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Mental Health Board faces forks in the road - Illinois Times, the capital city's weekly source of news, politics, arts, entertainment, culture
Some community members, including the former Massey Commission’s managing director, say the inaugural Sangamon County Mental Health Board has to better address the communities it is attempting to support if the board wants to be successful. Since the Mental Health Board began meeting monthly at the end of May, some of the specific asks have […]
Giants Trade Pitch Sends Former 1st-Round Pick to 49ers
Bleacher Report proposed a trade that would send New York Giants former 1st-round pick to 49ers. The post Giants Trade Pitch Sends Former 1st-Round Pick to 49ers appeared first on HEAVY.
Should the Miami Heat Sign Former National Champion?
As Memphis prepares to waive Walter Clayton Jr., the Miami Heat could leverage their proven developmental system to transform the former Florida star into the next high-impact guard.
First office-to-apartment conversion in city’s $250M push to remake the Loop opens
The redevelopment is the first of five projects to be completed in the city’s LaSalle Corridor Revitalization initiative, which launched in 2022 under former Mayor Lori Lightfoot.
LSU finalizes 2026 roster, will not add former NFL players
The Tigers added two more players to their roster to reach the 105 limit, meaning they will not be adding any former NFL players.
Ex-Rangers Player Helped Celtic Complete Summer Signing
It looks like the former Rangers player helped Celtic complete the summer signing.
Two Tiny Lifeforms Built a Bridge Too Small to See—and May Have Made Humanity Possible
Stromatolites, formed by microbial mats, hold evidence of a symbiotic relationship that possibly kickstarted complex life billions of years ago.
Gov. Andy Beshear says arrest of former Gov. Matt Bevin shows 'the rule of law still applies'
Political figure and U.S. army veteran Bruce Lunsford dies
Bruce Lunford, a former Democratic gubernatorial and Senate candidate, has passed away.
Jake Paul Teases Michael Page Signing for MVP MMA
Fight promoter Jake Paul teased a potential signing of former UFC fighter Michael Page to the MVP MMA roster.Page completed his six-fight UFC contract with a unanimous decision win over Nursulton Ruziboev at UFC Paris. However, he was heavily criticized by fans for putting on another boring fight, which was not the first time he’s […] The post Jake Paul Teases Michael Page Signing for MVP MMA appeared first on HEAVY.
Malone targets EFL return after non-League spell
Former Crawley Town left-back Scott Malone is hoping to use a training camp for free-agent players to attract League Two interest.
Sleepy Hollow boiler business sues CT competitor
A Sleepy Hollow industrial boiler business claims that a former employee and a competitor have taken its trade secrets. Miller
Saints Sign Former Unclaimed Broncos Player From 4 Free Agents
With the opener right around the corner, New Orleans brought a handful of former vets in for a look on Tuesday, quietly trying to shore up the depth chart behind Chris Olave.It’s no secret that New Orleans is leaning heavily on young receiving corps behind Olave, making a late-week workout session with the free wideout […] The post Saints Sign Former Unclaimed Broncos Player From 4 Free Agents appeared first on HEAVY.
With Sununu vs. Pappas, familiar names will compete in New Hampshire Senate race
Republican John E. Sununu, a former U.S. senator, and Democrat Chris Pappas, a member of the U.S. House, are vying to replace U.S. Sen. Jeanne Shaheen, whose decision not to seek reelection created a cascade of competitive races.
Former Angels, Braves 5.60 ERA reliever released by Athletics
The left-hander has pitched for three MLB teams in 2026.
Penn State Legend Micah Parsons Opens Up About Injury Recovery
Former Penn State Nittany Lions star pass rusher Micah Parsons has spoken out about his ACL recovery process.
Former DINK: My lifestyle changed less than I expected after baby
I feared motherhood came with an expiration date for freedom. Then I had my son and realized my life didn't need to change as much as I had expected.
Is David Beasley the most interesting second act in politics?
Former South Carolina Gov. David Beasley, known for his principled stance on removing the Confederate flag and his leadership as UN World Food Programme head, launched the Breaking Bread Together m…
Diamondbacks release former Twins, Phillies .736 OPS outfielder
This comes as no surprise for the Diamondbacks.
