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Trey Hendrickson was "looking forward" to playing with Maxx Crosby
Less than 24 hours after the Ravens' trade for Maxx Crosby fell through, the team agreed to terms with Trey Hendrickson.
BravesVision is officially on DIRECTV
The Atlanta Braves announced another major carriage agreement hours before Opening Day.
Live: UFC Seattle early weigh ins results
Ultimate Fighting Championship (UFC) is just over 24 hours away from the upcoming UFC Seattle mixed martial arts (MMA) event, booked for tomorrow night (Sat., March 28, 2026) on Paramount+ from inside Climate Pledge Arena in Seattle, Washington. UFC Seattle will be headlined by the middleweight main event between former champion Israel Adesanya and 185-pound […]
Colorado Springs business groups launch new networking initiative to help local business owners succeed
Local organizations are teaming up to host "4-Business After Hours," a series of events designed to connect business owners and provide resources for success in the Pikes Peak region.
Anthropic tweaks timed usage limits to discourage Claude demand during peak hours
: AI biz makes some Claude conversations more costly to manage capacity
S.T.A.L.K.E.R. 2: Cost of Hope - First Details About the Major Heart of Chornobyl Expansion
A massive new storyline, two new regions - including the Chornobyl Nuclear Power Plant - that can take dozens of hours to explore, and much more. All in the S.T.A.L.K.E.R. 2: Cost of Hope expansion announced at #XboxPartnerPreview:
Saros Preview - Speaking My Language
We played Saros for three hours to learn the language of Housemarque's latest roguelite and we had an excellent time.
Intel and LG Display may have beaten Apple and Qualcomm with the best laptop battery life ever
Over 26 hours of web browsing in one test.
Marion firefighters spend several hours at scene of overnight business fire
Fire breaks out at a business in Marion.
VIDEO: Car flees Parma Heights police, crashes into business
Local police in the early hours of Tuesday, March 24, pursued a speeding vehicle that fled a traffic stop, then crashed into a business storefront.
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
TSA lines are so bad that United, Delta waive change fees
Some airlines are waiving change fees or fare differences for passengers affected by hourslong waits at airport security.
I spent 4 hours in line at the TSA, and the situation felt dangerous
A couple traveling to Costa Rica for their anniversary vacation spent four hours at the TSA, missed their flight, and spent the night at the airport.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
New C8 Corvette Grand Sport Makes Surprise Debut at 12 Hours of Sebring
The first mid-engined Grand Sport dons a widebody and red hashmarks, with the car's full reveal coming later this week.
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.
France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Oil prices face new pressure as US and Iran trade threats
Trump said the US would attack Iran's power plants if it didn't reopen the Strait of Hormuz in 48 hours. Iran responded on Sunday with is own threats.
Webb Telescope spots “impossible” atmosphere on ancient super Earth
Astronomers have uncovered surprising evidence of a thick atmosphere surrounding TOI-561 b, a scorching, fast-orbiting rocky planet once thought too extreme to hold onto any gas. Using NASA’s James Webb Space Telescope, researchers found the planet is far cooler than expected for a bare rock, hinting at a heat-distributing atmosphere above a churning magma ocean. This strange world—where a year lasts just over 10 hours and one side is locked in eternal daylight—may even be rich in volatile materials, behaving like a “wet lava ball.”
PSN Service Returning on PS5, PS4 as Brief Outage Took Service Offline
Taken offline for roughly two hours
Your 2026 NCAA Basketball Tournament Viewing Guide: March 21, 2026
Bummed about only one men’s tournament game at a time for 6 hours today? THAT’S WHAT THE WOMEN’S TOURNAMENT IS FOR!
