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Health problem could delay sentencing for Gov. Newsom's ex-chief of staff
Dana Williamson, a former top political aide to key Democratic leaders in California, including Gov. Newsom, is recovering from what appears to be an unplanned surgery and court records show her attorney is asking a federal court to delay her sentencing.
Legendary ESPN hockey analyst Barry Melrose passes away at 70
The hockey world has been dealt a tragic blow as iconic ESPN hockey analyst Barry Melrose has passed away. ESPN made the announcement on Wednesday evening. Melrose spent a lifetime in hockey as a player, coach, and television analyst. He played over 300 games in the NHL as a defenseman in the 1970s and 1980s.…
Academy Sports (ASO) Rockets 14% on Solid Q2 Despite Consumer Spending Tests
Academy Sports and Outdoors Inc. (NASDAQ:ASO) saw its share price jump by 14.40 percent on Wednesday to close at $51.15 apiece after posting a strong earnings performance in the second quarter of the year despite weakness in consumer spending trends. In an earnings call on the same day, the sporting goods store chain said that […]
Illinois' Zvonimir Ivisic Gets Optimistic Injury Update From Assistant Coach
Illinois basketball's projected backup center got a key update from a Fighting Illini assistant coach.
Helena Foulkes will defeat Rhode Island Gov. Dan McKee, CNN projects, marking a rare incumbent primary loss
Former CVS executive Helena Foulkes will win the Democratic nomination for governor of Rhode Island, CNN’s Decision Desk projects, defeating incumbent Gov. Dan McKee as she capitalized on voter frustration over the partial closure of a key bridge and the ensuing traffic chaos.
Viewpoint: Unlocking Europe’s wildfire data
Europe is already investing in the science, technology and infrastructure needed to understand, prevent and fight wildfires. Copernicus provides satellite-based Earth observation and environmental information, while the European Forest Fire Information System provides information on fire danger and forest fires across Europe. Weather and climate systems add forecasts of heat, drought, wind and humidity; historical fire databases show where fires have occurred; and researchers generate increasingly detailed knowledge about fuels, fire behaviour, forecasting, modelling and risk management. Meanwhile, new European research projects are adding digital twins and other tools to this growing ecosystem.However, these data do not necessarily sit together, nor are they necessarily described, structured or governed in ways that allow them to be used together. Much of the information is public, but some is commercially held. Some is sensitive. Some is subject to legal, security or operational restrictions. Even when data can be legally accessed, different systems may use different formats, terminology and rules.Europe therefore faces an unusual paradox: we have vast amounts of relevant information to respond to the wildfire challenge, but not the means to bring it together. For example, a wildfire researcher or emergency service might need to ask whether a particular combination of vegetation, drought, wind and topography has historically been associated with rapid fire spread. The relevant information may exist in several institutions, using different systems and subject to different conditions of access.The challenge is to conduct an authorised analysis that interacts with these sources, combines the results and respects the rules imposed by each data custodian.An important part of the answer can be found in the Fair principles, the idea that data should be findable, accessible, interoperable and reusable. Developed more than a decade ago, these principles have become a central reference point for modern data stewardship, making it easier for people and machines to find data, understand what it means and determine whether it can be reused.Readability by machines is essential, since AI systems will be key to meeting the data challenge. Bring analysis to the dataThe proposition is not to give an AI system unrestricted access to sensitive databases. Quite the opposite. The goal is to make it possible for approved algorithms to go to the data, rather than requiring sensitive data or large datasets to be copied to wherever the analysis happens.Imagine an analysis asking a series of questions of different data stations. At one station it might examine weather and climate data; at another, historical fire records; at another, experimental measurements of fire behaviour. The algorithm does not need to download everything. It can operate within the environment permitted by each data custodian and return only the results that the rules allow to leave.This is sometimes described as data visiting, and related approaches already exist in areas such as federated analysis and federated learning.Sensitive data should therefore not be treated as a free-for-all for machines. This requires appropriate governance at multiple levels. Access needs to be authenticated and authorised. The purpose of an analysis should be defined. The code or model being run should be controlled. Data custodians should