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9 things I learned caddying in a pro qualifier
Looping for a club pro was an eye-opening playing lesson in reverse.
Summer Wellness: Hydration & Gut Health
Supporting gut health doesn’t have to be complicated. Summer is the perfect time to focus on wellness by staying hydrated and choosing fresh, nutrient-rich foods. Adding water-rich fruits and vegetables alongside fiber-rich ingredients can help support digestion, hydration and overall health throughout the season. Demos are FREE to attend but space is limited. For the […]
3 Plant-Based Proteins That Also Boost Gut Health, Per a Dietitian
These protein-rich plant foods also support healthy digestion.
‘Ozempic face’ and hair loss: what evidence is there for weight-loss drug side-effects?
Research into GLP-1 medications is not always robust but complaints such as digestive problems are well known
Lights, Camera, Confidence: Exploring the Representation of Cutaneous Conditions in the Entertainment Industry and Its Impact on Children's Self-esteem
By Richard Moraga, BS, and Peter A. Lio, MD Stigmatization Of Skin Conditions In The Entertainment Industry Representation And Societal Impact of Specific Skin Conditions Missed Opportunities Longitudinal Psychological and Social Effects of Entertainment Influence Changing Perceptions of Skin in Recent Years The Role of Dermatology Call to Action The way that physical appearance […]
4 Common Medications That Can Mess With Your Gut Health
Some medications may disrupt the good bacteria in your gut, potentially affecting your digestive and overall health.
Morning Digest: Lakewood businesses and residents frustrated by constant power outages
Good morning, Cleveland! Here's what you need to know about today's stories on GMC, traffic and weather.
Gut check: What the digestive system means for our overall health
In a Q&A, gastroenterologist Rosemarie Fisher explains common digestive health issues — and the best ways to improve gut health.
Scientists tested 39 sweeteners and found unexpected gut effects
A large laboratory study found that many commonly used sweeteners can directly change the growth of gut bacteria. Researchers identified more than 100 cases in which sweeteners behaved differently when combined with medications, caffeine, or flavorings. The combination of isosteviol and the antidepressant duloxetine was especially disruptive, reducing beneficial bacteria and overall microbial diversity.
These Microbes Removed 96% of Dissolved Uranium From Mine Water
The microbes don't exactly digest uranium, but their metabolism made it far less mobile.
The Rare Pyrex Bowl Produced For Only A Year That Collectors Dream Of Finding At Thrift Stores
Pyrex’s Black Tulip casserole dish is a rare find for thrifters because its pattern of black flowers and pinwheels was only produced from 1956 to 1957.
Skip Pyrex: The Antique Dishware You Can Find At Thrift Stores That's A 'True Collector's Jewel'
The Le Creuset Dutch Oven Terrine is unique. Shaped like a duck and no longer in production, this piece is a rare and interesting twist on plain cookware.
The day I completed golf
On one of my favorite courses, in the gloaming, with a hickory driver, I hit the shot of my life. (Oh, and there's video)
Health officials warn cyclosporiasis spreading to 18 states, with 40 cases in MD, Va.
Health officials warn cyclosporiasis spreading to 18 states
Digesting all the consequences of a weighty Colorado primary election
I arrived home on election night just in time to catch the 10 p.m. news. Flipping to Channel 9 and Kyle Clark, I found him engaged in conversation with a reporter at the Melat Kiros primary victory celebration. The pair expressed surprise at the energetic chants of “Melat!, Melat!” The on-site reporter found the enthusiasm […]
Overnight News Digest: Star Spangled Science Saturday, 7/4/26
Welcome to the Overnight News Digest with a crew consisting of founder Magnifico, regular editors side pocket, maggiejean, Chitown Kev, eeff, Magnifico, annetteboardman, Besame, jck, JeremyBloom…
2026 John Deere Classic tee times, TV coverage, viewer's guide
Tee times, TV coverage and viewer's guide for the John Deere Classic at TPC Deere Run in Silvis, Ill.
6 Ways Your Body Can Change After Starting a High-Protein Diet
Adding more protein to your diet can cause several changes in your body, such as better muscle repair and potential digestive issues.
Four bad habits tournament golf exposed within my game
What one writer learned from his second tournament round of the year.
