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Mission Historical Museum to Celebrate Día de los Muertos
The Mission Historical Museum will invite the community to celebrate culture, remembrance and tradition during its annual Día de los Muertos Folklife Festival on Saturday, Oct. 24, 2026.
McInnes on 'fire and ice', derby first & 'godsend' Miovski
Rangers manager Derek McInnes has been speaking to the media before the League Cup quarter-final against Celtic on Sunday at Ibrox. The Ibrox boss emphasised the importance of striking the first blow against a good Celtic team to deliver the chance to "be relevant domestically again in terms of winning trophies". McInnes stressed the need for discipline alongside being competitive and aggressive, adding a "bit of fire and ice at the right times can help matters".
Penn State Freshman Josiah Zayas Standing Out
Through all the changes Penn State's roster has seen over the last nine months, one position group has remained relatively unchanged. The Nittany Lions retained starting cornerbacks Daryus Dixson, Audavion Collins and Zion Tracy. The three defensive backs made a combined 24 starts a season ago and were primed to start even more games this …
Walmart Reinvents the Store for a Faster Digital Future
Walmart President and CEO John Furner and Executive Vice President and Chief Financial Officer John David Rainey pointed to value, faster delivery and digital growth as key factors behind the retailer’s second-quarter performance in a video Furner posted on his personal LinkedIn account following the release of Walmart’s Q2 FY27 financial results.
Seahawks beat Patriots 13-10 in Super Bowl rematch
Backup quarterback Drew Lock led two late scoring drives and the Seattle Seahawks intercepted Drake Maye three times in the fourth quarter to overcome an early injury to starter Sam Darnold and beat the New England Patriots 13-10 in a Super Bowl rematch.
Dortmund's Karetsas out of weekend game but Schlotterbeck may return
Borussia Dortmund's Konstantinos Karetsas will miss Saturday's Bundesliga home game with Paderborn but is not expected to be out long-term. The 18-year-old Greek, who has made a strong start to his Dortmund career after moving in the transfer window from Genk, was substituted in the first half of Dortmund's 3-2 Champions League win against Villarreal on Tuesday due to circulatory problems.
Dortmund's Schlotterbeck and Bensebaini "ready to play" against Paderborn
Borussia Dortmund can once again rely on both Nico Schlotterbeck and Ramy Bensebaini for Saturday's game against SC Paderborn.“Ramy and Schlotti have participated fully in the recent training sessio...
Texas A&M Faces Arizona State Test After Dominant Season Opener
Texas A&M meets Arizona State in a major Week 2 test as Marcel Reed and the Aggies face red-hot quarterback Cutter Boley and the explosive Sun Devils.
Former Vol quarterback debuts as Seattle's defensive quality control
Former Tennessee quarterback begins his first season as a defensive quality control coach for Seattle.
City's last five meetings with Manchester United
Ahead of Sunday’s eagerly awaited Manchester derby clash away to Manchester United we look back to our most recent games against our nearest rivals. Men's Team Analysing Manchester United ahead of S...
Reports: Deshaun Watson cited for speeding last month, issues plea
Cleveland Browns starting quarterback Deshaun Watson was reportedly cited for speeding in Ohio last month.
Thursday, more Liberta, Sula and Champions League, see agenda 📲
Today’s Highlights 🔥Champions League13:45 – Fenerbahçe vs Roma – TNT, HBO Max, TNT Sports YouTube13:45 – PSV Eindhoven vs Shakhtar Donetsk – Space, HBO Max16:00 – Bayern Munich vs Bod�...
‘Horrible Game From Drake (Maye), Disgusting’ — Barstool Sports’ Dave Portnoy Rips Patriots QB After Meek Week 1 Loss to Seahawks
The New England Patriots opened the season with a result that has quickly turned optimism into frustration. A promising 10-0 start against the Seattle Seahawks on Wednesday night disappeared as the Patriots struggled to finish drives and protect their lead against a team that lost its quarterback on the opening drive.
Tottenham's updated Richarlison January plan revealed
Richarlison in action with Roberto De Zerbi walking into stadium right inset
Fenerbahçe vs AS Roma – Match preview and team news
AS Roma and Fenerbahçe return to the UEFA Champions League after a long wait and will now face each other in their opening UCL fixture this season on Thursday at the Chobani Stadyumu in Istanbul.Fene...
AS Roma XI vs Fenerbahçe – Predicted lineup and team news
AS Roma and Fenerbahçe are finally back in the UEFA Champions League after a lengthy absence, and they will meet in their first UCL game of the season on Thursday at Istanbul’s Chobani Stadyumu.AS ...