be able to specify what can be queried and what results can leave their environment. Activities should be auditable and human oversight should remain where the consequences require it.In other words, the objective is not to trust AI with the data. It is to design systems in which AI never has more access than it needs.As open as possible, as closed as necessaryFair data should also not be confused with open data. Some wildfire data should be openly available. Other information may legitimately need to remain restricted because it concerns critical infrastructure, security, commercial interests, privacy or operational capabilities. The principle should be: as open as possible, as closed as necessary.The important point is that restricted data should not automatically become unusable data. If machines can discover what information exists, understand its meaning, establish where it came from and determine the conditions under which it can be used, authorised analyses can potentially be carried out without the underlying data ever leaving the environment in which it is protected.Restricted data can still be Fair and machine-actionable.This is also an important question of data sovereignty. European institutions should not have to surrender control of their data to a handful of technology platforms in order to benefit from AI. Nor does Europe need to start again by building one giant repository for every piece of wildfire information. The better approach is to connect what already exists.This is the principle behind emerging approaches such as Tryangle, developed through the Leiden Initiative for Fair and Equitable Science. Rather than creating another centralised data warehouse, the approach seeks to provide an interoperable layer through which approved algorithms can visit distributed data sources while respecting the rules of their custodians.In this way, a data station can remain where it is. Its custodians can retain control. Existing databases and applications do not have to be abandoned. What changes is their ability to communicate with other systems through common, machine-readable descriptions, access rules and interoperability mechanisms.But approaches like this need data that meets the Fair principles. Only then can an interoperable ecosystem safely begin to turn fragmented information into collective intelligence.Data infrastructure is wildfire infrastructureThe implications of this approach are entirely practical. Firefighters could gain better intelligence about local and evolving risks. Land managers could test prevention strategies using more comprehensive information about fuels, weather and past fires. Researchers could compare evidence across ecosystems without repeatedly moving huge datasets between institutions. Smaller regions and resource-constrained teams could access analytical capabilities without having to build large data infrastructures themselves.Europe is already investing heavily in satellites, databases, research programmes, forecasting systems and scientific expertise. The question is whether we will connect those investments well enough to turn them into actionable intelligence.That requires policymakers and funders to treat data infrastructure as seriously as physical infrastructure. Data generated or supported through European public funding should be Fair, verifiable and machine actionable by design, wherever legally and ethically possible.Related articlesData Corner: Europe’s burning need for wildfire mitigation researchClimate monitoring must remain a global enterprise, experts sayIn practice, that means funding not only the production of data, but also the infrastructure that makes data usable across systems: metadata, provenance, interoperability, access mechanisms and governance. Where data must remain restricted, we should ensure that it can still be securely discovered, verified and used for authorised analysis.Initiatives such as the European Open Science Cloud offer an existing framework through which these principles can be put into practice. What is needed now is to accelerate implementation and make them a standard part of how Europe funds and builds research and innovation systems.We do not need another generation of disconnected databases. The data is already there. The opportunity is to make it work together, securely, responsibly and quickly enough to help prevent the next fire, rather than simply document the last one.Jean-Claude Burgelman is professor emeritus at the Free University of Brussels (VUB) and editor-in-chief at Frontiers Policy Lab. For more than 20 years he held leading roles in research and innovation policy at the European Commission.
‘Trump-a-palooza’ aims to energize Republican base
Republicans gathered Wednesday night in Dallas for the first-ever Republican midterm convention, an event designed to energize voters, raise money and highlight key Republican candidates ahead of the November election. CNN’s Alayna Treene takes us through the key moments.
Seahawks' Nick Emmanwori out for Super Bowl rematch against Patriots
The Seahawks will be without a key piece of their defense as they launch their Super Bowl repeat bid against the Patriots.
