SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " NDA " 19,192 found 🔀 AI-powered Shuffle
SAHS Dance Troupe ready for ‘United in Motion’
The talented young performers of St Andrew High School (SAHS) for Girls will take centre stage on Sunday, November 15, as the school’s Parent Teacher Association (PTA), in tandem with the SAHS Dance Troupe, presents ‘United in Motion: Dance Xplosion 2026’, an evening dedicated to celebrating student talent, artistic expression, and the power of young women to make a meaningful contribution to their school community. The event will be held at the school’s Garden Theatre located at the Hope Road entrance, starting at 6 p.m.
Sports Equinox viewing guide: How to watch every NFL, MLB, NBA, NHL, WNBA game on busiest sports day of the year
The sports equinox will fall upon Monday night this year. Make sure you make arrangements to follow along.
‘End game’: Taylor Swift and Travis Kelce mocked by opponent
The Seattle Seahawks handed the Kansas City Chiefs their first loss of the season on Sunday night, and they made sure to rub it in afterward by trolling newlyweds Travis Kelce and Taylor Swift. After their 20-3 win on Sunday Night Football, the Seahawks posted a Swift-themed troll on social media, sharing a friendship bracelet…
Shapiro Brings Campaign Tour to State College
Gov. Josh Shapiro brought his campaign bus tour to State College on Sunday evening, speaking alongside local Democrats nine days before Election Day.
Kane primed to pip Yamal, Mbappe to Ballon d'Or glory
England captain Harry Kane is the favourite to win a wide open race to be crowned Ballon d'Or winner at a glitzy London ceremony on Monday, with Lamine Yamal and Kylian Mbappe also in the running to be named the world's best footballer.- 'I deserve it' - Yamal finished second to Paris Saint-Germain's Ousmane Dembele last year and the 19-year-old Barcelona superstar seems destined to be a Ballon d'Or winner one day.
Eric Bauza, the voice of Bugs Bunny and many other Looney Tunes characters, dies suddenly, family says
Voice actor Eric Bauza, who succeeded Mel Blanc in voicing lovable Looney Tunes characters like Bugs Bunny, Daffy Duck and Porky Pig, had died, his family announced Sunday night. The family issued …
How Lula beat Bolsonaro, broke records and halted the right-wing wave aligning Latin America with Trump in 20 days
Luiz Inácio Lula da Silva made history on Sunday, setting a record for Brazil and the rest of Latin America by becoming the first president to win a fourth term – and he did so days before turning 81, an age when many other leaders decide to leave politics behind.
Bears vs. Seahawks odds: Opening lines for Week 8 matchup
The Chicago Bears and the Seattle Seahawks are both coming off prime-time Week 7 wins, and they’ll face each other under the lights in Week 8 on Monday Night Football. The (5-2) Bears knocked off the New England Patriots 30 to 24 on Thursday Night Football, while the (4-3) Seahawks just won 20 to 3 […]
BUSINESS MONDAY: Spotlight on Heart & Soil Collective’s latest offering—cooking classes!
These hands-on, farm-to-table classes bring people together to cook and share a locally grown meal while learning skills and building community.
Raptors’ Kawhi Leonard to undergo testing after concerning injury update
Kawhi Leonard was missing in action on Sunday, as the Toronto Raptors lost to the Minnesota Timberwolves , 117-94, at Target Center. The Raptors fell to 2-1, while the Timberwolves improved to 3-0. Leonard was added to the injury report just an hour before tip-off. Toronto announced that the veteran forward was dealing with swelling in his left […] The post Raptors’ Kawhi Leonard to undergo testing after concerning injury update appeared first on ClutchPoints.
Anthony Scaramucci Says Vivek Ramaswamy 'Disgraced Himself' in Ohio Governor Race: 'He’s Finished Himself as a Future Candidate'
SkyBridge Capital founder Anthony Scaramucci accused Ohio gubernatorial hopeful Vivek Ramaswamy on Sunday of abandoning his core political principles to win the high-stakes race.Scaramucci’s Scathing ...
LAFC clinch Audi 2026 MLS Cup Playoffs spot
By MLSsoccer staffLAFC have qualified for the Audi 2026 MLS Cup Playoffs, clinching their spot following a 2-2 draw vs. arch-rivals LA Galaxy on Sunday.With two regular-season matches left, the Black ...
Political expert explains what Vice President JD Vance’s upcoming visit means for Kansas
Vice President JD Vance is hosting a rally in Topeka Monday.
76ers veteran briefly raises alarm with injury scare vs. Pistons
The injury hits kept coming around the NBA on Sunday evening , but the Philadelphia 76ers seemingly avoided catastrophe with veteran guard Kentavious Caldwell-Pope. The veteran guard exited the game briefly , as per Adam Aaronson of The Philly Voice, with an apparent injury. While was initially tended to by team staff and accompanied back to the […] The post 76ers veteran briefly raises alarm with injury scare vs. Pistons appeared first on ClutchPoints.
