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A path toward justice and public safety

Strangulation can be one of the most dangerous forms of assault; despite the lack of visible ailments it is accompanied by. Though strangulation leaves no broken bones, bruises or visible wounds, it is one of the strongest predictors of future homicides for domestic violence victims. Until this year, second-degree assault by strangulation was not classified […]

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Sep 9 • 3:00 AM EDT • Politics • coloradopolitics.com
Alleged victim of Alan Jones looked ‘sunken and diminished’, politician tells court

Downing Centre court hears that the alleged victim was usually outgoing but his demeanour changed at a meeting with Jones at his apartment

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Sep 9 • 2:00 AM EDT • Politics • theguardian.com
Legislators receive science education center proposal

Legislators on the Interim Joint Committee on Education recently expressed interest about boosting Kentucky’s science education while hearing a proposal for the creation of the Kentucky Center for Science Education.

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Sep 9 • 1:00 AM EDT • Science • messenger-inquirer.com
Cleveland Clinic, RIKEN and IBM Team Advance to Finals for 2026 ACM Gordon Bell Prize

Joint research team modeled a 12,635-atom protein, the largest-known to be simulated using quantum computers. Breakthrough was achieved through quantum and classical methods working together, expanding quantum-centric supercomputing’s potential in life sciences research.

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Sep 9 • 12:01 AM EDT • Science • newsroom.clevelandclinic.org
Jacks look to continue playing ‘fresh’ in Week 3

SIOUX FALLS, S.D. (KELO) — SDSU fell to 1-1 on the season after a 34-18 loss at Northwestern over the weekend. The Jacks struggled to convert in the red zone but otherwise hung around with the Wildcats for the majority of the night, only trailing by two with eight minutes to go in the fourth. […]

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Sep 8 • 11:55 PM EDT • Sports • sports.yahoo.com
Health-oriented Korean rice bowl restaurant opens on Whitney Avenue

BIBIM, a new venture from the owner of bb.q Chicken, aims to offer affordable, healthy Korean fare in a customizable form. In its opening week, the restaurant has sold 1,000 bowls, according to a manager.

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Sep 8 • 10:11 PM EDT • Health • yaledailynews.com
[Spoilers] Persona 6 Achievement List Potentially Revealed

The trophy list for Persona 6 has potentially been revealed through backend sources via Exophase.

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Sep 8 • 8:58 PM EDT • Technology • personacentral.com
Cleveland Clinic, RIKEN and IBM Team Advance to Finals for 2026 ACM Gordon Bell Prize

Cleveland Clinic, RIKEN and IBM has been named as a finalist for the 2026 ACM Gordon Bell Prize for simulating the largest biologically meaningful molecules ever modeled with quantum computers, reaching a scale of 12,635 atoms.

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Sep 8 • 8:00 PM EDT • Science • newsroom.ibm.com
Geologists reveal the Americas collided millions of years earlier than thought

Volcanic rocks in Colombia are rewriting the timeline of the collision between Central and South America. Their magnetic signatures show that major tectonic deformation had already weakened by the late Miocene, suggesting the most intense collision occurred earlier than previously believed.

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Sep 8 • 8:00 PM EDT • Science • sciencedaily.com
What to watch as Republicans gather in Dallas for Trump's unusual midterm convention

Midterms are often difficult for the party in power in Washington, and Trump believes the event can juice enthusiasm for the party and boost turnout among his voters.

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Sep 8 • 7:49 PM EDT • Politics • pbs.org
Harrisburg Senators unveil 2027 schedule

HARRISBURG, Pa. (WHTM) — The Harrisburg Senators unveiled their 2027 season Tuesday. The Senators’ home opener is Friday, April 2, against the Chesapeake Baysox. The team will host 69 games at FNB Field. Other notable home games include Mother’s Day on May 9 vs. the Richmond Flying Squirrels, as well as Memorial Day weekend through […]

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Sep 8 • 6:54 PM EDT • Sports • sports.yahoo.com
Steelers rookie Max Iheanachor has home broken into

Steelers rookie has home broken into.

