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Board Approves Horvath Motion to Evaluate Warner Bros Acquisition and Protect LA Entertainment Jobs - Supervisor Lindsey P. Horvath

Today, the Board approved a motion to analyze the potential economic impacts of the proposed Paramount-Warner Bros. merger and advance efforts to protect the region’s entertainment workforce.

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Mar 24 • 3:45 PM EDT • Entertainment • lindseyhorvath.lacounty.gov
Episode 68, Science for Success, Tissue testing and Potassium

By Dusty Sonnenberg, CCA, Field Leader, a project of the Ohio Soybean Council and Soybean Check-off In Episode 68, Dusty visits with soybean researchers involved in the Science for Success program. Science for Success provides timely, cutting-edge best management practices by coordinating the uni

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Mar 24 • 3:02 PM EDT • Science • ocj.com
TDN Business Hour: The Global Thoroughbred Market

Mark Taylor, Marshall Gramm, Anthony Trimarchi and Case Clay join the TDN Business Hour podcast hosted by Najja Thompson.

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Mar 24 • 2:43 PM EDT • Business • thoroughbreddailynews.com
Analysts' new AI stock rating system reveals these winners and losers

William Blair analysts revamped how they are rating AI stocks. In their new framework, seven stocks emerged as winners, while four were downgraded.

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Mar 24 • 1:01 PM EDT • Business • businessinsider.com
The Oura Ring 5 Just Leaked a Year Early

If these images are real, this is the first look at the Oura Ring 5.

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Mar 24 • 11:40 AM EDT • Technology • gizmodo.com
World TB Day: Scaling workplace healthcare interventions

Four lessons from the End Workplace TB initiative could help other private sector-led campaign coalitions to scale their workplace healthcare programmes.

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Mar 24 • 9:36 AM EDT • Health • weforum.org
12 Life Science Startups Named to SLAS Europe 2026 Innovation Showcase Program

SLAS has named the 12 companies selected to participate in its Innovation AveNEW program at the SLAS Europe 2026 Conference and Exhibition.

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Mar 24 • 9:27 AM EDT • Science • clpmag.com
Ayaneo says selling its Windows gaming handheld ‘is no longer sustainable’

The RAM shortage claims another victim.

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Mar 24 • 9:05 AM EDT • Technology • theverge.com
Registration opens for hands-on ocean science program for teachers this summer

Registration has officially opened for BLOOM Educators, Bigelow Laboratory for Ocean Sciences' professional development program offering hands-on training for middle and high school teachers.

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Mar 24 • 8:00 AM EDT • Science • penbaypilot.com
Apnimed Announces Strategic Monetization of Shionogi-Apnimed Sleep Science (SASS) Joint Venture Stake for $150M and Royalties, Strengthening Focus on its Wholly-Owned OSA Program, AD109

/PRNewswire/ -- Apnimed, Inc., a pharmaceutical company developing an oral drug product candidate, AD109, that is designed to address a root cause of...

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Mar 24 • 8:00 AM EDT • Science • prnewswire.com
Helping seniors thrive through connection

ETSU is one of three universities nationwide selected to develop senior nutrition programs.

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Mar 24 • 8:00 AM EDT • Health • news.etsu.edu
New Maine law seeks to help parents afford childcare costs

Since 2019, the state has spent more than $145 million in state and federal funds on childcare and early education programs, according to the governor’s office.

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Mar 24 • 7:25 AM EDT • Politics • spectrumlocalnews.com
Anthropic says Claude can now use your computer to finish tasks for you in AI agent push

Anthropic and its rivals are trying to ramp up capabilities of AI agents after OpenClaw went viral earlier this year.

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Mar 24 • 6:00 AM EDT • Technology • cnbc.com
Ultrahuman ramps up U.S. push with Ring Pro as Oura tightens its grip

Ultrahuman pushes back into the U.S. with Ring Pro, as Oura strengthens its lead in a market driving 60% of global demand.

