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Warriors' Draymond Green reveals 'ideal' outcome for upcoming free agency
It remains to be seen what the future holds from Draymond Green beyond the current campaign, but the veteran forward has an idea of how he would like it to go. Green recently laid out his “ideal” scenario for his NBA future, which would entail him declining his $27 million player option for the 2026-27 season in favor of a new extension to close out his career in Golden State. “Rich [Paul] and I discussed it a couple months ago briefly,” Green said.
Dani Olmo rejects lucrative €60m offer to leave Barcelona
The forward is not interested in moving on.
Neal Schon and bandmate Jonathan Cain battle lawsuits and politics as Journey's farewell tour rolls on
Journey bandmates Neal Schon and Jonathan Cain are feuding over politics, religion and lawsuits even as their farewell world tour moves forward.
Boozer recovering physically, emotionally from UConn loss
The Duke forward said Sunday that he suffered a “couple of fractures” during the Blue Devils' loss last week to UConn.
Bridging Political Divides: How faith can help find common ground
About 80% of American adults believe our political divides run so deep that we cannot even agree on basic facts, according to the Pew Research Center. But some Utah leaders say faith is helping them to find the common ground needed to bridge those political divides and find a new path forward.
Rangers track forward Gelhardt
Rangers could use 49ers connections to land Leeds striker and Hearts star on Portugal radar...
Democrats eye 2028 for bigger health care push
WASHINGTON – As Democrats vie to take control of Congress in the midterms this fall, their main message on health care policy is fairly straightforward: undo Republicans’ Medicaid cuts and restore the health care subsidies that lapsed at the end of last year.
Booming business: Miami’s secret side hustlers
Junior primary education major Georgia Palko worked at Bagel and Deli, but was looking for some extra cash. After calling her dad with a bright idea, she moved forward with her plan to sell sweet treats on Valentine's Day. With around $50 worth of strawberries, a college house kitchen and a side hustler mindset, she sold 300 strawberries to mothers and lovers.
The Push Forward | Presented by Atrium Health
The official website of Charlotte Football Club of Major League Soccer. Get the latest news, tickets, offers, player updates and more.
Sources: NBA investigating Bucks after Giannis says he's healthy
The NBA is investigating the Bucks' handling of Giannis Antetokounmpo, sources told ESPN's Shams Charania, after the star forward told reporters Friday that he is being held out despite being healthy enough to play.
Duke freshman forward Cameron Boozer named AP men's national player of the year
Boozer received 59 of 61 votes from AP Top 25 voters in results released Friday.
NHL Playoff Race: What the Penguins need to do
The Penguins lost to Tampa last night but still remain incredibly well-positioned to secure a playoff spot this season. Here’s the relevant standings for them as of now. While there could be other avenues with a Wild Card spot, for now we’ll keep it simple on the most straight-forward path available to Pittsburgh: finishing in […]
Sky Sports: Liverpool must pay £87m to sign electric forward
Leipzig valuation puts Diomande among elite targetsLiverpool and Man Utd have been placed firmly on alert after RB Leipzig set a striking £87.3 million (€100m) valuation on highly-rated winger Yan ...
The key hurdle in Max Verstappen's Super GT ambitions
Verstappen is interested in Super GT, but following in Jenson Button’s footsteps won’t be straightforward
Editorial: Kaufman Astoria Studios foreclosure fight a warning sign for city’s entertainment industry
The foreclosure battle could spell more trouble for New York's entertainment industry going forward.
‘Run it back;’ UD forward to return next season
Dayton forward Jauin Simon posted a graphic social media saying, "Run it back."
Nebraska women’s basketball’s Petra Bozan to enter transfer portal
Nebraska women’s basketball sophomore forward Petra Bozan will enter the portal, On3’s Talia Goodman reported late Thursday night. Bozan, from Split, Croatia, started 19 games this season for the Huskers, averaging 6.6 points per game and 3.4 rebounds per game.
