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Poor leaders can tank employees’ mental health (and the company); his business summit puts workplace culture
“I’m a big believer in human to human connection because there’s so much loneliness and isolation happening,” explained Ebrima “Abraham” Sisay, host of the You Gotta No! Podcast (YGN) and its annual YGN Summit. “That’s because we’re getting further away from what we are meant to do as humans.”
Anxiety over fuel prices points to ‘looming EV comeback’ in U.S.
Just when it seemed American car buyers had left electric vehicles for dead, there are new signs of life in that corner of the auto market.
What big shows are coming up in Utah? Here’s the latest
Here’s a breakdown, by venue, of big shows to watch out for the rest of this year
5 faith-filled, family-friendly movies streaming this fall
For viewers looking for faith-filled and family-friendly entertainment as the weather cools down, here are five films making their way to streaming platforms, with stories of faith and courage
College volleyball rankings after Week 6: Updated AVCA Coaches Poll
Here's the latest AVCA Coaches Poll after the last week's worth of games during the 2026 women's college volleyball season.
Your ballot, your move: Early voting starts Oct. 6
By Kevin Hendricks, nm.news — New Mexico voters can start casting ballots Oct. 6 for the Nov. 3 general election. There’s no reason to wait in line on Election Day, or to walk into the booth guessing. Early voting opens Oct. 6 at county clerk offices. On Oct. 17 it expands to more locations across […]
Pre-Columbian Archaeology Meets Science Fiction in Max Lehman's Quirky Sculptures
Max Lehman delves into a kind of future past inspired by science fiction, where modern tech and prehistoric visual culture merge.
Upgrade to Apple Watch Series 12 or Ultra 4? Here’s how to get the most out of it
Upgrade to a new Apple Watch Series 12 or Ultra 4? Apple Watch Series 12 and Ultra 4 bring upgraded...
How a controversial camera system is monitoring mental health patients
The Lampard Inquiry started back in September 2024 and I remember going to the first hearing in Chelmsford. Subscribe The bereaved families made placards of their loved ones, they stood outside in silence and then laid flowers to mark the moment. Now, two years on, in a process meant to last another two years, there’s been a development. Last week, we were told the chair, Baroness Lampard, pictured below, could be looking at making interim recommendations. Throughout the process, she has remarked that although this inquiry is looking at almost 2,000 people who were under the care of Essex mental health services from 2000-2023 when they died, the findings could have national implications for other trusts. ‘Records 24 hours a day in patient’s bedroom’ So why has this happened? One system that the inquiry is going to take a closer look at is a controversial monitoring system called Oxevision. It monitors some vital signs of patients remotely by using a camera placed in a room. It’s used by 40% of NHS mental health trusts. But campaigners, particularly the group Stop Oxevision, have asked for this technology to be removed from mental health wards as soon as possible. I spoke to a member, Hat Porter, today and they described to me what they thought this technology did and explained their concerns: “It records 24 hours a day and it’s located in a patient’s bedroom, which is obviously somewhere you’d usually expect to be a private place. “Our concerns are that the use of the technology has been has been kind of implemented as a substitute for proper in-person support, that it’s kind of over relied on and that there’s a lot of misunderstandings and that the presence of a camera, which has often been used without people’s consent, sometimes without even their knowledge, that that has a really big impact on privacy, dignity and human rights.” ‘Not sufficient’ I put it to them that the company behind Oxevision would dispute their claims about consent and in videos I’ve seen online from NHS trusts, they make it clear that the technology is complementary to trained staff and not a replacement. [ ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) [ How the Nottingham inquiry shines a spotlight on other key mental health care failings ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) Victoria Macdonald · Feb 12 [ Read full story ](https://channel4news.substack.com/p/the-nottingham-inquiry-what-lessons) A team of lawyers has been working on the inquiry and with bereaved family members who have concerns about this technology. I spoke to solicitor Priya Singh, from Hodge Jones & Allen, who made the point that questions usually asked by nurses would be missing from using devices like this. “It’s not sufficient to say, oh, the patient is moving around. Somebody must go in and say, are you okay? Are you distressed? Do you want help? Is there anything I can do? Share Channel 4 News “How are you spending your time? So I think a lot of our families cannot see the function of it when ultimately the patient should only really be observed when they’ve been prescribed to be observed, they can be observed more, but that more should really be happening face to face.” The Chair will hear evidence over the next two weeks and then a decision made after that, which could have national impact if she does decide this technology should be investigated or even removed. The Department of Health and Social Care said: “The Government is committed to ensuring that lessons are learned from the Lampard Inquiry to improve patient safety. “We are confident that the Inquiry will play an important role in identifying wider learnings for the health system following the tragic events in Essex and will contribute to improvements in patient safety.” We approached LIO Health, which runs Oxevision, for comment. Subscribe Share Channel 4 News Leave a comment
Layla Zaidane: The politicians who can fix America’s polarization problem will win
Political predictions are notoriously unreliable, but here is one I am willing to stand behind: the elected officials who figure out how to govern across difference will dominate the next decade of American politics. With dysfunction and paralysis having become the status quo in Washington, elected officials who work together
Bones About Town takes over Main Street
Spooky season has made its way to Main Street — along with some new residents. Skeletons have taken over lampposts along the street, where they’ll live for all of October.