9 Fruits With the Most Prebiotics For Better Gut Health
Prebiotics are a type of fiber that feeds the good bacteria in your gut, supporting better digestion and overall health. These fruits are a tasty way to get more prebiotics.
Breaking Business News: AbbVie To Acquire Apogee Therapeutics
AbbVie is set to acquire Apogee Therapeutics and its pipeline of multiple clinical-stage candidates in development across inflammatory and immunological diseases, including its lead asset, zumilokibart (APG777), a subcutaneous half-life extended monoclonal antibody targeting interleukin (IL)-13 in atopic dermatitis (AD). Under the terms of the transaction, AbbVie will acquire all outstanding shares of Apogee for $135.11 per share in cash. […]
Kathryn Ann Meinders Digestive Health Institute Now Open, Transforming Oklahoma Healthcare
Digestive healthcare in Oklahoma took a gigantic leap forward Monday with the official grand opening of Mercy’s Kathryn Ann Meinders Digestive Health Institute.
New Mercy digestive health institute aims to change GI care in Oklahoma
In a little over a week, the new Kathryn Ann Meinders Digestive Health Institute will open to patients. Mercy said it’s the only comprehensive GI health care center within a 500-mile drive.
UVM Health is downsizing. Here’s what those cuts mean for services.
Employee unions are still digesting exactly which positions were eliminated at the state’s largest hospital group, but say the losses are certain to influence patient-facing operations.
Advanced Tech on Station Informing Space-Designed Health Treatments
The Expedition 74 crew explored how weightlessness affects cartilage growth and the digestive system on Thursday to protect crew health and improve patient care on Earth. The orbital residents are also gearing up for a robotics maintenance spacewalk at the end of the month on the International Space Station.
Advanced Tech on Station Informing Space-Designed Health Treatments
The Expedition 74 crew explored how weightlessness affects cartilage growth and the digestive system on Thursday to protect crew health and improve patient care on Earth. The orbital residents are also gearing up for a robotics maintenance spacewalk at the end of the month on the International Space Station.
Digestive health coaching program now available; start coaching by July 10 to earn My Wellness points
A new coaching program focused on digestive health is available to Marquette employees and their spouses as part of the My Wellness program.
Can Bankova Muster Political Will to Make Institutional Reforms During War?
Welcome to The Ukraine Compass, a weekly digest of Ukrainian commentary and analysis from across the political spectrum only for War on the Rocks members.
Brooks Koepka dealing with mystery injury heading into U.S. Open
Aead of the U.S. Open at Shinnecock Hills, Brooks Koepka is dealing with a mysterious injury.
The Feed: From Bryson DeChambeau to Justin Thomas, Bob Does Sports continue to land YouTube golf’s biggest fish
A big week for Bob Does Sports, Brad Dalke faces this alma mater and Luke Kwon heads to ... Ohio? The Feed recaps YouTube golf's best videos of the week.
We can create the future of science right now
Paul Litvak is the founder and Executive Director of the Robyn Dawes Institute and a Visiting Scholar at UC Berkeley. He has a PhD in Behavioral Decision Research from Carnegie Mellon where he studied emotions and the sunk cost bias. Over 15 years in industry, he solved a wide range of challenging technical problems. At Meta he created models optimizing the ad review process. At Google he ran experiments to measure social influence. At Airbnb, he was a product manager leading machine learning teams optimizing search ranking and price suggestions. He also co-founded and led product at Rhythmic Health, a venture-backed biosensing startup, creating an accurate low cost system using a color changing strip and a smart phone to measure salivary lactate. The bottleneck At this point, it is uncontroversial to say that science needs to stop using the PDF article as the unit of knowledge and currency. The unbearable slowness of scientific publishing, the profit motive and margins: I’m not saying anything new. The PDF also sucks because it’s hard to extract structured information, which makes it hard to do evidence synthesis. As a result, we do much less evidence synthesis than is needed. And evidence synthesis ultimately undergirds most policy and medical decision-making. I can see second-by-second real-time odds for any sporting or newsworthy event, but a school board can’t see the best evidence on whether their 8th graders should be taught algebra. As a society, we don’t treat this as an important problem. Again, not controversial. Not only is the problem well understood, but the solution has already been laid out. What we need is AI-assisted living evidence synthesis - (1) an open knowledge graph of atomic claims, (2) claims linked to evidence, (3) assessment and synthesis of each piece of evidence, and (4) continuous updating with new data. What few realize (yet) is that the technical capacity to build this vision for a significant portion of science already exists. Not only that, scientists and startup teams are already building many of these components. I