SCROLL NEWS / DISCOVERY

Search headlines

Find the stories shaping the conversation.

Search mode
Refine results
Active filters Keyword All time

Results for " Time " 24,394 found 🔀 AI-powered Shuffle

MacBook Neo Silences Critics Over 8GB RAM Being Inadequate; Can Open 60 Apps In Unison While Windows Laptop Powers Off Performing The Same Task

A YouTube channel decided to take the MacBook Neo for an apps stress test and opened up 60 apps at the same time to see if that 8GB RAM will be sufficient

wccftech.com logo
Mar 23 • 5:31 PM EDT • Technology • wccftech.com
Scientists Connect “Time Crystals” to the Outside World in Groundbreaking Experiment

A newly demonstrated link between a time crystal and a mechanical system opens a door scientists once thought closed.

scitechdaily.com logo
Mar 23 • 4:46 PM EDT • Science • scitechdaily.com
'Sled head': Lawsuits against USA Bobsled/Skeleton allege brain injury

Three personal injury lawsuits have been filed on behalf of elite bobsledders who claim officials intentionally concealed evidence that the sport causes brain injuries.

latimes.com logo
Mar 23 • 4:31 PM EDT • Sports • latimes.com
Science Through Shadows: How Astronomical Alignments Reveal the Universe

When one celestial object passes in front of another, it can cast a shadow that travels across space – and sometimes across Earth. These moments of alignment, known as eclipses, occultations, and transits, allow scientists to study distant objects in remarkable ways. By observing how light changes when an object briefly blocks another, astronomers can measure sizes and shapes, detect atmospheres, and refine the orbits of asteroids and planets.

science.nasa.gov logo
Mar 23 • 3:47 PM EDT • Science • science.nasa.gov
Deep dive
😐 Neutral (17%)
ahah
73%
wow
27%
Opinion | We Can’t Let Crypto and A.I. Buy the Policies They Want

We can’t let crypto and A.I. buy the policies they want.

nytimes.com logo
Mar 23 • 3:45 PM EDT • Politics • nytimes.com
UCI Health says it will lay off 150 in 'strategic restructuring'

About 1% of the system's workforce is expected to be laid off as the county's only academic health system restructures, citing cuts at the federal level.

latimes.com logo
Mar 23 • 3:45 PM EDT • Health • latimes.com
Review: Inside the night Jo Koy and Fluffy made comedy history at SoFi Stadium

The veteran comedians created an intimate experience despite the enormous venue, drawing the crowd together through storytelling and humor from start to finish.

latimes.com logo
Mar 23 • 3:06 PM EDT • Entertainment • latimes.com
Scientists Say Surprising Smells Are Unlocking the Secrets of Ancient Mummies

Analyzing samples of mummies from different dynastic periods showed how the mixtures of substances used in mummification became more complex with time.

popularmechanics.com logo
Mar 23 • 3:00 PM EDT • Science • popularmechanics.com
2026 NCAA Tournament second round schedule: March Madness bracket, game dates, tip times, TV channels

Check out the master schedule for the first and second rounds of the 2026 NCAA Tournament so you can watch all the March Madness

cbssports.com logo
Mar 23 • 2:50 PM EDT • Sports • cbssports.com
Airport chaos is adding urgency to the DHS shutdown debate. But who has the leverage?

DHS has been shut down for more than a month. But extremely long and growing TSA wait times have created newfound political urgency to reach a deal.

cnn.com logo
Mar 23 • 2:40 PM EDT • Politics • cnn.com
Deep dive
😐 Neutral (10%)
wow
62%
ahah
38%
Uncommon Ground seeks new operator as longtime Wrigleyville restaurateurs plan to retire

The longtime restaurateurs behind Uncommon Ground at 3800 N. Clark St. in Wrigleyville are seeking a new operator for the restaurant, brewery and music venue.

chicagobusiness.com logo
Mar 23 • 1:45 PM EDT • Business • chicagobusiness.com
Brian Doherty, 57, Dies; Chronicled Libertarians and Other Outsiders

Fascinated by the fringes, he wrote a definitive history of libertarianism and books about underground comics and the Burning Man festival.

nytimes.com logo
Mar 23 • 1:35 PM EDT • Politics • nytimes.com
Californians may need to mail ballots early as Supreme Court signals support for new election day deadline

