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The Political Calculus Behind Newsom’s Opposition to California’s Billionaire Tax
As the governor weighs a presidential run, is he also looking ahead to how it might play nationally?
Bill Nye ‘The Science Guy’ coming to Bellingham next month. How to get tickets
The show is one night only at Mount Baker Theatre.
Opinion | How will Mass. face its health care crisis?
Up to 300,000 people could eventually lose coverage under Trump’s One Big Beautiful Bill
Opinion: As Illinois patients struggle to afford care, hospitals profit
A little-known program allows hospitals to purchase drugs for as little as a penny and then resell them for thousands, inflating Illinoisans’ pharmacy bills and insurance premiums.
Hartford Q3 profit rises 23% while core earnings decline
The Hartford on Monday reported third-quarter net income available to common stockholders of $1.32 billion, up 23% from the same period last year, as results included a $497 million pretax gain from…
James Webb telescope discovers most distant ring galaxy ever, hinting at an ultra-rare early universe collision
Astronomers using the James Webb Space Telescope have observed a galaxy with a ring of newborn stars as it appeared 2.1 billion years after the Big Bang — hinting that the early universe may have been more chaotic than once thought.
Baltimore Ravens Hit With Clear Warning Before Taking on Buffalo
The Baltimore Ravens are facing an extremely important game this week against the Bills.
Big Fix: Money in Politics
We discuss how dark money shapes policy, how to curb pay-to-play corruption, and how to limit the influence of billionaire donors.
Gina Hinojosa wins court order to review Abbott-Musk emails, Gov. Abbott appeals
A judge has ordered the governor to let his Democratic opponent inspect unredacted communications with billionaire Elon Musk.
Skydance Offers Buyouts Amid Paramount Merger Layoff Fears
Skydance offers employee buyouts and mandates five-day office work as the $110 billion Paramount-Warner Bros. merger raises layoff fears.
Conglomerate faces nearly $1B asset freeze amid fraud probe
Cambodian authorities have frozen almost $1 billion in assets linked to Phnom Penh-based Prince Group plc amid investigations into technology-based fraud and money laundering…
U.S. Small Business Administration Names SBA Lafayette an SBA Preferred Lender
Lafayette Square SBLC, LLC (doing business as SBA Lafayette), today announced being named a Preferred Lender ("PLP") by the U.S. Small Business Administration ("the SBA"). The designation gives SBA Lafayette delegated authority to make SBA 7(a) credit decisions, expediting funding approval. In fiscal year 2025, the SBA backed 77,600 7(a) loans totaling $37 billion, making the program a vital source of capital to American small businesses.
State employees, retirees blew through $1.3 billion in healthcare costs, ended year in deficit
Read More at Inside Investigator >>
New IU medical campus enters final stretch of construction
Four years after breaking ground, the $4.74 billion Indiana University Health Medical Center campus in downtown Indianapolis has entered its last stages of construction. Portions of the hospital building are nearing completion, with some floors starting to be stocked with furniture and equipment.
SheMed Built a $1 Billion Business on GLP-1s. Its Next Bet Goes Beyond Weight Loss
SheMed’s study of more than 8,000 women found improvements in weight, blood sugar, and cholesterol. Its founders believe that’s just the start of what GLP-1 research could uncover.
Richmond’s beloved Valhalla Rising Bakery to close due to owner’s health struggles
The baker of Billy Bread will close Valhalla Rising Bakery in Richmond on Saturday due to ongoing health struggles.
Atlanta business owner's $30,000 water bill dispute helped inspire new city legislation
Inside the new donor class shaping San Francisco politics
Billionaires, AI companies and a new donor class are pouring millions into San Francisco’s election, from Mayor Lurie’s charter push to the race for Pelosi’s seat.
Inside the new NYU Langone CEO’s plans for growth
NYU Langone is planning to build a multibillion-dollar academic medical center on Long Island.
Transmission Lines Could Have Cut Through the Ranch of a Billionaire Abbott Donor. Then Planners Made Them Go Away.
As hundreds of landowners fought to keep towers off their land, Kelcy Warren saw wholesale relief—without filing an official protest.
Global cyberscams bilk Americans out of billions. A fragmented US response means few get money back
A U.S. congressional investigation has found that the U.S. government’s response to surging cyberscams remains fragmented and leaves victims struggling to recover losses
High power bills, blackouts land Michigan utilities on the ballot
A ballot measure could test the limits of how states can curb corporate influence in politics.
Medical debt hit 1 in 4 Americans and 1 in 5 Ohioans last year, even the insured, study shows
Medical debt hit 1 in 4 Americans and 1 in 5 Ohioans last year, a new study shows, including those who have health insurance.
HSBC to hand billions to shareholders as profits surge 32%
Rolling coverage of the latest economic and financial news
Anthropic’s S-1, by the numbers: A thriving business—with a $441 billion asterisk
Anthropic's business is booming. But so are its commitments.
