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Microsoft explains why it still can’t fully kill Control Panel in Windows 11

Microsoft is phasing out the Control Panel in Windows 11 in favor of the Settings app, but the transition is careful due to old drivers.

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Apr 7 • 11:15 AM EDT • Technology • windowslatest.com
RFK Jr. rewrites rules on CDC panel after judge blocks vaccine changes

After a federal judge said members of the influential vaccine committee were "distinctly unqualified," an updated charter broadens the list of expertise for membership.

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Apr 7 • 9:43 AM EDT • Health • nbcnews.com
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UK government blocks rapper Ye from entering Britain to headline festival

i e bipolar-disorder antisemitism politics fairs-and-festivals world-news general-news entertainment | Talk Radio 1210 WPHT

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Apr 7 • 9:18 AM EDT • Entertainment • audacy.com
Kanye West blocked from traveling to UK following festival booking backlash

(CNN) — Kanye West has been blocked from traveling to the United Kingdom following controversy over the rapper’s planned appearance at a London music festival in July, according to the

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Apr 7 • 6:50 AM EDT • Entertainment • kten.com
Funky Monkey starts a new chapter after decades in same Magazine Street spot. Here’s why.

Funky Monkey’s new location is on the same street, on the same block and has the same square footage. So why’d the store move? Here’s the story.

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Apr 7 • 5:00 AM EDT • Entertainment • nola.com
Angel Reese trade: Atlanta Dream land All-Star from Chicago Sky in WNBA blockbuster

The Chicago Sky are moving on from Reese, the No. 7 pick in the 2024 WNBA Draft, after just two seasons

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Apr 6 • 11:37 AM EDT • Sports • cbssports.com
Lawmakers rethink school bus rules after fatal wreck: week in politics

The fatal Kenwood school bus crash made lawmakers rethink loosening safety rules. Plus, the House blocked a $20 million tax break for FedEx.

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Apr 6 • 6:02 AM EDT • Politics • tennessean.com
Scientists find hidden brain cells helping deadly cancer grow

Scientists in Canada have uncovered a surprising weakness in glioblastoma, one of the deadliest brain cancers. They found that certain brain cells—once believed to only support healthy nerves—can actually help tumors grow by sending signals that strengthen cancer cells. When researchers blocked this communication, tumor growth slowed dramatically in lab models.

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Apr 5 • 8:00 AM EDT • Science • sciencedaily.com
FULL SHOW: Inside INdiana Business 4/5/26

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Apr 5 • 8:00 AM EDT • Business • insideindianabusiness.com
Who are the kings being crowned here in Colorado?

Though most of us celebrate “No Kings Day” on July 4, the Trump-deranged got a head start last weekend with rallies around the state. Attendees bravely fought oppression by blocking traffic for people with jobs. Rally-goers demanded freedom from tyranny, many right after voting to ban all but beige house paint at their HOA meetings. […]

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Apr 5 • 7:00 AM EDT • Politics • coloradopolitics.com
Netflix, CBS, ABC & NBC Cancel 11 Popular Shows in 2026

Here are some of the television programs on the chopping block in 2026.

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Apr 4 • 10:42 PM EDT • Entertainment • mensjournal.com
Album Review: 6WA by BigXthaPlug & 600 Entertainment

