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Revolutionary Women: Lady Johnson, Angelica Schuyler and the Politics of Loyalty

State and territory commissions and other partners are hosting events across the nation to commemorate America's 250 anniversary in 2026.

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Mar 23 • 7:24 PM EDT • Politics • america250.org
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Playoff-bound Wild, Lightning out to improve positioning

The Minnesota Wild and Tampa Bay Lightning, two powerhouses preparing for the playoffs in their respective conferences, will complete their two-game season series in Tuesday night's matchup in the Sunshine State.

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Mar 23 • 7:21 PM EDT • Sports • cbssports.com
SC sees historical ranking in a 2025 national health ranking

South Carolina came in at 36th in the United Health Foundation's America Health Rankings 2025 annual report, the state’s best ranking since the report started b

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Mar 23 • 6:26 PM EDT • Health • abcnews4.com
Group abandons Michigan minimum wage ballot campaign

A group seeking to reverse changes the state Legislature made last year to Michigan's tipped and minimum wage laws is abandoning its efforts for now.

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Mar 23 • 5:52 PM EDT • Politics • detroitnews.com
After patient deaths, Idaho budget committee approves restoring cut Medicaid mental health programs

The Idaho Legislature will consider restoring mental health programs the state cut to comply with the governor’s order for budget cuts.

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Mar 23 • 5:34 PM EDT • Health • idahocapitalsun.com
Democratic and Republican Party officials face internal backlash after primaries

Party officials have received calls to resign amid endorsements and campaign spending in national and state primary elections.

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Mar 23 • 5:12 PM EDT • Politics • newsobserver.com
Task force delves into fiscal future of Florida college sports

State university leaders kicked off efforts Monday to ensure college sports in Florida is competitive and sustainable amid the rapidly changing landscape of collegiate athletics.

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Mar 23 • 4:52 PM EDT • Sports • nbcmiami.com
Randy Bennett agrees to take ASU basketball job

Randy Bennett is returning to the Valley as the Arizona State men's basketball coach after leading Saint Mary's for the last 25 years.

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Mar 23 • 4:34 PM EDT • Sports • arizonasports.com
Louisiana's health secretary wants AI on the phones and the website

Louisiana residents may see changes in calling the state health department or using its website if it turns to artificial intelligence to save money. The department is examining how it can implement AI over the next few years to make residents’ experiences more efficient and reduce spending, Louisiana Department of Health Secretary Bruce Greenstein said […]

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Mar 23 • 4:14 PM EDT • Health • businessreport.com
Cincinnati hires Jerrod Calhoun: Utah State coach leaving after two years to guide his alma mater

The Bearcats have agreed to a six-year deal with the 44-year-old coach, a source told CBS Sports

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Mar 23 • 4:02 PM EDT • Sports • cbssports.com
NMSU’s ‘Big Bang Bash’ invites community to hands-on art and science experience

New Mexico State University’s College of Arts and Sciences welcomes kids of all ages to this year’s “Big Bang Bash: Where Arts and Sciences Collide” from 5:30 to 8:30 p.m. Thursday, April 2 at...

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Mar 23 • 3:48 PM EDT • Science • newsroom.nmsu.edu
Takeaways from arguments in the Supreme Court case that could end grace periods for mail-in ballots

The Supreme Court’s conservative majority appeared dubious of state laws that allow the counting of mail ballots that arrive at election offices after Election Day as justices heard oral arguments in a challenge to Mississippi’s five-day grace period for mail ballots.

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Mar 23 • 3:46 PM EDT • Politics • cnn.com
Federal judge sides with Wisconsin in transgender health care suit

A U.S. judge ruled in favor of Wisconsin and 20 other states challenging a Trump administration declaration that tried to limit care for trans youth.

