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How to watch Seahawks’ preseason game vs. Cowboys
The Seahawks unofficially kick off their championship-defense season with their preseason opener against the Cowboys. Here's how to watch.
California lawmakers must reject bills that would raise healthcare premiums
“Healthcare needs to be more affordable. But the message isn’t resonating among legislators in Sacramento.”
Lahn talks agriculture, water quality at Edgewood forum
EDGEWOOD, Iowa — On Wednesday, Republican gubernatorial nominee Zach Lahn made his campaign pitch to voters in Edgewood, where he addressed topics such as Iowa’s water quality and cancer crises,
SJC delays ruling on Boston’s White Stadium lawsuit, putting $325M plan at risk: ‘Political disaster’
Boston’s $325 million rebuild of White Stadium for a pro soccer team was dealt another blow this week, when the Supreme Judicial Court opted to take more time to consider an appeal from a community group seeking to kill the project.
Downtown Seattle hosts demonic supernatural casino show this month
Head to downtown Seattle this month, if you dare, to wager more than money at "ALL IN," an interactive theater-ish experience from Curious Levity.
Mike Vrabel gives update on Christian Gonzalez’s health after Patriots preseason absence
What Mike Vrabel said about the health of Patriots cornerback Christian Gonzalez on Friday morning.
IV therapy and wellness service business celebrates grand opening
“We want to provide the best care possible," said its chief operating officer.
Mental health expert discusses whether telehealth is appropriate for severe disorders
Jonathan Alpert, a New York psychotherapist, said virtual care can work very well, but that "there comes a point where a screen may not be enough."
IV therapy and wellness business opens
Valley Vital Care of Charleston celebrated its grand opening with a ribbon-cutting ceremony on Thursday.
“The End of Oak Street” first reviews: Anne Hathaway’s “Jurassic Park” riff hailed as ‘dumb fun done well’
While some critics flamed the sci-fi flick’s obvious Spielberg homage, others heralded it as “what the big studios should be doing right now.”
FDA approves pivotal trial for FastWave Medical's peripheral IVL system
The SPARC trial will enroll up to 125 patients with peripheral artery disease.
FDA clears next-gen peripheral thrombectomy device
The newly cleared pVasc NET includes a dual-layer filter not available on the company's previous devices.
CRISPR roadblocks: Scientists identify genes blocking gene therapy success
Like a delivery driver navigating crowded city streets, a gene-therapy-toting lipid nanoparticle faces a gauntlet of potential detours on its journey toward a cell's nucleus. First, there's entering the ...
Gorge Amphitheatre founders plan new music venues
The project, dubbed The Hilltop, will feature a 1,000 to 1,200-seat indoor theater and a 2,000-seat outdoor venue on a property adjacent to the Gorge Amphitheatre.
Maine shifts focus to mental health as PFAS crisis deepens
State policymakers will use emotional aid and peer mentoring to address the stress of impacted farmers.
Florida’s appointed attorney general rakes in more campaign cash
The money into the attorney general’s campaign account included $2,670 from the state’s public financing program.
Business picking up steam at Fall River's new Mill & Roast Coffee Co.
Mill & Roast Coffee is quietly creating a buzz in Fall River, a new spot with handcrafted coffees and tasty treats.
Bozeman hosts ribbon cutting on new million dollar turf field
Bay District Schools will unveil a new AstroTurf field during a ribbon cutting ceremony at Deane Bozeman this Friday.
Downtown Portland is gaining an unsavory reputation. Businesses say safety concerns must be addressed.
People nodding off in doorways. Aggressive panhandling along Congress Street. Needles and other waste on sidewalks. What more can be done?
The Herald's weekly entertainment picks
Looking to be entertained from Thursday, Aug. 13, through Wednesday, Aug. 19? Check out the Skagit Valley Herald’s weekly recommendations.
Pro-crypto PAC fabricates Miami Herald headlines to attack Florida Democrat
Protect Progress has disclosed spending more than $1 million to oppose Oliver Gilbert’s candidacy in Florida’s 24th Congressional District.
Small Business Spotlight: Specialty dental practice takes root on Market St.