know this because I’ve been surveying the space and talking to many of the builders. There are some missing pieces: for example, evaluations of how well some of the components work. But at this point, most of what’s missing is a fully end-to-end working integration of all of these parts. In the rest of this essay, I’m going to lay out all the parts of a working living evidence layer for science and who is working on them, and propose concrete next steps for building this system. What’s now possible The diagram above outlines the components of a living evidence synthesis platform, including some of the teams working on each component1. Scientific PDFs are processed into claims with associated evidence. The evidence is subjected to a forensic audit, methodological evaluation and robustness and reproducibility checks. Finally it’s given a weight in a continuously updating synthesis. What follows is a description and status of each component and a few of the teams working on them. Document understanding The first thing you need to be able to do is turn an article into structured data. Mostly that means parsing PDFs. There are often multicolumn layouts that confuse non-specialized PDF to text processing libraries. For scientific papers, there is the added complexity of parsing formulas and tables and figures. This is a really hot area - there are startups offering APIs, and it seems like a new open source package gets posted to Github every few weeks. What follows isn’t exhaustive. A package called GROBID was the state of the art for a while, they didn’t update their package for nearly two years until very recently. In the meantime reducto.ai released an AI powered PDF extraction API, PaddleOCR became popular, IBM released a model called Docling, and both Mistral and Gemini created models and libraries. I also know of at least one other well-funded psychology research group working on a paper parser. By contrast, there are few open evals in this space, with no extensive evals for complex table comprehension in particular. Nonetheless, I’m confident this will be a solved problem soon, given the combination of LLM advances and developer interest. Hypothesis level extraction There has been increasing interest in comprehending the extracted text of papers and linking information to evidence for each hypothesis. A lot of work has already been done. Trialstreamer (Marshall et al. 2020) and RobotReviewer LIVE (Marshall et al. 2023) demonstrated automated extraction of trial population, intervention, and outcome at scale on clinical RCTs. PaperQA2 (Skarlinski et al. 2024) and Ai2 ScholarQA (2024) extended this to retrieval-augmented question answering with citation grounding. Elicit, Consensus, and SciSpace operationalized claim-level extraction for end users. OpenEval (Booeshaghi et al. 2026) is the most recent and most ambitious: 1.96 million atomic claims extracted from 16,087 eLife manuscripts using Claude Sonnet 4.5, grouped into ~299,000 results, with LLM evaluations showing 81% agreement with human peer review on a 2,487-paper subset. None of these solutions link claims to test-statistics, as you would need to evaluate randomized controlled trials. This is why I built the evidence.guide API - to extract hypotheses and associated test statistics from behavioral science papers. The best public eval of this kind of extraction I’m aware of comes from the recent SCORE project - they had humans code thousands of psychology papers to extract their claims by hand. It would be extremely helpful to the world if all scientific PDFs were available as structured open data. I’ve been working to make this happen, both directly at Berkeley and through coordination with large entities I can’t yet speak of; as hard as it is to do, I think it’s possible2. Forensic audit A lot of work has been done on forensic audit, but some gaps remain. Of course, for biology papers that rely on images for evidence, there are a variety of tools (notably Proofig and ImageTwin) to spot anomalies. These are still well short of what sleuths like Elizabeth Bik can do on her own, but these tools are constant companions among fraud analysts. There’s someone working on auditing Excel files for anomalies, and a number of teams are automating numerical checks like GRIM and SPRITE, including Scrutiny project, the INSPECT-SR team as well as statcheck. The regcheck team is building a way to use AI to compare preregistrations to analyses in papers, to ensure there aren’t significant deviations. Nonetheless, there are many other kinds of anomalies to screen for, both public and less publicly known. And there are no formal evals for anomaly detection that I’m aware of. Still, there’s a lot to draw from in this space and I’m pretty certain we will be able to scan papers for most kinds of obvious anomalies in the near future. Methodological review This area has been white hot, though I fear for many of the startups in this space, because this capability may become commoditized. There are at least six different AI peer review companies, including Refine.ink, Reviewer3, ReviewerZero.ai, Q.E.D. Science, Paper Wizard, and Isitcredible. Coarse (a pun on refine) was also recently created as an open source alternative. These systems provide qualitative feedback on