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Sep 8 • 6:38 PM EDT • Sports • sports.yahoo.com
$30 million maintenance bill looms over Roanoke’s aging entertainment venue

A laundry list of decay, broken equipment, and failing infrastructure inside the aging building has left the city facing an estimated maintenance and repair bill of at least $30 million

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Sep 8 • 6:36 PM EDT • Entertainment • wdbj7.com
Canada, Kentucky's top trading partner, launches retaliatory tariffs

Canada has slapped new retaliatory tariffs on a range of American goods, in response to those imposed by the U.S. on Canadian products last month.

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Sep 8 • 6:28 PM EDT • Politics • ny1.com
Canada, Kentucky's top trading partner, launches retaliatory tariffs

Canada has slapped new retaliatory tariffs on a range of American goods, in response to those imposed by the U.S. on Canadian products last month.

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Sep 8 • 6:28 PM EDT • Politics • spectrumnews1.com
Washington’s Deuce Davis Continues Havoc at EDGE

Sunday afternoon saw the first reps that Russell "Deuce" Davis II has taken since his three-sack performance in the UCLA game of 2024. That year, he played just 34 defensive snaps before injuries sidelined him for all of 2025. In the Apple Cup, Davis recorded a sack on his first play back. He appeared on …

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Sep 8 • 6:22 PM EDT • Sports • sports.yahoo.com
Three-time MVP Aaron Judge returns to Yankees

BRONX, N.Y. (WIVT/WBGH) – Sticking with the diamond, let’s move up to the major leagues where the Yankees are set to welcome back the captain tonight. Aaron Judge is making his return in the pinstripes tonight. No. 99 ironically had a 99-day absence after he suffered a broken rib. The three-time AL MVP missed 84 […]

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Sep 8 • 5:47 PM EDT • Sports • sports.yahoo.com
Monster Jam coming to Gwinnett this weekend

Long before she made a name for herself on the insanely popular Monster Jam circuit, Kayla Blood approached and cleared her share of hurdles.

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Sep 8 • 5:37 PM EDT • Entertainment • gwinnettdailypost.com
From Backyard Ziplines to Self-Driving Cars: UCLA Computer Science Student Develops Tools to Help Autonomous Vehicles Safely Share Information

One of the fondest childhood memories of Alexandra Markova was a weekend spent running around Home Depot with her father and three siblings.

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Sep 8 • 5:32 PM EDT • Science • samueli.ucla.edu
Browns news: Deshaun Watson a team captain for Week 1

The Cleveland Browns and head coach Todd Monken have opted to deploy captains on a week-to-week basis this year, rather than instill season-long captains. The team is young and still trying to figure things out, and Monken believes there are more leaders on the team than just five. Monken will name two offensive, two defensive, and one special […] The post Browns news: Deshaun Watson a team captain for Week 1 appeared first on ClutchPoints.

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Sep 8 • 5:23 PM EDT • Sports • sports.yahoo.com
Sports law professor explains the Clippers and Kawhi Leonard’s NBA punishments

Ken Jacobsen, director of Temple Law’s sports law program, discusses the recent Kawhi Leonard scandal and the heavy punishments being administered by the NBA.

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Sep 8 • 3:39 PM EDT • Sports • news.temple.edu
Sports law professor explains the Clippers and Kawhi Leonard’s NBA punishments

Ken Jacobsen, director of Temple Law’s sports law program, discusses the recent Kawhi Leonard scandal and the heavy punishments being administered by the NBA.

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Sep 8 • 3:39 PM EDT • Sports • now.temple.edu
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future

The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.