Tobias Harris injury update; Forward exits Pistons game vs Minnesota
Detroit Pistons forward Tobias Harris was ruled out in the second quarter after injuring his knee against the Minnesota Timberwolves.
2026 National Public Health Week
Each April, National Public Health Week shines a spotlight on the systems, people, and partnerships that keep our communities healthy. This year’s theme —Ready. Set. Action! — was chosen by the American Public Health Association (APHA) and calls on each of us to look back at the progress made and look forward to the steps needed for an even healthier future.
SRU hosting three cybersecurity events with expert presenters
A series of collaborative events on the topic of cybersecurity, featuring top forward-thinking industry experts, is happening at Slippery Rock University in April. SRU’s Center…
Barça secure Shane Kluivert's future until 2028
FC Barcelona have officially announced the contract renewal of Shane Kluivert, one of La Masia’s brightest gems.The young Dutch forward has signed a new deal that will keep him at the club for the n...
Paige Bueckers, Sabrina Ionescu 'very excited' for new WNBA CBA
WNBA players like Paige Bueckers and Sabrina Ionescu are "very excited" for the new CBA, allowing the season to move forward.
First Alert Forward: Canadian entrepreneurs bet on St. Louis region for business growth
Three Canadian entrepreneurs have relocated to the St. Louis region, building multimillion-dollar businesses and urging others to consider the area as immigration policy tightens and other cities compete for talent.
Amazon facility in Redding expected to open by summer at Stillwater Business Park
A long-planned vision for industrial growth in Redding is taking a major step forward.
Sixers' Tyrese Maxey gives health update as playoff push moves forward
Philadelphia 76ers star Tyrese Maxey gives an update on his health as the team's playoff push continues.
Roland Go:Mixer Studio review: Portable, professional and plenty of polish
Roland’s latest portable mixer for musicians is a step forward for those looking for a more premium option to bring with them on the go.
Groundbreaking for Deer Creek Behavioral Health Center
Nevada City, Calif. — Nevada County officials, state and local partners, and community members gathered today to celebrate the groundbreaking of the new Deer Creek Behavioral Health Center, a major step forward in expanding access to local mental health care. The facility, located on the Nevada County Government Center campus in Nevada City, is expected […]
PlayStation Plus Free Games For April 2026 Revealed
Here's what PS Plus subscribers can look forward to in April.
The best new science-fiction books of April 2026
A collection of stories set in George R. R. Martin’s Wild Cards universe and a novel from The Expanse author James S. A. Corey are among the science-fiction books we’re looking forward to this month
Car slams into Redlands business, one injured
The victim was hospitalized with non-life-threatening injuries.
Plans move forward for massive sports complex south of Denver
Detroit Axle pushes forward on tariffs lawsuit as business booms
The company braced for \
Oracle laying off thousands of workers to cut costs amid AI push: report
Oracle is reportedly moving forward with layoffs as the software giant looks to restructure its workforce amid an investment in building out AI infrastructure.
MNPL Might and Political Power Meet in Georgia
The annual MNPL Conference recently took place in Savannah, Ga. About 300 IAM Union members, who are dedicated to labor politics and fundraising, heard updates from legislative leaders on the path forward ahead of the midterms. After the conference, IAM delegates participated in the No Kings rally and march in downtown Savannah by calling out
UAB’s Nurse-Midwifery Pathway receives accreditation, a step forward for women’s health in Alabama
UAB’s Nurse-Midwifery Pathway receives accreditation, a step forward for women’s health in Alabama
Yankees news: Ben Rice’s defense looking sharp early
Rice taking steps forward with the glove; Weathers’ new toy; Bednar on past demotion; RIP Ken Clay.
Apple introduces privacy rules for third-party access to notifications
Apple has updated its Developer Program License Agreement with new rules on how third-party accessories must handle forwarded notifications.
Future Forward Business Summit to be held at Beckley Raleigh County Convention Center
BECKLEY, WV (WVNS) — If you want to find out more about the candidates vying for your vote before the primary elections, you are in luck. The Future Forward Business Summit is offering you a chance to...
