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Nintendo details Zelda: Ocarina of Time midnight launch events at Nintendo NY and SF
We’re only two weeks away from the release of The Legend of Zelda: Ocarina of Time’s remake, so Nintendo is getting people ready by detailing what steps
UMHB announces $2 million challenge grant for science lab facility
BELTON, Texas (FOX 44) – The University of Mary Hardin-Baylor (UMHB) has announced that a generous donor who wants to remain anonymous has offered a $2 million challenge grant to support the …
Access Health CT Hosting Nine In-Person Enrollment Fairs Through November
Additional fairs will be announced for December and January, according to Access. All help is free.
Bon Secours Mercy Health to acquire majority stake in Surgery Partners in $5.7B deal
Bon Secours Mercy Health is acquiring a majority share in healthcare services company Surgery Partners in a take-private deal valuing the acquiree at $5.7 billion, the organizations announced Monda | The pending deal values the short-stay surgical platform at $5.7 billion, and is the latest example of large health systems' push to build out their ambulatory networks.
Who's In Charge? The Faces Of Serbia's Student-Backed Political Movement
The Students' List, a political grouping of 250 representatives that just won Serbia’s parliamentary elections, has deliberately avoided having a clear leader. While it remains uncertain who Serbia’s prime minister will be, here are some of the high-profile Serbians representing the movement.
Apple Raises iPad and Mac Trade-In Values
Apple today updated its U.S. trade-in estimates, raising maximum values across the iPad lineup and for most Macs following today's announcement of the new iPad mini. Every iPad category has gained value, although the increases are relatively modest. The iPad mini and standard iPad both rise by $20, while the iPad Air gains $15 and the iPad Pro increases by $10.
Rhode Island FC and Centreville Bank Stadium Name Lou DePaoli as President of Business Operations
Seasoned sports executive brings over 30 years of leadership experience, deep New England roots to Rhode Island FC and Centreville Bank Stadium PAWTUCKET, R.I. (Oct. 26, 2026) – Today, Rhode […]
Business Monday: Longtime Kona sports bar rebrands under new name, Voyagers
The Kona Canoe Club, once a sports bar owned by famed LA Dodgers pitcher Don Drysdale, launched a new name and menu in September: Voyagers.
Celtics Announce Injury Report Ahead of Bulls Game
The Boston Celtics enter Monday night’s matchup against the Chicago Bulls at TD Garden carrying momentum from Friday’s 107-103 win over the defending champion New York Knicks. Jayson Tatum scored 36 points and closed the game with a stretch that silenced a late Knicks run. The response after the opening-night collapse in Detroit was emphatic. […] The post Celtics Announce Injury Report Ahead of Bulls Game appeared first on HEAVY.
“Big Brother” winner Rick Devens’ wife announces breast cancer diagnosis: ‘Send good vibes and prayers’
“Rick won ‘Big Brother’ and then we came home and I got diagnosed with breast cancer.”
Apple unveils new iPad mini with OLED display and faster A20 Pro chip
The new iPad mini features a thinner and lighter design than its predecessor.
NBA announces partnership with prediction markets Kalshi, Polymarket
The deal makes Kalshi and Polymarket the league's preferred prediction markets and will expand the NBA's partnership with DraftKings.
NBA partners with Kalshi and Polymarket amid regulation fight
The NBA announced Monday that it's partnering with prediction markets Kalshi and Polymarket and expanding its DraftKings deal to include a prediction market offering.
LIVE: City launches ‘Jacksonville Food Plan’ to increase access to healthy, affordable food
Jacksonville will launch its first food plan Monday, introducing a framework to improve access to healthy, affordable and nutritious food across the city.
Game on: The 19th is launching a sports desk
In all of our beats, we’ve strived to make our journalism distinct from the work of other newsrooms. We want to bring that spirit to sports coverage.