WHAT MADE YOU WANT TO OPEN BLUE HERON ROOT CANAL SPECIALISTS? OWNER SARAH ERMOSHKIN: “I’ve always been an entrepreneur at heart. When I was 23 years old, I owned a cafe in Seattle, where I even fought to oppose oppressive sales taxes on espresso drinks. After selling that business, I got married and started a family. Once my children were in school, I attended dental school through the Navy Health Professions Scholarship Program (HPSP), which covered my tuition and provided a stipend. From the beginning, my goal was to eventually own my own practice after completing my military service. The work I do is incredibly rewarding and being able to create an environment that puts patients first while helping employees grow professionally makes every day as a business owner meaningful.” WHAT DOES YOUR BUSINESS PROVIDE? ERMOSHKIN: “Endodontists are often called ‘pain doctors’ because our primary mission is to relieve pain and save natural teeth. We specialize in root canal therapy, retreatment of nonhealing root canals, treatment of root resorption, apicoectomies – microsurgical root-end procedures – and vital pulp therapy for children. Our goal is to preserve teeth that might otherwise need to be extracted and replaced with implants. Saving a patient’s natural tooth is almost always the best long-term solution for their oral health.” HOW DOES YOUR MILITARY TRAINING HELP YOUR BUSINESS? ERMOSHKIN: “My military service taught me how to lead, collaborate and make decisions under pressure. I worked closely with senior leadership while treating a large patient population and collaborating with specialists across multiple disciplines. During the COVID-19 pandemic, (I) served a dual role as Navy dentist and as the public affairs officer for Naval Health Clinic Annapolis, where I helped develop medical and dental communications for the midshipmen and support staff, while coordinating with the broader Navy Capital Region. We worked closely with other military treatment facilities to share best practices and deliver consistent public health messaging. Those leadership experiences continue to shape how I lead my team and serve our patients today.” WHAT CHALLENGES ARE YOU FACING RIGHT NOW IN YOUR BUSINESS? ERMOSHKIN: “One of our biggest challenges is overcoming the misinformation surrounding root canal treatment. Root canals are safe, effective and often the best way to relieve pain while preserving a natural tooth. Unfortunately, many people choose extraction because they believe it’s less expensive or because they’ve seen misleading information online. What they may not realize is that losing a tooth can lead to shifting teeth, changes in the way they bite and chew and significantly higher costs to restore their smile later.”
Protalix BioTherapeutics Reports Second Quarter 2026 Financial and Business Results
Company to host conference call and webcast today at 8:00 a.m. EDT Revenues from selling goods increased to $19.8 million in the second quarter of 2026, up...
Australia announce playing XI for first Test vs Bangladesh; Hazlewood returns, Weatherald set for debut
Australia's Test squad for the upcoming series against Bangladesh has been confirmed by captain Pat Cummins. With Jake Weatherald set to debut as an opening batsman, seasoned bowlers Josh Hazlewood and Mitchell Starc rejoin the pace lineup. Nathan Lyon is also back, prepared to lead the spin department. The opening match kicks off on August 13 in Darwin.
US bars federal funding of gender-affirming care for low-income minors
WASHINGTON, Aug 11 (Reuters) - The Trump administration finalized a rule on Tuesday barring two major federal health programs from funding puberty blockers, hormone therapy and surgeries to treat gend...
7 page-turning nonfiction history books
This mix of newer and older titles are page-turners in the best sense; you'll learn something new on each page and want to keep reading!
YouTube sensation Ms. Rachel announces debut album with Mr. Aron, 'I'm So Happy'
YouTube sensation Ms. Rachel and her husband, Aron Accurso, are releasing their debut album, “I'm So Happy,” on Sept. 25. Known for her educational YouTube channel, Ms. Rachel, whose real
Intensity Therapeutics Reports Second Quarter 2026 Financial Results and Provides Business Update
/PRNewswire/ -- Intensity Therapeutics, Inc. ("Intensity" or "the Company") (Nasdaq: INTS), a late-stage clinical biotechnology company focused on the...