California counts mail-in ballots that arrive up to seven days after election day, but that option may be deemed illegal

latimes.com logo
Mar 23 • 12:26 PM EDT • Politics • latimes.com
Voice of America Journalists Sue, Saying Trump Officials Interfered in Coverage

The journalists said in the complaint that the administration was trying to force them to be a “mouthpiece” and that one official demanded “loyalty” if reporters wanted to “keep their jobs.”

nytimes.com logo
Mar 23 • 12:15 PM EDT • Politics • nytimes.com
Antarctica could warm 1.4 times faster than the rest of the Southern Hemisphere in the coming decades, study finds

Antarctica could warm much faster than its surroundings over the next few decades due to a phenomenon known as polar amplification that is well established in the Arctic.

livescience.com logo
Mar 23 • 12:13 PM EDT • Science • livescience.com
Trump Poised to Skip CPAC For First Time in a Decade

President Donald Trump is poised to skip the Conservative Political Action Conference this week, breaking with an annual tradition that has helped define his political rise and shaped the conservative movement.

time.com logo
Mar 23 • 11:52 AM EDT • Politics • time.com
How Health Care Workers Use Medical Manikins

Medical manikns help health care workers learn how to handle fast-changing and complex scenarios.

nytimes.com logo
Mar 23 • 11:01 AM EDT • Health • nytimes.com
2026 Fantasy Baseball Rankings: Sleepers, busts, breakouts from model that nailed Cal Raleigh's epic season

SportsLine simulated the entire MLB season 10,000 times and identified 2026 Fantasy baseball sleepers, breakout and busts

cbssports.com logo
Mar 23 • 9:37 AM EDT • Sports • cbssports.com
Trump attacking Newsom's dyslexia proves president's incompetence

President Trump claims Gov.

latimes.com logo
Mar 23 • 9:00 AM EDT • Politics • latimes.com
Inaugural Health Care by Food research award honors excellence in food is medicine science

DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...

newsroom.heart.org logo
Mar 23 • 8:00 AM EDT • Science • newsroom.heart.org
Inaugural Health Care by Food research award honors excellence in food is medicine science

DALLAS, March 23, 2026 — At a time when American dietary patterns are facing renewed attention, the American Heart Association has announced its inaugural Health Care by Food™ Most Impactful Food Is Medicine Research Award, honoring the year’s most...

newsroom.heart.org logo
Mar 23 • 8:00 AM EDT • Health • newsroom.heart.org
My husband and I were laid off at the same time. Instead of panicking, we started our own business that now has 600 employees.
yahoo.com logo
Mar 23 • 7:21 AM EDT • Business • yahoo.com
UCLA tries to enjoy rare opportunity for Lauren and Sienna Betts

UCLA works to celebrate Lauren and Sienna Betts as successful sisters and individual playmakers pushing to help the Bruins win.

latimes.com logo
Mar 23 • 6:30 AM EDT • Sports • latimes.com
Spurs vs. Heat odds, prediction, time: 2026 NBA picks for Monday, March 23 from proven model

SportsLine's proven model has revealed its San Antonio Spurs vs. Miami Heat predictions and NBA picks today

cbssports.com logo
Mar 23 • 6:01 AM EDT • Sports • cbssports.com
Data centers under scrutiny by California lawmakers as fears rise about health and energy impacts

Due to health and energy concerns, the California Legislature is considering bills to prohibit data centers from being exempted from the state's stringent environmental law and impose new tariffs on new major energy users that strain power supplies.

latimes.com logo
Mar 23 • 6:00 AM EDT • Health • latimes.com
'ET's' archive has William Shatner on a whale and a young Taylor Swift

'Entertainment Tonight' is digitizing and preserving its archive of 45 years of interview set visits and red carpet walks, which include gems like George Clooney's first interview.

latimes.com logo
Mar 23 • 6:00 AM EDT • Entertainment • latimes.com
Why the BTS Comeback Concert Was a ‘Disaster’ for Some Businesses

The turnout for the K-pop titans’ show was much lower than projected by officials, hitting the bottom line of some restaurants. Shares in the group’s management company also fell.

