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Man completes 12,000-mile walk across America’s four corners in Lubec for mental health awareness

Kyndal Ray Edwards, a mental health coach from Jacksonville, Florida, crossed the finish line at West Quoddy Head Lighthouse in Lubec on Sunday afternoon after visiting all four corners of the contiguous United States. Along the way, he raised funds for the nonprofit Never Alone Recovery.

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Oct 25 • 9:14 PM EDT • Health • wabi.tv
The best apps for tracking your reading and discovering new books

There are many apps that are designed to help you track your reading and discover new books, so we compiled a list of some of the best ones.

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Oct 25 • 9:10 PM EDT • Technology • techcrunch.com
What's fair game in politics?

Jim Lokay discusses the controversy over Vivek Ramaswamy's attack ad involving his opponent Amy Acton's estranged mother, plus how affordability arguments are shaping the last week of the midterm campaign with Andrew Donaldson of Ordinary Times.

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Oct 25 • 9:08 PM EDT • Politics • fox5dc.com
Il Volo celebrates nearly 20 years of musical harmony

Longer than many marriages and most rock bands, the Italian singing trio Il Volo have been together for almost 20 years. They’ve gone from teenagers to 30-somethings while selling more

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Oct 25 • 9:00 PM EDT • Entertainment • floridaweekly.com
🚨 Line-ups confirmed for América

América hosts Pachuca tonight at Estadio Banorte on Matchday 14 of the Apertura 2026, looking to secure top spot, while Tuzos will go all out to reach the playoffs despite their slim chances.América...

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Oct 25 • 8:58 PM EDT • Sports • sports.yahoo.com
IN GOOD HEALTH: Preparing for respiratory illness season

By Leanna Coy, FNP-BC As temperatures begin to cool and the holiday season gets underway with Halloween this month, it’s time to prepare for fall and winter respiratory illnesses. As we…

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Oct 25 • 8:45 PM EDT • Health • tillamookcountypioneer.net
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😐 Neutral (18%)
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Politics Unplugged (Full Episode) Oct. 25, 2026

On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.

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Oct 25 • 8:31 PM EDT • Politics • azfamily.com
JESPY Trivia Friendraiser

Put your trivia skills to the test for a great cause! Join JESPY for a fun-filled Trivia Night on Sunday, November 8, 2026, from 5–8 p.m. at Avenue Pub in Maplewood.Gather your friends, enjoy some...

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Oct 25 • 8:30 PM EDT • Entertainment • tapinto.net
Detroit Lions vs. Minnesota Vikings Point Spread Revealed

The Detroit Lions are 3-point favorites against the undefeated Minnesota Vikings in Week 8. See the latest FanDuel point spread, moneyline, and total.

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Oct 25 • 8:18 PM EDT • Sports • sports.yahoo.com
Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing

Peyton Manning is one of the greatest players, if not the greatest, to ever play for the Indianapolis Colts. The former quarterback is one of the most decorated players in American football history. He has won the Super Bowl two times, and is a five-time NFL Most Valuable Player. The Colts have not found the […] The post Peyton Manning’s Role in Colts GM Search Clarified After Chris Ballard Firing appeared first on Gridiron Heroics.

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Oct 25 • 8:08 PM EDT • Sports • sports.yahoo.com
Scientists discover Arctic sea ice loss could be far worse than predicted

Arctic winter sea ice could disappear much faster than scientists previously expected, according to new research using climate clues from 6,000 years ago. By comparing ancient ocean sediments with modern climate models, researchers found that future winter ice coverage may be roughly one million square kilometers smaller than earlier predictions suggested.

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Oct 25 • 8:00 PM EDT • Science • sciencedaily.com
Kings’ Mogbo Wants To Set Defensive Tone in G League

Armed with a 7-foot-2 wingspan and relentless hustle, the two-way forward aims to spark Stockton’s defense through gritty rebounding and elite shot-contesting while eyeing a permanent NBA promotion.

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Oct 25 • 7:36 PM EDT • Sports • sports.yahoo.com
Teddy Roosevelt Erred on Neanderthals

Just recently, paleontologists have found Neanderthal wooden tools (62-40 kya) preserved in stone.