Health Ministry: 303 people hospitalized in war with Iran and Hezbollah in past 24 hours
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Shelby’s Trio hosts Chamber of Commerce Business After Hours
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12 hours, 4 games, 1 unavoidable truth: There is nothing better than the first day of March Madness
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Home Health Care Aides Say It’s Time to End ‘Inhumane’ 24-Hour Shifts
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Mullin under microscope by Senate colleagues over temperament, stolen valor and ICE in tense DHS confirmation hearing
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WNBA, players union reach agreement; season to start on time, reports say
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EU Inc proposal seeks to rival US in innovation by easing startup creation
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Artists, vendors frustrated over payment issues from Colchester business
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Green Bay Fire issues update on business blaze still active after 24 hours
Green Bay Metro Fire is giving an update on a business fire that’s been active for more than 24 hours.
+++ "You dreamed it, we built it": BMW M Motorsport is turning the concept for a racing version of the BMW M3 Touring, originally presented as an April Fools’ joke in 2025, into reality +++ The BMW M3 Touring 24H will hit the track as a spectacular highlight for motorsport fans in the “Green Hell” +++ The BMW M3 Touring 24H will make its racing debut next weekend as part of the Nürburgring Langstrecken Serie +++
+++ "You dreamed it, we built it": BMW M Motorsport is turning the concept for a racing version of the BMW M3 Touring, originally presented as an April Fools’ joke in 2025, into reality +++ The BMW M3 Touring 24H will hit the track as a spectacular highlight for motorsport fans in the “Green Hell” +++ The BMW M3 Touring 24H will make its racing debut next weekend as part of the Nürburgring Langstrecken Serie +++
Three-quarters of nine-month-olds in England have ‘daily screen time’
Study showed average time on screens each day was 41 minutes, with some watching more than three hours a day
Scientists just discovered a tiny signal that volcanoes send before they erupt
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The Unoptimized Tensor G5: The Smaller Battery In Samsung Galaxy S26 Lasts 3 Hours Longer Than The One In Pixel 10 Pro XL
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Final 68-team bracketology for 2026 Women’s NCAA Tournament
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Tinkatink Community Day April 2026: Shiny Odds, Bonuses & Gigaton Hammer Tinkaton
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I'm in my late 70s and work out 7 days a week
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Hours After Announcing Donald Glover as Yoshi in the Super Mario Galaxy Movie, Nintendo Has Now Revealed Its New Yoshi Game Release Date
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Trump contradicts himself on Iran repeatedly in just a few hours
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Teens are sleeping less than ever and screens aren't primarily to blame
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24 Hours With Nike’s C.E.O. as He Races to Win Back the Sports World
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Game Preview: Philadelphia Flyers @ Pittsburgh Penguins 3/7/2026
Who: Philadelphia Flyers (28-22-11, 7867points, 6th place Metropolitan Division) @ Pittsburgh Penguins (31-17-13, 75 points, 2nd place Metropolitan Division) When: 5:30 p.m. ET How to Watch: Local broadcasts on SportsNet Pittsburgh and NBC Sports, streaming on ESPN+ Pens’ Path Ahead: The Pens have less than 24 hours between puck drops this weekend. They’re back in action Sunday afternoon against […]
Trump’s college sports roundtable: Two hours of talk, with few solutions
President promises an executive order to fix college sports, while the SCORE Act receives a boost. Here's a breakdown of the meeting.
Man convicted in U.S. political assassination plot he tied to Iranian paramilitary
The jury needed little more than two hours to convict Asif Merchant, 47, of murder-for-hire and terrorism charges that carry the possibility of life in prison.
‘Rhythm & Booms’ will turn the Franklin Institute into a late-night science and cocktail party
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House GOP leaders call on Rep. Gonzales to end reelection campaign
House Republican leaders made the request hours after Gonzales admitted, for the first time, to an affair with a staffer who later died after setting herself on fire.