nytimes.com logo
Mar 23 • 5:48 AM EDT • Business • nytimes.com
Where to watch South Carolina vs. USC in March Madness Second Round: Time, TV Channel

The No. 1 South Carolina Gamecocks face the 9 USC Trojans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

usatoday.com logo
Mar 23 • 5:08 AM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (9%)
love
58%
wow
42%
In California, a Republican Sheriff Seizes Ballots, Prompting Concerns

Riverside County Sheriff Chad Bianco, a candidate for governor, recently took possession of more than 650,000 ballots as part of a fraud probe. Election officials say his investigation is baseless.

nytimes.com logo
Mar 23 • 5:03 AM EDT • Politics • nytimes.com
Energy Attacks in War on Iran Could Turn Economic Shock Into Long-Term Damage

A new phase targeting oil and gas infrastructure in the Persian Gulf threatens to hurt businesses and customers around the world for months or even years.

nytimes.com logo
Mar 23 • 5:02 AM EDT • Business • nytimes.com
When Voters Worry About ‘Affordability,’ Many Point to Health Care

Democrats have had limited political success running on the Affordable Care Act, even with its relative popularity. Now President Trump’s health care cuts may have given the issue new resonance.

nytimes.com logo
Mar 23 • 5:00 AM EDT • Health • nytimes.com
Diabetes, Overlooked and Unchecked, Poses New Risks in Africa

As deaths from diabetes start to rival those from infectious threats like malaria, a new form of the condition linked to malnutrition is surfacing in patients who can afford neither screening nor care.

nytimes.com logo
Mar 23 • 5:00 AM EDT • Health • nytimes.com
TCU completes comeback, avoids Washington's NCAA Tournament upset bid

TCU women's basketball’s 62-59 overtime win over Washington in the second round of March Madness wasn’t pretty, but it was resilient.

usatoday.com logo
Mar 23 • 2:04 AM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (10%)
love
40%
wow
32%
ahah
28%
Three Years on, What Have We Learned From the Vogue Business Size Inclusivity Report?

Vogue Business began recording size inclusivity on the runway three years ago. Today, mid and plus-size representation is at an all-time low.

vogue.com logo
Mar 23 • 1:30 AM EDT • Business • vogue.com
Deep dive
😐 Neutral (8%)
wow
46%
ahah
32%
love
22%
Today's NYT Connections: Sports Edition Hints, Answers for March 23 #546

Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.

cnet.com logo
Mar 23 • 12:39 AM EDT • Sports • cnet.com
At 85, I can still work out on the bars and do headstands with my wife

Peng Lin Hua, 85, says retirement didn't slow him down. He and his wife split their time between two countries.

businessinsider.com logo
Mar 23 • 12:03 AM EDT • Health • businessinsider.com
How Obama’s Strategist Discouraged Biden From Running in 2016

In a new set of oral histories, David Plouffe, President Barack Obama’s political adviser, described how he urged Vice President Joseph R. Biden Jr. not to challenge Hillary Clinton for the nomination.

nytimes.com logo
Mar 23 • 12:01 AM EDT • Politics • nytimes.com
Michigan State basketball time, TV channel set for Sweet 16

Michigan State basketball knows when it will be playing, even before it knows its opponent in the Sweet 16 in Washington on Friday night.

sports.yahoo.com logo
Mar 22 • 11:05 PM EDT • Sports • sports.yahoo.com
CBS Sports and TNT Sports Announce Tip Times and Commentator Teams for Regional Semifinals on Thursday, March 26, and Friday, March 27
ncaa.com logo
Mar 22 • 10:41 PM EDT • Sports • ncaa.com
Bill Self says coaching future at Kansas to be determined

Longtime Kansas coach Bill Self said after Sunday's season-ending loss to St. John's that he has not yet made a decision about his coaching future, later adding that any decision will be based solely on his health.

espn.com logo
Mar 22 • 9:40 PM EDT • Health • espn.com
Jerry Hanlon, longtime Michigan football coach, dies at 96

"Michigan Athletics has lost one of the finest ambassadors and mentors our football program has ever known," U-M AD Warde Manuel said in a statement.