Phoenix Suns 2026-27 Player Profile: Miles Bridges
The former Hornets star transitions into a starting role alongside Dillon Brooks, bringing explosive athleticism and defensive potential to a high-stakes season under head coach Jordan Ott.
The moon may have formed in just 5 hours, new simulations suggest
Novel simulations, which reassessed the ancient collision between Earth and the protoplanet Theia, suggest that the moon could have emerged from the aftermath of this impact much more quickly than scientists previously thought.
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
Ben Roethlisberger raises concern over Steelers thin running back room
Former Steelers QB Ben Roethlisberger questioned team's roster construction, warning that depth behind the primary running backs is dangerously thin.
Hoping customers would return after Operation Metro Surge, immigrant businesses are still waiting
These anecdotal reports match preliminary data from government and other researchers.
Former Sunnyvale resident pleads guilty to health care fraud
Authorities say Sevindik Huseynov aided and abetted as scheme to submit thousands of bogus claims to Medicare Advantage programs.
GameSquare Enters Definitive Contribution Agreement to Acquire Sports, Music and Entertainment IP Assets from FanEngine
Highly profitable transaction expected to be immediately accretive to earnings and support multiple recurring revenue opportunitiesFanEngine's assets add well-known global IP assets Peaky Blinders, Simon's Cat, The Two Robbies and Friends, 4Cast Media Platform featuring Former England Captain Ben S…
Cleveland Clinic and Allegheny Health Network former CEOs join Tennr as industry advisors
/PRNewswire/ -- Tennr today named Dr. Toby Cosgrove, former president and CEO of Cleveland Clinic, and Cindy Hundorfean, former president and CEO of Allegheny...
Guardians’ Former Superstar Closer Gets Harsh Update After Gambling Scandal
Cleveland Guardians three-time All-Star Emmanuel Clase was subject to a legal denial after allegations of betting on baseball.
Mac Allister 'spoke brilliantly'
Former Chelsea and Everton winger Pat Nevin says Liverpool midfielder Alexis Mac Allister "said exactly the right things" when telling media that he is "very sad" not to have been offered a new deal by the club. The Argentine, who joined on a five-year contract from Brighton in June 2023, saw team-mates Dominik Szoboszlai and Ryan Gravenberch extend their Reds deals this year. "I often hear various players saying things and pushing things a certain way and you get a bit fed up with it," Nevin told BBC Radio 5 Live's Football Daily podcast.
Scientists in Switzerland made a sponge from cheesemaking waste that captures gold from discarded electronics — after dissolving metal parts from 20 old computer motherboards, they recovered enough to melt into a 22-carat gold nugget
A Swiss lab transformed dairy waste into a gold-recovery tool, extracting precious metal from e-waste that most recyclers leave behind.
How the Texas Attorney General Got This Way
Greg Abbott and Ken Paxton transformed the role from bureaucrat to culture warrior. What comes next?
Fishing the Good Fight supports men facing mental health challenges
Former University of Alabama football player Jennings Hester founded the nonprofit Fishing the Good Fight to provide men with mental health support through fly fishing retreats and community activities.
This week in Santa Cruz County business: Paystand branches into AI agents; court hearing for former Scotts Valley executive; Barilla snaps up Goodles
In this week's survey of local business, Jessica M. Pasko reports on the rollout of a new AI tool for Santa Cruz-based fintech company Paystand, notes a court date for a former executive of Scotts Valley's Ambient Photonics and runs down other numbers, names and dates to know.
The Establishment Pulls Through: Five Takeaways from the New Hampshire Primaries
The U.S. Senate race will feature familiar faces: former Senator John E. Sununu and Chris Pappas, a four-term congressman. Stefany Shaheen, a senator’s daughter, eked out a win in a House primary.
Report that Netanyahu was warned before October 7 triggers political earthquake in Israel
An investigation published by 'Haaretz' claims the Israeli prime minister was informed by UAE President Mohamed bin Zayed, 10 days before the attack, that Hamas was planning a major operation against Israel.
A rare thing in American politics may happen in Rhode Island on Wednesday
Gov. Dan McKee barely beat Helena Foulkes in 2022. For Wednesday’s rematch, the former CVS executive has outraised him and appears well positioned to win.