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Sep 8 • 3:12 PM EDT • Technology • gamefile.news
Scripps Sports Expands Nashville Predators Television Coverage to Seven Additional Markets Across Tennessee, Kentucky and Alabama

Multi-Year Media Rights Agreement Brings Predators Hockey to Broader Regional Audience With Comprehensive Broadcast Package

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Sep 8 • 3:00 PM EDT • Sports • nhl.com
Everton's Has Selection Headache Heading Into Tottenham Clash

Selection headaches are something a manager can often dream of, and David Moyes could have them heading towards Everton's game against Tottenham in the Premier League this weekend.

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Sep 8 • 2:12 PM EDT • Sports • sports.yahoo.com
Rabid skunk confirmed in Pickens County, health officials say

DPH announced Tuesday that a skunk found in the Upstate has tested positive for rabies.

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Sep 8 • 1:57 PM EDT • Health • wyff4.com
Area high school girls flag football players join GN Sports to talk about event this weekend
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Sep 8 • 1:52 PM EDT • Sports • sports.yahoo.com
Meet Rachel Chen, the 18-year-old Los Angeles student who expanded a 1997 quantum-math idea to describe entire particle systems with simple diagrams; she won $100,000

At just 18, Rachel Chen has taken a decades-old mathematical idea and expanded it into a visual framework for understanding complex quantum systems, earning her a $100,000 award in the 2026 Regeneron Science Talent Search.

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Sep 8 • 1:52 PM EDT • Science • timesofindia.indiatimes.com
Wisconsin alum, rapper Yung Gravy supports local business during Badgers vs Notre Dame game

GREEN BAY, Wis. (WFRV) – Matthew Hauri, better known by his stage and rapper name Yung Gravy, made an appearance in Green Bay over the weekend to support Wisconsin, his alma mater, in their g…

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Sep 8 • 1:34 PM EDT • Business • wearegreenbay.com
Penguins unveil roster for upcoming prospect tournament in Detroit

The Penguins have announced the roster for the team’s upcoming prospect tournament that’s being held in Detroit, starting this weekend. Pittsburgh, along with Columbus, Dallas and Detroit will be participating in a prospect tournament in Detroit with games on Saturday, Sunday and Tuesday. All of the games will be streamed on the Penguins’ website. 27 […]

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Sep 8 • 1:14 PM EDT • Sports • sports.yahoo.com
Cowboys Predicted to Add Champion George Pickens Replacement

The Dallas Cowboys could have a high-scoring offense with George Pickens back. But assuming he leaves after this year, could a college star replace him? The post Cowboys Predicted to Add Champion George Pickens Replacement appeared first on HEAVY.

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Sep 8 • 1:05 PM EDT • Sports • sports.yahoo.com
Honda Postpones Big Upgrades to 2027

The Japanese brand's trackside boss confirms no significant evolution this year. The AMR26's lack of top speed showed at Monza, with Alonso and Stroll posting the weekend's worst times.

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Sep 8 • 1:00 PM EDT • Sports • sports.yahoo.com
Devers Records Giants First 35/35 Season Since 2002

Rafael Devers joins Jeff Kent in the San Francisco Giants franchise record books, leveraging an explosive September power surge to make up for the team's horrific season.

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Sep 8 • 1:00 PM EDT • Sports • sports.yahoo.com
Vikings Re-Sign Edge Rusher Kenny Dyson To Practice Squad

Dyson is back with in Minnesota as the team was clearly impressed with his skillset.

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Sep 8 • 1:00 PM EDT • Sports • sports.yahoo.com
Russia launches massive, deadly, and ‘complex’ attack against Ukraine

Fighting between Ukraine and Russia commenced after a 72-hour pause for diplomatic visits to both countries by U.S. officials. Russia launched a massive attack on Ukraine on Tuesday, firing dozens of cruise missiles and over 140 drones as the war raged on after this weekend’s peace talks brokered by U.S. envoys Jared Kushner and Steve […]

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Sep 8 • 12:53 PM EDT • Politics • coloradopolitics.com
Carole Radziwill says ‘the emotions all came back’ when “Love Story” aired while she filmed her return to “RHONY”

Radziwill is related to John F. Kennedy Jr. through marriage; her late husband, Anthony Radziwill, and JFK Jr. were first cousins.

