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Why REI treats CX as a critical business function
The outdoor retailer is focused on doubling down on its differentiators, REI’s Clay Walton-House said. That means investing in its elevated services and member experience.
A geneticist is studying pythons for clues about human health and longevity
A team of researchers believes that pythons may contain clues to help treat a range of human ailments — from heart disease to muscle atrophy, and more.
When Vermont’s treatment landscape shifts, community providers step up
As Vermont’s substance use treatment landscape shifts, community providers are stepping up to maintain access to care. In Washington County, strong partnerships ensure rapid connection to treatment, recovery services, and coordinated support.
Across Tanzania, Medical Refrigerators Preserve Life and Health for Kids with Diabetes
The technology Tanzania’s children with diabetes needed most urgently wasn’t a cutting-edge treatment. It was refrigeration. Local public health clinics across Tanzania provide monthly checkups for…
New York approves cannabis for anxiety. Science says it may not help
A Lancet Psychiatry study found no evidence cannabinoids treat anxiety, PTSD. In NY, any practitioner can certify a patient for medical cannabis for any condition they deem appropriate.
Scientists See Converging Evidence of Antarctic Ice Retreat
A sediment core spanning millions of years and new modeling studies point to significant ice retreat under temperatures similar to today.
Four Jewish ambulances set on fire in London in what health secretary calls 'sickening' attack
The attack on the Jewish Community Ambulance service in north London is being treated as an "antisemitic hate crime", the Metropolitan Police says.
A promising fatty liver treatment may raise cancer risk
A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.
Opinion | Jesse Jackson, the Prophet Who Became a Politician
He challenged black Americans in the 1960s and ’70s, then retreated into victimhood and grievance.
Chappell Roan pushes back after soccer star Jorginho alleges his daughter was mistreated
Chappell Roan pushes back after a Brazilian soccer player says a guard mistreated his young daughter at a hotel. Jorginho says his 11-year-old recognized Roan at breakfast in São Paulo and got...
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Skin therapy business opening with celebration next month in the Poconos
The new location will offer customized skin rejuvenation treatments, including advanced exfoliation, LED light therapy, and modern facial technologies.
Skin therapy business opening with celebration next month in the Poconos
The new location will offer customized skin rejuvenation treatments, including advanced exfoliation, LED light therapy, and modern facial technologies.
The Next Minecraft Drop Could Be Its Most Chaotic Yet
During Minecraft Live, Mojang treated viewers to a sneak peek at its next game drop: Chaos Cubed.
Norfolk racing driver Will Macintrye feels in 'limbo' over health
Will Macintyre says following chemotherapy treatment his condition got worse.
New AI tool predicts cancer spread with surprising accuracy
Researchers have discovered that cancer spread isn’t random—it follows a kind of biological “program.” By studying colon tumor cells, they identified gene patterns that signal whether a cancer is likely to metastasize. Their AI model, MangroveGS, can predict this risk with about 80% accuracy and even works across multiple cancer types. This could transform how doctors decide who needs aggressive treatment and who doesn’t.
Scientists turn probiotic bacteria into tumor-hunting cancer killers
Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.
Owners of Greenville pet grooming business accused of punching dogs
The Greenville Police Department reports the owners of a pet grooming business were arrested for mistreating animals on Monday.
Four Key Moments: Hearing on Improving Kidney Health Through Better Prevention and Innovative Treatment
WASHINGTON, D.C. – Medicare’s coverage and reimbursement policies for chronic kidney disease (CKD), and its most severe form, end-stage renal disease...
At UN, Holy See allies question reliance on hormonal treatments for women
The event was co-sponsored by the Fertility Education and Medical Management Foundation, a U.S.-based group that created an app that encourages women to track their cycles.
Judge Rules US Government Overreached With Transgender Health Care Declaration
PORTLAND, Ore. (AP) — A federal judge said the government overreached by issuing a declaration that called treatments like puberty blockers and surgeries unsafe and ineffective for young people experiencing gender dysphoria, according to a ruling Thursday in Oregon. Judge Mustafa Kasubhai's ruling ...