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Oct 25 • 7:28 PM EDT • Science • scienceandculture.com
Vikings just proved why nobody wants to face Minnesota

The Minnesota Vikings have one real strength on their squad.

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Oct 25 • 7:15 PM EDT • Sports • sports.yahoo.com
Health network adding helicopter in rapid Pennsylvania expansion

WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System…

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Oct 25 • 7:15 PM EDT • Health • abc27.com
Health network adding helicopter in rapid Pennsylvania expansion

WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System recently...

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Oct 25 • 7:15 PM EDT • Health • yahoo.com
Aaron Jones will have an MRI on his knee
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Oct 25 • 7:14 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
The Dominant Buccaneers' Offensive Line Everyone Expected Finally Showed Up

The Bucs dominated the Carolina Panthers on Sunday, and the offensive line played its best game of the season.

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Oct 25 • 7:13 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-5%)
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Donald Trump praises Nicki Minaj’s ‘beautiful ass’ during rally speech: ‘It’s hard to miss’

Donald Trump made a lewd comment at the lectern while speaking at a Michigan rally about the anatomy of one of his strongest supporters, Nicki Minaj.

ew.com logo
Oct 25 • 7:01 PM EDT • Entertainment • ew.com
Most Windows users are seriously underusing this powerful desktop feature

Don't miss out on one of Windows' best multitasking and productivity features that gives you more room to work.

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Oct 25 • 7:00 PM EDT • Technology • engadget.com
9th Circuit panel questions basis for feds' request to block 20,000 California ballots

Two judges questioned the Justice Department's lawyer about how the Trump administration's position squared with the law.

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Oct 25 • 6:54 PM EDT • Politics • latimes.com
What’s going on with AJ Dybantsa’s ankle injury?

The Washington Wizards have started off playing well this season, and they’ve done so without the No. 1 overall pick. AJ Dybantsa hasn’t made his NBA debut yet as he deals with an ankle injury, and it looks like he’ll have to keep waiting after the latest update on his status, according to Brett Siegel of ClutchPoints. “AJ Dybantsa will remain […] The post What’s going on with AJ Dybantsa’s ankle injury? appeared first on ClutchPoints.

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Oct 25 • 6:53 PM EDT • Sports • sports.yahoo.com
Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury

The Minnesota Vikings saw running back Aaron Jones Sr. go down with a leg injury late in their Week 7 game against the Indianapolis Colts. The post Vikings’ Aaron Jones Exits Colts Contest With Scary-Looking Injury appeared first on HEAVY.

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Oct 25 • 6:40 PM EDT • Sports • sports.yahoo.com
Shia LaBeouf waged one-sided feud with Hilary Duff, says “Even Stevens” costar

Duff’s own Disney Channel series, “Lizzie McGuire,” was one of the Disney Channel’s defining hits of the 2000s.

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Oct 25 • 6:22 PM EDT • Entertainment • yahoo.com
Shia LaBeouf waged one-sided feud with Hilary Duff, says ‘Even Stevens’ costar

Christy Carlson Romano says her ‘Even Stevens’ costar, Shia LaBeouf, was ‘beefing’ with Hilary Duff during their overlapping Disney Channel days: ‘He had to be the number one.’

ew.com logo
Oct 25 • 6:22 PM EDT • Entertainment • ew.com
49ers' First Loss Makes It Clear: Their Toughest Opponent Is Their Health

The 49ers picked up their first loss of the season on Sunday, but it wasn't what the Falcons did that caused them to stumble.

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Oct 25 • 6:11 PM EDT • Health • foxsports.com
Matthew Stafford breaks Rams franchise record for touchdown passes

LAS VEGAS (AP) — Matthew Stafford added another milestone to his NFL career on Sunday, throwing his 155th touchdown pass for the Los Angeles Rams to break the franchise record.Stafford surpassed Roman Gabriel, who threw 154 TD passes for the Rams from 1962-72.