HHS and Education Dept. partner on nutrition curriculum for medical schools
Fifty-three medical schools have agreed to provide at least 40 hours of nutrition education or a competency equivalent starting this fall
Gambling and sports betting: Are we calling a public health risk ‘entertainment’? (Letters)
“Now consider modern gambling. It is available 24 hours a day, in every pocket. It is aggressively promoted across broadcasts and social media. It is designed for seamless engagement, with in…
Cuba hit by widespread blackout; Ecuador expels Havana’s ambassador, staff
Cuba's Ambassador to Ecuador Basilio Gutierrez and his diplomatic staff were given 48 hours to leave Quito.
Virginia Science Olympiad at UMW Celebrates STEM Learning Across the Commonwealth
Eliora Teshome held her breath while her balsawood bridge was put to the test. The Lake Braddock Secondary School student from Burke, Virginia, had worked for months – in her school’s testing lab, during library hours and late at night – with fellow eighth-grader Rebecca Huang to build the miniature model into a winning weight-bearing […]
West Hollywood approves extended hours for 2 local businesses amid statewide movement for later last call times
In the wake of two West Hollywood businesses being allowed to extend their late-night hours, there is now a push for a later last call in the city. This comes amid a movement to extend business hou…
Magic rout visiting Wizards behind Paolo Banchero’s 37 points
ORLANDO, Fla. — Entering Tuesday’s game against the Wizards, the Magic knew they’d already be without Franz Wagner, who is managing an extended rehab of a left high ankle sprain. Then, in the hours leading up to tipoff, Orlando learned it would also be without Anthony Black (right quad contusion) for the second game in a row and Wendell Carter Jr. (left ankle soreness) while hosting Washington ...
Following This 3-Hour Rule Before Bed Could Support Healthy Blood Pressure and Blood Sugar
New research links not eating for a few hours before bed—and 13 to 16 hours overnight—with better heart health and blood sugar markers.
I spent $2,500 and traveled 14 hours to get back to my son in the UAE
Nicky Lazou scrambled to fly into Oman and cross the land border into the UAE when airspaces closed, to be with her son.
Highlights from the first few hours of Bill Clinton’s deposition on Epstein files
US House committee releases videos of the Clintons’ Epstein testimonies
Bill and Hillary Clinton last week faced hours of questioning from lawmakers about the convicted sex offender
California measles outbreaks linked to pockets of unvaccinated residents
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Trump says U.S. military operations in Iran likely to last at least a month
The remarks came just hours after Defense Secretary Pete Hegseth declined to say how long the United States expected to take to complete its mission in the Middle East.
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During a crisis like what is now unfolding in the Middle East, a president receives a net assessment prepared from intelligence and military sources. It might evaluate the balance of forces, leadership dynamics and strategic calculations — without making policy recommendations. Its purpose is clarity: a baseline from which decisions can be made.
Accel Entertainment (ACEL) To Report Earnings Tomorrow: Here Is What To Expect
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24 Unexplained Experiences That Will Give You Chills
"I stayed frozen under the blanket for what felt like hours, listening to footsteps that never quite reached my bed."
MI politicians react to U.S. strikes on Iran: ‘Risking American lives’
Hours after the U.S. and Israel launched a major attack on Iran, Michigan politicians have begun responding with a mix of praise and calls for Congressional oversight.
OpenAI reaches Pentagon agreement as Trump orders Anthropic off federal systems
OpenAI strikes Pentagon AI deal hours after President Trump orders federal agencies to phase out rival Anthropic over military AI safety concerns and policies.
Her husband wanted to use ChatGPT to create sustainable housing. Then it took over his life.
Kate Fox says Joe Ceccanti was the ‘most hopeful person’ before he started spending 12 hours a day with a chatbot
OpenAI strikes a Pentagon deal, hours after Anthropic was cut
OpenAI has reached a deal with the Pentagon over the use of its AI models, CEO Sam Altman announced late Friday.
'We can only hope': Local business owners say violent crime is hurting bottom lines
A Thursday night shooting, killing a pizza shop employee, shut down a shopping center for hours, forcing other businesses to close and miss out on profits. City leaders say violent crime not only impacts its target, but also the local economy.