An AI startup wants to build your digital consumer twin
Simile raised $300 million at a $2 billion valuation to build AI digital doubles that predict how shoppers might react to products and marketing.
Skydance offers voluntary buyouts, mandates five-day office week after $110 billion Warner Bros Discovery deal
The media giant is looking to rein in costs and manage an estimated $80 billion debt burden as it integrates Warner Bros Discovery and prepares to outline its strategy to investors.
Lakers Rule Out 2 Players Ahead of Trail Blazers Matchup
The Lakers are trying to keep their winning streak going against the Trail Blazers, and they will have a relatively clean bill of health. The post Lakers Rule Out 2 Players Ahead of Trail Blazers Matchup appeared first on LA Sports Report.
Opinion | Everything is political, even if you aren’t
It is easy to feel disconnected from politics. Most of us will never set foot behind the closed doors in Washington D.C., so from a distance, politics seems like something irrelevant to ordinary citizens. That distance can make disengagement seem appealing. With another candidate, election, or bill constantly dominating the news, taking an apolitical stance...
JYP Entertainment soars 10% on reports of tender offer plan to buy up to half of firm
South Korean pop music agency JYP Entertainment's KRX:035900 shares jumped 10% on Tuesday after Korean media reported Japan's Nexroc Group and related firm SVCV Inc were planning to announce a tender offer to buy up to a 50% stake in the company.The 50% stake is worth about 700 billion won ($528.04…
JYP Entertainment shares rally on report of tender offer to buy up to 50% stake
South Korean pop music agency JYP Entertainment's KRX:035900 shares rallied on Tuesday, jumping 10% after Korean media reported Japan's Nexroc Group and SVCV Inc were planning to announce a tender offer to buy up to a 50% stake in the company.The 50% stake is worth about 700 billion won ($528.04 mi…
Skydance offers voluntary buyouts to some employees
Skydance Corp. is offering some employees a one-time voluntary buyout, a move that comes nearly three weeks after Paramount Skydance closed its $111 billion acquisition of Warner Bros. Discovery. The
Smithsonian scientists just recreated the first 2 billion years of the Universe
Scientists have created one of the largest and most detailed simulations of the early universe ever made, offering an extraordinary new glimpse into the cosmos shortly after the Big Bang. Called Lumina, the groundbreaking simulation recreates the universe’s first 2 billion years, showing how dark matter, gas, and radiation interacted to give rise to the earliest stars, galaxies, and black holes.
Bob Woodward Criticizes Jeff Bezos in New Memoir
Six takeaways from a new memoir by Mr. Woodward, the star Washington Post reporter, including his disappointment with the newspaper’s billionaire owner.
Anthropic IPO filing reveals AI profits and $800 billion compute risk
Anthropic's IPO filing shows AI can be profitable at scale. Nearly $800 billion in computing deals pose a major risk.
Billy Evans' 'You Can See Everything' shower scene was his idea
Billy Evans — the partner of Theranos founder Elizabeth Holmes — asked the 'You Can See Everything' team: 'Want to film me showering?'
St. Joseph County shops warn of fake $50s after business owner loses money on deposit
Businesses in St. Joseph County are reporting counterfeit $50 bills, with one local business owner speaking out to warn others after discovering a bill she rece
Nonprofit Bon Secours Mercy Health strikes $5.7 billion deal for surgery center chain
The deal would make the Catholic system one of the largest operators of outpatient surgery centers.
Billy Evans suggested the shower scene in 'You Can See Everything'
"You Can See Everything" director Lance Oppenheim said that Elizabeth Holmes' partner, Billy Evans, suggested he be filmed in the shower.
Pennsylvania House passes bill requiring AI disclosure in healthcare
If enacted, the legislation would require healthcare facilities, including imaging centers, to disclose their use of AI in clinical decision-making through website postings and written patient notifications, among other things.
Mass Effect fans ramp up efforts to save BioWare's RPG series with a Times Square billboard and plans for more ads outside The Game Awards
Fans are organising to support the "Save Mass Effect" movement with a billboard in Times Square, and more high-visibility ads planned for the rest of the year.
MTSU recognized by Billboard among top music business schools for 12th year in a row
Billboard magazine names MTSU in its unranked annual report.
New IU medical campus enters final stretch of construction
Four years after breaking ground, the $4.74 billion Indiana University Health Medical Center campus in downtown Indianapolis has entered its last stages of construction.
Billy Corgan says 25-year age gap with wife was ‘an advantage’ because she wasn’t ‘wounded’ like older women
The couple met in 2012, when Corgan was 44 and Chloé Mendel was 19.
