SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " Nev " 2,665 found 🔀 AI-powered Shuffle
How live selling is helping one entrepreneur grow his business
Running a business has been a "roller coaster of a ride," said Scott Wool, who nearly went bankrupt in 2013. Today, he's growing like never before.
Yankees’ Netflix debut is latest example of sports’ complicated TV landscape
Fans have never had more access to live sports on TV. But it comes with costs, like navigating a maze of networks and new subscription fees.
Kentucky basketball assembled a $22 million roster. The results never matched the price.
Kentucky is making a bold move that could signal where the future of college sports is headed.
Amazon drops prices on Apple bestsellers — Shop AirPods, MacBooks, and more at the Spring Sale
If you shop with us, you'll never pay full price.
Women’s Month Weekly: There’s never been a better time to be a girl in sports
With the influx of audiences now drawn to women's sports, younger girls are growing up in an environment that celebrates them.
Teleportation is no longer just science fiction—at the quantum level
We may never beam ourselves off the planet. But quantum teleportation is poised to bring about a new era of computing—and revolutionize our understanding of the subatomic world.
Nevada university launches massive life science incubator in Las Vegas
Roseman University of Health Sciences announced the launch of Roseman Bioventures, a 120,000 square-foot facility located on its Summerlin campus.
AccuWeather is now available inside ChatGPT
Never again will you have to exit your AI app to check the forecast.
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
The 10 Best Beatles Documentaries, Ranked
From rare footage to rooftop concerts, these Beatles documentaries reveal the Fab Four like never before—see which ones made the cut.
Did you remember to pack the antimatter? CERN takes antiprotons for a short drive
Scientists in Geneva took some antiprotons out for a spin — a very delicate one — in a truck, in a never-tried-before test drive that has been deemed a success.
Lawmakers weighed Wyoming Health Department budget cuts. They never came.
by Maggie Mullen, WyoFile After the Wyoming Freedom Caucus told voters last year it aimed to “DOGE” the state’s next two-year budget by
Christine Ebersole, Cheyenne Jackson and a Sunday night in New Orleans I'll never forget
The invitation said "Un Salon Moderne à la Nouvelle-Orléans." That was about all anyone knew. Jan Risher was in New Orleans Sunday night for an event that nobody saw coming — and what it left her thinking about.
On the road with antiprotons: CERN runs delicate test on transporting ultrasensitive antimatter
Scientists at CERN plan to take some antiprotons out for a spin in a never-tried-before test drive.
Scientists take antimatter on first road trip as they study how to transport ultra-sensitive cargo
Scientists at CERN are taking some antiprotons out for a spin in a never-tried-before test drive.
On the Road With Antiprotons: CERN Runs Delicate Test on Transporting Ultrasensitive Antimatter
GENEVA (AP) — Scientists in Geneva are taking some antiprotons out for a spin — a very delicate one — in a truck, in a never-tried-before test drive. If this so-called antimatter comes into contact with actual matter — even for a fraction of an instant — it will be annihilated in a quick flash of ...
Neal Stephenson, who coined the term ‘metaverse’, says head-mounted VR hardware will never happen
: ‘People don’t like wearing things on their faces and don’t trust those who do’
Grizzlies never threaten Hawks as Memphis falls to Atlanta
The tank was strong for the Grizzlies in Atlanta.1-11 in 12 games. PHEW.
Jacobs Entertainment gets permits for sports fields, now under construction
2 News Nevada has gotten a look at new youth sports fields that are under construction in downtown Reno.
5 ChatGPT Prompts To Start Your Own Business From Scratch
Plenty of people want to work for themselves but never start. Use these ChatGPT prompts to go from idea to business owner today.
Feature: Where The Heck Do You Start If You've Never Played Resident Evil?
Enter the world of survival horror
A new twist on matter? Strange 'Half-Mӧbius' molecule has rare properties chemists have never seen before
Chemists created a strange 'half-Mӧbius' molecule, where electrons twist freely out of place to make a continuously looping surface.
Cleanup underway after pick-up truck crashed into science surplus store in Geneva
Man Born with ‘Butterfly Syndrome’ Is Fighting for Change for ‘the Worst Disease You’ve Never Heard of’ (Exclusive)
Ohio resident Shane DiGiovanna, who has the rare disorder epidermolysis bullosa (EB), is advocating for legislation to help cover costly medical bandages for patients with the disease, which is also known as ‘butterfly syndrome.’
iRacing on Vision Pro bringing 'immersion and fidelity never before seen in sim racing'
iRacing on Apple Vision Pro will bring a “level of immersion and fidelity never before seen in sim racing,” says...