Political influence ‘a serious problem’ for FDA under Trump, former commissioner says
Hundreds of individualized treatments for rare diseases could become available over the next decade — but only if government regulators handle the new
New Cholesterol Guidelines: The No. 1 Thing Young People Can Do Now to Boost Heart Health
New cholesterol guidelines offer opportunities to not just treat disease, but to get ahead of it.
Interventional radiology breakthrough in portal vein thrombosis treatment
A UCLA Health interventional radiologist has successfully performed the first pediatric percutaneous spleno-renal shunt procedure to treat severe portal hypertension in a 6-year-old patient. This minimally invasive procedure aims to relieve complications associated with portal vein thrombosis, showing promising long-term outcomes.
Weight-loss treatment is on the verge of a dramatic shift
About 10 weeks after it was approved, the Wegovy pill is now estimated to be part of the daily regimen of about 400,000 Americans. And the field of weight-loss treatment is on the verge of even more head-spinning change.
Opinion: The Barrier to ALS Precision Drugs Isn’t Science. It’s the ‘Valley of Death’
As Congress debates renewing the Act for ALS, it must prepare for the coming era of precision ALS medicine by prioritizing early-stage research to more quickly bring effective treatments to the market.
UC-created algorithm can help treat chronic health condition
High blood pressure affects about half of U.S. adults.
Healthy Returns: Stopping GLP-1s raises risk of heart attack, stroke and death, study says
Research finds that even short gaps in treatment with a GLP-1 can drive up risks of heart attack, stroke and death in patients with Type 2 diabetes.
Thymus may be critical to adult health
Research indicates the often-overlooked organ can be key predictor in longevity, disease risk, and cancer treatment outcomes.
Study Finds Little Proof Cannabis Helps Most Mental Health Conditions
By HealthDay Staff HealthDay ReporterWEDNESDAY, March 18, 2026 (HealthDay News) — Cannabis-based medications are often used to treat mental health problems, but a new review suggests they may not work as well as many people hope. Researchers looked at decades of studies and found little evidence ...
Large Medical Cannabis Review Finds Scarce Evidence It Treats Mental Health Disorders
We know so very little.
What to know about Bill Gates’ nuclear science company planned for the former South Philadelphia refinery site
TerraPower Isotopes will manufacture a rare, radioactive isotope for use in developing cancer treatments.
Nasal Swab Test Spots Early Alzheimer’s Signals
DURHAM, N.C. – Alzheimer’s disease affects millions of people worldwide, yet the illness is hardest to catch at the very beginning, when new treatments may work best.In a new study, Duke Health researchers show that a quick, outpatient nasal swab can pick up early biological changes linked to Alzheimer’s, even before thinking and memory problems appear.
Paleontology has an Epstein problem. Women in the field say it's a symptom of a deeper misogyny
The names of hundreds of scientists have appeared in the Epstein files, including prominent dinosaur researchers. As the paleontology community reckons with the fallout of these revelations, women in the field say it's bringing to the forefront what they've known for years — that paleontology is ripe with abuse and harassment, and its institutions protect men at the top at the expense of women trying to build careers in spaces that treat them as disposable.
Sparse evidence for cannabis to treat mental health conditions highlights research gap
A new analysis represents the largest effort yet to systematically parse all the data from high-quality clinical trials on cannabis and mental health. The evidence is lacking.
National Eye Institute director speaks during Vision Science Research Center retreat
National Eye Institute director speaks during Vision Science Research Center retreat
Could a ‘digital twin’ help you get better health care?
Scientists are working to create "digital twins" of patients that they can test treatments on, in hopes of delivering personalized health care.
Reproductive health clinics scramble as Title X funding cliff approaches
Title X is a 56-year-old federal grant program that supports thousands of clinics that provide birth control and STI testing and treatment around the country. Now those clinics could face a funding gap because of a Trump administration delay.
Psychiatrists’ Use of Biomarkers Could Open a New Window Into Mental Health Diagnoses
The world’s largest professional psychiatry organization is preparing for the day when biological indicators can help diagnose and treat mental illness.