Nintendo Switch Pokémon Games Are on Sale for Pokémon Day
You can save big on Nintendo Switch Pokémon Games today, with several getting significant discounts as part of Pokémon Day. But, the deals are only available for 24 hours, so check them out ASAP.
Competition at quarterback – The Splash Zone 2/27/26
Welcome to the Splash Zone, the quickest way to get your day started off right. We bring you a rundown of Miami Dolphins news from the last 24 hours.
Hillary Clinton derides her Epstein deposition as GOP ‘political theater’
Hillary Clinton appeared before the House Oversight Committee as she began hours of closed-door testimony in front of the Republican-led panel.
Douglas County business owners must report shoplifting within 96 hours
After the WeWork bankruptcy, the coworking industry was looking shaky. Not anymore.
"People think coworking just for startups interested in beer pong and crazy happy hours, but that’s not true. Companies that have been established for over 100 years are embracing it."
South Carolina Health Official 'Encouraged' by Sharp Two‑week Drop in Measles Cases
Feb 25 (Reuters) - South Carolina has reported lower cases of measles two weeks in a row, offering an encouraging sign that the outbreak may be easing, a state health official said in a briefing on Wednesday. "The hard work and long hours that frontline, often entry-level epidemiologists,
Sisters Welcome Babies Hours Apart at NYC Health + Hospitals/North Central Bronx - NYC Health + Hospitals
In a remarkable coincidence, sisters Jenny Aguilar and Wendy Aguilar gave birth to healthy babies just hours apart at NYC Health + Hospitals/North Central
Flutter Entertainment (FLUT) To Report Earnings Tomorrow: Here Is What To Expect
Global online betting powerhouse Flutter Entertainment (NASDAQ:FLUT) will be reporting results this Thursday after market hours. Here’s what investors should know.
Family of Mother with Mental Health History Who Died in Custody Speaks Out: 'We Lost a Best Friend'
Tammy Shipley died in jail after drinking more than 60 cups of water over the course of 12 hours.
The Minkah Fitzpatrick rumors – The Splash Zone 2/24/26
Welcome to the Splash Zone, the quickest way to get your day started off right. We bring you a rundown of Miami Dolphins news from the last 24 hours.
Training for New ICE Agents Is ‘Deficient’ and ‘Broken,’ Whistle-Blower Says
The former official will appear with congressional Democrats, who also released documents indicating significant reductions in instructional hours for recruits.
Pokémon GO Events This Week: 23 February
Pokémon GO’s February 23 to March 1 week has us entering the final week of Precious Paths! Enjoy a bumper week of daily raid hours, the build up to Kalos Tour, and the epic Global Kalos Tour event! Plus the weekly rotating Spotlight and Raid Hours, Dynamax Battles and Mega Raids. ⭐Highlights Raid Boss Change […]
U.S. continues to add to its gold tally at the Milan-Cortina Olympics
The United States continues to make a strong showing at the Milan-Cortina Olympics as it adds to its already strong medal tally heading into the final hours of the Games.
Dutch high school science hours to drop up to 30% under new curriculum
Dutch secondary school students are set to face a significant reduction in science class hours as a new national curriculum takes effect in August 2027, raising concerns among educators about the future of technically skilled graduates, Trouw reports.
Justice Department says interim US attorney is fired hours after Virginia judges appoint him to replace Trump loyalist
Just hours after the federal judges in the Eastern District of Virginia appointed a new interim US attorney to replace Trump loyalist Lindsey Halligan, the administration said he is fired.
