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Small Business Central to American Prosperity Celebration
House Small Business Committee celebrates small businesses as key to American prosperity ahead of nation's 250th anniversary. Learn why Main Street matters.
Kelsey Grammer says he’s considering a run for political office
Grammer, who met with Trump on Thursday, has hinted that his political aspirations may manifest “in some way” in the coming years.
Buckingham Palace without the king? Charles reveals plans for landmark's future
Buckingham Palace is having a monumental glow up, but King Charles III and Queen Camilla still don't want to live there.
Business owner in South Carolina arrested, officials say
A business owner in South Carolina was arrested Friday and is accused of operating without a retail license, according to the South Carolina Department of Revenue.
Apple’s Touch MacBook to Use M5 Pro and Max Chips, With M7 Models to Follow
Apple Inc.’s first-ever touch-screen laptop will rely on the company’s current high-end M5 chips, rather than next-generation silicon, though the company is working on a follow-up model with future M7 processors.
Who plays in the World Cup today, June 26?
Here's your daily rundown on Philadelphia's Fan Festival hours and entertainment.
Vance Downplays Watergate and Compares Himself to Nixon
The vice president said that the scandal that ended Richard Nixon’s presidency would be “like a 12-hour news story” if it happened today and that the “deep state” had taken down Nixon.
Medical Debt Bills Advance, House Hears Behavioral Health Testimony
Several healthcare-related bills advanced in the Michigan Legislature during the week of June 22, including legislation addressing medical debt collections and behavioral health screenings.
Best Prime Day deals 2026: Amazon's summer sale ends today
We're into the final hours of Prime Day. Don't miss out on our deal highlights from our top-tested picks.
Remigration: a growing far-right movement
Once a fringe position, calls for mass deportation are spreading throughout Europe and entering mainstream politics
MOMENT OF SCIENCE: How music can be interpreted differently
Music is a universal language, although how we perceive it can change from person to person.
PENN Entertainment (PENN) Just Overtook the 20-Day Moving Average
Should investors be excited or worried when a stock crosses above the 20-day simple moving average?
Why Do Deadly Viruses Spare Mosquitoes? Science Has an Answer
Mosquitoes carry some of the world's deadliest viruses, biting victim after victim for their entire lives without ever getting sick themselves. Scientists have long suspected a biological explanation,...
Whole Hog Politics: It was voters, not Senate Republicans, who forced Trump’s hand on Iran
The early returns are in, and we can pretty safely say that Americans like the peace with Iran but strongly dislike the war that it ended. The truce is shaky, with hour-by-hour challenges that seem...
Newsom urges a national 'billionaires' tax' while fighting one in California
California Gov. Gavin Newsom is calling for a national “billionaires' tax” and suggests the U.S. government should own a stake in AI companies.
NASA's canceled Artemis hardware contracts reached $5.9 billion, audit finds
NASA was on track to pay nearly half a billion dollars for a stage adapter. A stage adapter should not cost half a billion dollars.
Trump election bill fight brings House business to a halt
A Republican revolt over President Donald Trump's election overhaul bill has thrown the House into disarray.
Trump election bill fight brings House business to a halt
A Republican revolt over President Donald Trump's election overhaul bill has thrown the House into disarray.
Warren Buffett Bought A Business For $1.7B ‘Over The Phone Without Ever Meeting The People There’ Using The ‘Most Valuable Skill’ He Learned
Buying a company for $1.7 billion without meeting management sounds like the kind of decision that would keep lawyers busy for months. Warren Buffett did it over the phone. Speaking at the University of Nebraska-Lincoln in 2003, Berkshire Hathaway Chair...
5 free agent cornerback options for the Detroit Lions
Five cornerback additions the Detroit Lions should consider after Terrion Arnold’s arrest.
Scientists stunned by signs of ancient life in a place no one expected
Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.
