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Sandra Bullock and Jennifer Aniston joke about both dating Tate Donovan: ‘Shared a boyfriend’
The longtime pals both dated the “Damages” star in the 1990s.
Anthropic Says It Blocked Possible Efforts to Build Biological Weapons
In a new report, the A.I. start-up added that it could not determine if the research was legitimate or nefarious, leading the company to shut down the work.
U.S. Supreme Court again blocks Republican-backed Missouri congressional map
The SCOTUS decision is the latest in a whirlwind of legal decisions shifting the lines of Missouri’s congressional districts.
Supreme Court again blocks new Missouri congressional map favoring GOP
The ruling is the latest twist in an intense legal drama that has plunged the state into electoral confusion.
Antonelli's Mercedes contract blocks two-wheel plan with Valentino Rossi
MotoGP title challenger Marco Bezzecchi has opened up on his close relationship with Formula 1 championship leader Kimi Antonelli. The pair of Italians are competing for the title in the top tiers of two-wheeled and four-wheeled racing and could well make history this season.
Supreme Court blocks Missouri’s attempt to use newly drawn Republican congressional map
Missouri Secretary of State Denny Hoskins had sought to use the new Republican map despite the Missouri Supreme Court saying that he is barred from doing so.
Taiwan's political institutions 'failing' under divided government: U.S. scholar
Taiwan's current political deadlock reflects institutional weaknesses that were largely obscured during years of unified government, a U.S. scholar said Wednesday at a symposium in Taipei.
Seahawks beat Patriots 13-10 in Super Bowl rematch
Backup quarterback Drew Lock led two late scoring drives and the Seattle Seahawks intercepted Drake Maye three times in the fourth quarter to overcome an early injury to starter Sam Darnold and beat the New England Patriots 13-10 in a Super Bowl rematch.
Blockbuster Myles Garrett trade defined NFL offseason and future of two teams
Myles Garrett was traded from the Browns to the Rams during the 2026 NFL offseason. Here's the full details of how the blockbuster came together.
Nicole Kidman opens up about making 'Practical Magic 2'
Nicole Kidman talks to The Tennessean about returning as the Owens sisters with Sandra Bullock in the long awaited \
Ali Ruwaih Named VP & GM of TSL Business at Lockheed Martin
Ali Ruwaih has spent more than two decades at Lockheed Martin, working in aviation, radar and international naval programs.
Bringing evidence into focus with Web of Science DeepR
Web of Science DeepR brings together Web of Science discovery and full text from ProQuest and other sources to create a more connected experience and unlock new possibilities for AI-assisted research.
Jaxon Smith-Njigba picks up where he left off
Despite the early switch from Sam Darnold (hip) to Drew Lock, Jaxon Smith-Njigba still topped 100 yards and scored Seattle's lone touchdown.
Modders Unlock DLSS Multi Frame Generation For RTX 30-Series "Ampere" GPUs
After porting DLSS 5 to every recent NVIDIA generation, the modding community now seems to be turning its focus to Frame Generation. A new mod called DLSSG SM86 lets GeForce RTX 30-series owners run DLSS Multi Frame Generation in 2X and 4X modes, a feature NVIDIA officially reserves for RTX...
Seahawks news: Drew Lock speaks up on unexpected night amid Sam Darnold injury
The Seattle Seahawks raised their Super Bowl LX banner on Wednesday night. Then, they took on the New England Patriots in a rematch of the big game. Quarterback Sam Darnold exited with an injury in this game. But backup Drew Lock was ready to answer the challenge. Lock entered the game in the first quarter, and he went to work. He finished the game […] The post Seahawks news: Drew Lock speaks up on unexpected night amid Sam Darnold injury appeared first on ClutchPoints.
Seahawks Get Concerning Sam Darnold Injury News Amid Patriots Game
After one series, there’s concern about Seattle Seahawks QB Sam Darnold. After a 3rd-and-6 play, Dre’Mont Jones sacked Darnold for a five-yard loss, but after the play, he limped off the field. When the Seahawks were on defense, Darnold went into the blue tent to examine him. In the very next series, backup Drew Lock […] The post Seahawks Get Concerning Sam Darnold Injury News Amid Patriots Game appeared first on HEAVY.
