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Pine Island data center supporters make case to Rochester area business leaders
The Rochester Area Chamber of Commerce hosted an information session Wednesday for several dozen business leaders from across the region.
AMC Entertainment (AMC) Among Our Best Penny Stocks According to Billionaires
AMC Entertainment Holdings, Inc. (NYSE:AMC) is one of the Best Penny Stocks to Invest In According to Billionaires. Recently, on June 25, AMC Entertainment Holdings, Inc. (NYSE:AMC) announced the closing of a registered direct stock offering by selling 95,250,000 shares at $2.00 each. The company raised approximately $200 million in gross proceeds. Management noted that […]
Vikings Get a Little Shade from ESPN
Among the Minnesota Vikings’ fan base, hopes are high for 2026, mainly because the club acquired Kyler Murray in March […]
Harvard Kennedy School names Betsy Fischer Martin as director of the Institute of Politics
Harvard Kennedy School today named Betsy Fischer Martin as the next director of the Institute of Politics (IOP). She will begin her tenure in mid-August, succeeding interim co-directors Beth Myers and Ned Price, who have led the IOP since December 2025.
United must face lawsuit over 'window seats' that don't have windows, judge rules
A federal judge ruled passengers plausibly alleged United Airlines breached its agreement by selling certain window seats without an actual window, allowing the proposed class action to proceed.
Fathom Entertainment New CEO Is Jason Brenek
He succeeds Ray Nutt, who announced his retirement earlier this year.
Leading Food Companies to Share the Science and Technology Behind their Latest Innovations at IFT FIRST Annual Event and Expo
CHICAGO, July 08, 2026--The Institute of Food Technologists (IFT), a nonprofit scientific organization committed to advancing the science of food and its application across the global food system, is proud to share a sneak peek at a few of the supplier scientific sessions and demonstrations that will take place at IFT FIRST Annual Event and Expo, the leading food science and innovation expo being held July 12-15, 2026, at McCormick Place in Chicago.
Gov. Beshear requests health update on Sen. Mitch McConnell
Gov. Andy Beshear sent a letter Wednesday, July 8, to the Sen. Mitch McConnell’s office requesting an update on the senator’s health.
After Aidan Hutchinson, who will lead the Lions in sacks?
Besides Aidan Hutchinson, who will bring the “juice” in the Lions pass rush in 2026?
Hungary moves to overhaul university models banned from Horizon Europe
Hungary’s new government is aiming to overhaul the governance model of the institutions and universities that lost access to Horizon Europe and Erasmus+ funds “in a short timeframe,” according to Péter Horváth, the new state secretary for science policy and innovation. “As of today, the two non-university foundation-controlled institutions under my remit have been transformed,” he told Science|Business. “We hope the universities will follow and that this will be enough to satisfy the EU’s demands.”Under the previous government, led by Viktor Orbán and his Fidesz party, many academic and scientific institutions were restructured and made into special public trust foundations, with members strongly linked to the government given lifelong mandates and significant decision-making powers with little oversight. The European Commission deemed that this undermined academic freedom and transparency in the country, leading to a ban on 34 institutions in 2022, including 21 universities, which saw academics in Hungary lose access to Horizon Europe grants. The new Hungarian government, elected in May and led by Péter Magyar and his Tisza Party, has promised to dismantle this governance model and restore the institutions to EU programmes. As a result, the European Commission has promised to return access to the Erasmus+ education mobility programme, but so far no concrete agreement has been made on the Horizon Europe programme for research and innovation. Hungary has already made legislative changes in June to allow the institutions to be reformed and set a timeline for the implementation.The non-university foundations, which are mainly cultural centres such as the Foundation for Hungarian Culture or the Makovecz Campus Foundation, will all be dissolved by August 31 this year, a date tied to EU-set milestones that Hungary must meet to unlock frozen funds, with control transferred to relevant ministries. Meanwhile, the universities will have until 31 August 2027. For each university foundation, the government will set the dissolution date and the body to take over operations. There is no final decision on a permanent new model for the universities, according to Hungarian MEP Eszter Lakos, who is shadow rapporteur for the Horizon Europe specific programme, a separate piece of legislation detailing implementation rules for the EU’s next research programme, due to start in 2028. “The aim of the transition year is to settle this with [the universities], not to impose a