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Contract dispute could push White River Medical Center out-of-network with UnitedHealthcare
The city of Batesville is facing a looming healthcare crisis.A contract dispute between the White River Medical Center and the private insurance giant UnitedHe
Science Central’s planetarium opens Wednesday
Get ready to gaze up at the night sky inside 21Country’s only public planetarium. Science Central opened its highly anticipated project Wednesday.
Political donations in cryptocurrency could be blocked in blow to Reform UK
Government review also recommends political funding from Britons living abroad be capped at about £300,000 a year
Spotter report: YouTube-led shows are reaching legacy TV levels
A new Spotter report says creator shows are approaching the output of legacy TV. The startup wants advertisers to shift spending.
Plans for forum to replace scrapped USC governor's debate fall apart
A proposed forum cobbled together after USC canceled its gubernatorial debate fell apart as candidates of color excluded from the previous event were unable to show up in person, sources said.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Paranovus sells 14.3M shares at 35 cents to raise $5M
A single institutional investor agreed to buy the shares, with closing set for about March 25. Paranovus says net proceeds will fund working capital.
Epic Games cuts 1,000 jobs as Fortnite 'magic' fades in 'extreme' market conditions
Epic Games is laying off over 1,000 employees as CEO Tim Sweeney cites declining Fortnite engagement and spending that exceeds the company's revenue.
Epic Games cuts 1,000 jobs as Fortnite 'magic' fades in 'extreme' market conditions
Epic Games is laying off over 1,000 employees as CEO Tim Sweeney cites declining Fortnite engagement and spending that exceeds the company's revenue.
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Jewelry Extravaganza to raise funds for Millsboro library
On April 16-18, the Friends of the Millsboro Public Library will be presenting their annual Jewelry Extravaganza fundraiser, the proceeds from which will be used to support the children’s summer
Iran war starts to hit global economy, business surveys show
The Iran war is already taking a toll on major economies around the world, according to business surveys on Tuesday which showed how a surge in energy prices and rising uncertainty were dampening activity and pushing inflation expectations higher.
Exit polls suggest Italy's Meloni has narrowly lost justice referendum vote
Exit polls on Monday suggested Italian Prime Minister Giorgia Meloni had narrowly lost a referendum on her flagship reform of the judicial system, dealing a potential blow to the ruling coalition ahead of next year's general election.
Cardinal Health Appoints Patricia A. Hemingway Hall as Board Chair
/PRNewswire/ -- Cardinal Health (NYSE: CAH) today announced that its Board of Directors has appointed Patricia A. Hemingway Hall to succeed Gregory B. Kenny as...
Funding for populist-right ‘media-political complex’ exceeded £170m in five years, research finds
Handful of billionaires gave huge sums in particular to media organisations that boosted rightwing politicians, says Liam Byrne MP
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
American football takes for ever. In which other sports do you spend most of your time not playing the game?
The long-running series in which readers answer other readers’ questions on subjects ranging from trivial flights of fancy to profound scientific and philosophical concepts
Franklin Templeton CEO Jenny Johnson on the values needed to keep a billion-dollar business in the family
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RJ promotes Traci Wilson to vice president of digital strategy
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Billionaire John Caudwell's rules for parenting his 8 kids
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In Business, Why Creating Value Wins
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A public health professor is bringing the National Bioethics Bowl to Pitt
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Philadelphia Eagles' dynamic duo named one of NFL's best
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Maine Democratic Senate primary grows increasingly bitter as party vies to unseat Susan Collins in key race
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Trump is failing at the business of war
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Boost your small business with this resource fair
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Cue Biopharma Reports Fourth Quarter and Full Year 2025 Financial Results and Business Highlights
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Merlin and Inflection Point Acquisition Corp. IV Announce Closing of Business Combination
Merlin's Cessna Caravan Merlin's aircraft flying overhead at the company's Quonset, RI hangar Merlin's Quonset, RI Hangar A C-130J flying overhead at Merlin’s Quonset, RI hangar Transaction provides more than $200M in gross proceeds to accelerate commercialization of AI-powered autonomous aviation Merlin to Begin Trading on March 17th on the NASDAQ Under Ticker Symbol “MRLN” BOSTON, March 16, 2026 (GLOBE NEWSWIRE) -- Merlin, Inc., an aerospace and defense technology company building the operatin
Opinion: New Book Helps Teachers Implement Science of Reading in Their Classrooms
Get kids reading fluently. As much as you can. Have them read and write about books. That, more or less, is the key to translating the science of reading into classroom practice, according to a new bo...