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Mar 24 • 6:00 AM EDT • Technology • techcrunch.com
Eurozone, Asian Business Activity Slows as Iran War Ramps Up Uncertainty

The war has driven up energy prices and uncertainty, while a cooling of new orders points to longer-lasting harm if the conflict continues or escalates.

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Mar 24 • 5:29 AM EDT • Business • wsj.com
On 16th anniversary of Affordable Care Act, Va.'s federal lawmakers and health leaders weigh risks

Virginia's Democratic federal lawmakers and health care providers met in Hampton Roads to discuss lapsed parts of the ACA program and steep cuts to Medicaid funding.

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Mar 24 • 5:25 AM EDT • Health • virginiamercury.com
Galaxy Z Fold 8 specifications leak again

Samsung is expected to launch the Galaxy Z Fold 8 in July 2026, and its specifications have allegedly leaked ahead of the launch event.

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Mar 24 • 2:01 AM EDT • Technology • sammobile.com
Trump’s ultimatum to Iran was almost up. Then he found an offramp

President Trump postponed his threat to strike power plants in Iran, citing “productive conversations” with the Iranians. But officials said the talks were in an early stage and not substantive.

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Mar 23 • 11:27 PM EDT • Politics • seattletimes.com
Victorian business fined for telling influencers to lie about paid Instagram post in first of its kind penalty

Watchdog also fines PhotobookShop for editing a paid review from an influencer who had described process as ‘fiddly’

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Mar 23 • 9:59 PM EDT • Business • theguardian.com
35 Products I Bet You Haven’t Seen Yet, But I Also Bet You’ll *Love*

Nobody panic, but Summer Fridays just released a caramel-vanilla perfume.

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Mar 23 • 9:01 PM EDT • Technology • buzzfeed.com
Milledgeville teen runs car detailing business in school, wins $1,000 in chamber contest

At 19 years old, Kyan Silas has started a successful business and received second place in the youth entrepreneur program, landing him a $1,000 prize.Kyan Sila

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Mar 23 • 8:47 PM EDT • Business • wgxa.tv
Charlotte native and rapper DaBaby announces music festival coming to Concord this summer

CONCORD, N.C. (QUEEN CITY NEWS) — Charlotte native and rapper DaBaby is bringing a major hip-hop festival to the area this summer. The Grammy-nominated rapper, who will be kicking off a nationwide tou...

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Mar 23 • 8:39 PM EDT • Entertainment • yahoo.com
From One Major to Three in Four Years: Connecting Data Science, German and Linguistics at Montclair

In a German language program for local children and on an archive translation project, Isabella Zarate Gonzalez shows how Montclair’s mix of STEM, world languages and community engagement helped her connect her interests into a single path

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Mar 23 • 8:00 PM EDT • Science • montclair.edu
NIU Today - Two business graduate degrees reimagined with a bold AI focus

Beginning this fall, two graduate degrees within the College of Business’s Department of Operations Management and Information Systems (OM&IS) will be reimagined to emphasize their focus on artificial intelligence and analytics. Formerly known as the Master of Science in Data Analytics (MSDA) degree, this degree has been transformed into the Master of Science in Business...

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Mar 23 • 8:00 PM EDT • Business • niutoday.info
The Politics of Forbearance

A broad range of views on democracy to help break the stalemate caused by partisan conflict.

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Mar 23 • 8:00 PM EDT • Politics • democracyproject.org
Aramark Sports + Entertainment’s Culinary Creativity Takes the Field at Eight MLB Stadiums as Umpires Shout “Play Ball!”

As Major League Baseball prepares to welcome fans back for another season of unforgettable moments, Aramark Sports + Entertainment (Aramark; NYSE: ARMK) is stepping up to the plate with a new lineup of culinary innovations, collectible souvenirs, and fan‑driven experiences debuting across eight MLB stadiums nationwide.

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Mar 23 • 7:56 PM EDT • Entertainment • aramark.com
Advocates want $150M collectively in state budget for food assistance programs

Advocates say the need is dire as more New Yorkers are having to make difficult choices when it comes to how they spend their money.

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Mar 23 • 7:42 PM EDT • Politics • spectrumlocalnews.com
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Miami starts cutting property tax rebate checks for seniors

'This program is about delivering real relief where it matters most.'