Kurt Warner apologizes for mixing up Jaylen and Tyler Warren
The Pittsburgh Steelers and New Orleans Saints met on Sunday in the NFL’s first ever game in France. NFL Network was on the call, with Dave Pasch on play-by-play and Jason Kelce and Kurt Warner both providing analysis. But throughout the broadcast, Warner suffered a painful mixup on several occasions, going out of his way…
Knox County Deputies Announce Backing for Sheriff Polky
ROCKLAND — The Knox County Deputy Sheriff’s Association Lodge #700 announced Oct. 26 that it is endorsing incumbent Patrick Polky for Sheriff."Our lodge represents the law enforcement personnel of the
Food Safety Risk Assessment: How Scientists Evaluate Chemical and Microbial Hazards
Food safety risk assessment combines evidence about chemical toxicity and microbial hazards with dietary exposure estimates to evaluate potential health effects. Scientists account for combined exposures, susceptible populations, and uncertainty to guide monitoring, regulation, and preventive measures.
Meta Plans To Raise Up To $95 Billion In Equity To Power AI
Meta stock was lower premarket after the tech giant announced plans to raise $95 billion in equity.
ESSENCE Black Women in Business Luncheon Honors Tamron Hall, Anifa Mvuemba And More
ESSENCE’s 2026 Black Women in Business Luncheon at Villa Lewaro honored Ayiko Broyard, Tamron Hall, Sarah Curtis Henry and Anifa Mvuemba.
SBA disaster loans available to business, private nonprofits impacted by drought
The U.S. Small Business Administration (SBA) recently announced the availability of low-interest federal disaster loans for eligible Wisconsin small businesses and private nonprofit organizations impacted by drought that began on Tuesday, Aug. 18.
🚨 Breaking: Xavi Espart, out for two months for Barcelona
FC Barcelona have announced that Xavi Espart has suffered an injury. The defender had already been forced off against PSG last Tuesday, and then suffered an injury against Real Madrid.The Barça acade...
In brief: Orlando Bloom, Elijah Wood joining 'The Gentlemen'
Netflix is rounding up more gentlemen. Tudum announced Orlando Bloom, Elijah Wood and Ed Speelers are joining stars Theo James and Kaya Scodelario for the third season of The Gentlemen, which is currently filming in the U.K. and Morocco. Also added to the series cast are Dexter Fletcher, Robert Carlyle and Bugzy Malone, who appeared in the 2019 film that inspired the Netflix series. Daniel Ings, who played the drug-addled older brother Lord Frederick “Freddy” Horniman to James’ criminal mastermind Eddie Horiman, told HATC magazine he will not return for the third season. Netflix has not confirmed this …The action-adventure series Fallout has inspired a new reality show. Prime Video has revealed Fallout Shelter: The Experiment, an unscripted competition inspired by the post-apocalyptic drama series and the video game universe. The show “invites everyday participants to test their aptitude for the apocalypse in Vault-Tec's state-of-the-art bomb-proof vault shelters," according to Prime Video. Contestants will “go head to head in a series of high-octane drills, psychological dilemmas and morally challenging behavior trials.” The winner walks away with a $1 million prize. Fallout Shelter: The Experiment will begin streaming in January 2027 … TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); Bravo renewed a slate of its reality shows ahead of Bravo’s Fan Fest on Saturday. New York-based In the City has been greenlit for season 2, while Next Gen NYC is coming back for a third season. For viewers seeking a little Southern charm, The Next Gen universe will be expanding with a spinoff based in Atlanta, and Southern Hospitality is moving forward with a fifth season. Premiere dates have not yet been announced … Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.
Russia to stage World Weightlifting Championships, first major hosting since full-scale Ukraine invasion
The International Weightlifting Federation announced on Sunday that the 2030 world championship event would take place in Moscow.
Bailey, Crosby clash over City Hall, carpetbagging and partisan politics in fierce San Diego City Council race
Nicole Crosby, a Democrat, appears to be the favorite over Richard Bailey, a Republican-turned-independent, in District 2, where registered Democrats far outnumber Republicans.
Student code takes the wheel in Formula 110’s simulated races - College of Arts and Sciences
In a packed lecture hall, first-time programmers raced simulated self-driving cars and got a robotics lesson from the provost. The cars were virtual. The cheering was not.
National Academies Announce 2026 Winners of Eric and Wendy Schmidt Awards for Excellence in Science Communications; $640,000 Awarded
This year’s recipients of the Eric and Wendy Schmidt Awards for Excellence in Science Communications have been selected in recognition of their creative and original work in 2025 to communicate issues and advances in science, engineering, and medicine.
