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New iPhone 18 specs report raises big question of iOS 27 limitations
Apple’s base model iPhone 18 might not get as much RAM as expected—raising questions about support for iOS 27’s most demanding features.
These Deals on Video Games, Controllers, and Peripherals Will Disappear When Prime Day Ends Tonight
These are the best last-chance gaming deals for the last day of Prime Day: Save on top video games like Elden Ring, plus premium controllers, gaming mice, and essential peripherals.
Jeffries: What happens in handful of primaries not ‘indicative of what needs to happen in November’
Black Health and Wellness Association holds event to provide healthcare options in North Omaha
Watch: The Black Health and Wellness Association hosted a community night to provide healthcare resources for North Omaha residents.
Making sense of what Lars Tiffany’s lawsuit says about UVA sports
Analyzing a few points made by Tiffany’s camp and what they indicate about the UVA athletic department’s approach.
Iran's Pride Match is about visibility, not politics
Iran’s World Cup match against Egypt has become a test not only of FIFA’s approach to inclusion but also of whether LGBTQ+ Iranians can claim visibility on one of the world’s biggest sporting stages.
Falco In Star Fox Is Every Toxic DPS You've Ever Played With
‘I could use some of that teamwork!’
CSUF Report Finds Family Businesses Drive Jobs and Revenue in Fullerton
The city of Fullerton is home to a vibrant entrepreneurial community, with family-owned businesses serving as a cornerstone of the local economy. The family business sector in Fullerton is the subject of a new report researched and published by Tim Schultz, the head of Cal State Fullerton’s Center for Family Business. Chethan Srikant, associate professor […]
Apple's OLED 'MacBook Ultra' Will Stick With M5 Pro and M5 Max Chips
Apple's upcoming high-end MacBook model featuring an OLED touchscreen display will use the company's current M5 Pro and M5 Max chips, according to Bloomberg's Mark Gurman. The new, top-of-the-line device will launch "between late this year and early next year," Gurman said, adopting the existing high-end Apple silicon chips rather than next-generation M6 versions.
Business owner in South Carolina arrested, officials say
A business owner in South Carolina was arrested Friday and is accused of operating without a retail license, according to the South Carolina Department of Revenue.
Summer Science Program
Explore information about the Summer Science Program at Arkansas Children's Hospital, a career readiness program for college students, including eligibility and how to apply.
Two Yankees Pitching Prospects ‘Turning Heads’ in Minors This Year
The old saying is you can never have enough pitching, which the New York Yankees have apparently taken to heart. The Yankees have a stockpile of potential starting-pitching arms in the minor leagues, including Elmer Rodriguez, and two “head turning” prospects, Ben Hess and Chase Hampton. The Yankees lead the majors in team ERA (3.30) […] The post Two Yankees Pitching Prospects ‘Turning Heads’ in Minors This Year appeared first on HEAVY.
New iPhone Ultra report has new pricing and release timing info
Apple’s highly anticipated foldable iPhone is launching this fall, but a new report today claims you might have to wait...
Apple’s Touch MacBook to Use M5 Pro and Max Chips, With M7 Models to Follow
Apple Inc.’s first-ever touch-screen laptop will rely on the company’s current high-end M5 chips, rather than next-generation silicon, though the company is working on a follow-up model with future M7 processors.
Jackson business owner charged with murder after 21-year-old man shot
A suspected vehicle break-in ended in gunfire in Jackson. Police say the business owner now faces murder charges after the 21-year-old victim died during surgery.
Master Inventor Hoffman Turns Chemistry Into Capability | Johns Hopkins University Applied Physics Laboratory
Christopher Hoffman has been recognized as a Johns Hopkins APL Master Inventor, a distinction earned through a career spent asking a simple question: What can chemistry can do to solve a real-world problem?
Last Chance To Fix Destiny 2 Delayed After Bungie Lays Off Devs
Bungie is running out of chances to set things right in its sci-fi MMO before it's left behind for good
Vance Downplays Watergate and Compares Himself to Nixon
The vice president said that the scandal that ended Richard Nixon’s presidency would be “like a 12-hour news story” if it happened today and that the “deep state” had taken down Nixon.