Jacksonville leaders consider changes to Court Street project after business concerns
A planned construction project on a brick roadway in downtown Jacksonville is moving forward, but city leaders say they are working toward a compromise after co
Coatue Projected $1.995 Trillion Valuation for Anthropic in 2030
In a presentation to prospective investors in January, Coatue offered a rare look at how it justifies Anthropic’s heady valuations. An anonymous source sent me the slides, which give a unique look at how a top investment firm values Anthropic’s business. This is a moment in time when some of America’s most valuable, growing technology companies remain private. In the January presentation, Coatue estimated that Anthropic would lose $14 billion in EBITDA on $18 billion in revenue in 2026, ending the year with $30 billion in annualized run-rate revenue. Most recently, it’s been reported that Anthropic is at $19 billion in ARR, which could suggest Anthropic is already running ahead of Coatue’s expectations. By 2031, Coatue projected that Anthropic would be generating $48 billion in EBITDA profits on $200 billion in revenue, with $224 billion of ARR. That would give Anthropic a 41x forward EBITDA multiple at a projected $1.995 trillion valuation in 2030. Coatue told the investors it was pitching that Anthropic could be worth $2.413 trillion in 2031. In February, Coatue co-led a $30 billion Series G investment in Anthropic that valued it at $380 billion. Coatue declined to comment on this story. I first shared this slide and talked about the presentation on my new podcast, the Cerebral Valley Show, which I host with my CVAI co-hosts Max Child and James Wilsterman. I’ve got a few other slides from the Coatue presentation for Newcomer subscribers.
1% of health insurance tax could fund medical education amid Idaho doctor shortage
Idaho lawmakers are moving forward with a plan to create a dedicated funding stream for medical education as the state faces a doctor shortage.Senate Bill 1420
Moving Sioux Falls Forward: Diamond Mowers
Cities and contractors across the country soon could be maintaining their properties with state-of-the-art new equipment developed and manufactured in Sioux Falls.
50 years of Apple pushing tech forward, for better or worse
Sometimes you have to kill your darlings.
5 underrated Eagles players entering the 2026 season
Here are five underrated Eagles players entering the 2026 offseason, highlighting under-the-radar contributors who could play bigger roles for Philadelphia moving forward.
'Foden needed a big performance... it did not happen'
Phil Foden's World Cup audition ended painfully with the consoling arm of England head coach Thomas Tuchel around his shoulder. The 25-year-old's face was a picture of hurt, primarily from a dreadful challenge by Uruguay defender Ronald Araujo that left him clutching his ankle, but also after a display that left his chances of making the cut for this summer's showpiece in the balance. The Manchester City forward was given the opportunity to strike first in the fight for a fiercely competitive number 10 position as he started ahead of Chelsea's Cole Palmer.
Match Group Is Significantly Undervalued For A Stable, High-Margin Business
Match Group is a mature, high-margin online dating leader trading at a depressed 11x forward P/E, despite stable revenue and profitability. See why MTCH stock is a Buy.
Stars HC Glen Gulutzan details injuries after loss to Flyers
The Stars reached 100 points but lost forwards Michael Bunting and Tyler Myers to injury in a 2-1 loss to the Flyers.
Shaping effective leaders in women’s health: New FIGO Leadership Empowerment Series
FIGO is pleased to launch the Leadership Empowerment Series, a 15-module foundational leadership series designed to equip early career OBGYNs and other women’s health professionals with key skills, confidence and strategic insight needed to drive meaningful, lasting change at local, national and global levels. This series represents a meaningful step forward in FIGO’s commitment to strengthening leadership capacity across our member societies.
Report: Liverpool considering move to sign Serie A forward
Liverpool Transfer Latest: Francisco Conceição Emerges as Salah Contingency OptionLiverpool’s recruitment drive ahead of a crucial summer window continues to gather pace, with fresh developments p...
