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BREAKING: Key Rams Player Is OUT Against The 49ers
Well, so much for seeing Aaron Donald and Myles Garrett together in Week 1. Donald will not travel to Australia with the Rams and has been ruled out for Thursday night’s season opener against the San Francisco 49ers. That’s a major break for Brock Purdy and the 49ers. Donald recently came out of a two-year…
The Business of Building a Medical Practice
In this episode of Entrepreneurial Shades of Gray, Dani sits down with Dr. William Boyd, who has spent more than 30 years building and running his own practices.
Gymnastics, fitness and range of motion: See 4 health-focused business updates in Spring-Klein
There are several health-focused businesses that recently opened or plan to open in the Spring area.
Philz Coffee workers in California file to form union to negotiate new contract
The notice was delivered Tuesday
These Companies Made the Inc. Best in Business List. Here’s What Happened Next
Award winners share how they capitalized on the momentum from their Best in Business recognition.
Game Awards Host Geoff Keighley And PlayStation Architect Mark Cerny Will Start Giving $2 Million To Young Game Designers Each Year
The Nova Games Foundation is a new philanthropic initiative aimed at supporting the next generation of game makers
988: September 8 marks nationwide awareness campaign for mental health crisis lifeline
Georgians are being asked to tell a friend about 988 as part of a nationwide campaign marking September 8.
Patriots-Seahawks Betting Report: Books Need Super Bowl Middle In Opener
A rematch of SBLX will kick off the NFL season. Patrick Everson breaks down the betting action ahead SEA-NE, with books needing a specific result.
Rogers mixed-income community opens after $13 million investment
Three-story, 60-unit Olive Street Apartments recently opened at 700 N. 24th St. in Rogers. Roughly $13 million was invested in the attainable housing project, supported by the Walton Family Foundation....
Meet the Candidate: Ben Ivey seeks 120th District Judge seat
The El Paso Times sent questionnaires to candidates in the 2026 Nov. 3 General Election. Here are answers from 120th District Court judge candidate Ben Ivey.
Dunlap highlights high home heating oil prices in Maine
Dunlap, who faces former Republican Gov. Paul LePage on the Nov. 3 ballot, said Maine continues to be the state where more people rely on home heating oil than any other.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Aspen School District renews membership with Valley Health Alliance
Valley Health Alliance announced today that the Aspen School District has renewed its membership, marking a significant milestone for both organizations.
Berman campaign: “We’re going fishing” – ER nurse and Democrat Mitchell Berman launches first ad of general election in Wisconsin’s First District Congressional race
Spot features Berman fishing and focuses on ending corruption in Washington, contrasting Berman’s working class background and Republican Bryan Steil’s corporate special interests RAYMOND, Wis. — Today, Mitchell Berman, ER nurse and Democratic candidate for Wisconsin’s First Congressional District, launched...
OpenAI releases ChatGPT Images 2.5 with 'sharper details' and 'more precise editing'
In April, OpenAI released upgraded image generation technology with ChatGPT Images 2. Five months later, the company is releasing an...
How to watch the Seattle Seahawks opener against New England
The reigning champions take on the New England Patriots in a Super Bowl LX rematch to start the season, with a unique Wednesday game. Here's why.
Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning
LOS ANGELES (AP) — The mother of Caleb Vazquez alleges in her lawsuit that Park Mental Health Treatment of San Diego failed to intervene despite signs that her 18-year-old son posed an imminent threat to himself and others.
🚨XIs ready: City visit Porto in their European opener
Estádio do Dragão is getting ready to host an electrifying UEFA Champions League opener. Francesco Farioli’s FC Porto come into it on fire after putting together seven straight wins and opening th...
🚨Confirmed XIs: Dortmund host Villarreal in their European opener
The 2026/27 UEFA Champions League kicks off in style at the mystical Signal Iduna Park. Borussia Dortmund come in as favorites, backed by three straight wins and Serhou Guirassy’s firepower up front...
Meet Rachel Chen, the 18-year-old Los Angeles student who expanded a 1997 quantum-math idea to describe entire particle systems with simple diagrams; she won $100,000
At just 18, Rachel Chen has taken a decades-old mathematical idea and expanded it into a visual framework for understanding complex quantum systems, earning her a $100,000 award in the 2026 Regeneron Science Talent Search.