Brugge win 'can't be underestimated'
Former Chelsea and Everton winger Pat Nevin says you "can't underestimate the importance" of Aston Villa's 3-2 Champions League win over Club Brugge on Tuesday "for their entire season". Villa breathed life into their season as they edged to a narrow Champions League victory which marked their first win and first goals of the campaign. "Just to score some goals is important for Villa," Nevin told BBC Radio 5 Live's Football Daily podcast.
Former Washington head coach blasts NFL owners
Former Washington coach Jay Gruden sounds off on the greed of NFL owners.
Down with Politicians! A Reformed Critique of a Bad Idea
Calvin went so far as to characterize the work done by civic officials as a "sacred and noble calling."
'I cannot take my eyes off Bouaddi
Ayyoub Bouaddi belied his age with a mature Champions League performance on his first Manchester City start to showcase why the club were so intent on signing the 18-year-old. Erling Haaland will take the plaudits for his two goals, but it was Bouaddi who caught the eye with a tidy and assured performance in the middle of the park, signalling early signs that Rodri may not be too sorely missed after his departure. "His age, his game – he looks absolutely born to do it," former Chelsea winger Pat Nevin said on BBC Radio 5 Live during the game.
Jammin’ with Jamstar
Local band Jamstar performed for the crowd at the historic Winchester Speedway on Saturday night as a part of the World Stock Car Festival.
Tucker Kraft named team captain for Packers
GREEN BAY, W.I. (KELO) — Timber Lake native and former SDSU Jackrabbit Tucker Kraft was named one of five team captains for the Green Bay Packers ahead of the 2026 season. This is Kraft’s second season as an offensive captain for the Packers. This Sunday against the Minnesota Vikings Kraft is set to make his […]
Brendan Schaub Trashes UFC 332 Main Event
Former UFC heavyweight fighter Brendan Schaub trashed the upcoming UFC 332 main event between Natalia Silva and Wang Cong.With Valentina Shevchenko out for one year due to injury, she was forced to vacate the UFC women’s flyweight title, so Silva and Wang will now fight for the undisputed strap in the UFC 332 headliner.It’s a […] The post Brendan Schaub Trashes UFC 332 Main Event appeared first on HEAVY.
49ers former 2nd-rounder suffers devastating injury days before opener
The San Francisco 49ers' already thin defensive line sustained a devastating blow just days before their Week 1 kickoff vs. the Los Angeles Rams.
Former Celtics Forward Finds New Team After Boston’s Roster Overhaul
A former Celtics forward has found a new team after Boston’s offseason overhaul left him without a clear role. The post Former Celtics Forward Finds New Team After Boston’s Roster Overhaul appeared first on HEAVY.
LSU Will Not Roster Former NFL Players Wright, Harris
It’s unclear if de-escalation will be enough to end the litigation altogether.
David Brooks argues against political radicalism on YPU floor
David Brooks, a former New York Times columnist who became a presidential fellow in February, spoke in favor of the resolution, “Political Radicalism is Cowardice.” After arguments ranging from Edmund Burke to climate change, the resolution failed.
Undefeated Anthony Wint Books Second UFC Fight in 43 Days
Former NFL player Anthony Wint has booked his second UFC fight in 43 days. The undefeated athlete out of Homestead, Florida, fights on the UFC 332 card on October 3 in Salt Lake City, Utah. He takes on promotional newcomer Lucas Armand in the heavyweight division. The UFC announced the fight on the Dana White’s […] The post Undefeated Anthony Wint Books Second UFC Fight in 43 Days appeared first on HEAVY.
SBA promotes CHOICE Arrangements for small-business health benefits
The SBA and CMS are promoting CHOICE Arrangements, formerly known as ICHRAs, as an alternative health benefits model for small businesses.
SBA promotes CHOICE Arrangements for small-business health benefits
The SBA and CMS are promoting CHOICE Arrangements, formerly known as ICHRAs, as an alternative health benefits model for small businesses.
LSU announces final decision on adding former NFL players
The biggest storyline in college football over the past few weeks has been LSU and head coach Lane Kiffin’s attempts to add multiple players to its roster who had signed NFL contracts and spent time with NFL teams this preseason. Now, LSU has made a final decision on that matter. With the looming threat of…
Baker Mayfield Cashes In Ahead of Browns Reunion
Former Cleveland Browns quarterback Baker Mayfield just cashed in with a massive payday. The post Baker Mayfield Cashes In Ahead of Browns Reunion appeared first on HEAVY.