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Mar 23 • 3:23 PM EDT • Health • jsonline.com
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Trump administration adds State Health Officer Dr. Daniel Edney to short list of nominees for CDC director

State Health Officer Dr. Dan Edney is among the contenders to head the nation’s Centers for Disease Control and Prevention, the Washington Post reported

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Mar 23 • 2:25 PM EDT • Health • mississippitoday.org
AI attack ads are hitting Massachusetts political campaigns

Lawmakers are considering new legislation to regulate the use of AI in political advertising. Have you spotted them?

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Mar 23 • 2:18 PM EDT • Politics • boston.com
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Uplifting and Not Ceding Ground on Health Equity Practice Is Critical to Strengthening Public Health and the Health of the Nation

Public health science gains in the last quarter century in the United States have been formidable due to a focus on structural and social determinants of health, thereby enhancing understanding of the role of inequitable policies in shaping health inequities and inequitable access to ameliorative resources.

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Mar 23 • 1:54 PM EDT • Health • milbank.org
SCOTUS conservatives signal readiness to curb late-arriving mail ballots

Conservative Supreme Court justices appeared skeptical during oral arguments of allowing states to continue counting late-arriving mail-in ballots. A decision is expected in June.

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Mar 23 • 1:52 PM EDT • Politics • foxnews.com
Bipartisan Senate bill would ban sports betting on online prediction markets

Bill was introduced in the Senate on Monday as prediction market companies face greater scrutiny on state level

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Mar 23 • 12:53 PM EDT • Sports • theguardian.com
Supreme Court hears arguments in mail-in voting case

The Supreme Court is hearing arguments today in a case about whether states may count mail-in ballots received after Election Day. Follow here for live updates.

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Mar 23 • 9:36 AM EDT • Politics • cnn.com
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Prisco's 2026 NFL mock draft 1.0: Four of top five picks on defensive side, Browns select QB

Teams at top of the draft opt for pass rush over offense.

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Mar 23 • 9:20 AM EDT • Sports • cbssports.com
Marquette Law School adds Aaron Hernandez to National Sports Law Institute leadership

Aaron Hernandez, currently at Arizona State University’s Sandra Day O’Connor College of Law, will be joining the faculty at Marquette University Law School as associate professor of practice and director of the National Sports Law Institute. Marquette is led in the area of sports law by Matt Mitten, professor of law, and Paul Anderson, associate…

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Mar 23 • 9:00 AM EDT • Sports • today.marquette.edu
As President Trump’s Attacks on Science Escalate, Big Oil Moves to Avoid Legal Accountability

This piece was originally published in Climate Home News. The Supreme Court of the United States (SCOTUS) recently agreed to hear arguments in Boulder v. Exxon and Suncor a case that could decide whether communities harmed by climate change can hold polluters accountable in state court. Origin

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Mar 23 • 8:00 AM EDT • Science • blog.ucs.org
Grub Lab: $6 Million Raised To Bring Sports And Entertainment IP To Independent Restaurants Nationwide

Grub Lab, an Australia-founded restaurant technology startup, announced it has raised $6 million in funding from Quantaco to accelerate its expansion across the United States and support a national rollout tied to major sports leagues and entertainment studios. The company is positioning itself as a modern solution to help independent restaurants compete for family dining traffic through interactive, branded experiences.

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Mar 23 • 7:54 AM EDT • Entertainment • pulse2.com
Ohio lawmaker proposes election board changes after Delaware County dispute

Dispute at the Delaware County Board of Elections prompted a state lawmaker to propose changes to how county election boards work.

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Mar 23 • 6:03 AM EDT • Politics • dispatch.com
Data centers under scrutiny by California lawmakers as fears rise about health and energy impacts

Due to health and energy concerns, the California Legislature is considering bills to prohibit data centers from being exempted from the state's stringent environmental law and impose new tariffs on new major energy users that strain power supplies.

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Mar 23 • 6:00 AM EDT • Health • latimes.com
MTSU Agrees to Long-Term Extension with NIKE and BSN SPORTS - Middle Tennessee State University Athletics

MTSU Athletics announced on Monday that it will continue to partner with the world's leading brand for apparel and footwear after inking a long-term extensio...