Church-focused agency rebrands from KingsCover
The agency has saved clients more than $3 million since launching less than a year ago
Data Centers Challenge Our Usual Politics
This year, Harvard Magazine featured an article that asserts that the Democrats have lost key tech industry endorsements. Let’s see if that matters.
Patriots X-factors against the Seahawks in NFL Week 1
Keys to a Patriots win over the Seahawks on Wednesday night.
Writer makes bold prediction regarding Vikings QB Kyler Murray
Kyler Murray could be a top-12 quarterback in a key metric this season.
12-inch water main break impacts several fire hydrants and businesses in Cockeysville
A 12-inch water main break has impacted five fire hydrants and services at several businesses in Cockeysville, Maryland.
Apple just raised prices on new and older iPhones. Here’s what they cost now.
Apple and other gadget makers have raised prices in part because of the shortages of key components in hot demand by AI companies.
Key statistical nuggets for Seahawks’ season opener vs. Patriots
The Seahawks have a great win total playing at home and an impressive point differential from last season on their side heading into Week 1.
Does Kentucky Have Any Chance to Upset Alabama?
Let’s get one thing out of the way. Alabama should beat Kentucky. The Crimson Tide are around 10.5-point favorites , have considerably more talent and looked dominant in their 48-10 Week 1 victory over East Carolina. But does Kentucky have a chance? Absolutely. Make Keelon Russell Look Young This is the biggest key. Keelon Russell…
Spiraea genome reveals how Rosaceae evolved a key defense hormone
A chromosome-level genome of Chinese spiraea reveals how the rose family conserved and remodeled a major route for producing salicylic acid, a hormone central to plant immunity and environmental stress responses.
Scripps, PWHL Ink Media Rights Deal for 2026-27
The agreement is the first season-long TV deal for the women's hockey league.
Patriots News: Week 1 Patriots-Seahawks matchups, keys to victory
Daily news and links for Wednesday, 9/09/26
Lava-Covered Planets Are Defying a Key Rule of Planetary Science
Researchers developed a model showing how lava-covered planets close to their stars can hold onto their atmospheres, which could help guide the search for life beyond our solar system. Some planets orbit so close to their stars that intense radiation should strip away their atmospheres. Yet several of these scorching, lava-covered worlds still retain thick
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
Labor Day rally held in Ellsworth
Uplifting workers was a key focus of Monday's Labor Day rally in Ellsworth, which featured multiple speakers, musicians and a march led by veterans down Main Street.
Sidney Crosby sparks controversy with surprising take on Mike Babcock
The Penguins captain's surprising assessment comes as Edmonton faces fierce backlash over its decision to hire the veteran coach.
Puck Drop Preview: 2026-27 Montreal Canadiens
Last Word On Hockey‘s Puck Drop Previews are back for the 2026-27 season! As the regular season approaches, Last Word will preview each team’s current outlook and stories to watch for the upcoming year. We’ll also do our best to project how things will go for each team throughout the campaign. Today, we’re previewing the 2026-27 …
Winterville man accused of assaulting women with keyboard, officers at ECU Health Medical Center
WITN News At Sunrise 6-7a
John Fetterman, Marjorie Taylor Greene will headline TribFest
Two of American politics’ most unique and least predictable voices bookend our three days of live journalism.
Trump’s Super PAC Is Tied to Mystery Group Spending $25 Million on Midterms
The recently created Republican group is pumping cash into half a dozen key midterm races, with the largest amounts going toward Senate contests in New Hampshire and Alaska.
Apple’s (AAPL) “Surprise and Shine” Event Tests Its Foldable iPhone Against Huawei and Xiaomi
Wall Street sees Apple Inc. (NASDAQ:AAPL) entering a significant hardware cycle ahead of its “Surprise and Shine” event streaming live on Wednesday, September 9, 2026. Bank of America, in particular, expects a broad slate of new Apple devices led by new iPhones and a Foldable iPhone. On September 8, BofA Securities analyst Wamsi Mohan reiterated a […]
Forest penalty v Liverpool incorrect, but not for VAR
Nottingham Forest should not have been awarded a penalty at Liverpool for Alisson's challenge on Neco Williams, the Premier League's Key Match Incidents Panel has said.