Brenda Lucas: Community news for Tuesday, Aug. 11
Click for community news in the Huntington, West Virginia, and Tri-State area.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
Twice’s Jeongyeon leaves JYP after 11 years, joins Varo Entertainment
Jeongyeon of Twice on Monday announced her departure from JYP Entertainment after 11 years, but will continue her activities with the group. In a handwritten no
Who really needs testosterone?
The military plans to start screening service members for low testosterone, and social media is overflowing with claims about testosterone therapy. But who actually needs it?
Michigan’s phonics push could squeeze out knowledge
Keith Kindred writes that Michigan needs the science of reading - but kids need more than the ability to decode the words.
ABL Ascend Advanced Therapies Names Suman Subramanian as Chief Business Officer
ROCKVILLE, MD / ACCESS Newswire / August 10, 2026 /ABL Inc and Ascend Advanced Therapies today announced the appointment of Suman Subramanian as Chief Business Officer (CBO), further strengthening the Company's commercial leadership and its commitment ...
How to find out who’s behind the political text messages you’re getting
From political advertising to polling, here are a few tips.
Brewer Science strengthens US semiconductor supply chain with Heraeus Epurio acquisition
Brewer Science expands its US semiconductor materials business by acquiring Heraeus Epurio’s ultrapure chemicals operations.
Korea’s market volatility becomes TV entertainment
Amid the highs and lows of South Korea’s stock market, a new television trend is taking shape — entertainment programs built around the emotional rollercoaster
Business Briefcase: Open-air downtown farm market underway
SHENANDOAH — Schuylkill County’s longest running seasonal outdoor downtown farm market is continuing its run from 8 a.m. to noon Tuesdays and Fridays through November along the east side of the first block of South Main Street. Launched in …
JSerra looks to repeat as Southern Section flag football champions
The Lions went undefeated in 2025, but former champion Orange Lutheran and Sierra Canyon, with talented transfers, will be among formidable challengers.
Pols & Politics: Former Gov. Charlie Baker to headline Dem DA candidate’s fundraiser, snubs GOP hopeful
Charlie Baker is hosting a fundraiser for a Democratic DA candidate while snubbing the GOP challenger. Plus: Spilka responds to criticism of a veteran campaign sign and another Healey endorsement.
Politics: Iowa AG talks victim support, election during Dubuque visit
During a visit to Dubuque on Thursday, Iowa Attorney General Brenna Bird spoke with the Telegraph Herald about her outlook on the 2026 election and her work aiding crime victims.
2 Democrats competing in congressional primary to represent SW Wisconsin
Two Democratic candidates seek their party’s nomination in Tuesday’s primary election to represent southwest Wisconsin in Washington next year.
University of Michigan plans to shield 2027 freshman letter grades from transcripts in new mental health plan
The University of Michigan's new pass-fail grading policy for 2027 freshmen aims to curb the mental health crisis, but a psychotherapist warns it may backfire.
25 Years Ago, This Critically Acclaimed RPG Heralded the End of an Era
Though a new dawn may be breaking again
West Virginia Aviation Hall of Fame welcomes Huntington native
A Huntington native was recently inducted into the West Virginia Aviation Hall of Fame for his personal and professional accomplishments over the last 50 years.
Brenda Lucas: Community news for Saturday, Aug. 8
Click for community news in the Huntington, West Virginia, and Tri-State area.
Physiotherapist lifts martial arts world title
Becky Sheppard says the win feels "surreal" as she now awaits ankle surgery for an ongoing injury.
Deputies shoot armed person ‘experiencing a mental health episode,’ Riverside County Sheriff’s Office says
Deputies shot an armed person “experiencing a mental health episode” in Moreno Valley Friday, according to the Riverside County Sheriff’s Office. Sheriff’s deputies and a clinical therapist from th…
Downtown Sarasota is losing a beloved business after 27 years
Downtown Sarasota is losing a beloved Main Street business after 27 years, bringing an emotional end to a longtime local favorite
House Democrats Demand Answers From Trump’s VA on Vets Struggling to Access Mental Healthcare
A letter from Democratic lawmakers to VA Secretary Doug Collins cites a recent ProPublica investigation that found hundreds of therapists have left the agency and vets often aren’t getting the help they need.
Everyone's talking about hormone therapy for menopause. Should I be on it?