Sphere Entertainment Sinks 12% on Analyst Downgrade: Demand “Softening Faster Than Expected”
Sphere’s own ticket-sales milestones show the same slowdown the analyst sees
Why Sphere Entertainment (SPHR) Stock Is Trading Lower Today
What Happened? Shares of content production and distribution company Sphere Entertainment (NYSE:SPHR) fell 12.3% in the afternoon session after Craig-Hallum ...
Northwell Health lays off 'limited number' of workers across the organization
The health system, which employs over 100,000 statewide, did not specify where cuts were made.
Stock up/stock down for Kentucky after beating South Carolina
The Kentucky football team got a comeback win over South Carolina this week. Here's whose stock is soaring, and whose isn't afterwards.
Review: Metallica lives the dream on opening weekend of Sphere residency
LAS VEGAS — “I had a dream last night,” Metallica singer James Hetfield said. “We were playing the Sphere. “So cool.” Indeed, it was, James. Yet, it wasn’t a dream.
No stadium has a story like the Superdome
The Superdome has weathered the highest of highs and the lowest of lows to represent the complicated and celebrated history of its city.
'Flew Here Grew Here' talks trending entertainment topics
Olivier Martinez claims Halle Berry assaulted their 12-year-old son, Maceo, alleging she choked him and yelled "Who is dominant now?"
Sphere Entertainment options flow analysis amid an 11.6% stock drop
Sphere Entertainment options flow analysis amid an 11.6% stock drop
10 cool and cozy books for fall - Entertainment
Temperatures are cool, the couch is cozy, and the season’s greatest reads are calling your name. Here are 10 books to curl up with this fall.
Netflix’s #1 Movie Has Viewers Ugly Crying
Netflix’s #1 movie is leaving viewers reaching for the tissues. Find out more here.
Claims that genAI speeds up PC ports of classic games are either "false" or missing the point, says Banjo Kazooie: Recompiled developer
A Banjo Kazooie: Recompiled developer has spoken out against the idea that generative AI allows for faster PC ports and, therefore, better preservation.
Here's What Capcom Said About Using Generative AI In The RE Engine: 'AI Is Not A Replacement For Humans'
Capcom want to evolve RE Engine into an engine for the AI generation, but not turn it into an engine powered by generative AI over humans
Traders Purchase Large Volume of Call Options on Sphere Entertainment (NYSE:SPHR)
Sphere Entertainment Co. (NYSE:SPHR - Get Free Report) saw unusually large options trading activity on Monday. Traders bought 9,775 call options on the company. This represents an increase of 1,615% compared to the typical volume of 570 call options.
Can Health Trackers Help You Manage Menopause Symptoms?
Apple, Oura and Whoop have all recently added features for midlife women. Here’s what the tools can — and can’t — measure.
USA TODAY Sports Super 15 East region football rankings, Week 8
Here are the latest USA TODAY Sports East Region rankings following a wild week of high school football action.
Scientists seek new ways to protect Sierra Nevada meadows
Sierra Nevada meadows may cover a relatively small portion of the landscape, but scientists say they play an important role in supporting wildlife, storing water and maintaining biodiversity. Researchers and conservationists recently gathered at the...
'Here & Now' Highlights: Charles Franklin, Jason Stein
A month before the 2026 election, the Marquette Law School Poll shows candidates for governor neck-and-neck — poll director Charles Franklin explained where voters stand and why. Enrollment caps for ...
Sphere Entertainment (NYSE:SPHR) Shares Gap Down Following Analyst Downgrade
Sphere Entertainment (NYSE:SPHR) Shares Gap Down Following Analyst Downgrade
Seedy K’s Pigskin Palaver: House of Cards & Much Mo’
Ah yes, October; the pigskin campaign is morphing more fully developed. And, fully enveloping. This week, there’s a football game on every single night. Not just the more traditional Thursday, Friday, Saturday, Sunday, Monday. Because Draft Kings and Fan Duel and The World Wide Leader need content, we get Southern Miss and Troy on Tuesday, […]
Reba McEntire, Ella Langley, Kelsea Ballerini will perform at Dolly tribute
ABC's Dolly Parton tribute unites music's biggest names, from Carrie Underwood to Vince Gill. Here's how to get tickets.