Nevada Wins Temporary Ban on Sports Betting on Kalshi
The prediction-market platform must obtain state gambling licenses and prohibit users under 21 to offer such contracts, a state court said.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Politics Now: March 22, 2026
This week on Politics Now with host John Langeler: Nevada is trying to lessen its reliance on fuel from California. We talk with the vice-chair of the committee tasked with determining how to do th…
A tribute to Scott Ostler, columnist, colleague, friend and sports wit
In Bruce Jenkins’ experience, there was never a teammate quite like fellow San Francisco Chronicle columnist Scott Ostler, who retired last week.
4 Things You Never Knew Your PS5 Could Do
The PlayStation 5 lets users create custom button mapping, play from a PC and Mac, use motion control to aim, and amplify sounds with headphones.
Andrej Karpathy says he uses an AI agent to control his pool
Andrej Karpathy said an AI agent named Dobby texts him whenever he gets a Fedex package and helps him control his spa.
Health Literacy as a Modifiable Clinical Risk Factor: Operationalizing an Underrecognized Determinant of Outcomes
Health literacy has been considered a social determinant of health and has never been extensively incorporated in the general practice of clinical care. Systematic reviews and cohort studies sho...
Cowboys land top pass rusher in new mock draft
It feels inevitable that Dallas will take a pass rusher in the first round.
Ex-Dolphins WR Jaylen Waddle on trade: 'It’s part of the business'
"You never know for sure and what could happen," Jaylen Waddle said of NFL trades. "It’s part of the business."
Combating youth suicide tilts increasingly toward early intervention
A suicidal child or teenager may never talk of taking their life. Parents, peers and teachers might not even know they’re living with mental illness. Despite younger generations showing greater openness to discussing mental health struggles, fears of punishment or social exclusion remain, experts say. Even at medical appointments, minors
March Madness conference records: How Big Ten, SEC, Big 12 and other fared in Round 1
Conference loyalty has never been more of a talking point than it is in the NCAA now. Here's a look at how each conference fared in the first round.
The biggest medieval march in English history never actually happened
A famous detail in the Battle of Hastings is based on a major misunderstanding.
Opinion | Why the Trump FCC Cares About Your Sports Viewing
Its irrepressible chairman never runs out of ways to advance the president’s political interests.
Overcoming Self-Doubt When Launching Your Own Business
Building a company will always test your confidence. Some days will stretch it; others will rattle it to the core. Self-doubt in those moments is not a sign you’re not cut out to lead. It’s what happens when you’re creating something new, the stakes are real, and you care deeply about the outcome. The founders who lead well over the long run aren’t the ones who never doubt themselves. They are the ones who have learned to work with it.
America started a war. The economic pain will be borne by countries that never asked for it
The war in Iran has delivered what economists call a “black swan” event — an unforeseen shock so destructive, no one is immune to it.
14 silly, never-before-seen images from the Comedy Wildlife Photography Awards
Nature, you're hilarious.
CEO of $5B startup took 'shortcuts' to grow business—until 'alarm bells' went off: Without change, we wouldn't 'have a company'
Faire risked never turning its sky-high valuation into sustainable business — until a moment that caused CEO Max Rhodes to change his approach, he says.
German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
Google Maps could soon get a long-overdue upgrade that replaces WhatsApp and Google Messages for location ...
Sharing your location has never felt this simple and fast.
Venezuela's yanqui-beating baseball triumph evokes politics — and yet something else more vital
COMMENTARY Venezuela's first World Baseball Classic title win, against the U.S. in Miami, inevitably packed political symbolism — but it radiated a more important reminder of the country's character.
Nevada defeats Murray State 89-75 in NIT
RENO, Nev. (AP) Vaughn Weems had 23 points in Nevada's 89-75 win over Murray State on Wednesday in the NIT.
Integrating health equity into energy transitions and climate governance
Nature Medicine - The health benefits of clean energy transitions are unevenly distributed, even when emissions targets are met. A health-centered global governance framework is urgently needed to...
Scientists recreated a dinosaur nest to solve a 70-million-year-old mystery
Scientists recreated a life-size oviraptor nest to understand how these dinosaurs hatched their eggs. Their experiments showed the parent likely couldn’t heat all the eggs directly, meaning sunlight played a key role. This uneven heating could cause eggs in the same nest to hatch at different times. The results suggest oviraptors used a hybrid incubation method unlike modern birds.