25 faculty recognized for esteemed accolades in research, academia
Rice's winners of highly prestigious and prestigious awards were recognized Oct. 21 to celebrate Rice faculty who have earned these accolades, demarcated by the Organization of the National Research Council and the Association of American Universities.
Rezilient Health Appoints Lisa Ness as Chief Revenue Officer
Rezilient Health announced today that Lisa Ness, MBA, RD, CDE, has joined the company as Chief Revenue Officer. Ness brings more than 30 years of healthcare industry experience, including executive leadership roles at QuadMed, CareATC and Proactive MD. In her new role, she will lead Rezilient's commercial growth strategy as the company expands its relationships with self-funded employers, brokers and health systems nationwide.
Partner1 Renews WBENC Women's Business Enterprise and Women-Owned Small Business Certifications
Recertification caps a year in which founder and CEO Juhi Saha was named to Inc.’s 2026 Female Founders 500 and Partner1 was named an Inc. Power Partner for the second year runningPLEASANTVILLE, N.Y., Oct. 26, 2026 (GLOBE NEWSWIRE) -- Partner1, the advisory firm and software platform behind the partnership strategies of fast-growing B2B software companies, today announced it has renewed its Women’s Business Enterprise (WBE) and Women-Owned Small Business (WOSB) certifications from the Women’s Bu
BCA rebrands political arm to WORKPAC
BCA's political arm will now be known as WORK PAC, BCA CEO Helena Duncan and Chairman Kevin Savoy announced to members gathered in Birmingham. The rebranding is meant to more closely align the business lobby's outward facing mission with the evolving nature of the business community itself, they said.
Manuel Neuer’s Bayern Munich return is still uncertain
FC Bayern is without its captain and a slew of players for the knockout fixture on Wednesday.
Bayern chief to miss Ballon d’Or ceremony
Bayern Munich have announced that Max Eberl will miss Monday evening’s Ballon d’Or ceremony due to illness.The club confirmed that the FC Bayern board member for sport is suffering from a cold and...
Sony backed Soneium plans native token as it expands into entertainment IP
Sony backed Soneium announces plans for a native token alongside new entertainment IP investment products, K-pop royalties and blockchain licensing tools.
Rare burial of elite toddler from pre-Inca culture discovered in Peru
Archaeologists have uncovered the 1,500-year-old burial of an elite toddler from the Moche culture in Peru.
Xbox's Newly-Announced COO Is Leaving Microsoft After 21 Years
"I’m grateful for her years of service and wish her well"
Universal Health Services earnings: what to look for from UHS
Hospital management company Universal Health Services (NYSE:UHS) will be announcing earnings results this Tuesday after market close. Here’s what to expect.
Nintendo Switch 2 gets its first list of Xbox achievements with Minecraft
Minecraft launches on Nintendo Switch 2 on October 27 and includes its own set of Xbox achievements to unlock on Nintendo's console.
Official: Como hand new contract extension to top goalscorer Douvikas
Como have officially announced that the club’s top goalscorer Tasos Douvikas has put pen to paper on a new long-term contract that will see him through until the summer of 2031.Official: Como tie do...
Top salaries at Endeavor Health Clinical Operations
The nine-hospital system announced plans this month to merge with Rush University System for Health.
Top salaries at Endeavor Health Clinical Operations
The nine-hospital system announced plans this month to merge with Rush University System for Health.
Liberty Mutual Re and Celest.Science explore parametric trigger data fallback
Liberty Mutual Reinsurance (LM Re) part of Liberty Mutual Insurance Group, and Celest.Science have announced a collaboration to explore the development of
In his own words: Trump on gas prices and energy costs since launching the war with Iran
Since launching the war with Iran nearly eight months ago, U.S. President Donald Trump has struggled to quell soaring energy costs, undermining Republicans’ attempt to keep control of Congress in the midterm elections next week.
States move to take ultra-processed foods off the school lunch menu
The effort is backed by an uneasy alliance between the right-wing Make America Healthy Again movement and progressives, both motivated by concerns over food safety.