For years doctors advised women against hormone therapy for women in the menopausal transition. Now everyone's talking about how great it is. Is it really a wonder drug that women should all be on?
Congo Ebola health workers protest unpaid wages, disrupting response as deaths top 1,800
They are the latest group to walk off their jobs since protests over pay issues began weeks ago.
Vanderbilt Health physical therapist bound for Nationals after winning four medals at Tennessee Senior Olympics
Vanderbilt Health physical therapist Grant Schlisner, PT, DPT, Cert. MDT, won four medals in the recent Tennessee Senior Olympics, which qualifies him to compete in the national Senior Olympics, set for July 2027 in Tulsa, Oklahoma. Senior Olympians are athletes 50 years or older who compete in regional events for an opportunity to move to state events, and eventually to the Nationals. Schlisner’s medals were in the javelin, discus and softball throw (gold) and shot put (bronze). Schlisner, who is based at Vanderbilt Health One Hundred Oaks, grew up in the Chattanooga area in a family that valued physical fitness and playing sports, and he says, with considerable understatement, “The whole family is quite athletic.” Grant Schlisner (R) with brother Bret and sister Sue, all of whom won medals in the Tennessee State Senior Olympics. (photo courtesy Grant Schlisner) His brother Bret also competed in the Senior Olympics. So did his sister Sue. (His other sister Tammy did not compete, but, Schlisner said, “We’re still going to work on her.”) And their father, who now lives in South Dakota, competed in that state’s Senior Olympics in the category for athletes aged 84 to 89. Schlisner was a high school athlete in several sports, including stints as a baseball pitcher and a football quarterback. Since he was already playing positions in other sports in which he was throwing things, he was also recruited to the school’s track and field team, which is where he gained experience in the events that were his ticket to the 2027 Nationals. The medals are a reward for the hard work of training and preparation, but Schlisner said the real reward is the fitness that the medals represent. Schlisner competes in one of his medal-winning events, the shot put. (photo courtesy Grant Schlisner) “[Preparing for competition] got me working out to train for these events. I added more extensive weight training to promote injury prevention and building flexibility and strength have made me feel better overall.” He also said that, in addition to the physical rewards, he enjoys the camaraderie of the other athletes and a feeling of accomplishment. “It’s great to be able to have a goal,” he said. “If you aim low, you’ll hit it. This is aiming high. I want to bring home a medal in the Nationals.” His physical therapy patients, especially those who may be discouraged or need a little extra motivation, also benefit from his example. “I can connect with patients and say, ‘I’m 57 with previous injuries, and I’ve been doing these events, and you can get back to your ‘sport’ as well, whether that is chasing grandkids or participating in a competitive activity,’” he said. And being around the other Senior Olympians, especially in the older age groups, is motivating for him, as well. “One competitor was 90 years old,” he said. “She’s not just sitting around. That was super motivating and cool to see. I don’t want to be a lump on the couch at 90.”
As AI 'therapists' dish out advice, California lawmakers try to set some limits
A new bill would stop companies from marketing chatbots as therapy and force stricter oversight of AI in mental health care — as a labor union wages a parallel fight against Kaiser Permanente.
700-acre motor sports park in Powhatan gets thumbs-down from planning commission
“It’s not going to stay a 700-acre hunting property forever,” said Throttle Therapy owner Scott McAdoo. “We’re just trying to keep Powhatan rural by supporting outdoor recreation.”
The Herald's weekly entertainment picks
Looking to be entertained from Thursday, Aug. 6, through Wednesday, Aug. 12? Check out the Skagit Valley Herald’s weekly recommendations.
Intellia Therapeutics Announces Second Quarter 2026 Financial Results and Business Updates
The Investor Relations website contains information about Intellia Therapeutics's business for stockholders, potential investors, and financial analysts.
Clopidogrel monotherapy bests aspirin when patients with diabetes undergo PCI
After an initial period of DAPT, what's the best next step? A new analysis reviewed data from the SMART-CHOICE 3 clinical trial.