What to expect in the Illinois state primary
Topping the ballot is the race to succeed Democratic U.S. Sen. Dick Durbin.
Children's Healthcare CEO to retire after 40 years with hospital
Donna Hyland will step down as CEO and will be succeeded by Patrick Frias.
Sports gambling was supposed to create new revenue. Instead it's damaging college scholarships
Tennessee's sports gambling tax revenue exceeds $100 million but the state's Lottery-funded scholarship program faces an $80 million deficit.
6 memorable moments from Conan O'Brien's second time hosting the Oscars
This is the second time in a row the talk show host emceed the show.
Stars deliver modern and colorful looks on Oscars red carpet
For Hollywood’s biggest night, celebrities pay as much attention to their speeches as to their red-carpet attire. It’s a night to leave a mark not just on Hollywood but on
Michael B. Jordan thanks Black Oscar winners who came before him in emotional Best Actor speech
Michael B. Jordan overtakes Timothée Chalamet to win Best Actor at the Oscars for 'Sinners.'
Oscars red carpet sees pops of color as stars arrive
For Hollywood’s biggest night, celebrities pay as much attention to their speeches as to their red-carpet attire. It’s a night to leave a mark not just on Hollywood but on
10 projects from Newsom’s mental health bond were supposed to open in 2025. That didn’t happen
No project expected in 2025 under Gov. Gavin Newsom’s mental health ballot measure have opened. He says the bond is exceeding its goals.
Players Championship: Two killed in parking lot near TPC Sawgrass, tournament opening delayed
In what police are calling a domestic incident, two people were shot and killed near the site of The Players Championship.
Iran war deprives US farmers of affordable fertilizer as spring planting looms
Farmers in the U.S. and Canada, who were already worried about prospects for another year of low profits or losses, now could have spring planting disrupted as they struggle to find fertilizer, and prices for any available supplies have spiked more than a third since the war in Iran paralyzed global trade.
Should the U.S. be in business of assassinating foreign leaders?
In the opening strike of their war on Iran, the US and Israel killed the Islamic Republic’s supreme leader, Ayatollah Ali Khamenei. It is an exceedingly rare instance of democracies killing a foreign head of state.It’s not the first time the United States has been involved in the killing of a foreign leader, but it’s something U.S. leaders and the American public have long wrestled with. NPR’s Ryan Lucas reports. For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org. Email us at considerthis@npr.org.This episode was produced by Mallory Yu and Erika Ryan, with audio engineering by Jay Czys.It was edited by John Ketchum and Anna Yukhanov. Our executive producer is Sami Yenigun.
Vaxart Provides Business Update and Reports Full Year 2025 Financial Results
Topline data from 400-person sentinel cohort of the Phase 2b COVID-19 trial anticipated early Q2 2026 Published positive clinical results in the first quarter of 2026 demonstrating oral norovirus vaccine candidate was safe and immunogenic in lactating women and resulted in passive transfer of antibodies to their infants via breast milk Cash, cash equivalents and investments of $63.8 million as of December 31, 2025; Runway into second quarter of 2027 Conference call today at 4:30 p.m. ET Live sto
Hampton & Peninsula Health Dirstricts Urge You to Plan Ahead For Spring Severe Weather
From 1980 to 2024, Virginia experienced more than 100 severe weather events, each with losses exceeding $1 billion. (Adobe Stock)
Ravens-Bills matchup gains intrigue after Hendrickson, Chubb deals
The Ravens-Bills 2026 matchup now carries added intrigue after Baltimore signed Trey Hendrickson and Buffalo landed former Dolphins pass rusher Bradley Chubb.
🏀 Y! Sports AM: 83 points!
Bam Adebayo just kept scoring. And scoring. And scoring. And scoring.