Can This Orlando Magic Trio Exceed Expectations?
New head coach Sean Sweeney aims to ignite a stagnant offense and harness the defensive grit of Paolo Banchero’s crew to solidify Orlando as an Eastern powerhouse.
Jimmy Rolder returns as Lions boast good health ahead of opener
The Detroit Lions roster is fully healthy for practice as key players return ahead of the season opener against Saints.
Apple Releases iOS 26.6.2
Apple today released iOS 26.6.2 with a fix for "an issue that prevents downloading a software update over a cellular connection". The minor software update is rolling out now for the iPhone 11 series and newer. To update your iPhone, open the Settings app and tap on General → Software Update. It might take a few minutes until the update is visible to everyone. iOS 26.6.2 arrives approximately three weeks after iOS 26.6.1, which delivered security fixes.
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Smithsonian chief Lonnie Bunch to retire following clash with Trump admin
Bunch said in a news release Tuesday that he was departing the position he had held since 2019 "with very mixed emotions and heartfelt gratitude"
Next Apple TV's Chip Revealed in Latest Leak
The next Apple TV 4K will be equipped with an A19 or A19 Pro chip, according to evidence in Apple's code uncovered by MacRumors contributor Aaron Perris. In particular, the device's model identifier points towards the A19 generation of chips. Accordingly, the next Apple TV would have 8GB or 12GB of RAM, up from 4GB in the current 2022 model with the A15 Bionic chip.
North Carolina unveils new 988 signs to expand mental health support awareness
The campaign aims to make calling 988 for a mental health crisis as familiar as calling 911 during other emergencies, officials said.
Future Leader: Haven Banks, Director of Marketing & Outreach, MiraSol Health
Haven Banks, Director of Marketing & Outreach at MiraSol Health, has been named to the Future Leaders Awards Class of 2026 by Hospice News. To become
Hundreds rally to protest the planned closure of the Academy of Natural Sciences museum
The crowd was decidedly intergenerational.
As WTC steel beam makes stop in D.C., Trump pledges to never forget 9/11 victims
Trump spoke as part of a Steel Across America tour that has been traveling the country with a salvaged beam from the World Trade Center
As WTC steel beam makes stop in D.C., Trump pledges to never forget 9/11 victims
Trump spoke as part of a Steel Across America tour that has been traveling the country with a salvaged beam from the World Trade Center
As WTC steel beam makes stop in D.C., Trump pledges to never forget 9/11 victims
Trump spoke as part of a Steel Across America tour that has been traveling the country with a salvaged beam from the World Trade Center
TST Best Bets: September 8, 2026
The Los Angeles Angels dropped the series opener yesterday, 5-2, against the Boston Red Sox.
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films....
SKY BLUE CINEMATIX - ENTERTAINMENT - BRAND INTEGRATION : Two Films. One Global Partnership.
Sky Blue Cinematix appointed exclusive worldwide brand-integration partner for two new features from Tested Films.London, UK, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Sky Blue Cinematix, the entertainment and brand-integration division of Sky Blue Media Group, today announced its appointment as the exclusive global brand-integration partner for two upcoming feature films from Tested Films: the action thriller Habeas Corpus and the neo-noir romantic mystery Blurred. Sky Blue Cinematix appointed exclusi
Your Business Is Growing — So Why Aren't You Making More Money? Here's the Revenue Trap Many Founders Fall Into.
More clients, more employees and more revenue can look like success. But if growth isn’t creating more profit, a stronger company and a better life, you may simply be building a bigger job.
Rogers and OEG Sports & Entertainment Extend Strategic Partnership for 10 More Years
EDMONTON, Alberta, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Rogers and OEG Sports & Entertainment (OEGSE), today announced a 10-year extension of ...
NYC releases 170,000 pages of long-sought 9/11 health, air quality records
New York City opened a public portal containing 170,000 pages of 9/11 records sought for years by first responders, survivors and families concerned about Ground Zero health risks
Is Trump’s midterm convention a flop before the doors even open?
Trump says he wants to energize Republican candidates before the midterms. Dozens are keeping their distance anyway.
Baptist Health Paducah to offer 'Monday Night Mammograms' during Breast Cancer Awareness Month
Baptist Health Paducah will recognize Breast Cancer Awareness Month by providing Monday Night Mammograms throughout the month of October.