‘Get This Man a Cart’ – Sports Doctor Calls Out Patriots for Making A.J. Brown Limp to Locker Room After Injury Scare
It has been a shocking start to the 2026 NFL season. A unique Wednesday night broadcast to begin the year was already going to be an adjustment.
Who is Sam Darnold's backup after Week 1 injury?
The good news: Drew Lock has starting experience. The bad news: what Drew Lock has done with said experience.
Viewpoint: Unlocking Europe’s wildfire data
Europe is already investing in the science, technology and infrastructure needed to understand, prevent and fight wildfires. Copernicus provides satellite-based Earth observation and environmental information, while the European Forest Fire Information System provides information on fire danger and forest fires across Europe. Weather and climate systems add forecasts of heat, drought, wind and humidity; historical fire databases show where fires have occurred; and researchers generate increasingly detailed knowledge about fuels, fire behaviour, forecasting, modelling and risk management. Meanwhile, new European research projects are adding digital twins and other tools to this growing ecosystem.However, these data do not necessarily sit together, nor are they necessarily described, structured or governed in ways that allow them to be used together. Much of the information is public, but some is commercially held. Some is sensitive. Some is subject to legal, security or operational restrictions. Even when data can be legally accessed, different systems may use different formats, terminology and rules.Europe therefore faces an unusual paradox: we have vast amounts of relevant information to respond to the wildfire challenge, but not the means to bring it together. For example, a wildfire researcher or emergency service might need to ask whether a particular combination of vegetation, drought, wind and topography has historically been associated with rapid fire spread. The relevant information may exist in several institutions, using different systems and subject to different conditions of access.The challenge is to conduct an authorised analysis that interacts with these sources, combines the results and respects the rules imposed by each data custodian.An important part of the answer can be found in the Fair principles, the idea that data should be findable, accessible, interoperable and reusable. Developed more than a decade ago, these principles have become a central reference point for modern data stewardship, making it easier for people and machines to find data, understand what it means and determine whether it can be reused.Readability by machines is essential, since AI systems will be key to meeting the data challenge. Bring analysis to the dataThe proposition is not to give an AI system unrestricted access to sensitive databases. Quite the opposite. The goal is to make it possible for approved algorithms to go to the data, rather than requiring sensitive data or large datasets to be copied to wherever the analysis happens.Imagine an analysis asking a series of questions of different data stations. At one station it might examine weather and climate data; at another, historical fire records; at another, experimental measurements of fire behaviour. The algorithm does not need to download everything. It can operate within the environment permitted by each data custodian and return only the results that the rules allow to leave.This is sometimes described as data visiting, and related approaches already exist in areas such as federated analysis and federated learning.Sensitive data should therefore not be treated as a free-for-all for machines. This requires appropriate governance at multiple levels. Access needs to be authenticated and authorised. The purpose of an analysis should be defined. The code or model being run should be controlled. Data custodians should be able to specify what can be queried and what results can leave their environment. Activities should be auditable and human oversight should remain where the consequences require it.In other words, the objective is not to trust AI with the data. It is to design systems in which AI never has more access than it needs.As open as possible, as closed as necessaryFair data should also not be confused with open data. Some wildfire data should be openly available. Other information may legitimately need to remain restricted because it concerns critical infrastructure, security, commercial interests, privacy or operational capabilities. The principle should be: as open as possible, as closed as necessary.The important point is that restricted data should not automatically become unusable data. If machines can discover what information exists, understand its meaning, establish where it came from and determine the conditions under which it can be used, authorised analyses can potentially be carried out without the underlying data ever leaving the environment in which it is protected.Restricted data can still be Fair and machine-actionable.This is also an important question of data sovereignty. European institutions should not have to surrender control of their data to a handful of technology platforms in order to benefit from AI. Nor does Europe need to start again by building one giant repository for every