California Democrats Have Made a Mess of the Governor’s Race
As the California Democratic Party gathered in San Francisco last month for its convention, reporters had a frequent question for the retiring political king- (and queen-) maker, former House Speaker Nancy Pelosi: Was her state really on the verge of electing a Republican to succeed Governor Gavin Newsom, as a growing number of partisans had begun to fear?
Haleon makes oral-health push in China as other Western brands falter
Haleon is stepping up its Chinese expansion, pushing into second- and third-tier cities and tailoring its gum-health products to local tastes, aiming to succeed where many Western consumer brands have struggled.
Beloved Buc-ee's convenience store chain faces customer service crisis after devastating 'F' rating
Buc-ee's received a shocking "F" rating from the Better Business Bureau, despite a massive cult following and aggressive expansion plans across 11 states nationwide.
Debra Lee to Receive Icon Award at Black Women in Entertainment Honors (EXCLUSIVE)
Former BET chairman and CEO Debra Lee will receive the Icon Award at the inaugural Black Women in Entertainment honors ceremony. Black Women in Entertainment is a national network and inclusive collec...
Debra Lee to Receive Icon Award at Black Women in Entertainment Honors (EXCLUSIVE)
Former BET chairman and CEO Debra Lee will receive the Icon Award at the inaugural Black Women in Entertainment honors ceremony. Black Women in Entertainment is a national network and inclusive collec...
Ed Martin, outspoken Justice Department lawyer, is formally accused of ethical violations
Ed Martin, an outspoken Trump administration official, is facing attorney discipline proceedings in Washington, DC, for a letter he sent to Georgetown Law about its diversity programs, the district’s professional conduct investigator announced on Tuesday.
Trump says he's 'not happy' with Iran's choice of new supreme leader
President Donald Trump said he's "not happy" with Iran's new supreme leader choice as Mojtaba Khamenei takes power. Military operation results exceed expectations
JFK Jr.'s cousin speaks out on Daryl Hannah's 'Love Story' portrayal after actress' scathing essay
Douglas Kennedy defends Daryl Hannah after the Grammy-nominated actress called out Ryan Murphy's 'Love Story' for her portrayal in the FX series: 'I think that's a misrepresentation.'
Leave the Scouts out of Washington’s politics
We want to see Irving-based Scouting America succeed.
In new memoir, Gov. Gavin Newsom reflects on his political rise
As California’s governor – and a topic of discussion among some as a possible 2028 presidential candidate – Gavin Newsom is an exceedingly public figure with a busy schedule to match. His new memoir, Young Man in a Hurry, provides a glimpse into Newsom’s rise to political prominence and his ongoing goal of self-discovery. In today’s episode, Newsom sits down with NPR’s Ailsa Chang to discuss his book, the question of his own relatability, and why he uses “playground insults”’ on social media to push back against the Trump administration.To listen to Book of the Day sponsor-free and support NPR's book coverage, sign up for Book of the Day+ at plus.npr.org/bookoftheday
UCLA mauled Iowa and proved the Bruins can win a national title
The UCLA women's basketball team rolled to a 51-point win over Iowa in the Big Ten tournament title game, showing it deserves the No. 1 overall seed.
KKR eyes multibillion-dollar sale of data center cooling company, FT reports
U.S. private equity firm KKR is working with advisers on a sale of data center company CoolIT Systems for a price tag potentially exceeding $3 billion, the Financial Times reported on Sunday, citing people familiar with the matter.
Life Time Des Moines hosts fundraiser for children's health
Workout fundraiser at Life Time Des Moines raises money for Children’s Miracle Network and the Life Time Foundation, with local proceeds benefiting Stead Family Children’s Hospital.
Apple Adds Three Executives to Leadership Page
Apple on Friday added three new executive profiles to its leadership page for Jennifer Newstead, Molly Anderson, and Steve Lemay. Jennifer Newstead, Senior Vice President and General Counsel: Newstead is Apple's top lawyer, overseeing all legal matters. She assumed the position on March 1, succeeding Katherine Adams, who had held the position since 2017. Prior to joining Apple, Newstead served as Meta's chief legal officer for six years.