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Mar 23 • 6:43 PM EDT • Politics • floridapolitics.com
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Microsoft Aims to Supercharge Windows Performance and Cut RAM Waste in 2026

Perhaps this would help return some of the goodwill it lost in 2025.

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Mar 23 • 5:38 PM EDT • Technology • pcmag.com
After patient deaths, Idaho budget committee approves restoring cut Medicaid mental health programs

The Idaho Legislature will consider restoring mental health programs the state cut to comply with the governor’s order for budget cuts.

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Mar 23 • 5:34 PM EDT • Health • idahocapitalsun.com
MacBook Neo Silences Critics Over 8GB RAM Being Inadequate; Can Open 60 Apps In Unison While Windows Laptop Powers Off Performing The Same Task

A YouTube channel decided to take the MacBook Neo for an apps stress test and opened up 60 apps at the same time to see if that 8GB RAM will be sufficient

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Mar 23 • 5:31 PM EDT • Technology • wccftech.com
Veterinary Science Certificate Program promotes early steps on career path

Rural communities face a growing shortage of veterinary professionals, creating challenges for pet owners and livestock producers alike.

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Mar 23 • 4:59 PM EDT • Science • agrilifetoday.tamu.edu
Henderson County launches crisis response program for behavioral health emergencies

In Henderson County, officials say a new program is already working to respond when someone is in crisis, often through a 911 call.

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Mar 23 • 4:53 PM EDT • Health • wlos.com
Funding restored for crucial behavioral health programs, leaving related services as is

The Joint Finance-Appropriations Committee voted to restore funding for two crucial behavioral health programs. Leaving other supplemental services on the table

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Mar 23 • 3:53 PM EDT • Health • idahonews.com
Linden Entertainment Signs ‘Your Friends & Neighbors’, ‘Tow’ Director Stephanie Laing

EXCLUSIVE: Linden Entertainment has signed Emmy-winning director, writer, and producer Stephanie Laing for management. Laing is coming off the theatrical release of her new film, Tow, a comedy-drama s...

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Mar 23 • 12:19 PM EDT • Entertainment • yahoo.com
Trump was offered an off-ramp to the DHS shutdown but he didn’t take it

President Donald Trump was presented Sunday with a potential off-ramp to the more than month-long Department of Homeland Security shutdown: fund every part of the department except enforcement operations by Immigration and Customs Enforcement, two sources familiar with the conversations told CNN.

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Mar 23 • 11:33 AM EDT • Politics • cnn.com
Peregrine Road performs at the Jesup

BAR HARBOR — On Thursday, April 9, at 5:30 p.m., the Jesup will host a free Music and Conversation program with Peregrine Road (Rachel Bell and Karen Axelrod). Peregrine Road

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Mar 23 • 10:51 AM EDT • Entertainment • mdislander.com
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Microsoft Realizes It’s Epically Screwed Up Windows 11 as Users Rage at Copilot AI Crammed Everywhere

Windows VP Pavan Davuluri effectively admitted outright that the company went too far to shove AI down users' throats at all costs.

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Mar 23 • 10:45 AM EDT • Technology • futurism.com
Health in a Handbasket: Chips & Dip

Today we're putting a healthy spin on a snack we all know and love.

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Mar 23 • 9:04 AM EDT • Health • 13wham.com
WSU launches bilingual video series to help beekeepers improve colony health

Researchers with WSU's Honey Bee and Pollinators Program have produced a new video series giving novice keepers a strong introduction to best practices and the science of apiculture, in both Spanish and English.

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Mar 23 • 9:00 AM EDT • Health • news.wsu.edu
By Director Mr. Sakurai, Kirby Air Riders: Development Insights — Part 5 - News

Join Kirby Air Riders director Masahiro Sakurai as he shares insights into the development and details behind some of the game's modes and features. Check out the rest of the interview Part 1: Air Ride and Top Ride Part 2: Cramming everything into S…

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Mar 23 • 8:00 AM EDT • Technology • nintendo.com
Small Business Promotion Week: Hey Honey Marketplace

Jennifer Reeves, nurse turned boutique owner, came up with the idea for Hey Honey Marketplace, a boutique on Abram Street that aims to not just be a store but a community gathering place for women.