Dragon's Dogma 2: Dark Arisen: What We Learned In Capcom's Showcase
Kento Kinoshita, Dragon's Dogma: Dark Arisen's original director, is returning for Dragon's Dogma 2: Dark Arisen
Andy Cohen cries as he mourns 28-year-old 'WWHL' producer who died of brain cancer
Andy Cohen became emotional mourning 'Watch What Happens Live' production manager Kyra Samson, 28, who died of brain cancer earlier this week.
iPhone 18 Pro and Foldable iPhone Tipped to Get Price Hikes Too
Apple's iPhone 18 Pro lineup and its first foldable iPhone will launch at higher prices than originally predicted this September, according to several known Chinese leakers.
Meet A Retriever—Manikanta Sirumalla, International Data Science Graduate Student And Entrepreneur - UMBC: University Of Maryland, Baltimore County
If you want help meeting a big new fitness goal, Manikanta Sirumalla may have the app for you. Manikanta came to UMBC from India as a graduate student
How Brad Pitt appears in “Jackass: Best and Last”: 'It was wild,' says Steve-O
The "Inglourious Basterds" actor shows up in the latest "Jackass" movie via archival footage from 2001.
Texas school board to vote on required Bible readings in public education
If approved by the Texas State Board of Education, which is controlled by Republicans, the reading list would take effect in 2030.
Securitize and Cantor Equity Partners II Business Combination Expected to Raise Approximately $400 million in Gross Proceeds and Announce Expected Closing of Business Combination and NYSE Listing
/PRNewswire/ -- Securitize, Inc. ("Securitize" or the "Company"), and Cantor Equity Partners II, Inc. (Nasdaq: CEPT) ("CEPT"), a publicly traded special...
Cannes Lions Entertainment Awards: Adidas Takes Home Grand Prix for Oasis ‘Original Forever’ Collaboration
The 2026 Cannes Lions International Festival of Creativity recognized the best creative campaigns across entertainment, design and craft categories. Sports apparel and footwear maker Adidas’ tie-up wi...
Cannes Lions Entertainment Awards: Adidas' Oasis Collab Wins Grand Prix
The 2026 Cannes Lions International Festival of Creativity winners across entertainment, design and craft categories were announced. Sports apparel and footwear maker Adidas' tie-up with English band Oasis winning the top prize in the Entertainment Lions category.
Framework lowers Laptop 13 Pro prices in response to Apple’s Mac price hikes
Framework has lowered some Laptop 13 Pro prices after switching to ADATA Gen 5 SSDs. Existing pre-orders with older Gen 5 SSD options will also be updated.
What Happens to Your Liver When You Drink Green Tea Every Day
What does green tea do for your liver? Learn how it may affect fat buildup, inflammation, and liver enzymes, plus risks and benefits.
Braille is literacy: Rice researchers are reshaping the science of reading
As schools across the country increasingly embrace evidence-based approaches to reading instruction through the science of reading, two Rice researchers are leading an effort to ensure students who learn through braille are not left out of the research shaping literacy education.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
New York is already exporting Mamdani-style politics
Some of the institutions behind Tuesday’s progressive surge are already supporting candidates around the country
Gemini begins rolling out for existing Android Automotive vehicles
Some months after its confirmation, Gemini for Android Automotive appears to be finally rolling out to existing vehicles.
Happy birthday, 2000 Year Old Man. Mel Brooks is turning 100
The 2000 Year Old Man is turning 100. Mel Brooks on Sunday will celebrate his centennial birthday. The comedian and filmmaker has been awaiting the milestone. Earlier this year, Judd
College Sports Communicators Recognize Strelow with Writing Awards
BOONE, N.C. — App State's award-winning strategic communications staff added more honors this spring, as Bret Strelow was recognized for two stories in the Fred Stabley Sr. Writing Contest that's conducted by the College Sports Communicators organization.
First Look: Breguet Releases 3 new Tourbillon Watches for the 225th Anniversary of its Invention
New takes on the Breguet Classique Tourbillon Sidéral, the Tradition Tourbillon and the Marine Tourbillon Équation Marchante.
Sugar is not uniquely bad for you. But it’s undermining good habits.
Is sugar more harmful than other carbohydrates? The evidence is far from compelling.