Manchester United vs Sabah – Match preview and team news
Manchester United’s long-awaited return to the Champions League begins at Old Trafford on Thursday, when they host Azerbaijani debutants Sabah in a first competitive meeting between the two clubs.Mi...
Seahawks news: Drew Lock speaks up on unexpected night amid Sam Darnold injury
The Seattle Seahawks raised their Super Bowl LX banner on Wednesday night. Then, they took on the New England Patriots in a rematch of the big game. Quarterback Sam Darnold exited with an injury in this game. But backup Drew Lock was ready to answer the challenge. Lock entered the game in the first quarter, and he went to work. He finished the game […] The post Seahawks news: Drew Lock speaks up on unexpected night amid Sam Darnold injury appeared first on ClutchPoints.
Buccaneers Get Huge Support From Insider Poll About NFC South
The Tampa Bay Buccaneers have a lot of expectations to have a good NFL season with a strong roster. Quarterback Baker Mayfield will attempt to lead Tampa Bay to contention for the Super Bowl. One insider poll from Yahoo led to a group of insiders voting on the biggest topics entering the NFL season. Eight […] The post Buccaneers Get Huge Support From Insider Poll About NFC South appeared first on HEAVY.
Seahawks’ Mike Macdonald Issues Strong Words Amid Sam Darnold Injury
The Seattle Seahawks took a major hit early in the game against the New England Patriots. Starting quarterback Sam Darnold left the game due to a hip injury; he was initially ruled questionable, but the team later ruled him out. Heading into halftime, Seahawks head coach Mike Macdonald shared a quick message on how the […] The post Seahawks’ Mike Macdonald Issues Strong Words Amid Sam Darnold Injury appeared first on HEAVY.
Report: Browns QB Deshaun Watson cited for speeding in August
Browns quarterback Deshaun Watson was cited for speeding by the Ohio State Highway Patrol on Aug. 26, according to a Fox 8 report.
Saints news: Tyler Shough notches 'biggest accomplishment' before 2nd year
The New Orleans Saints have a lot of reason for optimism coming into the 2026 season, and a lot of that has to do with second-year quarterback Tyler Shough . Shough didn’t begin his rookie season as the QB1 in New Orleans, but he took over for Spencer Rattler midseason and gave Saints fans hope that he might be the quarterback of the future. Now, […] The post Saints news: Tyler Shough notches 'biggest accomplishment' before 2nd year appeared first on ClutchPoints.
Packers' QB Jordan Love Shares Goals for 2026 Season
Green Bay Packers quarterback Jordan Love opened up about his goals for the 2026 season.
Soul City Sirens offers beginner roller derby boot camp
AUGUSTA, Ga. (WJBF)- For those of you looking to get into roller skating, get your skates ready because there’s a Soul City Sirens bootcamp coming your way. The Sirens are Augusta’s only women’s flat track roller derby league, an active not-for-profit organization in Augusta. This six-week bootcamp is designed specifically for beginners, so you don’t […]
Notre Dame football cornerback DJ McKinney reflects on 'amazing' debut
Notre Dame football's DJ McKinney ended up playing 43 defensive snaps in the opener, highlighted by a pick-six.
Seahawks QB Sam Darnold Departs Season-Opener vs. Patriots After First Drive
If the Seattle Seahawks are going to beat the New England Patriots again, then they might have to do it without their starting quarterback.
6-Foot-2 Former Broncos Cornerback Back Signs With Bears
Former Denver Broncos cornerback Keidron Smith has found a new NFL home in the NFC with a team garnering Super Bowl projections. The post 6-Foot-2 Former Broncos Cornerback Back Signs With Bears appeared first on HEAVY.
Athlete of the Week: Crane junior Hudson Willis
CRANE, Texas (KMID/KPEJ) – We’re already through two weeks of the high school football season, and the Crane Golden Cranes are off to a perfect start. After opening the season with a win over Compass, Crane defeated Kermit 40-34, improving to 2-0 on the season, and leading the way was junior quarterback Hudson Willis, our […]
How Far Can Fabrinet Stock Fall While Its Business Accelerates?
Fabrinet (FN) trades near $416, about 44% below the high it set in the past year. Its own results point the other way: fiscal 2026 ended in June with revenue up 36%, and management has guided the fiscal first quarter of 2027 to 43% growth at the midpoint.
Joe Burrow's press conference before season-opener vs. Tampa Bay
Bengals quarterback Joe Burrow talked to the press on Wednesday, Sept. 9 before the season-opener against the Tampa Bay Buccaneers.