Chairman Guthrie, Health Vice Chair Harshbarger, Congresswoman Miller-Meeks Lead Site Visit to Iowa Hospitals to Highlight Benefits of the Rural Health Transformation Program
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Should “Success” in Science Be Measured Differently?
Publication volumes are one of the main ways that success is measured for researchers today. From mentorship to real-world impact, scientists argue that “publish or perish” pressures overlook many of the contributions that drive discovery forward.
Should I Start A Business From Passion Or With The Intention To Sell?
Sara Blakely did not set out to build a billion-dollar company. She just wanted better underwear.
Trump Mobile Takes The T1 Phone Reservation Holders For A Ride, Opens Sales To The Public Without Clearing The Backlog
Those who paid Trump Mobile a $100 deposit to gain early access to the T1 Phone suddenly find themselves at the back of the proverbial queue.
Bayer wins in US court, but at what cost to public health?
A landmark US Supreme Court ruling protects Bayer from thousands of lawsuits linked to its Roundup weedkiller. Plaintiffs alleged the German agrochemical giant failed to warn users about potential cancer risks.
After Supreme Court’s TPS decision, more than a million immigrants face scramble to stay in US
Until Thursday, hundreds of thousands of Haitians were legally living and working in the United States, along with thousands of Syrians. Now, they’re in legal limbo.
In governor's race, voters face stark choice on immigrant healthcare
California’s next governor will face tough decisions on a highly controversial piece of healthcare policy: what to do about health coverage for the more than 1.4 million low-income residents without legal status.
Federal AI security center measure advanced by House Science
A measure that would put into law a key federal office focused on artificial intelligence advanced Thursday out of the House Science, Space and Technology Committee, as part of a slate of AI-focused and data center bills. The committee advanced the bills on a bipartisan basis, but put off potential changes regarding funding levels for […]
Democrats’ real plan to control Congress again
New York’s socialist insurgents are getting the headlines. But in swing House districts, the establishment has been getting its way.
NTT DATA | Transforming Data Into Exceptional Fan Experience
We worked with Penske Automotive Group to create a mobile application to amplify the fan experience and make the iconic Indianapolis Motor Speedway a smart venue through NTT Smart Solutions.
The nation’s cartoonists on the week in politics
Every week political cartoonists throughout the country and across the political spectrum apply their ink-stained skills to capture the foibles, memes, hypocrisies and other head-slapping events in the world of politics. The fruits of these labors are hundreds of cartoons that entertain and enrage readers of all political stripes. Here's an offering of the best of this week's crop, picked fresh off the Toonosphere. Edited by Matt Wuerker.
Freedom Con: Thousands of Men Gather for Christianity and Feats of Strength
Thousands of men and boys gathered in central Washington for masculinity, Christianity and right-wing politics.
Sweden: European Social Rights Committee calls for an end to Sweden’s two-tier healthcare system
Amnesty International welcomes a landmark decision by the European Committee of Social Rights finding that Sweden breached the right to health without discrimination.
World Cup brings a boost to bar and restaurant businesses across the Piedmont-Triad
Bars and taprooms across the Piedmont-Triad are extending their hours and providing the ultimate experience as the World Cup enters its second week.
Tigers host the Astros on home losing streak
The Detroit Tigers are looking to stop their three-game home slide with a victory against the Houston Astros
The heatwave hacks that will actually help to keep you cool
Should you wear wet socks to bed or point a fan out the window? Can the ‘Japanese door fan’ technique cool a baking hot car? Here’s what the science says
Former Illinois forward Ben Humrichous signs contract with Nets
Heading to Brooklyn.
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
While much of Hollywood was consumed by the streaming wars, Issa Rae was studying a different mode of entertainment thousands of miles away: microdramas. No stranger to creating a successful online s...
UFC Baku early weigh ins results
Ultimate Fighting Championship (UFC) will stage its early and official weigh ins at 9 a.m. local time for this weekend’s UFC Baku mixed martial arts (MMA) event on Paramount+. Unfortunately for stateside fight fans, Baku is eight hours ahead of Eastern Standard Time, so most of us will be asleep by the time the first […]
West Knoxville business closing as Tennessee tightens hemp regulations
The Hemp House in West Knoxville will close by July 2 as Tennessee’s new hemp regulations take effect.