Federal AI security center measure advanced by House Science
A measure that would put into law a key federal office focused on artificial intelligence advanced Thursday out of the House Science, Space and Technology Committee, as part of a slate of AI-focused and data center bills. The committee advanced the bills on a bipartisan basis, but put off potential changes regarding funding levels for […]
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
SpaceX employees get rich off IPO while Blue Origin workers miss out
Three ex-employees of Jeff Bezos' rocket maker said Blue Origin's approach to equity left them with stock options that are essentially worthless.
How Outward Intelligence founders bootstrapped to seven-figure revenue
Three friends with résumés spanning Google, Palantir, and Harris Poll skipped venture capital and bootstrapped their startup instead.
These 15+ award-winning gadgets are on sale for Prime Day - but we'd pay full price
Editor-approved tech is still on sale during Amazon's Prime Day sale - but don't wait much longer to shop.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Apple to Skip M6 Pro and M6 Max, Jumps to M7 Series
Apple has reportedly canceled its M6 Pro and M6 Max processors, according to a recent note from Bloomberg's Apple insider Mark Gurman. Behind the scenes, there is a significant shift in Apple's silicon rollout strategy. The company is postponing the launch of its higher-end M6 SoC variants, like the...
'The Vampire Lestat's Sam Reid on Magnus, Claudia, Sofia, and more
Would Lestat listen to Chappell Roan? Asked and answered.
Cabo Verde Is a Breakout Star of the World Cup. So Is the Family-Owned Business That Designed Its Jerseys
After more than three decades manufacturing apparel, Capelli Sport co-founder and CEO George Altirs found his company’s biggest billboard yet—3,500 miles away from his midtown Manhattan office.
This Democratic congresswoman almost helped elect a Republican speaker
Rep. Marcy Kaptur (D-Ohio) explains why she contemplated supporting Rep. Kevin McCarthy (R-California) in 2023 with an extremely rare crossover vote.
World Cup brings a boost to bar and restaurant businesses across the Piedmont-Triad
Bars and taprooms across the Piedmont-Triad are extending their hours and providing the ultimate experience as the World Cup enters its second week.
Opinion | Don't apply politics to scientific research
Under recently proposed rules, federal grants could be terminated midstream for reasons having little to do with science or merit.
Apple orders 9x fewer display panels for the foldable iPhone Ultra than for the iPhone 18 Pro
Reportedly, Cupertino orders "only" 10 million panels for its first-ever foldable phone.
Professor Willow’s Birthday Research
Starts Tuesday, July 21, 2026, at 10:00 AM Local Time Ends Tuesday, July 21, 2026, at 8:00 PM Local Time Wish Professor Willow a very happy birthday with Professor Willow’s assistant Pikachu! This adorable Pikachu makes their Pokémon GO debut as part of the Willow’s Birthday Research event along with GO Snapshots, raids and more […]
Reasoning For Pitching Prospect's Absence From Rehab Assignment Revealed
Left-handed pitcher Ricky Tiedemann didn't make an appearance in his rehab assignment in Single-A due a separate injury than the one he's recovering from.
Smart voices in business react to Apple and Xbox price hikes
After Apple and Microsoft's Xbox raised prices due to a shortage of memory chips, tech observers are not optimistic about future prices.
How an Iowa junior college became a sports giant
DMACC athletic programs are quietly dominating through coaching and player performance
Proposed Changes to Grant Rules Threaten the Future of Research: Scientists Must Act Now!
The Trump administration is seeking to politicize US federal science funding, but collective action can stop this grantpocalypse from happening.
Elliot Cadeau appears set to return to Michigan basketball roster
For the third and presumably final time this offseason, Elliot Cadeau appears to have confirmed he will stay with Michigan basketball.
At least two people shot near Birmingham business
Just after 8:30 p.m., Birmingham police confirmed two victims in the shooting.
iHeart-broken: Listeners react to mass layoffs at local sports radio station
iHeart lays off radio hosts at three of its four stations in Des Moines.
Sharonville mom raising money for UC Health's ICU patient program after she nearly died
It's been a year since a Sharonville mom suffered a medical emergency days after giving birth to her second child.
Vance dismisses Watergate scandal, says ‘deep state’ went after Nixon
The vice president said he admired Nixon and drew parallels between the past president, who resigned amid pressure in 1974, and Trump today.
Controversial billionaire tax will appear on November ballot
Proponents of a controversial billionaire tax pledge to making sure it appears on the November ballot to backfill federal healthcare funds.