The scientist who warned that profit, not science, decides which drugs reach patients
In a Genomic Press Interview published in Brain Medicine, Dr. Gabriella Gobbi, Professor of Psychiatry at McGill University, Canada Research Chair (Tier 1) in Therapeutics for Mental Health, and President-Elect of the Collegium Internationale of Neuropsychopharmacology (CINP), delivers a pointed warning: the greatest threat to drug discovery is not scientific failure but a financing system that abandons effective, affordable treatments whenever they cannot promise sufficient returns to investors. Across a career that began in central Italy and moved through Sardinia and Montreal, Dr. Gobbi has generated landmark research linking adolescent cannabis exposure to depression, identified novel melatonin receptor mechanisms in sleep and pain, and launched psychedelic neuroscience before it became fashionable. The interview reveals a scientist whose best questions have always begun at the bedside, and whose most urgent fears concern the structures that stand between discovery and patients.
Cannabis is not an effective treatment for common mental health conditions, says review
International researchers find ‘very little evidence’ medical form of the drug can treat anxiety, anorexia and other disorders
Live Whole Health #309: Natural pain relief
Experts recommend non-drug methods of managing low back pain as a first line of treatment, and yoga is on the list of safe and effective ways to manage pain.
Cue Biopharma Reports Fourth Quarter and Full Year 2025 Financial Results and Business Highlights
Advanced research and development of CUE-401 for IND (Investigational New Drug) readiness –CUE-401 is the Company’s lead asset for the treatment of autoimmune and inflammatory diseasesAppointed industry veteran Lucinda Warren as Chief Financial and Business OfficerRaised net proceeds of $10.2M through an underwritten public offeringAnnounced strategic collaboration and license agreement with ImmunoScape to develop breakthrough cell therapy approach for solid tumors – Entitled to receive upfront
New obesity statistics highlight importance of preventive cardiology
Cardiovascular health is much worse in some parts of the United States than others. Cardiologists in those high-risk areas can make a world of difference by embracing preventive cardiology and working to treat patients before it is too late.
First case of severe mpox disease reported in major city: ‘Life-threatening’
First severe mpox clade I case identified in NYC resident who traveled abroad. Health officials say local transmission risk remains low for the community.
UPMC warns embattled data exchange Health Gorilla may have improperly pulled patient records
UPMC says its medical records may have been improperly accessed by Health Gorilla, a patient data gatekeeper accused in federal court of mismanaging sensitive information. Health Gorilla requested data “under the pretext of providing treatment to shared UPMC patients and claimed it had permission to do so,” according to a
State Announces Intent to Award $20 Million to Santa Barbara County for New Behavioral Health Residential Facilities in Santa Maria
Funding Through California’s Behavioral Health Continuum Infrastructure Program Will Support Two 16-bed Community Residential Treatment Facilities Focused on Diversion and Recovery
Susie Wiles, White House chief of staff, has breast cancer, Trump says
The president announced the White House chief of staff’s diagnosis Monday, saying she has a good prognosis and will continue to work while receiving treatment.
