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Mediterranean diet may boost mitochondrial signals linked to heart and brain health

A study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondria, ...

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Mar 23 • 7:40 PM EDT • Health • medicalxpress.com
Revolutionary Women: Lady Johnson, Angelica Schuyler and the Politics of Loyalty

State and territory commissions and other partners are hosting events across the nation to commemorate America's 250 anniversary in 2026.

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Mar 23 • 7:24 PM EDT • Politics • america250.org
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Why are the Virginia Cavaliers sports teams also called the Wahoos?

The term “Wahoos” or “Hoos” are almost exclusively used by Virginia students when referring to their athletes and fans.

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Mar 23 • 6:51 PM EDT • Sports • usatoday.com
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Political traffic signals: waiting for the light to change on the Hill

Congress faces a steep political battle over a $200 billion Iran war spending request, with Trump sending mixed signals on whether the funds are needed.

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Mar 23 • 6:15 PM EDT • Politics • foxnews.com
Former political rivals take on Trump’s push to nationalize voting

GOP lawyer Ben Ginsberg and former Obama White House counsel Bob Bauer aim to present a united front against the Trump administration’s efforts to oversee election administration

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Mar 23 • 6:03 PM EDT • Politics • politico.com
After patient deaths, Idaho budget committee approves restoring cut Medicaid mental health programs

The Idaho Legislature will consider restoring mental health programs the state cut to comply with the governor’s order for budget cuts.

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Mar 23 • 5:34 PM EDT • Health • idahocapitalsun.com
Democratic and Republican Party officials face internal backlash after primaries

Party officials have received calls to resign amid endorsements and campaign spending in national and state primary elections.

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Mar 23 • 5:12 PM EDT • Politics • newsobserver.com
Veterinary Science Certificate Program promotes early steps on career path

Rural communities face a growing shortage of veterinary professionals, creating challenges for pet owners and livestock producers alike.

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Mar 23 • 4:59 PM EDT • Science • agrilifetoday.tamu.edu
Henderson County launches crisis response program for behavioral health emergencies

In Henderson County, officials say a new program is already working to respond when someone is in crisis, often through a 911 call.

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Mar 23 • 4:53 PM EDT • Health • wlos.com
Scientists Connect “Time Crystals” to the Outside World in Groundbreaking Experiment

A newly demonstrated link between a time crystal and a mechanical system opens a door scientists once thought closed.

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Mar 23 • 4:46 PM EDT • Science • scitechdaily.com
Someone has publicly leaked an exploit kit that can hack millions of iPhones

Leaked "DarkSword" exploits published to GitHub allow hackers and cybercriminals to target iPhone users running old versions of iOS with spyware, according to cybersecurity researchers.

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Mar 23 • 4:42 PM EDT • Technology • techcrunch.com
'Sled head': Lawsuits against USA Bobsled/Skeleton allege brain injury

Three personal injury lawsuits have been filed on behalf of elite bobsledders who claim officials intentionally concealed evidence that the sport causes brain injuries.

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Mar 23 • 4:31 PM EDT • Sports • latimes.com
Oura Ring 5 leak reveals design tweaks and Deep Rose finish

The Oura Ring 5 has surfaced in a leak showing design tweaks and colour options. An FCC registration hints the device may launch in 2026.

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Mar 23 • 3:54 PM EDT • Technology • gadgetsandwearables.com
'They mean business:' Trump says Iran wants a deal as Iranian officials deny talks
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Mar 23 • 3:21 PM EDT • Business • yahoo.com
Exclusive: Kalshi to block athletes and politicians from trading on their markets

Prediction market Kalshi plans to block athletes, coaches and officials from betting on their sports and to block political candidates from trading on their campaigns, Axios has learned.

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Mar 23 • 2:57 PM EDT • Politics • axios.com
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NYC Health + Hospitals/Jacobi | North Central Bronx Brings Novel Minimally Invasive Vascular Surgery Procedures to the Bronx - NYC Health + Hospitals

NYC Health + Hospitals/Jacobi | North Central Bronx today announced it has begun offering two types of minimally invasive surgical procedures that were

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Mar 23 • 1:58 PM EDT • Health • nychealthandhospitals.org
Beyond The Hype: How AI Is Rewiring Fashion’s Art And Science

AI is recalibrating fashion from design to supply chain. Explore how leaders at Levi’s, ALO Yoga, and REVOLVE bridge data-driven precision with human-inspired creativity.