the content of papers, spotting methodological weaknesses and mathematical errors. They seem to work pretty well, and many academics report bitterly that they exceed the average quality of typical peer reviewers. But there are few evals here either. What evals exist so far involve using LLM-as-judge (circularity problems abound) or comparing against human reviews of questionable quality. What you’d ideally want is an eval that measures capturing known errors in papers3. Reproducibility and robustness Another active area has been using AI agents to automate computational reproducibility4 and robustness5 checks in papers that report numerical results. For more recent papers where data and code are available, AI agents can see whether they can re-run the analyses and produce the numbers reported in the published paper. In addition to a handful of individual academics who have been experimenting using Claude Code for this, the Institute for Replication is a leading group working on building an end to end system. The evals related to this problem are the most mature, with CORE-Bench (Siegel, Kapoor, Narayanan 2024) and PaperBench (OpenAI 2025) available to benchmark agents on this task. There is also work on getting AI agents to test alternative ways of analyzing the data to ensure the results are robust to small analytic design choices. Synthesis This is the most underdeveloped area where significant investment is required. Although some automated evidence synthesis systems exist — for example, otto-sr is building an AI agent to write systematic reviews — none of these incorporate the full range of paper level signals to weight evidence appropriately. Nor is there anything like an eval or a gold standard for a good systematic review. Arguably Cochrane reviews are the closest we have to gold standard human systematic reviews, though I’ve heard academics in the know complain about their uneven quality. A key question for a synthesis platform is how to weight anomalies and methodological issues in assessing the quality of a piece of evidence. This is an unsolved problem and one I’m very keen to work on. Continuous updating There are many pieces of basic infrastructure available for monitoring for new research and initiating updates. OpenAlex is the current open citation graph. Retraction Watch integrated into Crossref in October 2023. Scite tracks how citations support, contrast, or mention prior claims. The Living Evidence Network demonstrated continuous-update workflows in clinical guidelines. Engineering this is a relatively straightforward task. When you look over this technical architecture and all the progress being made, it’s hard not to be optimistic that a living guide to scientific evidence will be built. The stakeholders are ready The social infrastructure for this is starting to coalesce — it’s not just a pie in the sky academic exercise to imagine this coming into existence. Institutions like the Center for Open Science, the Institute for Replication, the INSPECT-SR, the Living Evidence Network and more are all working on scaling work to improve research quality. Funders are also aligned. The Sloan Foundation has funded living evidence work through COS. Coefficient Giving supports the Institute for Replication and COS. The Astera Institute and the Institute for Progress have shown interest in this space. NIH has established an Office for Replication and Reproducibility. Although there are (very unfortunately) serious headwinds in science funding generally, there is an active group of funders interested in metascience. A brief word about what I’ve been doing at RDI. First, as a Visiting Scholar at Berkeley I’ve been actively figuring out how a non-profit and a public university can conduct and make public the results of large-scale academic article data mining. With some of the money I raised from donors, I commissioned a legal analysis of recent case law and publisher text data mining (TDM) agreements in order to understand whether a massive open data mining of academic articles is possible (with caveats, it is). I’ve also been working to bring together stakeholders in this space, and identify gaps. I’ve also been doing some software development in this space, with more to come. A pilot proposal The assumption undergirding all of this is that an AI, given all this information, would make the right judgment about a scientific claim with lots of conflicting evidence, weighing all the factors appropriately. That’s the hypothesis we need to test. Randomized control trial research is the best place to focus on first. RCTs are used to make many of the important decisions in society - from medical trials to public policy changes. And they use a relatively uniform set of inferential statistics with lots of known and available diagnostics. Behavioral science experiments, within the broader realm of RCTs, should be first used as a testbed whose results can be generalized. Because behavioral science is at the vanguard of open science practices, replications abound (there are thousands of them) to serve as ground truth training data. Key Hypothesis Therefore the pilot would test, in behavioral RCTs that have been replicated, whether the quality of evidence for a claim can be used to accurately predict