Ex-OpenAI Science Chief Kevin Weil Raises $215M for Drug AI
Former OpenAI science head Kevin Weil launches Warp Sciences with $215 million to use AI and robotics for a critical stage of drug development.
Michigan’s new $82M unemployment system launches Nov. 9 after long development process
The new MiUI system will allow unemployed workers to file claims, certify for benefits, view payments and do other tasks through the platform.
2026 Ballon d’Or: The full list of nominees
The 2026 Ballon d’Or will be announced this evening in a glamorous ceremony in London. The awards recognised the finest footballer on the planet, with several contenders in the conversation for succ...
Wieden+Kennedy launches entertainment division to make movies and shows—with and without brands
W+K Entertainment will develop original projects, starting with a Bad Bunny film, and help clients break into Hollywood.
Smithsonian scientists launch "Lumina" simulation to model early universe
Researchers introduce "Lumina," a massive cosmological radiation-hydrodynamics simulation designed to model the universe's first two billion years
Hollywood's uncanny evolution of evil billionaire tech bros
If you really want to understand the extent to which everyone thinks Silicon Valley is so uncanny these days, watch "Cupertino."
'Wheel of Fortune' Jim Thornton: FBI Never Contacted Witness in Pedo Chatroom Scandal
The woman who says she saw disgraced 'Wheel of Fortune' announcer Jim Thornton in a pedophile chatroom on a plane has NEVER been contacted by the federal agency that would investigate such matters -- the Federal Bureau of Investigation -- TMZ has learned.
Business News: Audemars Piguet Unveils 'The Watch Keepers' - A Digital Platform Offering Certified Pre-Owned Watches
The Le Brassus watchmaker will facilitate sales and auctions of brand-certified timepieces on a digital platform launching in Switzerland and Europe, with plans for expansion to other markets, including the U.S.
12 AI models were asked what they really think about humans — and almost all agreed on one uncomfortable truth
29 of 35 responses shared the same theme
How Functional Foods Deliver Bioactive Compounds and Support Gut Health
Functional foods use delivery systems such as encapsulation, lipid carriers, and hydrogels to protect bioactive ingredients and control their release during digestion. These technologies may improve nutrient availability, but human studies are needed to establish their health benefits and long-term safety.
Cris Collinsworth Turns Heads With Unusual Praise of Patrick Mahomes
Announcer Cris Collinsworth was criticized after he praised Chiefs quarterback Patrick Mahomes for recovering a fumble. The post Cris Collinsworth Turns Heads With Unusual Praise of Patrick Mahomes appeared first on HEAVY.
Marco Rubio’s Greek Panegyric / Celebration: Political Theory and Praxis
Prologue Translating the ideals of Greek history, politics, democracy, theater, athletics, the Delphi peace vision, philosophy, science, technology,
Chiefs Announce Historic Travis Kelce News During Seahawks Game
Kansas City Chiefs tight end Travis Kelce can’t stop making NFL history.With his third reception in the fourth quarter against the Seattle Seahawks on Sunday night, Kelce has passed Hall of Famer Tony Gonzalez for the most receiving yards by a tight end ever, including the postseason, with 13,342.Kansas City Chiefs’ Travis Kelce is Most […] The post Chiefs Announce Historic Travis Kelce News During Seahawks Game appeared first on HEAVY.
‘End the blame game’ — Healthcare finance leaders launch a new affordability pledge
Finger-pointing is not stopping the erosion of financial sustainability of U.S. healthcare, according to the Healthcare Financial Management Association.