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Mar 23 • 6:00 AM EDT • Sports • goblueraiders.com
Scouting Michigan State basketball Sweet 16 matchup with UConn

Get a first glimpse at the NCAA Tournament East region Sweet 16 semifinal matchup between 3-seed Michigan State basketball and 2-seed UConn.

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Mar 23 • 5:09 AM EDT • Sports • freep.com
Ohio State vs Notre Dame predictions, picks, odds for NCAA Tournament Second Round

Our March Madness experts pick the winner for No. 3 Ohio State vs No. 6 Notre Dame in the 2026 women's NCAA Tournament on March 23

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Mar 23 • 5:08 AM EDT • Sports • usatoday.com
Coeur d'Alene's science guy

Ahead of his retirement in May from the teaching staff at Arizona State University, behavioral neuroscientist Brian Smith has put his focus into making science more accessible to more people. “There's a lot of misunderstanding what science is,” Smith said.

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Mar 23 • 4:08 AM EDT • Science • cdapress.com
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St. Louis Blues Weekly Prospect Report (March 22)

Jiricek has big scoring week; McIsaac announces future plans; Ralph, Michigan State head to NCAA Tournament with Mayich, Clarkson University eliminated; Peterson scored pair, including a SH beauty for Springfield

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Mar 23 • 12:54 AM EDT • Sports • sports.yahoo.com
NCAA, NIT, WBIT tournaments lead to uptick in business for Wichita bars

Fans of KU, K-State and WSU flocked to sports bars to cheer on their favorite teams.

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Mar 23 • 12:17 AM EDT • Business • kwch.com
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State lawmakers debate new round of business tax cuts

Rep. Joe Sweeney, R-Salem, and Sen. Donovan Fenton, D-Keene, discussed their support and opposition to House Bill 155, which would reduce the business enterprise tax from 0.55% to 0.50%.

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Mar 22 • 11:27 PM EDT • Business • wmur.com
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Wichita State wins 96-70 against Oklahoma State in NIT

STILLWATER, Okla. (AP) Kenyon Giles had 28 points in Wichita State's 96-70 victory against Oklahoma State on Sunday in the NIT.

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Mar 22 • 11:19 PM EDT • Sports • cbssports.com
Michigan State basketball time, TV channel set for Sweet 16

Michigan State basketball knows when it will be playing, even before it knows its opponent in the Sweet 16 in Washington on Friday night.

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Mar 22 • 11:05 PM EDT • Sports • sports.yahoo.com
Simona Martin: Colorado’s data center boom needs public health guardrails

As AI infrastructure expands across the state, lawmakers face a choice about who bears the costs and risks.

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Mar 22 • 11:00 PM EDT • Health • boulderreportinglab.org
No. 1 Arizona takes care of business against No. 9 Utah State to advance to Sweet 16
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Mar 22 • 10:32 PM EDT • Business • sports.yahoo.com
No. 1 Arizona takes care of business against No. 9 Utah State to advance to Sweet 16
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Mar 22 • 10:32 PM EDT • Sports • sports.yahoo.com
Vermont may look across borders to help bring in business

House passes bill to create sister state program for economic development.

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Mar 22 • 8:55 PM EDT • Business • wcax.com
Jerry Hanlon, longtime Michigan football coach, dies at 96

"Michigan Athletics has lost one of the finest ambassadors and mentors our football program has ever known," U-M AD Warde Manuel said in a statement.

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Mar 22 • 8:34 PM EDT • Sports • sports.yahoo.com
Binghamton ranked No. 1 public business school in New York state

The Binghamton University School of Management jumped ahead in the prominent Best Undergraduate Business Schools of 2026 ranking by Poets & Quants, placing No. 1 among New York state’s public business schools.

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Mar 22 • 8:00 PM EDT • Business • binghamton.edu
Wisconsin edges Ohio St., wins another title at Frozen Four

Claire Enright scored the go-ahead goal in the third period Sunday, Ava McNaughton had 34 saves, and No. 2 seed Wisconsin beat top-seeded Ohio State 3-2 at the Frozen Four to win its second consecutive national championship.