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Mar 23 • 1:52 PM EDT • Science • forbes.com
5 ChatGPT Prompts To Start Your Own Business From Scratch

Plenty of people want to work for themselves but never start. Use these ChatGPT prompts to go from idea to business owner today.

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Mar 23 • 1:00 PM EDT • Business • forbes.com
Californians may need to mail ballots early as Supreme Court signals support for new election day deadline

California counts mail-in ballots that arrive up to seven days after election day, but that option may be deemed illegal

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Mar 23 • 12:26 PM EDT • Politics • latimes.com
Voice of America Journalists Sue, Saying Trump Officials Interfered in Coverage

The journalists said in the complaint that the administration was trying to force them to be a “mouthpiece” and that one official demanded “loyalty” if reporters wanted to “keep their jobs.”

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Mar 23 • 12:15 PM EDT • Politics • nytimes.com
Caesars Entertainment (CZR) Valuation Check After Recent Share Price Recovery

Caesars Entertainment stock overview Caesars Entertainment (CZR) has been drawing attention after recent share price moves, including a gain over the past month. This has prompted investors to reassess how its current valuation lines up with recent financial results. See our latest analysis for Caesars Entertainment. Recent trading has been choppy, with a 26.05% 1 month share price return contrasting with a 4.87% decline in 1 year total shareholder return. This signals momentum building in...

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Mar 23 • 11:17 AM EDT • Entertainment • simplywall.st
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Purple Demonstration Reveals Critical Security Gaps and Invisible Threats in Standard Business WiFi

Manchester, LANCS, March 23, 2026 (GLOBE NEWSWIRE) -- Purple, the global leader in guest WiFi, has issued a call for heightened digital caution ...

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Mar 23 • 11:00 AM EDT • Business • markets.businessinsider.com
How Will Gravity on Mars Affect Humans? A New Study Reveals a Clue.

Maintaining muscle mass is key.

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Mar 23 • 10:00 AM EDT • Science • sciencealert.com
New ‘Crimson Desert’ Patch Fixes Storage, Combat, Controls, Bosses, Fast Travel

A new Crimson Desert patch has fixed many of the game's biggest issues not even a week after launch. They really transform the game.

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Mar 23 • 9:11 AM EDT • Technology • forbes.com
Jack Gibbens reflects on ‘bittersweet’ decision to leave Patriots

Gibbens signed a two-year deal with the Cardinals in free agency.

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Mar 23 • 9:00 AM EDT • Sports • sports.yahoo.com
Cycling, crystals and cutting-edge science: the secrets of Hodgkinson and Hunter Bell’s success

The training duo who oversaw famous medal success in Torun believe the best is yet to come for their athletes

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Mar 23 • 8:59 AM EDT • Science • theguardian.com
Sewing And Munro Continue Dominance In New Global Sports Alliance International Pickleball Tour With Two Golds In Vietnam

The third event of the new Global Sports Pickleball Alliance saw the tour head to Ho Chi Minh City over the weekend, where Jack Munro and Sofia Sewing both won two golds.

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Mar 23 • 8:48 AM EDT • Sports • forbes.com
Data Is at the Heart of What Public Health Does

Data is key to protecting the health and safety of a community, from identifying and tracking disease outbreaks to ensuring that water is safe to drink. Data is also vital to understanding where resources are most needed. This value is especially apparent to the officials charged with protecting public health, such as Dr. Janet Berreman, Kauai’s (Kauaʻi’s)* district health officer.

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Mar 23 • 8:00 AM EDT • Health • pew.org
Free sports physicals return for public school students in Flagler and Volusia counties

Thousands of middle and high school students in public schools across Volusia and Flagler counties can receive free sports physicals this spring as AdventHealth helps young athletes prepare safely for the upcoming season.