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Mar 23 • 8:00 AM EDT • Business • arlingtontx.gov
Banijay Entertainment Dials Up Global Scripted with Premium Series Mania Slate

Media and entertainment powerhouse, Banijay Entertainment, today unveils its premium scripted offering for Series Mania, showcasing a broad range of high-end drama from across its global portfolio. As the number one European studio in scripted, with more than 100 titles launching each year, the company continues to demonstrate its scale, creative strength, global reach and […]

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Mar 23 • 6:26 AM EDT • Entertainment • banijay.com
Microsoft Plans Better Windows 11 RAM Management and a Smoother User Experience

Microsoft recently announced a plethora of changes coming to Windows 11 to reshape the operating system into a completely stable and enjoyable experience. Today we learn that Microsoft plans a major background usage overhaul with future updates, focusing on RAM usage and overall memory management, s...

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Mar 23 • 5:49 AM EDT • Technology • techpowerup.com
What events are happening in the South Bend area from March 23 to 29?

A variety of events will keep you busy this week. Attend a screening event, catch a concert, attend a lecture or play.

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Mar 23 • 4:47 AM EDT • Entertainment • southbendtribune.com
Small swings, high drama: why UK polls are less volatile than they seem

In what is beginning to look like a fragmented five-party system, small swings carry outsized political consequences

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Mar 23 • 3:00 AM EDT • Politics • theguardian.com
AI Swarm Attacks Are Coming, Is Your Business Ready?

Leaders need a new cybersecurity playbook for the agentic era, with stronger governance, faster response systems, workforce awareness, and up-to-date security frameworks.

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Mar 23 • 2:27 AM EDT • Business • forbes.com
2026 Best Business Schools | How Alumni Rate Their Undergraduate Business Degrees

Alumni rate their undergraduate business programs in Poets&Quants’ 2026 ranking, evaluating academic experience, career preparation, advising, and how well their degrees support long-term career goals.

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Mar 23 • 12:00 AM EDT • Business • poetsandquantsforundergrads.com
5 Laptops With Better Specs Than The MacBook Neo For The Same Price

The MacBook Neo starts at $600, but these five laptops deliver better RAM, storage, and larger screens for the same price or less.

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Mar 22 • 9:17 PM EDT • Technology • bgr.com
Vermont may look across borders to help bring in business

House passes bill to create sister state program for economic development.

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Mar 22 • 8:55 PM EDT • Business • wcax.com
Chelan Co. Sheriff’s Office secures nearly $55k in funding for behavioral health unit

The Chelan County Sheriff’s Office has secured nearly $55,000 in outside grant funding to support and expand its behavioral health crisis response program, allowing the agency to add training, equipment and other resources without using county funds.

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Mar 22 • 8:42 PM EDT • Health • kiro7.com
Jerry Hanlon, longtime Michigan football coach, dies at 96

"Michigan Athletics has lost one of the finest ambassadors and mentors our football program has ever known," U-M AD Warde Manuel said in a statement.

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Mar 22 • 8:34 PM EDT • Sports • sports.yahoo.com
IMCOM-E international business advisor helps service members, families with tax relief programs

IMCOM-E international business advisor helps service members, families with tax relief programs

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Mar 22 • 8:00 PM EDT • Business • dvidshub.net
9/11 survivors’ health care secured for next 15 years

The World Trade Center Health Program secures funding for 15 more years, ensuring healthcare access for 9/11 survivors and victims' families.

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Mar 22 • 6:28 PM EDT • Health • yahoo.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Introducing the 2026 Northeast Arkansas Outstanding Business Awards finalists - Talk Business & Politics

For several weeks, we have been soliciting the region’s business community for nominations for our first recognition program of the year: the Northeast Arkansas Outstanding Business Awards, presented by Arvest...