Sunday Science: The return of the ruby-throated hummingbird
As spring starts to sprout in Southern New England, birdwatcher's have plenty to look forward too. Turning the calendar to April means that the ruby-throated hu
Barcelona send fresh contract offer to Robert Lewandowski
Barcelona have offered forward Robert Lewandowski the chance to remain at the club next season if he so desires. The 37-year-old forward is out of contract next season, and there is no clarity on his ...
Blackhawks’ $22M forward drops bitter truth on Chicago’s season
Chicago Blackhawks forward Tyler Bertuzzi did not hold back after another tough loss, admitting the team is struggling to find answers late in the NHL season. Chicago has now dropped six of its last eight games, falling further out of…
Girls Forward program provides teen girls with safe space to play sports
Elli Lewis, the Girls Forward program manager, and Oana, a participant in the program, join NY1.
UW Huskies AD Pat Chun says state of college sports is ‘not sustainable’
UW athletics has generally performed well during Pat Chun's first two years in Seattle, but he has major concerns about the state of college athletics moving forward.
Texas' Justice Carlton has turned baking passion into full-fledged business
Texas forward Justice Carlton plays basketball and bakes cookies, turning her passion for baking into a full-fledged side hustle.
AI-industry super PACs are mostly winning so far
All but one candidate backed by AI-industry super PACs have moved forward in their respective elections this year.
Poll: What were your favorite announcements at the Xbox Partner Preview 2026?
Microsoft's recent showcase gave us a plethora of Game Pass games to look forward to, so for this week's poll, we want to know: What were your favorite announcements at the Xbox Partner Preview 2026?
Lewis Steele reveals Liverpool’s top target to replace Mohamed Salah
Liverpool Transfer News: Yan Diomande Heavily LinkedIn the latest Media Matters episode from Anfield Index, Dave Davis and Lewis Steele explored Liverpool’s forward planning, with Yan Diomande among...
Sophie Cunningham's Bikini Post Raises a Question for Fans
Fever forward Sophie Cunningham teased fans with a beach social media poll amid WNBA expansion draft uncertainty.
Celtics Projected to Land Rising Alabama Star in Mock Draft
The Celtics are already loaded with forwards
Trey Hendrickson was "looking forward" to playing with Maxx Crosby
Less than 24 hours after the Ravens' trade for Maxx Crosby fell through, the team agreed to terms with Trey Hendrickson.
This Michelin Chef Says Zero-Waste Is Actually Better For Business
At Oyster Oyster, a 30-seat D.C. restaurant with a Michelin star, chef Rubba is building a new business model for restaurants based on zero-waste and plant-forward menus.
The Politics Hour: Fairfax County Board Chair Jeff McKay and 'Crossover Day' in Maryland
Fairfax County Board Chair Jeff McKay on Richmond voting to allow a Tysons casino. Plus, Maryland House Majority Whip Ashanti Martinez on the bills moving forward in th General Assembly.
Business owner faces April 24 move-out as I-26 Connector project advances
After receiving federal approval, the North Carolina Department of Transportation (NCDOT) will move forward with its newest plans for the I-26 Connector project
Constraint and uncertainty ahead for Japanese politics
Japan’s path forward requires reconciling its divided political landscape with urgent reform needs to sustain its domestic stability and regional leadership capacity.
Trump’s signature will soon appear on US dollar bills, a first for a sitting president
US paper currency will soon feature President Donald Trump’s signature going forward, the US Treasury Department announced Thursday, the latest of the president’s efforts to leave his mark across the federal government.
President Trump forms committees as push for college sports reform takes another step forward
These formations come on the heels of a college sports roundtable that took place at the White House earlier this month
Group floats ‘Medicare by Choice’ as a Democratic health care alternative
A coalition of former congressional staffers and federal health leaders is putting forward a health care policy proposal around which it hopes Democrats will coalesce ahead of the 2028 campaign, a …
Small Business Concierge Bill Wins Committee Support » CBIA
Legislation aimed at strengthening support for Connecticut’s small businesses is moving forward at the state Capitol.