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Mar 23 • 8:00 AM EDT • Sports • adventhealth.com
‘President Trump is right’: The White House’s go-to line about Trump’s false claims

President Donald Trump’s White House spokespeople have a favorite two-step reply when reporters ask them to comment on one of Trump’s false claims.

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Mar 23 • 7:00 AM EDT • Politics • cnn.com
D-FW business datebook for week of March 22

Earnings from GameStop, Commercial Metals and Lantern Pharma are part of a busy week.

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Mar 23 • 7:00 AM EDT • Business • dallasnews.com
Banijay Entertainment Dials Up Global Scripted with Premium Series Mania Slate

Media and entertainment powerhouse, Banijay Entertainment, today unveils its premium scripted offering for Series Mania, showcasing a broad range of high-end drama from across its global portfolio. As the number one European studio in scripted, with more than 100 titles launching each year, the company continues to demonstrate its scale, creative strength, global reach and […]

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Mar 23 • 6:26 AM EDT • Entertainment • banijay.com
Why the BTS Comeback Concert Was a ‘Disaster’ for Some Businesses

The turnout for the K-pop titans’ show was much lower than projected by officials, hitting the bottom line of some restaurants. Shares in the group’s management company also fell.

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Mar 23 • 5:48 AM EDT • Business • nytimes.com
Ambani's Reliance Jio: businesses and investors of the IPO-bound firm

Indian billionaire Mukesh Ambani's Reliance Jio Platforms is gearing up to file papers seeking regulatory approvals for a Mumbai listing, in what is likely to be the biggest-ever stock offering in the country.

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Mar 23 • 5:39 AM EDT • Business • reuters.com
In California, a Republican Sheriff Seizes Ballots, Prompting Concerns

Riverside County Sheriff Chad Bianco, a candidate for governor, recently took possession of more than 650,000 ballots as part of a fraud probe. Election officials say his investigation is baseless.

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Mar 23 • 5:03 AM EDT • Politics • nytimes.com
Leeds 0-0 Brentford

Paul: Leeds played as if they are frightened of losing rather than trying to win. Chris: Good point in the end - they are a good side pushing for a European place and have good players. Hopefully in the final run-in we will see more of Daniel James, Wilfried Gnonto and Noah Okafor, especially in the home games, to create more goals and keep us in the Premier League.

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Mar 23 • 4:22 AM EDT • Sports • sports.yahoo.com
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Dr Liz O'Riordan: Women's health must be taken more seriously

Dr Liz O'Riordan says it is important women seek help from professionals not "Google and Chat GPT".

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Mar 23 • 2:46 AM EDT • Health • bbc.com
Incredible offer signals Liverpool are all-in on Rio Ngumoha

An incredible offer of a player signals a real intent from Liverpool to go all-in on teenager Rio Ngumoha.Are Liverpool about to go all-in on Rio Ngumoha? They’ve been reluctant to do so this season...

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Mar 23 • 2:35 AM EDT • Sports • sports.yahoo.com
AI Swarm Attacks Are Coming, Is Your Business Ready?

Leaders need a new cybersecurity playbook for the agentic era, with stronger governance, faster response systems, workforce awareness, and up-to-date security frameworks.

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Mar 23 • 2:27 AM EDT • Business • forbes.com
Power Play Primed – Hurricanes 5, Penguins 1

The Carolina Hurricanes scored three power play goals and dominated the Pittsburgh Penguins, 5-1 on Sunday afternoon in the Steel City. The Canes controlled the puck most of the game and were holding the Pens to a paltry 12 shots on goal until the Pens finally found some offense with five minutes and change to […]

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Mar 23 • 12:35 AM EDT • Sports • sports.yahoo.com
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Costco Expands Member Offerings With Fertility Care And In Store Events

Costco Wholesale has partnered with Sesame and IVI RMA North America to offer U.S. members access to advanced fertility care with exclusive pricing and coordinated services. The retailer is also rolling out a national outdoor cooking roadshow in warehouses, featuring multiple brands and on site experiences for members. These moves extend Costco’s reach further into healthcare services and experiential retail beyond its traditional bulk merchandise model. For investors tracking...