piece of wildfire information. The better approach is to connect what already exists.This is the principle behind emerging approaches such as Tryangle, developed through the Leiden Initiative for Fair and Equitable Science. Rather than creating another centralised data warehouse, the approach seeks to provide an interoperable layer through which approved algorithms can visit distributed data sources while respecting the rules of their custodians.In this way, a data station can remain where it is. Its custodians can retain control. Existing databases and applications do not have to be abandoned. What changes is their ability to communicate with other systems through common, machine-readable descriptions, access rules and interoperability mechanisms.But approaches like this need data that meets the Fair principles. Only then can an interoperable ecosystem safely begin to turn fragmented information into collective intelligence.Data infrastructure is wildfire infrastructureThe implications of this approach are entirely practical. Firefighters could gain better intelligence about local and evolving risks. Land managers could test prevention strategies using more comprehensive information about fuels, weather and past fires. Researchers could compare evidence across ecosystems without repeatedly moving huge datasets between institutions. Smaller regions and resource-constrained teams could access analytical capabilities without having to build large data infrastructures themselves.Europe is already investing heavily in satellites, databases, research programmes, forecasting systems and scientific expertise. The question is whether we will connect those investments well enough to turn them into actionable intelligence.That requires policymakers and funders to treat data infrastructure as seriously as physical infrastructure. Data generated or supported through European public funding should be Fair, verifiable and machine actionable by design, wherever legally and ethically possible.Related articlesData Corner: Europe’s burning need for wildfire mitigation researchClimate monitoring must remain a global enterprise, experts sayIn practice, that means funding not only the production of data, but also the infrastructure that makes data usable across systems: metadata, provenance, interoperability, access mechanisms and governance. Where data must remain restricted, we should ensure that it can still be securely discovered, verified and used for authorised analysis.Initiatives such as the European Open Science Cloud offer an existing framework through which these principles can be put into practice. What is needed now is to accelerate implementation and make them a standard part of how Europe funds and builds research and innovation systems.We do not need another generation of disconnected databases. The data is already there. The opportunity is to make it work together, securely, responsibly and quickly enough to help prevent the next fire, rather than simply document the last one.Jean-Claude Burgelman is professor emeritus at the Free University of Brussels (VUB) and editor-in-chief at Frontiers Policy Lab. For more than 20 years he held leading roles in research and innovation policy at the European Commission.
Booger McFarland will hold Week 1 game against Michigan in potential CFP debates
The Michigan Wolverines officially get credit for a win over Western Michigan in Week 1, but most of the sports world now believes they were rescued by an improper ruling from referees who put time back on the clock and allowed for a last-second Hail Mary touchdown. The NCAA reportedly will not entertain an appeal…
Appeal is pending with SCOTUS over USPS mail voting dispute
The USPS rule requires state election offices to supply names and addresses of registered voters to USPS.
Sandra Bullock makes rare comment about ex-husband’s cheating scandal: ‘Really dark time’
Appeals court declines to block ruling in favor of Missouri’s gerrymandered map
The decision marked another salvo in Missouri’s chaotic redistricting saga that has drawn national attention.
Apple announces first-ever foldable iPhone, starting at $1,999
The screen will be compatible with the iPhone Pencil, currently available only for iPad users, and can also be unlocked with Apple Watch, according to Apple.
Trump administration proposes dropping huge swath of immigrants from U.S. census
The proposal would block immigrants in the country legally from being counted in the 2030 census and would drop some questions about race and ethnicity.
Biology Professor Earns Prestigious Fulbright Appointment
College of Charleston professor, Andrew Shedlock, will deliver high-impact STEM and AI education to faculty and students in Vietnam through the prestigious Fulbright Specialist Program.
Jacksonville council shuts door on neighborhood storage locker proposal
Citizens speak out, and unanimous council cites city’s historic charm and community backlash in voting to quash business plan that also included retail The Jacksonville City Council said no to […]
The Tate brothers must stay locked up during their UK extradition fight, US judge says
A federal judge in Miami has ruled that social media influencers Andrew and Tristan Tate must remain in custody as they fight extradition to the United Kingdom.