NYC releases 170,000 pages of long-sought 9/11 health, air quality records
New York City opened a public portal containing 170,000 pages of 9/11 records sought for years by first responders, survivors and families concerned about Ground Zero health risks
State health officials highlight importance of newborn screenings
September marks Newborn Screening Awareness Month.
US targets Iran’s airline industry as part of pressure campaign
The Trump administration took sweeping actions against Iran’s airline industry on Tuesday as part of its pressure campaign on Tehran.
How did CBS Sports grade the Oklahoma Sooners for Week 1 win?
CBS Sports awarded Oklahoma an A- for its dominant win over UTEP in the season opener.
How UC Davis Strengthens the Forensic Science Workforce
Meet UC Davis students and alumni using a forensic science degree to build careers analyzing DNA evidence and chemicals in crime labs.
AstraZeneca’s breast cancer pill gets approval from the FDA
AstraZeneca Plc’s breast cancer pill was approved by the U.S.
Paxton Aide Turned Whistle-Blower Appears in Ad Endorsing His Rival, Talarico
David Maxwell was among the staffers in the Texas attorney general’s office who accused Ken Paxton of abusing the power of his office, allegations that led to his impeachment. Mr. Paxton was acquitted.
Scientists call for joint efforts to preserve nomadic heritage
At the International Scientific and Practical Conference “Cultural Heritage of the World’s Nomadic Peoples: Preservation, Study, and Development”, scholars and experts from 23 countries urged unified action to safeguard the cultural diversity of nomadic peoples and ensure traditions remain alive for future generations, Qazinform News Agency cites Kabar.
Forrest Health rebrands to unite system under one name
HATTIESBURG, Miss. (WHLT) – Forrest Health unveiled a new name, visual identity and brand on September 8, 2026. According to officials, the health system will be known as Forrest. “For …
William Shatner reveals truth behind 'Star Trek' Tribbles scene, sliding doors
LOS ANGELES ― While still helming the U.S.S. Enterprise as rugged Captain James T.
'Practical Magic 2' brings back the magic and the mess
The Owens sisters are as bewitching as ever – multiple generations of them, in fact – in “Practical Magic 2,” even if the sequel might only truly cast a spell
Foster Swift Welcome Hahn and Serra, Strengthens Business Law and General Counsel Services in Southeast Michigan
Attorney Marcy Hahn Attorney Lisa Serra SOUTHFIELD, Mich., Sept. 08, 2026 (GLOBE NEWSWIRE) -- Foster Swift Collins & Smith, PC is pleased to announce that attorneys Marcy Hahn and Lisa M. Serra have joined the firm's Southfield office, further strengthening its business law, corporate counseling, and general counsel capabilities throughout Southeast Michigan. Marcy and Lisa bring a unique blend of practices including fractional general counsel to business owners along with family law representat
David Kerr named GM of Mississippi Mud Monsters
PEARL, Miss. (WJTV) – The Mississippi Mud Monsters announced that David Kerr has been named General Manager of the organization after serving as Assistant General Manager since the club’s launch. Kerr was formally introduced in his new role during a news conference at Trustmark Park on September 8, 2026. “David has been right in the […]
The Business of Building a Medical Practice
We don’t always think about doctors as entrepreneurs, but running a private practice means running a business.
Nevada SBDC bringing hands-on AI training to Reno small businesses
Reno entrepreneurs will get a chance to explore practical ways artificial intelligence can help their businesses.
Names in the News 9-8-26
Appointments and promotions at Constellation Hotels, Emirates, Virgin Atlantic and Hilton
The shift in British policy on Israel is palpable
But progress could be threatened if there is a new more diplomatic government in Israel.
Cambridge Entrepreneur Wins $25,000 in Business Pitch Competition
CAMBRIDGE, WI – Collaborative 523 Inc., in partnership with the Wisconsin Economic Development Corporation, has announced Jacy Eckerman as the winner of the second cohort of its Business Pitch Competition.