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Mar 23 • 12:23 AM EDT • Health • finance.yahoo.com
2026 Best Business Schools | How Alumni Rate Their Undergraduate Business Degrees

Alumni rate their undergraduate business programs in Poets&Quants’ 2026 ranking, evaluating academic experience, career preparation, advising, and how well their degrees support long-term career goals.

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Mar 23 • 12:00 AM EDT • Business • poetsandquantsforundergrads.com
California Politics 360 Full Episode | Sexual abuse allegations against César Chávez

Civil rights leader Dolores Huerta broke her silence, saying she was also sexually abused by Chávez. It led to the birth of two children, a secret she kept for 60 years.

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Mar 22 • 11:25 PM EDT • Politics • kcra.com
UTA College of Business to connect students, professionals with networking, elevator pitch event

Students, business professionals and recruiters will mingle from 6 to 8 p.m. Monday at the UTA Center for Entrepreneurship and Technology Development.

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Mar 22 • 11:00 PM EDT • Business • theshorthorn.com
CBS Sports and TNT Sports Announce Tip Times and Commentator Teams for Regional Semifinals on Thursday, March 26, and Friday, March 27
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Mar 22 • 10:41 PM EDT • Sports • ncaa.com
A DNA test ruled him out. He was convicted of murder anyway.

Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.

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Mar 22 • 9:57 PM EDT • Science • bostonglobe.com
B.C. recruits 400 healthcare workers, most from Washington and Oregon

A successful targeted campaign recruited more than 400 U.S.-trained healthcare professionals to British Columbia, many of whom are from Oregon and Washington.

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Mar 22 • 8:01 PM EDT • Health • katu.com
A promising fatty liver treatment may raise cancer risk

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.

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Mar 22 • 8:00 PM EDT • Science • sciencedaily.com
Analyst reveals high expectations for 49ers after free agency spree

Could the 49ers really challenge in 2026?

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Mar 22 • 7:20 PM EDT • Sports • sports.yahoo.com
Sunday Sports: Sackets hoops in the state finals, plus updates on SU sports

Here’s a recap of your North Country sports this Sunday.

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Mar 22 • 6:20 PM EDT • Sports • wwnytv.com
This Couple Turned A Facebook Marketplace Side Hustle Into A Seven-Figure Business

When Harrison Gordon and Paige Sandher couldn't find a modular custom sofa that was also affordable, they designed their own. They built a fast-growing business around their idea.

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Mar 22 • 6:19 PM EDT • Business • forbes.com
Man Born with ‘Butterfly Syndrome’ Is Fighting for Change for ‘the Worst Disease You’ve Never Heard of’ (Exclusive)

Ohio resident Shane DiGiovanna, who has the rare disorder epidermolysis bullosa (EB), is advocating for legislation to help cover costly medical bandages for patients with the disease, which is also known as ‘butterfly syndrome.’

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Mar 22 • 6:00 PM EDT • Health • people.com
The FBI Just Issued A Warning About A Hidden Threat In Your Home Wi-Fi Network

The FBI is warning that criminals may hijack your home Wi-Fi through residential proxies, using your IP address to hide illegal online activity.

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Mar 22 • 4:45 PM EDT • Technology • slashgear.com
Full 7-round Arizona Cardinals mock draft simulation

We have a new 7-round mock draft for the Arizona Cardinals.

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Mar 22 • 3:51 PM EDT • Sports • sports.yahoo.com
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Slovenia liberals take narrow election lead over conservatives: exit poll

Exits polls suggest Prime Minister Robert Golob has blocked a fourth term for right-winger Janez Janša

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Mar 22 • 3:36 PM EDT • Politics • euractiv.com
Nevada Wins Temporary Ban on Sports Betting on Kalshi

The prediction-market platform must obtain state gambling licenses and prohibit users under 21 to offer such contracts, a state court said.