Trump warns he's considering limited strikes as Iranian diplomat says proposed deal is imminent
President Donald Trump has warned that limited strikes against Iran are possible even as the country’s top diplomat says Tehran expects to have a proposed deal ready in the next few days following nuclear talks with the U.S. Trump’s remarks Friday came a few hours after Iranian Foreign Minister Abbas Aragchi said on MSNOW’s “Morning Joe” show that his country was planning to finalize a draft deal in “the next two to three days” to then send to Washington
Sports betting comes to campus
An abundance of sports betting ads has flooded streaming platforms, YouTube, and social media since sports betting became legal in Missouri just two months ago. “It was weird seeing LeBron [James] on my For You page telling me to bet instead of seeing him dunk on somebody,” junior Julián Villamil said. Villamil placed his first bet just a few hours before our conversation.
Business After Hours: An evening of fun, networking, and entertainment
The Albany Chamber of Commerce announced in a Facebook post that Business After Hours is taking place on Feb 17. at 5 PM at Up 2 U Entertainment, Albany’s newest entertainment destination.
Trying Qatar Airways' business class flights for 26 hours; mostly good
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Dolphins begin purging roster – The Splash Zone 2/17/26
Welcome to the Splash Zone, the quickest way to get your day started off right. We bring you a rundown of Miami Dolphins news from the last 24 hours.
Local county environmental services to extend business hours due to outage
The Montgomery County Environmental Services has extended its business hours to accommodate customers in making payments due to an outage that has affected their vendor payment system.
Sacramento police investigate string of seven business burglaries within roughly 24 hours
Sacramento police investigate string of seven business burglaries within roughly 24 hours
Stop eating 3 hours before bed to improve heart health
A simple shift in your evening routine may give your heart a measurable boost. In a new study, adults who stopped eating and dimmed the lights three hours before bed and extended their overnight fast by about two hours saw improvements in blood pressure, heart rate, and blood-sugar control — without cutting calories.
Scientists reveal what really happens after you die
People may be conscious for several hours after they have died, a study has claimed.
As Market District businesses suffer, city speeding up construction
A year-long road closure for park construction in Tallahassee's Market District is causing significant financial strain for local businesses, leading to layoffs and reduced hours.
Search continues for additional suspects in string of Placer County business break-ins
Burglars target 5 businesses in less than 24 hours; authorities track SUV to Sacramento
Monster Hunter Stories 3 Preview: Me and My Pet Rathalos
I spent half a dozen hours with Monster Hunter Stories 3: Twisted Reflection by that point, and got a feel for what it was shaping up to be: a gorgeous RPG that combines the traditional elements of Monster Hunter with a turn-based RPG and a surprisingly compelling cast and narrative that invited me to befriend and train monsters, not just hunt them.
The 3 Hour Rule That Could Boost Your Heart Health
Participants stopped eating and lowered the lights three hours before bedtime, extending their overnight fast by about two hours without cutting calories. Compared with the control group, nighttime blood pressure dropped by 3.5% and heart rate fell by 5%, signaling a healthier pattern during sl
AFCON 2027: What is the truth behind the postponement rumors?
Is AFCON 2027 at risk of being postponed? The truth behind the speculationAFCON 2027 / @thecitizen.co.tzConflicting reports have emerged in recent hours regarding the date of the 2027 Africa Cup of Na...
One simple daily change that could slash depression risk
Swapping just an hour of TV a day for something more active could significantly lower the risk of developing major depression—especially in middle age. A large Dutch study tracking more than 65,000 adults over four years found that replacing 60 minutes of TV with other activities cut depression risk by 11% overall, and by nearly 19% in middle-aged adults. The more time people reallocated—up to two hours—the greater the benefit, with risk dropping as much as 43% in midlife.
New Steam Hit Made Back Its Entire 7 Year Budget In Just 3 Hours
Also: who's ready to watch a live-action remake of Frozen inside Fortnite?
Mewgenics is a breakout hit on Steam: it sold 150,000 copies in six hours, and it's already made its development costs
Mewgenics, the latest release by Edmund Mcmillan and Tyler Glail, has recouped its development costs in a matter of hours.
Mewgenics earns back entire 7 year development budget just 3 hours after launch
Mewgenics launched on Steam after a 14-year journey and surged to the top as a long-running indie legend finally paid off.