whether that claim will replicate. Secondary Hypotheses Compared to claims that replicated, non-replicated claims demonstrate a greater share of forensic anomalies in their source literatures. Hypothesis level claim and statistic extraction is accurate enough to scale living evidence without onerous human review costs. Replication prediction is more accurate than prediction markets6 or journal prestige. If all the different quality signals we gather do accurately predict which studies will replicate, then we can use that model to score evidence to power the living evidence layer. Why this is informative regardless of outcome If the pilot succeeds, the architecture extends to medical RCTs (where Living Evidence already operates and integration is mostly about claim representation), then to slices of basic biology with stable replication structure. If it fails, the field learns which quality signals are load-bearing and which ones metascience has oversold. Either result is a contribution to knowing what the literature supports. Implications for funders Because this burgeoning ecosystem of builders already exists, a well-informed philanthropic or government funder could play a crucial catalyzing role in bringing this future about. They could play at least three roles: creating open structured datasets, publishing open benchmarks and incentivizing the solving of key technical challenges. First, open archives of papers that the government maintains, like PubMed, could be turned into structured data amenable to large scale metascience and claim aggregation. I know the US government already has an interest in doing this, though some key open questions remain unanswered. How do you determine the best models and systems for accurately extracting information from papers? How can you establish a robust way to allow researchers to flag errors and correct them? And finally, how do you create a legal regime in working with publishers to maximize the scope of available papers? For the latter, a university or a private philanthropy may be better positioned to make structured data publicly available under journal subscription terms or fair use. Philanthropists or government funders could also coordinate to create or commission benchmarks that evaluate whether important problems have been solved. For example, an open benchmark for claim extraction from a range of different scientific article types would be extremely helpful. Ensuring the underlying data are accurate is vital for creating these evaluations. I’ve discussed opportunistically using various human-created datasets for this purpose, but a consistent problem is that errors in human data make it difficult for them to serve as a gold standard. Finally, with structured data and benchmarks available, the government or private philanthropy could use them to incentivize groups to develop machine learning systems that meet these benchmarks. Prizes are one potentially valuable tool for this. For example, you could establish a prize for a system that accurately updates a living meta-analysis for a small set of claims. Prizes are particularly useful as signals of problem importance, and can help create vibrant ecosystems of public and private research—see, for example the role the government played in kickstarting the current work on nuclear fusion. Conclusion The drawbacks of the current scientific publishing system are known. Scientists agree, metascientists agree, philanthropists agree: the published PDF plus citation graph isn’t the right substrate for maintaining a representation of the evidence base in science. The pieces needed to build the alternative either already exist or are rapidly taking shape. The community is forming around exactly this problem, with concrete partnerships and shared infrastructure. A pilot should start on behavioral science RCTs because that’s the slice of empirical science most amenable to legibility, where replication ground truth is richest, and where the failure modes are best documented. What’s been missing is the galvanizing mission to assemble these pieces into something that works. That’s what I’m proposing to build. *** 1 I have a broader field map that I’ll release publicly soon. This is me, building in public! 2 If this is something that you are excited about, please reach out and talk to me. 3 More on this very soon too! 4 This tests whether, given the code and the data, you can get the same statistics as reported in the published paper. 5 This tests whether the results are the same as a paper’s given alternative analytical decisions in conducting the analysis (like outlier omission). Closely related is the idea of a “multiverse” where you come up with many different ways of answering the same underlying research question with the same data, and test whether the results hold in all those alternative methods. There’s been work on the latter as well. 6 Some of the replications, e.g. those from the SCORE project, had paired the experiments with forecasts from prediction markets. So we get to look at this for free.
If stress is wreaking havoc on your gut, late-night snacking may make it worse
Eating late at night may compound the harmful impacts of stress on your digestive health and gut microbiome, according to recent research.