Tom Brady 'unlikely' to play flag football at 2028 Olympics but leaves door open: 'Never say never'
Brady did not entirely rule out an appearance on the inaugural Team USA roster
Kalshi faces criminal charges in Arizona for running an illegal gambling business
In the Wild West days of illegal gambling, a shootout was inevitable.
The Paleo Diet Never Existed. Scientists Found What Early Humans Were Really Eating.
Humans are actually limited in how much protein they can metabolize for energy, meaning early humans really needed a more well-rounded diet to survive.
Montana senator pulls a fast one to boost preferred successor
Incumbent Steve Daines timed his retirement to all but guarantee his preferred successor will replace him. Never mind what voters, or other hopefuls, had in mind.
Smack talk takes center stage at this open mic for amateur wrestlers
NAW or Never: Smack Talk Open Mic is a place where wrestlers work out their character muscles, polish their submission holds and perfect their trash-talking chops.
Why Denver should care about conservation easements — even if you’ve never set foot on a ranch
By Jason Swan I live in Denver. I drink tap water from my kitchen sink, hike close to home when I can, worry about wildfire smoke every summer, and try, like many families, to keep up with the rising cost of living. I don’t own land. I don’t ranch. I don’t farm. And yet one […]
Legislation shifts too big a burden onto family court
By Judi Atwood I know what a family-court snafu looks like because I lived one. In military slang, a snafu is a breakdown so confused and badly managed the people trapped inside it pay the price. In my own case, the court adopted and preserved findings about my conduct even though I was never served, […]
The scientist who warned that profit, not science, decides which drugs reach patients
In a Genomic Press Interview published in Brain Medicine, Dr. Gabriella Gobbi, Professor of Psychiatry at McGill University, Canada Research Chair (Tier 1) in Therapeutics for Mental Health, and President-Elect of the Collegium Internationale of Neuropsychopharmacology (CINP), delivers a pointed warning: the greatest threat to drug discovery is not scientific failure but a financing system that abandons effective, affordable treatments whenever they cannot promise sufficient returns to investors. Across a career that began in central Italy and moved through Sardinia and Montreal, Dr. Gobbi has generated landmark research linking adolescent cannabis exposure to depression, identified novel melatonin receptor mechanisms in sleep and pain, and launched psychedelic neuroscience before it became fashionable. The interview reveals a scientist whose best questions have always begun at the bedside, and whose most urgent fears concern the structures that stand between discovery and patients.
Hilary Duff defends her mother Susan after Frankie Muniz called her a 'super intense’ stage mom during the 'Lizzie McGuire' days
Hilary Duff defends mother Susan after Frankie Muniz labeled her ‘super intense’ stage mom: ‘I was never pushed into acting.'
'A moment he'll never forget'
Ex-England striker Wayne Rooney has praised Max Dowman's impact after the Arsenal winger became the Premier League's youngest goalscorer - but wonders if the 16-year-old might have to focus on his GCSEs for the rest of the season. The teenager scored in a 2-0 win over Everton that helped the Gunners move nine points clear at the top of the Premier League. Rooney was once the Premier League's youngest scorer when he netted for Everton against Arsenal in 2002.
Women in Politics: A Persistent Glass Ceiling
Women are presidents or heads of government in only 28 of the world’s 195 countries, and 101 states have never had a female leader.
Extreme Ocean Pressure Is Feeding Deep-Sea Life in a Way Scientists Never Expected
High pressure in the deep ocean may squeeze nutrients from sinking “marine snow,” feeding deep-sea microbes and altering how carbon moves through the ocean.
The fast rise and epic fall of Clubhouse
On Version History: the story of an audio social revolution that never quite took off
You’ll never see us: The Denver family business preserving neon
For more than 40 years, a little shop in Denver has worked to keep neon here “forever.”
Marjorie Taylor Greene Was Never Fringe
The Georgia congresswoman is out of office. Her conspiracies continue to define her party.
Fund-raising Email Features Trump at Ritual for Soldiers Killed in Iran War
The email from the group Never Surrender seeks donations for President Trump from those who want access to “private national security briefings” from him.
Burt Jones was the inevitable Republican nominee for Georgia governor. Then Rick Jackson showed up
Burt Jones is Georgia’s lieutenant governor and he seemed to have a clear path to be the Republican nominee for governor this year with President Donald Trump’s endorsement, But then health care tycoon Rick Jackson got into the race in February and he’s already spent more than $30 million of his own money on television campaign ads
Burt Jones was the inevitable Republican nominee for Georgia governor. Then Rick Jackson showed up
Burt Jones is Georgia's lieutenant governor and he seemed to have a clear path to be the Republican nominee for governor this year with President Donald Trump's endorsement, But then health care tycoon Rick Jackson got into the race in February and he's already spent more than $30 million of his own money on television campaign ads.