Partisanship and science
I recently participated in a symposium of the Denver-based Institute for Science & Policy, during which I had a “fireside chat” with Tony Mills of the American Enterprise Institute. Mills has written extensively on the politicization of science, and the two of us had a very enjoyable hour-long conversation on the topic. You can watch it below. The main questions we dealt with are why there is such a vast partisan gap in trust of science, and to what extent this is a unique moment. Mills helpfully brings a good deal of data to the discussion, as he did in this useful piece at Issues in Science & Technology. Tusk depends on reader support. To support this work, please become a paid subscriber. Subscribe Note this graph, drawing on a range of survey data to demonstrate partisan attitudes toward science since 1970s. As it demonstrates, there’s been a very sharp partisan divergence in confidence in science during the Trump Era, starting prior to the Covid pandemic. At least in part, we can attribute this to a rise in populist anti-science rhetoric embraced by Trump, his appointees, and those in his media orbit. But as the graph also shows, the partisan divide has existed in the past, and it’s not always in the same direction. The largest divergence in party views toward science prior to 2016 was in the 1970s, when liberals equated scientific achievement with the military-industrial complex and thus trusted it less. That era of scientific mistrust is often overlooked. Indeed, as Mills notes, the Moon landings (1969-72), which today are considered one of the last great moments of national unity, were experienced nothing like that at the time. There was sharp debate back then over whether the Apollo missions were worth the vast expenditures when the country had so much else to deal with. It’s outside the dataset, and we don’t have the partisanship lens for it, but the 1950s was another deeply anti-science decade, with critics of intellectuals and college professors alleging their ties to communism and their lack of commitment to basic American moral beliefs. This was the subject of Richard Hofstadter’s 1962 book Anti-Intellectualism in American Life, in which he quotes religious leaders like Franklin Graham: [In place of the Bible] we substituted reason, rationalism, mind culture, science worship, the working power of government, Freudianism, naturalism, humanism, behaviorism, positivism, materialism, and idealism. [This is the work of] so-called intellectuals. Thousands of these “intellectuals” have publicly stated that morality is relative—that there is no norm or absolute standard.… This fervor was heavily whipped up by Sen. Joe McCarthy (R-Wisconsin), although it’s clear that not all his fellow Republicans were on board with his red-baiting. What ended that era? The simple answer is the 1957 launch of Sputnik. Americans became afraid that they were losing to Soviet scientists, and suddenly university researchers and government projects were awash with funding. In our conversation, I asked Mills about the possibility of us having a Sputnik moment again that would rally the American public in favor of science today. Mills argued that the COVID-19 pandemic was essentially a Sputnik moment — a terrifying threat to all Americans that required scientific advances to address. But thanks in part to political polarization and the populist and conspiratorial leanings of Donald Trump, we got the opposite of a unifying moment. Many Americans turned against science, despite science actually stepping up in that moment. As we discussed in the chat, it’s not clear what scientists could or should be doing in this moment to increase faith in their work. As Mills notes, one of the chief complaints against scientists and professors is that they’ve become too political; scholars becoming even more political might not help them achieve their goals. This (mainly Republican-driven) anti-science era will end, of course, but it’s not clear what event will bring that about. Share
Op-Ed: Sherrill's misguided retreat on smart business tax policy
Fifteen years ago, Republicans and Democrats agreed to make New Jersey more competitive. Now, the governor wants to push us backward
Dartmouth Health to open new addiction treatment center in Claremont
Dartmouth Health opens an outpatient addiction treatment center at Valley Regional Hospital in Claremont, providing convenient and timely care.
As mental health crisis grows, legal skirmish around treatment persists in Orange County
Even if a lawsuit between the county and the nonprofit that runs Be We OC ended today, the county would still struggle to treat about 40,000 indigent residents who suffer extreme mental illness.
Is stem cell therapy the next frontier to treat diabetes? Louisiana experts aren't convinced.
Personalized therapies for diabetes, while showing promise in international studies, is met with healthy skepticism from Louisiana experts. "Maybe in 20 years," a doctor at LSU Health says. Here's what to know now.
Thousands of people disabled by long COVID seek answers
Six years after the COVID-19 pandemic began, doctors are still treating long COVID patients with complex symptoms and unknown futures.
Intermountain Health employee pleads guilty after stealing 100+ prescriptions from Colorado patients
A former employee of Intermountain Health in Colorado has pleaded guilty after she stole more than 100 prescriptions from patients being treated for significant pain.
Textbooks were wrong: Scientists reveal the surprising way human hair really grows
Hair may grow in a completely different way than scientists once believed. Instead of being pushed out from the root, new research shows that moving cells inside the follicle actually pull the hair upward like a microscopic motor. Advanced 3D imaging revealed a spiral movement of cells that generates this force. The finding could change how scientists study hair loss and design future treatments.