Overnight News Digest: Science Saturday, 6/6/26
Welcome to the Overnight News Digest with a crew consisting of founder Magnifico, regular editors side pocket, maggiejean, Chitown Kev, eeff, Magnifico, annetteboardman, Besame, jck, JeremyBloom…
AD PRO’s Grow Your Business Month
This July, AD PRO is gathering industry thought-leaders to discuss the best business practices propelling firms today
Last Call for 6.4.26 – A prime-time read of what’s going down in Florida
A digest of the day's politics and policy while the bartender refreshes your drink.
Last Call for 6.3.26 – A prime-time read of what’s going down in Florida
A digest of the day's politics and policy while the bartender refreshes your drink.
South African rand slips on renewed Gulf hostilities, sour business PMI
The South African rand weakened in early trading on Wednesday as renewed tensions in the Gulf rattled sentiment after U.S.-Iran talks stalled, while domestic investors also digested a business survey pointing to a contraction in activity.
Overnight Science Saturday News Digest May 30th, 2026
Grapefruit-sized hail may become more common in a warmer world New 3D silicon chip breakthrough could extend Moore’s Law for years | ScienceDaily Ancient DNA reveals how women helped transform…
An important exception to a common course strategy rule
A recent mistake underscored that the smart play and the right play can differ.
Last Call for 5.27.26 – A prime-time read of what’s going down in Florida
A digest of the day's politics and policy while the bartender refreshes your drink.
Advancing CAR-T Cell Science in Lupus: Meet the First Recipients of the Lupus Research Alliance–Genentech Fund
The inaugural recipients of the Lupus Research Alliance (LRA)– Genentech Award on Immune Resetting Therapies for Lupus (LGA-IRT) are… Anne Davidson, MBBS, The Feinstein Institutes for Medical Research Chimeric antigen receptor (CAR)-T cell therapy can lead to long-lasting remission in lupus, but it is not yet clear how it works at a cellular level or […]
World Digestive Health Day: Habits to Keep Your Gut Healthy
Key Takeaways:Daily habits such as drinking water and eating fiber are key to gut health.Ultra-processed foods may cause inflammation and digestive problems over time.Short walks after meals can improve digestion, and ongoing symptoms shouldn’t be ignored.
Overnight Science Digest: Our ‘mere presence in a landscape’ affects wildlife behaviors
When Humans Went Away, the Wildlife Strayed – NY Times Massive butterfly swarm becomes the talk of Santa Cruz – SF Gate Scientists reversed memory loss by recharging the brain’s tiny engines – Science…
Sterling steady but weak business activity data weighs
The pound was steady against the dollar on Thursday as broader currency markets focused on developments in the Iran war, while traders digested some worse-than-expected surveys of British business activity.
Scientists Discovered A Population Developed a Genetic Superpower—Thanks to Potatoes
A new DNA study found that Peruvian Andeans possess a high number of salivary amylase genes, or AMY1, for digesting starchy foods like the native potato.
'A hidden blood pump': How chewing more boosts your brain
While it's widely known that chewing more improves digestion, research suggests it can also boost our brains and even help fend off Alzheimer's.
Humans in The Andes Have Evolved a Strange Digestive Superpower
Boil 'em, mash 'em, stick 'em in a stew...
Humans in The Andes Have Evolved a Strange Digestive Superpower
Boil 'em, mash 'em, stick 'em in a stew...
Business Briefs for Saturday, May 16, 2026
This week's digest of area business announcements, milestones and news.
Scientists discover tiny gut particles that may drive aging and chronic disease
A new study suggests microscopic particles from the gut may actively drive inflammation and chronic diseases associated with aging. Remarkably, gut particles from young animals appeared to counter some aging-related damage in older animals, hinting at new possibilities for future treatments.