Billionaire tax, affordable housing: See the measures on California's November ballot
California voters will decide on 14 statewide policy proposals come November, from the controversial billionaire tax to an $11 billion affordable housing bond.
Health concerns still loom after LAFD knocks down Boyle Heights warehouse fire
JD Vance says Nixon’s Watergate scandal would be ‘12-hour news story’ today
Vice-president declares admiration for 37th president and claims Nixon and Trump targeted by ‘deep state’ forces
Mental health as both outcome and determinant in climate adaptation
Nature Climate Change - Mental health should not be viewed solely as a passive outcome of climate adaptation. Rather, it serves as a key determinant of cognitive capacity and shapes the...
Clark | You should be supporting club sports
Club sports programs excel with a low barrier to entry, strong communities, and intense competition.
UCLA comparative literature department to offer health humanities minor in fall
UCLA will offer a minor in health humanities starting this fall. The minor, housed under the comparative literature department, is an interdisciplinary program that examines how health and medicine are shaped by literature, culture, history and social experience, according to the department’s website.
WATCH: Stephen Miller says 'America's doors are closed fully to asylum seekers' after Supreme Court rulings
The Supreme Court voted 6-3 on Thursday to allow the Trump administration to end legal protections for migrants fleeing violence and natural disaster in Haiti and Syria, exposing hundreds of thousands more people to potential deportation.
Growing sinkhole in Houston's Third Ward raising safety concerns for business owner, neighbor
A growing sinkhole behind a property on Scott Street in Houston’s Third Ward is raising concerns for a longtime business owner and her neighbor.
FEMA official who claimed he teleported to Waffle House ousted from agency, sources say
A top FEMA official who had drawn scrutiny for bizarre past remarks — including claiming he teleported to a Waffle House — has been pushed out of the agency, four sources tell CNN.
Vance, an admirer of Richard Nixon, says Watergate would be 'a 12-hour news story' today
Vice President JD Vance says the Watergate scandal that brought down President Richard Nixon would have been a blip in today’s news cycle
Golden State Valkyries employee named in Sports Business Journal's Forty under 40 list
The Golden State Valkyries have created a winning culture on and off the court. After making WNBA history last season becoming the first expansion team to reach the playoffs, the success is also extending throughout the organization.
Inside Trump’s plans for retribution and other lesser-known allegations in ‘Regime Change’
A new book from two Washington reporters reveals what took place inside the White House after President Donald Trump’s return to power.
Plaucheville business opens parking lot to Red Cross, polling site after flooding
One week after Avoyelles Parish received nearly 30 inches of rain in less than 12 hours, 2 Sisters’ Salsa is opening its parking lot to help the community recover.
Plaucheville business opens parking lot to Red Cross, polling site after flooding
One week after Avoyelles Parish received nearly 30 inches of rain in less than 12 hours, 2 Sisters’ Salsa is opening its parking lot to help the community recover.
WATCH: House Democratic leaders hold hearing on fair elections and voting rights
House Minority Leader Hakeem Jeffries and Democratic lawmakers held a hearing Thursday on defending fair elections and voting rights.
Valve Quietly Walks Back Steam Machine 4K 60 FPS Performance Claims
Valve's Steam Machine has earned more than its fair share of skeptics, thanks to performance claims and more recently its unfortunate pricing. More recently, though, Valve has seemingly taken some of this criticism to heart and silently changed some of those performance claims on the Steam Machine p...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
After wins by democratic socialists, centrist Democrats unite to push back
Thirteen Democratic House members and candidates announced their support for an initiative that commits them to centrist principles.