This doctor treated migrants’ severe injuries at the US-Mexico wall: ‘Political decisions made it as violent as possible’
Dr Brian Elmore witnessed a public health crisis unfold at the border near El Paso. He reflects on why it was like a ‘perverse Groundhog Day’
Pasqual's in Verona closing, Easter treats, and a new NBA record
The Cap Times' new Food & Culture newsletter shares Madison area restaurant news, with recommendations for what to read, watch, listen and eat.
America has health alarm fatigue. I know because I treat it
“We cannot let alarm fatigue silence the response to Kennedy’s and Trump’s destruction,” writes Robert Shpiner.
How Golden Entertainment (GDEN) Narrative Is Shifting As Analysts Reassess Risk And Reward
Golden Entertainment’s latest analyst update keeps the fair value target steady at $30.50, even as assumptions behind that figure shift. Bullish and bearish voices are now reading the same unchanged headline number in very different ways, with some seeing headroom for upside and others treating it as a signal that the risk or reward balance has cooled. As you read on, you will see how these views are forming and how you can track the story as it continues to evolve. Analyst Price Targets...
A major change could be coming in mental health diagnoses, psychiatrists say
The world’s largest professional psychiatry organization is preparing for the day when biological indicators help diagnose and treat mental illness.
Woman tests how Home Depot workers treat her in a “hot girl” outfit vs dressed “like a boy”
Does pretty privilege apply at the hardware store?
Depression may start with an energy problem in brain cells
Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy molecules at rest but had trouble increasing energy production when needed. Scientists believe this imbalance may contribute to symptoms such as fatigue and low motivation. The finding could help pave the way for earlier diagnosis and more personalized treatments.
Breakthrough to Strengthen Bones Could Reverse Osteoporosis
A potential treatment for millions.
Republicans Concede They Need a Pivot on Immigration Ahead of Midterms
In public comments and private meetings at a House G.O.P. retreat, top officials allowed that President Trump’s immigration crackdown had hurt the party and that they needed a course correction on the issue.
Health Care Roundup: Market Talk
Gain insight on eczema treatments, Roche Holding’s recent pipeline updates and more in the latest Market Talks covering the health care sector.
Healthcare Uses Specialized Language. It Needs Specialized AI, Too.
The potential generative AI in healthcare is enormous. They can generate patient education materials or clinical notes in seconds, flag incomplete documentation to keep care on track, or even suggest differential diagnoses . But when generalist models encounter the specialized “dialects” used across medical fields, they can miss critical clinical meaning—even when they read every word correctly. The result can be flawed decisions and eroding clinician trust. Healthcare organizations should treat AI like a supervised trainee: adapt models to clinical specialties, require transparent reasoning, and calibrate automation with human oversight.
Federal officials walked back claims on leucovorin. Here’s what families should know now
The drug leucovorin was touted by the Trump administration in September as a potential treatment for thousands of children with autism. Now, some parents and guardians of children with autism say they feel abandoned by the US Food and Drug Administration’s new stance on leucovorin.
How to Solve One of the Most Expensive Problems in Employer Healthcare
A small share of employees drives a disproportionate share of employer health-care spending: They are patients whose complex conditions go undiagnosed as they cycle through a fragmented care system. A diagnostic-focused “center of excellence” model—such as the Mayo Clinic Complex Care Program—offers a different approach: coordinated, multidisciplinary evaluations that identify the right diagnosis quickly. Evidence from employer claims shows that earlier, accurate diagnoses can improve outcomes, reduce unnecessary procedures, and lower costs by shifting care from repeated testing toward targeted treatment.