DHS: Mass. lawmakers putting ‘politics above public safety’ with signing of Protect Act
DHS is slamming Massachusetts lawmakers after Gov. Healey signed the Protect Act into law, which limits ICE’s capabilities, saying Bay State politicians are “putting politics above public safety.”
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Volastra Therapeutics Subleases 18K SF at Alexandria Center for Life Science
Volastra Therapeutics signed an 18,120-square-foot lease in the Alexandria Center for Life Science at 430 East 29th Street.
Essentia Health, Park Avenue Therapies announce collaboration in Cloquet
Essentia Health is excited to announce it will purchase the therapy practice of Park Avenue Therapies, a longtime community pillar in Cloquet.
SM Entertainment unveils second-half lineup
SM Entertainment unveiled its second-half artist lineup Wednesday, confirming new releases by Minho of Shinee and boy group WayV, along with a single from a new
Report: Aaron Donald exploring media space, developing docuseries
Aaron Donald has signed with a management team to "grow his business, brand partnerships and overall profile" in media and entertainment.
Wickliffe optometrist celebrates 50 years in business
Dr. Sid Savitt has now been in business in Wickliffe for 50 years as an optometrist at Savitt’s Optometry. Located at 29610 Euclid Ave., Savitt said his practice has been a “wonderful ride” since he started it in 1976. As his mom and dad…
‘Implementing terror’: Miami business owners feeling pain of losing TPS workers
. “People are paying for a service, and you have to render that service to the highest quality and standard.”
CVS Health enhances its direct-to-consumer weight management offerings to improve access, affordability, care and support for GLP-1 medications
CVS Health® today announced a revamp of its weight management program, making it easier for eligible adults to access clinical care, navigate medication costs and get ongoing support for GLP-1 therapy.
AI generates personalized radiopharmaceutical therapy doses in under 23 seconds
The model has the potential to improve upon the one-size-fits-all dosing approach used for most RPT prostate cancer treatments.
The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
Maine to award $30 million through federal rural health fund
The Maine Department of Health and Human Services said it has identified 11 rural hospitals that could participate.
Englewood Festival entertainment announced
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Garfinkel steps away as Dolphins president. Sillman takes on larger role. Details
Dolphins announce changes in leadership. Here’s the team’s succession plan and more.
Commissioners vote to keep health insurance spending the same as 2026
The county will likely need to change health insurance plans to avoid an anticipated 20% increase for next year under its current plan.
Millionaire tax is good for Maine businesses, good for Maine
By raising revenue to help people meet basic needs, we give them a better chance of remaining in their jobs and communities.
Ocular Therapeutix Reports Second Quarter Revenue, Provides Business Highlights
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Healey announces first steps to lower health care costs, investment in primary care
Massachusetts is setting out to lower health care costs with steps like investing more state resources in primary care, supporting nursing recruitment, standardize out-of-network service rates and more, Gov. Maura Healey announced Monday…
A common sugar may help cancer cells break free and spread
Chemotherapy-surviving ovarian cancer cells may release fructose to help neighboring tumor cells loosen, escape, and spread. The discovery suggests that sugary diets and cholesterol-lowering drugs could influence cancer progression, though the effects have not yet been confirmed in patients.
August 6 Vallejo/Vacaville Arts-Entertainment Source: Activities
The Benicia Peddlers Fair is all day Saturday in downtown Benicia.
‘Hair: The American Tribal Love-Rock Musical’
When “Hair” premiered on Broadway in 1968, after two off-Broadway runs and extensive revisions, it broke new ground.
Beyond crayons: Art therapy tackles youth mental health crisis here
Program leaders report seeing students develop a sense of belonging, confidence and resilience.
A simple supplement could help the immune system fight cancer and viruses
Low arginine levels may allow cancer cells and viruses to slip past the immune system by reducing production of a crucial cellular warning protein. In mice, arginine-rich diets led to fewer colon tumors and milder viral infections, suggesting a simple supplement could have powerful therapeutic potential.