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Mar 22 • 11:00 AM EDT • Business • talkbusiness.net
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Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo

One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening

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Mar 22 • 8:30 AM EDT • Entertainment • pasadenanow.com
Inflatable homes on the Moon? Scientists reveal how humans could live there sooner than expected - Futura-Sciences

How could humans live on the Moon? Although the Artemis program has taken a more cautious approach following recent delays, the goal remains the same: send astronauts back to the lunar surface. Doing so will require systems that allow crews to stay there for several days, or even several weeks....

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Mar 22 • 7:00 AM EDT • Science • futura-sciences.com
Get ready to vote in the next Detroit Community Choice Awards

The awards program seeks to shine a light on outstanding businesses in Wayne, Oakland and Macomb counties.

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Mar 22 • 6:02 AM EDT • Business • freep.com
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Central Mass. by the Numbers, Sunday, March 22

A look at business news in Central Mass. over the past week

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Mar 22 • 5:03 AM EDT • Business • telegram.com
Barricade That Kept Out the Far Right in France Is Crumbling

Franck Leclere made his way through the timber-framed houses of Chalons-en-Champagne and joined a crowd of people in symbolic white shirts to demonstrate against the rise of the far right in France.

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Mar 22 • 3:15 AM EDT • Politics • bloomberg.com
We are living in a period of political anti-intellectualism. But in pop culture, clever is the new cool

At the very moment Trump’s rambling speeches and meme–fied inanity threaten to overwhelm us, fashion, music and film are moving in the opposite direction

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Mar 22 • 2:00 AM EDT • Politics • theguardian.com
Madison Black Chamber of Commerce prepares 8th business awards recognition program

The Madison Black Chamber of Commerce is hosting its 8th Black Business Awards Recognition and Exhibition Program on Thursday.

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Mar 21 • 11:50 PM EDT • Business • wmtv15news.com
Black Family Wellness Expo brings people together for day of health education

The Black Family Wellness Expo returned to Roselawn Saturday.

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Mar 21 • 11:13 PM EDT • Health • local12.com
Deals: Galaxy S26 series gets its first price drop, the Pixel 10 series drops even further

Meanwhile, the 2025 MacBook Airs are getting cheaper too - not quite as cheap as the Neo, but they are an important alternative for those who need more RAM.

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Mar 21 • 9:31 PM EDT • Technology • gsmarena.com
Friction without contact discovered as magnetic forces break a 300-year-old law

Researchers have uncovered friction without contact—driven entirely by magnetic interactions. As two magnetic layers slide, their internal forces compete, causing constant rearrangements that dramatically increase resistance at certain distances. This creates a surprising peak in friction instead of a steady rise, breaking a long-standing physics law.

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Mar 21 • 8:00 PM EDT • Science • sciencedaily.com
Sanford Sports launches in Black Hills region

Sanford Sports is expanding into the Black Hills, bringing its research-backed training programs and services to athletes across the region.

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Mar 21 • 7:00 PM EDT • Sports • kotatv.com
Illinois vs VCU live updates: March Madness Round 2 game highlights, how to watch

VCU's upset of North Carolina was a highlight of March Madness Round 1. What do Rams have in store for Illinois in Round 2? Follow our live updates.

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Mar 21 • 6:08 PM EDT • Sports • usatoday.com
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Halide co-founder is suing former partner for bringing source code to Apple

Startup drama.

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Mar 21 • 5:02 PM EDT • Technology • theverge.com
Gov. Stein announces $8.5 million for WNC small business recovery after Helene

The funding will assist 13 projects through the North Carolina Department of Commerce’s Small Business Infrastructure Grant Program, continuing the state’s response to the impacts of Hurricane Helene.