Community members raise concerns about Flock cameras, New Chauncey
The addition of Flock cameras and updates to the New Chauncey neighborhood plan led to community concerns being voiced at Tuesday’s city council meeting.
NVIDIA Brings Real-Time AI to Broadcast, Sports and Global Streaming at IBC
At IBC, NVIDIA is announcing a major expansion to NVIDIA AI for Media to unlock new ways to understand motion, verify and enhance video, localize programming and build AI-powered media applications.
Increasing the Lead-Safe Certified Workforce in North Dakota
Learn how North Dakota is working to improve lead safety by providing trainings for the local contractor workforce.
How Social Media and AI Chatbots Are Reshaping Youth Mental Health, and What Congress Can Do About It
It’s hard to move legislation in Washington, DC right now. Congress seems deadlocked on even commonsense ideas. But there is one spot where we still see consistent bipartisan collaboration: youth mental health. That’s because the youth mental health challenge is vast. Nearly half of teenagers and two-thirds of young adults regularly experience mental health distress, yet only a small … Continued
Is 'Practical Magic 2' worth watching? The sequel took 28 years to happen — and critics say the reunion is complicated.
Sandra Bullock and Nicole Kidman return as the Owens sisters alongside Joey King and Maisie Williams in the witchy cult classic's long-awaited sequel.
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
Boston Bruins lock up young center Fraser Minten
The Boston Bruins believe they have a rising star in Fraser Minten and they put that belief in action by signing the center to a seven-year, $50.4 million extension.
VA Health Records Overhaul Stalls Despite Restart Push
VA's electronic health records modernization hits another roadblock. Learn why the fourth attempt faces delays and what it means for veterans' care.
Becky G expands her block in new album ‘Baraja Bendita’
LOS ANGELES — This past February, Becky G was decked in a tiger-print Roberto Cavalli coat, preening for photos on the streets of Milan: a 13-hour flight away from LAX,
Becky G expands her block in new album ‘Baraja Bendita’
LOS ANGELES — This past February, Becky G was decked in a tiger-print Roberto Cavalli coat, preening for photos on the streets of Milan: a 13-hour flight away from LAX,
What Cathy Engelbert’s successor owes WNBA players
The players aren’t a problem the next commissioner must solve. They are the answer to unlocking the league's full value.
Library cards unlock more than books
September is Library Card Sign-Up Month, and the Haywood County Public Library is highlighting the many ways a free library card can save residents money while opening the door to
Five Plays: Ole Miss First Quarter
Louisville went down to Nashville and battled Ole Miss to the final second on the clock. There were a lot of questions that the Cards needed to answer quickly, with the main one being how Lincoln Kienholz would play in his first career start. But UofL came out with a great plan, and they took […]
Competing court orders add confusion to Missouri congressional elections
Dueling court orders have created new uncertainty for Missouri's congressional map just eight weeks before Election Day. A federal judge on Tuesday temporarily blocked the state from using its old
Trump plans to ban imports of some Canadian dairy, alcohol
WASHINGTON — The United States escalated its trade war with Canada, moving to block imports of some alcoholic beverages, dairy products and motorcycles, as well as seeking to bar Canadian
September 8 Locker Room with Dexter McNabb
GREEN BAY, Wis. (WFRV) – The first episode of Local 5’s “Locker Room” aired live on Tuesday, kicking off the start to the 2026 NFL season. This week’s guest was former Green Bay Packers fullback Dexter McNabb, who played for the team during the 1992 and 1993 season. He then took a gap year and […]
Repairman snares alleged air-conditioner vandal above Houston business
A repairman was able to block the escape route.
Chinese scientists find a hidden atomic structure that unlocks methane
Scientists found that a tiny atomic structure that forms on nickel oxide during methane conversion is more effective than the metallic nickel long believed to drive the reaction. The discovery allowed a low-nickel catalyst to rival one containing 10 times more metal, potentially opening the door to cheaper and more efficient industrial catalysts.