Nintendo To Change Pricing For Digital & Physical Switch 2 Exclusives, Starting With Yoshi
Digital to be cheaper than physical going forward
Afeela EVs Really Are Vaporware. Sony, Honda Kill Entertainment-Focused Car
Sony's plans depended on technology from three upcoming Honda models. When Honda cancelled those EVs, Sony did 'not have a viable path forward' on Afeela.
‘NCIS’: Will [Spoiler] Be Back After Shocking Death in 500th Episode?
Plus, how the team will be doing moving forward.
‘NCIS’: Will [Spoiler] Be Back After Shocking Death in 500th Episode?
Plus, how the team will be doing moving forward.
Orlando City signs Antoine Griezmann in landmark MLS move
Orlando City has completed one of the most significant signings in Major League Soccer history, confirming the arrival of Antoine Griezmann from Atlético de Madrid.The French forward will join the cl...
Mohamed Salah: Who is the Premier League's greatest forward?
As Mohamed Salah announces he will leave Liverpool this summer, BBC Sport asks you to rank the best forwards in Premier League history.
Sonova to Sell Sennheiser Consumer Hearing Business
Sonova is selling the Sennheiser branded business to focus on its core hearing instrument and cochlear implant businesses going forward.
The Student Entertainment Board to host their third drag show on March 27
SEB hosts various events throughout the school year, from all night parties and haunted houses to daily movie nights and more. As spring approaches and the clocks move forward, SEB shifts its focus to one of campuses most anticipated and vibrant events of the season: an Up All Night Drag Show. This year, the drag...
Andre Iguodala says winning NBA Finals MVP with Warriors meant ‘nothing' to him
Former Warriors forward Andre Iguodala revealed why winning NBA Finals MVP with Golden State in 2015 wasn't as meaningful to him as one might think.
‘The Price Is Right’ Contestant Loses Big After Listening to Audience
'You're not risking anything by going forward.'
‘The Price Is Right’ Contestant Loses Big After Listening to Audience
'You're not risking anything by going forward.'
Apple releases new updates for old versions of iOS, macOS, watchOS, more
Apple debuted new software updates today for old iOS, macOS, iPadOS, and watchOS versions, including iOS 18.7.7 and more.
Preview: Two injured forwards return for Avalanche in Pittsburgh
The Avs look to get revenge against Pittsburgh tonight.
AI compressed billions of years of evolution into seconds to create 'Lego-like robots' that can recover even when they lose limbs
Modular robots are easily expandable, know when they're upside down or stuck, and can march forward across all kinds of terrain.
Estevao: The rise of Chelsea's teenage Brazilian star
From the dirt pitch to practicing against a rottweiler and Thiago Silva's advice - the foundations of Chelsea forward Estevao's rise.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Segment: Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward
The segment “Financing Action on Extreme Heat and Maternal and Newborn Health: The Way Forward” will examine how innovative and better-aligned financing approaches can respond to these growing risks. Discussions will highlight country experiences in mobilizing domestic resources, opportunities to unlock and scale climate finance, and the role of heat-smart innovations in building resilient health systems. Particular attention will be given to low- and middle-income countries, where exposure and vulnerability remain highest, and where integrated solutions can deliver the greatest impact.
Building a Culture of Health: BJACH Opens Armed Forces Wellness Center at Fort Polk
FORT POLK, La. — Bayne-Jones Army Community Hospital marked a significant step forward in supporting warfighter readiness and community well-being with the grand opening of its new Armed Forces Wellness Center on March 23. The center, located on the first floor inside BJACH, provides Soldiers, Families, civilian employees and beneficiaries with access to personalized health assessments, education and coaching designed to improve overall health and performance.
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs
'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'
Breaking the Cycle review – meet the charismatic Thai politician striving to change his country’s history
Gripping documentary examines the Future Forward Party’s unprecedented 2019 election result, and its leader’s aim to break Thailand’s repeated military coups
BUSINESS MONDAY: Spotlight on Sarah's Cheesecakes & Cafe in Pittsfield
The small family-owned and -operated operation is celebrating its 20th anniversary—and looking forward to many more years to come.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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