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Mar 22 • 7:21 PM EDT • Sports • espn.com
Students compete in Virginia Science Olympiad State Tournament at UVA

The tournament’s events ranged from knowledge tests to building robots.

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Mar 22 • 6:22 PM EDT • Science • 29news.com
Students compete in Virginia Science Olympiad State Tournament at UVA

The tournament’s events ranged from knowledge tests to building robots.

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Mar 22 • 6:22 PM EDT • Science • whsv.com
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Sunday Sports: Sackets hoops in the state finals, plus updates on SU sports

Here’s a recap of your North Country sports this Sunday.

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Mar 22 • 6:20 PM EDT • Sports • wwnytv.com
Crews responding to fire burning behind an Upstate business

Multiple fire departments responded to a fire behind the Tractor Supply Co. in Mauldin, SC.

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Mar 22 • 5:25 PM EDT • Business • wyff4.com
Arizona vs Utah State live updates: Prediction, how to watch March Madness Round 2 game

Folks were gushing about Jerrod Calhoun and Utah State's offense in Round 1. Arizona is a whole different obstacle. Follow March Madness Round 2 game.

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Mar 22 • 4:05 PM EDT • Sports • usatoday.com
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Educational Service Center awarded Teach Computer Science 2.0 Grant

The Educational Service Center of the Western Reserve has been awarded $584,614 through the Ohio Teach Computer Science 2.0 State Grant, a competitive initiative funded by the Ohio Department of Higher Education. As part of an $8 million…

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Mar 22 • 4:00 PM EDT • Science • news-herald.com
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Exit polls suggest lead for Merz's SPD in key west German state

Far-right Alternative for Germany party (AfD) looks set for a record score in western Germany

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Mar 22 • 3:52 PM EDT • Politics • euractiv.com
Student researchers bring Kentucky State University science to Posters-at-the-Capitol

With lawmakers just steps away, three Kentucky State University undergraduates presented research on cattle health, soil amendments and food safety at the Capitol Annex on March 5, bringing student-led agricultural […]

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Mar 22 • 3:00 PM EDT • Science • state-journal.com
Kentucky Gov. Beshear takes jabs at JD Vance in his home state of Ohio

Kentucky Gov. Andy Beshear, speaking in JD Vance’s home state of Ohio on Saturday, tore into the vice president, questioning his Appalachian roots and telling voters they “deserve better.”

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Mar 22 • 2:44 PM EDT • Politics • cnn.com
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Nevada Wins Temporary Ban on Sports Betting on Kalshi

The prediction-market platform must obtain state gambling licenses and prohibit users under 21 to offer such contracts, a state court said.

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Mar 22 • 2:40 PM EDT • Sports • wsj.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Southern Living names top small towns, Florida snags 5 spots

St. Augustine named best small town in the Southern United States.

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Mar 22 • 1:46 PM EDT • Politics • floridapolitics.com
Mississippi State Health Officer Dr. Daniel Edney, a Vaccine Proponent, Is Under Consideration to Lead the CDC

Dr. Daniel P. Edney, Mississippi’s state health officer and head of the Mississippi State Department of Health, is now under serious consideration to lead the CDC.

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Mar 22 • 1:10 PM EDT • Health • mississippifreepress.org
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Kentucky vs. Iowa State odds, time, March Madness predictions: 2026 NCAA Tournament picks from proven model

SportsLine's model has revealed its Kentucky vs. Iowa State picks for the NCAA Tournament 2026 second-round game on Sunday

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Mar 22 • 1:03 PM EDT • Sports • cbssports.com
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Top 5 states with the highest number of safe hospitals, according to new report
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Mar 22 • 12:27 PM EDT • Health • nypost.com
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Tom Steyer explains why he should be California's next governor

Tom Steyer sat down for an interview with California Politics 360 for a wide-ranging conversation on his run to be the state's next governor.