Helping Children Unlock the Science of Reading
For children who struggle to read, even a single page can feel like a puzzle everyone else already knows how to solve. Certified reading specialist and author Christie Welsby is helping families na…
Maryland Coach Mike Locksley Makes Little Slip to Kick Off UConn Week
UConn fans might come up with a chant out of the word "Toledo" before the Huskies and Terrapins meet Saturday.
The 98 Biggest TV Show Flops, Bombs and Misses in the First Half of 2026
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) In July, I updated my look at how the “streaming bubble” popped since 2023, showing the decline in streaming TV shows over time. But after compiling and analyzing and writing about over one hundred TV show flops in the first half of 2026—I counted 99 “nominees” and there are even more honorable mentions—I couldn’t have told you that the number of shows is going down. When it comes to scripted, English-language TV shows, it feels like we have as many bombs as ever. I don’t keep a specific count, but some streamers probably had as many flops as they’ve ever had.1 That’s right, it’s time for part two of my analysis of the biggest flops, bombs and misses on streaming in the first half of 2026. Two weeks ago, I took a look at films. Today, TV shows. If you want to read the full methodology for how I assemble this list, you can find it at the bottom of this article. In short, this list is… ...scripted and unscripted TV shows,...from the nine major streamers,...in the US (using US-only ratings),...excluding true crime, kids and foreign-language shows,...that got no/poor ratings,...from Jan-2026 to the end of June-2026. Reminder: this article does not represent my personal opinion—many of these shows are great!—but I follow the data, and a miss is a miss and a bomb is a bomb. Also, price matters. If a TV show costs north of $100 million, it needs to get lots and lots of streaming viewership to justify that budget. As with past editions, I ordered this list by streamer, going from best (fewest flops) to worst (the most misses)—taking the size of the flops into consideration—and like the last edition, three or four streamers vied to take the win/loss of having the most flops. (But the actual winner is no surprise.) I try to avoid tooting my own horn too much, but seriously, in just under 5,000 words (including the methodology section) I provide a mostly comprehensive overview of the eight major streamers (Netflix, Disney+, Prime Video, Hulu, HBO Max, Peacock, Paramount+, and Apple TV) for the first half of the year, mentioning most of their hits and all their misses. It summarizes the entire first half of 2026! If you want to support this work, please subscribe. Subscribe Tubi Big Mood Boarders The Freak Brothers Twenty Twenty Six Honorable Mentions: Busted on Bodycam, Deestroying the Pitch, Destination World Cup 2026 I don’t think that Tubi spends all that much making or (mostly) licensing these original TV shows—Big Mood, Boarders and Twenty Twenty Six all come from the UK—but they’re not free and they didn’t chart anywhere. Winner: The Freak Brothers Have you even heard of this show? It’s an animated comedy...that’s on its third season! And Pete Davidson, Woody Harrelson, John Goodman and Tiffany Haddish all provide voice talent for it. Yes, animated shows don’t cost as much as live action shows, but cheap isn’t free! So a show with this level of talent needs to perform better. Disney+ Daredevil: Born Again Star Wars: Maul – Shadow Lord Honorable Mentions: Behind the Attraction, Donna Hay Coastal Celebrations, We Call It Imagineering Disney+ doesn’t make all that many original shows anymore. They had two flops, and one was animated. Their one not-a-miss show, Wonder Man, got just good enough viewership to not be considered a “miss”...but it’s since been cancelled. At this point, Disney has pivoted entirely away from making big budget TV shows for Disney+ to making...almost nothing for Disney+? Sure, Disney’s spending circa 2019-2022 was unsustainable, but now they’re pivoting too far in the other direction. At some point, Disney needs to stop shifting strategies so wildly. Really, Disney should have made fewer shows for Disney+ at launch and the shows they did make at that time needed to be made at more reasonable budgets. And they should adopt that strategy now. Winner: Daredevil: Born Again Daredevil, the Marvel Comics character, is on my personal Mount Rushmore of favorite superheroes, so it pains me to give him the win/loss today, but this show deserves it. I’ll repeat my hot take from last spring: “Based on his popularity, Daredevil should be in movies, and probably ones that cost a lot less than the MCU’s usual price tag. Disney/Bob Iger/Ike Perlmutter (who, based on reporting, made the decision) made a huge mistake selling TV shows to Netflix in the 2010s, thus limiting this character to the small screen. Daredevil could have anchored Marvel’s post-Infinity War plans, and if he did, the MCU would probably be in a better place than it is now.” HBO Max We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… What four streamers had the most misses... HBO’s strong start to 2026… The caveat to Peacock’s turnaround this year... Paramount+’s key man problem… What country isn’t delivering hits for Netflix or Hulu... The cavalcade of stars on a streamer where no one is watching their shows... Across nearly 5,000 words of analysis… And a lot more... ...please subscribe! We can only keep doing this great work with your support. If you’d like to read more about why you should subscribe, please read this article about the Streaming Ratings Report, why it matters, why you need it, and why we cover streaming ratings best.