BigXthaPlug spent eight months in Nashville making a country-rap album that debuted at No. 7 on the Billboard 200, put “All the Way” with Bailey Zimmerman at No. 4 on the Hot 100, got him a Rolling Stone cover, and filled arenas with Jelly Roll. And then he came back to Dallas, rounded up four of his signees, and made a gangsta-rap record with N.W.A’s Straight Outta Compton on the cover. 6WA is the second group release from 600 Entertainment, named after the 600 block of Meadowridge Street in Ferris, Texas, where BigX and his people grew up. The whole thing is loaded with West Coast samples. From N.W.A.’s “8Ball,” Eazy-E’s “Real Muthaphuckkin G’s” and “Boyz-N-The-Hood,” Ice-T’s “6 in the Mornin’,” Snoop Dogg’s “Nuthin’ but a ‘G’ Thang” and more. BigX is staking his name on the lineup he built—Rosama, MurdaGang PB, Yung Hood, KevanGotBandz, KaineMusic—and claiming a lineage from 1,400 miles away while insisting Dallas is its own thing. A million dollars in cash, split and handed straight to his mother. That’s the first place BigX goes on “From the Bottom.” He’d probably still be in the streets if he didn’t have his son and daughter. He only started rapping to make life better for Carter. Couldn’t start his car back then, now people get starstruck at Starbucks, and he throws the whole field away in one sentence: “How you think we competin’? You on the same bag, I just made me some millions off country.” Goyard bags off a Nashville payday, and he wants you to know exactly how far he’s come from everybody else. “Safe to Say” does something similar but looser. It’s a straight Ice Cube “It Was a Good Day” flip, and BigX nails it. Wakes up, checks both phones, nobody’s locked up, kid accounts look good. Gets pulled over, only catches a warning. Pulls up on the squad to liquor, ladies, and haze. Rosama takes the second verse and matches him. Wakes up to his girl cleaning his cuticles, twins playing peekaboo, pays off his car, calls a cousin, sees the opps and they don’t trip. Lawyer calls, he beat his case. Rosama is the strongest voice in the 600 camp after BigX, and “Life of a Gangster” is why. Third person, riding low, blacked-out windows, snub-nose revolver. A character who chose sticking people up over selling dope. “Quick eraser like a number-two pencil.” He never breaks character, and his delivery drops lower and slower than anything he does on the group cuts, like he’s telling you something at a cookout that he probably shouldn’t. Then on “Long Live Fre$h” he’s a completely different rapper. “Short-bus diamonds, these bitches retarded,” wide-body Durango he can’t even park. That kind of range matters on a group record. MurdaGang PB’s best verse is on the title track. Feds at his door at 6 AM, cameras busted, flushing dope, ram truck putting everybody on the floor. Yung Hood on “The Hottest” just lays out four reasons to keep hustling. Who wants to be broke, women cost money, you need bail, and home has to be straight. It’s funnier and more honest than most rappers get when they’re trying to explain why they sell drugs. KevanGotBandz on “Ain’t Never Slowin’ Down” talks about his father getting caught on the dope while he’s sitting on $300K somewhere in the hills, which is a specific kind of guilt that doesn’t usually make it onto crew tapes. KaineMusic, the newest signee, takes the back half of “Who Dunnit” and introduces herself in third person—“Took flight just to show these hoes how to perform”—but it’s too short to know if she can hold a full song. The flex tracks fill the middle of the LP and mostly run together. “I Go” is Rosama and PB trading brands, guns, and food punchlines. Rosama’s “anemic, my iron tucked low in this shirt” is a slick gun bar, PB fires back with “.223 with a clip ‘bout as big as a toddler” and “I go Burger King, stay with that whopper.” Quick, funny sometimes, but it’s all shopping lists. “Dopeman” is a chant. “6ixer Party” brings Snoop Dogg, who does exactly what you’d expect Snoop Dogg to do. BigX contributes the night’s wildest overshare: “She say she brought a friend too, well, I’m tryna put sausage on her dental.” These songs move fast and don’t overstay, but three or four of them could trade verses and nobody would catch it. Midway through, The D.O.C. shows up for a spoken-word interlude. Tracy Curry. West Dallas native, former N.W.A affiliate, co-writer on a lot of the records getting sampled on this very album. He thanks BigX for the tribute and then gets direct: “This your time, this DFW time. You need to do it like we do it down here.” Leave bread crumbs so everybody behind you can eat. Keep God in your life. It’s fatherly and generous, and it does raise the question of whether 6WA follows that advice. The album borrows heavy. The cover art, the Eazy-E samples, “Amerikkka’s Most Wanted” opening with a direct “Boyz-N-The-Hood” lift, Yung Hood rapping “Flag on my left side, Crip until I die.” But the stuff that actually stays with you is Dallas. BigX talking about Pleasant Grove, Rosama calling himself a country boy, PB recounting a raid that could’ve been last Tuesday. The record smells most like itself when it smells like Ferris, Texas, and least like Compton. BigX on “The Hottest” says his father was the first person he knew who had chickens. Not the way rappers usually wave at the drug trade. He means his actual father, his actual family. On “600 Degrees,” Rosama compares his chopper’s stutter to a speech disorder, PB claims he still has the block on his back even after leaving the city. BigX closes that one saying he used to spin and smack, and now the plaques are platinum. Thirty-two minutes was right for this. Nobody overstays, Tony Coles and Rance and Charley Cooks keep the production punchy, and BigX gives his signees real room instead of crowding every song. 6WA doesn’t reinvent anything. Five rappers, good beats, short clock. Most of what they say you’ve heard before. Some of it—the million to his mother, the cuticles and peekaboo, the four reasons to hustle—you won’t forget. Solid (★★★½☆) Favorite Track(s): “Safe to Say,” “From the Bottom,” “The Hottest” Subscribe

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Apr 4 • 8:03 AM EDT • Entertainment • shatterthestandards.com
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UC execs’ ties to vendors draw scrutiny as Calif. lawmaker pushes ban

A new bill would block UC executives from being paid by university vendors, a first-in-the-nation proposal targeting potential conflicts of interest.

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Apr 4 • 7:00 AM EDT • Business • sfchronicle.com
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Meta, Block rebrand some managers as 'org leads' and 'player-coaches'

As AI reshapes how work gets done, Meta and Block are doling out new job titles without the word 'manager.'