sports.yahoo.com logo
Mar 22 • 8:34 PM EDT • Sports • sports.yahoo.com
Alabama vs. Texas Tech odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Texas Tech vs. Alabama picks for the NCAA Tournament 2026 second-round game on Sunday

cbssports.com logo
Mar 22 • 8:03 PM EDT • Sports • cbssports.com
A promising fatty liver treatment may raise cancer risk

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.

sciencedaily.com logo
Mar 22 • 8:00 PM EDT • Science • sciencedaily.com
How the G.O.P. and Democrats Are Talking About the Surge in Gas Prices

Republicans have largely been on defense against Democratic criticism. Here are five arguments advanced by figures in both parties.

nytimes.com logo
Mar 22 • 6:58 PM EDT • Politics • nytimes.com
Two-thirds of workers are burned out—here's what science says about how to tackle it

Burnout is at an all-time high, with some studies saying two-thirds of employees now cite job burnout as a major challenge. Overwork and chronic stress do not just drain energy, they can erode health, ...

phys.org logo
Mar 22 • 6:30 PM EDT • Science • phys.org
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.

France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.

nytimes.com logo
Mar 22 • 5:03 PM EDT • Politics • nytimes.com
Israel Thought It Could Spur Rebellion Inside Iran. That Hasn’t Happened.

President Trump’s hopes that an Israeli plan to ignite an internal uprising against Iran’s theocratic government could bring the war to a swift end have so far been dashed.

nytimes.com logo
Mar 22 • 2:45 PM EDT • Politics • nytimes.com
The Times' top 25 high school baseball rankings

St. John Bosco and Sherman Oaks Notre Dame remain unbeaten in high school baseball

latimes.com logo
Mar 22 • 2:30 PM EDT • Sports • latimes.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

erictopol.substack.com logo
Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Kentucky vs. Iowa State odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Kentucky vs. Iowa State picks for the NCAA Tournament 2026 second-round game on Sunday

cbssports.com logo
Mar 22 • 1:03 PM EDT • Sports • cbssports.com
Deep dive
😐 Neutral (7%)
wow
46%
ahah
31%
love
23%
Everything you need to know about the ‘Hannah Montana 20th Anniversary Special’ — How to watch, premiere time, who’s coming back and more

Sweet niblets! Hannah Montana is back for an anniversary special. Here's what to know.

yahoo.com logo
Mar 22 • 12:00 PM EDT • Entertainment • yahoo.com
You're Incredibly Smart If You Can Answer Even ONE Question On This Science Quiz

It's time to channel your inner Bill Nye.

buzzfeed.com logo
Mar 22 • 11:31 AM EDT • Science • buzzfeed.com
Arsenal vs. Manchester City live stream: How to watch EFL Cup final, odds, start time

This is Pep Guardiola's best chance at a trophy this season, and perhaps shift the momentum in the Premier League

cbssports.com logo
Mar 22 • 11:09 AM EDT • Sports • cbssports.com
This CEO took legal advice from ChatGPT to avoid paying $250 million bonus. It backfired

The court stressed that company executives are expected to exercise independent judgment, not outsource good-faith decisions to an AI.

hindustantimes.com logo
Mar 22 • 10:57 AM EDT • Technology • hindustantimes.com
Treasury secretary defends U.S. military actions in Iran: 'Sometimes you have to escalate to de-escalate'

Scott Bessent said "all options" were on the table to secure Kharg Island.

nbcnews.com logo
Mar 22 • 10:30 AM EDT • Politics • nbcnews.com
High-Signal Publisher
American football takes for ever. In which other sports do you spend most of your time not playing the game?

The long-running series in which readers answer other readers’ questions on subjects ranging from trivial flights of fancy to profound scientific and philosophical concepts

theguardian.com logo
Mar 22 • 10:00 AM EDT • Sports • theguardian.com
😐 Neutral (0%)
love
40%
wow
40%
sad
20%
It’s time to take politics out of the Small Business Administration

The White House’s politicization of the agency will have a real-world impact on small business owners in the US

theguardian.com logo
Mar 22 • 10:00 AM EDT • Business • theguardian.com
Deep dive
😐 Neutral (6%)
ahah
54%
wow
46%
It’s time to take politics out of the Small Business Administration