American Hospital Dubai and HEI Global Health Announce Strategic Partnership to Collaboratively Build an Advanced AI-Powered Revenue Cycle Innovation
DUBAI, United Arab Emirates--(BUSINESS WIRE)--Oct 26, 2026--
How to Manage Symptoms of Heart Failure
(Feature Impact) Americans are facing a growing health challenge, with 1 in 4 adults at risk of heart failure, according to the Heart Failure Society of America. Additionally, approximately 6.7 million U.S. adults who are 20 years old or older are currently living with heart failure, and that number is projected to reach 8.7 million by 2030. googletag.cmd.push(function() { googletag.display('JGFI_Article_300x250'); }); Managing heart failure is a significant expense to the U.S. healthcare system, costing the nation approximately $40 billion in 2020 and expected to increase to approximately $142 billion a year by 2050.If you (or a loved one) are living with the condition, consider these tips to help manage it.Adhere to the Treatment and Follow-Up PlanOngoing outpatient care is important when managing heart failure. Understand the treatment plan provided by your healthcare team, make diet and lifestyle changes, take medications as directed and keep recommended follow-up appointments.Pay attention to changes in symptoms and communicate with your healthcare provider if treatment does not seem to be working as expected. If their conditions are left unmanaged, patients can experience a range of heart-failure-related symptoms such as shortness of breath, fatigue, buildup of fluid and more.Understand Challenges with Diuretic TreatmentDiuretics help the body remove excess fluid and are commonly used to treat swelling, or edema, associated with heart failure. Your provider may try different diuretics, sometimes referred to as “water pills,” to manage your heart failure symptoms. However, intravenous (IV) diuretic therapy may be required for some patients if symptoms continue.Ask About Treatment Options Before IV Care Is NeededFor some adults, a healthcare provider may consider recommending an at-home, non-oral diuretic option prior to escalating to IV therapy.For example, ENBUMYST™ (bumetanide nasal spray) is a prescription diuretic used in adults to treat edema associated with congestive heart failure. It’s administered as a nasal spray for short-term use to manage excess fluid with the goal of transitioning to oral diuretic therapy when appropriate.Talk with your healthcare provider to learn more and visit enbumyst.com. Read the full Prescribing Information and Patient Information.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('JGFI_Article2_300x250'); }); Important Safety InformationWhat is ENBUMYST?ENBUMYST is a prescription medicine used in adults to treat swelling caused by excess fluid in the body (edema) from congestive heart failure, liver disease, and kidney disease.What is the most important information I should know about ENBUMYST?ENBUMYST is a diuretic that helps your body remove fluid. Losing too much fluid can cause dehydration, low blood volume, and increase the risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The risk of these abnormalities is higher in elderly people, those using higher doses, or those who do not get enough electrolytes by mouth.You should not use ENBUMYST if you have severe electrolyte loss. Tell your healthcare provider if you experience unusual thirst; dizziness or lightheadedness; weakness or tiredness; fast heart rate; dry mouth or tongue; sudden pain; redness or swelling in your joints; pain, swelling, redness, or warmth in your leg; shortness of breath or fast breathing; high blood sugar; dark urine; pale, tight, cool or clammy skin; muscle cramps; confusion.Do not use ENBUMYST if you have low or no urine production or are allergic to bumetanide or to any of the ingredients in ENBUMYST.Before using ENBUMYST, tell your healthcare provider if you have low electrolytes, are on a low-salt diet, have diarrhea, diabetes, nasal problems such as a runny or stuffy nose or polyps, a history of nasal injury or surgery, are or plan to become pregnant, are or plan to breastfeed.Tell your healthcare provider about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.ENBUMYST may cause serious side effects, such as worsening kidney function and ringing in the ears or hearing loss.The most common side effects of ENBUMYST include dehydration, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning with certain liver problems.These are not all the possible side effects of ENBUMYST. Talk to your healthcare provider for more information.Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.US-ENBU-2600110 googletag.cmd.push(function() { googletag.display('JGFI_Article3_300x250'); });
Eric Bauza, the voice of Bugs Bunny and many other Looney Tunes characters, dies suddenly, family says
Voice actor Eric Bauza, who succeeded Mel Blanc in voicing lovable Looney Tunes characters like Bugs Bunny, Daffy Duck and Porky Pig, had died, his family announced Sunday night. The family issued …
Raptors’ Kawhi Leonard to undergo testing after concerning injury update
Kawhi Leonard was missing in action on Sunday, as the Toronto Raptors lost to the Minnesota Timberwolves , 117-94, at Target Center. The Raptors fell to 2-1, while the Timberwolves improved to 3-0. Leonard was added to the injury report just an hour before tip-off. Toronto announced that the veteran forward was dealing with swelling in his left […] The post Raptors’ Kawhi Leonard to undergo testing after concerning injury update appeared first on ClutchPoints.