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Apr 4 • 5:48 AM EDT • Business • businessinsider.com
How Scientifically Accurate Is ‘Project Hail Mary’? Experts Weigh In

Based on hard science fiction, a genre that prioritizes scientific accuracy, the blockbuster gets a lot right but misses a few things, experts say.

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Apr 4 • 5:01 AM EDT • Science • nytimes.com
'Just don’t let her score': Betts delivers game-saving block for UCLA

UCLA center Lauren Betts' crucial block secured a 51-44 Final Four win over Texas, sending the Bruins to their first NCAA national championship game.

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Apr 4 • 3:20 AM EDT • Sports • usatoday.com
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Meteor impacts may have sparked life on Earth, scientists say

Asteroid impacts may have helped kick-start life on Earth by creating hot, chemical-rich environments ideal for early biology. These impact-generated hydrothermal systems could have lasted thousands of years—long enough for life’s building blocks to form. Scientists now think these environments may have been common on early Earth, making them a strong candidate for where life began. The idea could also guide the search for life on other worlds.

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Apr 3 • 8:00 PM EDT • Science • sciencedaily.com
Acting CHA leader tells staff it’s business as usual, defying Johnson’s attempt to block CEO hire

Matthew Brewer's insistence to move ahead despite the mayor efforts to remove him makes it clear Johnson will have to pursue legal action or otherwise convince a supermajority of the CHA’s board to reverse course.

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Apr 2 • 7:01 PM EDT • Business • chicagobusiness.com
Large police, SWAT presence blocks off street in Over-the-Rhine

A large police and SWAT presence is blocking a street in Over-the-Rhine Thursday.

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Apr 2 • 5:37 PM EDT • Health • wlwt.com
Democrats sue to block Trump's executive order targeting mail ballots

Democrats sued Wednesday to block President Donald Trump's latest executive order restricting mail voting, arguing that the U.S. Constitution empowers states and Congress, not the president, to determine who is eligible to vote by mail. The lawsuit marks the second round of battles over the president's power to control elections. Trump's opponents handily won the first round last year, blocking his initial executive order intended to reshape election procedures by convincing multiple federal judges that

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Apr 2 • 3:24 PM EDT • Politics • pbs.org
SoFi Deepens Blockchain Efforts With Business Banking Offering

SoFi is expanding its blockchain efforts with the debut of its Big Business Banking tool. The new offering is designed to let businesses manage fiat and

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Apr 2 • 8:16 AM EDT • Business • pymnts.com
EXCLUSIVE: RI Political Shake-up — Ken Block Launches Campaign for…

Rhode Island's political landscape is getting a reset.

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Apr 2 • 4:00 AM EDT • Politics • golocalprov.com
Democrats sue to block Trump's executive order targeting mail ballots

Democrats have sued to block President Donald Trump’s latest executive order restricting mail voting

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Apr 1 • 10:23 PM EDT • Politics • washingtonpost.com
Cannabis businesses sue to block Mass. anti-pot ballot question

Four cannabis business owners allege the ballot question would unconstitutionally end state programs that help to fund and support enterprises like theirs.

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Apr 1 • 4:55 PM EDT • Business • bostonglobe.com
Politics Keeps D.C.’s Autonomous Vehicles Roadblocked

AVs are safe, but politics as usual prevent their rollout in the nation’s capital.

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Apr 1 • 8:02 AM EDT • Politics • city-journal.org
Politics Keeps D.C.’s Autonomous Vehicles Roadblocked | The Foundation for American Innovation

Autonomous vehicles (AVs), in development for years, have only recently become safe enough for mass adoption. Now, events like Uber’s new partnerships with AV companies

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Apr 1 • 8:00 AM EDT • Politics • thefai.org
The Block in Bloom: Spring market pop-ups energize historic Black business district

Throughout the spring, entrepreneurs will flock to The Block — the historic heart of Asheville’s Black business and cultural district — for the Ujamaa Marketplace. The monthly, recurring vendors’ market launched in March and will continue to run through May, with a final special all-day gathering set for Juneteenth. On this week’s cover, starting left, alexandria ravenel, Aisha Adams and Ramona Young.

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Apr 1 • 7:00 AM EDT • Business • mountainx.com
How RFK Jr.’s MAHA agenda keeps hitting roadblocks

HHS Secretary Robert F. Kennedy Jr. over the last several months has suffered a series of setbacks that have sapped his influence within the GOP and left him diminished within the Trump administration.

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Apr 1 • 6:00 AM EDT • Politics • cnn.com
Are the Knicks heading for a postseason roadblock?
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Apr 1 • 2:16 AM EDT • Sports • sports.yahoo.com
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Exclusive: SpaceX lines up 21 banks for mega IPO, code-named project Apex

SpaceX is working with at least 21 banks on its blockbuster initial public offering, people familiar with the matter said on ​Tuesday, one of the largest underwriting syndicates assembled in recent ‌years.