The White House’s politicization of the agency will have a real-world impact on small business owners in the US

theguardian.com logo
Mar 22 • 10:00 AM EDT • Politics • theguardian.com
Deep dive
😐 Neutral (6%)
ahah
54%
wow
46%
Drew Barrymore says talk show audience member once criticized her dating profile

Drew Barrymore is remembering the time an audience member on her talk show gave his honest thoughts about her dating profile: 'I would probably run away.'

ew.com logo
Mar 22 • 9:30 AM EDT • Entertainment • ew.com
It's not just vaccines — parents are refusing other routine preventive care for newborns

Doctors are alarmed that skepticism fueled by rising anti-science sentiment is increasingly reaching beyond vaccines to other proven, routine, preventive care for babies.

boston.com logo
Mar 22 • 9:26 AM EDT • Health • boston.com
Deep dive
😐 Neutral (11%)
love
56%
wow
44%
This floating time crystal breaks Newton’s third law of motion

Scientists have created a new kind of time crystal using sound waves to levitate tiny beads in mid-air. These particles interact in a one-sided, unbalanced way, breaking the usual rules of motion and creating a steady, repeating rhythm. The system is surprisingly simple yet reveals complex physics with big implications. It could help advance quantum computing and deepen our understanding of biological timing systems.

sciencedaily.com logo
Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
How my time at Goldman is giving me a leg up building a cake business

Allison Sheehan left Goldman Sachs to build her "cake empire," but said her time on Wall Street has taught her crucial skills.

businessinsider.com logo
Mar 22 • 7:53 AM EDT • Business • businessinsider.com
🙂 Positive (50%)
I left Goldman Sachs to build a small baking business. Here's how my time at the firm is giving me a leg up.
yahoo.com logo
Mar 22 • 7:53 AM EDT • Business • yahoo.com
Boys' basketball coach of the year: Mike LeDuc of Damien

The second-winningest coach in California high school history guided Damien to the state Division I championship.

latimes.com logo
Mar 22 • 7:10 AM EDT • Sports • latimes.com
Girls' basketball coach of the year: Alicia Komaki of Sierra Canyon

She came up with a winning formula to defeat Etiwanda and No. 1 Ontario Christian in the Southern Section Open Division championship.

latimes.com logo
Mar 22 • 7:00 AM EDT • Sports • latimes.com
We Took Our Three-Year-Old On A Long Haul Flight, And It Was Amazing!

We took our three year old on his first long haul flight in nearly two years. It went so much better than I could have anticipated!

onemileatatime.com logo
Mar 22 • 6:50 AM EDT • Technology • onemileatatime.com
The Times' 2025-26 All-Star boys' basketball team

A look at the Los Angeles Times' 10-member All-Star boys' basketball team for the 2025-26 season.

latimes.com logo
Mar 22 • 6:40 AM EDT • Sports • latimes.com
The Times' final top 25 high school boys' basketball rankings

Sierra Canyon, the state Open Division champion, finishes No. 1 in The Times' final 2025-26 high school boys' basketball rankings.

latimes.com logo
Mar 22 • 6:30 AM EDT • Sports • latimes.com
Southland girls' basketball final rankings for 2025-26 seaosn

A look at the top 20 high school girls' basketball teams in the Southland, led by Open Division state champion Ontario Christian.

latimes.com logo
Mar 22 • 6:05 AM EDT • Sports • latimes.com
Four truths about covid that have become clouded over time

In the early days, the virus posed a graver threat to people and the health care system, Trump embraced lockdowns he now blasts, and the benefits of vaccines were oversold.

washingtonpost.com logo
Mar 22 • 6:00 AM EDT • Health • washingtonpost.com
Column: Republicans fearing a midterm rout revive Islamophobia as political strategy

The latest twist on replacement theory is the idea that white Americans are in need of saving from dark-skinned "others."

latimes.com logo
Mar 22 • 6:00 AM EDT • Politics • latimes.com
Outgoing MSPs leave Holyrood with relief, regret and unfinished business

A record 42 MSPs are stepping down, from grandees to first timers - they share their reasons why.

bbc.com logo
Mar 22 • 5:16 AM EDT • Business • bbc.com
Deep dive
😐 Neutral (11%)
wow
55%
ahah
45%
Where to watch Minnesota vs. Ole Miss in March Madness Second Round: Time, TV Channel