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Mar 21 • 2:30 PM EDT • Business • foxcarolina.com
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UFC Fight Night odds, lines, predictions, time: Evloev vs. Murphy picks from proven MMA expert

Expert Kyle Marley reveals his UFC Fight Night best bets for the March 21 London card on Paramount+

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Mar 21 • 1:21 PM EDT • Sports • cbssports.com
NCDHHS launches new program looking to expand number of mental health providers in state

In North Carolina, the demand for social workers in the state is growing as substance use and mental health service needs increase. The North Carolina Department of Health and Human Services launched the Public Service Leadership Program, a collaboration between the NCDHHS and 25 higher education institutions in the Social Work Coalition on NC Work Development, to help with that demand.Alongside the announcement of the new program on March 2, the NCDHHS released its first “State of North Carolina’s Mental Health and Substance Use Services Workforce Report” supported by UNC’s Behavior Health Workforce Research Center and Sheps Health Workforce NC.

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Mar 21 • 12:53 PM EDT • Health • elonnewsnetwork.com
Farmers and rural community members can access free mental health resources

KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.

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Mar 21 • 12:14 PM EDT • Health • cbs2iowa.com
Hannah Hidalgo's historic season hits March Madness. What to know about Notre Dame star

Notre Dame star Hannah Hidalgo set several program, ACC and NCAA records this season. Here's what to know about the junior guard in March Madness.

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Mar 21 • 12:03 PM EDT • Sports • usatoday.com
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Hubert Davis' future at North Carolina in serious doubt as pressure mounts after historic collapse

Sources tell CBS Sports that Hubert Davis' future at North Carolina is in serious doubt after a historic NCAA Tournament collapse, with boosters losing faith and questioning their willingness to fund the program.

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Mar 21 • 10:42 AM EDT • Sports • cbssports.com
An Iranian-American political science expert talks about Iran's nuclear program

NPR's Scott Simon speaks to Ariane Tabatabai, the Public Service Fellow at Lawfare, about the nature of Iran's nuclear program, and whether it, as President Trump has said, posed an "imminent threat."

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Mar 21 • 9:36 AM EDT • Science • kuow.org
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UFC Fight Night odds, lines, predictions, time: Evloev vs. Murphy picks from proven MMA expert

Expert Kyle Marley reveals his UFC Fight Night best bets for the March 21 London card on Paramount+

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Mar 21 • 8:46 AM EDT • Sports • cbssports.com
Sacramento businesses recover after string of burglaries; 1 suspect arrested

Sacramento police have arrested a man believed to be connected to 11 burglaries affecting local businesses, as authorities work to prevent further incidents.

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Mar 21 • 2:27 AM EDT • Business • kcra.com
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Former Rams 5th-round edge rusher signing with Panthers

Former Rams OLB Nick Hampton, who was a fifth-round pick in 2023, is signing with the Panthers.

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Mar 20 • 9:41 PM EDT • Sports • sports.yahoo.com
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Full circle: Sean McVay collecting former players on coaching staff

Robert Woods joins Brian Allen on Sean McVay’s Rams coaching staff

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Mar 20 • 9:26 PM EDT • Sports • sports.yahoo.com
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Heavy smoke rises from commercial building in Providence

A fire broke out inside of a business in Providence Friday night.

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Mar 20 • 9:02 PM EDT • Business • turnto10.com
New AI tool predicts cancer spread with surprising accuracy

Researchers have discovered that cancer spread isn’t random—it follows a kind of biological “program.” By studying colon tumor cells, they identified gene patterns that signal whether a cancer is likely to metastasize. Their AI model, MangroveGS, can predict this risk with about 80% accuracy and even works across multiple cancer types. This could transform how doctors decide who needs aggressive treatment and who doesn’t.

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Mar 20 • 8:00 PM EDT • Science • sciencedaily.com
Press Release - Girls in STEM Program from Keystone Science School

Delivered in an all-girl+ learning environment, Keystone Science School’s Girls in STEM programs encourage participation, collaboration, leadership, and confidence.

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Mar 20 • 7:45 PM EDT • Science • yellowscene.com
Microsoft Is Finally Ready to Make Windows 11 Less Terrible After Bloating It With AI Crap

Less Copilot, better search, and more taskbar customization are apparently in the pipeline.

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Mar 20 • 6:45 PM EDT • Technology • gizmodo.com
ABC10

News for Northern California - including weather, traffic, sports and Originals content. The YouTube home of ABC10 in Sacramento!

