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'Iran War Participation Trophy' for Trump is on tour, joins Instagram
A 10-foot sculpture of a golden trophy made for President Trump by the anonymous arts activist group Secret Handshake is officially on tour, with an Instagram page and appearances in D.C., New York and Minneapolis.
A democratic socialist in the White House? Activists are thinking big.
The Democratic Socialists of America summit was abuzz about whether to endorse a presidential candidate, potentially Alexandria Ocasio-Cortez.
Democrats’ ‘climate hushing’ prompts activists to turn up the volume
Nationwide actions seek to counter view that talking about climate crisis distracts from affordability messaging
The Thorny Politics of Protest Photography
A new documentary follows the work of activist and photographer Misan Harriman, but risks aestheticizing the movements he captures.
Charlie Kirk attacked for his politics: Prosecutors
Tyler Robinson, the man accused of killing conservative activist Charlie Kirk, targeted Kirk for his political beliefs on LGBTQ issues, prosecutors alleged Tuesday. Kirk was outspoken about his opp…
Prosecutors say Charlie Kirk was attacked for his politics, cite anti-LGBT views
Tyler Robinson, the man accused of killing Charlie Kirk, targeted the right-wing activist for his political views, prosecutors said on Tuesday, citing Kirk's opposition to gay marriage and transgender rights.
Sophie Cunningham rally rocks WNBA game as 'save women's sports' activists face counterprotest
Footage shows crowds holding signs outside the Seattle Storm game as Sophie Cunningham fans rallied in support of her women's sports stance.
Vietnam Should Release Ailing Political Prisoners
Can Thi Theu, 64, is serving an eight-year prison sentence at Prison No. 5 in Vietnam’s Thanh Hoa province because she joined protests against land confiscation and environmental degradation in 2016 and publicly supported other human rights activists and political prisoners languishing behind bars.
Revealed: history of Spain’s fearless 1970s trans-rights political collective
Pioneering activists risked arrest and imprisonment amid lingering persecution after Franco dictatorship
The White House’s MAHA Gatekeeper
A policy wonk who could lead the FDA has angered “Make America Healthy Again” activists.
Erin Brockovich's crusade against data centers is going crowd-sourced
The environmental activist said there is a lack of transparency in the country's data center construction.
India’s cockroach politics is no joke
The Cockroach Janta Party has crept onto the political scene at a time when Indian democracy is struggling.
Without Platner, Maine Democrats Scramble to Keep Grassroots Energy Alive
Graham Platner’s campaign for Senate imploded last week. The activists who backed him are seeking a candidate to carry his populist message in the race against Republican Susan Collins.
‘Where does that leave our local business?’
Edgartown’s Winter Street was divided into two sides Friday morning. On one side, a long line of mostly visitors awaited their chance to peek inside the pop-up store of the Amazon-affiliated business Shopbop. Right across the road, a group of local business owners and eager activists stood holding signs in protest against the event. The […]
Appeals for prominent Indian activist to end hunger strike as he risks health to demand education reforms
Well-known activist Sonam Wangchuk hasn't eaten in nearly 3 weeks, endangering his health as he demands changes to India's exam system.
Sonam Wangchuk: Indian activist urged to end hunger strike as he loses 9.1kg in 19 days
The environmental activist has been on a hunger strike for 19 days and has visibly weakened.
Indian Activist’s Health Worsens in Hunger Strike for Students
The health of a well-known Indian activist is deteriorating more than two weeks into his hunger strike over exam paper leaks, putting pressure on the government to respond to one of the country’s most prominent youth-driven protests in years.
Activist, 84, is still in SF's political mix
Hene Kelly has been a crusader for more than 50 years.
Tommy Robinson’s Musk-funded Russia trip spurs call to defend UK democracy
Ed Davey voices concern about the Musk family foundation taking the far-right activist on a visit to Moscow
They're Building Half A Bridge to Save Science...