Employment seekers gather at Trumbull County Business Expo in Girard
A portion of the proceeds made from general admission will benefit the Warren Family Mission, a non-profit organization that provides shelter, food, services and programs for those in need.
How young Seattle musicians celebrate jazz culture
Through different school programs and community stages, Seattle youth are continuing to allow for jazz to live and breathe, writes Raisbeck Aviation student Thien-Nhi Nguyen.
Lonza hands off capsule business to investment firm Lone Star in $3B deal
Lonza is at long last shedding its capsules and health ingredients (CHI) business in a private equity sale that could see proceeds of 3 billion Swiss francs ($4 billion) or more. | Under the deal with Lone Star Funds, Lonza maintains a 40% stake in its capsules and health ingredients business while receiving 1.7 billion Swiss francs ($2.2 billion) upfront.
Columbus builds "women's sports capital" momentum
An NWSL bid and major events spotlight the city's ambitions.
First-ever championship of new extreme sports league coming to Superdome this summer
The inaugural X Games League championship event will feature big-name musical headliners performing at the Smoothie King Center, organizers said.
Business rebates for energy upgrades
The City, in partnership with the Center for Energy and Environment (CEE), offers rebates for businesses making energy-efficiency improvements.
Wayne State University partners with Michigan Science Center for Brain Day
Exclusive: Greater Good Health raises $33 million
The company is eyeing profitability by the end of 2027.
‘A subversion of the justice system’: DoJ shifts into Trump’s ‘political wing’ as criminal investigations accelerate
President has ‘succeeded in completely politicizing’ justice department, experts say, using it to punish his enemies
A 7-Year-Old Boy’s Death Inflames Anger Over Colombia’s Health Crisis
Polls now show whoever succeeds Gustavo Petro will have to prioritize cleaning up the mess left by his failed reforms and costly feud with medical insurers.
"Bonded By Evolution: The Science of Love and Connection" explores what we prioritize in romantic re
"They feel like they can succeed with a backcourt of …
"They feel like they can succeed with a backcourt of …
Cosm sets opening date, adding new Atlanta attraction ahead of World Cup
A large new entertainment venue is set to open this summer in downtown Atlanta, and its timing couldn’t be better.
Towns take the temperature on support for universal health care
Several Vermont towns have voted on a measure urging the Legislature to reconsider single-payer health care.
Is regime change really possible in Iran?
Inbuilt structural power makes Tehran authorities difficult to overthrow, as Ayatollah’s son tipped to succeed him
How should HR handle politics in the workplace?
When an employee’s political expression interferes with business operations, HR must know how to proceed, writes David Urban, senior counsel at Liebert Cassidy Whitmore.
Mamdani seeks to succeed where others stalled in Sunnyside
The site has drawn major proposals for nearly a century.
Queens Councilmember Vickie Paladino to face disciplinary proceedings
Paladino has until the end of the week to formally respond.
Progressive lawmakers Bernie Sanders, Ro Khanna unveil $4.4T wealth tax targeting billionaires
Progressive lawmakers Bernie Sanders and Ro Khanna unveil a 5% annual wealth tax on billionaires' assets exceeding $1 billion to fundamentally reshape America's current tax system.
This congressman wanted to retire. His identical twin could make history by replacing him
Should Trever Nehls win his Tuesday primary in Texas’ 22nd District and then the general election, he would become the first member of Congress to succeed his identical twin in office.
Santiago Bernabeu demanded Florentino Perez’s resignation after Getafe defeat
Last night ended in frustration at the Santiago Bernabeu. Real Madrid’s 0-1 defeat to Getafe was a loss that sparked a reaction from the stands that made the mood inside the stadium impossible to i...
How Trump’s war on Iran could succeed — or go disastrously wrong
Pete Hegseth on Monday betrayed the bombast often seen at the shock-and-awe openings of American military campaigns as he promised certain victory in the new war with Iran.
Former president of Marion business convicted of federal bankruptcy crimes
A former president of a now-defunct Marion business was convicted of multiple federal bankruptcy crimes Monday after prosecutors say he concealed assets and provided false statements during his bankruptcy proceedings.
Patriots free agency profile: Vederian Lowe could be surprisingly popular
Previewing the Patriots offensive tackle as he heads into unrestricted free agency.