The No. 4 Minnesota Golden Gophers face the 5 Ole Miss Rebels in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

usatoday.com logo
Mar 22 • 5:06 AM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (6%)
wow
54%
love
46%
Where to watch Duke vs. Baylor in March Madness Second Round: Time, TV Channel

The No. 3 Duke Blue Devils face the 6 Baylor Bears in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

usatoday.com logo
Mar 22 • 5:06 AM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (5%)
wow
54%
love
46%
Where to watch Oklahoma vs. Michigan State in March Madness Second Round: Time, TV Channel

The No. 4 Oklahoma Sooners face the 5 Michigan State Spartans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

usatoday.com logo
Mar 22 • 5:06 AM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (6%)
wow
54%
love
46%
'Love Story' is Gen Z's analog dream life

The unplugged lives in "Love Story" feel remarkable to Gen Zers today. They're nostalgic for a time they don't even remember.

businessinsider.com logo
Mar 22 • 5:01 AM EDT • Business • businessinsider.com
The Supreme Court Could Make it Harder to Vote by Mail in the Midterms

The Republican National Committee wants to toss ballots arriving after Election Day. Critics say thousands of votes — a majority cast by Democrats — are at stake.

nytimes.com logo
Mar 22 • 5:00 AM EDT • Politics • nytimes.com
What time is Michigan women's basketball's second round game?

Michigan cruised to a blowout victory over Holy Cross in their opening NCAA Women's Tournament matchup. See who they play next.

sports.yahoo.com logo
Mar 22 • 4:46 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-4%)
ahah
25%
love
25%
sad
25%
David Suzuki at 90: A life in science, and a warning still unheard

With ninety laps around the sun, David Suzuki reflects on a lifetime of science advocacy and environmental work. Despite decades of effort, he warns that humanity may have already crossed a tipping point on climate change.

cbc.ca logo
Mar 22 • 4:00 AM EDT • Science • cbc.ca
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed

A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.

spokesman.com logo
Mar 22 • 3:16 AM EDT • Sports • spokesman.com
Paxton Aaronson scores twice to propel Rapids to 4-1 victory over Sporting KC

Paxton Aaronson scored a goal in each half, Wayne Frederick's first career goal was the go-ahead score and the Colorado Rapids rolled to a 4-1 victory over Sporting Kansas City on Saturday night. Aaronson gave Colorado (3-2-0) the lead in the 12th minute, but Shapi Suleymanov scored for the first time this season — in the 44th — to pull Sporting KC (1-3-1) even. The tie lasted until the second minute of stoppage time when Frederick scored unassisted for a 2-1 lead at halftime.

sports.yahoo.com logo
Mar 22 • 1:40 AM EDT • Sports • sports.yahoo.com
😐 Neutral (8%)
love
71%
wow
29%
Election in Slovenia Will Test Europe’s Political Mood

The center-left government is being challenged by a right-wing populist accused of launching a smear campaign in the final days of a close race.

nytimes.com logo
Mar 22 • 12:01 AM EDT • Politics • nytimes.com
France Is Voting for Thousands of New Mayors. Here’s Why It Matters.

The far-right party had first-round successes in several cities, but so did the far left. Sunday’s second round may clarify who has real momentum.

nytimes.com logo
Mar 22 • 12:01 AM EDT • Politics • nytimes.com
As War Disrupts India’s Gulf Ties, Economy Faces ‘New Broadside’

Generations of Indian workers and businesses have turned the Arab side of the Gulf into a vital appendage of their own country.

nytimes.com logo
Mar 22 • 12:00 AM EDT • Business • nytimes.com
Today's NYT Connections: Sports Edition Hints, Answers for March 22 #545

Here's today's Connections: Sports Edition answer and hints for groups. These clues will help you solve The New York Times' popular puzzle game, Connections: Sports Edition, every day.

cnet.com logo
Mar 21 • 11:13 PM EDT • Sports • cnet.com
High school baseball and softball: Saturday's scores

CIF City Section and Southern Section high school baseball and softball scores for Saturday's games.

latimes.com logo
Mar 21 • 11:06 PM EDT • Sports • latimes.com
Digimon Story: Time Stranger large-scale expansion DLC announced

Publisher Bandai Namco and developer Media.Vision have announced a large-scale expansion downloadable content for Digimon Story: Time Stranger. It will launch in 2027.

gematsu.com logo
Mar 21 • 10:52 PM EDT • Technology • gematsu.com
Beshear Criticizes Vance in Ohio, Stoking 2028 Presidential Tensions

Mr. Beshear, the Democratic governor of Kentucky, sharply criticized Mr. Vance as both angle for potential presidential runs.

nytimes.com logo
Mar 21 • 10:21 PM EDT • Politics • nytimes.com
Trump’s Reaction to Mueller’s Death: ‘Good, I’m Glad.’