model, and not to put them under state control,” she told Science|Business. “The goal is to give academic independence back to universities.”There are three models that are most likely to be implemented. One would be a return to a traditional, state-run model. Another could be a newer, more self-standing public institution. A third option would be a reformed version of the foundation models that meet EU standards. According to Lakos, the dismantling of the system put in place by the Orbán government is well underway and if all goes according to plan, Hungary could regain access to EU research money by the start of the next academic year in 2027. “I believe that the Hungarian government is doing the necessary changes so the universities could return as beneficiaries to Horizon from the next school year,” she said. In the meantime, “the universities, institutes and cultural assets carry on under proper public stewardship rather than a handful of unaccountable trustees,” said Lakos. The laws passed in June impose new safeguards: board terms are capped at four years and renewable only once, appointments are made through open competitions and sitting politicians cannot join joining these boards.It remains unclear whether a domestic science funding programme set up as a back-up scheme by the former government following the EU funding ban, called HU-rizon, could be continued. “This programme should never have had to have been established in the first place, but it has proven to be quite popular,” he said. “I am considering continuing this programme with a refined focus on helping international collaborations.”Re-organising the research network One of the first priorities for Horváth and his cabinet is to resolve questions over the future of the Hungarian Research Network, Hun-Ren. The network of academic institutes was taken away from the Hungarian Academy of Sciences in 2019 and turned into a quasi-private organisation, with similarities in its governance to the public trust foundations.Horváth and his team have consulted over 5,000 representatives from the network and the conclusion is broad unhappiness with the directors of all the institutes involved. “We have presented the results to the president and the chief executive of the network and this is currently being discussed,” Horváth said. The plan is to re-integrate the network back into the Academy of Sciences but in an improved way, “learning from mistakes of the past,” he added. The government also wants to reintegrate four humanities and social science research centres into the network that the previous government had transferred to Eötvös Loránd University. The transfer brought sharp criticism from the academic community, with a group of Hungarian research heads, including European Research Council grant recipients, sending an open letter to Orbán warning that the transfer would “cause historically significant harm to the entirety of Hungarian scientific life.” The transfer was “one of the biggest shames in Hungarian research in the past 20 years,” Horváth said. “We want to immediately re-integrate them back into the research network and to regain the trust of these institutions, because the way they were treated was really unfair.”Another pressing issue is the Élvonal Excellence Research and Talent Development Foundation, led by Nobel laureate Ferenc Krausz. The foundation signed a financing agreement with the former government earlier this year for a budget of over €730 million over the next five years. The goal is to create a world-class centre to attract top talent from abroad and to develop local researchers. But there was little transparency about this foundation, and news of its huge budget, which is nearly as much as Hungary’s entire research budget, caused a stir in the media following the recent elections. Another issue is that, as with the foundation boards of the institutes banned from Horizon Europe, there was little-to-no oversight of decisions led by Krausz. “It was an excellent idea but an unacceptable execution,” Horváth said of the foundation. “The fact that this is out of the Hungarian funding scheme, mostly concentrating on one person who decides on the budget is unacceptable for us.”The government plans to merge the centre with the National Research, Development and Innovation Office, the country’s R&D funding agency, with a reduced budget. Horváth is hopeful that Krausz will still be involved. The new government’s R&D goalsA phrase that crops up regularly during the discussion with Horváth is “democratic process.” The new state secretary is determined to involve Hungary’s research community in shaping future policies. This marks a departure from the previous government’s approach, and several people in Hungary’s research community have commented on the openness of the new government. In terms of concrete goals, Horváth and his team already have plans. He wants to create a new science fund in Hungary, based on the best practices of other European countries. The fund would not be tied to annual government budgets and would provide long-term, stable