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Mar 22 • 2:40 PM EDT • Sports • wsj.com
City of Paducah Finance Department to host informational workshop on Business License Renewals

In case you missed it, the City of Paducah Finance Department will host an informational workshop on Business License Renewals for local business owners at the McCracken County Library tomorrow,

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Mar 22 • 2:34 PM EDT • Business • wpsdlocal6.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
United Airlines Just Issued a Playbook for Any Business Staggered by Skyrocketing Costs

In a letter to employees, CEO Scott Kirby delivered a master class on boosting morale as he deals with the impact of surging jet fuel prices.

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Mar 22 • 1:52 PM EDT • Business • inc.com
4 myths about backyard birds, debunked

Birds also won't abandon a baby if you touch it.

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Mar 22 • 1:00 PM EDT • Science • popsci.com
What’s happening in Vegas arts entertainment this spring

Festivals, concerts, sporting events and more: Make plans with our entertainment calendar.

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Mar 22 • 12:41 PM EDT • Entertainment • neon.reviewjournal.com
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Top 5 states with the highest number of safe hospitals, according to new report
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Mar 22 • 12:27 PM EDT • Health • nypost.com
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Apple’s busy March continues with three notable arrivals this week

Apple has had a jam-packed March so far after launching seven new products and surprisingly announcing an eighth. Looking ahead,...

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Mar 22 • 11:47 AM EDT • Technology • 9to5mac.com
California sheriff seizes 650,000 ballots in defiance of state officials over election count dispute

Riverside County Sheriff Chad Bianco seized over 650,000 ballots to probe alleged excess votes in California's Proposition 50 special election.

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Mar 22 • 10:48 AM EDT • Politics • foxnews.com
VoidStealer malware steals Chrome master key via debugger trick

An information stealer called VoidStealer uses a new approach to bypass Chrome's Application-Bound Encryption (ABE) and extract the master key for decrypting sensitive data stored in the browser.

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Mar 22 • 10:32 AM EDT • Technology • bleepingcomputer.com
It's not just vaccines — parents are refusing other routine preventive care for newborns

Doctors are alarmed that skepticism fueled by rising anti-science sentiment is increasingly reaching beyond vaccines to other proven, routine, preventive care for babies.

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Mar 22 • 9:26 AM EDT • Health • boston.com
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Inside a rare lab that's blazing a bold trail as it hunts for new drugs

A scientist from Zambia who loves — LOVES! — chemistry runs a lab in South Africa that is being hailed for "extraordinary" work.

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Mar 22 • 9:25 AM EDT • Technology • npr.org
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Inside a rare lab that's blazing a bold trail as it hunts for new drugs

A scientist from Zambia who loves — LOVES! — chemistry runs a lab in South Africa that is being hailed for "extraordinary" work.

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Mar 22 • 9:25 AM EDT • Health • npr.org
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Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo

One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening

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Mar 22 • 8:30 AM EDT • Entertainment • pasadenanow.com
Scientists discover surprising brain trigger behind high blood pressure

Scientists have uncovered a surprising brain-based trigger for high blood pressure, tracing it to a small region in the brainstem that normally controls breathing. This area, which kicks in during forceful exhalations like coughing, laughing, or exercise, also appears to activate nerves that tighten blood vessels—raising blood pressure. When researchers switched off this region in experiments, blood pressure dropped back to normal, suggesting it plays a direct role in hypertension.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
This floating time crystal breaks Newton’s third law of motion

Scientists have created a new kind of time crystal using sound waves to levitate tiny beads in mid-air. These particles interact in a one-sided, unbalanced way, breaking the usual rules of motion and creating a steady, repeating rhythm. The system is surprisingly simple yet reveals complex physics with big implications. It could help advance quantum computing and deepen our understanding of biological timing systems.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Scientists twisted a mysterious superconductor and got a shocking result

A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Why mosquitoes always find you and how they decide to attack

Scientists have finally cracked how mosquitoes decide where to fly—and it’s not by following each other. Instead, each insect independently reacts to visual cues and carbon dioxide, zeroing in on humans when both signals align. Dark colors and CO2 together create the strongest attraction, triggering swarming and biting behavior. This insight could reshape how we design traps and prevent mosquito-borne diseases.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
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‘We can create hype’: H&M’s UK boss on its commitment to the high street

As the chain marks 50th anniversary in Britain, Karen O’Rourke explains what makes it stand out against cut-price rivals

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Mar 22 • 4:00 AM EDT • Business • theguardian.com
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‘The best course I've taught’: Duquesne business students, faculty volunteer to help with taxes

After hearing in 2018 about a way to help low- to middle-income individuals and families with preparing their tax returns, Amy Yurko, now an associate...