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Mar 31 • 8:10 PM EDT • Business • reuters.com
The food business is changing, says Jim Cramer

'Mad Money' host Jim Cramer talks M&A activity in the food sector.

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Mar 31 • 7:35 PM EDT • Business • cnbc.com
Citing First Amendment, federal judge blocks Trump order to end funding for NPR and PBS

f w e n politics journalism public-media business entertainment washington-news general-news | Talk Radio 1210 WPHT

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Mar 31 • 4:37 PM EDT • Entertainment • audacy.com
Judge Blocks Deal Allowing Churches to Endorse Political Candidates

The Trump administration had sought looser rules for religious groups.

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Mar 31 • 4:09 PM EDT • Politics • wsj.com
Citing First Amendment, federal judge blocks Trump order to end funding for NPR and PBS

f w e n politics journalism public-media business entertainment washington-news general-news | WWL

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Mar 31 • 3:09 PM EDT • Entertainment • audacy.com
Judge rules that White House ballroom construction ‘has to stop!’

A federal judge on Tuesday blocked President Donald Trump from moving ahead with any further work on a massive new ballroom on the former site of the White House’s East Wing.

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Mar 31 • 3:06 PM EDT • Politics • cnn.com
Jack Dorsey: AI will turn managers into 'player-coaches' at Block

Jack Dorsey and Roelof Botha outlined Block's AI future one month after its sweeping 40% layoffs. Block will be a "mini-AGI," they wrote.

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Mar 31 • 2:58 PM EDT • Business • businessinsider.com
Judge blocks Trump order to end funding for NPR, PBS

The judge says the First Amendment right to free speech "does not tolerate viewpoint discrimination and retaliation of this type"

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Mar 31 • 2:33 PM EDT • Politics • spectrumlocalnews.com
The best headphones for flying, according to our frequent-flyer editors

Frequent flyers know great headphones aren’t optional; they’re essential. With more than 200,000 miles flown annually, I rely on them to block noise, reduce fatigue and make every flight more comfortable.

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Mar 31 • 12:00 PM EDT • Technology • cnn.com
Ms. Basketball has the latest in entertainment headlines

Brandy has a star on the Hollywood Walk of Fame and Zendaya is gearing up for another blockbuster movie release

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Mar 31 • 11:14 AM EDT • Entertainment • fox5atlanta.com
Quantum magnetism: FSU researchers demonstrate spin-flip process in atomic nucleus does not account for all magnetic behavior

In the air people breathe, the water on the Earth, the stars in the sky and more, atoms are the building blocks that make up the universe. Understanding

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Mar 31 • 8:00 AM EDT • Science • news.fsu.edu
Fire involves more than 30 vehicles in lot at S. Wichita business

The fire to the auto auction business in the 4500 block of South Madison, near K-15 and East 47th Street South was reported about 4:20 am. Tuesday

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Mar 31 • 6:15 AM EDT • Business • kwch.com
New Discovery Challenges Long-Standing Theory On The Formation Of The Earth – Its Building Blocks Came From Right Here

New analysis suggests that Earth’s material originates exclusively from the inner Solar System.

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Mar 31 • 5:44 AM EDT • Science • iflscience.com
San Francisco making it easier for businesses to host block parties
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Mar 30 • 10:17 PM EDT • Business • cbsnews.com
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Bulls make shocking Jaden Ivey decision after rant, blockbuster trade

Jaden Ivey played four games for the Chicago Bulls after he was acquired in a blockbuster three-team trade involving the Detroit Pistons and Milwaukee Bucks. MORE: Warriors’ Moses Moody suffers serious knee injury on dunk attempt Then he went off…

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Mar 30 • 5:41 PM EDT • Sports • sports.yahoo.com
New York looking to impose new gambling safeguards

Gov. Kathy Hochul has previewed sweeping new measures that would block minors from accessing betting apps and limit how companies target users.

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Mar 30 • 5:23 PM EDT • Politics • spectrumlocalnews.com
San Marcos arson killing suspect got mental health diversion plan instead of jail

Luis Alvarado, 33, was arrested on charges of murder and arson after the midnight fire in the 900 block of Lacebark Street.

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Mar 30 • 4:23 PM EDT • Health • nbcsandiego.com
What do you want to know about beta-blockers?

For decades, beta-blockers have been commonly prescribed as a standard treatment for adults who have had heart attacks with no complications and many people continue the medications for life. But a growing body of research has begun to question that approach.

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Mar 30 • 3:36 PM EDT • Health • cnn.com
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HPD searching for suspect who stole from local business

On March 21 at approximately 2:45 a.m., HPD says a person broke into Mr. Smoke Shop in the 800 block of 10th Street in Huntington.

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Mar 30 • 2:13 PM EDT • Business • wsaz.com
Bluesky's new AI tool Attie is already the most blocked account other than J.D. Vance

More than 125,000 Bluesky users have blocked Attie in just a few days, sending a strong message from the user base.