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Mar 22 • 11:25 AM EDT • Politics • kcra.com
California sheriff seizes 650,000 ballots in defiance of state officials over election count dispute

Riverside County Sheriff Chad Bianco seized over 650,000 ballots to probe alleged excess votes in California's Proposition 50 special election.

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Mar 22 • 10:48 AM EDT • Politics • foxnews.com
The best seafood restaurant in every state, according to Yelp

Yelp picked the best seafood restaurant in every state based on customer reviews.

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Mar 22 • 9:19 AM EDT • Business • businessinsider.com
Scientists twisted a mysterious superconductor and got a shocking result

A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.

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Mar 22 • 8:00 AM EDT • Science • sciencedaily.com
Neighbors say Indian Springs revival could do KCK ‘more good than that stadium’

Area businesses said they want to see the project revitalize the State Avenue business corridor near I-635.

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Mar 22 • 7:20 AM EDT • Business • kansascity.com
Boys' basketball coach of the year: Mike LeDuc of Damien

The second-winningest coach in California high school history guided Damien to the state Division I championship.

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Mar 22 • 7:10 AM EDT • Sports • latimes.com
Lancaster County public sales: March 22, 2026

Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and

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Mar 22 • 7:00 AM EDT • Business • lancasteronline.com
The Times' final top 25 high school boys' basketball rankings

Sierra Canyon, the state Open Division champion, finishes No. 1 in The Times' final 2025-26 high school boys' basketball rankings.

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Mar 22 • 6:30 AM EDT • Sports • latimes.com
Southland girls' basketball final rankings for 2025-26 seaosn

A look at the top 20 high school girls' basketball teams in the Southland, led by Open Division state champion Ontario Christian.

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Mar 22 • 6:05 AM EDT • Sports • latimes.com
Can future astronauts be put into comas for space travel like in Project Hail Mary?

The science-fiction film Project Hail Mary sees Ryan Gosling go to space in a state of suspended animation. But does the science suggest that’s possible?

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Mar 22 • 6:00 AM EDT • Science • scientificamerican.com
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AI-generated ads are trickling into political campaigns, sparking big worries

AI usage in political ads is largely regulated at the state level, but there remain concerns about how they can mislead voters.

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Mar 22 • 6:00 AM EDT • Politics • nbcnews.com
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How investors use the BRRRR strategy to scale real estate portfolios

"My strategy is basically to use every property to fund the next one," said one real estate investor.

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Mar 22 • 5:30 AM EDT • Business • businessinsider.com
Where to watch Oklahoma vs. Michigan State in March Madness Second Round: Time, TV Channel

The No. 4 Oklahoma Sooners face the 5 Michigan State Spartans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.

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Mar 22 • 5:06 AM EDT • Sports • usatoday.com
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Alaska Sports Scoreboard: March 21, 2026

Scores and results from competitions across the state.

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Mar 22 • 2:16 AM EDT • Sports • adn.com
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Marc Abrahams, founder of the satirical Ig Nobel Prizes: ‘Scientists in the US are very angry. People are waking up’

The awards are moving to Switzerland, because their founder believes he can no longer guarantee the laureates’ safety in the United States

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Mar 22 • 12:00 AM EDT • Science • english.elpais.com
GALLERY: Moments from Iowa State’s 9-7 win over Houston

GALLERY: Moments from Iowa State’s 9-7 win over Houston

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Mar 21 • 11:50 PM EDT • Sports • sports.yahoo.com
Mt. Vernon withstands 'nightmare' scenario, punches ticket to state finals

Luke Ertel was on the bench with four fouls as Mt. Vernon's lead slipped. He returned to help Marauders punch ticket to state.

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Mar 21 • 11:41 PM EDT • Sports • sports.yahoo.com
Former OSU athletes talk mental health at Scioto County Mindset Matters Summit

Big names like former Ohio State Point Guard Scoonie Penn, Heisman Trophy winner Troy Smith, former Buckeye Bobby Carpenter, taking the stage at the event to talk with our very own Joseph Payton about mental health.