Today’s post is about science: what you can do now to protect it from unprecedented threats, and how your action is the first half of a long-term program that Congress must take up next. Let me start with describing the embryonic state of science advocacy. There are many well-meaning organizations: the American Association for the Advancement of Science, Research!America, and subject-specific organizations such as the Society for Neuroscience and the American Physical Society. Their general approach is to emphasize the common good: the remarkable value that science and innovation have provided to all Americans. However, these organizations are offering an incomplete solution. Before I start, a preliminary: If you already know about the threat, go ahead and weigh in with OMB at this link. Ideas about what to say come from Research!America and the American Physical Society. You have until Monday, July 13 at 11:59pm Eastern. Then come back here and read the rest of this post. Finally, get in touch with whoever is likely to be your next member of Congress in 2027. The threat: An end to merit-based science… The onslaught of attacks on science is accelerating. It’s not just cuts to grants, which was the last battle. That battle is not done yet, but there is a new and worse threat. Now comes a proposed public rule from the Office of Management and Budget. The rule would take decision-making power over grants away from experts and put it into the hands of political appointees. Former NIH official Elizabeth Ginexi wrote an excellent summary of what OMB is trying to do, which is codify the executive branch’s ability to award or terminate grants, for arbitrary cause or no stated cause. Since World War II, a necessary step in scientific grant-making has been consideration of scientific merit. This approach has made America into a dominant scientific superpower, the envy of the world. Of course, political considerations do come into the mix. The proposed rule tilts the balance dramatically away from merit. …but why? Many people have difficulty comprehending why Russell Vought and OMB would want to damage science in this way. If you’re a working scientist, you are likely to be particularly uncomprehending. Who would hurt an activity so self-evidently good? The answer is: this is part of the program to replace the rule of law with a personalist regime. OMB Director Russell Vought, a Christian nationalist, would like to implement what legal scholars call a “unitary executive,” and what I would call a dictatorship. Or if you like, a personalist authoritarian regime. I am a working scientist. This rule will debilitate my research. It may chill the speech of scientists for speaking freely in the public sphere. It is a form of personalizing power and decision-making within the executive branch. In short, it sacrifices science in the service of tyranny. To Russell Vought, a decrease in the quality of science might be an acceptable cost. He might even consider it an added benefit to weaken a pillar of soft U.S. power based on knowledge and skepticism. The professional societies are building half a bridge The nonprofits are asking you to make public comment. Public comment is like building the first half of a bridge. Before implementation, OMB is compelled by law to have a period of public comment. Rules have to be consistent with the law and the Constitution. They express the federal government’s stance toward how those laws will be implemented. When a presidential administration works in good faith, these public comments are used to inform their eventual action, and sometimes mitigate it. The comment period reflects our First Amendment right to petition our government. The executive branch is then supposed to take those comments into account - completing the bridge between us, the people, and our government. Project 2025 seeks to take away the second half of the bridge. We have to replace it. The first half of the bridge Organizations like AAAS, Research!America, and SfN are partly right. You should certainly comment. Their core model is earnest: if enough of us make noise, then we will achieve change. This idealistic point of view is offered in good faith. That point of view is also currently bullshit. The fundamental reason is that the federal rulemaking process has two parts: There has to be a period of public comment. OMB makes the final rule…but is free to disregard public comment. Oops. That’s a loophole. However, not all is lost. Congress can complete the bridge Congress has enormous power. That power suggests a roadmap for how to proceed. This lawless administration is still going to issue that rule. Nonetheless, your comments still play an essential role. Here are two steps you can take. Step 1: Send your comment to your Representative and Senator. Whether they are Democrats or Republicans, many of them support science. Whatever you wrote as public comment in the Federal Register, also send it to your member of Congress. You can include information about jobs in your district or state by looking at Joshua Weitz’s ScienceMatters interactive map. Call the U.S. Capitol switchboard at (202) 224-3121 and give your town, zip code, or state, then deliver your message. Step 2: Politicize the hell out of science. You heard me, politicize it as an issue. We hear a lot from the old scientific establishment about science being nonpartisan. This is obsolete, sentimental thinking. Under normal conditions, it was true. But we can no longer make that assumption. We can keep on pretending, but we’re putting science at risk. There is a way forward. Rules are subordinate to the law…and Congress makes laws. Therefore Congress can step in. In this fall’s election, it is likely that Democrats will retake the House of Representatives. That puts at least one chamber of Congress in the hands of Democrats. They are far more inclined than the current Congress to investigate and legislate. This opens a path to undoing the damage. It also creates a permission structure for pro-science Republicans to find a way back from the brink. We have to encourage them. In the House, every district is up every two years. In your district, contact both of the major party candidates. If your state has a Senate race, contact those candidates too. Specifically mention the proposed OMB rule. Ask for two things: For this year’s appropriations process in August and September, ask that amendments be added to stop the implementation of the new rule. Those amendments should support peer-reviewed science and stop political interference. Looking ahead to next year, ask the Congressman/Congresswoman/Senator to work to hold hearings in 2027 on the importance and benefits of peer-reviewed science for health and prosperity. What hearings and amendments will accomplish Congress can use its investigatory power to summon heads of agencies and the director of the OMB. That will allow fact-finding regarding the consequences of this rule. Congress can override the rule through the appropriations process. They can write into statute a requirement to follow peer review and best scientific practices. In this way, Congress can stop the attacks on science. Postscript: Moving forward Now I have a request for you, to help me. As many of you know, I ran for Congress in order to save democracy and science. Although I did not win, that battle continues by other means. I met and heard from thousands of supporters both here in New Jersey and nationally. I learned that pro-science, pro-democracy activists have the potential to become a much greater force. In the weeks and months ahead, I will be building ways to harness that energy. I will be announcing those plans soon. In the meantime, an important step is to wind down the Congressional campaign, which has a few remaining bills to pay. Please help me retire that last debt.