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Mar 30 • 2:03 PM EDT • Technology • techcrunch.com
After a heart attack, beta-blockers are often a lifelong medicine. Maybe they shouldn’t be

For decades, surviving a heart attack has come with a lifelong prescription: Stay on medications called beta-blockers to help protect your heart. But doctors are taking a closer look at whether long-term beta-blocker use is really necessary, especially beyond the first year of recovery.

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Mar 30 • 9:30 AM EDT • Health • cnn.com
Big Tech joins Big Oil as big CA politics spenders

Tech companies spent $39 million to influence California politics last year, making 2025 a blockbuster year of spending for Meta, Google and others.

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Mar 30 • 9:00 AM EDT • Politics • calmatters.org
Donald Trump says he has no problem with Russian tanker bringing oil to Cuba despite blockade

'It’s not going to have an impact. Cuba’s finished.'

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Mar 30 • 7:36 AM EDT • Politics • floridapolitics.com
Rep. Carringer blocks testimony on maternal health bill

A Planned Parenthood organizer writes: I was blocked from testifying on how pregnant women in Tennessee are being denied care.

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Mar 30 • 5:04 AM EDT • Health • knoxnews.com
Orlando Storm debut with 23-16 UFL victory over Columbus

A block in the back could have been a nightmare for Chris Rowland and the Orlando Storm on Sunday night at Inter&Co Stadium during the the team’s UFL debut game. Rowland, a Storm receiver, was trailing on a play as teammate Elijhah Badger was speeding down the field on the way to a 94-yard touchdown off a screen pass. Rowland, however, clipped a Columbus Aviators’ player in the back and flags ...

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Mar 30 • 1:14 AM EDT • Sports • sports.yahoo.com
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Blockbuster trade proposal sends Alex Highsmith to NFC

Could the Steelers trade Highsmith ahead of the draft?

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Mar 29 • 5:20 PM EDT • Sports • sports.yahoo.com
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Jackknifed big-rig catches fire, blocks ramp at Business 80, Highway 50 in Sacramento
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Mar 29 • 1:56 PM EDT • Business • cbsnews.com
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Science Central unveils new planetarium

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Mar 29 • 10:50 AM EDT • Science • insideindianabusiness.com
FULL SHOW: Inside INdiana Business 3/29/26

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Mar 29 • 8:00 AM EDT • Business • insideindianabusiness.com
Hingham Schools Eye Business Curriculum Expansion as Class Size Concerns Mount

HINGHAM - March 23, 2026 - The Hingham School Committee moved to modernize its high school offerings Monday night, reviewing a comprehensive plan to expand the “small but mighty” Business Department while simultaneously grappling with data that places Hingham as an outlier in elementary class sizes. Director of Social Studies Andy Hoey presented a two-year program review that highlighted the department’s success in community partnerships but warned that high student demand is testing current staffing limits. Meanwhile, committee Chair Jen Benham presented independent research showing Hingham is the only benchmark district with second-grade classes hitting a 25-student cap, sparking a directive for the Policy Subcommittee to review class-size standards. Editors note: South Shore News is going paid in April, subscribe now to make sure you don’t miss a story. Reach out for group or organizational pricing. Subscribe The Full Story The meeting opened with a look into the future of Hingham High School’s (HHS) curriculum. Andy Hoey, who oversees the Business Department, presented the first formal program review for the department since 2009. [15:09] Hoey characterized the department as a vital elective hub that currently serves between 14% and 27% of the HHS student body in any given year. [31:31] “We are very proud of our business department here at Hingham High School... while we’re very proud of it, we are always striving to make improvements and enhancements.” [15:55] — Andy Hoey, Director of Social Studies A key highlight of the presentation was the announcement of a new AP Business with Personal Finance course launching next year, pending enrollment. [20:08] The review team found that while the program is “well-aligned” to national standards, it remains a high-school-only offering. Hoey outlined an action plan to explore “vertical articulation,” potentially introducing business or financial literacy units at the middle school level to fill a “gap” identified between fifth and eighth grade. [41:48] However, the department faces “smoke and mirrors” regarding student GPA, according to Hoey. Currently, most business courses are “unleveled” and do not count toward a student’s GPA, which survey data suggests may deter some students from enrolling. [28:15] The committee discussed the possibility of offering Honors or College Prep (CP) credit for advanced courses, such as investing or marketing, to better reflect their academic rigor. [38:27] The discussion took a sharp turn toward elementary education during an enrollment update. Superintendent Dr. Katie Roberts noted a net gain of four students mid-year, but it was Jen Benham’s “rabbit hole” data analysis that caught the committee’s attention. [50:35] Benham researched 13 benchmark towns—representing 34 elementary schools—and found that Hingham was the only district with a second-grade section reaching 25 students this year. [51:36] Benham’s findings suggested that while many districts lack formal class-size policies, Hingham’s current cap of 25 for second grade may be too high. “I think if we could at least have 23 at a cap for grade two,” Benham suggested, noting the importance of that grade level for literacy development. [53:09], [54:55] Dr. Roberts cautioned that smaller classes require more staff, which is a significant hurdle following a budget season where nine general education positions were cut across the district. [55:56] The committee also finalized the 2025 Town Report, which was updated to be more “student-centered” and highlight staff early in the document. [11:12] Additionally, a series of food service policies were approved to align with Massachusetts’ universal free school meal mandate, including new protocols for meal modifications due to allergies or religious needs. [59:23] Share Why It Matters The meeting underscored a tension between Hingham’s desire to offer elite, specialized programming and the foundational pressure of class sizes. The expansion of the Business Department—including potential Microsoft certifications and AP courses—aims to prepare students for a “real world” where credit scores and financial literacy are paramount. [46:20] However, the revelation that Hingham’s second-grade classes are larger than those in all neighboring benchmark towns suggests a potential strain on early education that could impact long-term student performance if not addressed by the Policy Subcommittee. Official Minutes & Data Key Motions & Votes Motion: To approve the Hingham Public Schools 2025 Town Report. [13:16] Vote: Unanimous (7-0) ([01:13:28]) Motion: To approve the Memorandum of Agreement (MOA) for summer counselor work regarding course placement. [57:33] Vote: Unanimous (7-0) ([57:50]) Motion: To approve Policy EFBA (School Food and Nutrition/Meal Modifications). [01:00:32] Vote: Unanimous (7-0) ([01:00:44]) Motion: To approve Policy EFC (Universal Free School Meals). [01:00:54] Vote: Unanimous (7-0) ([01:01:07]) Public Comment No members of the public spoke during the meeting or via the remote link. [01:02:30] What’s Next The Policy Subcommittee will take up the review of elementary class-size caps over the next year to determine if the Grade 2 limit should be lowered from 25 to 23. [52:18] The Business Department will monitor enrollment for the new AP Business course and continue exploring dual-enrollment partnerships with Quincy College. [38:13] Source Video: Harbor Media South Shore News is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