Will Broward hospitals merge? Here’s what the CEO said about the future of care
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Unheralded Cowboys Rookie Turns Heads at Training Camp
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Business Briefcase: Nominations are open for 2026 chamber awards gala
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Pols & Politics: Gov’s race shifts focus towards growing GOP stronghold on south coast
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Opinion | Therapy should be a safe place for everyone, including Zionists
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Politics: RNC, Iowa GOP file lawsuit to enforce signature verification on absentee ballots
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Voter guide: Everything South Florida needs to know about voting in August
You don’t have to be a Democrat or Republican to participate
How scientists are trying to repair the body from within: Regenerative medicine and anti-aging
At Scripps Research and its drug discovery arm, the Calibr-Skaggs Institute for Innovative Medicines, scientists are developing regenerative medicine therapies designed to help the body repair itself from within. Unlike traditional medicines that primarily manage symptoms or slow disease progression, regenerative medicine aims to restore damaged tissues and rebuild function lost to aging and disease. Researchers are advancing programs focused on the heart, lungs, digestive tract and eyes, including investigational therapies for heart failure, idiopathic pulmonary fibrosis, inflammatory bowel disease, age-related macular degeneration and other chronic conditions that become more common as we age. Learn how scientists are activating the body’s natural repair mechanisms to explore a future where medicine may not only treat disease, but help reverse its damage.
Does public health *need* MAHA?
Last week, our friend Dr. Craig Spencer sparked an ongoing volatile discussion with his Atlantic article “Public Health Needs MAHA.” Some have come out in strong dissent, others are cheering, and others are simply lamenting that we find ourselves in such a divided world to begin with. We will dare to dip our toes in these controversial waters, too. Does public health need MAHA? We think in some ways yes, and in other ways, no. MAHA leaders versus the everyday MAHA supporter The vitriol in this debate mostly comes from one collapsed distinction: the leadership of MAHA is not necessarily the same as the people who support it. Say “MAHA” and most people picture RFK Jr. Fair enough, as he coined the term and holds most of the power. And, yes, some MAHA followers treat Kennedy as something close to a saint. But talk to the grassroots, and it’s not a monolith. They’re Republicans, Democrats, and Independents. People who distrust vaccines and vaccine supporters. It’s a wide, eclectic coalition. The data backs this too: 4 in 10 Americans support the movement—that’s a lot of people! But according to polls, vaccines and medical choice (the issues most tied to Kennedy personally) are cited by only 4% as their reason for supporting the movement. For many, the motivations are much broader. Many MAHA supporters are signing up for the idea that “something needs to change” with health in this country. They’re asking good-faith questions about corporate influence on our health systems, health care costs, nutrition, chemicals, and clean air and water. These are all questions that plenty of public health professionals recognize as legitimate and also care about very deeply. Blurring the lines between the leadership and grassroots does real damage in two important ways: It hands the 4 in 10 exactly the narrative already fed—that the health ecosystem doesn’t listen, doesn’t care, and paints every critic with the same brush. It gives the actual bad actor more power. RFK Jr. has done irreparable damage and can’t be trusted. What the MAHA movement gets right A healthy population is something the public health field was literally built on, and many of these topics are things we have dedicated our lives to. Yet the MAHA movement has captivated nearly half the country in a way the public health establishment has failed to achieve. So that means MAHA is doing something right. Some of it may be timing (after a Covid-19 pandemic and deep frustration and mistrust with institutions). The movement also does three other things really well: 1. It gives a new, louder voice to system failures. While MAHA is not a monolith, one theme stays consistent across their stories: the system failed them. For some, it was the system that flooded their communities with opioids and then walked away. For others, it was the system that let their business collapse during Covid with no safety net in sight. For others still, it was the system that failed to help them manage a complex chronic illness, bouncing them from physician to physician without any real answers. And in many ways, our health ecosystems are failing Americans. Why are medical bills so incomprehensible? Why do some kids get a healthy school lunch and others don’t? Why do an epidemiologist and a MD/PhD student have to start newsletters in the middle of the biggest public health emergency in a century, just so people can get straight information? Because the systems failed. This deep-seated frustration driving many Americans to search for solutions elsewhere needs to be recognized. 