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Sep 8 • 12:48 PM EDT • Entertainment • yahoo.com
Dan Campbell Accidentally Leaks Tom Kennedy News

Dan Campbell accidentally revealed Tuesday that Tom Kennedy will play for the Detroit Lions in their Week 1 matchup against New Orleans.

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Sep 8 • 12:33 PM EDT • Sports • sports.yahoo.com
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The debate on whether WEC prioritised 'entertainment' over 'sport' in Austin

WEC hosted its Austin round last weekend, but did the series go too far in its pursuit of an entertaining race?

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Sep 8 • 12:28 PM EDT • Entertainment • autosport.com
Hunter Biden launching a laptop-themed cryptocurrency

Hunter Biden's $Laptop meme coin launches on Base blockchain, with 20% of tokens going to those who lost money on Trump's $TRUMP crypto coin.

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Sep 8 • 12:03 PM EDT • Business • foxbusiness.com
‘Antiques Roadshow’ appraisers coming to Fort Plain Museum

Leigh Keno and Joel Bohy of PBS’ “Antiques Roadshow” will offer appraisals during an Oct. 10 antiques show at the Fort Plain Museum.

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Sep 8 • 12:00 PM EDT • Entertainment • romesentinel.com
The Revue: No reward for UAPB’s courageous lions

THE GREAT AND POWERFUL TRUMAN HAS SPOKEN

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Sep 8 • 12:00 PM EDT • Sports • sports.yahoo.com
Former MSU Interim AD Jon Palumbo Heading to Kentucky

The Spartans’ leadership exodus continues as another top executive reunites with J Batt in Lexington, leaving East Lansing to navigate a shifting front office after months of transition.

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Sep 8 • 11:57 AM EDT • Sports • sports.yahoo.com
Paxton Aide Turned Whistle-Blower Appears in Ad Endorsing His Rival, Talarico

David Maxwell was among the staffers in the Texas attorney general’s office who accused Ken Paxton of abusing the power of his office, allegations that led to his impeachment. Mr. Paxton was acquitted.

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Sep 8 • 11:50 AM EDT • Politics • nytimes.com
Oil prices surge back toward $100: What market pros are saying

Oil is creeping back toward $100 a barrel, fueling a Labor Day record for US gas prices over the long weekend.

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Sep 8 • 11:19 AM EDT • Business • businessinsider.com
ON THE MARK: Acclaimed blues band Blueprints returns to Madison Hall

You don’t need an intricate plan to build a fun time this weekend.

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Sep 8 • 11:00 AM EDT • Entertainment • romesentinel.com
Kenya moves to regularize foreign businesses after president's remarks alarm immigrant communities

The Kenyan government on Tuesday gave foreigners running businesses in the country 90 days to obtain or update required documents, including work permits and business licenses. The move followed rema...

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Sep 8 • 10:52 AM EDT • Business • yahoo.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com
Sunderland 'deserved more' at Brentford

Marco Gabbiadini says Sunderland deserved to win at Brentford after taking the game to their opponents on Saturday. The former Sunderland striker, speaking to Radio Newcastle, believes the Black Cats' attacking approach could have earned them all three points and suggested the result could prove significant when looking back at the end of the season. "If you finish the season in a similar position to what we finished last season and you look back over it, you might look back and think this is one that could have taken us another place up the table," said Gabbiadini.

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Sep 8 • 10:47 AM EDT • Sports • sports.yahoo.com
Mackenzie, Bresnahan, McCormick To Speak at "Trumpapalooza" in Dallas

Pennsylvania will be well represented at the podium as the Republican Party holds a midterm national convention in Dallas on Wednesday and Thursday. A pair of GOP congressmen - Reps. Ryan Mackenzie (R-07) and Rob Bresnahan (R-08) - and Sen. Dave McCormick will be among the 109 officials, candidates and…

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Sep 8 • 10:41 AM EDT • Politics • politicspa.com
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Cleveland Armenian Festival returns to Richmond Heights this weekend

St. Gregory of Narek Armenian Church hosts the annual event Friday evening and all day Saturday.