Minerva Neurosciences Reports Fourth Quarter and Fiscal Year 2025 Financial Results and Business Updates
Initiation of confirmatory Phase 3 trial with roluperidone for negative symptoms of schizophrenia is planned for Q2 2026, with topline data anticipated in 2H 2027BURLINGTON, Mass., March 11, 2026 (GLOBE NEWSWIRE) -- Minerva Neurosciences, Inc. (Nasdaq: NERV), a clinical-stage biopharmaceutical company focused on the development of therapies to treat central nervous system (CNS) disorders, today provided business updates and reported financial results for the fourth quarter and year ended Decembe
Oil prices retreat, Asian shares rise after report of planned IEA oil reserve release
International Energy Agency reportedly proposed argest release of oil reserves in its history to bring down crude prices
Regeneron Science Talent Search 2026 Recognizes America’s Top Young Scientists, Awarding More Than $1.8 Million to High School Seniors for Innovative Research in Computational Mathematics, Neural Science, and Blood Cancer Treatment
$250,000 top award goes to Connor Hill in America’s longest running and most distinguished science and math competition Top $250,000 Regeneron Science Talent Search Winner Named Regeneron and Society for Science announced that Connor Hill, 17, of State College, Pennsylvania, won the top award of $250,000 in the 2026 Regeneron Science Talent Search (STS), a program of Society for Science. TARRYTOWN, N.Y. and WASHINGTON, March 10, 2026 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. and Societ
FDA declines to endorse leucovorin for autism, walking back earlier statements suggesting benefit
The prescription drug leucovorin is getting a label update, though it’s not what that the US Food and Drug Administration suggested might be coming during a White House briefing in September, when officials touted the drug as a potential treatment for thousands of children with autism.
Scientists discover molecule that stops aggressive breast cancer in its tracks
Scientists at Oregon Health & Science University have developed a new molecule that could open the door to treating triple-negative breast cancer, one of the most aggressive and difficult-to-treat forms of the disease. The compound, called SU212, targets and disables a key enzyme that cancer cells rely on to fuel their growth. In tests using humanized mouse models, the molecule caused tumors to shrink and slowed the spread of cancer by forcing the enzyme to break down.
Cancer Haunts Neighbors of Canada’s Oil Sands Wastelands
Though high rates of the disease persist among the nearby Indigenous communities, the Canadian government is weighing rules that may allow energy giants to release treated mining waste into the river system.
Cannabis compounds could reverse disease affecting one-third of adults
Compounds found in cannabis could provide a new roadmap for treating the world’s most common chronic liver disorder, according to a study released by the Hebrew University of Jerusalem.
Trump Threatens to Crowd Out Republicans’ Midterm Message
As the G.O.P. gathered in Miami for a party retreat where lawmakers hoped to focus on the economy, the president was threatening to block his own party’s legislative agenda.
trawberry Festival draws crowds, sweet treats, entertainment
It was a “berry” sweet weekend at Floral Park in Floral City as tens of hundreds of people packed into the park for the 39th Floral City Strawberry Festival Saturday
Hims & Hers Announces Strategic Shift for US Weight Loss Business
Starting with a new collaboration with Novo Nordisk, the company announced plans to align its US and global strategies with a focus on an increasing variety of FDA-approved GLP-1s Hims Hers Health, Inc. (NYSE: HIMS) today announced a collaboration with Novo Nordisk as part of a new strategy for weight loss care treatments involving GLP-1s, evolving its US offering to match the company’s approach globally. In the US, the company now plans to provide GLP-1 customers with access to a broad assortment of FDA-approved medications and offer compounded semaglutide through the platform on a limited scale. By aligning its domestic and international models in weight loss, Hims Hers will become the largest global consumer health platform for access to more affordable, approved medications. The US weight loss landscape has transformed dramatically since Hims Hers entered the market in 2023. Progress in the industry has made a broader range of FDA-approved GLP-1 treatments
$106M 'mental health village' in Norwalk breaks ground: What to know
LA County has officially broken ground on a first-of-its-kind "Care Community" at the Metropolitan State Hospital campus, turning vacant buildings into 162 beds of treatment and housing.
Seattle clinic gets homeless youth engaged in care by treating their pets
A clinic at the New Horizons Youth Shelter treats young people alongside their pets to build better relationships with the medical system — with promising results.
San Antonio archbishop: Profit, politics play roles in inhumane migrant treatment
"These detention centers … cannot have empty beds, because otherwise they don't make money," said Archbishop Gustavo García-Siller. "It's business, business, business, business, business."