What's next in the battle to 'save women's sports' after SCOTUS ruling — and the hidden damage driving it
Women's sports activists warn of sexual abuse risks in the states that let males compete in girls' sports after SCOTUS ruling.
The EPA promised a MAHA agenda. It has yet to materialize, frustrating activists
After Make America Healthy Again activists drew up a petition to get him fired, EPA administrator Lee Zeldin pledged to release a formal agenda of MAHA priorities his agency would pursue. But eight months after its first mention, the so-called MAHA agenda is nowhere to be found.
Joe Klein: At 80, Here’s What I’ve Learned About Politics—and Life
I am 80 years old, this year of our 250th anniversary, and I find myself a cliché. My life has been a common political journey, from left to center. I recently took the Pew Research Center’s “political typology” test and found that I was a “pragmatic and polite conservative,” which seemed a rather abstruse basket: A politically mixed (though Republican-tilting) group, they lean conservative on economics and the role of government, while tilting more liberal on issues related to race and foreign policy. They prize civility and cooperation in politics. Well, that sounds pretty mushy—and I find it hard to square with the strong opinions I have on many issues. I’ve voted for Democrats in federal elections, but I grow more Republican the closer I get to local politics. Democrats, I’ve found, simply aren’t very good at running things, especially school systems, where they are in the thrall of the teachers unions. My friends joke about my obsession with the unions. They know all my lines. If industrial unions are organized against the power of capital, who are the public employees organized against? But enough of that. I’ve ranted that rant too often, and my political journey has been more complicated than that one issue. It has been empirical, based on actual experience—on a lifetime of reporting and a lot of reading. An early example: I was a journalist with the underground press in Boston at the turn of the 1970s and considered myself a member of the antiwar and civil rights movements. The first big issue I covered was busing to achieve school integration. Yes, the white bigots were disgusting. But I couldn’t find any black parents who favored the plan to bus their children to schools outside their neighborhoods either. Black activists and politicians—and white liberals—were gung ho, but not actual parents of black kids in school. Busing was a form of social engineering imposed from on high, by a judge—W. Arthur Garrity—who lived in a wealthy liberal suburb. Wealthy liberal suburbs were not affected by his plan, of course. I began to see that there were limits to what government could do, especially when it came to changing a society’s culture.
EPA promised a Make America Healthy Again agenda. It has yet to materialize, frustrating activists
Trump’s second-term EPA has vigorously pursued a deregulatory agenda.
EPA promised a Make America Healthy Again agenda. It has yet to materialize, frustrating activists
After Make America Healthy Again activists drew up a petition to get him fired, Environmental Protection Agency administrator Lee Zeldin pledged to release a formal agenda of MAHA priorities his agency would pursue.
Wisconsin Supreme Court refuses to release voter records sought by conservative activist
The case has been wending its way through the courts for years and stems from attempts by conservatives to overturn President Joe Biden’s victory in Wisconsin over President Donald Trump in 2020.