financing. “If we were to succeed in creating this fund, then I think it would be one of the biggest achievements for me in this period of government,” Horváth said. On the innovation side, he is looking into how best to bring in the private sector. “We want to make sure that we are working with the private sector to support innovation,” Horváth said. One of his big aims is to introduce entrepreneurship teaching into high schools. Hungary already has a reputable national academy offering research and innovation training in the field of natural sciences, and Horváth wants to expand this to all disciplines and across the whole country. “One of the main ways to elevate our innovative businesses is to teach our children to be innovative,” he said. “This will probably need ten years to pay off, but this is what we should do. Our aim is to make Hungary strong in our region, and this is what is needed.” Related articlesHungary’s Horizon Europe performance in numbersCommission unlocks Erasmus+ cash for Hungary, Horizon could be next‘Academic Huxit.’ Hungarian researchers speak out on impact of EU ban A more difficult task will be funding. The new government is aiming to increase research spending to 2% of the GDP by 2030, and then increase it to 3% in line with EU objectives. Currently, spending sits around 1.3%. But according to Horváth, the current budget, inherited from the previous government, is “heavily in the negative,” so any plans to increase research spending will have to start next year. Achieving 2% by 2030 already needs a big push, almost doubling the research budget. “This is something we’d definitely like to reach, and something I can see us achieving,” he said. “From the 2030s, I’d like to see an innovative generation growing up that can help us reach the 3% target.” Positivity in the new governmentDespite the many challenges facing Horváth and his team, the mood is positive. “It feels a bit like a start-up right now. Everyone is working 24/7, day and night, trying to do as much as they can. There is a lot of energy,” he said. It is a big change for the state secretary who, like many in his cabinet, is coming from a background in research or business, and not in politics. “Six weeks ago, I was sitting with my microscope and my research PhDs, so it’s been a big change for me,” said the computer scientist, who was previously the director of the Institute of Biochemistry at the Hun-Ren Biological Research Centre in Hungary and worked at the Institute for AI for Health at Helmholtz Munich. But he is relishing the task to transform the country’s R&D landscape. “We feel enormous support from the Hungarian people, but also from Europe,” he said. “We’ve received a lot of letters of support from around Europe. There is big trust there, and huge responsibility on our side. We want to get everything back on track, and there’s a lot to do.”
House candidates make their pitch for how they’d support Central KY business community
Dr. Ralph Alvarado and Zach Dembo won their respective primaries to succeed Republican Rep. Andy Barr in the U.S. House of Representatives.
Gillette Chamber of Commerce reflects on 70 years of business growth, community support
GILLETTE, Wyo. — The Gillette Chamber of Commerce is celebrating 70 years of helping local businesses connect, grow and succeed in the community. The Chamber was started in 1956 by a group of local business owners. Today, the organization works as a link between businesses and local, county and state leaders. CEO Gail Loafing said […]
First look at Harry Jowsey’s new Netflix reality dating show “Let’s Marry Harry” (exclusive)
Harry Jowsey of “Too Hot to Handle” and “Perfect Match” fame is looking for true love.
Tracee Ellis Ross is making her Broadway debut and completing a bucket-list item
Tracee Ellis Ross is making her Broadway debut in “Every Brilliant Thing.”.
Exclusive: Integral Ad Science hires Lidiane Jones as CEO
The former CEO of Bumble and Slack will succeed Lisa Utzschneider.
Science review panel finds CIRES delivers exceptional value to NOAA and the nation
Reviewers concluded that CIRES consistently exceeds its goals and significantly enhances NOAA's scientific and operational capabilities.
Intelligent Computing appoints Philip S. Yu and Osmar R. Zaïane as new editors-in-chief
Intelligent Computing, a Science Partner Journal co-founded by Zhejiang Lab and the American Association for the Advancement of Science(AAAS), has appointed Philip S. Yu and Osmar R. Zaïane as its new Editors-in-Chief. Philip S. Yu and Osmar R. Zaïane succeed the journal's founding Editors-in-Chief at a pivotal stage of development, as Intelligent Computing continues its rapid growth as an international open-access journal dedicated to advancing the convergence of intelligence and computing.
Research shows how behavioral science silently protects American consumers and patients
A new Proceedings of the National Academy of Sciences (PNAS) special feature highlights the critical role of behavioral and decision sciences in U.S. governance. The publications demonstrate how psychological ...