You should probably eat more fiber. Here's why — and how to do it
The average person eats 10-15 grams of fiber per day, according to the USDA. The problem? That’s WAY under the recommended daily amount. Fiber – a type of carb that our bodies are unable to digest – is prevalent in foods like fruits, veggies, whole grains, and beans. And it’s key for everything from feelings of fullness, to gut health, to good poop. That’s why a lot of people online are “fibermaxxing”: trying to meet or exceed the daily recommendation of fiber, in hopes it’ll improve their health. But how should YOU add fiber to your diet… and are the fibermaxxers overdoing it? Gastroenterologist Berkeley Limketkai is here to help parse the science on how little fiber is too little, how much fiber is too much – and, like Goldilocks, how we can figure out the amount that’s just right.Interested in more food and dietary science? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Alignment Healthcare (ALHC) Climbs 7% Ahead of Business Updates
Alignment Healthcare Inc. (NASDAQ:ALHC) is one of the 10 Stocks With Stunning Gains. Alignment Healthcare bounced back by 7.11 percent on Tuesday to finish at $18.38 apiece, as investors positioned portfolios ahead of business updates from its participation in a health conference this week, while digesting changes in its leadership composition. In a notice on […]
How to limit your "I'm such an idiot" moments
In golf, the worst mistakes are the most avoidable kind.
Black licorice compound shows promise against inflammatory bowel disease
Researchers have developed a stem cell-based model of the human intestine that may transform how new IBD treatments are discovered. After testing thousands of compounds, they identified glycyrrhizin — a natural substance found in black licorice — as a promising anti-inflammatory candidate. In both lab-grown tissue and mice, the compound reduced intestinal damage and cell death linked to IBD.
2026 Truist Championship tee times, TV coverage, viewer's guide
Tee times, TV coverage and viewer's guide for the Truist Championship at Quail Hollow Club in Charlotte, N.C.
SecureFood School: Transforming Food System Risk Science into Real-World Education
Strengthening food system resilience requires not only technological innovation, but also an improved societal understanding of food system dynamics and risks.
Iterative Health Reports Expanded Trial Performance Data at Digestive Disease Week 2026, Demonstrating Consistent Outperformance of Industry Benchmarks at Double the Scale
CAMBRIDGE, Mass., May 04, 2026--Iterative Health announced the presentation of updated scientific research at Digestive Disease Week (DDW) 2026.
Popular science
Isaiah Keys has beaten the odds, and is asking for help with keeping him on a winning streak. Keys, Warren High School freshman, could be the next student to tour The Planetary Society in California with Bill Nye The Science Guy, as well as appear in Reader’s Digest and receive $20,000 to invest in his […]
UT Health San Antonio researchers awarded grant to study how circadian rhythm disruptions may contribute to Alzheimer’s - UT Health San Antonio
Environmental stressors like jet lag, high-fat foods suspected as disease risk Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, April 27, 2026 – Can jet lag cause more than just sleep loss? Do quick-grab, high-fat foods associated with late-night or rotating work shifts bring more than indigestion? Those circadian […]
Overnight Science Digest: Rethinking thinking by examining animal and AI intelligences
This week’s science news theme—the convoluted relationships between humans and non-human intelligences—arose from an unexpected combination of two dichotomous groups, wildlife and AI. I’ve added in a…
Is Elon Musk building the AI Avengers?
As the internet digests the SpaceX-Cursor deal, we've got the scoop on another startup Musk explored a partnership with.
Speaker series makes science digestible for all audiences
The Center for Communicating Science created a recipe to help bridge the gap between science research and the public through its Science on Tap series.
Last Call for 4.16.26 – A prime-time read of what’s going down in Florida
A digest of the day's politics and policy while the bartender refreshes your drink.
The gut health benefits of everyday herbs
Discover how everyday herbs support gut health, digestion, and overall wellness while adding flavor to simple, everyday meals.
Goodbye Traditional Bathtubs & Showers – There's A New Trend Taking Over
Technology has made its way into the smallest of spaces in our homes, including the bathroom. There's one smart tech feature in particular that's trending.
If you aren’t losing weight with GLP-1 drugs, this may be one reason why
Two genes involved in gut hormones that influence appetite and digestion may be a factor in how people respond to GLP-1 drugs, according to a new study.
What Is Tmrw Longevity Powder? Here's what to know about the blue scoop
Tmrw Longevity Powder combines blue spirulina with a focused blend designed to support energy, clarity, digestion and healthy aging pathways.
Last Call for 4.7.26 – A prime-time read of what’s going down in Florida
A digest of the day's politics and policy while the bartender refreshes your drink.