Letters to the Editor: A free market inherently doesn’t work when it comes to healthcare
'Providers are required by law to treat patients, and sick or injured people are hardly in a position to walk away if the treatment is a little more costly than they would like,' writes an L.A. Times reader.
Scientists discover protein that triggers diabetic blindness
A newly identified protein may hold the key to preventing diabetic blindness. Researchers discovered that LRG1 triggers the earliest damage in diabetic retinopathy by constricting tiny retinal blood vessels and reducing oxygen supply. In mice, shutting down this protein stopped the damage before it could take hold. The finding could pave the way for treatments that protect vision before symptoms ever begin.
Controversial top vaccine regulator to depart FDA
Vinay Prasad, the top regulator overseeing vaccines and complex treatments for difficult diseases, had previously lost his job in July before getting it back less than two weeks later.
SAMHSA Announces More Than $69 Million in Funding Opportunities for Serious Mental Illness and Suicide Prevention Grant Programs
SAMHSA announced $69.1 million in funding for: the Children's Mental Health Initiative (CMHI), Zero Suicide, and Assisted Outpatient Treatment (AOT).
L.A. County transforms vacant buildings into ‘mental health treatment village’
Los Angeles County leaders are breaking ground Friday on a new mental health treatment complex that will transform long-vacant buildings on a historic Norwalk hospital campus into a “village” for c…
Bringing advanced neurological care to South Texas families - UT Health San Antonio
“We’re not only treating conditions — we’re caring for people across the full spectrum of brain health. When someone hears the words, “You have ALS,” or “This may be dementia,” life changes instantly. Questions come faster than answers, appointments multiply and the future feels uncertain. For patients and families navigating that uncertainty, UT Health San […]
Adial Pharmaceuticals Reports 2025 Fiscal Year Financial Results and Provides Business Update
GLEN ALLEN, Va., March 06, 2026 (GLOBE NEWSWIRE) -- Adial Pharmaceuticals, Inc. (NASDAQ: ADIL) (“Adial” or the “Company”), a clinical-stage biopharmaceutical company focused on developing therapies for the treatment and prevention of addiction and related disorders, today provided a business update and reported its financial results for the 2025 fiscal year ended December 31, 2025. Key Highlights: Regulatory Progress: Achieved positive clinical study results from the AD04-103 pharmacokinetics (P
Friday briefing: Can the politics of cruelty around asylum help Labour in the polls?
In today’s newsletter: Labour’s new asylum framework marks a decisive shift in how the UK treats people granted protection and exposes tensions between electoral strategy, public service pressures and the party’s historic commitments to human rights
San Antonio archbishop: Profit, politics play roles in inhumane migrant treatment
(OSV News) — Days after a meeting among several Catholic bishops serving along both sides of the Texas-Mexico border — a regular gathering for the “Tex-Mex” bishops — OSV News spoke…
Tylenol orders for some pregnant women fell after Trump said to avoid it
New research found that Tylenol orders fell for pregnant women who visited the E.R. in the months after Trump’s statements. Prescriptions rose, meanwhile, for leucovorin, a drug the administration touted as a potential autism treatment.
How does hair loss differ between men and women?
Learn how men’s and women’s hair loss is treated differently and what you can do to prevent it.
Patient health data as a public utility: A former ARPA-H data chief explains
Patients generate vast health data, but private companies monetize it. A policy group proposes treating the data like a regulated utility.
Brain Tech Startup Science Corp. Raises $230 Million to Treat Blindness
Neurotechnology company Science Corp. raised $230 million from investors to commercialize its implant for blindness and develop even more advanced brain devices.
Six federal scientists run out by Trump talk about the work left undone
Federal data shows the NIH lost about 4,400 people — more than 20% of its workforce. Scientists say the departures harm the U.S.’ ability to respond to disease outbreaks, develop treatments for chronic illnesses, and confront the nation’s most pressing public health problems.
Slowing Huntington’s disease: how science advice enabled a breakthrough treatment
A coordinated research effort shows how science advice and shared infrastructure can help turn new ideas into meaningful progress for people and communities.