The Fans Trying To Save Mass Effect Just Paid For A Billboard In Times Square
The group’s petition to keep BioWare’s series alive just surpassed 200,000 signatures
jump.global on Layoffs & the 'Business of Your First and Last Name'
jump.global's CEO on layoffs and the "business of your first and last name."
Patriots reportedly cut one of Bill Belichick's final draft picks
The Patriots are reportedly releasing former starting punter Bryce Baringer.
Bon Secours Mercy Health to acquire majority stake in Surgery Partners in $5.7B deal
Bon Secours Mercy Health is acquiring a majority share in healthcare services company Surgery Partners in a take-private deal valuing the acquiree at $5.7 billion, the organizations announced Monda | The pending deal values the short-stay surgical platform at $5.7 billion, and is the latest example of large health systems' push to build out their ambulatory networks.
Audi Builds in Georgia, and the Politics Come With It
The German luxury brand plans a $4 billion US factory to escape punishing import tariffs, but its CEO’s appearance alongside Donald Trump has turned a strategic manufacturing decision into a governance headache back home.
Canadian retail giant targets Issa brothers' petrol stations business
Quebec-based Alimentation Couche-Tard tables $8 billion bid for Cumberland Farms
Bon Secours Mercy Health affiliate will buy Surgery Partners for about $5.7 billion
Surgery Partners shareholders other than Bain Capital would receive $23.50 a share in cash; the deal is expected to close in early 2027
First 2 billion years of universe's existence revealed in mind-blowing simulation: 'Exciting new frontier'
They're bringing the Big Bang Theory to life.
Meta Plans To Raise Up To $95 Billion In Equity To Power AI
Meta stock was lower premarket after the tech giant announced plans to raise $95 billion in equity.
Georgia’s Audi megadeal comes with political flashbacks
With Election Day nearing, President Donald Trump unveiled plans for a $4.2 billion Audi plant in Middle Georgia, reviving a familiar GOP election-year playbook.
The State of Politics: How The Tax Break for Data Centers Was Passed
$1.9 billion annual handout to massive tech companies quietly put into 2023-25 budget.
2.9K views · 17 reactions | Over $10 billion has been spent so far on...
Over $10 billion has been spent so far on ads for the midterm elections, according to media tracking firm AdImpact. But who is paying for those ads? We dug into the data. https://wapo.st/4zKTGk7
Data center boom brings premium growth, risks
Billions of dollars in data center construction are generating significant insurance demand, but a growing challenge for insurers is the accumulation of exposures rather than a broad shortage of…
Meta looks to raise up to $95 billion from stock sales for AI build out
Meta is seeking more cash as it spends heavily on AI infrastructure, data centers, and computing power as it develops consumer AI products.
The Daily Mauling: 10/26/26
Kansas Jayhawks News The LJW talks about KU’s exhibition loss to Duke, with a focus on Bill Self’s small ball lineups UNLV coach Josh Pastner is whining about having to play Trey Kaufman-Renn when the Rebels visit Lawrence. Interesting complaints for a guy who went out and got AJ Storr this offseason SI also brings […]
The Political Calculus Behind Newsom’s Opposition to California’s Billionaire Tax
Proposition 40 proponents say the tax would help backfill federal Medical cuts. But as Newsom weighs a presidential run, is he also looking ahead to how it might play to donors and voters?
Schools Wrestle With Exploding Health Costs: 'Medical Inflation Is Crushing Us'
School districts face a dilemma as healthcare costs surge, but they're getting creative.
Exclusive: Health tech PE megadeals surge as deal volume drops
The average health care buyout size jumped to $3.4 billion in the first half of 2026.
Did Elizabeth Holmes and Billy Evans get paid for their documentary?
Nathan Fielder’s documentary turns a dispute over paying its subjects into a central source of tension. Here’s what we know about the proposed deal.
Student-loan borrowers' key midterms issue: affording higher bills
Over 10 million student-loan borrowers are behind on payments. Some are hoping the midterms will prompt policy change to protect those in default.
Micro1 invests $1B to license data for AI model development
Micro1 is pledging $1 billion to gobble up more companies' internal data for licensing to AI model developers, part of a new wave for the tech.
Smithsonian scientists launch "Lumina" simulation to model early universe
Researchers introduce "Lumina," a massive cosmological radiation-hydrodynamics simulation designed to model the universe's first two billion years
Bipartisan bankruptcy bill will help struggling small businesses
It’s good for for creditors and landlords, too.
Hollywood's uncanny evolution of evil billionaire tech bros
If you really want to understand the extent to which everyone thinks Silicon Valley is so uncanny these days, watch "Cupertino."
Raye's three songs enter Spotify's Billions Club
Raye's songs 'Where Is My Husband!,' 'Prada,' and 'Escapism' reached one billion streams on Spotify.