The Politics of Provocation: The ECtHR’s Ruling in Miladze v Georgia
A recent judgment of the European Court of Human Rights concerning a TikTok video published by a Georgian self-defined civil activist adds another layer to the Court’s increasingly messy Article 10 case law. The applicant repeatedly insulted public officials in crude and sexually explicit terms while broadcasting to a large online audience. Domestic courts imposed only a modest administrative fine, later reduced on appeal. The ECtHR did not find a violation of the applicant’s right to freedom of expression – raising several questions about the limits of legitimate political speech online.
Meet the MAGA darling mobilizing Americans against Big AI
Amy Kremer was a "Stop the Steal" activist who helped organize the January 6 rally in 2021. She's now mobilizing against AI data centers.
White House report brands Smithsonian leadership as radical activists who can't be trusted
The report released late on Independence Day by the White House Domestic Policy Council comes in the midst of Trump’s aggressive campaign to overhaul some of Washington's most sacred cultural and historic institutions.
White House report brands Smithsonian leadership as radical activists who can’t be trusted
A White House report brands the leadership of the Smithsonian Institution, especially at the National Museum of American History, as radical activists who cannot be trusted.
Pols & Politics: Aging Ed Markey highlights endorsement from aging Jane Fonda
An aging Sen. Ed Markey is showing off a new endorsement of his reelection campaign by 88-year old celebrity and longtime political activist Jane Fonda.
Riley Gaines and women's sports activists share honest reactions, emotions to SCOTUS Title IX ruling
Riley Gaines says the Supreme Court women's sports ruling is worth celebrating but admits the years-long fight has left her deeply exhausted.
Immigration activists react to Supreme Court decisions
The court upheld the principle of birthright citizenship for all, but enabled restricting asylum seeking and revoking temporary protected status.
Inside the Supreme Court battle to 'Save Women's Sports'
Riley Gaines and Save Women's Sports activists celebrate after the Supreme Court upheld state laws banning trans athletes from girls' sports.
First Amendment's freedom of assembly becomes 'corporeal politics,' activist says
Where and how you assemble is 'ever more important' in today's political climate, Indivisible Bellingham's Robin Thomas says
In St. Pete, activists speak out for science
In a small St. Petersburg demonstration, scientists and their supporters fight back against government cuts to research.
Dem running for Pelosi’s seat mocked after anti-Israel hecklers chase him from SF Trans March
Videos show state Sen. Scott Wiener being shouted down by anti-Israel activists in San Francisco, sparking widespread mockery from conservatives.
Texas Democrats leave convention united in effort to end GOP’s 30-year hold on state politics
Texas Democrats spent their 3-day convention in Corpus Christi rallying party activists, training volunteers and making the case for Democratic policies and candidates across the state ahead of the 2026 midterm elections.
The Anti-Data-Center Movement Is Reshaping Michigan Politics
Climate activist Will Lawrence cofounded the Sunrise Movement. Now, he has shifted his focus in his attempt to compete for a swing-district seat by calling for a data center moratorium.
How an under-the-radar GOP official is shaping local voting plans in North Carolina
After Republicans shifted key election authorities to State Auditor Dave Boliek, Democrats and voting rights activists have criticized his involvement in early voting site discussions.
Texas Democrats leave convention united in effort to end GOP's 30-year hold on Texas
Texas Democrats spent their 3-day convention in Corpus Christi rallying party activists, training volunteers and making the case for Democratic policies and candidates across the state ahead of the 2026 midterm elections.
Greens examining how party decides policy as membership triples under Zack Polanski
Exclusive: Concerns in-person vote system is giving bigger say to organised fringe activists who can attend conference
Trump tamped down fights over abortion and marriage. Conservative activists want to bring them back in 2028
Since returning to the White House, Trump has largely sidestepped causes long championed by the conservative faith movement
Paxton’s support for IVF highlights broader divide among GOP
Anti-abortion activists believe life begins at conception, so many oppose IVF because it often destroys some embryos.
Louisville coaches can't afford to stay sidelined amid NCAA changes
The NCAA has brought college sports into instability, which is why coaches like Louisville's Jeff Brohm and Pat Kelsey have to be activists.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Supreme Court sides with weedkiller Roundup, making some MAHA activists angry
Here's what to know about health concerns surrounding glyphosate and the weedkiller Roundup following a major Supreme Court ruling.
MAHA is breaking up with Trump. Now what?