'They showed their commitment to the club'
West Bromwich Albion manager James Morrison is delighted with his side's defensive work after playing for nearly an hour with 10 men in the win at Derby.
Arsenal edge Napoli as Odegaard continues fine start to season
Martin Odegaard maintained his superb start to the campaign as Arsenal opened their Champions League journey with a hard-fought 1-0 victory over Napoli.The Gunners dominated much of the contest but we...
Writer makes bold prediction regarding Vikings QB Kyler Murray
Kyler Murray could be a top-12 quarterback in a key metric this season.
Former STC Dual Credit Student Joins Computer Science Faculty
Texas Border Business By Joey Gomez McALLEN, Texas – South Texas College’s newest Computer Information Technologies (CIT) faculty member, Ramiro Santos believes he has come full circle. Not long ago, Santos was a dual credit student from PSJA Southwest Early College High School, who turned to STC faculty for guidance as he discovered a passion for […]
Deshaun Watson Sends Clear Message on Jaguars Ahead of Opener
Cleveland Browns quarterback Deshaun Watson has history with the Jacksonville Jaguars. The post Deshaun Watson Sends Clear Message on Jaguars Ahead of Opener appeared first on HEAVY.
Border Operations Yield 247 Additional Cases in Early September
Another 247 people have been charged, including 232 illegal aliens, in 239 cases involving immigration and border security-related crimes from Aug. 28-Sept. 3.
C. diff coordinates threat response to survive in gut
Researchers at Vanderbilt Health have discovered a unique system C. diff uses to simultaneously sense and respond to two different threats.
Can Meister emulate Agyemang at Derby?
Derby County talent acquisition lead Leigh Bromby says the club signed Henrik Meister this summer with big expectations and an eye on the future.
An onslaught of midterm polling is coming. Here’s how to sort through it
If read carefully, high-quality polls can still tell you a lot about how this year’s midterms are shaping up – and keeping a few simple questions in mind can help you sort through the overwhelming and sometimes overblown deluge of data.
Texas and Nuevo León Advance Strategic Economic Partnership
Texas and Nuevo León officials and business leaders are moving to strengthen long-term economic cooperation following two days of meetings in Austin focused on investment, innovation, workforce development and strategic planning.
Steelers holding leverage in Joey Porter Jr. contract talks
The Pittsburgh Steelers maintain crucial franchise tag options as negotiations with cornerback Joey Porter Jr. enter a critical pre-season stretch.
INSIDE CLIMATE NEWS: NOAA Fisheries takes a ‘sharp turn away from science’
The agency’s focus on commercial interests threatens fisheries science and over one million miles of protected marine habitats. By Johnny Sturgeon, Inside Climate News This article originally appeared on Inside Climate News, a nonprofit, non-partisan news organization that covers climate, energy and the environment. Sign up for their newsletter here. In July, the Trump administration relegated endangered leatherback turtles, sea lions and whales to mere collateral damage in its race to profit from the oceans. Now, fisheries science is in […]
Herbert Simon Family Foundation to present experimental creative showcase with ‘Risky Business’
A new “experimental creative showcase” is coming to the Contemporary Art Museum of Indianapolis (CAMi) this fall thanks to the Herbert Simon Family Foundation.
The Rwandan eyeing Champions League history against Man Utd
Rwanda forward Joy-Lance Mickels has helped Azerbaijan's Sabah reach the Champions League proper on their competition debut, and is now looking to down the team he supports.
BUSINESS SPOTLIGHT: Visit SEWing-FUN
The following is an interview with Nancy E. Easterbrooks, owner of SEWing-FUN at 24 Bessom St. #1, conducted by Discover Marblehead. SEWing-FUN is a creative local gem bringing the joy of sewing to Marblehead. Led by a passionate sewing coach, it’s all about learning, creating and having fun — whether you’re stitching your first project
Ranking Every NFC West Quarterback From Worst to Best
The reigning MVP Matthew Stafford and reigning Super Bowl champion Sam Darnold lead the QB-heavy division.
Fantasy Football Week 1 2026 Start ‘Em Sit ‘Em: Quarterback
Week 1 is finally here, and with it comes the annual gut-check every fantasy manager dreads: trusting your gut on a quarterback you drafted or trusting the matchup staring you in the face right now. The names that dominated August mock drafts don’t always match up with the defenses they’re about to face, and a handful of under-the-radar arms are […] The post Fantasy Football Week 1 2026 Start ‘Em Sit ‘Em: Quarterback appeared first on ClutchPoints.