Goldwind Science & Technology: 9M26 profit reached RMB2.9 billion as WTG sales rose and backlog hit 57.0 GW
9M26 revenue was RMB52.0 billion and attributable net profit RMB2.9 billion. WTG sales rose 3.02% YoY, while total backlog reached 57.0 GW; operating cash flow was negative RMB30 million.Original document: Goldwind Science & Technology Co. Ltd. Class A [002202] Slides Release — Oct. 26 2026This is…
Chargers' Dalvin Tomlinson predicted to reunite with former team
NFL insider Bill Barnwell suggested that the Chargers trade defensive tackle Dalvin Tomlinson to a team he previously played for.
SpaceX secures $40B in financing for GPUs as Elon Musk warns of AI cloud industry consolidation
SpaceX closed $40 billion in debt financing for GPU purchases as Elon Musk warns AI debt markets have shut off access for most companies.
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
Jack White Mourns Brother Eddie Gillis, Longtime Manager of Third Man Pressing
"The world lost a beautiful soul today,” White wrote of his older brother.
Trump rails against Bill Maher in his longest Truth Social post ever
President Donald Trump has just penned his longest Truth Social post ever, according to a CNN analysis and a third-party tracking firm.
Earnings to watch: Caesars Entertainment (CZR) reports Q3 results tomorrow
Hotel and casino entertainment company Caesars Entertainment NASDAQ:CZRwill be reporting earnings this Tuesday after market close. Here’s what to expect.Caesars Entertainment beat analysts’ revenue expectations last quarter, reporting revenues of $2.99 billion, up 3% year on year. It was a softer q…
Scientists Reversed 60 Years of Cellular Aging. Can It Work in Humans?
Scientists reversed 60 years of cellular aging in a lab. As billionaires pour money into longevity research, could humans be next?
Supercomputer reveals first two billion years of ‘cosmic web’
The Center for Astrophysics’s simulation offers the most detailed look yet at the infancy of the universe after the Big Bang
6 stellar images of the early universe
The most detailed simulation of our universe’s first 2 billion years to date.
Primark's Business Doesn't Make Sense
In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot
Rep. Carbajal Meets with Cottage Health’s Head Honchos in Santa Barbara as They Brace for ‘Big Beautiful Bill’ Impacts
Trump’s bill expected to leave close to 40,000 Central Coast residents without health coverage, another 37,000 with higher premiums, and a roughly $40 million initial impact on Cottage.
New heist movie starring Pete Davidson to finally hit theaters in November
Billed as ”Point Break" meets “Fast and Furious,” Davidson will share the silver screen with Nicholas Hoult and Zoë Kravitz.
Editorial: Company mergers are causing more harm to the entertainment industry than good
Two weeks ago, Paramount officially completed its $110 billion purchase of the historic Warner Bros.
NFL Week 7 Sunday afternoon open thread
Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia
MTSU named among Billboard's Top Music Business Schools for 12th year in a row
Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Trump touts U.S. oil business making ‘hundreds of billions’
President Trump tells rallygoers in Georgia that the United States’ oil and gas business is making “hundreds of billions of dollars because of what’s happened in the Middle East,” and predicts that prices at the pump will “come way down.”
Petition to "Save Mass Effect" reaches over 170k signatures as fans plan billboard outside EA HQ
The Mass Effect community is not going down without a fight
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer. Despite the single mother's positive outlook, the financial strain combined with the high cost of living is overwhelming. And it's
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
She voted for Trump every time. Then came cancer and the bills
Cindy Banda faces mounting medical bills after battling breast cancer.
Bill Belichick speaks on loss to Syracuse
What Bill Belichick said after UNC football lost to Syracuse.
Jodi's Journal: The end of an on-air era
Congratulations to a local broadcasting legend as Bill Zortman logs off the air later this week after a 60-year career.
Three giant black holes discovered in a galaxy from the dawn of time
Astronomers have discovered three actively feeding black holes inside a single galaxy more than 12.5 billion light-years away, revealing a remarkable scene from the universe’s infancy. Two of the black holes are separated by just 620 light-years and are expected to eventually merge, while a third lurks farther away. One weighs an astonishing 80 million suns, and another is growing faster than conventional theories predict.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
What Californians should know about Prop. 42
The measure could block the billionaire tax — and more.
AP Exclusive: Trump’s border chief defends wall plans in Texas’ Big Bend despite a court setback
The Trump administration's top border official is defending plans to build a wall in Texas' Big Bend region. Customs and Border Protection Commissioner Rodney Scott argues the entire $46 billion
Are the Bills playing today? NFL Week 7 schedule, next game, AFC East standings
The Buffalo Bills and star QB Josh Allen are off to a terrific start to the 2026 NFL season. Here's what's on deck for the team in Week 7.
Student-loan borrowers facing higher bills are slashing their budgets
From cutting back on groceries to delaying starting a family, student-loan borrowers describe the changes they're making to afford higher payments.