Crowd work comedian Jeff Arcuri is ready to meet you
Stand-up comic Jeff Arcuri has become the guy from your Instagram reels you can’t quite place, now turning viral crowd work clips into his first Netflix special, “Nice to Meet You.”
Lawmakers end multi-million-dollar hospital tax “loophole”
By Michelle Crouch Co-published with The Charlotte Ledger A little-noticed provision in the state budget that was approved last week aims to shut down a tax strategy used by at least one hospital system to exceed the state’s sales tax refund cap. The change would require nonprofit and public hospital systems to file a single […]
Golden Knights sign last remaining RFA with NHL opportunity
While any business outside the organization is still up in the air, the Vegas Golden Knights have succeeded in getting all of their internal affairs in order.
"Don't Kill the Disc": Petition Against Sony PS5 and PS6 Digital Media Plans Reaches 120,000 Signatures
"We are not against digital. We are against digital being the only option."
Impeachment trial for Philippine Vice President Sara Duterte begins
The frontrunner to succeed President Ferdinand Marcos Jr will be barred from public office if convicted.
Continental Agrees to Sell ContiTech Business to Lone Star Funds
Continental expects the deal to generate cash proceeds of approximately 3.1 billion euros, some of which will be used to cut debt, with around 2.5 billion euros distributed to shareholders.
DEVELOPING: Roanoke PD says it’s investigating Roanoke dog daycare business
In a social media post on Sunday, July 5, 2026, the agency announced an active investigation was being conducted.
Analyst Predicts Oklahoma's Best and Worst-Case Record for 2026
One analyst sees Oklahoma's ceiling at 10 wins, but warns offensive issues could lead to 6-6.
10 Most Important Bears of 2026: #8 Grady Jarrett
Next up in @wiltfongjr’s 10 Most Important Bears series is defensive tackle Grady Jarrett. Can the 33-year-old turn back the clock?
Best and worst long-haul airlines, from someone who only flies economy
I've tested a dozen different airlines to find the best for long-haul travel. Etihad Airways exceeded expectations, while China Eastern wasn't for me.
JD Vance says British politics 'broken' ahead of expected UK Prime Minister transition
Lawmaker Andy Burnham is widely expected to succeed Starmer after emerging as the sole candidate to replace the outgoing leader.
Referee appointment for Spain vs Portugal confirmed
The referee chosen to take charge of the upcoming showdown between Spain and Portugal has on Saturday evening been confirmed.The official primed to oversee proceedings at Dallas Stadium? Anthony Taylo...
10 Legionnaires' disease cases on NYC's Upper East Side under investigation, health officials say
Mesa Business Builder Offers Support for Local Entrepreneurs
Mesa Business Builder provides free consulting to help local businesses grow and succeed, reflecting the city's commitment to entrepreneurship. Mesa Business Builder Offers Support for Local Entrepreneurs
Healthy Living with Northern Light Health: summer grilling
Summer grilling season is here, and while cookouts are often associated with burgers, hot dogs, and heavy side dishes, the grill can also be a great tool for creating healthy, flavorful meals.
Brunch Box celebrates four years in business with new homemade donut
A local food truck known for serving up brunch across the Tri-Cities is celebrating a milestone with a sweet new addition.Brunch Box is celebrating four years i
Hiltzik: What does the GOP have against children?
The conservative war on child health starts with the anti-vaccine campaign and proceeds to cutbacks in nutrition assistance and narrowed access to healthcare.
Valve releases Steam Machine e-ink faceplate CAD files and firmware
Build your own "inkterface".
Gov. Jeff Landry says he will ask State Police to investigate after Liz Murrill’s indictment
Gov. Jeff Landry said he would have State Police investigate the proceedings and those who led them.
Jensen Huang's leather jacket could fetch $60,000 at auction
Nvidia CEO Jensen Huang's black Tom Ford leather jacket is up for auction, with proceeds benefiting charity, Sotheby's said.
Portugal vs. Croatia live score, result, highlights from 2026 World Cup knockout game
The Sporting News is tracking live scoring updates and highlights for Mexico vs. Ecuador in the 2026 FIFA World Cup.
Cowboys 2026 roster rundown: WR CeeDee Lamb
What are your expectations for CeeDee in 2026?