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Mar 29 • 7:03 AM EDT • Business • southshore.news
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Albany block party connects residents through fun, food, and health resources

Albany block party connects residents through fun, food, and health resources

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Mar 28 • 5:25 PM EDT • Health • walb.com
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Louisville police say officers fatally shot woman in 'mental health crisis' who charged at them with sharp object

It happened at 7:45 p.m. Friday in the 9800 block of Vieux Carre Drive, off Shelbyville Road and South Hurstbourne Parkway.

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Mar 27 • 8:49 PM EDT • Health • wdrb.com
Studying human-robot interaction, CWRU researcher explores tech-enabled mental health support | CWRU Newsroom | Case Western Reserve University

Editor’s note: Jasmine Vo, the author of this story, is a student employee in the University Marketing and Communications department. She is a fourt...

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Mar 27 • 9:45 AM EDT • Health • case.edu
Judge temporarily blocks the Pentagon's action against Anthropic

Anthropic has said it could lose billions if a federal judge didn't step in to block the Trump administration.

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Mar 26 • 7:36 PM EDT • Business • businessinsider.com
Kennedy’s Vaccine Agenda Hits Roadblocks, Diminishing His Clout

Health Secretary Robert F. Kennedy Jr.’s vaccine skepticism is posing challenges for the Trump administration. Top health jobs are unfilled, and a court has blocked his vaccine schedule changes.

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Mar 26 • 7:31 PM EDT • Health • nytimes.com
3 shot in Central Business District Thursday afternoon, police say

NEW ORLEANS (WVUE) - Three people were shot in the 1400 block of Tulane Avenue in the Central Business District, and police detained one person on the scene, according to police.

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Mar 26 • 4:08 PM EDT • Business • fox8live.com
Schumer, Democrats say they support voter ID — then block GOP amendment to require it

Senate Democrats blocked a photo voter ID amendment to the SAVE America Act, despite Senate Minority Leader Chuck Schumer, D-N.Y., saying Democrats support voter ID.

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Mar 26 • 11:23 AM EDT • Politics • foxnews.com
Cuban Patients Are Dying Because of U.S. Blockade, Doctors Say

Cuban health care was once the pride of the island. Now the U.S. oil blockade is upending even basic medical care.

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Mar 26 • 5:01 AM EDT • Health • nytimes.com
Trump’s Threats to Europe Put Its Leaders in a Double Bind Over Iran

European politicians risk angering their voters if they join America’s war. Yet they could also face domestic upheaval if they take no action to reopen shipping routes that Iran has blocked and ease an energy crisis.