Has Taylor Moton played final NFL game with Panthers?
Carolina's veteran right guard fractured his fibula on Sunday, leaving his NFL future in doubt.
Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game
Kansas City Chiefs star Travis Kelce made waves with his appearance in Seattle before Sunday's game against the Seahawks. The post Travis Kelce’s Physical Appearance Turns Heads Before Seahawks Game appeared first on HEAVY.
Vikings Schedule MRI for Injured Running Back
The Minnesota Vikings stayed perfect on Sunday, but they may have to wait until Monday to learn the cost of the win.
Observations after shorthanded Sixers fall to 1st loss of season
The shorthanded Sixers fell to their first loss of the season on Sunday night.
What to know about China’s plenum as Xi seeks stronger Communist Party discipline
HONG KONG (AP) — China's political leaders and elites begin a four-day meeting Monday to discuss strengthening the ruling Communist Party's discipline, as Chinese President Xi Jinping pushes for great...
Player grades: LeBron James returns, but Sixers fall to Pistons
LeBron James returns, but the Philadelphia 76ers fall to the Detroit Pistons at home on Sunday night.
Stray gunfire hits business after early-morning shooting in the Tower District
A business in the Tower District was hit by stray gunfire on Sunday.Fresno Police officers responded to a reported shooting in the area of Fulton and Dennett a
Illustration shows "Cyberattack" text and PHP code
The word "Cyberattack" and PHP code are displayed on a screen in this illustration taken on October 22, 2026.
Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension
For years, Boston Celtics fans have wondered whether Jayson Tatum and Jaylen Brown were friends off the basketball court. Following Brown’s recent comments to the media, it’s become clear that even if they were, that isn’t the case anymore.On Sunday, October 25, Celtics’ head coach Joe Mazzulla was asked about Brown’s recent comments regarding Tatum […] The post Celtics’ Joe Mazzulla Addresses Growing Tatum-Brown Tension appeared first on HEAVY.
Georgia lands son of music star in notable recruitment win
Georgia football secured a notable win during its bye week Sunday. And in the process, coach Kirby Smart and company win over fans of country star Luke Bryan. That’s because his son Bo Bryan is joining the 2027 recruiting class. The three-star quarterback chose the Bulldogs officially, becoming the newest College Football Recruiting win for […] The post Georgia lands son of music star in notable recruitment win appeared first on ClutchPoints.
9th Circuit questions DOJ demand to set aside 20,000 California mail ballots
A panel of federal appellate judges on Sunday questioned the timing, constitutionality and authority of the Justice Department's demand
Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact
Los Angeles Lakers guard Luka Doncic recorded a 52-point double-double in the Lakers' 132-123 win over the Utah Jazz on Sunday. The post Luka Doncic 50-Bomb Keeps Lakers’ Perfect Start Intact appeared first on LA Sports Report.
Man completes 12,000-mile walk across America’s four corners in Lubec for mental health awareness
Kyndal Ray Edwards, a mental health coach from Jacksonville, Florida, crossed the finish line at West Quoddy Head Lighthouse in Lubec on Sunday afternoon after visiting all four corners of the contiguous United States. Along the way, he raised funds for the nonprofit Never Alone Recovery.
Jay-Z urges fans to 'question everything' during Los Angeles show
Jay-Z urged fans to "question everything" during his final 30th anniversary concert, warning them about the rise of AI and propaganda.
Vandalia Health recognized for digital health achievement
Vandalia Health earned Level 9 recognition in both acute and ambulatory care in the 2026 Digital Health Most Wired Survey.
Lions QB Jared Goff Ties NFL History Against Rival Packers
The Detroit Lions are back in action on Sunday afternoon at Ford Field against the divisional rival Green Bay Packers in a clash that will carry heavy implications for the NFC North standings. And thanks to yet another strong start from quarterback Jared Goff, he’s not only put his club in a position to pick […] The post Lions QB Jared Goff Ties NFL History Against Rival Packers appeared first on HEAVY.
How a movement of students brought down Serbia's Vučić
In just under two years the students have succeeded in tearing up 14 years of political dominance under Aleksandar Vučić.
Serbia's student movement: How and why students brought down Vučić
In just under two years the students have succeeded in tearing up 14 years of political dominance under Aleksandar Vučić.
JESPY Trivia Friendraiser
Put your trivia skills to the test for a great cause! Join JESPY for a fun-filled Trivia Night on Sunday, November 8, 2026, from 5–8 p.m. at Avenue Pub in Maplewood.Gather your friends, enjoy some...