Rivian boosts delivery outlook as EV sales top estimates
The company now expects to deliver between 65,000 and 70,000 vehicles this year, exceeding the roughly 63,000 deliveries expected by Wall Street analysts.
PACE Provider myPlace Health Achieves High-Acuity Care Reductions
The SCAN Group affiliate myPlace Health has acheived significant reductions in hospitalizations as its program exceeds 300 participants. The company
Is Titans' Cam Ward poised to take a step forward in 2026?
CBS Sports ranks Tennessee Titans quarterback Cam Ward as a promising prospect despite his uneven rookie season performance.
Will Ferrell says dad gave him the 'best showbiz advice ever'
Even though it wasn't a "rah-rah speech," Will Ferrell said his father's words "took the pressure off succeeding."
A GOP lawmaker who owns a fireworks business urged followers to defy Utah Gov. Cox’s pyro restrictions
As Utah Gov. Spencer Cox orders statewide firework restrictions to prevent new wildfires, a GOP lawmaker — who co-owns a firework business — encouraged Utahns to go ahead with pyrotechnic celebrations anyway.
New Illinois Republican Party chair hopes for ‘JB fatigue’ in tough midterm
In an interview with Capitol News Illinois, Bob Grogan, who was elected party chair in May, said he knows what bridges he needs to build for the party to succeed in the 2026 midterms.
ASU scientists unveil new methods to extract reliable truth from imperfect data
Scientists at Arizona State University are advancing how they interpret complex, imperfect data — challenging long-standing assumptions in fields ranging from imaging to cellular biology. In two papers published in Nature Communications and Proceedings of the National Academy of Sciences, the team introduces fundamentally new approaches to solving “inverse problems,” where researchers work backward from noisy observations to uncover the underlying reality.
Debunking bad advice with CBS News business analyst Jill Schlesinger
2026 NFL WR dynamic duo rankings: Cowboys' Cee Dee Lamb-George Pickens tandem among elite
Which NFL team has the best pair of wide receivers?
AMC Entertainment (AMC) Is Down 8.7% After Equity Raise To Retire 2027 Notes And Fund Upgrades
In late June 2026, AMC Entertainment Holdings, Inc. completed a registered direct equity offering of about US$200.03 million and moved to fully redeem US$125.47 million of its 6.125% Senior Subordinated Notes due 2027 at par plus accrued interest. The company plans to use the remaining proceeds to bolster cash reserves and fund growth-oriented upgrades across its theatres as early as this autumn. Next, we’ll explore how using fresh equity capital to retire higher-cost debt and invest in...
‘Tip of the iceberg’: nearly 500,000 New Yorkers lose health insurance due to Trump cuts
First of major coverage losses expected as a result of the ‘One Big Beautiful’ bill signed into law one year ago
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
3 Reasons Why I'm Loading Up on Penn Entertainment in the Second Half of 2026
Penn Entertainment stock is soaring and it has the potential to build on those gains in the second half of 2026.
New England Patriots 2026 NFL Season Preview
It’s no secret that the New England Patriots exceeded expectations last season. While many of their top players will be returning, they also lost some key talent during free agency as well as adding some additional depth. The Patriots dealt with a lot of talk about strength of schedule last year, and that will once again be a part of the conversation, but this time it’s at the opposite end of the difficulty spectrum.
Colorado Supreme Court: Redistricting plans for 2028 election cannot proceed under state constitution
The Colorado Supreme Court blocked all attempts at redrawing congressional district boundaries for the 2028 election from reaching the ballot on Monday, concluding each of the proposed ballot measures violated the constitutional single-subject requirement. The court considered five distinct, but related, ballot measures. Three proposals would have redrawn U.S. House of Representatives districts to give […]
Essentia Health-Cloquet Clinic welcomes Jaycee Hewitt to practice family medicine
Jaycee Hewitt, an advanced practice registered nurse and certified nurse practitioner in family medicine, is thrilled to join the Essentia Health-Cloquet Clinic.