It's Summer Sale Season, So I Tracked Down 25 Actually Good Gaming Deals Under $20
There's a million sales happening right now, so I sifted through them all to find 25 genuinely solid gaming deals that are each under $20.
It's Xbox's turn (again), as console prices keep going up
Microsoft announced a price hike for the Xbox Series consoles today, the third in little over a year. Effective August 1, the Xbox Series S, which launched in 2020 for $300, will cost $500 in the U.S. The Xbox Series X, which launched in 2020 at $500, will go for $800. This follows a round of PlayStation 5 price increases from Sony this spring, and a slow-motion increase for Nintendo’s Switch 2, which will kick in in the U.S. in September. (Mind you, there were also eight video game industry price hikes in six months of 2025). The chart up top shows the sudden ascent of console prices over the past year, a sudden surge in an already unusual hardware generation. Prices had been flat for years, now “up” is the new “flat.” Game console prices used to go down across the length of a console generation, but not this time around. Microsoft’s explanation for the new price hike today: We hoped another price increase would not be necessary, and we have spent the last several months working with suppliers on options. Unfortunately, console storage and memory prices have increased by more than 2.5x and we expect another doubling by the fall of 2027. The entire consumer electronics industry is struggling with the current components crisis, but the effects are particularly hard on consoles. Unlike phones, computers, speakers, and other consumer devices, consoles are typically not sold at a profit, but instead for less than they cost to make. This is an issue well beyond game consoles. Apple announced price hikes on its computers and tablets today as well. Game File is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Item 2: Brutal Bungie cuts Bungie laid off “most” of its Destiny development team and some developers who worked on Marathon, the newest game from the struggling Sony-owned studio. A WARN notice issued by Sony to Washington State, where Bungie is based, tallied cuts impacting 292 workers, effective next month. That’s strictly for Bungie/Sony jobs in Washington and wouldn’t account for any elsewhere. The video I clipped below shows the redacted list of Bungie cuts filed to Washington State officials. As you’ll see, I had to scroll for a while… In a note emailed to PlayStation workers and published online, PlayStation game studios chief Hermen Hulst offered the following explanation for these latest cuts at Bungie: This is painful news, especially for talented colleagues whose roles have been eliminated. This decision was made only after extensive discussion and careful consideration, and I want to provide some context on how we arrived here. Over the past several months, together with Bungie leadership, we reviewed the studio’s long-term direction, development priorities, resource needs, and role within our broader portfolio strategy. We explored multiple alternatives before concluding that a reduction was necessary to align the studio’s resources with its current priorities and long-term goals. In 2022, Sony bought Bungie for $3.7 billion. The studio’s marquee game, the multiplayer live service shooter Destiny 2 was losing popularity at the time. Its next game Marathon, released earlier this year, has been well-reviewed but had a slow start. Bungie is renowned for making great shooter games, and Destiny fans have mourned the wind-down of Destiny 2. They’ve also expressed bewilderment over reports that Destiny 3 is not, per Bloomberg, immediately in the cards.
This Is Probably Your Last Chance to Buy a Cheap MacBook for a While
Apple has dramatically jacked up the price of MacBooks, making the current Prime Day pricing that much more enticing.
Dopant-localized mechanoluminescence in simple oxides
Light: Science & Applications - Dopant-localized mechanoluminescence in simple oxides
Evaluating the robustness and readiness of large frontier models in health AI applications
Nature Medicine - Adversarial evaluation of leading AI models uncovers gaps between benchmark success and robustness, highlighting limitations in current health AI benchmarks and their ability to...
Need for bread | Unexpected closure of Terranetti's Bakery has left several businesses scrambling
Terranetti's Bakery closes, and local shops are scrambling for bread
2026 World Cup Is Putting FIFA’s Rules on Political Neutrality to the Test
The World Cup is in full swing across North America, and the U.S. men’s team faces Turkey in its final group round appearance on Thursday. But behind the cheering fans and nail biting matches, FIFA's commitment to political neutrality is put to the test. Marisa sits down with Tariq Panja, global sports correspondent at The New York Times. They dig into the politics behind the games, from restrictions on Iran’s team and President Trump’s unusually close relationship with FIFA president Giann
M6 MacBook Pro Expected This Year With Apple's First 2nm Chip
Apple could launch an updated base model 14-inch MacBook Pro with an M6 chip as soon as this year, reports Bloomberg. There could also be M6 chip updates for the Mac mini, iMac, and MacBook Air, but Apple is testing an M6 MacBook Pro. Apple plans to introduce the M6 in late 2026, and for the first time, it will be a standalone chip. Apple is not working on M6 Pro or M6 Max chips, and will hold off on higher-end chip options until the M7 series launches in 2027.