‘Smooth World’ filmmaker was surprised that smooth jazz is cruising along
Mickey Duzyj’s documentary has three sneak preview screenings in Atlanta starting this week.
Anthropic AI chief warns of a 'discernment tax' at work
Anthropic's AI fluency chief says knowing when not to use AI is a key skill that can help workers avoid a "discernment tax."
Sphere Entertainment (SPHR) Expands 4D Wizard Of Oz As Valuation Hinges On Growth Story
New 4D effects spotlight Sphere Entertainment’s product ambitions Sphere Entertainment (SPHR) just rolled out an expanded 4D package for The Wizard of Oz at Sphere, adding animatronic Winged Monkeys, themed scents, Glinda Glitter, pyrotechnic fireworks, and scented apples from September 25, 2026. For investors watching Sphere Entertainment, the latest 4D upgrade lands after a choppy few months, with the share price down about 11% over 30 days but still showing strong momentum through a 51%...
Super Bowl rematch to open new season - your guide to NFL's key games
With the 2026 NFL season set to start on Wednesday, here are all the key dates and fixtures on the road to Super Bowl 61.
2004-05 deja-vu - Can Moyes inspire another fine finish?
Deadline day may have left Everton fans feeling disillusioned, but the side is four games into the season and remains unbeaten, nine goals scored, including two in added time to secure a point. After what was a chaotic close to the transfer window, even by the Toffees' own standards, the performance against Manchester United ironically saw the summer signings playing a key role in the fight. Jack Grealish and Hayden Hackney came on from the bench to turn the game on its head, Tyrique George scored to equalise before the visitors went back in front, and it was Ainsley Maitland-Niles with a stunning strike to secure the draw in the final few seconds.
Chubb names digital distribution chief for small commercial
Jennifer Burnham will lead Marketplace and API channel expansion for independent agents
Photos: Fairfield Ludlowe vs. New Canaan high school field hockey
Photos from Tuesday's season-opening Fairfield Ludlowe vs. New Canaan high school field hockey game.
Winterville man accused of assaulting women with keyboard, officers at ECU Health Medical Center
A Winterville man has been arrested after warrants say he assaulted several women and officers at ECU Health Medical Center.
Can the 'best showman in politics' deliver again? GOP bets on Trump at historic midterm convention
Donald Trump headlines the first-ever GOP midterm convention in Dallas, aiming to energize low-propensity MAGA voters ahead of key 2026 races.
Iowa State volleyball swept by Iowa
Iowa State suffered a straight-sets loss to in-state rival Iowa on Tuesday night, falling 25-20, 25-21, 25-23. The Cyclones dropped to 4-2 on the season with the defeat, while the Hawkeyes improved to 4-2. Pam McCune, Mesaiya Bettis, and Nayeli Gonzalez paced the Iowa State attack with eight kills apiece. Alea Goolsby and Nayeli Ti’a […]
SK hynix Charts Its Business and Technology Direction at the 2026 Future Forum—”Now Is the Golden Time to Leap Forward”
▲ SK hynix Vice President Jaewuk Ju, head of the Smart Manufacturing Technology/AX Advance department, delivering the first keynote presentation
West Virginia State Police cadets to begin mental health crisis training September 9
West Virginia State Police cadets will begin Keystone Model crisis training Sept. 9. Classroom lessons and realistic simulations will teach them to recognize behavioral health emergencies, communicate effectively and safely de-escalate encounters.
Detroit Lions Receive Several Major Updates Ahead of Week 1
The Detroit Lions received several major updates ahead of Week 1, including encouraging injury news, a key roster decision, and an intriguing offensive line battle.