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Mar 26 • 12:01 AM EDT • Politics • nytimes.com
Wembanyama dominates inside as Spurs trounce Grizzlies 123-98

Victor Wembanyama had 19 points, 15 rebounds and seven blocks as the San Antonio Spurs built an early lead and coasted to a 123-98 victory over the Memphis Grizzlies on Wednesday night. Devin Vassell matched Wembanyama's 19 points, while Stephon Castle and Keldon Johnson finished with 15 points each, as seven Spurs finished in double figures. With its seventh straight victory, San Antonio moved within two games of Oklahoma City for the top spot in the Western Conference as the Boston Celtics stopped the Thunder's 12-game winning streak with a 119-109 victory on Wednesday night.

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Mar 25 • 10:40 PM EDT • Sports • sports.yahoo.com
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Apple blocks App Store updates for Mac app replacing Launchpad

Apple is blocking App Store updates to AppGrid for resembling Launchpad, a feature the company recently discontinued. Here are the details.

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Mar 25 • 9:06 PM EDT • Technology • 9to5mac.com
Lightning Round: Sell Penn Entertainment

'Mad Money' host Jim Cramer weighs in on stocks including: Qnity Electronics, Rigel Pharmaceuticals, Penn Entertainment, Applied Digital, and more.

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Mar 25 • 7:51 PM EDT • Entertainment • cnbc.com
Generac CEO: We want to be 50/50 as a residential and commercial business

Aaron Jagdfeld, Generac chairman, president, and CEO joins 'Mad Money' host Jim Cramer to talk the state of the energy market.

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Mar 25 • 7:35 PM EDT • Business • cnbc.com
Democratic lawmaker asks judge to take Trump's name off Kennedy Center

A Democratic lawmaker is asking a federal judge to force the Kennedy Center to block and reverse efforts to attach President Donald Trump’s name to the historic performing arts venue.

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Mar 25 • 6:19 PM EDT • Entertainment • yakimaherald.com
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Arsenal exploring blockbuster summer move for PSG’s Khvicha Kvaratskhelia

Arsenal are exploring a blockbuster summer move for PSG winger Khvicha Kvaratskhelia (25), according to The Independent’s Miguel Delaney. The winger has proved an immediate hit for Les Parisiens o...

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Mar 25 • 1:55 PM EDT • Sports • sports.yahoo.com
Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

Political donations in cryptocurrency could be blocked in blow to Reform UK

Government review also recommends political funding from Britons living abroad be capped at about £300,000 a year

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Mar 25 • 7:58 AM EDT • Politics • theguardian.com
Stephen Colbert to write next ‘Lord of the Rings’ movie after leaving late night

Stephen Colbert already has a new job lined up for when he ends his 11-year run as host of “The Late Show” in May – the comedian and well-known J.R.R. Tolkien superfan announced he will co-write and develop a new film in the blockbuster “Lord of the Rings” franchise.

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Mar 25 • 5:33 AM EDT • Entertainment • cnn.com
Snapdragon 8 Elite Gen 6, 8 Elite Gen 6 Pro specifications leaked well before official announcement

Leak reveals Qualcomm Snapdragon 8 Elite Gen 6 chips with 2nm process, dual variants, LPDDR6 support, and upgraded GPUs. Read more about expected specifications here

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Mar 24 • 10:58 PM EDT • Technology • gizmochina.com
The real roadblock to government formation in Iraq isn’t Maliki—it’s Kurdish power politics

A dispute between Kurdish factions presents a significant structural obstacle to Iraq’s government formation regardless of who is nominated for prime minister.

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Mar 24 • 4:07 PM EDT • Politics • atlanticcouncil.org
We disagreed on politics. We agreed on wine. That was enough.

At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.

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Mar 23 • 10:54 PM EDT • Politics • dmwineline.substack.com
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Demand for GLP-1 pills and shots surges, and not just for weight loss

Use of blockbuster anti-obesity drugs like Wegovy and Zepbound is growing, with about 1 in 8 adults in the U.S. saying they currently take the medications.

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Mar 23 • 7:52 PM EDT • Health • latimes.com
The Monday Outlook: Project Hail Mary and the Science Behind Blockbuster Sci-Fi

Project Hail Mary is the latest sci-fi blockbuster to stretch the bounds of audience imagination and stir the curiosity of real scientists. But the science driving films like Project Hail Mary, Interstellar and The Martian isn’t all fictional: at UChicago, researchers exploring the cosmos and decoding the origins of life are making discoveries that would feel right at home on the big screen. This week's Monday Outlook features scientists from UChicago and Argonne National Laborat

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Science Through Shadows: How Astronomical Alignments Reveal the Universe

When one celestial object passes in front of another, it can cast a shadow that travels across space – and sometimes across Earth. These moments of alignment, known as eclipses, occultations, and transits, allow scientists to study distant objects in remarkable ways. By observing how light changes when an object briefly blocks another, astronomers can measure sizes and shapes, detect atmospheres, and refine the orbits of asteroids and planets.