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Oct 25 • 6:11 PM EDT • Sports • sports.yahoo.com
Democrat Coumba Kebe wants to keep the politics out of the treasurer’s office

Political newcomer Coumba Kebe is the Democratic nominee for Indiana state treasurer. Kebe wants to keep the politics out of the office and build back trust with people.

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Oct 25 • 6:03 PM EDT • Politics • purdueexponent.org
After testing all major mobile browsers, this one finally earned my default spot

Looking beyond Chrome paid off with the best browser experience

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Oct 25 • 6:00 PM EDT • Technology • androidpolice.com
iFixit iPhone Duo Teardown Points to Possible Cause of Screen Cracks
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Oct 25 • 5:43 PM EDT • Technology • macrumors.com
Hinge damage suspected to be behind iPhone Duo screen cracks

The cause behind a repeating pattern in the way a very small amount of iPhone Duo screen cracks may have been discovered, with a failing element of the hinge believed to be causing the most damage.

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Oct 25 • 5:28 PM EDT • Technology • appleinsider.com
Jalen Coker not a big factor in Week 7

Panthers WR Jalen Coker caught only one of four targets in Week 7 and posted only nine yards

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Oct 25 • 5:13 PM EDT • Sports • sports.yahoo.com
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🎥 Kylian Mbappé's lucky goal against FC Barcelona

Kylian Mbappé opened the scoring against FC Barcelona this Saturday, October 25.A truly unexpected goal.With both teams looking sluggish from the start, it took until the 42nd minute for the deadlock...

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Oct 25 • 4:52 PM EDT • Sports • sports.yahoo.com
🙂 Positive (33%)
T.J. Hockenson finds end zone in Week 7 vs. Colts

Minnesota Vikings tight end T.J. Hockenson posted four receptions for 35 yards and a touchdown on five targets in Week 7

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Oct 25 • 4:51 PM EDT • Sports • sports.yahoo.com
Vučić concedes defeat in Serbian elections, says student movement won

The election was seen as a referendum on Vučić’s political dominance and the political system that has been in place in Serbia for more than a decade.

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Oct 25 • 4:51 PM EDT • Politics • euronews.com
Bryce Young throws one TD, two INTs in Week 7

Panthers QB Bryce Young finishes with season-low 163 yards and doubles INT total

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Oct 25 • 4:45 PM EDT • Sports • sports.yahoo.com
Remembering Freddie Freeman’s Iconic Walk-Off Grand Slam

Los Angeles Dodgers first baseman Freddie Freeman hit one of the most important home runs in Dodgers history two years ago, today.

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Oct 25 • 4:42 PM EDT • Sports • sports.yahoo.com
Historic Texas theater sold to New York wellness business

Not everyone is happy about this development.

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Oct 25 • 4:31 PM EDT • Business • chron.com
New Sistersville General Hospital marks milestone with final beam signing

Memorial Health System celebrated a milestone for the new Sistersville General Hospital with a final beam signing ahead of its 2027 opening, marking progress on expanded rural health care.

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Oct 25 • 4:17 PM EDT • Health • wtap.com
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Kyler Murray throws for 150 yards, TD in Week 7

Minnesota Vikings quarterback Kyler Murray completed 14 of 24 passes for 150 yards, one touchdown and no interceptions in Week 7

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Oct 25 • 4:16 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
A YouTuber dissected an iPhone Duo and thinks he found the cause of crackgate

A weak spot in the hinge may be failing and cracking iPhone Duo screens.

theverge.com logo
Oct 25 • 4:16 PM EDT • Technology • theverge.com
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.

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Oct 25 • 4:11 PM EDT • Politics • pbs.org
Liverpool working towards deal for star; could reach €90m

Liverpool are reportedly in the mix for a very in-demand France star. They’re working towards a deal and it’s one that could cost €90m.Liverpool are weighing up their transfer targets for the up...

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Oct 25 • 4:10 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Ex-Spur Jeremy Sochan becomes a Legend

The Dallas Legends used the top pick in Saturday's G League draft on Sochan, who will look to salvage an NBA career that has not gone as expected for the former lottery selection.