Breeding Digest: Gun Runner Meaning Business
GI Santa Anita Oaks winner Meaning (Gun Runner) was part of a big weekend for her sire and is one of the favorites for Kentucky Oaks
MAGA Is Winning Its War Against U.S. Science
Source: NBER With all the other terrible news right now, you may not have noticed that Donald Trump is in the process of killing American science. OK, that’s an exaggeration — but not that much of an exaggeration. The Trump administration’s latest budget proposal calls for a gigantic increase in military spending combined with severe cuts to social programs. But as the chart above shows, it also calls for debilitating reductions in research funding. Furthermore, Trump appointees have already been strangling science by sharply reducing the rate at which research grants are approved. Here, for example, is the number of new grants approved by the National Science Foundation: Source: Nature Large numbers of existing grants have also been frozen or terminated, especially in the study of infectious diseases. Add to this a sharp drop in visas issued to foreign students, who often play a direct role in research and who help support academic departments that do research: Put all of this together, and much U.S. scientific research is set to come to a screeching halt — not a few years from now, but over the course of the next year or two. This new assault on U.S. science is taking place at a time when the role of American science in the world has already been greatly eroded. The chart below, based on research recently reported by the National Bureau of Economic Research, measures national strength in science by the share of publications in highly ranked journals. In the 1990s the United States had more such publications than the rest of the world combined. Since then we’ve dropped into third place — well behind China and slightly below the European Union. And this was before the Trump administration’s attack on science had time to take its full effect. Source Some erosion in U.S. scientific preeminence was inevitable given China’s growing sophistication and wealth. But we’ve also fallen behind Europe, even though everyone says that Europe is lagging economically and technologically. Claims about Europe’s underperformance are, in fact, dubious if one looks hard at the data. But it’s still striking to see America lagging. What’s going on? There are presumably multiple factors behind America’s scientific lag. But even before Trump II the growing hostility of the U.S. right to science surely had some negative effect. And since the rise of MAGA G.O.P. attitudes toward science in general have become overwhelmingly hostile. This is true even for the Republican rank and file: And while I haven’t been able to find good survey data, it’s obvious that the anti-science turn has been even more pronounced — and began earlier — among the Republican political elite. Chris Mooney published The Republican War on Science in 2005, and even then was describing a longstanding trend. Why have Republicans turned so anti-science? Part of the answer is that they believe that scientists don’t support them. And they’re right! A study of who scientists give money to shows that only a small percentage gave money to Republicans even 20 years ago, and that almost none of them donate to Republicans now: Social scientists have always been strongly pro-Democratic, while there used to be a significant number of physical, “hard” scientists supporting the GOP. But these days physicists are almost as uniformly Democratic, or at least non-Republican, as sociologists. Why are there almost no Republican scientists? It’s not a mystery. GOP political orthodoxy includes positions that are at odds with the scientific consensus on multiple issues, ranging from the validity of the theory of evolution, to the reality of climate change, to the efficacy and safety of vaccines. In each case the scientific consensus is solidly grounded in evidence. But even before the rise of MAGA the U.S. right was increasingly hostile to evidence-based policymaking — especially, of course, where the evidence is unfavorable to fossil fuel interests or quack medicine, both financial mainstays of right-wing politics. So scientists don’t support Republicans, and the feeling is mutual. Today’s Republican Party doesn’t like science or scientists. It doesn’t like having its preconceived views challenged by appeals to evidence. It knows that very few scientists are on its side electorally. In general, it sees scientific research as a threat to its grasp on political power. Add in MAGA’s combination of rabid anti-intellectualism and allergy to any hint of criticism, and one has the makings of a drastic anti-science turn in policy. “Ignorance is strength” might was well be an official MAGA motto. And as I said, we aren’t talking about something that will happen over the course of multiple years: The U.S. scientific enterprise is threatened with severe damage, even collapse, over just the next year. There are many reasons to find this prospect horrifying: Think of all the beneficial advances, affecting almost every part of life, that won’t happen because U.S. science — still crucial to the world — has been eviscerated. But think, also, of America’s international standing. Can a nation that has forfeited its role as a leader, or even a contender, in global science, still be a Great Power? No. MUSICAL CODA
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Last Call for 4.2.26 – A prime-time read of what’s going down in Florida
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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