2. MAHA has brilliant comms central to their efforts. MAHA figured out something most health institutions still have not: the information landscape changed. It’s participatory now, not top-down; influence runs through many nodes in a community, not one institution; and storytelling and telling audiences “what you really think” moves people more than data dumps do. MAHA goes where audiences are listening, using podcasts, social media, and memes in ways most health institutions would scoff at—but it works. 3. They are very good at organizing. A MAHA meeting feels like a rally: energy, speakers, music, and most importantly, an action for everyone. Someone’s writing the next policy brief, someone’s seeding a narrative, someone knows the next legislative deadline, someone’s sending the text messages for a campaign. None of this is new (ask the civil rights movement), but MAHA knows it works and has capitalized on it. What MAHA gets wrong This list could be much longer, and this newsletter has spent a lot of time covering it, but here are a few things: Poor use of scientific evidence. This is the fundamental problem with many MAHA policies: the hype outpaces the science, and experts are often villainized for pointing this out. MAHA leadership has traded real solutions for cheap wins. For example, instead of taking on the powerful food industry and passing real reforms, it has celebrated french fries made of beef tallow and taken out artificial dyes from still very sugary children’s cereal. These changes won’t move the needle on America’s diet. MAHA leadership has tried to dismantle vaccine access in the U.S. While many MAHA supporters emphasize other issues, the effort to change vaccine policy has become MAHA’s signature effort. This is not surprising given RFK Jr.’s extensive track record campaigning against vaccines. It has rallied behind the wrong leader. RFK Jr. has a decades-long track record of villifying doctors, scientists, and public health workers, well before he became HHS secretary. He is known for his decades-long work sowing distrust in vaccines as well as life-saving treatments like antiretroviral therapy for HIV. This is not a serious person who can move the needle on health in the U.S, and he has already done serious damage. Public health needs more than defense Defending the evidence is absolutely necessary so health in the U.S. doesn’t move further backward. The public health establishment is very good at defense. The problem is this defense often sounds like defending the status quo, which has failed many people. Public health needs to offer an alternative to RFK Jr.’s MAHA—one that is rooted in evidence, truly listens to and addresses people’s frustrations, and has innovative solutions and the courage to change the systems. How do we get there? Find common ground. Do you know what most people care most about? The abysmal cost of healthcare. Start there. Fight for the human loudly. Too often, communications and engagement center on science with a capital S, funding mechanisms, or the CDC/FDA/NIH. Not the person. So the public doesn’t see themselves in it. Instead, they see people fighting for the very powerful systems that they feel negatively impact their health and well-being. Let the public feel and hear that you see their frustrations, you get it, and you’re fighting for them within the system. Recognize when pro-science messages are alienating people. Facts absolutely matter, but angrily venting only alienates people further. Our friend Elisabeth Marnik recently wrote a New York Times article about her experience growing up unvaccinated and how listening and empathetic conversation are the only ways to reach people that really work (a position backed by communication science). Her comments section was full of hateful comments from pro-vaccine individuals attacking her for daring to suggest we approach vaccine-hesitant individuals with empathy. It is possible to both stand firm behind scientific evidence and empathize with people who don’t trust it. Lean into politics smartly. Often, public health has shied away from politics: Don’t touch it, lest you get burned. But this fails to recognize that the third rail is what fuels the train: who is elected determines our budgets, our priorities, and our authority. Being political means being very savvy in strategy on both sides of the aisle, knowing your audience, and recognizing that political capital is as scarce as financial resources and needs to be allocated accordingly. Bottom line So does public health need MAHA? That’s not really the right question. Public health has a responsibility not to dismiss 40% of the country who feel heard by this movement and are frustrated that the system has failed them. And it has a responsibility to stick to the evidence and recognize MAHA leadership for what it is: a danger to our nation’s health. Both can, and should, be done. Love, YLE and KP A big thanks to Craig Spencer, who had the courage to put his neck out there to start a much-needed discussion at such a critical moment—one that is determining the identity of an entire field. Kristen Panthagani, MD, PhD is completing an emergency medicine residency and research fellowship focusing on health literacy and communication. In her free time, she writes the newsletters You Can Know Things debunking health myths and rumors and The Public Health Roundup. Views expressed belong to KP, not her employer. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. The YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Mercer students provide behavioral healthcare to farmworkers
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Harvard Business School announces 2026-2027 Blavatnik Fellows
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