Newcastle battle past Millwall to reach League Cup fourth round
Newcastle battled into the League Cup fourth round as Joe Willock's late goal sealed a bruising 1-0 win against Millwall on Tuesday.But Newcastle survived to keep alive their bid to win the League Cup for a second time in three years.
Unlocking Forest Diversity from Above: Fieldwork at Smithsonian’s BiodiversiTREE
Laying groundwork for using airborne remote sensing to better understand the characteristics of forest species diversity.
Richarlison Accepts Vasco Offer but Tottenham Loan Limit Blocks Move
Richarlison has reportedly agreed to join Campeonato Brasileiro Série A side Vasco da Gama, but the move can’t proceed because Tottenham Hotspur have already reached their limit for international loans.
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
Cowboys trade rumor could lead to blockbuster in-season deal
The Dallas Cowboys could be in for an eventful start to the 2026-27 NFL season.
I found 5 ways to use my Android camera that have nothing to do with photos
I unlocked completely different uses for the camera
Hunter Biden launching a laptop-themed cryptocurrency
Hunter Biden's $Laptop meme coin launches on Base blockchain, with 20% of tokens going to those who lost money on Trump's $TRUMP crypto coin.
What Formula One Engineering Can Teach Us About AI Infrastructure
Michael Fuller, Executive Chairman of Conflux Technology, examines why thermal performance alone is no longer enough in modern data centers, and how balancing heat transfer with hydraulic efficiency can unlock significant operational gains. The AI era is forcing data center operators to rethink some long-held assumptions about infrastructure design. As processor power densities continue to […]
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Dan Stevens and Gabriel Luna are the new killers on the block in season 2 of ‘Dexter: Resurrection’ (exclusive)
See the exclusive first look at Dan Stevens and Gabriel Luna as the newest serial killers on ‘Dexter: Resurrection,’ as well as the shocking return of Krysten Ritter.
Dan Stevens and Gabriel Luna are the new killers on the block in season 2 of “Dexter: Resurrection” (exclusive)
Showrunner Clyde Phillips previews the emergence of the two new serial killers, as well as the shocking return of Krysten Ritter.
Champions League Matchday One: Four things to watch
The Champions League is back this week as Europe's elite begin their pursuit of club football's biggest prize.Matchday one brings blockbuster reunions, unwanted records and plenty of questions for som...
