK Jr.’s CDC, as Told by Current and Former Employees
Forty-three current and former C.D.C. employees on the changes they say are replacing science with ideology — and making Americans more vulnerable.
Science should guide Florida’s pesticide conversations
The science on glyphosate exposure is extensive, and the levels reported in bread testing fall well below thresholds associated with harm.
In California, a Republican Sheriff Seizes Ballots, Prompting Concerns
Riverside County Sheriff Chad Bianco, a candidate for governor, recently took possession of more than 650,000 ballots as part of a fraud probe. Election officials say his investigation is baseless.
Stamford cites serious health violations at nine entities in January
Of the more than 30 Stamford businesses inspected in January, nine were cited for serious violations during health inspections, reports show.
Kathy Ireland Accuses Business Managers of Looting Her Fortune
The model-turned-entrepreneur and lifelong Santa Barbara resident claims decades-long deception left her virtually broke.
What’s at stake for UK in May’s local elections: six key questions
Reform, Plaid Cymru, the SNP and the Greens are all banking on big gains and nationwide repercussions
Mum on his own replacement, Bennet disrespects voters
U.S. Sen. Michael Bennet is playing an arrogant game of hide-and-seek with Colorado voters as he seeks to abandon his Senate seat to become governor. Bennet insists that if he is elected governor in November, he will wait until he is inaugurated in January 2027 before he resigns from the Senate so he can unilaterally […]
Obesity report sets out vision for healthy future in Peterborough
A new obesity charter for Peterborough says authorities should look beyond individual behaviour.
Breaking the Cycle review – meet the charismatic Thai politician striving to change his country’s history
Gripping documentary examines the Future Forward Party’s unprecedented 2019 election result, and its leader’s aim to break Thailand’s repeated military coups
Pfeiffer, Pulley Join The Core Entertainment Leadership Team.
The Core Entertainment has added Sarah Pfeiffer as Head of Marketing and Gabriella Pulley as Chief of Staff. Both will report to Co-Founders and Co-CEOs Simon Tikhman and Chief Zaruk
Three Years on, What Have We Learned From the Vogue Business Size Inclusivity Report?
Vogue Business began recording size inclusivity on the runway three years ago. Today, mid and plus-size representation is at an all-time low.
The Vogue Business Fall/Winter 2026 Size Inclusivity Report
Size inclusivity on the runway fell again this season, highlighting how far the industry still has to go.
St. Louis Blues Weekly Prospect Report (March 22)
Jiricek has big scoring week; McIsaac announces future plans; Ralph, Michigan State head to NCAA Tournament with Mayich, Clarkson University eliminated; Peterson scored pair, including a SH beauty for Springfield
2026 Best Business Schools | How Alumni Rate Their Undergraduate Business Degrees
Alumni rate their undergraduate business programs in Poets&Quants’ 2026 ranking, evaluating academic experience, career preparation, advising, and how well their degrees support long-term career goals.
Norman City Council to consider ordinance repeal related to Rock Creek Entertainment District
Norman City Council will consider repealing an ordinance related to the Rock Creek Entertainment District during its Tuesday meeting, according to a council member’s social media post.
3 things to know about new 49ers punter Corliss Waitman
The San Francisco 49ers are replacing Thomas Morstead with Corliss Waitman. Let's get to know the team's new punter before he boots his first ball.
State lawmakers debate new round of business tax cuts
Rep. Joe Sweeney, R-Salem, and Sen. Donovan Fenton, D-Keene, discussed their support and opposition to House Bill 155, which would reduce the business enterprise tax from 0.55% to 0.50%.
Simona Martin: Colorado’s data center boom needs public health guardrails
As AI infrastructure expands across the state, lawmakers face a choice about who bears the costs and risks.
UTA College of Business to connect students, professionals with networking, elevator pitch event
Students, business professionals and recruiters will mingle from 6 to 8 p.m. Monday at the UTA Center for Entrepreneurship and Technology Development.
Florida basketball stunned by Iowa in March Madness Round 2 upset
Florida basketball was stunned by Iowa, ending its hopes to repeat as national champions in the Men's NCAA Tourrnament.
Statue of Christopher Columbus installed on White House grounds
A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.
Two veteran relievers clinch jobs on Diamondbacks' Opening Day roster
Right-handers Jonathan Loaisiga and Joe Ross have made the Diamondbacks' roster for Opening Day. Both will pitch in relief.
The M-Trends 2026 report shows how to strengthen business cybersecurity.
Learn more about the evolving threat landscape based on Mandiant's new M-Trends 2026 cybersecurity report.
Hackaday Links: March 22, 2026
On Friday, Reuters reported that Amazon is going to try to get into the smartphone game…again. The Fire Phone was perhaps Amazon’s biggest commercial misstep, and was only on the market…
How the G.O.P. and Democrats Are Talking About the Surge in Gas Prices
Republicans have largely been on defense against Democratic criticism. Here are five arguments advanced by figures in both parties.
Politics, protests and popular culture: The University of Minnesota community responds to ICE impact through memes and music
Outside Coffman Union on March 3, The University of Minnesota’s Students for a Democratic Society protested Immigration and Customs Enforcement’s presence in Minnesota and on campus, despite reports that Operation...
Fire destroys 30,000 square feet of Aledo plating business, no injuries reported
Michael McCarthy Considering Three Races As Options For Journalism's Return
After Journalism worked five furlongs in company Sunday at Santa Anita, trainer Michael McCarthy said he is looking at three potential races to kick off the colt’s 4-year-old campaign. Journalism could return in either the Oaklawn Handicap (G2) or Ben Ali (G3) at Keeneland, both on April 18, or ...
Federal union says 'untrained' ICE agents shouldn't replace TSA
President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.
Crimson Desert developer apologizes and promises to replace AI-generated art
Pearl Abyss announced a comprehensive audit of its in-game assets and will replace any AI-generated content.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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