The Politics Hour: The big winners in MD's primary elections
Leading Democratic nominee for Montgomery County Executive Will Jawando talks about his message to voters, dark money, and data centers. Plus, Tara Jackson wins the Democratic nomination for Prince George's County State's Attorney and WAMU's Alex Koma on D.C. lawmakers greenlighting the budget.
House Freedom Caucus pressures Senate to pass SAVE America Act
The House has passed the bill three times, but it is stalled in the Senate where it lacks the votes to pass
Trump keeps turning Republican wins into loyalty tests
President Donald Trump’s moves on housing, FISA, Iran and Washington projects are creating new headaches for Republicans trying to show voters they can govern.
PsychPlus Acquires Koa Health
Houston, Texas-based psychiatry practice PsychPlus has acquired Koa Health, a London-based digital therapeutic and B2B-focused digital mental health
PsychPlus Acquires Koa Health
Houston, Texas-based psychiatry practice PsychPlus has acquired Koa Health, a London-based digital therapeutic and B2B-focused digital mental health
Why cannabis businesses need to apply for DEA registration now – and why states must help
Cannabis businesses should apply for DEA registration by a Friday, June 26 deadline. And states should be helping them.
Orange County Politics and Public Health Tangle in Sacramento
A debate over if supervisors should be on the board of CalOptima is opening broader questions on politics in healthcare.
Romeo Doubs' Exit Could Raise the Stakes for Jordan Love in Green Bay
Jordan Love and the Green Bay Packers are eyeing a bounce-back campaign in 2026. The Packers opened the 2025 season with a strong start, posting a 9-3-1 record through their first 13 games, before a flurry of injuries derailed Green Bay's Super Bowl hopes. Since taking over as Green Bay's starter under center, the Utah State product has shown flashes of a top-five signal-caller, though the team hasn't yet made it past the divisional round under his leadership.
Rubio’s spin on the Iran MOU sounds different from Trump and Vance
For more than a week, America’s top diplomat was conspicuously quiet about something that would have seemed very much in his wheelhouse: a nascent agreement with Iran. But now Secretary of State Marco Rubio is speaking.
Trump Keeps Undercutting Republicans’ Message, Squandering His Own Trifecta
Divisions between the president and his party on Capitol Hill have muddled Republicans’ midterm pitch to voters, and have crippled the G.O.P. at what should be the peak of its power.
http://democrats-energycommerce.house.gov/media/press-releases/pallone-opening-remarks-health-subcommittee-markup-15-bills
Energy and Commerce Committee Ranking Member Frank Pallone, Jr. (D-NJ) delivered the following opening remarks today at a Health Subcommittee markup of 15 bills:
Following Apple, Microsoft Dramatically Hikes Xbox Prices, Again
Just hours after Apple increased its hardware prices across the board, Microsoft is doing the same with its Xbox consoles. For the third time.
Trump’s politics of emergencies leaves GOP allies scrambling again
In upending plans to sign a bipartisan housing bill, the president illustrated one of his favored tactics: declaring a policy preference to be an emergency.
Americans Are Not Buying White House’s Trump Health Claims
New polling shows what a majority of Americans really think of the explanations about 80-year-old Trump.
Health Subcommittee Markup of 15 Bills Addressing Illicit Drugs and Health Care Price Transparency
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
Lionel Richie takes ill, cuts opening concert of tour short
The Rock & Roll Hall of Famer, who is 77, told his 10,000 fans he was feeling dizzy but performed for nearly an hour before leaving the stage.
19th Hole party zone brings entertainment, drinks, and live music to Wichita Open
The 19th Hole at Crestview Country Club has become one of the tournament’s signature attractions, offering live entertainment, local vendors, cocktails, games and a lively atmosphere throughout the four-day event.
Extreme heat and health: Policy guide reveals what communities need to know
Blistering temperatures exacerbated by high humidity are not just uncomfortable but dangerous. Across Canada, and in communities throughout southwestern Ontario, rising temperatures are affecting people's ...