Denver Broncos Part Ways With Injury-Prone Former Draft Pick
The Denver Broncos have parted ways with a talented but injury-prone former draft pick. The post Denver Broncos Part Ways With Injury-Prone Former Draft Pick appeared first on HEAVY.
September 8 Locker Room with Dexter McNabb
GREEN BAY, Wis. (WFRV) – The first episode of Local 5’s “Locker Room” aired live on Tuesday, kicking off the start to the 2026 NFL season. This week’s guest was former Green Bay Packers fullback Dexter McNabb, who played for the team during the 1992 and 1993 season. He then took a gap year and […]
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a four-term Democratic congressman, will face off against Republican and former U.S. Senator John E. Sununu.
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a moderate Democrat and current Congressman in the 1st Congressional District, will face off against Republican and former U.S. Senator John E. Sununu.
Chris Pappas Defeats Progressive Challenger in New Hampshire Senate Primary
Mr. Pappas, a moderate Democrat who has served four terms in the House, will face former Senator John E. Sununu, the Republican nominee, in November.
Rep. Chris Pappas will face former Sen. John E. Sununu in New Hampshire Senate race, CNN projects
Democratic Rep. Chris Pappas will face Republican former Sen. John E. Sununu in the race for New Hampshire’s open Senate seat, CNN’s Decision Desk projects.
Classic, luxury car business plans to move into old Stevenson Lumber building
MONROE, Conn. --- Carsation, a used car dealership specializing in classic and luxury automobiles, from Porsches and Mercedes to BMWs and Land Rovers, plans to renovate the former Stevenson Lumber building at 1545 Monroe Turnpike to display its cars in a showroom for customers, though the vast majority of its business is done online. Duane
Incumbent GOP governor rolls to primary victory after keeping Trump at a distance
Kelly Ayotte cruised past Republican primary challengers, setting up a high-stakes New Hampshire governor's race against Democrat Cinde Warmington.
Hornets sign former Utah Jazz standout to Exhibit 10 contract
The Charlotte Hornets signed former Yale guard Bez Mbeng to an Exhibit 10 contract.
Billy Joel mourns friend and former drummer Jon Small
NEW YORK — Billy Joel mourned the death of his friend and former bandmate, drummer Jon Small, on Monday. He was in his late 70s. “RIP Jon Small,” Joel posted
How Michael Carter-Williams Can Help Syracuse Basketball Program
The former SU guard has a new opportunity.
Pittsburgh entrepreneur donates storage systems to Seton Hill business, technology school
The founder of a Pittsburgh-based digital storage solutions company donated $35,000 worth of equipment to Seton Hill’s cybersecurity and computer science programs. Gene Leyzarovich, former Jetstor CEO, founded the Bloomfield company more than 30 years ago while studying at the University of Pittsburgh and working night shifts at UPMC. The
UCF Graded Top-10 Performer in CFB Following Week One
After a 73-6 blowout fueled by Duke Watson’s explosive debut, the Knights carry elite Pro Football Focus grades into a high-stakes road test against Pittsburgh’s high-powered offense.
Group of bikini baristas win nearly $2M in legal battle
Former bikini baristas at five coffee stands in the Puget Sound region say they were paid below minimum wage and forced to turn over earnings to keep up with strict
Dunlap highlights high home heating oil prices in Maine
Dunlap, who faces former Republican Gov. Paul LePage on the Nov. 3 ballot, said Maine continues to be the state where more people rely on home heating oil than any other.
Father-Son Duo Launch A Talent Discovery And Entertainment Ecosystem For Independent Performers
Father-son duo launch a talent discovery and entertainment ecosystem for independent artists because likes alone don't pay the bills.
Ham: Kings Rejected LaVine-Young Swap
As the Sacramento Kings continue to rebuild, the front office has clearly put a focus on getting younger. Zach LaVine and Domantas Sabonis are two players to monitor as the season progresses to see if the team is looking to deal one of their former NBA All-Stars.