Browns cornerback Denzel Ward joins Guardians’ ownership group
The Macedonia native is the second prominent athlete from Northeast Ohio to buy a stake in the Guardians this year, joining Travis Kelce.
Goodwin sells part of defence business for £1.1bn to US firm
The group strikes a deal with Cerberus, a firm set up by US defence official Stephen Feinberg.
Is Senesi a long-term starter for Spurs?
"He's comfortable playing in a possession-based team, reads the game very well and has the personality to thrive in a demanding environment," Roberto de Zerbi said on Marco Senesi after Tottenham signed the defender in June. Senesi was a big get for Spurs. It was expected Senesi would slot straight into De Zerbi's starting XI - and he did for the Premier League opener away at Brentford.
Titans Unofficial Depth Chart Ahead of Season Opener vs. Jets
Cam Ward secures the starting quarterback role while Cedric Gray overcomes a concussion scare to lead the defense as Tennessee finalizes its lineup for the Week 1 clash.
Scientists in Switzerland made a sponge from cheesemaking waste that captures gold from discarded electronics — after dissolving metal parts from 20 old computer motherboards, they recovered enough to melt into a 22-carat gold nugget
A Swiss lab transformed dairy waste into a gold-recovery tool, extracting precious metal from e-waste that most recyclers leave behind.
Serbia dissolves parliament as snap elections called
Serbia will head to the polls in late October after President Aleksandar Vucic dissolved parliament following growing pressure from protesters demanding political change. However, Vucic plans to stand as a PM candidate.
Jaguars CB Montaric Brown Predicted to Regress this Season
After a breakout campaign in 2025, one analyst is still not convinced that Montaric Brown is an above-average starting cornerback for Jacksonville.
Is Patriots CB Christian Gonzalez playing today?
What is Patriots cornerback Christian Gonzalez's game status for Wednesday's season opener against the Seahawks?
Serbia to hold October snap election
The ruling SNS party named President Aleksandar Vučić as its candidate for prime minister
8 events in Lancaster County this weekend, from a whoopie pie festival to an herb fest
There's a lively weekend on tap for Lancaster County.
Cowboys Issued Strong Josh Sweat Take Amid 49ers Speculation
The San Francisco 49ers need more of a running mate to go along with Nick Bosa. Moreover, the Niners shouldn’t put all their hopes of sacking the quarterback on Bosa, given his injury history; he’s dealt with tendinitis during training camp and the preseason. As a result, the Niners could use the first two months […] The post Cowboys Issued Strong Josh Sweat Take Amid 49ers Speculation appeared first on HEAVY.
Eagles' Tanner McKee Continues Being Top Trade Candidate
Philadelphia Eagles quarterback Tanner McKee continues to be named a top NFL trade candidate.
Baker Mayfield Agrees to Extension After ‘Disrespectful’ Buccaneers Offer
Baker Mayfield walked off the field in Jacksonville last month after a scoreless preseason finale, hardly the tune-up a quarterback wants heading into a contract year. Weeks earlier, the Tampa Bay Buccaneers passer had called the team’s opening offer ‘disrespectful’ and shut down extension talks completely. That standoff loomed over training camp all summer. Now, […] The post Baker Mayfield Agrees to Extension After ‘Disrespectful’ Buccaneers Offer appeared first on Gridiron Heroics.
Vikings Projected to Likely Strike NFL QB Deal Before Deadline
Bleacher Report's Alex Kay named Minnesota Vikings quarterback J.J. McCarthy the most likely signal-caller to be traded during the 2026 NFL season. The post Vikings Projected to Likely Strike NFL QB Deal Before Deadline appeared first on HEAVY.
Baylor finds confidence and belief despite loss to Auburn
WACO, Texas (FOX 44) — Baylor may have lost the battle on the scoreboard Saturday, but the Bears believe they gained something just as important in Atlanta: confidence. Despite a loss to Auburn, Baylor players said the game showed the team’s growing chemistry, physicality and belief heading into the rest of the season. Fifth-year cornerback […]
Illinois Quarterback Katin Houser Leads NCAA in This Passing Stat
The Fighting Illini passer dazzled in Week 1 with his new team.
Bengals' Dalton Risner Admits Causing Joe Burrow's Injury in 2025
Haunted by a critical lapse that sidelined his quarterback, the veteran lineman reveals how owning his mistake fueled a career resurgence and strengthened Cincinnati's front five.
Baker Mayfield Cashes In Ahead of Browns Reunion
Former Cleveland Browns quarterback Baker Mayfield just cashed in with a massive payday. The post Baker Mayfield Cashes In Ahead of Browns Reunion appeared first on HEAVY.