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Oct 25 • 3:53 PM EDT • Sports • sports.yahoo.com
Barcelona host Real Madrid in anticipated Clásico clash

2026-10-25T20:12:58ZThere have been a few crunching tackles on both sides in the last few minutes and now the benches have taken exception as there is a little coming together in the center of the par...

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Oct 25 • 3:33 PM EDT • Sports • sports.yahoo.com
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
Des Moines bishop says White House 'exploited' visit for politics

Bishop William Joensen was one of several invited to the White House for a private meeting they say is being used for "partisan political purposes."

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Oct 25 • 3:28 PM EDT • Politics • desmoinesregister.com
Science 4 Everyone: How does sod and tall fescue work?

Science teacher and Storm Team4 Meteorologist Ryan Miller explains how to use sod in your yard to prepare for cooler weather.

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Oct 25 • 3:27 PM EDT • Science • nbcwashington.com
‘I was doing all the right things': What one survivor's diagnosis reveals about breast cancer risk

A new survey and a survivor's experience reveal a gap between what women think puts them at risk and what actually does.

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Oct 25 • 3:20 PM EDT • Health • nbcmiami.com
Supercurrent enables the reading of quantum information without destroying it

One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...

phys.org logo
Oct 25 • 3:00 PM EDT • Technology • phys.org
Retire Your Old Fountain: The Alternative From Home Depot Perfect For Your Small Patio

The Teamson Solar Gray Stone Wall Fountain from Home Depot is a great fountain for small patios thanks to its compact size and solar powered design.

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Oct 25 • 3:00 PM EDT • Technology • housedigest.com
🚨 Barcelona & Real Madrid name XIs for El Clásico

Barcelona and Real Madrid face off in El Clásico this evening. Hansi Flick's Barcelona top La Liga this season after winning all nine matches.Real Madrid will hope for improvements this evening as L...

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Oct 25 • 2:54 PM EDT • Sports • sports.yahoo.com
Who's running to be Oklahoma's next Commissioner of Labor?

Republican Kevin West, Libertarian Mike Hall and Democrat Kevin Dawson will face off in November to be the next Commissioner of Labor.

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Oct 25 • 2:46 PM EDT • Politics • kgou.org
‘I love spending time with them’: Lewis Hamilton opens up about Kim Kardashian’s kids

Lewis Hamilton and Kim Kardashian have been one of the most talked-about couples in sports and entertainment this year, but the seven-time Formula 1 world champion has rarely said much about the relat...

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Oct 25 • 2:28 PM EDT • Entertainment • yahoo.com
Defender turns striker and scores in Bayern win

Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...

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Oct 25 • 2:27 PM EDT • Sports • sports.yahoo.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Blanche told CNN's “State of the Union” that President Donald Trump, who said Friday that he was "the one that said do it,” is not trying to overturn state election results “in any way, shape or form” on the cusp of the Nov. 3 election.

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Oct 25 • 2:19 PM EDT • Politics • pbs.org
Phantom Blade Zero Preload Time & Date Revealed; Clocks in at 145 GB as PC Requirements Listed

While a lot of PS5 gamers are eagerly awaiting Phantom Blade Zero, some might not know that the game is also releasing day and date on PC. If you're one…

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Oct 25 • 2:15 PM EDT • Technology • mp1st.com
Navigating D1 pressure: how student-athletes balance their mental health

Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...

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Oct 25 • 1:59 PM EDT • Health • nmsuroundup.com
Detectives seek information about business conducted with Piedmont Memorial Park Cemetery

Detectives are seeking information from anyone who has conducted business involving the cemetery since January 2019.

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Oct 25 • 1:59 PM EDT • Business • wxii12.com
How To Build A Cheap Home Server To Save Money On Subscriptions

You can turn an old laptop, a computer, or even a Raspberry Pi into a cheap media server, but it's best to run a Linux distribution for maximum compatibility.

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Oct 25 • 1:17 PM EDT • Technology • bgr.com
Nico Williams publicly disavows his agent over Barcelona transfer claims

Barcelona’s long and drawn-out pursuit of Nico Williams has become one of the more familiar sagas of recent transfer windows.The Athletic Club winger ultimately opted to stay at San Mames, snubbing ...