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Sep 8 • 10:31 AM EDT • Entertainment • cleveland.com
Juventus fans attack their team’s mindset over Federico Gatti’s celebration

Federico Gatti saved the day for Juventus when they faced AC Milan at the weekend, but his reaction after scoring has frustrated the club’s fans.The Bianconeri were the better team during the match,...

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Sep 8 • 10:06 AM EDT • Sports • sports.yahoo.com
Oil prices keep rising and weigh on Wall Street

U.S. stocks are drifting lower in their return to trading following a three-day weekend. The S&P 500 dipped 0.2% Tuesday. The Dow Jones Industrial Average fell 477 points, and the

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Sep 8 • 9:45 AM EDT • Business • kake.com
Harrison Smith Returns — And the Cap Gets Complicated

Harrison Smith's $12.25M return, cap concerns, bold predictions, and an NFL Rivalry Weekend pitch.

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Sep 8 • 9:25 AM EDT • Sports • sports.yahoo.com
Hormuz disruptions hitting small businesses hardest, UN trade agency warns

GENEVA, Sept 8 (Reuters) - Disruptions in the Strait of Hormuz could push small and medium-sized businesses out of global supply chains, increasing economic concentration and weakening the resilience

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Sep 8 • 9:01 AM EDT • Business • lufkindailynews.com
Hormuz disruptions hitting small businesses hardest, UN trade agency warns

GENEVA, Sept 8 (Reuters) - Disruptions in the Strait of Hormuz could push small and medium-sized businesses out of global supply chains, increasing economic concentration and weakening the resilience

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Sep 8 • 9:01 AM EDT • Business • finance.yahoo.com
Scientists confirm Newton’s gravity law

Gravity has survived its largest-scale test yet, holding up across distances of up to 230 megaparsecs, or about 750 million light-years. University of Pennsylvania physicists found that the force weakens with distance almost exactly as Newton’s equations predict, a relationship later incorporated into Einstein’s theory of general relativity. Galaxies and galaxy clusters move faster than...

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Sep 8 • 9:00 AM EDT • Science • theticker.org
North Country Sports Scoreboard: Tuesday, Sept. 8, 2026

The Labor Day weekend did see some North Country sports teams in action on Sunday and Monday.

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Sep 8 • 8:45 AM EDT • Sports • sports.yahoo.com
Nashville business on the brink of closing saved by weekend holiday rush; What's ahead?
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Sep 8 • 8:26 AM EDT • Business • fox17.com
Environmental Health Message from Supervisor Perez

As the Supervisor Fourth District, infrastructure, social services, and Economic Development are critical in building a healthy environment.

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Sep 8 • 8:15 AM EDT • Health • ukenreport.com
September 8 Playbook: Fetterman Hits Back

🥱 Welcome Back. Hope you enjoyed your holiday weekend. 🎶 Your Morning Pick Me Up. Welcome Back. John Sebastian PA Weather☀️ Erie | Mostly Sunny, 77🌤️ State College | Partly Sunny, 81☀️ Allentown | Mostly Sunny, 81 PA Sports ⚾ Phillies (81-63, -4.0 GB, +4.5 GB WC) | Atlanta 1-0 |…

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Sep 8 • 8:07 AM EDT • Politics • politicspa.com
(BPRW) ProcuraFind® and Ally Financial Announce Strategic Initiative to Advance Small Business Growth Through Education, Readiness, and Opportunity

(Black PR Wire) Charlotte, N.C. — ProcuraFind® and Ally Financial announced a strategic, multi-year agreement focused on helping small businesses build stronger companies through education, financial empowerment, supplie...