Millions of Americans are skipping meals or cutting back on utilities to afford health care
“I never thought I’d be living like this,” said Sheila Nesbit, a retired librarian.
The $40 Billion Game of Youth Sports Has Only One Winner: Dick’s Sporting Goods
Parents have never spent more time and money on youth sports—or at this sports juggernaut..
Willie Robertson says he ‘never would have dreamed’ of joining family business in his 20s
The Duck Commander CEO reflects on nearly taking a different path and explains why, on “Duck Dynasty: The Revival,” he now encourages his children to pursue what they love.
Empire of Slop: Mass Entertainment Has Never Been Worse
Our technical capacity to render fantasy has never been greater. Mass entertainment has never been worse.
Apple Clears Out M5 MacBook Pro at an All-Time Low After Its New Laptop Launch, Featuring 14.2-inch Liquid Retina XDR Display
Upgrading to a powerful MacBook has never been easier.
Google Maps Adds Gemini AI-Powered 'Ask Maps' Feature and 3D Immersive Navigation
Google today added Gemini AI to Google Maps, enabling a new Ask Maps feature. Gemini in maps can answer complex, real-world questions that Google says "a map could never answer before".
New Iranian leader Khamenei vows 'never ending' revenge in first public statement
Iranian Supreme Leader Mojtaba Khamenei provided a statement for the first time since U.S.-Israeli strikes killed his father, Ayatollah Ali Khamenei.
Business Property Statement Deadline Quickly Approaching
Nevada County Assessor Rolf Kleinhans is reminding business owners that time is running out to file their Business Property Statement with the Assessor’s Office. The annual filing period runs from January 1 through April 1. To streamline the process, businesses can file their Business Property Statements (BOE 571-L) electronically. The statement is due on April […]
Predictions, Odds, Analysis! UFC Vegas 114, X-Factor
This weekend (Sat., March 14, 2026), Ultimate Fighting Championship (UFC) will return home to the Meta APEX in Las Vegas Nevada, for UFC Vegas 114. Maybe this is the event that really turns things around and ends the UFC’s miserable 2026 start, but … probably not. Don’t get me wrong, Josh Emmett vs. Kevin Vallejos […]
Watching Ukraine, NATO artillery crews learn to work drones in Arctic
NATO commanders told Business Insider that drones are useful but could never fully replace the reliability of old-fashioned artillery.
Hundreds of GPs tell BBC they have never refused a sick note over mental health concerns
The number of fit notes issued has been rising, with more than 11.2m approved in England last year.
Jill Biden's new memoir will offer her perspective on the decision to end Biden's 2024 reelection bid
A political spouse for nearly 50 years, Jill Biden said she has never publicly discussed her feelings about the three-week stretch when her husband ended his political career, instead saving her thoughts for the pages of her soon-to-be-released memoir.
Exclusive | Trump Ordered Justice Department Reversal on Law Firm Sanctions
‘I never signed off on that,’ the president told aides in the Oval Office, expressing displeasure with Justice Department leadership.
Motorola Razr 2026 certification surfaces with familiar design and new specs
Motorola has clearly been busy, from the upcoming Razr Fold to the FIFA edition Razr 2025. That never meant the...
Politics of power: NV Energy’s demand charge could sway race for governor, says expert
Community and energy industry advocates are calling on Republican Gov. Joe Lombardo to halt NV Energy’s controversial peak demand charge that is expected to increase some bills by $20 a month and is set to take effect in Southern Nevada on April 1. Lombardo’s reaction, as well as his opponents’, to calls to intervene could […]
Ballad Health leader to challenge state Rep. David Hawk in GOP primary
GREENEVILLE, Tenn. (WJHL) — A Ballad Health leader is looking to unseat longtime Greene County state Rep. David Hawk in the August Republican primary. Tammy Albright submitted a petition to run for…
No contest: The uneven playing field of high school sports
Public school athletic programs across Miami-Dade are struggling to keep pace with well-funded private school rivals, as shrinking enrollment, limited budgets and transfer rules reshape the high school sports landscape.
Billionaire Brin Now Bets on a Republican to Govern California
Sergey Brin is spending millions of dollars to influence California politics, bankrolling two rival gubernatorial candidates and other political efforts, just months after ditching the state for Nevada.