Meet the Lehigh Valley's newest political bosses
Northampton County Democratic Chair Baron Vanderburg and Lehigh County Republican Committee Chair George Rivera want to change the course of politics in the Lehigh Valley.
Bills Announce Exciting Josh Allen News Before Season Opener
The Buffalo Bills announced that quarterback Josh Allen is among the six players picked as captains for the 2026 season. The post Bills Announce Exciting Josh Allen News Before Season Opener appeared first on HEAVY.
Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk
The Kansas City Chiefs fans are still not completely certain whether Patrick Mahomes will be starting in the season’s opening Week 1 game. The team suffered heavily last season when the quarterback suffered an ACL injury that has kept him out for a long time. He has missed the entire offseason, including the preseason games. […] The post Severe Warning Issued Over Technique Putting Patrick Mahomes at Risk appeared first on Gridiron Heroics.
Andy Reid Officially Confirms Patrick Mahomes’ Week 1 Status
It has seemed like a forgone conclusion that Patrick Mahomes will start at quarterback for the Kansas City Chiefs Week 1, but it has not been set it stone. That changed on Tuesday when coach Andy Reid spoke to the media and officially confirmed that Mahomes will play Week 1 against the Denver Broncos on […] The post Andy Reid Officially Confirms Patrick Mahomes’ Week 1 Status appeared first on HEAVY.
TRUE Community Credit Union Highlights Business Services
Airdate: September 8th, 2026 TRUE Community Credit Union Highlights Business ServicesSeptember 8, 2026Purple Rose Theatre to Present World Premiere by Devin ScillianSeptember 8, 2026Dr. Grant Brown on Autumn Vaccine RecommendationsSeptember 8, 2026Silver Maples of Chelsea Hosting Jackson Art Association Member ShowcaseSeptember 8, 2026Jackson County Genealogical Society Hosting Cemetery TourSeptember 8, 2026Otterbein SeniorLife Jackson Dedication &…
Buffalo Bills name 6 captains for 2026 NFL season
Who joins quarterback Josh Allen and linebacker Terrell Bernard as an official captain for the Buffalo Bills in 2026?
Meta introduces Muse, a personal AI agent that can send emails, book travel
Meta on Tuesday unveiled personal AI agent Muse that can autonomously send emails, book travel on a person's behalf, sell a car and make payments.
DHR Health and RGV College Honor First-of-Its-Kind Nurse Apprenticeship Class
DHR Health and RGV College came together to celebrate the fifth co-hort of 10 graduates who completed the Registered Nurse Apprenticeship program.
Kansas State Adds Former Temple CB Ben Osueke
Temple Owls cornerback Ben Osueke was granted an extra year of eligibility and has decided to play for the Kansas State Wildcats
Dan Campbell Gives Kerby Joseph Update Ahead of Week 1
Kerby Joseph has returned to the Detroit Lions facility as he continues recovering from the knee injury that ended his 2025 season.
Deluzio Says He 'Might' Challenge Fetterman For Senate Seat
According to Merriam-Webster, the word "Might" functions primarily as a modal verb indicating possibility or uncertainty. In politics, it provides an open door to speculation for any and all political pundits. Rep. Chris Deluzio (D-17) propped that door ajar on Sunday when he indicated he 'might' mount a primary challenge…
Celebrating 19 Years of Impact from One Iconic Desk
For nearly two decades, Administrative Assistant Carolina Rodriguez has been one of the first faces people see and one they remember at South Texas College’s (STC) Mid-Valley Campus. Long before titles or job descriptions, she became something harder to define but easy to feel: a constant presence, a listening ear and the heart of the campus.
Deonte Banks' ex-coach: 'Everbody's gonna see' why Giants drafted him
Henry Baker, the former coach of New York Giants CB Deonte Banks, believes everyone is about to see why he was a first-round pick.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Patriots make Christian Gonzalez the NFL's highest-paid cornerback, AP sources say
Christian Gonzalez has agreed to a four-year, $135 million contract with the New England Patriots that makes him the highest-paid cornerback in NFL history, two people with knowledge of the deal told The Associated Press on Tuesday. One of the people said Gonzalez is getting $102 million guaranteed. Gonzalez surpassed Devon Witherspoon's new contract from the Seattle Seahawks.
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
Andrew Davis Returns to Mission for Inaugural Small Business Expo
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Contract grade for Christian Gonzalez's $135 million extension with Patriots
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Vuskovic 'a massive talent'
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