Bruins’s Casey Mittelstadt Gets Honest About 1st Year In Boston
It won’t be long now before the Boston Bruins gather for Training Camp in preparation for the 2026-27 NHL Season, and they’ll be out to prove that they’re better than losing in the opening round of the Stanley Cup Playoffs as they did earlier this spring.One of the key forwards for the Bruins is Casey […] The post Bruins’s Casey Mittelstadt Gets Honest About 1st Year In Boston appeared first on HEAVY.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Control of State Senate up for grabs this November
Control of the Wisconsin Senate will hinge on key November races as Democrats seek two seats and Republicans push for a 2027 trifecta.
Colisée’s new owners pledge to ‘bring life back’ to Lewiston’s top entertainment, sports venue
The New York-based owners say the sale signifies a serious future investment in professional hockey in the city, as well as youth hockey, community events and more.
U.S. Department of Health announces key leadership changes at FDA
The U.S. Department of Health and Human Services on Tuesday named four senior leaders at the U.S. Food and Drug Administration, including the heads of its drug center and vaccines and biologics unit.
U.S. Department of Health Announces Key Leadership Changes at FDA
Sept 8 (Reuters) - The U.S. Department of Health and Human Services on Tuesday named four senior leaders at the U.S. Food and Drug Administration, including the heads of its drug center and vaccines and biologics unit. (Reporting by Christy Santhosh in Bengaluru; Editing by Tasim ...
BREAKING: Key Rams Player Is OUT Against The 49ers
Well, so much for seeing Aaron Donald and Myles Garrett together in Week 1. Donald will not travel to Australia with the Rams and has been ruled out for Thursday night’s season opener against the San Francisco 49ers. That’s a major break for Brock Purdy and the 49ers. Donald recently came out of a two-year…
HHS Announces Key Leadership Selections at FDA to Promote Innovation, Reform, and National Health Priorities
The U.S. Department of Health and Human Services today announced the selection of four senior leaders at the U.S. Food and Drug Administration.
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations
The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.
Government land-grab agenda hits key Senate race as Dem backs property takeovers echoing Mamdani
Maine Senate candidate Troy Jackson suggested the state should take over mobile home parks, echoing NYC Mayor Zohran Mamdani's housing agenda.
Scripps Sports Expands Nashville Predators Television Coverage to Seven Additional Markets Across Tennessee, Kentucky and Alabama
Multi-Year Media Rights Agreement Brings Predators Hockey to Broader Regional Audience With Comprehensive Broadcast Package
Bruins Announce Roster, Details for Rookie Camp and Prospects Showcase
The Boston Bruins prospect pool is heading to Buffalo. On Tuesday afternoon, the Bruins announced the roster, schedule, and livestream […]
Business Aims for Tax Breaks in Canada’s Critical Minerals Push
Tax breaks for the mining sector are emerging as a key ask for companies petitioning Canada’s government for help in an upcoming budget.
Jimmy Rolder returns as Lions boast good health ahead of opener
The Detroit Lions roster is fully healthy for practice as key players return ahead of the season opener against Saints.
From science to screen time: 4 key takeaways from the latest PISA results
Amid reading declines that included a 14-point drop for the U.S., researchers are looking at the role digital learning and AI may have played.
Apple Event 2026 Live: The First Foldable iPhone, iPhone 18 Pro, Apple Watch 12 and More
We're counting down to Apple's Sept. 9 unveiling of the foldable iPhone Ultra. It's the first keynote helmed by new Apple CEO John Ternus and expected to be Apple's biggest event in years.
Attack on Titan 3 opening animation key visual revealed
Publisher Koei Tecmo and developer Omega Force have revealed the key visual for the opening animation of the Attack on Titan 3 game, which was created by animation studio MAPPA to celebrate the 17t…
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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New Hampshire voters pick nominees as Sen. Shaheen’s exit sparks a scramble for key seats
New Hampshire primary voters are choosing candidates for Congress, governor and the state Legislature, with the retirement of U.S. Sen. Jeanne Shaheen creating the most competitive races | Talk Radio 1210 WPHT
New Hampshire voters pick nominees as Sen. Shaheen’s exit sparks a scramble for key seats
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