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Mar 22 • 4:00 AM EDT • Business • post-gazette.com
Mt. Vernon withstands 'nightmare' scenario, punches ticket to state finals

Luke Ertel was on the bench with four fouls as Mt. Vernon's lead slipped. He returned to help Marauders punch ticket to state.

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Mar 21 • 11:41 PM EDT • Sports • sports.yahoo.com
Arizona Cardinals GM perhaps gave hint about Michael Wilson's future

We compare what Monti Ossenfort said this offseason about Michael Wilson with what he said about Trey McBride last year.

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Mar 21 • 9:34 PM EDT • Sports • sports.yahoo.com
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Deals: Galaxy S26 series gets its first price drop, the Pixel 10 series drops even further

Meanwhile, the 2025 MacBook Airs are getting cheaper too - not quite as cheap as the Neo, but they are an important alternative for those who need more RAM.

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Mar 21 • 9:31 PM EDT • Technology • gsmarena.com
Clemson's Mia Moore and USC's Kara Dunn renew rivalry in overtime thriller

Moore and Dunn both grew up near Atlanta, and first matched up in middle school. They also played AAU together in high school.

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Mar 21 • 8:31 PM EDT • Sports • usatoday.com
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Kings fall 4-1 to Sabres amidst playoff push

The Los Angeles Kings fall short to the Buffalo Sabres in a 4-1 loss Saturday at Crypto.com Arena. Artemi Panarin would score the Kings' lonesome goal, but it was no match for Buffalo's four goals by four different skaters. The Kings stand in the third place Wild Card spot at 28-25-16 and 72 points.

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Mar 21 • 8:25 PM EDT • Sports • sports.yahoo.com
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Brooks Nader, 29, Reveals She Had Liposuction ‘Years Ago’ and Regrets It: ‘I Just Didn’t Need It’ (Exclusive)

The model and reality star tells PEOPLE that she experienced unwanted side effects from the procedure

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Mar 21 • 8:14 PM EDT • Technology • uk.news.yahoo.com
Washington Football Hires Utah State Analyst as Special Teams Analyst

Washington will once again have two coaches working on specials teams in 2026 after added a rising analyst to work alongside Chris Petrilli.

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Mar 21 • 8:00 PM EDT • Sports • sports.yahoo.com
Webb Telescope spots “impossible” atmosphere on ancient super Earth

Astronomers have uncovered surprising evidence of a thick atmosphere surrounding TOI-561 b, a scorching, fast-orbiting rocky planet once thought too extreme to hold onto any gas. Using NASA’s James Webb Space Telescope, researchers found the planet is far cooler than expected for a bare rock, hinting at a heat-distributing atmosphere above a churning magma ocean. This strange world—where a year lasts just over 10 hours and one side is locked in eternal daylight—may even be rich in volatile materials, behaving like a “wet lava ball.”

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
Mapping a career in electron microscopy

Nature Reviews Chemistry - Ahead of his 60th birthday, Paul A. Midgley, Professor of Materials Science at the University of Cambridge, discussed his life in science.

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Mar 21 • 8:00 PM EDT • Science • nature.com
LeBron James breaks record for most NBA games played

LeBron James broke the NBA record for most regular-season games played on Saturday, taking the court for his 1,612th when the Los Angeles Lakers tipped off against the Orlando Magic.James, playing his unprecedented 23rd season, already holds a host of NBA records, including points scored, field goals made and field goals attempted and the longest streak of regular-season games with at least 10 points scored -- 1,297 -- in history.

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Mar 21 • 7:22 PM EDT • Sports • sports.yahoo.com
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Top 5 states with the highest number of safest hospitals, according to new report

Healthgrades named 438 hospitals across 40 states for its 2026 Patient Safety Excellence Award, with Texas and Florida among the top-performing states.