Getting Brown proved to be the move that unlocked …
Getting Brown proved to be the move that unlocked …
Six decades of politics (but little government)
The first aired episode of “Star Trek,” entitled “The Man Trap,” premiered on September 8, 1966 — 60 years ago today. I’m actually editing a political science fiction issue of The Forum right now, and it’s prompted to me think a lot about the ways that Trek deals with politics and government and what it’s offered us as commentary. The @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe The original TV series ran from 1966 to 1969. It had a loyal but modest following, but the audience grew substantially with the series in syndication for years after that. The franchise developed its first motion picture in 1979, followed by five sequels, and then a whole other series of films built around the “Next Generation” series that first aired in 1987. In recent decades, several more TV series have built up around it, including the current “Strange New Worlds,” now in its fourth season. Throughout the past six decades, the franchise has offered us a good many insights into US politics and international relations, although often disguised as science fiction yarns. The original series was largely a Cold War fable, with the United Federation of Planets (a stand-in for the US) perpetually at odds with the Klingon Empire (a stand-in for the USSR). The “Let That Be Your Last Battlefield” episode (1969) posited a planet divided into two races, largely indistinguishable to outsiders, but nonetheless constituting a brutal racial hierarchy. “Patterns of Force” (1968) showed a struggling planet where the leader had attempted to construct a benevolent dictatorship — literally Nazism without bigotry — and found that authoritarianism could not exist apart from hierarchy and oppression. (Relatedly, I’d put “Star Trek VI: The Undiscovered Country,” high on a list of dad films about the end of the Cold War, near “The Hunt for Red October.”) Get 20% off for 1 year Indeed, the original series itself was something of a political statement, with a multi-racial crew running the Enterprise, a diverse and largely peaceful Federation mostly free from want and oppression, and protected by Starfleet, an armed force whose scientific mission was at least as important as its military one. Famously, when Nichelle Nichols wanted to walk away from the role of Uhura on the original series, none other than Martin Luther King, Jr. met with her and urged her to remain on the show, discussing the importance of viewers seeing an intelligent Black woman as part of the command team three centuries hence. Later series in the Trek franchise offered a good deal of political commentary on their own, but probably none as explicitly and incisively as “Deep Space Nine,” which ran from 1993 to 1999. The episodes surrounding the Dominion War, especially the “In The Pale Moonlight” (1998), showed the compromises, sacrifices, and moral rot associated with winning even a just war — probably better than any series would until “Andor” (2022-25). In “Far Beyond The Stars” (1998), Captain Benjamin Sisko is somehow transplanted to the role of a science fiction writer in 1950s New York. The writer is frequently sidelined and his ideas stolen because publishers don’t want to credit a Black writer. Several series have depicted the secretive Section 31 — an unacknowledged black ops security force operating within Starfleet. These episodes often end up using Section 31 as a foil to show the dangers of a lawless group within a lawful society, even (especially) when that group posits itself as essential for everyone else’s freedom to continue. The current “Strange New Worlds” has played with a few political themes. I found the first two seasons of this show among the best that the Trek franchise has produced in decades, but this season and the last have really been struggling for ideas. Yet one interesting thread is the idea that the diplomatic and enlightened leadership style of Captain Christopher Pike will not work in all situations. “A Quality of Mercy” (2022), which I wrote about here, puts Pike in the middle of a battle with a Romulan vessel in an alternate timeline, and finds that Pike’s conciliatory style would actually make a lengthy and deadly war more likely, while a quick and more violent approach might have prevented the war. This season’s opener, “Valles Marineris,” shows a pre-lightspeed civilization locked in a war to the death with a neighboring planet. The idea of an alliance or a federation hasn’t even occurred to them — their ship’s commander is curious but doesn’t see it as an option. For a franchise as political as “Star Trek,” one thing we almost never see is the government. We get occasional glimpses of Starfleet’s council — mostly uniformed people at a rectangular table — but almost no sense of how the Federation is governed. Are there elections? Who is in the legislature? How much power does the president have? What kind of factional divisions do they wrestle with and how? The shows and films are pretty silent on this. We’ve seen a few military tribunals within Starfleet, but little about how civilians deal with crime and injustice. With recent years seeing some of the franchise’s more interesting plot lines and casts, it seems clear that Star Trek is still full of energy and ideas. Given the erosion of American democracy and the reshuffling of the international order, there’s no shortage of material for future shows to comment on. I’m not sure we should toast to 60 more years, but cheers to a show that continues to teach us about ourselves. Share
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