Tech: House Science advances AI bills
The House Science Committee advanced a bipartisan bill that would codify increasingly prominent artificial intelligence oversight work being done by the Commerce Department.
Ranking Big 12 recruiting classes via average commit distance
The Big 12 recruiting landscape continues to change as programs continue to shuffle throughout the conference. Texas Tech is pushing to sign the nation’s No. 1 class in the 2027 cycle and it firmly sits atop the league’s recruiting rankings. The Red Raiders are the only Big 12 team with a top-25 haul, per the […]
RFK Jr. urged Iowa candidate to make deal to help GOP win House seat, per audio recording
The health secretary urged Iowa Libertarian candidates to drop out of key races to help Republicans keep control of Congress, according to interviews and a recording obtained by The Post. The effort highlights mounting GOP anxiety over the battle for the House.
Democratic socialists cemented power in New York. Next, the rest of the country?
The wins would not have been possible without significant support from Black and Latino voters who favored them over establishment candidates.
Government Scientists Fired by Trump Launch New Website for Sharing Climate Data
"Trusted climate information should not disappear when politics change."
ServiceNow: An Excellent Business Trading at a Discount
ServiceNow is doing everything right, and its stock price should begin to reflect that fact.
Supreme Court lets Trump end temporary protections for migrants
The decision could allow the government to deport hundreds of thousands of people starting this year.
LaMelo Ball trade grades: The Hornets' logic makes sense, but what is Minnesota's thought process?
Fox Sports renews Gold Cup rights, adds Nations League
Fox Sports is going to remain a player in the international soccer game for several more years to come. Although the rights for the 2030 World Cup are up for grabs, Fox made the announcement on Wednesday night that the Gold Cup, the CONCACAF championship tournament, will remain with the company. In addition, Fox is…
Wilmer Valderrama Launches Social Media Marketing Company
Wilmer Valderrama‘s WV Entertainment has launched a social media marketing company WV Social House.
Grand Theft Auto VI pre-orders open, but don’t expect a physical copy
The blockbuster launch is expected to dwarf the box office takings of the year’s biggest movies with one industry analyst predicting it could make $1bn within an hour
Aurora program breaks down barriers to one of the most expensive youth sports
New Enhanced Services Pilot Brings Home Health Aides to New Yorkers in Their New Homes
New York, NY – NYC Health + Hospitals’ Housing for Health initiative today announced Bridge to Care, a pilot program funded by The Leona M. and Harry B.
Semi-communal 'compound houses' in Ghana affect how people participate in political activity
Could the precise architectural form of your residence influence how much you participate in politics? A new study by MIT scholars finds this to be exactly the case—at least in Accra, Ghana, where many ...
Texas Democrats head to convention with optimism, but questions about November remain
The Texas Democratic Convention begins Thursday in Corpus Christi. The three-day convention features several national and statewide figures in the party — this while polls show Democratic candidate James Talarico essentially even with his Republican opponent for U.S. Senate, Attorney General Ken Paxton.
Axios House: Sports must prove it can scale as live events surge
Sports is now the single biggest driver of live viewing, and everyone is scrambling to own a piece of it
These Seattle bar and cafe owners are bringing fresh energy to the Ave
From the new owner of the beloved College Inn Pub to a new wave of cafes and teahouses, these University District business owners are reinvesting in the Ave.
US economy grew at 2.1% in first quarter
First-quarter GDP grew at 2.1%, above the expected 1.6%, as equipment investment in AI and computers along with consumer spending led growth.
Trump to meet House speaker in attempt to break legislative gridlock
Trump suddenly scrapped the signing of a pivotal bipartisan housing bill yesterday, demanding the Senate pass his voter ID bill
Apolosign Digital Calendar and Portable TV for Family Organization and Home Entertainment
NEW YORK, June 25, 2026 (GLOBE NEWSWIRE) -- Apolosign, a smart family display brand serving more than one million households worldwide, today an...
Scientists discover how a single cell builds a brain with 170 billion cells
How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.