US has plans for major Iran strikes if Trump chooses
US forces in the Middle East are prepared to launch new, potentially major, military operations against Iran “within 96 hours of receiving” an order from President Donald Trump, according to two US officials.
Asking Eric: Family bans ‘quirky’ friend from holidays
How does the letter writer tell a friend she's not welcome at family functions anymore?
Why Fulton County is at the center of Georgia politics
Over the past decade, Georgia has become a closely watched swing state thanks to Fulton County's emergence as a political powerhouse—and the focal point of Donald Trump’s efforts to challenge his 2020 election loss—but its influence wasn’t always so pronounced.
The best apps for tracking your reading and discovering new books
There are many apps that are designed to help you track your reading and discover new books, so we compiled a list of some of the best ones.
Pokemon Pokopia datamine seemingly leaks full DLC 2 Pokemon lineup
Pokemon Pokopia datamines have revealed a whole bunch of new Pokemon that will most likely be added in the second wave of DLC.
First round of 2026 high school football playoff matchups announced
Several area schools will play in the first round of the 2026 high school football playoffs this week.
Health network adding helicopter in rapid Pennsylvania expansion
WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System…
Health network adding helicopter in rapid Pennsylvania expansion
WESTMORELAND COUNTY, Pa. (WHTM) — Not long after they acquired five Pennsylvania hospitals, a health system will soon launch an air medical helicopter in the Keystone State. WVU Health System recently...
Dunwoody to discuss adding two entertainment districts
The Dunwoody City Council will discuss adding two new entertainment districts – Georgetown and Jett Ferry – at its meeting on Monday, Oct. 26.
Sunday Sports: Section 3 football matchups announced and more
Here’s a recap of your North Country sports this Sunday.
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift
It was a seismic political shift in the Balkan country where Vucic, who had been endorsed by Russian President Vladimir Putin and who denounced the student movement as a foreign-led attempt to unseat him, led with virtually absolute power for 14 years.
Missile makers see multi-year deals as politics-proof
Executives at the military’s biggest suppliers say the Pentagon’s new multi-year munitions deals are the surest way to navigate an uncertain funding climate.
Aleksandar Vucic concedes defeat in Serbia's parliamentary election, marking political shift
Aleksandar Vucic, who denounced the oppositional student movement as a foreign-led attempt to unseat him, led with virtually absolute power for 14 years.
Cooper Health launches new mobile addiction and recovery program
The program will focus on high-need areas in the city and respond elsewhere when called, helping to connect people to addiction support services. | KYW Newsradio
Health West Chubbuck expands hours, adds X-ray services and two new providers
CHUBBUCK — Health West has announced that it has expanded the services offered at Health West Chubbuck and that it has added two new providers to its staff as well
Instant analysis after Bengals wake up, trounce Ravens
Quick notes and takeaways after the Bengals beat the Ravens in Week 7.
Merit Health announces Trunk or Treat for Thursday
merit: Join the fun at Merit Health River Region's annual Trunk or Treat on October 29. Dress up and enjoy festive activities!
Barcelona host Real Madrid in anticipated Clásico clash
2026-10-25T20:12:58ZThere have been a few crunching tackles on both sides in the last few minutes and now the benches have taken exception as there is a little coming together in the center of the par...
Nets' Second-Year G Dëmin Bounces Back Against Cavaliers
The Brooklyn Nets got a much-better performance from second-year BYU product Egor Dëmin against the Cleveland Cavaliers. With Mikel Brown Jr. on a minutes restriction, Dëmin needs to play a big role.
Cardinals Week 7 inactives
Cardinals announce seven inactives ahead of Week 7 game
Business People: Evereve names industry vet Sarah Clary to advise on creative
RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…
Warriors honor Bay Area sports reporter Michael Wagaman
After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…
Bloomington business continues to blossom
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Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
Connections: Law firms hire attorneys for NWA offices
Two Little Rock-based law firms have hired attorneys for their Northwest Arkansas offices, and the Single Parent Scholarship Fund of Northwest Arkansas recently announced new board members. NEW HIRES Banking...
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
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Investment driving growth at NWS Crane
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Health board still paying for research with 'unclear' patient benefit
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Business Briefcase: Open-air downtown farm market continues
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