APTOPIX Brazil Election
Supporters of President Luiz Inacio Lula da Silva celebrate after he won the presidential runoff in Rio de Janeiro, Sunday, Oct. 25, 2026. (AP Photo/Lucas Landau)
Rams Return to Winning Ways With Statement Win Over Raiders
The Los Angeles Rams beat the Las Vegas Raiders, 35-21, on Sunday, winning a game for the first time since Week 4. The post Rams Return to Winning Ways With Statement Win Over Raiders appeared first on LA Sports Report.
Fresno police investigate shooting at Airbnb rental in Tower District
The Fresno Police Department is investigating a shooting that occurred early Sunday morning in a Tower District neighborhood.
2026 KlarText Prize for Science Communication: Klaus Tschira Foundation Honors Seven Researchers
What exactly did you do in your doctoral dissertation? The Klaus Tschira Foundation honors the most compelling answers to this question with the KlarText Prize for Science Communication. On Octobe ...
"Tomb Raider: Legacy of Atlantis" 30th Anniversary Trailer
A new trailer is out for “Tomb Raider: Legacy of Atlantis,” the reimagining of the original 1996 first “Tomb Raider” game. Created in Unreal Engine 5, it offers fresh visuals, skill trees, and an expanded Atlantis story that will tie in the various eras of Lara Croft together. As Lara, harness your wits and athleticism […]
Australian politicians pay tribute to wounded lawmaker
Australia's prime minister and fellow parliamentarians led sombre tributes Monday to "beacon of decency" and colleague Helen Haines, who remains in hospital after being struck by a car outside her off...
Vucic Concedes Electoral Defeat, Setting Stage For New Era Of Serbian Politics, Relations With West
Aleksandar Vucic, Serbia's former president and dominant political figure for more than a decade, conceded defeat to the student-led protest movement in the country's parliamentary elections, potentially ushering in a new era of politics more closely aligned with Europe and away from the Kremlin.
The Dominant Buccaneers' Offensive Line Everyone Expected Finally Showed Up
The Bucs dominated the Carolina Panthers on Sunday, and the offensive line played its best game of the season.
Kids say ‘trick-or-treat’ at downtown businesses
SIOUX FALLS, S.D. (KELO) — Kids of all ages walked up and down Phillips Avenue Sunday afternoon dressed up in their Halloween costumes. Some of those costumes featured characters from movies …
Iowa family finds strength beyond the gym after cancer diagnosis
URBANDALE, Iowa (KCCI) -- Azariah Townsend can barely reach the pull-up bar in his family’s home gym in Urbandale, but he already knows strength is not measured by height.
Dunwoody to discuss adding two entertainment districts
The Dunwoody City Council will discuss adding two new entertainment districts – Georgetown and Jett Ferry – at its meeting on Monday, Oct. 26.
Families celebrate Halloween with a side of science at Nature Museum
The Peggy Notebaert Nature Museum invited families to its annual BOO-seum Bash Sunday, with animal encounters, hands-on activities and plenty of Halloween fun.
Stephen Curry set to return Monday for struggling Warriors
Stephen Curry set to return Monday for struggling Warriors
Judges skeptical of Trump administration effort for force California to set aside mail ballots
A three-judge US Circuit Court of Appeals panel expressed significant skepticism Sunday over the Justice Department’s desire to inject itself into California’s midterm vote-counting process by forcing election officials to set aside the votes of suspected noncitizens who have been issued mail ballots.
Sunday Sports: Section 3 football matchups announced and more
Here’s a recap of your North Country sports this Sunday.
TMSM Weekly Recap: Star Wars Super Bowl, Cap Lifts Thor's Hammer, Halloweentown 5 and More
Missed anything? Here are the biggest Disney stories from October 18 to 24, from Star Wars Funday Football and Avengers: Doomsday to Halloweentown 5 and Gideon's new trading cards.
Pistons' Ausar Thompson ruled out against Sixers
The Pistons will be without Ausar Thompson on Sunday night for their match against Philadelphia.
ATM stolen from business in Brighton Park, Chicago police say
Chicago police are looking for the people who stole an ATM from a convenience store Sunday morning on the city's Southwest Side.
Absent Vinícius Jr. ‘laughs’ at Barcelona after Real Madrid victory
Real Madrid star Vinícius Jr. has on Sunday evening taken to social media, to issue his response to his side’s victory over arch rivals Barcelona.José Mourinho’s troops made the trip to the Spo...
Raptors to miss Kawhi Leonard on Sunday night
The Raptors will be without a key piece of their lineup on Sunday night.
Serbia’s Vucic concedes defeat in seismic political shift
The long-serving strongman leader of Serbia, Aleksandar Vucic, has conceded defeat in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government
49ers' First Loss Makes It Clear: Their Toughest Opponent Is Their Health
The 49ers picked up their first loss of the season on Sunday, but it wasn't what the Falcons did that caused them to stumble.