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Oct 25 • 1:17 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Clatsop County health inspections for September

Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]

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Oct 25 • 1:10 PM EDT • Health • dailyastorian.com
New Trump housing order targets mortgage and title insurers

A White House plan to pull private mortgage insurance off loans sooner, and to let refinancing borrowers skip the lender's title policy, affects two insurance lines that say they already help keep costs down

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Oct 25 • 1:09 PM EDT • Business • insurancebusinessmag.com
Argentina Folk Sounds, Controversy: Milo J, Cazzu, Broke Carey

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside and sharing their history with the world.

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Oct 25 • 1:09 PM EDT • Politics • rollingstone.com
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world

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Oct 25 • 1:09 PM EDT • Politics • yahoo.com
China Star Entertainment (SEHK:326) Stock Looks Richly Priced As Its 8.6x Run Continues

China Star Entertainment has logged very strong multi year share gains, so the key issue now is whether the current price can be supported by the value of assets on its balance sheet. For anyone looking at the stock today, the immediate question is how that share price lines up against its book value. Over the past 3 years the stock has returned about 8.6x. This puts a lot of weight on whether the underlying equity in the business justifies this kind of move when you compare it with the...

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Oct 25 • 1:06 PM EDT • Entertainment • finance.yahoo.com
Steelers beat Saints to win first NFL game in Paris

The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.

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Oct 25 • 1:03 PM EDT • Sports • sports.yahoo.com
😱Fans back Carrick: How the United players left

Today, Manchester United suffered another crushing defeat, losing 0-3 to Bournemouth at Old Trafford. There was plenty of talk during the week about the rift between the players and Michael Carrick, p...

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Oct 25 • 12:44 PM EDT • Sports • sports.yahoo.com
Warren, Steelers stiff-arm Saints for 16-10 Paris win

Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.

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Oct 25 • 12:42 PM EDT • Sports • sports.yahoo.com
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department

BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.

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Oct 25 • 12:27 PM EDT • Health • newjerseyhills.com
Kansas at Duke: Exhibition OGT

Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]

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Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
😐 Neutral (6%)
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One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie

Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.

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Oct 25 • 12:17 PM EDT • Entertainment • yahoo.com
The rise and fall of Route 66

Route 66 was one of America's most popular highways, driving business to small towns. But today, the road and its people have been largely forgotten.

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Oct 25 • 12:00 PM EDT • Business • businessinsider.com
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago

"Music is not a matter of life and death, it’s something much more serious than that"

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Oct 25 • 12:00 PM EDT • Entertainment • loudersound.com
In Texas Senate Race, Talarico Leans Into Growing Rivalry With Elon Musk

On the trail, James Talarico, the Democratic Senate nominee, has increasingly gone after Mr. Musk, a critic of his who has given big to a group aligned with the Republican candidate, Ken Paxton.

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Oct 25 • 11:53 AM EDT • Politics • nytimes.com
Obama and Trump wage one last battle for even more urgent stakes

Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.

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Oct 25 • 11:45 AM EDT • Politics • cnn.com
Chivu: “The boys gave everything right to the end”

Cristian Chivu wasn't the only one who couldn't bear to watch Zielinski's decisive penalty. The Inter coach bent over on the touchline, looking away as the midfielder stepped up to take it. When the b...

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
How Braves should handle $42 million Jurickson Profar situation

This could be one solution for the Braves.

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Oct 25 • 11:36 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight

With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
California Politics 360 full episode | Clash over voter rolls heads to court

On Tuesday, one week before the election, a federal judge will determine the next steps.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones

Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.

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Oct 25 • 11:18 AM EDT • Technology • macrumors.com
Rumored Lucia Actress Goes Viral After Dodging Swarm of GTA 6 Comments During Livestream

Manni L. Perez, the actress long rumored to be playing Lucia in GTA 6, has gone viral after dodging a swarm of comments from Grand Theft Auto fans during a recent livestream.