A coalition of wellness-conscious activists is changing course, with big implications for 2028.
Susan Collins is testing whether old school politics still work
In the modern era, political activists want their representatives to fall strictly in line. To the base, the independent centrist is no longer a hero; they are a villain to be purged. But Susan Collins has a pitch that she is an independent voice.
Bill Ferguson wins Maryland state Senate primary after opposing Democratic redistricting plan
Incumbent Bill Ferguson defeated activist Bobby LaPin in the state legislative race in Baltimore, The Associated Press projected.
Whistleblower investigating Ecuadorian president’s family business was murdered, activists say
Monika Silva Koniuszek died from a blow to the head and strangulation, postmortem found, despite government claim of suicide
Longtime Georgia radio host, political commentator Martha Zoller has died
Martha Zoller, a longtime Georgia radio host, political commentator, and conservative activist whose voice became a fixture in state politics for more than three decades, has died.
Jewish voters express growing isolation amid rising antisemitism in both major political parties
Faced with anti-Israel and even anti-Jewish sentiment by party activists, and by an increasing number of political candidates, many Jewish voters are facing uncomfortable choices as they cast their ballots this year.
“Criminal Approach to Politics”: Trump Ally Abelardo de la Espriella Wins Colombian Presidency
Right-wing Trump ally Abelardo de la Espriella has clinched a narrow victory in Sunday’s runoff presidential election in Colombia, defeating leftist Senator Iván Cepeda, an ally of current President Gustavo Petro. De la Espriella ran a fearmongering, “tough-on-crime” campaign, promising to build mega-prisons inspired by El Salvador’s authoritarian President Nayib Bukele, to bomb “narcoterrorist camps” and to abandon Petro’s peace efforts. His reported victory is also a win for U.S. President Donald Trump, whose administration is waging an intensifying “war on drugs” across Latin America, targeting left-wing leaders like Petro with false allegations and threats of military intervention. “De la Espriella clearly represents a criminal approach to politics: lying, propaganda, coordination and collusion with criminal narcotrafficking, restriction of rights, and money laundering,” says longtime Colombian activist Manuel Rozental. With his victory, says Rozental, “We expect to have military operations and a U.S. intervention within the country. We expect to have human rights abuses. We expect to have militarization. And it’s all for the extraction of resources and the link of drug trafficking to the U.S. government, U.S. interests and global mafia.”
Jewish voters express growing isolation amid rising antisemitism in both major political parties
Faced with anti-Israel and even anti-Jewish sentiment by party activists, and by an increasing number of political candidates, many Jewish voters are facing uncomfortable choices as they cast their ballots this year.
The Growing Political Power of Anti-Data Center Activists
From Arizona to Seattle, anti-data center activists are on a roll—and increasingly using elections to pressure politicians.
Türkiye’s Democratic Breakdown: Authoritarian Consolidation and the Sources of Resilience
Lessons from Global Democratic Resistance is a public panel series that brings together frontline activists, civic leaders, institutional actors, and field‑informed scholars to examine how democratic actors have resisted, responded to, and learned from democratic backsliding across countries. The series aims to identify practical lessons and comparative insights for those defending democracy today and is organized by the Carnegie Endowment for International Peace in collaboration with the Ash Center for Democratic Governance at the Harvard Kennedy School; the Cornell Center on Global Democracy; Perry World House at the University of Pennsylvania; the Kellogg Institute for International Studies at the University of Notre Dame; the Democratic Futures Project at the University of Virginia; Stanford’s Center on Democracy, Development and the Rule of Law.
Charlotte mayor finalists on who holds power in city hall: activists or business?
The City Council will select Charlotte’s next mayor from a pool of five finalists amid a changing political landscape.
In private speech, Blanche tried to mend fences with critical conservative activist
At President Donald Trump’s Miami hotel, acting Attorney General Todd Blanche recently tried to smooth things over with a conservative watchdog group whose anger at the Trump administration was building on multiple fronts.
Trump mulls co-endorsement in South Carolina as governor’s race proves tight
An endorsement of both candidates would be the latest example of the president hedging his bets to avoid a fight with conservative activists.
This Teen Activist Wants to Make Sure No Girl Is Denied the Right to Play Sports
With Girls4Sports, Maegha Ramanathan has built a global youth-led movement to expand access to athletics and empower the next generation of female leaders
Why is Tupac headlining an upcoming video game?