WATCH LIVE: Trump campaigns with Ricketts in Nebraska, where ranchers have beef with his import plan
The AFC road to L.A. may go through Duval
As the stadium in Jacksonville undergoes renovations, the Jaguars will play only six games there in 2026.
GTA VI Writers Sidestep Trump and MAGA, as Rockstar’s Rupert Humphries Says Florida Satire Targets Conspiracy Theories Instead
Rockstar said there won't be any references to specific trends or persons in GTA VI, as the game focuses on stuff like conspiracy theories.
Permits issued for $22 million Perkins Road elementary school, new Southern Classic Chicken location
Here is a list of commercial and residential building permits issued by East Baton Rouge Parish Government from Sept. 28-Oct. 2.
Top Athletes: J|medical Brings Excellence in Sports Medicine to Allianz Stadium
On 2 and 3 October, Allianz Stadium hosted the second edition of “Top Athletes: Where Excellence Meets Evidence”, the International Congress promoted by J|medical, which brought together in Turi...
Boomers, Science Has Good News About Your Farting Habits
Based on self-reported results, millennials and Gen Xers fart more often than baby boomers. But there are reasons why seniors may have increased flatulence.
Spain’s New Protest Movement Is Putting Class Center Stage
The occupation of Madrid’s Puerta del Sol by housing protesters has brought back memories of the anti-austerity revolt that began in 2011. But where the Indignados used generic populist language, this...
2026 Outstanding Women in Business
The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.
Neighborhood Intelligence Provides Business Update and Announces $45.5 Million Equity Financing with Participation from Management and a Single Institutional Investor
NASHVILLE, Tenn., October 05, 2026--Neighborhood Intelligence (NASDAQ: NXH) ("Neighborhood" or the "Company") today announced that it has entered into a definitive agreement for the purchase and sale of an aggregate of 16,485,508 shares of its common stock (or pre-funded warrants in lieu thereof) at a purchase price of $2.76 per share (or pre-funded warrant in lieu thereof) in a registered direct offering. In addition, the Company will issue warrants to purchase up to 16,123,189 shares of common
Sphere Entertainment (NYSE:SPHR) Downgraded by Craig Hallum to "Hold"
Craig Hallum lowered Sphere Entertainment from a "buy" rating to a "hold" rating and set a $132.00 price objective for the company. in a research report on Monday.
DeSean Bishop Is the X-Factor Arkansas Must Contain
Arkansas knows exactly where Tennessee’s offensive plan begins. It begins with DeSean Bishop. The Volunteers running back enters Fayetteville after one of the best performances in the country this season. Bishop rushed 34 times for 220 yards and three touchdowns in Tennessee’s 24-14 win over Auburn, turning a game with quarterback uncertainty into a statement …
Is CBIZ (CBZ) Outperforming Other Business Services Stocks This Year?
Here is how CBIZ (CBZ) and GigaCloud Technology Inc. (GCT) have performed compared to their sector so far this year.
From 4-H Member to Healthcare Leader: A Conversation with Davina Ferrero King
"My 4-H experience helped establish UConn in my mind as a place where I could continue growing academically, professionally, and personally."
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | WBBM Newsradio 780 AM & 105.9 FM
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk 1370
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | KNSS Radio
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | Talk Radio 1210 WPHT
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago | 1010 WINS
PEN America: Nearly 12,000 school book bans in a year, a record high
A new study from PEN America reveals that there were nearly 12,000 book bans in public schools over the past year, the highest since tracking began five years ago.
Takeaways from Bills loss to Patriots
Here’s what I took away from the Bills home loss to the Patriots
Eagles’ 14-Year NFL Veteran Gets Honest On ‘Overwhelming’ Start
Week 4 against the Los Angeles Rams served as the second game for Zach Ertz’s second stint with the Philadelphia Eagles. It was the first time Ertz donned Eagles green at home in South Philly in years. As expected, there was a lot of love shown to Ertz when he scooped up his first catch […] The post Eagles’ 14-Year NFL Veteran Gets Honest On ‘Overwhelming’ Start appeared first on HEAVY.
ACSH in the Media: Yahoo News, RealClear, Science & Culture, and More
From cancer and cannabis to perverse research incentives, we’ve been busy confronting nonsense. Here’s a roundup of recent media appearances and pickups featuring ACSH experts across the web, including coverage in Yahoo News, RealClearHealth, RealClearScience, and Science and Culture.
NBA executive: 'There's definitely interest' in Bronny James
If the Lakers are willing to listen to offers, they could get back some value in a trade for Bronny James.