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Mar 21 • 10:15 PM EDT • Health • wsaz.com
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Warriors' Stephen Curry set for major checkpoint in injury recovery

According to Steve Kerr, Golden State Warriors star, Stephen Curry will participated in a scrimmage on Sunday, March 22.

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Mar 21 • 8:30 PM EDT • Sports • sports.yahoo.com
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Goodrich polishes off perfect season with MHSAA girls basketball title

Goodrich beat Tecumseh, 55-44, in the MHSAA girls basketball Division 2 state championship on Saturday, March 21 in East Lansing.

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Mar 21 • 8:24 PM EDT • Sports • freep.com
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Washington Football Hires Utah State Analyst as Special Teams Analyst

Washington will once again have two coaches working on specials teams in 2026 after added a rising analyst to work alongside Chris Petrilli.

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Mar 21 • 8:00 PM EDT • Sports • sports.yahoo.com
More school-based health clinics fill growing needs

An increase in school-based health clinics is sweeping the states of Ohio and Michigan, following research that grounds positive health outcomes for ...

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Mar 21 • 8:00 PM EDT • Health • toledoblade.com
March Madness live updates, scores: No. 3 Gonzaga battling No. 11 Texas; Duke, Michigan, Michigan State bound for Sweet 16
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Mar 21 • 7:55 PM EDT • Sports • sports.yahoo.com
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Warriors provide exciting injury update on Moses Moody

The Golden State Warriors have provided an exciting injury update on Moses Moody

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Mar 21 • 7:19 PM EDT • Sports • sports.yahoo.com
Four-star forward Joe Philon commits to UCLA

Joe Philon, a four-star power forward in the 2026 class, has committed to UCLA, he told On3. The 6-foot-8 senior out of Montverde Academy (FL) chose the Bruins after considering Ohio State, South Florida, UNLV, and Xavier. Philon, a native of Tampa, Florida, is the No. 56 overall player in the 2026 class, according to […]

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Mar 21 • 6:54 PM EDT • Sports • sports.yahoo.com
Illinois State, Wake Forest battle for NIT quarterfinal spot

Another prolific scoring performance by Juke Harris allowed Wake Forest to keep its season alive and the best game of Landon Wolf's career enabled Illinois State to continue playing.

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Mar 21 • 5:42 PM EDT • Sports • cbssports.com
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March Madness live updates, scores: No. 1 Duke takes on No. 9 TCU; Michigan State, Michigan bound for Sweet 16
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Mar 21 • 5:16 PM EDT • Sports • sports.yahoo.com
Top 5 states with the highest number of safest hospitals, according to new report

Healthgrades named 438 hospitals across 40 states for its 2026 Patient Safety Excellence Award, with Texas and Florida among the top-performing states.

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Mar 21 • 4:25 PM EDT • Health • foxnews.com
Jaebri'an Autry ends Detroit Renaissance career with heartbreak

Muskegon beat Detroit Renaissance 34-29 in the MHSAA girls basketball Division 1 state championship game on Saturday, March 21 in East Lansing.

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Mar 21 • 4:00 PM EDT • Sports • freep.com
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March Madness bracket live updates, scores: No. 3 Michigan State takes on No. 6 Louisville; Michigan routs Saint Louis
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Mar 21 • 2:45 PM EDT • Sports • sports.yahoo.com
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Gov. Stein announces $8.5 million for WNC small business recovery after Helene

The funding will assist 13 projects through the North Carolina Department of Commerce’s Small Business Infrastructure Grant Program, continuing the state’s response to the impacts of Hurricane Helene.

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Mar 21 • 2:30 PM EDT • Business • foxcarolina.com
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Robert Mueller, former FBI director and special counsel in Trump-Russia probe, dies

Robert Mueller, the former FBI director who led the historic probe into alleged collusion between Donald Trump’s 2016 campaign and the Russian government, has died, according to a family statement obtained by The New York Times and the Associated Press. He was 81.