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Exclusive: Kalshi to block athletes and politicians from trading on their markets

Prediction market Kalshi plans to block athletes, coaches and officials from betting on their sports and to block political candidates from trading on their campaigns, Axios has learned.

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Trump’s Political Risk Insurance Plan for Ships in the Gulf Could Benefit China, Says Democratic Senator

President Trump’s $20 billion plan to provide political risk insurance for ships aimed at unblocking the Strait of Hormuz could end up ultimately

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Trump sued by historic preservation groups to block Kennedy Center changes

A coalition of preservation groups is suing to stop major physical changes at the Kennedy Center under President Donald Trump’s renovation plans. On Monday, the groups filed a lawsuit against

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A promising fatty liver treatment may raise cancer risk

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that without this enzyme, liver cells grow abnormally large and accumulate genetic damage, leading to inflammation, scarring, and eventually tumors, especially with age. While inhibiting Caspase-2 may offer short-term benefits, such as reducing fatty liver disease, the long-term consequences appear dangerous.

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Slovenia liberals take narrow election lead over conservatives: exit poll

Exits polls suggest Prime Minister Robert Golob has blocked a fourth term for right-winger Janez Janša

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Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
‘Project Hail Mary’ Author Andy Weir Bases His Blockbusters in Science

The bestselling writer and self-described “dork” explains how he crafts upbeat space-set thrillers from dire scenarios only expertise can solve.

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Mar 22 • 10:00 AM EDT • Science • rollingstone.com
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Winner and Loser of the Week in Florida politics

DeSantis signed a bill seeking to block a Manatee cruise port, while another Republican group is in hot water.

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Mar 22 • 5:30 AM EDT • Politics • floridapolitics.com
Senate blocks amendment on transgender athletes during weekend session

The amendment that was blocked by a 49-41 vote would create potential penalties for educational institutions that receive federal funding

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Democrats block SAVE America Act amendment to bar transgender athletes in women’s sports

Senate Democrats voted Saturday to defeat a Republican-sponsored amendment to the SAVE America Act that would prohibit transgender athletes from participating in girls’ or women’s sports, an …

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DNA building blocks on asteroid Ryugu, bacteria that eat plastic waste, and more science news

Catch up on some of the most interesting science stories from this week.

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Here's How You Can Watch Sports With a VPN

A VPN can enhance your sports streaming by unblocking regional matches, circumventing geographical limitations or bypassing throttling restrictions.

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Mar 21 • 8:00 AM EDT • Sports • cnet.com
One arrested, another cited in shoplifting incident at business on East Avenue in Chico

CHICO, Calif. - A Paradise man was arrested and a Forbestown woman was cited by Chico Police in connection to a shoplifting incident at a business in Chico.The Chico Police Department says that at around 12:30 p.m. on Wednesday, March 18, a loss prevention employee observed two suspects stealing several items from a retail business on the 700 block of East Avenue in Chico.Upon exiting the building, the two suspects, a man and a woman, were contacted by the loss prevention employee regarding the stolen items. The employee was able to persuade both suspects to return to the store and hand over the items they had stolen.Authorities say the business expressed their desire to press charges against the suspects and contacted Chico Police to report the crime.Officers reviewed video surveillance that confirmed the employee's account of what happened. Officers then made arraignment for both suspects to turn themselves in the following day.When the suspects, identified as 51-year-old Jamie Leal of Forbestown and 62-year-old Melvin Royal of Paradise, arrived the next day to turn themselves in, authorities say both admitted to their involvement in the incident and elected to write handwritten apology letters to the business.Leal was cited by Chico Police on a misdemeanor charge of shoplifting.Royal was taken into custody and transported to the Butte County Jail, where he was booked on the following charges:Shoplifting with 2+ priors (felony)Shoplifting (misdemeanor) googletag.cmd.push(function() { googletag.display('ad-1514992'); });

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Judge sides with New York Times in challenge to Pentagon policy limiting reporters’ access

A federal judge agreed Friday to block the Trump administration from enforcing a policy limiting news reporters’ access to the Pentagon, agreeing with The New York Times that key portions of the new rules are unlawful.

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Mar 20 • 6:39 PM EDT • Politics • pbs.org
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Scoop: Weight management company Wondr on the block

Both employer health costs and demand for GLP-1s are rising.

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Mar 20 • 4:39 PM EDT • Health • axios.com
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Federal judge sides with Washington in case over transgender youth health care

A federal judge said Thursday he will rule in favor of Washington state and a coalition of 20 other states and the District of Columbia, blocking what they call

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Family-focused venue The Block Jax opens in Deerwood with food vendors, live music, dog park & more

Whether you want to catch the big game or take the family out for a night, The Block Jax, Jacksonville’s first outdoor food hall, made its debut on Friday with a grand-opening celebration continuing through Sunday.

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Mar 20 • 12:41 PM EDT • Entertainment • news4jax.com