Back to The Ballroom: Yacht Rock Night
On Sept. 29, 2026, the “Dancing with the Stars” ballroom transformed into relaxing vibes and good times for yacht rock night. While there was smooth sailing, the 13 couples experienced some turmoil on the dance floor.
Collaborating with Canadian Scientists on Marine Carbon Dioxide Removal Research
I first met Dr. Helen Gurney-Smith in fall 2024, when Dr. Shannon Meseck and I drove just beyond the U.S.-Canada border to the St. Andrews Biological Station in New Brunswick. We went there to study larval sea scallop respiration when exposed to near-future temperature and pH. This past winter, Dr.
Here’s Exactly How Often to Eat Fish to Support Brain Health, According to a Dietitian
In TODAY.com’s Expert Tip of the Day, a dietitian shares how to get the brain-boosting benefits from eating fish regularly.
Business Ingenuity Gives Birth to Edgy, an AI Agent Educated in the Theory Behind Natural Synergy™ to Show Leaders Where Their Organizations Are Headed
SAN FRANCISCO, October 05, 2026--Business Ingenuity, Inc. today announced the availability of Edgy, an AI agent educated using Natural Synergy: From Natural Mystery to Mastery, co-authored by co-founder Charles Follett and Ray Scott and available on Amazon. Edgy analyzes an organization through its public footprint and its own people, then tells executives which Operating State the organization occupies, which direction it is being driven, and what adjustments would improve its performance.
KUNC's 2026 midterm election voter guide for Northern Colorado
Everything Northern Colorado voters need to know about the state’s midterm election, including major races, ballot measures, voting deadlines, how to return your ballot, and where to find trusted election resources.
5 tax measures are on the California ballot. Here’s how to make sense of them all
California voters haven’t had to make so many decisions about tax policy at the ballot since 1994. Our analysis shows voters to reject new taxes.
The Business of Civility
In an ever-coarsening world where even hosts on the bastion of conservative media, Fox News, are now using profanity on a regular basis, there is still one place where civility is demanded—and usually delivered. And that place is the business community. Whether you’re ordering a meal at McDonald’s or interviewing the wealthy CEO of Mississippi’s […]
Jets at Bears: Full highlights from Week 4
Check out all the highlights from the Jets vs. Bears in Week 4 right here.
Ground Zero Blues Club
A Labor of Love for its Three Managers It is no mystery why Ground Zero Blues Club (GZBC) is one of the most famous blues clubs in the country. It is a genuine juke joint where customers are treated to great live music along with genuine hospitality serving up Southern food favorites like barbecue […]
'There's not a better time to turn pro'
Commonwealth Games silver medallist Connor Williams feels there is no better time to fulfil his lifelong ambition to be a professional boxer.
Are aliens real? Here’s what science can and can’t prove
Some scientists believe the sheer number of stars, planets and potentially habitable environments in space makes extraterrestrial life plausible. But plausibility is not proof. Despite decades of sear...
Move over kimchi, natto is appearing in health food shops everywhere
Japan’s smelly, slimy beans are highly nutritious but you’ll need ‘nerves of steel’ to eat them
Hurricanes Beat Flyers 3-2 In Overtime With Gostisbehere Heroics
The Carolina Hurricanes survived a scare in Philadelphia, using a former Flyer's power-play goal to secure a 3-2 overtime win.
THIS WEEK: “Sick of It! Fix Health Care Now” Bus Tour Kicks Off With Stops in Maine, New Hampshire, New York, Pennsylvania, New Jersey
Rep. Maggie Goodlander (D-NH-02), PA Lt. Gov. Austin Davis Will Headline “Sick of It! Fix Health Care Now” Events in Five States Watch All Bus Tour Stops Live Here. Washington,...
The 2026 Lookout List: Health and Wellness
Are you feeling centered? This is a place where we value having aligned chakras, purposeful movement, a good gym to frequent and a good dispensary to drop into (for those that partake). For our Health and Wellness category of the Lookout List, we asked you for the best spots to drop into for yoga, mindful moments, health food and more.
Providence Opens New Rural Health Clinic in Polson
Just over a year after breaking ground on a rural health clinic in Polson, community members, donors and hospital staff gathered Sept. 30 in front of the new building just behind Providence St. Joseph Medical Center. “Over the years we’ve heard about this need over and over again,” Chief Executive for Providence Montana Krissy Petersen […]
Cybersecurity portal to fight bad guys open for business: NMFTA
The NMFTA has launched its threat portal, where targets of successful and unsuccessful cyberattacks can share their stories.
Business Roundup: Latham Aldi sets opening date, women-only gym expands into Slingerlands
Here's what's new in the Capital Region business scene.
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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