Matthew Stafford breaks Rams franchise record for touchdown passes
LAS VEGAS (AP) — Matthew Stafford added another milestone to his NFL career on Sunday, throwing his 155th touchdown pass for the Los Angeles Rams to break the franchise record.Stafford surpassed Roman Gabriel, who threw 154 TD passes for the Rams from 1962-72.
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift
The long-serving strongman leader of Serbia, Aleksandar Vucic, conceded defeat on Sunday in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government.
Aleksandar Vucic concedes defeat in Serbia's parliamentary election, marking political shift
Aleksandar Vucic, who denounced the oppositional student movement as a foreign-led attempt to unseat him, led with virtually absolute power for 14 years.
Aleksandar Vucic: Serbia's veteran ruler felled by student-led movement
The dominant force in Serbian politics for over 14 years, Aleksandar Vucic, who conceded defeat in a snap parliamentary poll on Sunday, rose from the wreckage of strongman Slobodan Milosevic's cabinet...
Is an Academy of Natural Sciences divorce coming?
Hearings for the museum are coming Monday. Will it make a difference?
Sharpen memory and fight brain fog with simple 60-second trick from a neurologist
Dr. Rhonda Voskuhl explains why crosswords and sudoku miss the mark for brain fog and which timed word games actually target verbal memory loss.
Photo: Jude Bellingham’s head-turning new boots for Barcelona showdown
Real Madrid star Jude Bellingham has on Sunday evening provided a look at the head-turning footwear that he is set to make use of in El Clásico.The latest edition of Spanish football’s most bitter ...
Mid-Hudson Valley business calendar for the week of Oct. 26, 2026
Mid-Hudson Valley business calendar
Bayern beat Freiburg to reclaim top spot after Kompany illness
Bayern Munich reclaimed top spot in the Bundesliga with a 3-1 win at Freiburg on Sunday, days after coach Vincent Kompany was hospitalised when he collapsed at training.With coach Kompany still in hospital after collapsing on Friday, Englishman Danks was in the dugout.
Supercurrent enables the reading of quantum information without destroying it
One of the fundamental challenges of quantum computing is obtaining information from a quantum bit, or qubit. Unlike a conventional bit, which can be read repeatedly without altering its content, direct ...
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center
The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.
Asher Grunis steps down from leading Submarine Affair commission due to health concerns
Supreme Court President Isaac Amit appointed retired Supreme Court justice Zvi Zylbertal to replace Grunis and lead the commission on Sunday.
Three Premier League talking points
Michael Carrick was pushed to the brink of the sack by Manchester United's latest debacle on Sunday.AFP Sport looks at three talking points from the weekend's action: Walls closing in on Carrick Michael Carrick's future as Manchester United boss was already hanging by a thread before Bournemouth inflicted what is likely to be a brutal last act for the former England midfielder at Old Trafford.
Defender turns striker and scores in Bayern win
Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...
Nigeria widens hunt for possible Ebola cases
Nigeria has widened a hunt for potential Ebola cases, with an additional nine contacts traced, health authorities said Sunday.The initial 44 contacts were health care workers, while the additional nin...
Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS
A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine
Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
Sunday Open Thread
There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1
DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1
NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...
Steelers beat Saints to win first NFL game in Paris
The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.
NFL Week 7 Sunday afternoon open thread
Join us at Buffalo Rumblings as we chat all things NFL Week 7 LIVE with like-minded folks in Bills Mafia
Jay Glazer Shares Jalen Hurts Health Update, NFL And NFLPA Joint Investigation
On "FOX NFL Sunday," Jay Glazer shared the latest on Jalen Hurts' health and said that the NFL and NFLPA are doing a joint investigation.
Blanche says Trump isn’t trying to meddle with Alaska election results by suing over Senate race
WASHINGTON (AP) — Attorney General Todd Blanche on Sunday defended the Trump administration's lawsuit to block certification of Alaska's Senate results if Repub
Sunday Puzzle: BRB
NPR's Ayesha Rascoe plays the puzzle along with Weekend Edition Puzzlemaster Will Shortz and WUOT listener Jordan Bogdan of Oak Ridge, Tennessee.
Health care shakes up the Iowa election
If Democrats flip Congress, health care could find its way to the top of their 2027 agenda.
Photographer and medical professionals connect science and art during panel discussion
In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns
The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]
Political cartoons for October 25
Sunday's political cartoons include increasing costs, the White House briefing room, and more
Game Time Thread: Juventus vs. Lecce
MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals
Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.
Google's next TV gadget may do much more than stream
A reported hardware overhaul could bring Gemini further into the living room.
On Christ the King and the idolatry of politics
Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K
13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.