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Sep 8 • 8:00 AM EDT • Business • blackprwire.com
Message for Mbappé? Lamine Yamal: title winners all press

Lamine Yamal has spoken at a press conference ahead of Barcelona-Feyenoord. The Champions League as a challenge"There is no greater motivation for me than winning the Champions League, it’s the most...

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Sep 8 • 7:41 AM EDT • Sports • sports.yahoo.com
Daniel Farke provides fitness update ahead of Chelsea clash

After a quick turnaround following the weekend’s Premier League draw at Brighton & Hove Albion, attentions now turn to the trip to Chelsea for Wednesday’s EFL Cup Round Three tie for Daniel Farke�...

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Sep 8 • 7:04 AM EDT • Sports • sports.yahoo.com
Kerjota transformative - but has he earned a start?

If Hearts' mentality was in question after that late collapse against Aberdeen just over a month ago, Sunday's stoppage-time winner from Sabah Kerjota offered a pretty emphatic response. This was a side showing the resilience Wouter Vrancken is trying to build. VAR Andrew Dallas intervened in two major incidents missed by referee Chris Graham, while the introduction of supersub Sabah transformed hope into genuine belief.

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Sep 8 • 6:53 AM EDT • Sports • sports.yahoo.com
Kenny Minchey had a historic debut for Kentucky Football

Kenny Minchey adds his name to an exclusive list of Kentucky quarterbacks

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Sep 8 • 6:05 AM EDT • Sports • sports.yahoo.com
Inhaled Microplastics Linked To Lung Cancer, Study Finds

By Dennis Thompson HealthDay ReporterTUESDAY, Sept. 8, 2026 (HealthDay News) — People with lung cancer are more likely to have hidden deposits of microplastics in their lungs, a new study says. About 66% of lung cancer patients had detectable microplastics found in fluid samples taken from their ...

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Sep 8 • 6:00 AM EDT • Health • usnews.com
Islanders News: Eyes on Eiserman, Gold

Not a lot of “news” fodder coming out of a long holiday weekend in the U.S., but Labor Day is behind us and training camp is now on the horizon. Islanders News Elsewhere

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Sep 8 • 6:00 AM EDT • Sports • sports.yahoo.com
Judging leadership is not a science

Jared Diamond's survey of leaders through history underrates the degree to which evaluating leadership is a subjective art.

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Sep 8 • 5:49 AM EDT • Science • engelsbergideas.com
Pink Chicken's Customers Outgrew Its Kids' Clothes. The Brand Grew With Them, Into an 8-Figure Business

The 20-year-old company expanded from kidswear into baby, teen, and women’s categories by listening to the families already shopping it.

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Sep 8 • 5:00 AM EDT • Business • inc.com
Battle Creek event offers wellness and lead safety information

Families can explore health programs, community services and lead safety information at a free Calhoun County event Oct. 10.

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Sep 8 • 4:45 AM EDT • Health • battlecreekenquirer.com
Worthing sign forward Kendall from Southend

Worthing sign Southend United forward Charley Kendall for an undisclosed fee.

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Sep 8 • 4:06 AM EDT • Sports • sports.yahoo.com
Keeping kids safe on ATVs

As ATV-related injuries among Kentucky children continue to rise, experts encourage parents to choose age-appropriate vehicles, require helmets and protective gear, and follow safe riding practices to help prevent serious injuries and deaths.

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Sep 8 • 4:00 AM EDT • Health • uknow.uky.edu
Christian Watson Issues Clear Harrison Smith Message Before Vikings Game

The Minnesota Vikings defense received a major boost this past weekend as Harrison Smith returned on a one-year contract. Moreover, the reported contract is worth $12.25 million, with a maximum value of $16.25 million, per NFL Network’s Ian Rapoport and Mike Garafolo.Minnesota will have its QB on defense relaying what defensive coordinator Brian Flores wants the […] The post Christian Watson Issues Clear Harrison Smith Message Before Vikings Game appeared first on HEAVY.