The president has consistently celebrated the deaths of political foes. His response to Mr. Mueller’s death drew criticism from Republicans and Democrats.

nytimes.com logo
Mar 21 • 9:41 PM EDT • Politics • nytimes.com
Clemson's Mia Moore and USC's Kara Dunn renew rivalry in overtime thriller

Moore and Dunn both grew up near Atlanta, and first matched up in middle school. They also played AAU together in high school.

usatoday.com logo
Mar 21 • 8:31 PM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (9%)
wow
42%
love
33%
ahah
25%
March heat wave draws Coloradans to the water, boosts seasonal business

A historic March heat wave sweeping across Colorado is sending residents outdoors in search of relief, with many trading winter sports for time on the water.

kdvr.com logo
Mar 21 • 7:19 PM EDT • Business • kdvr.com
"Derby of the dead child": This match changed football forever

When does a game become legendary? Is it when everyone can remember where they were at the time of the match? When the game has its own Wikipedia article? When the game marks a turning point in footba...

sports.yahoo.com logo
Mar 21 • 6:53 PM EDT • Sports • sports.yahoo.com
G.O.P. Bid to Target Transgender Athletes Falls Flat in the Senate

In moving to bar transgender women and girls from women’s and girls’ sports, Republicans sought to put Democrats in an awkward political spot on a sensitive issue ahead of the midterm elections.

nytimes.com logo
Mar 21 • 4:56 PM EDT • Politics • nytimes.com
Sony PlayStation Network down: PS5 users report widespread server issues; 'please fix it'

Sony PlayStation Network appeared to be down for thousands on Saturday as many flocked to social media to voice their complaints. | World News

hindustantimes.com logo
Mar 21 • 4:35 PM EDT • Technology • hindustantimes.com
March Madness scores: Live updates, schedule for today's NCAA Round 2

Keep up with today's Men's NCAA Tournament second round with scores, highlights, game times and how to watch March Madness Round 2.

usatoday.com logo
Mar 21 • 4:15 PM EDT • Sports • usatoday.com
Deep dive
😐 Neutral (12%)
love
59%
wow
41%
ESP32: When Is A P4 A P4, But Not The P4 You Thought It Was

We’re used to electronic parts of the same type staying predictably the same, sometimes over many years. An early Z80 from the mid 1970s can be exchanged with one from the end of production a…

hackaday.com logo
Mar 21 • 4:00 PM EDT • Technology • hackaday.com
Dueling Complaints Alleging Open Meeting Law Violations Emerge After…

Nantucket Current is the island's leading online news source. We deliver the news, stories, and people of Nantucket, unbiased and unfiltered.

nantucketcurrent.com logo
Mar 21 • 4:00 PM EDT • Health • nantucketcurrent.com
Deep dive
😐 Neutral (-1%)
love
39%
wow
33%
ahah
28%
Trump Is Finally Eyeing an Exit From Iran. But Will He Take It?

President Trump says he is considering “winding down” operations in Iran. But many of his original war goals remain unaccomplished.

nytimes.com logo
Mar 21 • 3:29 PM EDT • Politics • nytimes.com
Robert Mueller, former special counsel who led Trump-Russia probe, dies

A decorated Marine and longtime law enforcement leader, Mueller served as FBI director before taking on the high-profile investigation in 2017.

nbcnews.com logo
Mar 21 • 2:19 PM EDT • Politics • nbcnews.com
High-Signal Publisher
County seeks public input on behavioral health services plan

San Diego County health officials were seeking public input Saturday on how best to provide behavioral health services to county residents.

timesofsandiego.com logo
Mar 21 • 2:04 PM EDT • Health • timesofsandiego.com