Gamers and influencers watching Summer Game Fest mostly expressed shock and confusion at the inclusion of the influential American rapper and political activist who died in 1996.
Activists want vote to lock taxes for housing
Ballot measure would counter mayor, supervisor's plan.
Hochul defends fracking ban as Blakeman presses for it to be overturned
The process has long been criticized by environmental activists who argue it poses risks to public health.
Activist Investors Really Want Elden Ring Developer To Self-Publish
'We think the current arrangements with the game publishers like Bandai Namco and Activision are no longer good deals for the Company'
How an activist network built pressure without political power
When Rainforest Action Network began in 1985, it had little of what usually makes an organization powerful. It had no large budget, no legal department, no reliable access to politicians, and no formal way to force global corporations or development banks to change. It had Randy Hayes, a wide activist network, a way to connect […]
'I can't stand by': Martin Hyde jumps into open SD 22 race
After a controversial run for Congress, the Sarasota activist is back on the ballot. Do you know who he is?
Months after the Minnesota ICE surge, the backlash is driving a Senate primary
Progressive activists have rallied behind Lt. Gov. Peggy Flanagan, while Rep. Angie Craig has warned that Democrats could lose the seat if they nominate a candidate too far left.
Lawmaker blacklisted by Beijing makes long-shot bid to become Taipei mayor
Ruling DPP’s Puma Shen made his name as an outspoken civil defence activist, but faces an uphill battle to unseat the KMT’s Wayne Chiang.
Democratic activist withdraws Platner endorsement amid latest revelations
Graham Platner to hold rally as scandals shake up campaign
Platner, an oyster farmer and progressive activist, is key to the Democrats' hopes to take back the U.S. Senate this year as the party needs him to defeat longtime Republican Sen. Susan Collins.
MAHA moms test their influence in US glyphosate fight
'Make America Healthy Again' activists see legislative wins, White House disappointments and questions for the midterms.
Steve Hilton and Xavier Becerra lead California governor primary vote count
Another Democrat, billionaire climate activist Tom Steyer, is in third place as the tally continues.
District Lines Are Shifting Fast in the South. Voters Are Rattled.
Republican officials are jubilant, some voters are confused and concerned, and civil rights activists are gearing up for the fight of a generation.
Hasan Piker defends pro-communist, anti-ICE Singham network activists as 'wonderful people'
Marxist influencer Hasan Piker defended the Singham-funded activist network at a New Jersey ICE protest and dismissed federal scrutiny of his Cuba travel.
Delaney Hall protests intensify as far-left activists, ICE supporters converge in New Jersey
Communist activists, far-right group clash outside Delaney Hall in Newark, transforming the protest into a broader political spectacle.
Live: Minnesota Republicans kick off convention weekend with governor debate
Party activists hoping to break a statewide losing streak are gathering in Duluth this weekend to debate and endorse candidates for governor, U.S. Senate and other statewide offices.
IAM Activists Build Political Power at Weeklong Training Seminar
IAM Union political activists from across North America gathered this week at the William W. Winpisinger Education and Technology Center for the IAM Political Education Seminar, a weeklong training focused on strengthening political action, legislative advocacy, member mobilization and worker power. Throughout the week, participants received hands-on training on lobbying elected officials, organizing political campaigns,
Ball State Settles With Ex-Employee for $225,000 Over Charlie Kirk Posts
Ball State University is the latest institution to agree to pay workers who lost their jobs over their posts about the conservative activist.
Moderate Muslim activist warns Mamdani promoting extremist politics
Anila Ali says New York City Mayor Zohran Mamdani represents an extreme form of Islamism and is damaging both moderate Muslims and Jewish communities in New York ahead of a planned protest outside Gracie Mansion.
Rafe Pomerance, the Paul Revere of Climate Change, Dies at 79
An environmental lobbyist and activist, he was a pivotal figure in drawing public attention and political support to the existential issue.
Agitators united by Chinese money, hate for America target data centers, experts warn
Experts warn climate activists, anti-Israel protesters and other movements have formed an anti-American alliance now targeting U.S. AI infrastructure.
Feds subpoena Hasan Piker, Medea Benjamin over Cuba trips
Hasan Piker and CodePink cofounder Medea Benjamin face Treasury subpoenas in a federal probe into whether activists violated U.S. Cuba sanctions.