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Sep 7 • 11:43 PM EDT • Sports • sports.yahoo.com
Jackrabbits fueled by missed opportunities

BROOKINGS, S.D. (KELO) — The SDSU Jackrabbits marched into Evanston, Illinois this past weekend to take on Northwestern, and despite many trips inside Wildcat territory the big play never came. The Jacks made seven total trips inside the Northwestern 20-yard line but only came away with a touchdown one time. Head Coach Dan Jackson says […]

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Sep 7 • 11:08 PM EDT • Sports • sports.yahoo.com
‘We will stand together’: Power of unions grows in Central Valley’s political world

While laborers across the U.S. are enjoying the three-day weekend, the work isn’t done yet.

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Sep 7 • 9:46 PM EDT • Politics • kget.com
Bottas Wins Gun Runner For Second Straight Stakes Triumph

Miguel Clement-trained Vekoma colt drove between horses and collared pacesetter Conducted in the final sixteenth at Kentucky Downs to get the victory

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Sep 7 • 9:31 PM EDT • Sports • sports.yahoo.com
SEC flashes dominance in historic opening week

Kentucky Football did its part in a historic SEC opening weekend. See how history was made.

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Sep 7 • 9:07 PM EDT • Sports • sports.yahoo.com
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Los Angeles Dodgers Announce Shohei Ohtani Decision Before Reds Game

After sweeping the Washington Nationals over the weekend, the Los Angeles Dodgers are beginning a new series in MLB on Labor Day Monday. They are squaring off against the Cincinnati Reds and hope to keep their 4-game winning streak alive against Reds’ starter Chase Burns. The Dodgers lineup has looked a little different over the […] The post Los Angeles Dodgers Announce Shohei Ohtani Decision Before Reds Game appeared first on HEAVY.

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Sep 7 • 9:04 PM EDT • Sports • sports.yahoo.com
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New indoor family entertainment center in Mt. Juliet opens for Labor Day weekend

Good Clean Fun! Family Entertainment Center features arcade games, a pirate themed blacklight mini-golf course, a 7D ride and more. It held its grand opening Saturday.

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Sep 7 • 8:41 PM EDT • Entertainment • newschannel5.com
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Cincinnati, Northern Kentucky high school sports scores, Sept. 7-13

A look at Northern Kentucky and Cincinnati high school sports scores reported to The Enquirer from September 7 to September 13.

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Sep 7 • 8:20 PM EDT • Sports • sports.yahoo.com
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How Art Uncovers the Hidden Pain of Endometriosis

See how ANU PhD candidate Susanne Ilschner goes beyond the diagnosis and clinical data, using abstract paintings to give voice to the unspoken pain of women living with endometriosis.

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Sep 7 • 8:00 PM EDT • Science • science.anu.edu.au
Mt. Juliet's new indoor family entertainment center opens just in time for Labor Day weekend

Mt. Juliet's new indoor family entertainment center opens just in time for Labor Day weekend

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Sep 7 • 7:55 PM EDT • Entertainment • newschannel5.com
Political notes: Ivey co-chairs CBCF, Ausby to Appellate Court, another Haley honored

Rep. Glenn Ivey (D-4th) co-chairs the annual conference of the Congressional Black Caucus Foundation at a challenging time for the caucus, Simon Haley is honored at UMES and Kendra Young Ausby is elevated to an Appellate Court judgeship, in political notes.

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Sep 7 • 7:30 PM EDT • Politics • marylandmatters.org
Kentucky Dem: Secrecy surrounding Sen. McConnell’s health part of why voters don’t ‘trust’ DC
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Sep 7 • 7:24 PM EDT • Politics • cnn.com
Richmond County Fair draws its biggest crowd ever for 3 days of food, rides and tradition

Since 1980, Historic Richmond Town has proudly hosted the Richmond County Fair on every Labor Day weekend.