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Mar 21 • 1:44 PM EDT • Politics • cnn.com
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Former FBI chief, Robert Mueller, dead at 81

Robert Mueller oversaw the probe into alleged Russian interference in the 2016 United States election.

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Mar 21 • 1:42 PM EDT • Politics • aljazeera.com
Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout

Spanberger will mull theirs and former Gov. Glenn Youngkin’s budget proposals ahead of a reconvened session on April 23.

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Mar 21 • 1:10 PM EDT • Health • wtop.com
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NCDHHS launches new program looking to expand number of mental health providers in state

In North Carolina, the demand for social workers in the state is growing as substance use and mental health service needs increase. The North Carolina Department of Health and Human Services launched the Public Service Leadership Program, a collaboration between the NCDHHS and 25 higher education institutions in the Social Work Coalition on NC Work Development, to help with that demand.Alongside the announcement of the new program on March 2, the NCDHHS released its first “State of North Carolina’s Mental Health and Substance Use Services Workforce Report” supported by UNC’s Behavior Health Workforce Research Center and Sheps Health Workforce NC.

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Mar 21 • 12:53 PM EDT • Health • elonnewsnetwork.com
The light and darkness of the Kristaps Porziņģis Experience hits the Warriors

The light and darkness of the Kristaps Porziņģis Experience has hit the Golden State Warriors after the big man exited Friday's game with back spasms.

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Mar 21 • 12:16 PM EDT • Sports • nbcsportsbayarea.com
What to know about Jaloni Cambridge, Ohio State's star in March Madness

Ohio State's Jaloni Cambridge makes her presence known in the paint and with pull-up jumpers. Here's what to know about her in the NCAA Tournament.

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Mar 21 • 9:27 AM EDT • Sports • usatoday.com
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March Madness games today: Ranking the 16-game Women's NCAA Tournament schedule for Saturday

Syracuse vs. Iowa State and Princeton vs. Oklahoma State leads the best Women's NCAA Tournament games to watch on Saturday.

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Mar 21 • 8:24 AM EDT • Sports • usatoday.com
Big money flows into state attorney general races as legal battles shape American politics

There are races in 30 states this year for attorney general, and groups that support those candidates prepared for the elections by raising record amounts in 2025.

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Mar 21 • 8:05 AM EDT • Politics • newsday.com
Big money flows into state attorney general races as legal battles shape American politics

There are races in 30 states this year for attorney general, and groups that support those candidates prepared for the elections by raising record amounts in 2025.

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Mar 21 • 8:05 AM EDT • Politics • ksat.com
Big Money Flows Into State Attorney General Races as Legal Battles Shape American Politics

With control of Congress on the ballot in November, state attorney general races can get lost in the shuffle. But just outside the election spotlight, there are partisan groups, corporate interests and advocacy networks revving up campaigns for offices that are playing a growing role in American ...

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Mar 21 • 8:05 AM EDT • Politics • usnews.com
Sign on shuttered Keizer store accuses Bricks & Minifigs of Lego theft

A dispute over what was once dubbed "one of the largest collections of Star Wars Lego figures in the world" led to a Keizer Police investigation.

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Mar 21 • 7:03 AM EDT • Business • statesmanjournal.com
'Not a done deal': Democrats start to sweat over Virginia's redistricting referendum

The unique nature of the April special election and the state's recent redistricting history have presented challenges for Democrats, even as they hold a financial edge in the race.

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Mar 21 • 5:00 AM EDT • Politics • nbcnews.com
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With casino empire gone, Trump family bets on prediction markets

With his Atlantic City casinos in duress in the 1990s, Donald Trump saw a potential lifeline in sports betting and aggressively campaigned to legalize it in New Jersey. But when state powerbrokers shut him down, Trump vowed that he’d eventually find a way to win.

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Mar 21 • 4:00 AM EDT • Politics • cnn.com