Blakeman slams Lander in TV interview over Israel stance
On Thursday, the Republican doubled down in a statement to NY1.
Vance, an admirer of Richard Nixon, says Watergate would be 'a 12-hour news story' today
Vice President JD Vance says the Watergate scandal that brought down President Richard Nixon would have been a blip in today’s news cycle
Valve Deletes 4K 60FPS Claim From Steam Page After Reviews
Some have struggled to hit consistently high framerates on the new hardware
Asthma, maternal health, climate disasters: How Detroit’s health director is tackling city’s health disparities
Detroit health director discusses tackling childhood asthma, maternal health, climate disasters through Health in All Policies approach.
Dolly Parton makes surprise appearance — complete with a joke
Dolly Parton just made a surprise appearance, complete with her trademark humor, amid health issues.
40+ Steam Summer Sale Games That Are Just $10 Or Less
You can get Dead Island 2, Devil May Cry 5, The Witcher 3, and Ghostwire Tokyo for just $20 right now on Steam
Inside Trump’s plans for retribution and other lesser-known allegations in ‘Regime Change’
A new book from two Washington reporters reveals what took place inside the White House after President Donald Trump’s return to power.
Monkey Business: Wild rhesus macaque spotted at Mount Dora hotel
A wild rhesus macaque was spotted at the historic Lakeside Inn in Mount Dora, Florida, spending about 45 minutes roaming the property and attracting attention from guests and staff. The hotel and local businesses responded with humorous, monkey-themed social media content, engaging the community. Wildlife officials cautioned the public not to approach or feed wild monkeys due to potential health risks and encouraged reporting sightings to authorities. The monkey has not returned to the hotel but has been seen elsewhere in downtown Mount Dora.
This autism therapy is covered by many insurers. Why does the military’s plan restrict it?
Logan Cabiao started applied behavior analysis therapy for autism when he was 2. Several years later, TRICARE, the military’s healthcare program, imposed major coverage restrictions.
Stonepeak reveals $2.53B offer for Chicago parking meter lease
Stonepeak disclosed its $2.53 billion bid for Chicago's parking meter lease as it urged skeptical aldermen to approve the transfer and criticized the Johnson administration.
Watch: 2026 High School Sports Awards
The 4th annual 6 Sports High School Awards event is happening on Thursday.
Lucky the Bull Gets a Transformation
A local artist has been working for weeks on restoring a historic landmark that will soon be making a public appearance.
Business Council deliberations continue with four bill drafts
Lawmakers on the Joint Appropriations Committee spent another day diving through the Wyoming Business Council’s dealings. This time, they also reviewed draft bills that would influence how the council operates.
M5 Ultra Mac Studio Could Launch in 2026 With Up to 768GB of RAM
Despite price increases across the Mac line, Apple is still planning to release a new Mac Studio as soon as this year, reports Bloomberg. Apple plans to introduce a new M5 Ultra chip as the final option in the M5 family before it transitions to the M6, M7, M7 Pro, and M7 Max. The M5 Ultra will come in a new version of the Mac Studio, which hasn't been updated since March 2025.
Supreme Court hands Trump major victories on his immigration agenda
In two ideologically spit rulings that could affect millions, justices say the administration can deport some migrants and turn others away at the border.
Santa Ana Star Casino Hotel launches app, unveils July entertainment lineup
Santa Ana Star Casino Hotel offers comedy, entertainment, perks, and more. In July, the casino has a lineup of comedians and other entertainment. July Entertainment Lineup June 26, 27 – Carme…
FlashPoint: How a Christian political media network became a platform for Indiana’s Lt. Gov.
By Sydney Byerly The Indiana Citizen June 25, 2026 When Indiana Lt. Gov. Micah Beckwith called Islam a “demonic death cult” during an appearance on the Christian political program FlashPoint in May, the remarks drew swift backlash from faith leaders across Indiana. It also highlighted the growing influence of the Christian media network that amplified
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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