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Sep 7 • 6:35 PM EDT • Entertainment • silive.com
Stanford's Test Will Come Against Duke

The Stanford defense was walloped by the Miami Hurricanes over the weekend, but that was to be expected. Now with an extra week to prepare, the game against Duke will be the Cardinal's big litmus test for 2026.

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Sep 7 • 6:08 PM EDT • Sports • sports.yahoo.com
Businesses welcome Labor Day weekend customer surge

It's been a busy weekend for businesses on the Lakeshore with Labor Day weekend being the unofficial end of summer. (Sept. 7, 2026)

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Sep 7 • 5:40 PM EDT • Business • woodtv.com
Giants' Vitello Gets Candid About Tumultuous Season

San Francisco Giants manager Tony Vitello has not had an easy year, but it has not broken his resolve.

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Sep 7 • 5:00 PM EDT • Sports • sports.yahoo.com
Kentucky lawmaker renews push for domestic violence offender registry

People convicted of a qualifying offense would appear in a public database after a second conviction.

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Sep 7 • 5:00 PM EDT • Politics • spectrumnews1.com
Todd Monken Weighs in on Browns QB Rumors

Cleveland Browns head coach Todd Monken has weighed in on all the rumors surrounding the team's quarterback situation.

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Sep 7 • 4:54 PM EDT • Sports • sports.yahoo.com
Arsenal continue to track highly rated Serie A attacker

Arsenal were keen to sign Kenan Yildiz in the last transfer window and made that clear as they tried to find an opening to make their move, but Juventus insisted that he was not on the market.Yildiz i...

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Sep 7 • 4:15 PM EDT • Sports • sports.yahoo.com
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Monken doesn't rule out Browns using rookie QB in offensive 'package' Week 1 at Jaguars
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Sep 7 • 3:35 PM EDT • Sports • sports.yahoo.com
A Weekend Full of Wins for the Cantera Rojiblanca!

The Cantera Rojiblanca faced another busy weekend of action on Matchdays 7 and 8 of the Apertura 2026, with our young players once again showing their Rojiblanco DNA and competitive spirit. Their perf...

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Sep 7 • 2:58 PM EDT • Sports • sports.yahoo.com
'Down to a science': Labor Day barbecue goes off without a hitch

WHATELY — Strolling through the Whately Congregational Church’s parking lot around noon on Monday brought to life the unmistakable aroma of boiled corn. But this was just a hint of what was going on inside. Parishioners once again rolled up their sleeves on Labor Day to dole out purchased meals of a barbecued half-chicken, fresh […]

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Sep 7 • 2:19 PM EDT • Science • recorder.com
Midterm elections head into the home stretch as candidates hit Labor Day events

Candidates in key November races are spending Labor Day weekend stumping at festivals, union halls and parades

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Sep 7 • 1:53 PM EDT • Politics • spectrumlocalnews.com
Midterm elections head into the home stretch as candidates hit Labor Day events

Candidates in key November races are spending Labor Day weekend stumping at festivals, union halls and parades

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Sep 7 • 1:53 PM EDT • Politics • ny1.com
Midterm elections head into the home stretch as candidates hit Labor Day events

Candidates in key November races are spending Labor Day weekend stumping at festivals, union halls and parades

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Sep 7 • 1:53 PM EDT • Politics • spectrumlocalnews.com
New Mexico Democrats push back over Trump posts about renaming the state ‘New America’

The president posted repeatedly on social media over the weekend, and New Mexico Democrats leaped to respond to the ones about their state.

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Sep 7 • 1:36 PM EDT • Politics • nbcnews.com
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How ‘cornflakes’ can help decode ancient writing

The breakfast cereal could never.

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Sep 7 • 1:17 PM EDT • Science • popsci.com
African Bizav Strives for Greater Market Opportunity

Industry group presses for regulatory progress and continuity across the continent

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Sep 7 • 1:00 PM EDT • Business • ainonline.com
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