Missy Woods sentenced Tuesday
The former high-profile CBI analyst got a decade in prison on four counts A Jefferson County district court judge on Tuesday sentenced a disgraced former Colorado Bureau of Investigation DNA analyst to a decade in prison. Jefferson County District Judge Andrew Poland sentenced Yvonne “Missy” Woods to 10 years on the most serious felony charge, […]
Former Oregon Ducks Standouts Are Flourishing in the NFL
Multiple former Oregon Ducks stars are thriving in their NFL careers.
Scientists Are Still Trying To Understand How the Moon Formed
The Earth and the Moon have nearly identical isotopic compositions, and the Giant Impact Hypothesis strives to explain this. New research into the ancient impact shows how the temperature of both worlds, and how it affects the strength of the materials involved in the collision, shaped the outcome, including the isotopic compositions.
Kansas State Adds Former Temple CB Ben Osueke
Temple Owls cornerback Ben Osueke was granted an extra year of eligibility and has decided to play for the Kansas State Wildcats
Gov. Gavin Newsom's former chief of staff seeks to delay sentencing because of health issues
Dana Williamson, Newsom's onetime chief of staff, is seeking to delay her sentencing date for political corruption because of health issues, according to documents.
Former Nebraska men’s basketball guard goes pro in Hungary
Former Nebraska men’s basketball guard Jamarques Lawrence has signed with NKA Universitas Pecs, a first-division team in Hungary.
Tigers and Cubs: Week 1 vs. Clemson
Who were the top performers on Saturday night? Who’s performance left a little to be desired?
Former MSU Interim AD Jon Palumbo Heading to Kentucky
The Spartans’ leadership exodus continues as another top executive reunites with J Batt in Lexington, leaving East Lansing to navigate a shifting front office after months of transition.
Heat linked to reunion with struggling ex-Lakers point guard
An NBA writer believes the Miami Heat should consider bringing back a former Los Angeles Lakers backcourt contributor for a second stint.
WKRC-TV adding 3 p.m. newscast, Sunday politics show
Former WXIX-TV anchor Rebecca Smith also returns to TV as Local 12’s new health reporter, filling the vacancy from the death of Liz Bonis in April.
If You Invested $1000 In Sphere Entertainment Stock 5 Years Ago, You Would Have This Much Today
Sphere Entertainment (NYSE:SPHR) has outperformed the market over the past 5 years by 18.95% on an annualized basis producing an average annual return of 30.39%. Currently, Sphere Entertainment has a market
Sheff Utd sign experienced forward Ayew
Sheffield United sign former Crystal Palace and Leicester City forward Jordan Ayew on a deal until the end of the season.
Former Kane Realty COO launches AI-powered real estate consulting firm
Bonner Gaylord and David Shaner co-founded Grounded Intelligence to help Triangle commercial real estate firms implement AI tools for competitive advantage.
Deonte Banks' ex-coach: 'Everbody's gonna see' why Giants drafted him
Henry Baker, the former coach of New York Giants CB Deonte Banks, believes everyone is about to see why he was a first-round pick.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Sunderland 'deserved more' at Brentford
Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.
How Is Hilton Worldwide's Stock Performance Compared to Other Leisure and Entertainment Stocks?
Hilton Worldwide has outperformed the Leisure and Entertainment industry over the past year, and analysts are cautiously optimistic about the stock’s prospects.
When Peekskill’s Small Businesses Are Left Behind
Opinion > Peekskill Brewery's former owner says a $100,000 city grant proved worthless in trying to save the popular restaurant
New York City releases thousands of pages regarding 9/11 air quality concerns
The release follows a 28-part records request filed in 2023 that was repeatedly delayed under former Mayor Eric Adams.
Williams warns WRU on 'almost non-existent' student support
Former Wales and Lions wing Shane Williams says pathways support for schools and colleges from the Welsh Rugby Union (WRU) is 'almost non-existent'.
He lost $180K in retirement savings, now drives Uber and Lyft at 58
Bill Lewis, a former Wall Street broker, now drives for Uber and Lyft after losing his retirement savings in a failed franchise venture.
Former employees accuse Family Health Centers of San Diego of understaffing, retaliation
Former employees take issue with how much cash the health system is sitting on while they say clinics are understaffed. The network has netted $58 million to $80 million each year since 2020, its tax filings show.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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