Apple creates adorable little Finder guy to promote its adorable little Mac
Apple is pitching the MacBook Neo at people who’ve never owned a Mac before, and it’s reaching out to them...
Out of prison, GOP strategist Tony Dane is back in Nevada politics
After resolving a legal case in Nevada and serving years in a Virginia prison, the operative is working for a congressional candidate.
JFRD didn’t inspect a halfway house for 59 years. Inspectors then found costly issues that could put it out of business
A Jacksonville nonprofit that has helped people recover from drug and alcohol addiction for nearly six decades is now facing costly safety upgrades after a recent fire inspection revealed the residential portion of the property had never been inspected by fire officials.
Jeffrey Epstein death: Autopsy doctor explains delayed suicide ruling
The Epstein files include a never-before-seen interview with the doctor who conducted the autopsy on Jeffrey Epstein.
The dangerous lesson countries may take from the Iran war
Having a nuclear weapon has never looked more appealing.
What are plasticizers, and are they bad for our health?
Tests in Germany show children and teens are contaminated with banned plasticizers. You may never have heard of these potentially toxic chemicals, but they're everywhere, including clothes, cosmetics and food packaging.
SIX FIGURE BUSINESS ENTREPRENEUR, SPEAKER VAL VEE ANNOUNCES THE RELEASE OF HER NEW BOOK "FIGURED IT OUT: HOW DROPOUTS, MISFITS, AND RULE BREAKERS WIN"
FOR IMMEDIATE RELEASE Figured It Out How Dropouts, Misfits, and Rule Breakers Win TORONTO, CANADA, March 08, 2026 (GLOBE NEWSWIRE) -- Six Figure Business Entrepreneur, Speaker Slam champion Val Vagopoulos is announcing the upcoming release of her new book “Figured It Out: How Dropouts, Misfits, and Rule Breakers Win.” What if the rules you were told to follow were never meant for you? Val Vee was told what every kid is told: stay in school, get a safe job, and follow the path. She did the opposi
Unexplored deep-water worlds in Caribbean revealed for the first time
Scientists discover underwater mountain ranges, golden towers of coral, and never-before-seen sea creatures.
Mental health partnership strengthens care during LAMAT 2026 in Saint Kitts and Nevis
As the Lesser Antilles Medical Assistance Team (LAMAT) 2026 mission concluded in Saint Kitts and Nevis, mental health professionals from the U.S. Air Force and local providers reflect on the partnerships built and the impact of their collaboration on mental health care across the islands. Working under the guidance of the Ministry of Health, the LAMAT mental health team partnered closely with local clinicians to better understand community needs while supporting care for patients across multiple settings.
England's away-day blues - could they finally lose to Italy?
BBC Sport examines England's struggles as they aim to get their Six Nations back on track against a resurgent Italy in Rome - where they have never lost - on Saturday.
How is the Iran war reshaping the world and politics here at home?
For the last week, Israeli and US bombs have devastated Iran. And the conflict has widened to include multiple countries in the Gulf. How is the conflict reshaping the world order and impacting Trump’s popularity here in the United States?For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org. Email us at considerthis@npr.org.This episode was produced by Connor Donevan, Elena Burnett, Alejandra Marquez Janse and Erika Ryan. It was edited by Barrie Hardymon, Tara Neill, Dana Farrington, Jeanette Woods and Courtney Dorning. Our executive producer is Sami Yenigun.
Public health needs steady budgets – and federal funding uncertainty cause real harms, even if the money is later restored
Public health depends on long-term planning, and when that planning is interrupted, some programs never recover.
Slay the Spire 2 Dev Never Thought It Would Actually Pass Marathon in Steam Concurrents, Says Congratulations Post ‘Seems a Bit Meaner Than Intended’
Some might have thought Bungie’s Marathon was going to be the big launch on Steam this week, but it turns out Slay the Spire 2 has quadrupled Bungie's extraction shooter in terms of concurrent player numbers on Valve's PC gaming platform.
Michael Pollan explains why AI will never replicate human consciousness
Michael Pollan tells Scientific American why the science of consciousness may ultimately be too subject to our own conscious minds to crack
On the Farm, the Hidden Climate Cost of America’s Broken Health Care System
American farmers are drowning in health insurance costs, while their German counterparts never worry about medical bills. The difference may help determine which country's small farms are better prepared for a changing climate.
Pittsburgh Steelers Considered Landing Spot for 4-Time Pro Bowler
You can never have enough talent in the NFL.