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Oct 25 • 11:14 AM EDT • Technology • ign.com
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known

A "thick and peculiar" cephalopod.

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Oct 25 • 11:00 AM EDT • Science • sciencealert.com
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake

The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.

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Oct 25 • 10:57 AM EDT • Politics • pbs.org
Babcock Singles Out Oiler After Ugly Loss To Maple Leafs.

Mike Babcock called out one player in particular after a 7 - 2 thrashing against the Leafs.

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Oct 25 • 10:43 AM EDT • Sports • sports.yahoo.com
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks

The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.

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Oct 25 • 10:17 AM EDT • Sports • sports.yahoo.com
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026

With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …

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Oct 25 • 10:00 AM EDT • Health • newsdaytonabeach.com
LETTER TO THE EDITOR: Misleading political mailer is a smear campaign

The recent misleading smear mailer by the opponents of Denise Krause in the Oregon Senate campaign is the most disgusting exhibit of money and indecency used to capture uninformed voters’ […]

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Oct 25 • 10:00 AM EDT • Politics • rv-times.com
Science Snapshots: October 25, 2026

Three key science updates in one minute: Starry Night’s dawn matched to Jul 22, 1889; cold boosts lifespan via BH2/BH4; cluster similar-buildings cools cities.

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Oct 25 • 9:40 AM EDT • Science • thehindu.com
Liverpool host Brighton; Man Utd take on Bournemouth in PL

2026-10-25T13:33:41ZA rundown of today's games...2pm kick-offs:Liverpool vs BrightonManchester United vs BournemouthHull City vs BrentfordCrystal Palace vs Newcastle4:30pm kick-off:Sunderland vs Leeds...

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Oct 25 • 9:33 AM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Ranking Ohio State’s remaining games from easiest to hardest

With Julian Sayin out indefinitely, Ohio State’s final five games will define their playoff hopes. Here’s how those opponents rank, from easiest to toughest

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Oct 25 • 9:31 AM EDT • Sports • sports.yahoo.com
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Indiana football should be better. It also could be worse

On one hand, Indiana hasn’t played its best football in weeks. On the other, neither has anyone else, really.

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Oct 25 • 9:06 AM EDT • Sports • sports.yahoo.com
One Underrated Timberwolves Wing Gets High Praise From Chris Finch

Terrence Shannon Jr. is shaping up to be one of the Timberwolves' sneakiest threats.

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Oct 25 • 9:00 AM EDT • Sports • sports.yahoo.com
Will the Brewers lose again this year?

Milwaukee is cooking, y’all. After winning 103 regular season games, they blew through the Padres in the Division Series, swept the Dodgers in 4 games in the Championship Series and currently have a 2-0 lead in the World Series. They’re 5-1 in one-run games, so they’re not exactly blowing teams out. But with their bullpen […]

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Oct 25 • 9:00 AM EDT • Sports • sports.yahoo.com
Business lessons are coming to liberal arts schools

A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.

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Oct 25 • 8:48 AM EDT • Business • npr.org
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AP Business lessons are helping high school students learn how to manage money

A new AP business with personal finance course continues the growth of teaching kids about how to make money and keep it.

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Oct 25 • 8:48 AM EDT • Business • npr.org
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Trump campaigns in Michigan one day after Obama rallied against him

President Donald Trump will campaign for nominee Mike Rogers in Michigan, a day after former President Barack Obama criticized his administration in the state. Follow for live updates.

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Oct 25 • 8:30 AM EDT • Politics • cnn.com
🚨 Barça's squad to face Real Madrid

Barcelona have just announced Hansi Flick's squad for tonight's Clásico against Real Madrid at the Spotify Camp Nou. Midfielder Orian Goren is the standout inclusion in Flick's 23-man squad. Reserve-...

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Oct 25 • 8:26 AM EDT • Sports • sports.yahoo.com
The Leaked Mass Effect 5 Trailer Was Enough To Make Fans Go Feral For One Of Its Sexy, Mysterious Squadmates

We've never had a male Quarian on the team before

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Oct 25 • 8:00 AM EDT • Technology • kotaku.com