Behind the scenes of Hard Rock Casino Tejon’s Third Eye Blind private concert
METTLER, Calif. (KGET) — An extra special concert took place Monday night at Hard Rock Casino Tejon. 17 News got an exclusive behind-the-scenes look at what it takes to prepare for the Third …
Rogers and OEG Sports & Entertainment Extend Strategic Partnership for 10 More Years
Rogers is giving away more than 1,500 tickets to customers throughout season, including 300 for Home OpenerEDMONTON, Alberta, Sept. 08, 2026 (GLOBE NEWSWIRE) -- Rogers and OEG Sports & Entertainment (OEGSE), today announced a 10-year extension of their strategic partnership, keeping Rogers Place as the home of the Edmonton Oilers through 2036. This extension comes as the iconic Rogers Place is celebrating its 10-year anniversary. To mark the occasion, Rogers is awarding more than 1,500 Oilers ti
Watch Reacher and Neagley reunite in the opening scene of the new spinoff (exclusive)
Ahead of the “Neagley” series premiere, watch Alan Ritchson bring Reacher to the Chicago-set series.
In 12 years, Triangle man missed only 1 health insurance payment. He lost coverage
A mistake setting up autopay proved costly for this Morrisville family. Here’s what happened — and how you can avoid it.
No Evidence That Sugar Substitutes Harm Weight, Health, or Sweet Taste Preferences
New review of three major EU-funded trials shows swapping sugar for non-nutritive sweeteners may help with weight loss maintenance, while broader "sweet taste" exposure appears largely neutral for health.
The US wants a stronger battery supply chain. China has a decades-long head start
The Trump administration is attempting to strengthen the U.S. battery supply chain and reduce the country’s dependence on China, but analysts and industry executives say current funding is small compared with what would be needed to substantially challenge China’s dominance, CNBC reports. In August 2026, the Department of Energy awarded $500 million to seven companies […]
New report finds little short-term health risk from air pollutants in South Portland, Portland
Six years of air sampling found benzene levels above state guidelines at one location and elevated acrolein levels across the study area.
Roundup: Energy employment / Small business confidence / Maritime woes
Jobs in transition: Energy sector employment fell about 1% nationwide and in Louisiana from 2024 to 2025, with Louisiana losing 1,131 jobs to reach roughly 160,000 workers. The decline was driven largely by automation, policy changes affecting renewable energy, and shifting economics, while traditional energy industries such as coal and nuclear saw job growth. Despite […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Republicans descend on Dallas for midterm convention
Dallas is hosting the GOP midterm convention this week.
Trump’s Bombardier threat puts aerospace supply chain at risk
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the U.S. In response, the maker of private jets noted that many components for its planes, including the wings, are produced in the U.S. and its supply chain relies heavily on U.S. companies. Since Canada-U.S. […]
Ask Pete Dougherty your questions about the Green Bay Packers
Pete Dougherty is taking questions as the Green Bay Packers head into the Week 1 season opener against the Minnesota Vikings in Minneapolis.
Hong Kong students drop in global rankings for maths, science and literacy
City’s students drop out of global 10 in Pisa’s science section – the first time since Hong Kong joined international assessment.
SC's Emerging Biotech Industry Receives National Recognition
Genetic Engineering & Biotechnology News (GEN) recently named the Palmetto State among its “Regional and State Clusters to Watch” in its first-ever Next 10 U.S. Biopharma Clusters report, highlighting emerging life sciences ecosystems beyond...
What to know about this week's Republican midterm convention
The two-night convention will kick off in Dallas on Wednesday
Seiche Launches Marine Science And Technology Department With Three New Leaders
Seiche has established a Marine Science & Technology Department uniting marine mammal specialists, acousticians, and engineers under three new department heads. The move expands the company's scientific and technical capabilities across offshore wind, renewable energy, and broader marine environmental monitoring.
Adley Rutschman's three-run HR off Pesky Pole carries Red Sox past Angels, 5-2
Adley Rutschman hit a three-run homer off the Pesky Pole in right field, Brayan Bello pitched five scoreless innings in his first start since early June and the hot-again Boston Red Sox beat the Los Angeles Angels 5-2 on Monday afternoon.
Trump threatens Canadian jetmaker Bombardier
U.S. President Donald Trump has threatened to ban the sale of aircraft from Canada’s Bombardier unless it manufactures planes in the United States
Apple Acquires Startup Working on 'Breakthrough Sensing Technology'
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The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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