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Mar 20 • 5:31 PM EDT • Health • youtube.com
Pentagon policy limiting independent press access is unlawful, judge rules

A federal judge on Friday voided various parts of a restrictive press policy rolled out by Defense Secretary Pete Hegseth last year, ruling that they trampled on the constitutional rights of reporters who seek to cover the US military from within its sprawling headquarters.

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Mar 20 • 5:17 PM EDT • Politics • cnn.com
Hubert Davis buyout: What it would cost UNC to move on from coach after first-round NCAA Tournament exit

The Tar Heels' second straight first-round NCAA Tournament exit adds to growing questions about the program's direction

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Mar 20 • 5:03 PM EDT • Sports • cbssports.com
Federal judge sides with Washington in case over transgender youth health care

A federal judge said Thursday he will rule in favor of Washington state and a coalition of 20 other states and the District of Columbia, blocking what they call

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Mar 20 • 3:38 PM EDT • Health • komonews.com
Microsoft confirms a major Windows 11 update with faster Explorer, reduced Copilot, and more

Windows 11 in 2026 will bring taskbar fixes, better performance, lower RAM usage, and fewer updates as Microsoft responds to user feedback.

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Mar 20 • 3:00 PM EDT • Technology • windowslatest.com
Reparations Committee opens up applications for Black Business grant program

The city’s Reparation Committee, in collaboration with Oakton College, is launching a grant and training program to support Black entrepreneurs at

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Mar 20 • 2:55 PM EDT • Business • evanstonroundtable.com
Should I care about Tom Brady, Logan Paul and flag football? I need to know

The Fanatics Flag Football Classic features NFL stars, Team USA and, yes, celebrities. With flag football now on the Olympic program, should we care?

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Mar 20 • 2:14 PM EDT • Sports • usatoday.com
Mark Cerny Confirms Frame Generation "Should Be Seen At Some Point On PlayStation Platforms"

"I look forward to discussing this more in the future!"

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Mar 20 • 2:01 PM EDT • Technology • digitalfoundry.net
NVIDIA DLSS 5 Takes 2D Frame and Motion Vectors as Input

The public is still learning more about DLSS 5 technology, and NVIDIA is gradually revealing additional details. In a conversation between YouTuber Daniel Owen and NVIDIA's GeForce Evangelist Jacob Freeman, we discover that DLSS 5 essentially takes 2D frames and motion vectors as input, applying its...

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Mar 20 • 1:08 PM EDT • Technology • techpowerup.com
Utica Zoo Celebrates Spring and Ramadan with Special Events

Families and friends are invited to celebrate the first day of spring and the end of Ramadan with a day full of activities at the Utica Zoo.

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Mar 20 • 11:57 AM EDT • Entertainment • wktv.com
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AI is running rampant in health care. They want to fix that.

Researchers at Northeastern are creating a universal guide for how to ethically implement AI in health care.

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Mar 20 • 11:22 AM EDT • Health • news.northeastern.edu
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At least one dead after Sacramento Business 80 crash

At least one person is dead after a crash on a major Sacramento freeway.

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Mar 20 • 11:10 AM EDT • Business • kcra.com
Nine Winters Bakery is closing in Cambridge: 'I'm choosing my family'

In an Instagram post, owner Marissa Ferola addressed the closure and said the last day of service is at the end of the month.

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Mar 20 • 10:28 AM EDT • Business • boston.com
Abramson advancing research at intersection of health, inequality and AI

Corey Abramson's research earns him a year in residence at the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University.

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Mar 20 • 8:00 AM EDT • Health • news.rice.edu
'Anthony's purpose.' Canton mother remembers son with tribute art show

Monica Ramos of Canton is honoring her late son with an art show. And she wants to help others who struggle with mental health like her son did.

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Mar 20 • 5:59 AM EDT • Health • cantonrep.com
Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout

More than 2 million Virginians rely on state social services like Medicaid and the Supplemental Nutrition Assistance Program, while about 400,000 Virginians get their health insurance through the state marketplace.

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Mar 20 • 5:25 AM EDT • Health • virginiamercury.com