Oakland: Health Workers, Activists Protest H.R. 1 Funding Cuts, Call For Billionaire Tax
Around 80 people participated in a symbolic "die-in" in East Oakland on Thursday to protest federal funding cuts to healthcare.
Jack Davis, the most feared and loathed man in San Francisco politics, dies at 79
How a kid who grew up in a Pennsylvania funeral parlor went from gay rights activist to S.F. political kingmaker
Elliott builds big stake in life-science tools supplier Bio-Rad Labs, WSJ reports
Activist investor Elliott Investment Management has built a sizeable stake in U.S. diagnostics supplier Bio-Rad Laboratories NYSE:BIO, and plans to push the company to boost its underperforming stock price, the Wall Street Journal reported on Sunday.Bio-Rad's shares have fallen more than 18% so fa…
Elliott Builds Stake in Life-Science Firm Bio-Rad, WSJ Says
Activist investor Elliott Investment Management has built a sizable stake in Bio-Rad Laboratories to boost the firm’s underperfoming stock price, the Wall Street Journal reported, citing people familiar with the matter.
Exclusive | Activist Elliott Builds Big Stake in Life-Science Tools Supplier Bio-Rad
Elliott also has a stake in German lab-equipment supplier Sartorius, where Bio-Rad is also an investor.
What GOP officials are hopeful — and worried — about six months from the midterms
NBC News spoke to roughly 30 Republican National Committee members and GOP activists around the country about how the party can keep control of Congress in November.
Groups rally to defend Black political representation in civil rights birthplace
The rally will begin in Selma, where a violent clash between law enforcement and voting rights activists in 1965 galvanized support for passage of the Voting Rights Act.
Boston-black-politics-opposition-Wu
I’m skeptical, but that’s certainly the impression being given by a group of longtime community activists waging a high-profile battle against City Hall.
Netanyahu testifies his health is 'top decile' in libel suit over cancer reports
The Prime Minister Testified in Court After He Sued an Anti-government Activist and Two Journalists Over Reports on His Health. In April, a Medical Report Revealed Netanyahu Had Been Diagnosed With Prostate Cancer and Underwent Radiation Therapy Without Informing the Public in Real Time
Google launches new Android security feature to help uncover spyware attacks
Intrusion Logging is a new part of Android’s Advanced Protection Mode, which aims to help protect human rights activists, journalists, and dissidents from government spyware attack and law enforcement forensic devices.
Panicked California Democrats are pushing a risky strategy: Wait 'til the last minute to vote
Liberal California activists are urging Democrats to wait until the last minute to vote in the race for governor, then support the frontrunner in the polls.
Pete Davidson Jabs Charlie Kirk, Kanye West In Back-To-Back Punchlines
The "Saturday Night Live" alum took on the rapper and the far-right activist, all in the name of knocking a Trump-adjacent comic.
Music festival to benefit community action groups
The Bad Beaver Music Festival will take place at Bad Beaver Farm in Ellsworth on Saturday, May 23, from 4-8 p.m. The festival benefits Acadia Action and Hancock County Activists.
Alarm grows over health of Iran’s female political prisoners
Rights activists have raised renewed concerns over the health of prominent female political prisoners after Nobel Prize laureate Narges Mohammadi was transferred to a hospital in Tehran and reports emerged of worsening conditions for jailed activist Fatemeh Sepehri.
Iran releases Nobel laureate Narges Mohammadi on bail amid health fears
Iranian Nobel Peace Prize winner Narges Mohammadi has been released on bail and transferred to Tehran for urgent medical treatment after supporters warned she was at risk of dying in prison. The activist,…
GUEST ROOM | Unfinished Campus Business: Memorializing Three Young People Who Gave Their Lives for the Right to Vote
Bill Schechter ’68 argues that three civil rights activists, including a Cornell alum, whose murders spurred the passage of the Voting Rights Act of 1965 deserve to finally have a memorial erected at Cornell as a daily expression of the University's unwavering values.
White House hosting anti-abortion activists amid Trump backlash
Senior Trump aides will host anti-abortion activists for a meeting at the White House on Friday, in an effort to temper growing criticism over the administration’s priorities, a person familiar with the matter told CNN.