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Mar 21 • 4:25 PM EDT • Health • foxnews.com
Trump Is Finally Eyeing an Exit From Iran. But Will He Take It?

President Trump says he is considering “winding down” operations in Iran. But many of his original war goals remain unaccomplished.

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Mar 21 • 3:29 PM EDT • Politics • nytimes.com
Roberson's Sam Maki leads Week 4 girls spring sports top performers

Roberson soccer's Sam Maki scored five goals to lead the list of Week 4 WNC high school spring sports girls top performers.

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Mar 21 • 2:16 PM EDT • Sports • citizen-times.com
County seeks public input on behavioral health services plan

San Diego County health officials were seeking public input Saturday on how best to provide behavioral health services to county residents.

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Mar 21 • 2:04 PM EDT • Health • timesofsandiego.com
Scientists Recruit Undergrad to Step Into Room Filled With Ravenous Mosquitoes for “Full-Body Massacre”

Researchers at Georgia Tech used undergraduate student Chris Zuo as bait in trials to study mosquito flight behaviors.

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Mar 21 • 2:00 PM EDT • Science • futurism.com
Mojang Reveals Chaos Cubed Update Coming to Minecraft Later This Year With Tiny Takeover Release Date Set for Next Week

Mojang has unveiled more information about updates coming to Minecraft in 2026, including the release date for Tiny Takeover and a sneak peek at the Chaos Cubed game drop.

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Mar 21 • 1:24 PM EDT • Technology • ign.com
UFC Fight Night odds, lines, predictions, time: Evloev vs. Murphy picks from proven MMA expert

Expert Kyle Marley reveals his UFC Fight Night best bets for the March 21 London card on Paramount+

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Mar 21 • 1:21 PM EDT • Sports • cbssports.com
Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout

Spanberger will mull theirs and former Gov. Glenn Youngkin’s budget proposals ahead of a reconvened session on April 23.

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Mar 21 • 1:10 PM EDT • Health • wtop.com
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ENTERTAINMENT: Walton Arts Center’s lineup features 5 Broadway shows

Season subscribers will also “be the first in line to guarantee your seats for the Northwest Arkansas debut of ‘Wicked,’” already on the schedule for the 2027-’28 season.

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Mar 21 • 1:00 PM EDT • Entertainment • arkansasonline.com
Physicists created an electron 'catapult' that moves particles at 'extraordinary' speed

Using a new method, physicists found a way to 'catapult' electrons across solar materials in quadrillionths of a second.

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Mar 21 • 11:00 AM EDT • Science • livescience.com
Tee-time thaw

Remnants of winter linger as golfers tee off during opening day at Candia Woods Golf Links in Candia on Friday which also was the first day of spring.

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Mar 21 • 10:35 AM EDT • Sports • unionleader.com
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Doctors are in: Stuffed animals get health checks at zoo's Teddy Bear Care Fair

Toddlers Eliza and Olivia Altman watched attentively as Toledo Zoo & Aquarium volunteers performed “surgery” on their nearly decapitated stuffed animals ...

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Mar 21 • 10:26 AM EDT • Health • toledoblade.com
Cade Cavalli Looks to End Nationals Spring Training Losing Streak
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Mar 21 • 9:14 AM EDT • Sports • sports.yahoo.com
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UFC Fight Night odds, lines, predictions, time: Evloev vs. Murphy picks from proven MMA expert

Expert Kyle Marley reveals his UFC Fight Night best bets for the March 21 London card on Paramount+

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Mar 21 • 8:46 AM EDT • Sports • cbssports.com
Ancient DNA reveals a farming shift that pushed a society to the brink

A new study reveals that farming in Argentina’s Uspallata Valley was adopted by local hunter-gatherers rather than introduced by outside populations. Centuries later, a stressed group of maize-heavy farmers migrated into the region, facing climate instability, disease, and declining numbers. Despite these pressures, there’s no sign of violence—instead, families stayed connected across generations, using kinship networks to survive. The research shows how cooperation, not conflict, helped communities navigate crisis.

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Mar 21 • 8:00 AM EDT • Science • sciencedaily.com