Visit Baton Rouge’s new headquarters project hits a snag
Visit Baton Rouge's plans to relocate its headquarters into a historic downtown building on Lafayette Street have been delayed after construction bids exceeded the organization's previous estimates by… Already an INSIDER? Sign in. Already an INSIDER? Sign in
Comcast Announces Plan To Split Tech And Media Businesses With NBCUniversal Spinoff
The company said it expects the split to be completed within a year, with Comcast’s shareholders owning shares in both companies.
Evans Has Reportedly Been 'Unguardable' at 49ers Practice
The future Hall of Famer is stunning teammates in San Francisco, dominating red zone drills and exceeding high expectations as he anchors a loaded arsenal for Brock Purdy.
Meaningful Outcomes Determine the Winners of the Health AI Race
Global investment in healthcare AI exceeded $18 billion in 2025, yet health systems still lack a shared understanding of the outcomes that investment should deliver. This paper argues that success in the health AI race will be determined not by technological sophistication but by which systems first identify and pursue the outcomes that matter most to patients, professionals and health systems. Without a shared language for defining and measuring what healthcare AI should deliver, systems risk optimizing for what is easiest to count rather than what matters most. This paper provides a framework for ensuring AI investment translates into real value for healthcare systems and the populations they serve.
Q&A: Why humanitarian aid is crucial to stopping the Ebola outbreak
Health officials say the Ebola response cannot succeed without addressing the humanitarian crisis.
Winner and Loser of the Week in Florida politics
FDACS moves fast on the mealybug threat, while Ye's Tampa concerts proceed despite pushback.
Tariffs continue to add uncertainty to business climate: Top Workplaces 2026
Companies like Gardiner HVAC in Solon are navigating fluctuating prices and supply chain disruptions as tariff policy remains volatile more than a year after implementation.
New business brings hat bar experience to Mineral County
Haley Nelson started her business in November 2023 in Lake Havasu City, Arizona. Since moving to Montana, she has remained busy fulfilling online custom orders and shipping hats to customers across the country.
Two years after their last debate, Biden jabs at Trump: ‘What a loser’
As he rallied Maryland Democrats at a state party fundraiser Saturday night, former President Joe Biden decried the actions of the man who succeeded him in the White House, painting him as vain and corrupt.
Report: Rockets have been linked to Lakers' Marcus Smart
The Rockets reportedly have interest in signing Marcus Smart away from the Lakers if he declines his player option for next season.
Star Wars Eclipse "literally cannot be finished" without more staff, insist striking Quantic Dream developers
Striking staff at Quantic Dream have warned that if the studio proceeds with layoffs, its upcoming Star Wars Eclipse game "literally cannot be finished".
Phillies vs Mets Prediction, Picks & Odds for Today's MLB Game
The Phillies have been hot, and our expert MLB predictions expect their winning ways to continue against the lowly Mets.
Gen Z traders launched a trading platform to fight bad 'finfluencer' advice
Ivan Patriki and Carson Hein founded QuantMap to counter the bad info they say is all over social media and to give traders better tools to succeed.
Yankees news: Grisham on the comeback trail
CF working back from injury; Goldy’s resurgence; the Boston boys in pinstripes
Meet Troy Rohrbaugh and Doug Petno, who are vying for Jamie Dimon's job
Doug Petno and Troy Rohrbaugh are the frontrunners to succeed Jamie Dimon. Here's a guide to the men in line for one of Wall Street's top jobs.
Who is the 49ers best player in 2026?
The 49ers have several players that made a preseason Top 100 list.
Securitize and Cantor Equity Partners II Business Combination Expected to Raise Approximately $400 million in Gross Proceeds and Announce Expected Closing of Business Combination and NYSE Listing
/PRNewswire/ -- Securitize, Inc. ("Securitize" or the "Company"), and Cantor Equity Partners II, Inc. (Nasdaq: CEPT) ("CEPT"), a publicly traded special...
Joint statement – WHO/Europe and CCEE to collaborate on addressing health inequities and loneliness
WHO/Europe and the Council of Bishops’ Conferences of Europe (CCEE) officially signed a Letter of Intent on 23 June to establish a strategic partnership for promoting pan-European dialogue to reduce inequities, enabling every child and adult to live in health, safety and dignity.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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